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409 results on '"Casabonne, Delphine"'

1. Lifetime exposure to brominated trihalomethanes in drinking water and swimming pool attendance are associated with chronic lymphocytic leukemia: a Multicase-Control Study in Spain (MCC-Spain)

Author

Donat-Vargas, Carolina, Kogevinas, Manolis, Benavente, Yolanda, Costas, Laura, Campo, Elias, Castaño-Vinyals, Gemma, Fernandez-Tardon, Guillermo, Llorca, Javier, Gómez-Acebo, Inés, Aragonés, Nuria, Pollan, Marina, Casabonne, Delphine, and Villanueva, Cristina M.

Published
2024
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2. Distinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes

Author

Berndt, Sonja I., Vijai, Joseph, Benavente, Yolanda, Camp, Nicola J., Nieters, Alexandra, Wang, Zhaoming, Smedby, Karin E., Kleinstern, Geffen, Hjalgrim, Henrik, Besson, Caroline, Skibola, Christine F., Morton, Lindsay M., Brooks-Wilson, Angela R., Teras, Lauren R., Breeze, Charles, Arias, Joshua, Adami, Hans-Olov, Albanes, Demetrius, Anderson, Kenneth C., Ansell, Stephen M., Bassig, Bryan, Becker, Nikolaus, Bhatti, Parveen, Birmann, Brenda M., Boffetta, Paolo, Bracci, Paige M., Brennan, Paul, Brown, Elizabeth E., Burdett, Laurie, Cannon-Albright, Lisa A., Chang, Ellen T., Chiu, Brian C. H., Chung, Charles C., Clavel, Jacqueline, Cocco, Pierluigi, Colditz, Graham, Conde, Lucia, Conti, David V., Cox, David G., Curtin, Karen, Casabonne, Delphine, De Vivo, Immaculata, Diepstra, Arjan, Diver, W. Ryan, Dogan, Ahmet, Edlund, Christopher K., Foretova, Lenka, Fraumeni, Jr, Joseph F., Gabbas, Attilio, Ghesquières, Hervé, Giles, Graham G., Glaser, Sally, Glenn, Martha, Glimelius, Bengt, Gu, Jian, Habermann, Thomas M., Haiman, Christopher A., Haioun, Corinne, Hofmann, Jonathan N., Holford, Theodore R., Holly, Elizabeth A., Hutchinson, Amy, Izhar, Aalin, Jackson, Rebecca D., Jarrett, Ruth F., Kaaks, Rudolph, Kane, Eleanor, Kolonel, Laurence N., Kong, Yinfei, Kraft, Peter, Kricker, Anne, Lake, Annette, Lan, Qing, Lawrence, Charles, Li, Dalin, Liebow, Mark, Link, Brian K., Magnani, Corrado, Maynadie, Marc, McKay, James, Melbye, Mads, Miligi, Lucia, Milne, Roger L., Molina, Thierry J., Monnereau, Alain, Montalvan, Rebecca, North, Kari E., Novak, Anne J., Onel, Kenan, Purdue, Mark P., Rand, Kristin A., Riboli, Elio, Riby, Jacques, Roman, Eve, Salles, Gilles, Sborov, Douglas W., Severson, Richard K., Shanafelt, Tait D., Smith, Martyn T., Smith, Alexandra, Song, Kevin W., Song, Lei, Southey, Melissa C., Spinelli, John J., Staines, Anthony, Stephens, Deborah, Sutherland, Heather J., Tkachuk, Kaitlyn, Thompson, Carrie A., Tilly, Hervé, Tinker, Lesley F., Travis, Ruth C., Turner, Jenny, Vachon, Celine M., Vajdic, Claire M., Van Den Berg, Anke, Van Den Berg, David J., Vermeulen, Roel C. H., Vineis, Paolo, Wang, Sophia S., Weiderpass, Elisabete, Weiner, George J., Weinstein, Stephanie, Doo, Nicole Wong, Ye, Yuanqing, Yeager, Meredith, Yu, Kai, Zeleniuch-Jacquotte, Anne, Zhang, Yawei, Zheng, Tongzhang, Ziv, Elad, Sampson, Joshua, Chatterjee, Nilanjan, Offit, Kenneth, Cozen, Wendy, Wu, Xifeng, Cerhan, James R., Chanock, Stephen J., Slager, Susan L., and Rothman, Nathaniel

Published
2022
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3. Correction: Distinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes

Author

Berndt, Sonja I., Vijai, Joseph, Benavente, Yolanda, Camp, Nicola J., Nieters, Alexandra, Wang, Zhaoming, Smedby, Karin E., Kleinstern, Geffen, Hjalgrim, Henrik, Besson, Caroline, Skibola, Christine F., Morton, Lindsay M., Brooks-Wilson, Angela R., Teras, Lauren R., Breeze, Charles, Arias, Joshua, Adami, Hans-Olov, Albanes, Demetrius, Anderson, Kenneth C., Ansell, Stephen M., Bassig, Bryan, Becker, Nikolaus, Bhatti, Parveen, Birmann, Brenda M., Boffetta, Paolo, Bracci, Paige M., Brennan, Paul, Brown, Elizabeth E., Burdett, Laurie, Cannon-Albright, Lisa A., Chang, Ellen T., Chiu, Brian C. H., Chung, Charles C., Clavel, Jacqueline, Cocco, Pierluigi, Colditz, Graham, Conde, Lucia, Conti, David V., Cox, David G., Curtin, Karen, Casabonne, Delphine, De Vivo, Immaculata, Diepstra, Arjan, Diver, W. Ryan, Dogan, Ahmet, Edlund, Christopher K., Foretova, Lenka, Fraumeni, Jr, Joseph F., Gabbas, Attilio, Ghesquières, Hervé, Giles, Graham G., Glaser, Sally, Glenn, Martha, Glimelius, Bengt, Gu, Jian, Habermann, Thomas M., Haiman, Christopher A., Haioun, Corinne, Hofmann, Jonathan N., Holford, Theodore R., Holly, Elizabeth A., Hutchinson, Amy, Izhar, Aalin, Jackson, Rebecca D., Jarrett, Ruth F., Kaaks, Rudolph, Kane, Eleanor, Kolonel, Laurence N., Kong, Yinfei, Kraft, Peter, Kricker, Anne, Lake, Annette, Lan, Qing, Lawrence, Charles, Li, Dalin, Liebow, Mark, Link, Brian K., Magnani, Corrado, Maynadie, Marc, McKay, James, Melbye, Mads, Miligi, Lucia, Milne, Roger L., Molina, Thierry J., Monnereau, Alain, Montalvan, Rebecca, North, Kari E., Novak, Anne J., Onel, Kenan, Purdue, Mark P., Rand, Kristin A., Riboli, Elio, Riby, Jacques, Roman, Eve, Salles, Gilles, Sborov, Douglas W., Severson, Richard K., Shanafelt, Tait D., Smith, Martyn T., Smith, Alexandra, Song, Kevin W., Song, Lei, Southey, Melissa C., Spinelli, John J., Staines, Anthony, Stephens, Deborah, Sutherland, Heather J., Tkachuk, Kaitlyn, Thompson, Carrie A., Tilly, Hervé, Tinker, Lesley F., Travis, Ruth C., Turner, Jenny, Vachon, Celine M., Vajdic, Claire M., Van Den Berg, Anke, Van Den Berg, David J., Vermeulen, Roel C. H., Vineis, Paolo, Wang, Sophia S., Weiderpass, Elisabete, Weiner, George J., Weinstein, Stephanie, Doo, Nicole Wong, Ye, Yuanqing, Yeager, Meredith, Yu, Kai, Zeleniuch-Jacquotte, Anne, Zhang, Yawei, Zheng, Tongzhang, Ziv, Elad, Sampson, Joshua, Chatterjee, Nilanjan, Offit, Kenneth, Cozen, Wendy, Wu, Xifeng, Cerhan, James R., Chanock, Stephen J., Slager, Susan L., and Rothman, Nathaniel

Published
2023
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4. Genetic overlap between autoimmune diseases and non‐Hodgkin lymphoma subtypes

Author

Din, Lennox, Sheikh, Mohammad, Kosaraju, Nikitha, Smedby, Karin Ekstrom, Bernatsky, Sasha, Berndt, Sonja I, Skibola, Christine F, Nieters, Alexandra, Wang, Sophia, McKay, James D, Cocco, Pierluigi, Maynadié, Marc, Foretová, Lenka, Staines, Anthony, Mack, Thomas M, de Sanjosé, Silvia, Vyse, Timothy J, Padyukov, Leonid, Monnereau, Alain, Arslan, Alan A, Moore, Amy, Brooks‐Wilson, Angela R, Novak, Anne J, Glimelius, Bengt, Birmann, Brenda M, Link, Brian K, Stewart, Carolyn, Vajdic, Claire M, Haioun, Corinne, Magnani, Corrado, Conti, David V, Cox, David G, Casabonne, Delphine, Albanes, Demetrius, Kane, Eleanor, Roman, Eve, Muzi, Giacomo, Salles, Gilles, Giles, Graham G, Adami, Hans‐Olov, Ghesquières, Hervé, De Vivo, Immaculata, Clavel, Jacqueline, Cerhan, James R, Spinelli, John J, Hofmann, Jonathan, Vijai, Joseph, Curtin, Karen, Costenbader, Karen H, Onel, Kenan, Offit, Kenneth, Teras, Lauren R, Morton, Lindsay, Conde, Lucia, Miligi, Lucia, Melbye, Mads, Ennas, Maria Grazia, Liebow, Mark, Purdue, Mark P, Glenn, Martha, Southey, Melissa C, Din, Morris, Rothman, Nathaniel, Camp, Nicola J, Doo, Nicole Wong, Becker, Nikolaus, Pradhan, Nisha, Bracci, Paige M, Boffetta, Paolo, Vineis, Paolo, Brennan, Paul, Kraft, Peter, Lan, Qing, Severson, Richard K, Vermeulen, Roel CH, Milne, Roger L, Kaaks, Rudolph, Travis, Ruth C, Weinstein, Stephanie J, Chanock, Stephen J, Ansell, Stephen M, Slager, Susan L, Zheng, Tongzhang, Zhang, Yawei, Benavente, Yolanda, Taub, Zachary, Madireddy, Lohith, Gourraud, Pierre‐Antoine, Oksenberg, Jorge R, Cozen, Wendy, Hjalgrim, Henrik, and Khankhanian, Pouya

Subjects
Biological Sciences, Genetics, Lymphoma, Arthritis, Neurodegenerative, Brain Disorders, Autoimmune Disease, Cancer, Human Genome, Rare Diseases, Hematology, Aetiology, 2.1 Biological and endogenous factors, Inflammatory and immune system, Alleles, Autoimmune Diseases, Female, Genetic Predisposition to Disease, HLA Antigens, Humans, Lymphoma, Non-Hodgkin, Male, Middle Aged, Multifactorial Inheritance, Polymorphism, Single Nucleotide, Risk Factors, autoimmune disease, genome-wide association study, meta-analysis, non-Hodgkin lymphoma, Public Health and Health Services, Epidemiology
Abstract

Epidemiologic studies show an increased risk of non-Hodgkin lymphoma (NHL) in patients with autoimmune disease (AD), due to a combination of shared environmental factors and/or genetic factors, or a causative cascade: chronic inflammation/antigen-stimulation in one disease leads to another. Here we assess shared genetic risk in genome-wide-association-studies (GWAS). Secondary analysis of GWAS of NHL subtypes (chronic lymphocytic leukemia, diffuse large B-cell lymphoma, follicular lymphoma, and marginal zone lymphoma) and ADs (rheumatoid arthritis, systemic lupus erythematosus, and multiple sclerosis). Shared genetic risk was assessed by (a) description of regional genetic of overlap, (b) polygenic risk score (PRS), (c)"diseasome", (d)meta-analysis. Descriptive analysis revealed few shared genetic factors between each AD and each NHL subtype. The PRS of ADs were not increased in NHL patients (nor vice versa). In the diseasome, NHLs shared more genetic etiology with ADs than solid cancers (p = .0041). A meta-analysis (combing AD with NHL) implicated genes of apoptosis and telomere length. This GWAS-based analysis four NHL subtypes and three ADs revealed few weakly-associated shared loci, explaining little total risk. This suggests common genetic variation, as assessed by GWAS in these sample sizes, may not be the primary explanation for the link between these ADs and NHLs.

Published
2019

5. High-risk subtypes of chronic lymphocytic leukemia are detectable as early as 16 years prior to diagnosis

Author

Kolijn, P. Martijn, Hosnijeh, Fatemeh Saberi, Späth, Florentin, Hengeveld, Paul J., Agathangelidis, Andreas, Saleh, Manal, Casabonne, Delphine, Benavente, Yolanda, Jerkeman, Mats, Agudo, Antonio, Barricarte, Aurelio, Besson, Caroline, Sánchez, Maria-Jose, Chirlaque, María-Dolores, Masala, Giovanna, Sacerdote, Carlotta, Grioni, Sara, Schulze, Matthias B., Nieters, Alexandra, Engelfriet, Peter, Hultdin, Magnus, McKay, James D., Vermeulen, Roel C.H., and Langerak, Anton W.

Published
2022
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6. Validation and functional characterization of GWAS-identified variants for chronic lymphocytic leukemia: a CRuCIAL study

Author

García-Martín, Paloma, Díez, Ana Moñiz, Maldonado, José Manuel Sánchez, Serrano, Antonio José Cabrera, ter Horst, Rob, Benavente, Yolanda, Landi, Stefano, Macauda, Angelica, Clay-Gilmour, Alyssa, Hernández-Mohedo, Francisca, Niazi, Yasmeen, González-Sierra, Pedro, Espinet, Blanca, Rodríguez-Sevilla, Juan José, Maffei, Rossana, Blanco, Gonzalo, Giaccherini, Matteo, Puiggros, Anna, Cerhan, James, Marasca, Roberto, Cañadas-Garre, Marisa, López-Nevot, Miguel Ángel, Chen-Liang, Tzu, Thomsen, Hauke, Gámez, Irene, Moreno, Víctor, Marcos-Gragera, Rafael, García-Álvarez, María, Llorca, Javier, Jerez, Andrés, Berndt, Sonja, Butrym, Aleksandra, Norman, Aaron D., Casabonne, Delphine, Luppi, Mario, Slager, Susan L., Hemminki, Kari, Li, Yang, Alcoceba, Miguel, Campa, Daniele, Canzian, Federico, de Sanjosé, Silvia, Försti, Asta, Netea, Mihai G., Jurado, Manuel, and Sainz, Juan

Published
2022
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7. Adherence to the 2018 WCRF/AICR cancer prevention guidelines and chronic lymphocytic leukemia in the MCC-Spain study

Author

Solans, Marta, Romaguera, Dora, Gracia-Lavedan, Esther, Molinuevo, Amaia, Benavente, Yolanda, Saez, Marc, Marcos-Gragera, Rafael, Costas, Laura, Robles, Claudia, Alonso, Esther, de la Banda, Esmeralda, Gonzalez-Barca, Eva, Llorca, Javier, Rodriguez-Suarez, Marta Maria, Lozano-Lorca, Macarena, Aymerich, Marta, Campo, Elias, Gimeno-Vázquez, Eva, Castaño-Vinyals, Gemma, Aragonés, Nuria, Pollán, Marina, Kogevinas, Manolis, de Sanjose, Silvia, Amiano, Pilar, and Casabonne, Delphine

Published
2020
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8. Corrigendum to “Lifetime occupational and recreational physical activity and risk of lymphoma subtypes. Results from the European Epilymph case-control study” [Cancer Epidemiol. 87 (2023) 102495]

Author

Meloni, Federico, primary, Benavente, Yolanda, additional, Becker, Nikolaus, additional, Casabonne, Delphine, additional, Foretova, Lenka, additional, Maynadié, Marc, additional, Nieters, Alexandra, additional, Staines, Anthony, additional, Trobbiani, Carlotta, additional, Pilia, Ilaria, additional, Zucca, Mariagrazia, additional, and Cocco, Pierluigi, additional

Published
2024
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9. Inflammatory potential of diet and risk of lymphoma in the European Prospective Investigation into Cancer and Nutrition

Author

Solans, Marta, Benavente, Yolanda, Saez, Marc, Agudo, Antonio, Jakszyn, Paula, Naudin, Sabine, Hosnijeh, Fatemeh Saberi, Gunter, Marc, Huybrechts, Inge, Ferrari, Pietro, Besson, Caroline, Mahamat-Saleh, Yahya, Boutron-Ruault, Marie-Christine, Kühn, Tilman, Kaaks, Rudolf, Boeing, Heiner, Lasheras, Cristina, Sánchez, Maria-Jose, Amiano, Pilar, Chirlaque, María Dolores, Ardanaz, Eva, Schmidt, Julie A., Vineis, Paolo, Riboli, Elio, Trichopoulou, Antonia, Karakatsani, Anna, Valanou, Elisavet, Masala, Giovanna, Agnoli, Claudia, Tumino, Rosario, Sacerdote, Carlotta, Mattiello, Amalia, Skeie, Guri, Weiderpass, Elisabete, Jerkeman, Mats, Dias, Joana Alves, Späth, Florentin, Nilsson, Lena Maria, Dahm, Christina C., Overvad, Kim, Petersen, Kristina Elin Nielsen, Tjønneland, Anne, de Sanjose, Silvia, Vermeulen, Roel, Nieters, Alexandra, and Casabonne, Delphine

Published
2020
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10. Infection induced SARS-CoV-2 seroprevalence and heterogeneity of antibody responses in a general population cohort study in Catalonia Spain

Author

Karachaliou, Marianna, Moncunill, Gemma, Espinosa, Ana, Castaño-Vinyals, Gemma, Jiménez, Alfons, Vidal, Marta, Santano, Rebeca, Barrios, Diana, Puyol, Laura, Carreras, Anna, Mayer, Leonie, Rubio, Rocío, Cortés, Beatriz, Pleguezuelos, Vanessa, O’Callaghan-Gordo, Cristina, Fossati, Serena, Rivas, Ioar, Casabonne, Delphine, Vrijheid, Martine, Izquierdo, Luis, Aguilar, Ruth, Basagaña, Xavier, Garcia-Aymerich, Judith, de Cid, Rafael, Dobaño, Carlota, and Kogevinas, Manolis

Published
2021
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11. Sleep duration and napping in relation to colorectal and gastric cancer in the MCC-Spain study

Author

Papantoniou, Kyriaki, Castaño-Vinyals, Gemma, Espinosa, Ana, Turner, Michelle C., Martín-Sánchez, Vicente, Casabonne, Delphine, Aragonés, Nuria, Gómez-Acebo, Inés, Ardanaz, Eva, Jimenez-Moleon, Jose-Juan, Amiano, Pilar, Molina-Barceló, Ana, Alguacil, Juan, Fernández-Tardón, Guillermo, Huerta, José María, Hernández-Segura, Natalia, Perez-Gomez, Beatriz, Llorca, Javier, Vidán-Alli, Juana, Olmedo-Requena, Rocıo, Gil, Leire, Castañon-López, Carmen, Pollan, Marina, Kogevinas, Manolis, and Moreno, Victor

Published
2021
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12. Epstein Barr virus antibody reactivity and gastric cancer: A population-based case-control study

Author

Aragonés, Nuria, Fernández de Larrea, Nerea, Pastor-Barriuso, Roberto, Michel, Angelika, Romero, Beatriz, Pawlita, Michael, Mayorgas-Torralba, Sara, Martín, Vicente, Moreno, Victor, Casabonne, Delphine, Castilla, Jesús, Fernandez-Tardón, Guillermo, Dierssen-Sotos, Trinidad, Capelo, Rocío, Salas, Dolores, Salcedo-Bellido, Inmaculada, Chirlaque, María Dolores, Brenner, Nicole, Pedraza, Manuela, Bessa, Xavier, Pérez-Gómez, Beatriz, Butt, Julia, Kogevinas, Manolis, del Campo, Rosa, de Sanjosé, Silvia, Waterboer, Tim, and Pollán, Marina

Published
2019
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13. Association of polygenic risk score with the risk of chronic lymphocytic leukemia and monoclonal B-cell lymphocytosis

Author

Kleinstern, Geffen, Camp, Nicola J., Goldin, Lynn R., Vachon, Celine M., Vajdic, Claire M., de Sanjose, Silvia, Weinberg, J. Brice, Benavente, Yolanda, Casabonne, Delphine, Liebow, Mark, Nieters, Alexandra, Hjalgrim, Henrik, Melbye, Mads, Glimelius, Bengt, Adami, Hans-Olov, Boffetta, Paolo, Brennan, Paul, Maynadie, Marc, McKay, James, Cocco, Pier Luigi, Shanafelt, Tait D., Call, Timothy G., Norman, Aaron D., Hanson, Curtis, Robinson, Dennis, Chaffee, Kari G., Brooks-Wilson, Angela R., Monnereau, Alain, Clavel, Jacqueline, Glenn, Martha, Curtin, Karen, Conde, Lucia, Bracci, Paige M., Morton, Lindsay M., Cozen, Wendy, Severson, Richard K., Chanock, Stephen J., Spinelli, John J., Johnston, James B., Rothman, Nathaniel, Skibola, Christine F., Leis, Jose F., Kay, Neil E., Smedby, Karin E., Berndt, Sonja I., Cerhan, James R., Caporaso, Neil, and Slager, Susan L.

Published
2018
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14. Established and suggested exposures on CLL/SLL etiology: Results from the CLL-MCC-Spain study

Author

Benavente, Yolanda, Casabonne, Delphine, Costas, Laura, Robles, Claudia, Alonso, Esther, de la Banda, Esmeralda, Gonzalez-Barca, Eva, Marcos-Gragera, Rafael, Llorca, Javier, Tardón, Adonina, Monleon, José J., Aymerich, Marta, Campo, Elías, Gimeno-Vázquez, Eva, Castaño-Vinyals, Gemma, Aragonés, Nuria, Pollán, Marina, Kogevinas, Manolis, and de Sanjosé, Sílvia

Published
2018
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15. The seroepidemiology of human-papillomavirus in relation to non-melanoma skin cancer

Author

Casabonne, Delphine

Subjects
616.994, Medicine
Abstract

Non-melanoma skin cancer, comprising basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) is the most commonly diagnosed cancer in Caucasian populations. Established risk factors include exposure to solar ultra-violet radiation and immunosuppression, such as that experienced by organ transplant recipients (OTR). A role for cutaneous human papillomaviruses (HPV) in the aetiology of SCC has been suggested, but remains uncertain. The aims of this thesis were to examine the association between SCC and antibodies against the L 1 antigen of 38 HPV types using Luminex technology among Caucasian individuals and to investigate the seroepidemiology of cutaneous HPV types. Data came from a small prospective study of 39 cases and 80 controls (the Oxford component of the European Prospective Investigation into Cancer and Nutrition) and from case-control studies nested among high-risk cohorts of OTR from London and from Oxford (119 prevalent cases and 425 controls). Around 85% of controls were seroactive to at least one HPV type. In the prospective study, there were no statistically significant differences in the seroprevalence of antibodies against any of the HPV types examined between incident cases and controls. In the case-control studies, as expected, antibodies against HPV 16 were associated with a self-reported history of an abnormal cervical smear and antibodies against HPV 6 were associated with a self-reported history of genital warts, validating the methodology. However, no clear associations between any of the HPV types examined (including betaHPVs) and prevalent SCC were identified. Adjustment for potential confounding factors, such as self-reported history of sun exposure made no material difference to the results. Limitations of the studies are the low statistical power and the use of new serological assays. These serological data do not provide evidence in support of a role for HPV in the aetiology of cutaneous SCC.

Published
2009

17. Mediating effect of soluble B-cell activation immune markers on the association between anthropometric and lifestyle factors and lymphoma development

Author

Saberi Hosnijeh, Fatemeh, Kolijn, Pieter M., Casabonne, Delphine, Nieters, Alexandra, Solans, Marta, Naudin, Sabine, Ferrari, Pietro, Mckay, James D., Weiderpass, Elisabete, Perduca, Vittorio, Besson, Caroline, Mancini, Francesca Romana, Masala, Giovanna, Krogh, Vittorio, Ricceri, Fulvio, Huerta, José M., Petrova, Dafina, Sala, Núria, Trichopoulou, Antonia, Karakatsani, Anna, La Vecchia, Carlo, Kaaks, Rudolf, Canzian, Federico, Aune, Dagfinn, Boeing, Heiner, Schulze, Matthias B., Perez-Cornago, Aurora, Langerak, Anton W., van der Velden, Vincent H. J., and Vermeulen, Roel

Published
2020
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18. Reply to: Comment to: Helicobacter pylori seroprevalence in Spain: influence of adult and childhood sociodemographic factors

Author

Lorenzo, Irene, Fernández-de-Larrea, Nerea, Michel, Angelika, Romero, Beatriz, Lope, Virginia, Bessa, Xavier, Moreno, Victor, Martín, Vicente, Amiano, Pilar, Castilla, Jesús, Tardón, Adonina, Dierssen-Sotos, Trinidad, Peiró, Rosana, Díaz-Santos, Marian, Navarro, Carmen, Jiménez-Moleón, José J., Butt, Julia, Barricarte, Aurelio, Ruiz, Irune, Molina-de-la-Torre, Antonio J., Casabonne, Delphine, Pérez-Gómez, Beatriz, Kogevinas, Manolis, del Campo, Rosa, de Sanjosé, Silvia, Pollán, Marina, Waterboer, Tim, and Aragonés, Nuria

Published
2020
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19. Consumption of aspartame and other artificial sweeteners and risk of cancer in the Spanish multicase‐control study (MCC‐Spain)

Author

Palomar‐Cros, Anna, primary, Straif, Kurt, additional, Romaguera, Dora, additional, Aragonés, Nuria, additional, Castaño‐Vinyals, Gemma, additional, Martin, Vicente, additional, Moreno, Victor, additional, Gómez‐Acebo, Inés, additional, Guevara, Marcela, additional, Aizpurua, Amaia, additional, Molina‐Barceló, Ana, additional, Jiménez‐Moleón, José‐Juan, additional, Tardón, Adonina, additional, Contreras‐Llanes, Manuel, additional, Marcos‐Gragera, Rafael, additional, Huerta, José Mª, additional, Pérez‐Gómez, Beatriz, additional, Espinosa, Ana, additional, Hernández‐Segura, Natalia, additional, Obón‐Santacana, Mireia, additional, Alonso‐Molero, Jessica, additional, Burgui, Rosana, additional, Amiano, Pilar, additional, Pinto‐Carbó, Marina, additional, Olmedo‐Requena, Rocio, additional, Fernández‐Tardón, Guillermo, additional, Santos‐Sánchez, Vanessa, additional, Fernández de Larrea‐Baz, Nerea, additional, Fernández‐Villa, Tania, additional, Casabonne, Delphine, additional, Dierssen‐Sotos, Trinidad, additional, Ardanaz, Eva, additional, Dorronsoro, Ane, additional, Pollán, Marina, additional, Kogevinas, Manolis, additional, and Lassale, Camille, additional

Published
2023
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20. Do GWAS-Identified Risk Variants for Chronic Lymphocytic Leukemia Influence Overall Patient Survival and Disease Progression?

Author

Cabrera-Serrano, Antonio José, primary, Sánchez-Maldonado, José Manuel, additional, ter Horst, Rob, additional, Macauda, Angelica, additional, García-Martín, Paloma, additional, Benavente, Yolanda, additional, Landi, Stefano, additional, Clay-Gilmour, Alyssa, additional, Niazi, Yasmeen, additional, Espinet, Blanca, additional, Rodríguez-Sevilla, Juan José, additional, Pérez, Eva María, additional, Maffei, Rossana, additional, Blanco, Gonzalo, additional, Giaccherini, Matteo, additional, Cerhan, James R., additional, Marasca, Roberto, additional, López-Nevot, Miguel Ángel, additional, Chen-Liang, Tzu, additional, Thomsen, Hauke, additional, Gámez, Irene, additional, Campa, Daniele, additional, Moreno, Víctor, additional, de Sanjosé, Silvia, additional, Marcos-Gragera, Rafael, additional, García-Álvarez, María, additional, Dierssen-Sotos, Trinidad, additional, Jerez, Andrés, additional, Butrym, Aleksandra, additional, Norman, Aaron D., additional, Luppi, Mario, additional, Slager, Susan L., additional, Hemminki, Kari, additional, Li, Yang, additional, Berndt, Sonja I., additional, Casabonne, Delphine, additional, Alcoceba, Miguel, additional, Puiggros, Anna, additional, Netea, Mihai G., additional, Försti, Asta, additional, Canzian, Federico, additional, and Sainz, Juan, additional

Published
2023
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21. Correction: Distinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes

Author

Berndt, Sonja I, Vijai, Joseph, Benavente, Yolanda, Camp, Nicola J, Nieters, Alexandra, Wang, Zhaoming, Smedby, Karin E, Kleinstern, Geffen, Hjalgrim, Henrik, Besson, Caroline, Skibola, Christine F, Morton, Lindsay M, Brooks-Wilson, Angela R, Teras, Lauren R, Breeze, Charles, Arias, Joshua, Adami, Hans-Olov, Albanes, Demetrius, Anderson, Kenneth C, Ansell, Stephen M, Bassig, Bryan, Becker, Nikolaus, Bhatti, Parveen, Birmann, Brenda M, Boffetta, Paolo, Bracci, Paige M, Brennan, Paul, Brown, Elizabeth E, Burdett, Laurie, Cannon-Albright, Lisa A, Chang, Ellen T, Chiu, Brian C H, Chung, Charles C, Clavel, Jacqueline, Cocco, Pierluigi, Colditz, Graham, Conde, Lucia, Conti, David V, Cox, David G, Curtin, Karen, Casabonne, Delphine, De Vivo, Immaculata, Diepstra, Arjan, Diver, W Ryan, Dogan, Ahmet, Edlund, Christopher K, Foretova, Lenka, Fraumeni, Joseph F, Gabbas, Attilio, Ghesquières, Hervé, Giles, Graham G, Glaser, Sally, Glenn, Martha, Glimelius, Bengt, Gu, Jian, Habermann, Thomas M, Haiman, Christopher A, Haioun, Corinne, Hofmann, Jonathan N, Holford, Theodore R, Holly, Elizabeth A, Hutchinson, Amy, Izhar, Aalin, Jackson, Rebecca D, Jarrett, Ruth F, Kaaks, Rudolph, Kane, Eleanor, Kolonel, Laurence N, Kong, Yinfei, Kraft, Peter, Kricker, Anne, Lake, Annette, Lan, Qing, Lawrence, Charles, Li, Dalin, Liebow, Mark, Link, Brian K, Magnani, Corrado, Maynadie, Marc, McKay, James, Melbye, Mads, Miligi, Lucia, Milne, Roger L, Molina, Thierry J, Monnereau, Alain, Montalvan, Rebecca, North, Kari E, Novak, Anne J, Onel, Kenan, Purdue, Mark P, Rand, Kristin A, Riboli, Elio, Riby, Jacques, Roman, Eve, Salles, Gilles, Sborov, Douglas W, Severson, Richard K, Shanafelt, Tait D, Smith, Martyn T, Smith, Alexandra, Song, Kevin W, Song, Lei, Southey, Melissa C, Spinelli, John J, Staines, Anthony, Stephens, Deborah, Sutherland, Heather J, Tkachuk, Kaitlyn, Thompson, Carrie A, Tilly, Hervé, Tinker, Lesley F, Travis, Ruth C, Turner, Jenny, Vachon, Celine M, Vajdic, Claire M, Van Den Berg, Anke, Van Den Berg, David J, Vermeulen, Roel C H, Vineis, Paolo, Wang, Sophia S, Weiderpass, Elisabete, Weiner, George J, Weinstein, Stephanie, Doo, Nicole Wong, Ye, Yuanqing, Yeager, Meredith, Yu, Kai, Zeleniuch-Jacquotte, Anne, Zhang, Yawei, Zheng, Tongzhang, Ziv, Elad, Sampson, Joshua, Chatterjee, Nilanjan, Offit, Kenneth, Cozen, Wendy, Wu, Xifeng, Cerhan, James R, Chanock, Stephen J, Slager, Susan L, Rothman, Nathaniel, Berndt, Sonja I, Vijai, Joseph, Benavente, Yolanda, Camp, Nicola J, Nieters, Alexandra, Wang, Zhaoming, Smedby, Karin E, Kleinstern, Geffen, Hjalgrim, Henrik, Besson, Caroline, Skibola, Christine F, Morton, Lindsay M, Brooks-Wilson, Angela R, Teras, Lauren R, Breeze, Charles, Arias, Joshua, Adami, Hans-Olov, Albanes, Demetrius, Anderson, Kenneth C, Ansell, Stephen M, Bassig, Bryan, Becker, Nikolaus, Bhatti, Parveen, Birmann, Brenda M, Boffetta, Paolo, Bracci, Paige M, Brennan, Paul, Brown, Elizabeth E, Burdett, Laurie, Cannon-Albright, Lisa A, Chang, Ellen T, Chiu, Brian C H, Chung, Charles C, Clavel, Jacqueline, Cocco, Pierluigi, Colditz, Graham, Conde, Lucia, Conti, David V, Cox, David G, Curtin, Karen, Casabonne, Delphine, De Vivo, Immaculata, Diepstra, Arjan, Diver, W Ryan, Dogan, Ahmet, Edlund, Christopher K, Foretova, Lenka, Fraumeni, Joseph F, Gabbas, Attilio, Ghesquières, Hervé, Giles, Graham G, Glaser, Sally, Glenn, Martha, Glimelius, Bengt, Gu, Jian, Habermann, Thomas M, Haiman, Christopher A, Haioun, Corinne, Hofmann, Jonathan N, Holford, Theodore R, Holly, Elizabeth A, Hutchinson, Amy, Izhar, Aalin, Jackson, Rebecca D, Jarrett, Ruth F, Kaaks, Rudolph, Kane, Eleanor, Kolonel, Laurence N, Kong, Yinfei, Kraft, Peter, Kricker, Anne, Lake, Annette, Lan, Qing, Lawrence, Charles, Li, Dalin, Liebow, Mark, Link, Brian K, Magnani, Corrado, Maynadie, Marc, McKay, James, Melbye, Mads, Miligi, Lucia, Milne, Roger L, Molina, Thierry J, Monnereau, Alain, Montalvan, Rebecca, North, Kari E, Novak, Anne J, Onel, Kenan, Purdue, Mark P, Rand, Kristin A, Riboli, Elio, Riby, Jacques, Roman, Eve, Salles, Gilles, Sborov, Douglas W, Severson, Richard K, Shanafelt, Tait D, Smith, Martyn T, Smith, Alexandra, Song, Kevin W, Song, Lei, Southey, Melissa C, Spinelli, John J, Staines, Anthony, Stephens, Deborah, Sutherland, Heather J, Tkachuk, Kaitlyn, Thompson, Carrie A, Tilly, Hervé, Tinker, Lesley F, Travis, Ruth C, Turner, Jenny, Vachon, Celine M, Vajdic, Claire M, Van Den Berg, Anke, Van Den Berg, David J, Vermeulen, Roel C H, Vineis, Paolo, Wang, Sophia S, Weiderpass, Elisabete, Weiner, George J, Weinstein, Stephanie, Doo, Nicole Wong, Ye, Yuanqing, Yeager, Meredith, Yu, Kai, Zeleniuch-Jacquotte, Anne, Zhang, Yawei, Zheng, Tongzhang, Ziv, Elad, Sampson, Joshua, Chatterjee, Nilanjan, Offit, Kenneth, Cozen, Wendy, Wu, Xifeng, Cerhan, James R, Chanock, Stephen J, Slager, Susan L, and Rothman, Nathaniel

Abstract

Correction to: Leukemia https://doi.org/10.1038/s41375-022-01711-0, published online 22 October 2022

Published
2023

22. Correction: Distinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes

Author

IRAS OH Epidemiology Chemical Agents, IRAS – One Health Chemical, Berndt, Sonja I, Vijai, Joseph, Benavente, Yolanda, Camp, Nicola J, Nieters, Alexandra, Wang, Zhaoming, Smedby, Karin E, Kleinstern, Geffen, Hjalgrim, Henrik, Besson, Caroline, Skibola, Christine F, Morton, Lindsay M, Brooks-Wilson, Angela R, Teras, Lauren R, Breeze, Charles, Arias, Joshua, Adami, Hans-Olov, Albanes, Demetrius, Anderson, Kenneth C, Ansell, Stephen M, Bassig, Bryan, Becker, Nikolaus, Bhatti, Parveen, Birmann, Brenda M, Boffetta, Paolo, Bracci, Paige M, Brennan, Paul, Brown, Elizabeth E, Burdett, Laurie, Cannon-Albright, Lisa A, Chang, Ellen T, Chiu, Brian C H, Chung, Charles C, Clavel, Jacqueline, Cocco, Pierluigi, Colditz, Graham, Conde, Lucia, Conti, David V, Cox, David G, Curtin, Karen, Casabonne, Delphine, De Vivo, Immaculata, Diepstra, Arjan, Diver, W Ryan, Dogan, Ahmet, Edlund, Christopher K, Foretova, Lenka, Fraumeni, Joseph F, Gabbas, Attilio, Ghesquières, Hervé, Giles, Graham G, Glaser, Sally, Glenn, Martha, Glimelius, Bengt, Gu, Jian, Habermann, Thomas M, Haiman, Christopher A, Haioun, Corinne, Hofmann, Jonathan N, Holford, Theodore R, Holly, Elizabeth A, Hutchinson, Amy, Izhar, Aalin, Jackson, Rebecca D, Jarrett, Ruth F, Kaaks, Rudolph, Kane, Eleanor, Kolonel, Laurence N, Kong, Yinfei, Kraft, Peter, Kricker, Anne, Lake, Annette, Lan, Qing, Lawrence, Charles, Li, Dalin, Liebow, Mark, Link, Brian K, Magnani, Corrado, Maynadie, Marc, McKay, James, Melbye, Mads, Miligi, Lucia, Milne, Roger L, Molina, Thierry J, Monnereau, Alain, Montalvan, Rebecca, North, Kari E, Novak, Anne J, Onel, Kenan, Purdue, Mark P, Rand, Kristin A, Riboli, Elio, Riby, Jacques, Roman, Eve, Salles, Gilles, Sborov, Douglas W, Severson, Richard K, Shanafelt, Tait D, Smith, Martyn T, Smith, Alexandra, Song, Kevin W, Song, Lei, Southey, Melissa C, Spinelli, John J, Staines, Anthony, Stephens, Deborah, Sutherland, Heather J, Tkachuk, Kaitlyn, Thompson, Carrie A, Tilly, Hervé, Tinker, Lesley F, Travis, Ruth C, Turner, Jenny, Vachon, Celine M, Vajdic, Claire M, Van Den Berg, Anke, Van Den Berg, David J, Vermeulen, Roel C H, Vineis, Paolo, Wang, Sophia S, Weiderpass, Elisabete, Weiner, George J, Weinstein, Stephanie, Doo, Nicole Wong, Ye, Yuanqing, Yeager, Meredith, Yu, Kai, Zeleniuch-Jacquotte, Anne, Zhang, Yawei, Zheng, Tongzhang, Ziv, Elad, Sampson, Joshua, Chatterjee, Nilanjan, Offit, Kenneth, Cozen, Wendy, Wu, Xifeng, Cerhan, James R, Chanock, Stephen J, Slager, Susan L, Rothman, Nathaniel, IRAS OH Epidemiology Chemical Agents, IRAS – One Health Chemical, Berndt, Sonja I, Vijai, Joseph, Benavente, Yolanda, Camp, Nicola J, Nieters, Alexandra, Wang, Zhaoming, Smedby, Karin E, Kleinstern, Geffen, Hjalgrim, Henrik, Besson, Caroline, Skibola, Christine F, Morton, Lindsay M, Brooks-Wilson, Angela R, Teras, Lauren R, Breeze, Charles, Arias, Joshua, Adami, Hans-Olov, Albanes, Demetrius, Anderson, Kenneth C, Ansell, Stephen M, Bassig, Bryan, Becker, Nikolaus, Bhatti, Parveen, Birmann, Brenda M, Boffetta, Paolo, Bracci, Paige M, Brennan, Paul, Brown, Elizabeth E, Burdett, Laurie, Cannon-Albright, Lisa A, Chang, Ellen T, Chiu, Brian C H, Chung, Charles C, Clavel, Jacqueline, Cocco, Pierluigi, Colditz, Graham, Conde, Lucia, Conti, David V, Cox, David G, Curtin, Karen, Casabonne, Delphine, De Vivo, Immaculata, Diepstra, Arjan, Diver, W Ryan, Dogan, Ahmet, Edlund, Christopher K, Foretova, Lenka, Fraumeni, Joseph F, Gabbas, Attilio, Ghesquières, Hervé, Giles, Graham G, Glaser, Sally, Glenn, Martha, Glimelius, Bengt, Gu, Jian, Habermann, Thomas M, Haiman, Christopher A, Haioun, Corinne, Hofmann, Jonathan N, Holford, Theodore R, Holly, Elizabeth A, Hutchinson, Amy, Izhar, Aalin, Jackson, Rebecca D, Jarrett, Ruth F, Kaaks, Rudolph, Kane, Eleanor, Kolonel, Laurence N, Kong, Yinfei, Kraft, Peter, Kricker, Anne, Lake, Annette, Lan, Qing, Lawrence, Charles, Li, Dalin, Liebow, Mark, Link, Brian K, Magnani, Corrado, Maynadie, Marc, McKay, James, Melbye, Mads, Miligi, Lucia, Milne, Roger L, Molina, Thierry J, Monnereau, Alain, Montalvan, Rebecca, North, Kari E, Novak, Anne J, Onel, Kenan, Purdue, Mark P, Rand, Kristin A, Riboli, Elio, Riby, Jacques, Roman, Eve, Salles, Gilles, Sborov, Douglas W, Severson, Richard K, Shanafelt, Tait D, Smith, Martyn T, Smith, Alexandra, Song, Kevin W, Song, Lei, Southey, Melissa C, Spinelli, John J, Staines, Anthony, Stephens, Deborah, Sutherland, Heather J, Tkachuk, Kaitlyn, Thompson, Carrie A, Tilly, Hervé, Tinker, Lesley F, Travis, Ruth C, Turner, Jenny, Vachon, Celine M, Vajdic, Claire M, Van Den Berg, Anke, Van Den Berg, David J, Vermeulen, Roel C H, Vineis, Paolo, Wang, Sophia S, Weiderpass, Elisabete, Weiner, George J, Weinstein, Stephanie, Doo, Nicole Wong, Ye, Yuanqing, Yeager, Meredith, Yu, Kai, Zeleniuch-Jacquotte, Anne, Zhang, Yawei, Zheng, Tongzhang, Ziv, Elad, Sampson, Joshua, Chatterjee, Nilanjan, Offit, Kenneth, Cozen, Wendy, Wu, Xifeng, Cerhan, James R, Chanock, Stephen J, Slager, Susan L, and Rothman, Nathaniel

Published
2023

23. Do GWAS-Identified Risk Variants for Chronic Lymphocytic Leukemia Influence Overall Patient Survival and Disease Progression?

Author

European Commission, Instituto de Salud Carlos III, Junta de Andalucía, National Cancer Institute (US), Cabrera Serrano, Antonio José, Sánchez Maldonado, José Manuel, Ter Horst, Rob, Macauda, Angelica, García-Martín, Paloma, Benavente, Yolanda, Landi, Stefano, Clay-Gilmour, Alyssa, Niazi, Yasmeen, Espinet, Blanca, Rodríguez-Sevilla, Juan José, Pérez, Eva María, Maffei, Rossana, Blanco, Gonzalo, Giaccherini, Matteo, Cerhan, James R, Marasca, Roberto, López-Nevot, Miguel Ángel, Chen-Liang, Tzu, Thomsen, Hauke, Gámez, Irene, Campa, Daniele, Moreno, Víctor, Sanjosé, Silvia de, Marcos-Gragera, Rafael, García-Alvarez, María, Dierssen-Sotos, Trinidad, Jerez, Andrés, Butrym, Aleksandra, Norman, Aaron D., Luppi, Mario, Slager, Susan L., Hemminki, Kari, Li, Yang, Berndt, Sonja I., Casabonne, Delphine, Alcoceba, Miguel, Puiggros, Anna, Netea, Mihai G., Försti, Asta, Canzian, Federico, Sainz, Juan, European Commission, Instituto de Salud Carlos III, Junta de Andalucía, National Cancer Institute (US), Cabrera Serrano, Antonio José, Sánchez Maldonado, José Manuel, Ter Horst, Rob, Macauda, Angelica, García-Martín, Paloma, Benavente, Yolanda, Landi, Stefano, Clay-Gilmour, Alyssa, Niazi, Yasmeen, Espinet, Blanca, Rodríguez-Sevilla, Juan José, Pérez, Eva María, Maffei, Rossana, Blanco, Gonzalo, Giaccherini, Matteo, Cerhan, James R, Marasca, Roberto, López-Nevot, Miguel Ángel, Chen-Liang, Tzu, Thomsen, Hauke, Gámez, Irene, Campa, Daniele, Moreno, Víctor, Sanjosé, Silvia de, Marcos-Gragera, Rafael, García-Alvarez, María, Dierssen-Sotos, Trinidad, Jerez, Andrés, Butrym, Aleksandra, Norman, Aaron D., Luppi, Mario, Slager, Susan L., Hemminki, Kari, Li, Yang, Berndt, Sonja I., Casabonne, Delphine, Alcoceba, Miguel, Puiggros, Anna, Netea, Mihai G., Försti, Asta, Canzian, Federico, and Sainz, Juan

Abstract

Chronic lymphocytic leukemia (CLL) is the most common leukemia among adults worldwide. Although genome-wide association studies (GWAS) have uncovered the germline genetic component underlying CLL susceptibility, the potential use of GWAS-identified risk variants to predict disease progression and patient survival remains unexplored. Here, we evaluated whether 41 GWAS-identified risk variants for CLL could influence overall survival (OS) and disease progression, defined as time to first treatment (TTFT) in a cohort of 1039 CLL cases ascertained through the CRuCIAL consortium. Although this is the largest study assessing the effect of GWAS-identified susceptibility variants for CLL on OS, we only found a weak association of ten single nucleotide polymorphisms (SNPs) with OS (p < 0.05) that did not remain significant after correction for multiple testing. In line with these results, polygenic risk scores (PRSs) built with these SNPs in the CRuCIAL cohort showed a modest association with OS and a low capacity to predict patient survival, with an area under the receiver operating characteristic curve (AUROC) of 0.57. Similarly, seven SNPs were associated with TTFT (p < 0.05); however, these did not reach the multiple testing significance threshold, and the meta-analysis with previous published data did not confirm any of the associations. As expected, PRSs built with these SNPs showed reduced accuracy in prediction of disease progression (AUROC = 0.62). These results suggest that susceptibility variants for CLL do not impact overall survival and disease progression in CLL patients.

Published
2023

24. Helicobacter pylori seroprevalence in Spain: influence of adult and childhood sociodemographic factors

Author

Lorenzo, Irene, Fernández-de-Larrea, Nerea, Michel, Angelika, Romero, Beatriz, Lope, Virginia, Bessa, Xavier, Moreno, Victor, Martín, Vicente, Amiano, Pilar, Castilla, Jesús, Tardón, Adonina, Dierssen-Sotos, Trinidad, Peiró, Rosana, Díaz-Santos, Marian, Navarro, Carmen, Jiménez-Moleón, José J., Butt, Julia, Barricarte, Aurelio, Ruiz, Irune, Molina-de-la-Torre, Antonio J., Casabonne, Delphine, Pérez-Gómez, Beatriz, Kogevinas, Manolis, del Campo, Rosa, de Sanjosé, Silvia, Pollán, Marina, Waterboer, Tim, and Aragonés, Nuria

Published
2019
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27. Fruit and vegetable intake and vitamin C transporter gene (SLC23A2) polymorphisms in chronic lymphocytic leukaemia

Author

Casabonne, Delphine, Gracia, Esther, Espinosa, Ana, Bustamante, Mariona, Benavente, Yolanda, Robles, Claudia, Costas, Laura, Alonso, Esther, Gonzalez-Barca, Eva, Tardón, Adonina, Dierssen-Sotos, Trinidad, Vázquez, Eva Gimeno, Aymerich, Marta, Campo, Elies, Jiménez-Moleón, José J., Marcos-Gragera, Rafael, Castaño-Vinyals, Gemma, Aragones, Nuria, Pollan, Marina, Kogevinas, Manolis, Urtiaga, Carmen, Amiano, Pilar, Moreno, Victor, and de Sanjose, Silvia

Published
2017
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28. Herbicide use in farming and other jobs in relation to non-Hodgkin’s lymphoma (NHL) risk

Author

De Roos, Anneclaire J, primary, Fritschi, Lin, additional, Ward, Mary H, additional, Monnereau, Alain, additional, Hofmann, Jonathan, additional, Bernstein, Leslie, additional, Bhatti, Parveen, additional, Benavente Moreno, Yolanda, additional, Benke, Geza, additional, Casabonne, Delphine, additional, Clavel, Jacqueline, additional, Cocco, Pierluigi, additional, Huynh, Tran, additional, 't Mannetje, Andrea, additional, Miligi, Lucia, additional, Piro, Sara, additional, Rothman, Nathaniel, additional, Schinasi, Leah H, additional, Vajdic, Claire M, additional, Wang, Sophia S, additional, Zhang, Yawei, additional, Slager, Susan L, additional, and Cerhan, James R, additional

Published
2022
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29. Antibody reactivity against Helicobacter pylori proteins in a sample of the Spanish adult population in 2008‐2013

Author

Fernández‐de‐Larrea, Nerea, Michel, Angelika, Romero, Beatriz, Butt, Julia, Pawlita, Michael, Pérez‐Gómez, Beatriz, Castaño‐Vinyals, Gemma, Moreno, Victor, Martín, Vicente, Amiano, Pilar, Castilla, Jesús, Fernández‐Tardón, Guillermo, Dierssen‐Sotos, Trinidad, Clofent, Juan, Alguacil, Juan, Huerta, José María, Jiménez‐Moleón, José Juan, Barricarte, Aurelio, Molinuevo, Amaia, Fernández‐Villa, Tania, Casabonne, Delphine, Sierra, Ángeles, Kogevinas, Manolis, de Sanjosé, Silvia, Pollán, Marina, del Campo, Rosa, Waterboer, Tim, and Aragonés, Nuria

Published
2017
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31. Physical activity and the risk of non‐Hodgkin lymphoma subtypes: A pooled analysis

Author

Boyle, Terry, primary, Kleinstern, Geffen, additional, Bracci, Paige M., additional, Cerhan, James R., additional, Benavente, Yolanda, additional, Casabonne, Delphine, additional, Chiu, Brian C.‐H., additional, Habermann, Thomas M., additional, Holly, Elizabeth A., additional, Liebow, Mark, additional, Norman, Aaron, additional, Paltiel, Ora, additional, Robinson, Dennis, additional, Rothman, Nathaniel, additional, Abu Seir, Rania, additional, Slager, Susan L., additional, Villeneuve, Paul J., additional, Wang, Sophia S., additional, Weisenburger, Dennis D., additional, and Spinelli, John J., additional

Published
2022
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32. High-risk subtypes of chronic lymphocytic leukemia are detectable as early as 16 years prior to diagnosis

Author

Kolijn, Martijn, Saberi Hosnijeh, Fatemeh, Spath, Florentin, Hengeveld, P., Andreas, Agathangelidis, Saleh, Manal, Casabonne, Delphine, Benavente, Yolanda, Jerkeman, Mats, Aguado, Antonio, Barricante, Aurelio, Besson, Caroline M, Sanchez , Maria-Jose, Chirlaque, Maria Dolores, Masala, Giovanna, Sacerdote, Carlotta, Grioni, Sara, Schulze, M.B., Nieters, Alexandra, Engelfriet, Peter M, Hultdin, Magnus, McKay, J., Vermeulen, Roel, Langerak, Anton W, Kolijn, Martijn, Saberi Hosnijeh, Fatemeh, Spath, Florentin, Hengeveld, P., Andreas, Agathangelidis, Saleh, Manal, Casabonne, Delphine, Benavente, Yolanda, Jerkeman, Mats, Aguado, Antonio, Barricante, Aurelio, Besson, Caroline M, Sanchez , Maria-Jose, Chirlaque, Maria Dolores, Masala, Giovanna, Sacerdote, Carlotta, Grioni, Sara, Schulze, M.B., Nieters, Alexandra, Engelfriet, Peter M, Hultdin, Magnus, McKay, J., Vermeulen, Roel, and Langerak, Anton W

Abstract

Chronic lymphocytic leukemia (CLL) is preceded by monoclonal B-cell lymphocytosis (MBL), a CLL precursor state with a prevalence of up to 12% in aged individuals; however, the duration of MBL and the mechanisms of its evolution to CLL remain largely unknown. In this study, we sequenced the B-cell receptor (BcR) immunoglobulin heavy chain (IGH) gene repertoire of 124 patients with CLL and 118 matched controls in blood samples taken up to 22 years prior to diagnosis. Significant skewing in the BcR IGH gene repertoire was detected in the majority of patients, even before the occurrence of lymphocytosis and irrespective of the clonotypic IGH variable gene somatic hypermutation status. Furthermore, we identified dominant clonotypes belonging to major stereotyped subsets associated with poor prognosis up to 16 years before diagnosis in 14 patients with CLL. In 22 patients with longitudinal samples, the skewing of the BcR IGH gene repertoire increased significantly over time to diagnosis or remained stable at high levels. For 14 of 16 patients with available samples at diagnosis, the CLL clonotype was already present in the prediagnostic samples. Overall, our data indicate that the preclinical phase of CLL could be longer than previously thought, even in adverse-prognostic cases.

Published
2022

33. Distinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes

Author

Berndt, Sonja I, Vijai, Joseph, Benavente, Yolanda, Camp, Nicola J, Nieters, Alexandra, Wang, Zhaoming, Smedby, Karin E, Kleinstern, Geffen, Hjalgrim, Henrik, Besson, Caroline, Skibola, Christine F, Morton, Lindsay M, Brooks-Wilson, Angela R, Teras, Lauren R, Breeze, Charles, Arias, Joshua, Adami, Hans-Olov, Albanes, Demetrius, Anderson, Kenneth C, Ansell, Stephen M, Bassig, Bryan, Becker, Nikolaus, Bhatti, Parveen, Birmann, Brenda M, Boffetta, Paolo, Bracci, Paige M, Brennan, Paul, Brown, Elizabeth E, Burdett, Laurie, Cannon-Albright, Lisa A, Chang, Ellen T, Chiu, Brian C H, Chung, Charles C, Clavel, Jacqueline, Cocco, Pierluigi, Colditz, Graham, Conde, Lucia, Conti, David V, Cox, David G, Curtin, Karen, Casabonne, Delphine, De Vivo, Immaculata, Diver, W Ryan, Dogan, Ahmet, Edlund, Christopher K, Foretova, Lenka, Fraumeni, Joseph F, Gabbas, Attilio, Ghesquières, Hervé, Giles, Graham G, Glaser, Sally, Glenn, Martha, Glimelius, Bengt, Gu, Jian, Habermann, Thomas M, Haiman, Christopher A, Haioun, Corinne, Hofmann, Jonathan N, Holford, Theodore R, Holly, Elizabeth A, Hutchinson, Amy, Izhar, Aalin, Jackson, Rebecca D, Jarrett, Ruth F, Kaaks, Rudolph, Kane, Eleanor, Kolonel, Laurence N, Kong, Yinfei, Kraft, Peter, Kricker, Anne, Lake, Annette, Lan, Qing, Lawrence, Charles, Li, Dalin, Liebow, Mark, Link, Brian K, Magnani, Corrado, Maynadie, Marc, McKay, James, Melbye, Mads, Miligi, Lucia, Milne, Roger L, Molina, Thierry J, Monnereau, Alain, Montalvan, Rebecca, North, Kari E, Novak, Anne J, Onel, Kenan, Purdue, Mark P, Rand, Kristin A, Riboli, Elio, Riby, Jacques, Roman, Eve, Salles, Gilles, Sborov, Douglas W, Severson, Richard K, Shanafelt, Tait D, Smith, Martyn T, Smith, Alexandra, Song, Kevin W, Song, Lei, Southey, Melissa C, Spinelli, John J, Staines, Anthony, Stephens, Deborah, Sutherland, Heather J, Tkachuk, Kaitlyn, Thompson, Carrie A, Tilly, Hervé, Tinker, Lesley F, Travis, Ruth C, Turner, Jenny, Vachon, Celine M, Vajdic, Claire M, Van Den Berg, Anke, Van Den Berg, David J, Vermeulen, Roel C H, Vineis, Paolo, Wang, Sophia S, Weiderpass, Elisabete, Weiner, George J, Weinstein, Stephanie, Doo, Nicole Wong, Ye, Yuanqing, Yeager, Meredith, Yu, Kai, Zeleniuch-Jacquotte, Anne, Zhang, Yawei, Zheng, Tongzhang, Ziv, Elad, Sampson, Joshua, Chatterjee, Nilanjan, Offit, Kenneth, Cozen, Wendy, Wu, Xifeng, Cerhan, James R, Chanock, Stephen J, Slager, Susan L, Rothman, Nathaniel, Berndt, Sonja I, Vijai, Joseph, Benavente, Yolanda, Camp, Nicola J, Nieters, Alexandra, Wang, Zhaoming, Smedby, Karin E, Kleinstern, Geffen, Hjalgrim, Henrik, Besson, Caroline, Skibola, Christine F, Morton, Lindsay M, Brooks-Wilson, Angela R, Teras, Lauren R, Breeze, Charles, Arias, Joshua, Adami, Hans-Olov, Albanes, Demetrius, Anderson, Kenneth C, Ansell, Stephen M, Bassig, Bryan, Becker, Nikolaus, Bhatti, Parveen, Birmann, Brenda M, Boffetta, Paolo, Bracci, Paige M, Brennan, Paul, Brown, Elizabeth E, Burdett, Laurie, Cannon-Albright, Lisa A, Chang, Ellen T, Chiu, Brian C H, Chung, Charles C, Clavel, Jacqueline, Cocco, Pierluigi, Colditz, Graham, Conde, Lucia, Conti, David V, Cox, David G, Curtin, Karen, Casabonne, Delphine, De Vivo, Immaculata, Diver, W Ryan, Dogan, Ahmet, Edlund, Christopher K, Foretova, Lenka, Fraumeni, Joseph F, Gabbas, Attilio, Ghesquières, Hervé, Giles, Graham G, Glaser, Sally, Glenn, Martha, Glimelius, Bengt, Gu, Jian, Habermann, Thomas M, Haiman, Christopher A, Haioun, Corinne, Hofmann, Jonathan N, Holford, Theodore R, Holly, Elizabeth A, Hutchinson, Amy, Izhar, Aalin, Jackson, Rebecca D, Jarrett, Ruth F, Kaaks, Rudolph, Kane, Eleanor, Kolonel, Laurence N, Kong, Yinfei, Kraft, Peter, Kricker, Anne, Lake, Annette, Lan, Qing, Lawrence, Charles, Li, Dalin, Liebow, Mark, Link, Brian K, Magnani, Corrado, Maynadie, Marc, McKay, James, Melbye, Mads, Miligi, Lucia, Milne, Roger L, Molina, Thierry J, Monnereau, Alain, Montalvan, Rebecca, North, Kari E, Novak, Anne J, Onel, Kenan, Purdue, Mark P, Rand, Kristin A, Riboli, Elio, Riby, Jacques, Roman, Eve, Salles, Gilles, Sborov, Douglas W, Severson, Richard K, Shanafelt, Tait D, Smith, Martyn T, Smith, Alexandra, Song, Kevin W, Song, Lei, Southey, Melissa C, Spinelli, John J, Staines, Anthony, Stephens, Deborah, Sutherland, Heather J, Tkachuk, Kaitlyn, Thompson, Carrie A, Tilly, Hervé, Tinker, Lesley F, Travis, Ruth C, Turner, Jenny, Vachon, Celine M, Vajdic, Claire M, Van Den Berg, Anke, Van Den Berg, David J, Vermeulen, Roel C H, Vineis, Paolo, Wang, Sophia S, Weiderpass, Elisabete, Weiner, George J, Weinstein, Stephanie, Doo, Nicole Wong, Ye, Yuanqing, Yeager, Meredith, Yu, Kai, Zeleniuch-Jacquotte, Anne, Zhang, Yawei, Zheng, Tongzhang, Ziv, Elad, Sampson, Joshua, Chatterjee, Nilanjan, Offit, Kenneth, Cozen, Wendy, Wu, Xifeng, Cerhan, James R, Chanock, Stephen J, Slager, Susan L, and Rothman, Nathaniel

Abstract

Lymphoma risk is elevated for relatives with common non-Hodgkin lymphoma (NHL) subtypes, suggesting shared genetic susceptibility across subtypes. To evaluate the extent of mutual heritability among NHL subtypes and discover novel loci shared among subtypes, we analyzed data from eight genome-wide association studies within the InterLymph Consortium, including 10,629 cases and 9505 controls. We utilized Association analysis based on SubSETs (ASSET) to discover loci for subsets of NHL subtypes and evaluated shared heritability across the genome using Genome-wide Complex Trait Analysis (GCTA) and polygenic risk scores. We discovered 17 genome-wide significant loci (P < 5 × 10−8) for subsets of NHL subtypes, including a novel locus at 10q23.33 (HHEX) (P = 3.27 × 10−9). Most subset associations were driven primarily by only one subtype. Genome-wide genetic correlations between pairs of subtypes varied broadly from 0.20 to 0.86, suggesting substantial heterogeneity in the extent of shared heritability among subtypes. Polygenic risk score analyses of established loci for different lymphoid malignancies identified strong associations with some NHL subtypes (P < 5 × 10−8), but weak or null associations with others. Although our analyses suggest partially shared heritability and biological pathways, they reveal substantial heterogeneity among NHL subtypes with each having its own distinct germline genetic architecture.

Published
2022

34. Distinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes

Author

Berndt, Sonja, I, Vijai, Joseph, Benavente, Yolanda, Camp, Nicola J., Nieters, Alexandra, Wang, Zhaoming, Smedby, Karin E., Kleinstern, Geffen, Hjalgrim, Henrik, Besson, Caroline, Skibola, Christine F., Morton, Lindsay M., Brooks-Wilson, Angela R., Teras, Lauren R., Breeze, Charles, Arias, Joshua, Adami, Hans-Olov, Albanes, Demetrius, Anderson, Kenneth C., Ansell, Stephen M., Bassig, Bryan, Becker, Nikolaus, Bhatti, Parveen, Birmann, Brenda M., Boffetta, Paolo, Bracci, Paige M., Brennan, Paul, Brown, Elizabeth E., Burdett, Laurie, Cannon-Albright, Lisa A., Chang, Ellen T., Chiu, Brian C. H., Chung, Charles C., Clavel, Jacqueline, Cocco, Pierluigi, Colditz, Graham, Conde, Lucia, Conti, David, V, Cox, David G., Curtin, Karen, Casabonne, Delphine, De Vivo, Immaculata, Diver, W. Ryan, Dogan, Ahmet, Edlund, Christopher K., Foretova, Lenka, Fraumeni, Joseph F., Jr., Gabbas, Attilio, Ghesquieres, Herve, Giles, Graham G., Glaser, Sally, Glenn, Martha, Glimelius, Bengt, Gu, Jian, Habermann, Thomas M., Haiman, Christopher A., Haioun, Corinne, Hofmann, Jonathan N., Holford, Theodore R., Holly, Elizabeth A., Hutchinson, Amy, Izhar, Aalin, Jackson, Rebecca D., Jarrett, Ruth F., Kaaks, Rudolph, Kane, Eleanor, Kolonel, Laurence N., Kong, Yinfei, Kraft, Peter, Kricker, Anne, Lake, Annette, Lan, Qing, Lawrence, Charles, Li, Dalin, Liebow, Mark, Link, Brian K., Magnani, Corrado, Maynadie, Marc, McKay, James, Melbye, Mads, Miligi, Lucia, Milne, Roger L., Molina, Thierry J., Monnereau, Alain, Montalvan, Rebecca, North, Kari E., Novak, Anne J., Onel, Kenan, Purdue, Mark P., Rand, Kristin A., Riboli, Elio, Riby, Jacques, Roman, Eve, Salles, Gilles, Sborov, Douglas W., Severson, Richard K., Shanafelt, Tait D., Smith, Martyn T., Smith, Alexandra, Song, Kevin W., Song, Lei, Southey, Melissa C., Spinelli, John J., Staines, Anthony, Stephens, Deborah, Sutherland, Heather J., Tkachuk, Kaitlyn, Thompson, Carrie A., Tilly, Herve, Tinker, Lesley F., Travis, Ruth C., Turner, Jenny, Vachon, Celine M., Vajdic, Claire M., Van den Berg, Anke, Van den Berg, David J., Vermeulen, Roel C. H., Vineis, Paolo, Wang, Sophia S., Weiderpass, Elisabete, Weiner, George J., Weinstein, Stephanie, Doo, Nicole Wong, Ye, Yuanqing, Yeager, Meredith, Yu, Kai, Zeleniuch-Jacquotte, Anne, Zhang, Yawei, Zheng, Tongzhang, Ziv, Elad, Sampson, Joshua, Chatterjee, Nilanjan, Offit, Kenneth, Cozen, Wendy, Wu, Xifeng, Cerhan, James R., Chanock, Stephen J., Slager, Susan L., Rothman, Nathaniel, Berndt, Sonja, I, Vijai, Joseph, Benavente, Yolanda, Camp, Nicola J., Nieters, Alexandra, Wang, Zhaoming, Smedby, Karin E., Kleinstern, Geffen, Hjalgrim, Henrik, Besson, Caroline, Skibola, Christine F., Morton, Lindsay M., Brooks-Wilson, Angela R., Teras, Lauren R., Breeze, Charles, Arias, Joshua, Adami, Hans-Olov, Albanes, Demetrius, Anderson, Kenneth C., Ansell, Stephen M., Bassig, Bryan, Becker, Nikolaus, Bhatti, Parveen, Birmann, Brenda M., Boffetta, Paolo, Bracci, Paige M., Brennan, Paul, Brown, Elizabeth E., Burdett, Laurie, Cannon-Albright, Lisa A., Chang, Ellen T., Chiu, Brian C. H., Chung, Charles C., Clavel, Jacqueline, Cocco, Pierluigi, Colditz, Graham, Conde, Lucia, Conti, David, V, Cox, David G., Curtin, Karen, Casabonne, Delphine, De Vivo, Immaculata, Diver, W. Ryan, Dogan, Ahmet, Edlund, Christopher K., Foretova, Lenka, Fraumeni, Joseph F., Jr., Gabbas, Attilio, Ghesquieres, Herve, Giles, Graham G., Glaser, Sally, Glenn, Martha, Glimelius, Bengt, Gu, Jian, Habermann, Thomas M., Haiman, Christopher A., Haioun, Corinne, Hofmann, Jonathan N., Holford, Theodore R., Holly, Elizabeth A., Hutchinson, Amy, Izhar, Aalin, Jackson, Rebecca D., Jarrett, Ruth F., Kaaks, Rudolph, Kane, Eleanor, Kolonel, Laurence N., Kong, Yinfei, Kraft, Peter, Kricker, Anne, Lake, Annette, Lan, Qing, Lawrence, Charles, Li, Dalin, Liebow, Mark, Link, Brian K., Magnani, Corrado, Maynadie, Marc, McKay, James, Melbye, Mads, Miligi, Lucia, Milne, Roger L., Molina, Thierry J., Monnereau, Alain, Montalvan, Rebecca, North, Kari E., Novak, Anne J., Onel, Kenan, Purdue, Mark P., Rand, Kristin A., Riboli, Elio, Riby, Jacques, Roman, Eve, Salles, Gilles, Sborov, Douglas W., Severson, Richard K., Shanafelt, Tait D., Smith, Martyn T., Smith, Alexandra, Song, Kevin W., Song, Lei, Southey, Melissa C., Spinelli, John J., Staines, Anthony, Stephens, Deborah, Sutherland, Heather J., Tkachuk, Kaitlyn, Thompson, Carrie A., Tilly, Herve, Tinker, Lesley F., Travis, Ruth C., Turner, Jenny, Vachon, Celine M., Vajdic, Claire M., Van den Berg, Anke, Van den Berg, David J., Vermeulen, Roel C. H., Vineis, Paolo, Wang, Sophia S., Weiderpass, Elisabete, Weiner, George J., Weinstein, Stephanie, Doo, Nicole Wong, Ye, Yuanqing, Yeager, Meredith, Yu, Kai, Zeleniuch-Jacquotte, Anne, Zhang, Yawei, Zheng, Tongzhang, Ziv, Elad, Sampson, Joshua, Chatterjee, Nilanjan, Offit, Kenneth, Cozen, Wendy, Wu, Xifeng, Cerhan, James R., Chanock, Stephen J., Slager, Susan L., and Rothman, Nathaniel

Abstract

Lymphoma risk is elevated for relatives with common non-Hodgkin lymphoma (NHL) subtypes, suggesting shared genetic susceptibility across subtypes. To evaluate the extent of mutual heritability among NHL subtypes and discover novel loci shared among subtypes, we analyzed data from eight genome-wide association studies within the InterLymph Consortium, including 10,629 cases and 9505 controls. We utilized Association analysis based on SubSETs (ASSET) to discover loci for subsets of NHL subtypes and evaluated shared heritability across the genome using Genome-wide Complex Trait Analysis (GCTA) and polygenic risk scores. We discovered 17 genome-wide significant loci (P < 5 × 10−8) for subsets of NHL subtypes, including a novel locus at 10q23.33 (HHEX) (P = 3.27 × 10−9). Most subset associations were driven primarily by only one subtype. Genome-wide genetic correlations between pairs of subtypes varied broadly from 0.20 to 0.86, suggesting substantial heterogeneity in the extent of shared heritability among subtypes. Polygenic risk score analyses of established loci for different lymphoid malignancies identified strong associations with some NHL subtypes (P < 5 × 10−8), but weak or null associations with others. Although our analyses suggest partially shared heritability and biological pathways, they reveal substantial heterogeneity among NHL subtypes with each having its own distinct germline genetic architecture., Correction in: Leukemia, vol. 37, issue 10, article ID 2142DOI: 10.1038/s41375-023-01978-x

Published
2022
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35. High-risk subtypes of chronic lymphocytic leukemia are detectable as early as 16 years prior to diagnosis

Author

IRAS OH Epidemiology Chemical Agents, Kolijn, Martijn, Saberi Hosnijeh, Fatemeh, Spath, Florentin, Hengeveld, P., Andreas, Agathangelidis, Saleh, Manal, Casabonne, Delphine, Benavente, Yolanda, Jerkeman, Mats, Aguado, Antonio, Barricante, Aurelio, Besson, Caroline M, Sanchez , Maria-Jose, Chirlaque, Maria Dolores, Masala, Giovanna, Sacerdote, Carlotta, Grioni, Sara, Schulze, M.B., Nieters, Alexandra, Engelfriet, Peter M, Hultdin, Magnus, McKay, J., Vermeulen, Roel, Langerak, Anton W, IRAS OH Epidemiology Chemical Agents, Kolijn, Martijn, Saberi Hosnijeh, Fatemeh, Spath, Florentin, Hengeveld, P., Andreas, Agathangelidis, Saleh, Manal, Casabonne, Delphine, Benavente, Yolanda, Jerkeman, Mats, Aguado, Antonio, Barricante, Aurelio, Besson, Caroline M, Sanchez , Maria-Jose, Chirlaque, Maria Dolores, Masala, Giovanna, Sacerdote, Carlotta, Grioni, Sara, Schulze, M.B., Nieters, Alexandra, Engelfriet, Peter M, Hultdin, Magnus, McKay, J., Vermeulen, Roel, and Langerak, Anton W

Published
2022

36. Distinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes

Author

IRAS OH Epidemiology Chemical Agents, Berndt, Sonja I, Vijai, Joseph, Benavente, Yolanda, Camp, Nicola J, Nieters, Alexandra, Wang, Zhaoming, Smedby, Karin E, Kleinstern, Geffen, Hjalgrim, Henrik, Besson, Caroline, Skibola, Christine F, Morton, Lindsay M, Brooks-Wilson, Angela R, Teras, Lauren R, Breeze, Charles, Arias, Joshua, Adami, Hans-Olov, Albanes, Demetrius, Anderson, Kenneth C, Ansell, Stephen M, Bassig, Bryan, Becker, Nikolaus, Bhatti, Parveen, Birmann, Brenda M, Boffetta, Paolo, Bracci, Paige M, Brennan, Paul, Brown, Elizabeth E, Burdett, Laurie, Cannon-Albright, Lisa A, Chang, Ellen T, Chiu, Brian C H, Chung, Charles C, Clavel, Jacqueline, Cocco, Pierluigi, Colditz, Graham, Conde, Lucia, Conti, David V, Cox, David G, Curtin, Karen, Casabonne, Delphine, De Vivo, Immaculata, Diver, W Ryan, Dogan, Ahmet, Edlund, Christopher K, Foretova, Lenka, Fraumeni, Joseph F, Gabbas, Attilio, Ghesquières, Hervé, Giles, Graham G, Glaser, Sally, Glenn, Martha, Glimelius, Bengt, Gu, Jian, Habermann, Thomas M, Haiman, Christopher A, Haioun, Corinne, Hofmann, Jonathan N, Holford, Theodore R, Holly, Elizabeth A, Hutchinson, Amy, Izhar, Aalin, Jackson, Rebecca D, Jarrett, Ruth F, Kaaks, Rudolph, Kane, Eleanor, Kolonel, Laurence N, Kong, Yinfei, Kraft, Peter, Kricker, Anne, Lake, Annette, Lan, Qing, Lawrence, Charles, Li, Dalin, Liebow, Mark, Link, Brian K, Magnani, Corrado, Maynadie, Marc, McKay, James, Melbye, Mads, Miligi, Lucia, Milne, Roger L, Molina, Thierry J, Monnereau, Alain, Montalvan, Rebecca, North, Kari E, Novak, Anne J, Onel, Kenan, Purdue, Mark P, Rand, Kristin A, Riboli, Elio, Riby, Jacques, Roman, Eve, Salles, Gilles, Sborov, Douglas W, Severson, Richard K, Shanafelt, Tait D, Smith, Martyn T, Smith, Alexandra, Song, Kevin W, Song, Lei, Southey, Melissa C, Spinelli, John J, Staines, Anthony, Stephens, Deborah, Sutherland, Heather J, Tkachuk, Kaitlyn, Thompson, Carrie A, Tilly, Hervé, Tinker, Lesley F, Travis, Ruth C, Turner, Jenny, Vachon, Celine M, Vajdic, Claire M, Van Den Berg, Anke, Van Den Berg, David J, Vermeulen, Roel C H, Vineis, Paolo, Wang, Sophia S, Weiderpass, Elisabete, Weiner, George J, Weinstein, Stephanie, Doo, Nicole Wong, Ye, Yuanqing, Yeager, Meredith, Yu, Kai, Zeleniuch-Jacquotte, Anne, Zhang, Yawei, Zheng, Tongzhang, Ziv, Elad, Sampson, Joshua, Chatterjee, Nilanjan, Offit, Kenneth, Cozen, Wendy, Wu, Xifeng, Cerhan, James R, Chanock, Stephen J, Slager, Susan L, Rothman, Nathaniel, IRAS OH Epidemiology Chemical Agents, Berndt, Sonja I, Vijai, Joseph, Benavente, Yolanda, Camp, Nicola J, Nieters, Alexandra, Wang, Zhaoming, Smedby, Karin E, Kleinstern, Geffen, Hjalgrim, Henrik, Besson, Caroline, Skibola, Christine F, Morton, Lindsay M, Brooks-Wilson, Angela R, Teras, Lauren R, Breeze, Charles, Arias, Joshua, Adami, Hans-Olov, Albanes, Demetrius, Anderson, Kenneth C, Ansell, Stephen M, Bassig, Bryan, Becker, Nikolaus, Bhatti, Parveen, Birmann, Brenda M, Boffetta, Paolo, Bracci, Paige M, Brennan, Paul, Brown, Elizabeth E, Burdett, Laurie, Cannon-Albright, Lisa A, Chang, Ellen T, Chiu, Brian C H, Chung, Charles C, Clavel, Jacqueline, Cocco, Pierluigi, Colditz, Graham, Conde, Lucia, Conti, David V, Cox, David G, Curtin, Karen, Casabonne, Delphine, De Vivo, Immaculata, Diver, W Ryan, Dogan, Ahmet, Edlund, Christopher K, Foretova, Lenka, Fraumeni, Joseph F, Gabbas, Attilio, Ghesquières, Hervé, Giles, Graham G, Glaser, Sally, Glenn, Martha, Glimelius, Bengt, Gu, Jian, Habermann, Thomas M, Haiman, Christopher A, Haioun, Corinne, Hofmann, Jonathan N, Holford, Theodore R, Holly, Elizabeth A, Hutchinson, Amy, Izhar, Aalin, Jackson, Rebecca D, Jarrett, Ruth F, Kaaks, Rudolph, Kane, Eleanor, Kolonel, Laurence N, Kong, Yinfei, Kraft, Peter, Kricker, Anne, Lake, Annette, Lan, Qing, Lawrence, Charles, Li, Dalin, Liebow, Mark, Link, Brian K, Magnani, Corrado, Maynadie, Marc, McKay, James, Melbye, Mads, Miligi, Lucia, Milne, Roger L, Molina, Thierry J, Monnereau, Alain, Montalvan, Rebecca, North, Kari E, Novak, Anne J, Onel, Kenan, Purdue, Mark P, Rand, Kristin A, Riboli, Elio, Riby, Jacques, Roman, Eve, Salles, Gilles, Sborov, Douglas W, Severson, Richard K, Shanafelt, Tait D, Smith, Martyn T, Smith, Alexandra, Song, Kevin W, Song, Lei, Southey, Melissa C, Spinelli, John J, Staines, Anthony, Stephens, Deborah, Sutherland, Heather J, Tkachuk, Kaitlyn, Thompson, Carrie A, Tilly, Hervé, Tinker, Lesley F, Travis, Ruth C, Turner, Jenny, Vachon, Celine M, Vajdic, Claire M, Van Den Berg, Anke, Van Den Berg, David J, Vermeulen, Roel C H, Vineis, Paolo, Wang, Sophia S, Weiderpass, Elisabete, Weiner, George J, Weinstein, Stephanie, Doo, Nicole Wong, Ye, Yuanqing, Yeager, Meredith, Yu, Kai, Zeleniuch-Jacquotte, Anne, Zhang, Yawei, Zheng, Tongzhang, Ziv, Elad, Sampson, Joshua, Chatterjee, Nilanjan, Offit, Kenneth, Cozen, Wendy, Wu, Xifeng, Cerhan, James R, Chanock, Stephen J, Slager, Susan L, and Rothman, Nathaniel

Published
2022

37. Validation and functional characterization of GWAS-identified variants for chronic lymphocytic leukemia: a CRuCIAL study

Author

European Commission, Instituto de Salud Carlos III, Universidad de Granada, Universidad de Sevilla, Generalitat de Catalunya, Gilead Sciences, Associazione Italiana per la Ricerca sul Cancro, Fundación Científica Asociación Española Contra el Cáncer, García-Martín, Paloma, Moñiz Díez, Ana, Sánchez Maldonado, José Manuel, Cabrera Serrano, Antonio José, Horst, Rob ter, Benavente, Yolanda, Landi, Stefano, Macauda, Angelica, Clay-Gilmour, Alyssa, Hernandez-Mohedo, Francisca, Niazi, Yasmeen, González-Sierra, Pedro, Espinet, Blanca, Rodríguez-Sevilla, Juan José, Maffei, Rossana, Blanco, Gonzalo, Giaccherini, Matteo, Puiggros, Anna, Cerhan, James, Marasca, Roberto, Cañadas-Garre, Marisa, López-Nevot, Miguel Ángel, Chen-Liang, Tzu, Thomsen, Hauke, Gámez, Irene, Moreno, Víctor, Marcos-Gragera, Rafael, García-Alvarez, María, Llorca, Javier, Jerez, Andrés, Berndt, Sonja, Butrym, Aleksandra, Norman, Aaron D., Casabonne, Delphine, Luppi, Mario, Slager, Susan L., Hemminki, Kari, Li, Yang, Alcoceba, Miguel, Campa, Daniele, Canzian, Federico, Sanjosé, Silvia de, Försti, Asta, Netea, Mihai, Jurado, Manuel, Sainz, Juan, European Commission, Instituto de Salud Carlos III, Universidad de Granada, Universidad de Sevilla, Generalitat de Catalunya, Gilead Sciences, Associazione Italiana per la Ricerca sul Cancro, Fundación Científica Asociación Española Contra el Cáncer, García-Martín, Paloma, Moñiz Díez, Ana, Sánchez Maldonado, José Manuel, Cabrera Serrano, Antonio José, Horst, Rob ter, Benavente, Yolanda, Landi, Stefano, Macauda, Angelica, Clay-Gilmour, Alyssa, Hernandez-Mohedo, Francisca, Niazi, Yasmeen, González-Sierra, Pedro, Espinet, Blanca, Rodríguez-Sevilla, Juan José, Maffei, Rossana, Blanco, Gonzalo, Giaccherini, Matteo, Puiggros, Anna, Cerhan, James, Marasca, Roberto, Cañadas-Garre, Marisa, López-Nevot, Miguel Ángel, Chen-Liang, Tzu, Thomsen, Hauke, Gámez, Irene, Moreno, Víctor, Marcos-Gragera, Rafael, García-Alvarez, María, Llorca, Javier, Jerez, Andrés, Berndt, Sonja, Butrym, Aleksandra, Norman, Aaron D., Casabonne, Delphine, Luppi, Mario, Slager, Susan L., Hemminki, Kari, Li, Yang, Alcoceba, Miguel, Campa, Daniele, Canzian, Federico, Sanjosé, Silvia de, Försti, Asta, Netea, Mihai, Jurado, Manuel, and Sainz, Juan

Abstract

During the past years, considerable efforts have been made to uncover the genetic component of chronic lymphocytic leukemia (CLL) susceptibility. To date, several genome-wide association studies (GWAS) and their meta-analysis have identified not only single-nucleotide polymorphisms (SNPs) associated with CLL risk [1] but also patient survival [2]. However, despite these noticeable results, it becomes evident that both validation and functional characterization of the genetic variations identified are still required before they can be used in a clinical setting. Hence, we decided to validate the association of 41 GWAS-identified hits for CLL in 1158 CLL cases and 1947 controls ascertained through the Consortium for Research in Chronic lymphocytIc Leukemia (CRuCIAL) and to investigate their impact on modulating host immune responses and their utility to predict disease onset. Study participants were of European ancestry and gave their written informed consent to participate in the study, which was approved by the ethical review committee of participant institutions. CLL patients had often Binet stage A and Rai stage I (67.00% and 79.83%) and, compared to controls, had a higher mean age (66.19 ± 12.66 vs. 55.60 ± 11.50) and an increased male/female ratio (1.54 vs. 0.91). SNPs selection was based on published GWAS, functionality according to HaploReg data, and linkage disequilibrium between the SNPs. Genotyping of genetic variants was performed using KASPTM and Taqman® assays. Hardy–Weinberg equilibrium was assessed in the controls (P > 0.001) and the association between CLL and SNPs was tested using a multivariate unconditional logistic regression analysis adjusted for age, sex, and country of origin. A meta-analysis of the CRuCIAL results with those from previous GWAS was conducted to validate genetic associations and the I [2] statistic was used to assess statistical heterogeneity between the studies (PHet > 0.01). The pooled OR was computed using the fixed-effect mo

Published
2022

38. B-Cell NHL Subtype Risk Associated with Autoimmune Conditions and PRS

Author

Wang, Sophia S., Vajdic, Claire M., Linet, Martha S., Slager, Susan L., Voutsinas, Jenna, Nieters, Alexandra, Casabonne, Delphine, Cerhan, James R., Cozen, Wendy, Alarcón, Graciela, Martínez-Maza, Otoniel, Brown, Elizabeth E., Bracci, Paige M., Turner, Jennifer, Hjalgrim, Henrik, Bhatti, Parveen, Zhang, Yawei, Birmann, Brenda M., Flowers, Christopher R., Paltiel, Ora, Holly, Elizabeth A., Kane, Eleanor, Weisenburger, Dennis D., Maynadié, Marc, Cocco, Pierluigi, Foretova, Lenka, Breen, Elizabeth Crabb, Lan, Qing, Brooks-Wilson, Angela, De Roos, Anneclaire J., Smith, Martyn T., Roman, Eve, Boffetta, Paolo, Kricker, Anne, Zheng, Tongzhang, Skibola, Christine F., Clavel, Jacqueline, Monnereau, Alain, Chanock, Stephen J., Rothman, Nathaniel, Benavente, Yolanda, Hartge, Patricia, Smedby, Karin E., Wang, Sophia S., Vajdic, Claire M., Linet, Martha S., Slager, Susan L., Voutsinas, Jenna, Nieters, Alexandra, Casabonne, Delphine, Cerhan, James R., Cozen, Wendy, Alarcón, Graciela, Martínez-Maza, Otoniel, Brown, Elizabeth E., Bracci, Paige M., Turner, Jennifer, Hjalgrim, Henrik, Bhatti, Parveen, Zhang, Yawei, Birmann, Brenda M., Flowers, Christopher R., Paltiel, Ora, Holly, Elizabeth A., Kane, Eleanor, Weisenburger, Dennis D., Maynadié, Marc, Cocco, Pierluigi, Foretova, Lenka, Breen, Elizabeth Crabb, Lan, Qing, Brooks-Wilson, Angela, De Roos, Anneclaire J., Smith, Martyn T., Roman, Eve, Boffetta, Paolo, Kricker, Anne, Zheng, Tongzhang, Skibola, Christine F., Clavel, Jacqueline, Monnereau, Alain, Chanock, Stephen J., Rothman, Nathaniel, Benavente, Yolanda, Hartge, Patricia, and Smedby, Karin E.

Abstract

Background: A previous International Lymphoma Epidemiology (InterLymph) Consortium evaluation of joint associations between five immune gene variants and autoimmune conditions reported interactions between B-cell response-mediated autoimmune conditions and the rs1800629 genotype on risk of B-cell non–Hodgkin lymphoma (NHL) subtypes. Here, we extend that evaluation using NHL subtype-specific polygenic risk scores (PRS) constructed from loci identified in genome-wide association studies of three common B-cell NHL subtypes. Methods: In a pooled analysis of NHL cases and controls of Caucasian descent from 14 participating InterLymph studies, we evaluated joint associations between B-cell–mediated autoimmune conditions and tertile (T) of PRS for risk of diffuse large B-cell lymphoma (DLBCL; n ¼ 1,914), follicular lymphoma (n ¼ 1,733), and marginal zone lymphoma (MZL; n ¼ 407), using unconditional logistic regression. Results: We demonstrated a positive association of DLBCL PRS with DLBCL risk [T2 vs. T1: OR ¼ 1.24; 95% confidence interval (CI), 1.08–1.43; T3 vs. T1: OR ¼ 1.81; 95% CI, 1.59–2.07; P-trend (Ptrend) < 0.0001]. DLBCL risk also increased with increasing PRS tertile among those with an autoimmune condition, being highest for those with a B-cell–mediated autoimmune condition and a T3 PRS [OR ¼ 6.46 vs. no autoimmune condition and a T1 PRS, Ptrend < 0.0001, P-interaction (Pinteraction) ¼ 0.49]. Follicular lymphoma and MZL risk demonstrated no evidence of joint associations or significant Pinteraction. Conclusions: Our results suggest that PRS constructed from currently known subtype-specific loci may not necessarily capture biological pathways shared with autoimmune conditions. Impact: Targeted genetic (PRS) screening among population subsets with autoimmune conditions may offer opportunities for identifying those at highest risk for (and early detection from) DLBCL.

Published
2022

39. Prediagnostic circulating concentrations of plasma insulin‐like growth factor‐I and risk of lymphoma in the European Prospective Investigation into Cancer and Nutrition

Author

PerezCornago, Aurora, Appleby, Paul N., Tipper, Sarah, Key, Timothy J., Allen, Naomi E., Nieters, Alexandra, Vermeulen, Roel, Roulland, Sandrine, Casabonne, Delphine, Kaaks, Rudolf, Fortner, Renee T., Boeing, Heiner, Trichopoulou, Antonia, La Vecchia, Carlo, Klinaki, Eleni, Hansen, Louise, Tjønneland, Anne, Bonnet, Fabrice, Fagherazzi, Guy, BoutronRuault, MarieChristine, Pala, Valeria, Masala, Giovanna, Sacerdote, Carlotta, Peeters, Petra H., BuenodeMesquita, H. B(as), Weiderpass, Elisabete, Dorronsoro, Miren, Quirós, J. Ramón, Barricarte, Aurelio, Gavrila, Diana, Agudo, Antonio, Borgquist, Signe, Rosendahl, Ann H., Melin, Beatrice, Wareham, Nick, Khaw, KayTee, Gunter, Marc, Riboli, Elio, Vineis, Paolo, and Travis, Ruth C.

Published
2017
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41. COVID-19 among workers of a comprehensive cancer centre between first and second epidemic waves (2020): a seroprevalence study in Catalonia, Spain

Author

Peremiquel-Trillas, Paula, primary, Saura-Lázaro, Anna, additional, Benavente-Moreno, Yolanda, additional, Casabonne, Delphine, additional, Loureiro, Eva, additional, Cabrera, Sandra, additional, Duran, Angela, additional, Garrote, Lidia, additional, Brao, Immaculada, additional, Trelis, Jordi, additional, Galán, Maica, additional, Soler, Francesc, additional, Julià, Joaquim, additional, Cortasa, Dolça, additional, Domínguez, Maria Ángeles, additional, Albasanz-Puig, Adaia, additional, Gudiol, Carlota, additional, Ramírez-Tarruella, Dolors, additional, Muniesa, Joan, additional, Rivas, Juan Pedro, additional, Muñoz-Montplet, Carles, additional, Sedano, Ana, additional, Plans, Àngel, additional, Calvo-Cerrada, Beatriz, additional, Calle, Candela, additional, Clopés, Ana, additional, Carnicer-Pont, Dolors, additional, Alemany, Laia, additional, and Fernández, Esteve, additional

Published
2022
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44. B-Cell NHL Subtype Risk Associated with Autoimmune Conditions and PRS

Author

Wang, Sophia S., primary, Vajdic, Claire M., additional, Linet, Martha S., additional, Slager, Susan L., additional, Voutsinas, Jenna, additional, Nieters, Alexandra, additional, Casabonne, Delphine, additional, Cerhan, James R., additional, Cozen, Wendy, additional, Alarcón, Graciela, additional, Martínez-Maza, Otoniel, additional, Brown, Elizabeth E., additional, Bracci, Paige M., additional, Turner, Jennifer, additional, Hjalgrim, Henrik, additional, Bhatti, Parveen, additional, Zhang, Yawei, additional, Birmann, Brenda M., additional, Flowers, Christopher R., additional, Paltiel, Ora, additional, Holly, Elizabeth A., additional, Kane, Eleanor, additional, Weisenburger, Dennis D., additional, Maynadié, Marc, additional, Cocco, Pierluigi, additional, Foretova, Lenka, additional, Breen, Elizabeth Crabb, additional, Lan, Qing, additional, Brooks-Wilson, Angela, additional, De Roos, Anneclaire J., additional, Smith, Martyn T., additional, Roman, Eve, additional, Boffetta, Paolo, additional, Kricker, Anne, additional, Zheng, Tongzhang, additional, Skibola, Christine F., additional, Clavel, Jacqueline, additional, Monnereau, Alain, additional, Chanock, Stephen J., additional, Rothman, Nathaniel, additional, Benavente, Yolanda, additional, Hartge, Patricia, additional, and Smedby, Karin E., additional

Published
2022
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45. BK virus and cancer in Uganda

Author

Newton, Robert, Ribeiro, Tatiana, Alvarez, Eva, Ziegler, John, Casabonne, Delphine, Carpenter, Lucy, Beral, Valerie, Mbidde, Edward, Parkin, Donald Maxwell, Wabinga, Henry, Mbulaiteye, Sam, Jaffe, Harold, Touzé, Antoine, Coursaget, Pierre, and Kaposi, Uganda

Published
2006

46. Association between anthropometry and lifestyle factors and risk of B-cell lymphoma

Author

Saberi Hosnijeh, Fatemeh, Casabonne, Delphine, Nieters, Alexandra, Solans, Marta, Naudin, Sabine, Ferrari, Pietro, Mckay, James D., Benavente, Yolanda, Weiderpass, Elisabete, Freisling, Heinz, Severi, Gianluca, Boutron Ruault, Marie-Christine, Besson, Caroline, Agnoli, Claudia, Masala, Giovanna, Sacerdote, Carlotta, Tumino, Rosario, Huerta, Jose Maria, Amiano, Pilar, Rodriguez-Barranco, Miguel, Bonet, Catalina, Barricarte, Aurelio, Christakoudi, Sofia, Knuppel, Anika, Bueno-de-Mesquita, Bas, Schulze, Matthias B. (Prof. Dr.), Kaaks, Rudolf, Canzian, Federico, Spath, Florentin, Jerkeman, Mats, Rylander, Charlotta, Tjonneland, Anne, Olsen, Anja, Borch, Kristin Benjaminsen, and Vermeulen, Roel

Subjects
Institut für Ernährungswissenschaft, ddc:500
Abstract

To better understand the role of individual and lifestyle factors in human disease, an exposome-wide association study was performed to investigate within a single-study anthropometry measures and lifestyle factors previously associated with B-cell lymphoma (BCL). Within the European Prospective Investigation into Cancer and nutrition study, 2402 incident BCL cases were diagnosed from 475 426 participants that were followed-up on average 14 years. Standard and penalized Cox regression models as well as principal component analysis (PCA) were used to evaluate 84 exposures in relation to BCL risk. Standard and penalized Cox regression models showed a positive association between anthropometric measures and BCL and multiple myeloma/plasma cell neoplasm (MM). The penalized Cox models additionally showed the association between several exposures from categories of physical activity, smoking status, medical history, socioeconomic position, diet and BCL and/or the subtypes. PCAs confirmed the individual associations but also showed additional observations. The PC5 including anthropometry, was positively associated with BCL, diffuse large B-cell lymphoma (DLBCL) and MM. There was a significant positive association between consumption of sugar and confectionary (PC11) and follicular lymphoma risk, and an inverse association between fish and shellfish and Vitamin D (PC15) and DLBCL risk. The PC1 including features of the Mediterranean diet and diet with lower inflammatory score showed an inverse association with BCL risk, while the PC7, including dairy, was positively associated with BCL and DLBCL risk. Physical activity (PC10) was positively associated with DLBCL risk among women. This study provided informative insights on the etiology of BCL.

Published
2021

48. Physical activity and the risk of non‐Hodgkin lymphoma subtypes: A pooled analysis.

Author

Boyle, Terry, Kleinstern, Geffen, Bracci, Paige M., Cerhan, James R., Benavente, Yolanda, Casabonne, Delphine, Chiu, Brian C.‐H., Habermann, Thomas M., Holly, Elizabeth A., Liebow, Mark, Norman, Aaron, Paltiel, Ora, Robinson, Dennis, Rothman, Nathaniel, Abu Seir, Rania, Slager, Susan L., Villeneuve, Paul J., Wang, Sophia S., Weisenburger, Dennis D., and Spinelli, John J.

Subjects
NON-Hodgkin's lymphoma, PHYSICAL activity, T-cell lymphoma, MUCOSA-associated lymphoid tissue lymphoma, FOLLICULAR lymphoma, DIFFUSE large B-cell lymphomas, CHRONIC leukemia
Abstract

Non‐Hodgkin lymphoma (NHL) is composed of a heterogeneous collection of subtypes with considerable differences in genetics, biology and aetiology. Studies to date on physical activity and NHL risk have not had sufficient sample size to evaluate whether associations differ by subtype. We pooled data from nine case‐control studies to examine the association between moderate‐to‐vigorous intensity physical activity (MVPA) and risk of NHL overall and by subtype (diffuse large B‐cell lymphoma, follicular lymphoma, chronic lymphocytic leukaemia/small lymphocytic lymphoma, marginal zone lymphoma and mature T‐cell lymphoma). A total of 5653 cases and 9115 controls were included in the pooled analysis. Physical activity was harmonised across nine studies and modelled as study‐specific tertiles. Multinomial logistic regression was used to estimate the association between physical activity and NHL, adjusting for confounders. The overall odds of NHL was 13% lower among participants in the most active tertile of MVPA compared to the least active tertile (adjusted odds ratio = 0.87, 95% CI = 0.80, 0.95). Similar decreases were observed across NHL subtypes. In summary, in this pooled analysis of case‐control studies, physical activity was associated with a modest risk reduction for each NHL subtype examined and with overall NHL. [ABSTRACT FROM AUTHOR]

Published
2023
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50. Consumption of Ultra-Processed Food and Drinks and Chronic Lymphocytic Leukemia in the MCC-Spain Study

Author

Solans, Marta, Fernández-Barrés, Sílvia, Romaguera, Dora, Benavente, Yolanda, Marcos-Gragera, Rafael, Gracia-Lavedan, Esther, Costas, Laura, Robles, Claudia, Gonzalez-Barca, Eva, Banda, Esmeralda de la, Alonso, Esther, Aymerich, Marta, Campo, Elias, Llorca, Javier, Fernández-Tardon, Guillermo, Olmedo-Requena, Rocío, Gimeno, Eva, Castaño-Vinyals, Gemma, Aragonés, Núria, Kogevinas, M, Pollán, Marina, Sanjose, Sílvia de, Amiano, Pilar, Casabonne, Delphine, Universitat Autònoma de Barcelona, Ministerio de Economía y Competitividad (España), Instituto de Salud Carlos III, Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF), Centro de Investigación Biomédica en Red - CIBERESP (Epidemiología y Salud Pública), Agency for Administration of University and Research, Institució Catalana de Recerca i Estudis Avançats, UAM. Departamento de Medicina Preventiva y Salud Pública, and Universidad de Cantabria

Subjects
Food Handling, Health, Toxicology and Mutagenesis, Chronic lymphocytic leukemia, Logistic regression, 0302 clinical medicine, hemic and lymphatic diseases, Medicine, 030212 general & internal medicine, Prospective Studies, Càncer, Cancer, education.field_of_study, Confounding, Case-control study, Leukemia, 030220 oncology & carcinogenesis, Adult, medicine.medical_specialty, Estils de vida, Medicina, Population, Lifestyles, Article, 03 medical and health sciences, Casecontrol study, Leucèmia limfocítica crònica -- Etiologia, Internal medicine, Ultra-processed foods, Humans, Chronic lymphocytic leukemia -- Etiology, Leucèmia limfocítica crònica, education, business.industry, Public Health, Environmental and Occupational Health, Odds ratio, medicine.disease, Leukemia, Lymphocytic, Chronic, B-Cell, NOVA classification, Ultra-processed food, Diet, Spain, Case-Control Studies, Etiology, Fast Foods, business
Abstract

Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults in Western countries. Its etiology is largely unknown but increasing incidence rates observed worldwide suggest that lifestyle and environmental factors such as diet might play a role in the development of CLL. Hence, we hypothesized that the consumption of ultra-processed food and drinks (UPF) might be associated with CLL. Data from a Spanish population-based case-control study (MCC-Spain study) including 230 CLL cases (recruited within three years of diagnosis) and 1634 population-based controls were used. The usual diet during the previous year was collected through a validated food frequency questionnaire and food and drink consumption was categorized using the NOVA classification scheme. Logistic regression models adjusted for potential confounders were used. Overall, no association was reported between the consumption of UPF and CLL cases (OR per each 10% increase of the relative contribution of UPF to total dietary intake = 1.09 (95% CI: 0.94; 1.25)), independently of the Rai stage at diagnosis. However, when analyses were restricted to cases diagnosed within, Spanish Ministry of Economy and Competitiveness Carlos III Institute of Health, FEDER funds/European Regional Development Fund (ERDF) (grants PI17/01280, PI11/01810, PI14/01219, PI11/02213, PI09/1662, PI15/00966, PI18/00909, RCESP C03/09, RTICESP C03/10, RTIC RD06/0020/0095, RD12/0036/0056, Rio Hortega CM13/00232, Juan de la Cierva de Incorporacion IJCI-2016-29502 and SV-09-CLINIC-1), Centro de Investigación Biomédica en Red: Epidemiología y Salud Pública (CIBERESP, Spain), Agència de Gestió d’Ajuts Universitaris i de Recerca (AGAUR), CERCA Programme/Generalitat de Catalunya for institutional support(2017SGR1085), European Regional Development FundERDF/FEDER, Spanish Ministerio de Economía y Competitividad (MINECO), ISCIII-Sub-Directorate General for Evaluation and the European Regional Development Fund (FEDER-”Una manera de Hacer Europa”) and CIBERONC., Spanish Ministry of Science and Innovation through the “Centro de Excelencia Severo Ochoa 2019–2023” Program (CEX2018-000806-S), Generalitat de Catalunya - CERCA Program

Published
2021

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