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37 results on '"Casalena, Alfonsina"'

1. Long-Term Treatment Over 52 Weeks with Monthly Fremanezumab in Drug-Resistant Migraine: A Prospective Multicenter Cohort Study

Author

Caponnetto, Valeria, Russo, Antonio, Silvestro, Marcello, Tessitore, Alessandro, De Icco, Roberto, Vaghi, Gloria, Sances, Grazia, Tassorelli, Cristina, Baraldi, Carlo, Castro, Flavia Lo, Guerzoni, Simona, Prudenzano, Maria Pia, Fallacara, Adriana, Gentile, Martino, Ornello, Raffaele, Onofri, Agnese, Burgalassi, Andrea, Chiarugi, Alberto, De Cesaris, Francesco, Granato, Antonio, Casalena, Alfonsina, De Tommaso, Marina, Mampreso, Edoardo, Merlo, Paola, Coppola, Gianluca, Battistini, Stefania, Rebecchi, Valentina, Rainero, Innocenzo, Sepe, Federica Nicoletta, Dalla Volta, Giorgio, Sacco, Simona, Geppetti, Pierangelo, and Iannone, Luigi Francesco

Published
2023
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2. Validation of the Italian version of the Cluster Headache Impact Questionnaire (CHIQ)

Author

Onofri, Agnese, Iannone, Luigi Francesco, Granato, Antonio, Garascia, Gabriele, Bartole, Luca, Manganotti, Paolo, Vollono, Catello, Romozzi, Marina, Sottani, Costanza, Calabresi, Paolo, Tassorelli, Cristina, Sances, Grazia, Allena, Marta, De Icco, Roberto, De Cesaris, Francesco, Burgalassi, Andrea, Chiarugi, Alberto, Baraldi, Carlo, Guerzoni, Simona, Prudenzano, Maria Pia, Fallacara, Adriana, Albanese, Maria, Rainero, Innocenzo, Coppola, Gianluca, Casalena, Alfonsina, Mampreso, Edoardo, Pistoia, Francesca, Sarchielli, Paola, Morson, Marisa, Sacco, Simona, Geppetti, Pierangelo, and Ornello, Raffaele

Published
2023
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3. Stroke with large vessel occlusion in the posterior circulation: IV thrombolysis plus thrombectomy versus IV thrombolysis alone

Author

Cappellari, Manuel, Saia, Valentina, Pracucci, Giovanni, Casetta, Ilaria, Fainardi, Enrico, Sallustio, Fabrizio, Ruggiero, Maria, Romoli, Michele, Simonetti, Luigi, Zini, Andrea, Lazzarotti, Guido Andrea, Orlandi, Giovanni, Vallone, Stefano, Bigliardi, Guido, Renieri, Leonardo, Nencini, Patrizia, Semeraro, Vittorio, Boero, Giovanni, Bracco, Sandra, Tassi, Rossana, Castellano, Davide, Naldi, Andrea, Biraschi, Francesco, Nicolini, Ettore, Del Sette, Bruno, Malfatto, Laura, Allegretti, Luca, Tassinari, Tiziana, Tessitore, Agostino, Ferraù, Ludovica, Saletti, Andrea, De Vito, Alessandro, Lafe, Elvis, Cavallini, Anna, Bergui, Mauro, Bosco, Giovanni, Feraco, Paola, Bignamini, Valeria, Mandruzzato, Nicolò, Vit, Federica, Mardighian, Dikran, Magoni, Mauro, Comelli, Simone, Melis, Maurizio, Menozzi, Roberto, Scoditti, Umberto, Cester, Giacomo, Viario, Federica, Stecco, Alessandro, Fleetwood, Thomas, Filauri, Pietro, Sacco, Simona, Giorgianni, Andrea, Cariddi, Lucia Princiotta, Piano, Mariangela, Motto, Cristina, Gallesio, Ivan, Sepe, Federica, Romano, Giuseppe, Grasso, Maria Federica, Lozupone, Emilio, Fasano, Antonio, Comai, Alessio, Franchini, Erica, Bruni, Stefano, Silvestrini, Mauro, Chiumarulo, Luigi, Petruzzelli, Marco, Pavia, Marco, Invernizzi, Paolo, Puglielli, Edoardo, Casalena, Alfonsina, Pedicelli, Alessandro, Frisullo, Giovanni, Amistà, Pietro, Russo, Monia, Allegritti, Massimiliano, Caproni, Stefano, Mangiafico, Salvatore, and Toni, Danilo

Published
2023
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4. Carotid artery stenting during endovascular thrombectomy for acute ischemic stroke with tandem occlusion: the Italian Registry of Endovascular Treatment in Acute Stroke

Author

Sallustio, Fabrizio, Pracucci, Giovanni, Cappellari, Manuel, Saia, Valentina, Mascolo, Alfredo Paolo, Marrama, Federico, Gandini, Roberto, Koch, Giacomo, Diomedi, Marina, D’Agostino, Federica, Rocco, Alessandro, Da Ros, Valerio, Wlderk, Andrea, Nezzo, Marco, Argirò, Renato, Morosetti, Daniele, Renieri, Leonardo, Nencini, Patrizia, Vallone, Stefano, Zini, Andrea, Bigliardi, Guido, Pitrone, Antonio, Grillo, Francesco, Bracco, Sandra, Tassi, Rossana, Bergui, Mauro, Naldi, Andrea, Carità, Giuseppe, Casetta, Ilaria, Gasparotti, Roberto, Magoni, Mauro, Simonetti, Luigi, Haznedari, Nicolò, Paolucci, Matteo, Mavilio, Nicola, Malfatto, Laura, Menozzi, Roberto, Genovese, Antonio, Cosottini, Mirco, Orlandi, Giovanni, Comai, Alessio, Franchini, Enrica, Pedicelli, Alessandro, Frisullo, Giovanni, Puglielli, Edoardo, Casalena, Alfonsina, Cester, Giacomo, Baracchini, Claudio, Castellano, Davide, Di Liberto, Alessandra, Ricciardi, Giuseppe Kenneth, Chiumarulo, Luigi, Petruzzellis, Marco, Lafe, Elvis, Persico, Alessandra, Cavasin, Nicola, Critelli, Adriana, Semeraro, Vittorio, Tinelli, Angelica, Giorgianni, Andrea, Carimati, Federico, Auteri, William, Rizzuto, Stefano, Biraschi, Francesco, Nicolini, Ettore, Ferrari, Antonio, Melis, Maurizio, Calia, Stefano, Tassinari, Tiziana, Nuzzi, Nunzio Paolo, Corato, Manuel, Sacco, Simona, Squassina, Guido, Invernizzi, Paolo, Gallesio, Ivan, Ruiz, Luigi, Dui, Giovanni, Carboni, Nicola, Amistà, Pietro, Russo, Monia, Maiore, Mario, Zanda, Bastianina, Craparo, Giuseppe, Mannino, Marina, Inzitari, Domenico, Toni, Danilo, and Mangiafico, Salvatore

Published
2023
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5. Association of the careggi collateral score with radiological outcomes after thrombectomy for stroke with an occlusion of the middle cerebral artery

Author

Cappellari, Manuel, Saia, Valentina, Pracucci, Giovanni, Fainardi, Enrico, Nencini, Patrizia, Malfatto, Laura, Tassi, Rossana, Cerrato, Paolo, Mancuso, Michelangelo, Pesare, Angela, La Spina, Paolino, Lotti, Enrico Maria, Casalena, Alfonsina, Petruzzellis, Marco, Baracchini, Claudio, Via, Alessandra Giai, Gaudiano, Carmen, Sallustio, Fabrizio, Tassinari, Tiziana, Critelli, Adriana, Melis, Maurizio, Persico, Alessandra, Casetta, Ilaria, Sacco, Simona, Ferrandi, Delfina, Marcheselli, Simona, Russo, Monia, Zivelonghi, Cecilia, Mandruzzato, Nicolò, Invernizzi, Paolo, Romano, Daniele, Nicolini, Ettore, Scoditti, Umberto, Magoni, Mauro, Cariddi, Lucia Princiotta, Vallone, Stefano, Inzitari, Domenico, Toni, Danilo, and Mangiafico, Salavatore

Published
2022
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6. The Comorbidities Coma Scale (CoCoS): Psychometric Properties and Clinical Usefulness in Patients With Disorders of Consciousness.

Author

Pistoia, Francesca, Carolei, Antonio, Bodien, Yelena G, Greenfield, Sheldon, Kaplan, Sherrie, Sacco, Simona, Pistarini, Caterina, Casalena, Alfonsina, De Tanti, Antonio, Cazzulani, Benedetta, Bellaviti, Gianluca, Sarà, Marco, and Giacino, Joseph

Subjects
coma, comorbidities, minimally conscious state, unresponsive wakefulness syndrome, vegetative state, Clinical Sciences, Neurosciences, Psychology
Abstract

Although comorbidities have a well-known impact on the functional recovery of patients with disorders of consciousness, including coma, vegetative state (VS), and minimally conscious state (MCS), a specific tool for their assessment in this challenging group of patients is lacking. For this aim, a multistep process was used to develop and validate the Comorbidities Coma Scale (CoCoS) in a sample of 162 patients with a diagnosis of coma, VS or MCS admitted to four Acute Inpatient Rehabilitation Units. To establish the psychometric properties of the scale, content validity, and internal consistency were investigated through Exploratory Factor Analysis in the whole sample (n = 162). Interrater reliability, assessed by the weighted Cohen's kappa (Kw), and concurrent validity of the scale as compared to the Greenfield Scale, assessed by ρ Spearman's correlation coefficient, were investigated in a subsample of patients (n = 52) within two of the above units. Our findings provided evidence of a good content validity of the scale, with the identification of a 12-factor structure representing the different comorbid dimensions of the target population. Inter-rater reliability was excellent in both the rehabilitation units where the assessment was made [Kw 0.98 (95% CI 0.96-0.99)]. CoCoS total scores correlated significantly with total scores of the Greenfield Scale (ρ = 0.932, 95% CI 0.89-0.96; P < 0.0001) indicating that CoCoS has concurrent validity while being more informative about the specific pattern of comorbidities of these challenging patients. The CoCos is a new tool which standardizes the approach to assessment of comorbid conditions and reliably identifies the category and severity of each comorbidity detected. It may be used for both clinical and research applications.

Published
2019

7. Comparing the relative and absolute effect of erenumab: is a 50% response enough? Results from the ESTEEMen study

Author

Ornello, Raffaele, Baraldi, Carlo, Guerzoni, Simona, Lambru, Giorgio, Andreou, Anna P., Raffaelli, Bianca, Gendolla, Astrid, Barbanti, Piero, Aurilia, Cinzia, Egeo, Gabriella, Cevoli, Sabina, Favoni, Valentina, Vernieri, Fabrizio, Altamura, Claudia, Russo, Antonio, Silvestro, Marcello, Valle, Elisabetta Dalla, Mancioli, Andrea, Ranieri, Angelo, Alfieri, Gennaro, Latysheva, Nina, Filatova, Elena, Talbot, Jamie, Cheng, Shuli, Holle, Dagny, Scheffler, Armin, Nežádal, Tomáš, Čtrnáctá, Dana, Šípková, Jitka, Matoušová, Zuzana, Casalena, Alfonsina, Maddestra, Maurizio, Viola, Stefano, Affaitati, Giannapia, Giamberardino, Maria Adele, Pistoia, Francesca, Reuter, Uwe, and Sacco, Simona

Published
2022
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9. Association of anti‐calcitonin gene‐related peptide with other monoclonal antibodies for different diseases: A multicenter, prospective, cohort study.

Author

Iannone, Luigi Francesco, Romozzi, Marina, Russo, Antonio, Saporito, Gennaro, De Santis, Federico, Ornello, Raffaele, Sances, Grazia, Vaghi, Gloria, Tassorelli, Cristina, Albanese, Maria, Guerzoni, Simona, Casalena, Alfonsina, Vollono, Catello, Calabresi, Paolo, Prudenzano, Maria Pia, Mampreso, Edoardo, Volta, Giorgio Dalla, Valente, Maria Rosaria, Avino, Gianluca, and Chiarugi, Alberto

Abstract

Background and purpose: Although there is extensive evidence about the safety of monoclonal antibodies against calcitonin gene‐related peptide (anti‐CGRP mAbs) in combination with traditional drugs, scarce data are available on the safety of their combination with other mAbs. This study aimed to evaluate the 6‐month effectiveness and tolerability of anti‐CGRP mAbs in combination with other mAbs for different diseases. Methods: Patients included in the Italian Headache Registry and treated concomitantly with an anti‐CGRP mAb and another mAb were included. Effectiveness outcomes for migraine included reduction from baseline of monthly headache days (MHDs), Migraine Disability Assessment (MIDAS) score, Headache Impact Test‐6 (HIT‐6) scores, and Patients' Global Impression of Change (PGIC) scale. Adverse events (AEs) were recorded. Results: Thirty‐eight patients were included. In 27 patients (71.1%), the anti‐CGRP mAb was added to a previously ongoing mAb. Nine patients (23.7%) discontinued one of the two mAbs before the end of treatment (seven discontinued the anti‐CGRP mAb and two the other mAb). One patient discontinued for AEs. Anti‐CGRP mAbs were discontinued due to ineffectiveness (n = 5, 55.5%) and one each (11.1%) for clinical remission and lost to follow‐up. MHDs significantly decreased from baseline to 3 months (p < 0.0001) and 6 months (p < 0.001), as did the MIDAS and the HIT‐6 scores at 3 and 6 months (p < 0.001). For anti‐CGRP mAbs, 27.4% of patients reported PGIC ≥ 5 at 3 months and 48.3% at 6 months. Mild AEs associated with introduction of a second mAb were detected in six patients (15.8%). Conclusions: In this real‐world study, anti‐CGRP mAbs showed safety and effectiveness when administered concomitantly with other mAbs. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Direct thrombectomy for stroke in the presence of absolute exclusion criteria for thrombolysis

Author

Cappellari, Manuel, Pracucci, Giovanni, Forlivesi, Stefano, Saia, Valentina, Limbucci, Nicola, Nencini, Patrizia, Inzitari, Domenico, Da Ros, Valerio, Sallustio, Fabrizio, Vallone, Stefano, Bigliardi, Guido, Zini, Andrea, Vinci, Sergio Lucio, Dell’Aera, Cristina, Bracco, Sandra, Cioni, Samuele, Tassi, Rossana, Bergui, Mauro, Naldi, Andrea, Carità, Giuseppe, Azzini, Cristiano, Casetta, Ilaria, Gasparotti, Roberto, Magoni, Mauro, Castellan, Lucio, Finocchi, Cinzia, Menozzi, Roberto, Scoditti, Umberto, Causin, Francesco, Viaro, Federica, Puglielli, Edoardo, Casalena, Alfonsina, Ruggiero, Maria, Biguzzi, Sara, Castellano, Davide, Cavallo, Roberto, Lazzarotti, Guido Andrea, Orlandi, Giovanni, Sgreccia, Alessandro, Denaro, Maria Federica, Cavasin, Nicola, Critelli, Adriana, Ciceri, Elisa Francesca Maria, Bonetti, Bruno, Chiumarulo, Luigi, Petruzzelli, Marco, Pellegrino, Carlo, Carimati, Federico, Burdi, Nicola, Prontera, Maria Pia, Auteri, Wiliam, Petrone, Alfredo, Guidetti, Giulio, Nicolini, Ettore, Ganci, Giuseppe, Sugo, Annalisa, Filauri, Pietro, Sacco, Simona, Squassina, Guido, Invernizzi, Paolo, Nuzzi, Nunzio Paolo, Corato, Manuel, Amistà, Pietro, Gentile, Mauro, Barbero, Stefano, Schirru, Federica, Craparo, Giuseppe, Mannino, Marina, Simonetti, Luigi, Mangiafico, Salvatore, and Toni, Danilo

Published
2020
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12. Endovascular Thrombectomy for Acute Ischemic Stroke Beyond 6 Hours From Onset: A Real-World Experience

Author

Casetta, Ilaria, Fainardi, Enrico, Saia, Valentina, Pracucci, Giovanni, Padroni, Marina, Renieri, Leonardo, Nencini, Patrizia, Inzitari, Domenico, Morosetti, Daniele, Sallustio, Fabrizio, Vallone, Stefano, Bigliardi, Guido, Zini, Andrea, Longo, Marcello, Francalanza, Isabella, Bracco, Sandra, Vallone, Ignazio M., Tassi, Rossana, Bergui, Mauro, Naldi, Andrea, Saletti, Andrea, De Vito, Alessandro, Gasparotti, Roberto, Magoni, Mauro, Castellan, Lucio, Serrati, Carlo, Menozzi, Roberto, Scoditti, Umberto, Causin, Francesco, Pieroni, Alessio, Puglielli, Edoardo, Casalena, Alfonsina, Sanna, Antioco, Ruggiero, Maria, Cordici, Francesco, Di Maggio, Luca, Duc, Enrica, Cosottini, Mirco, Giannini, Nicola, Sanfilippo, Giuseppina, Zappoli, Federico, Cavallini, Anna, Cavasin, Nicola, Critelli, Adriana, Ciceri, Elisa, Plebani, Mauro, Cappellari, Manuel, Chiumarulo, Luigi, Petruzzellis, Marco, Terrana, Alberto, Cariddi, Lucia Princiotta, Burdi, Nicola, Tinelli, Angelica, Auteri, William, Silvagni, Umberto, Biraschi, Francesco, Nicolini, Ettore, Padolecchia, Riccardo, Tassinari, Tiziana, Filauri, Pietro, Sacco, Simona, Pavia, Marco, Invernizzi, Paolo, Nuzzi, Nunzio P., Marcheselli, Simona, Amistà, Pietro, Russo, Monia, Gallesio, Ivan, Craparo, Giuseppe, Mannino, Marina, Mangiafico, Salvatore, and Toni, Danilo

Published
2020
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15. General Anesthesia Versus Conscious Sedation and Local Anesthesia During Thrombectomy for Acute Ischemic Stroke

Author

Cappellari, Manuel, Pracucci, Giovanni, Forlivesi, Stefano, Saia, Valentina, Nappini, Sergio, Nencini, Patrizia, Inzitari, Domenico, Greco, Laura, Sallustio, Fabrizio, Vallone, Stefano, Bigliardi, Guido, Zini, Andrea, Pitrone, Antonio, Grillo, Francesco, Musolino, Rosa, Bracco, Sandra, Tinturini, Rebecca, Tassi, Rossana, Bergui, Mauro, Cerrato, Paolo, Saletti, Andrea, De Vito, Alessandro, Casetta, Ilaria, Gasparotti, Roberto, Magoni, Mauro, Castellan, Lucio, Malfatto, Laura, Menozzi, Roberto, Scoditti, Umberto, Causin, Francesco, Baracchini, Claudio, Puglielli, Edoardo, Casalena, Alfonsina, Ruggiero, Maria, Malatesta, Emanuele, Comelli, Chiara, Chianale, Gigliola, Lauretti, Dario Luca, Mancuso, Michelangelo, Lafe, Elvis, Cavallini, Anna, Cavasin, Nicola, Critelli, Adriana, Ciceri, Elisa Francesca Maria, Bonetti, Bruno, Chiumarulo, Luigi, Petruzzelli, Marco, Giorgianni, Andrea, Versino, Maurizio, Ganimede, Maria Porzia, Tinelli, Angelica, Auteri, Wiliam, Petrone, Alfredo, Guidetti, Giulio, Nicolini, Ettore, Allegretti, Luca, Tassinari, Tiziana, Filauri, Pietro, Sacco, Simona, Pavia, Marco, Invernizzi, Paolo, Nuzzi, Nunzio Paolo, Carmela Spinelli, Maria, Amistà, Pietro, Russo, Monia, Ferrandi, Delfina, Corraine, Simona, Craparo, Giuseppe, Mannino, Marina, Simonetti, Luigi, Toni, Danilo, and Mangiafico, Salvatore

Published
2020
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16. IER-SICH Nomogram to Predict Symptomatic Intracerebral Hemorrhage After Thrombectomy for Stroke

Author

Cappellari, Manuel, Mangiafico, Salvatore, Saia, Valentina, Pracucci, Giovanni, Nappini, Sergio, Nencini, Patrizia, Konda, Daniel, Sallustio, Fabrizio, Vallone, Stefano, Zini, Andrea, Bracco, Sandra, Tassi, Rossana, Bergui, Mauro, Cerrato, Paolo, Pitrone, Antonio, Grillo, Francesco, Saletti, Andrea, De Vito, Alessandro, Gasparotti, Roberto, Magoni, Mauro, Puglielli, Edoardo, Casalena, Alfonsina, Causin, Francesco, Baracchini, Claudio, Castellan, Lucio, Malfatto, Laura, Menozzi, Roberto, Scoditti, Umberto, Comelli, Chiara, Duc, Enrica, Comai, Alessio, Franchini, Enrica, Cosottini, Mirco, Mancuso, Michelangelo, Peschillo, Simone, De Michele, Manuela, Giorgianni, Andrea, Delodovici, Maria Luisa, Lafe, Elvis, Denaro, Maria Federica, Burdi, Nicola, Internò, Saverio, Cavasin, Nicola, Critelli, Adriana, Chiumarulo, Luigi, Petruzzellis, Marco, Doddi, Marco, Carolei, Antonio, Auteri, William, Petrone, Alfredo, Padolecchia, Riccardo, Tassinari, Tiziana, Pavia, Marco, Invernizzi, Paolo, Turcato, Gianni, Forlivesi, Stefano, Ciceri, Elisa Francesca Maria, Bonetti, Bruno, Inzitari, Domenico, and Toni, Danilo

Published
2019
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17. Cranial autonomic symptoms and response to monoclonal antibodies targeting the Calcitonin gene-related peptide pathway: A real-world study

Author

De Matteis, Eleonora, primary, Caponnetto, Valeria, additional, Casalena, Alfonsina, additional, Frattale, Ilaria, additional, Gabriele, Amleto, additional, Affaitati, Giannapia, additional, Giamberardino, Maria Adele, additional, Maddestra, Maurizio, additional, Viola, Stefano, additional, Pistoia, Francesca, additional, Sacco, Simona, additional, and Ornello, Raffaele, additional

Published
2022
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18. Additional file 1 of Comparing the relative and absolute effect of erenumab: is a 50% response enough? Results from the ESTEEMen study

Author

Ornello, Raffaele, Baraldi, Carlo, Guerzoni, Simona, Lambru, Giorgio, Andreou, Anna P., Raffaelli, Bianca, Gendolla, Astrid, Barbanti, Piero, Aurilia, Cinzia, Egeo, Gabriella, Cevoli, Sabina, Favoni, Valentina, Vernieri, Fabrizio, Altamura, Claudia, Russo, Antonio, Silvestro, Marcello, Valle, Elisabetta Dalla, Mancioli, Andrea, Ranieri, Angelo, Alfieri, Gennaro, Latysheva, Nina, Filatova, Elena, Talbot, Jamie, Cheng, Shuli, Holle, Dagny, Scheffler, Armin, Ne����dal, Tom����, ��trn��ct��, Dana, ����pkov��, Jitka, Matou��ov��, Zuzana, Casalena, Alfonsina, Maddestra, Maurizio, Viola, Stefano, Affaitati, Giannapia, Giamberardino, Maria Adele, Pistoia, Francesca, Reuter, Uwe, and Sacco, Simona

Subjects
Data_FILES
Abstract

Additional file 1.

Published
2022
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19. Carotid artery stenting during endovascular thrombectomy for acute ischemic stroke with tandem occlusion: the Italian Registry of Endovascular Treatment in Acute Stroke

Author

Sallustio, Fabrizio, Pracucci, Giovanni, Cappellari, Manuel, Saia, Valentina, Mascolo, Alfredo Paolo, Marrama, Federico, Gandini, Roberto, Koch, Giacomo, Diomedi, Marina, D’Agostino, Federica, Rocco, Alessandro, Da Ros, Valerio, Wlderk, Andrea, Nezzo, Marco, Argirò, Renato, Morosetti, Daniele, Renieri, Leonardo, Nencini, Patrizia, Vallone, Stefano, Zini, Andrea, Bigliardi, Guido, Pitrone, Antonio, Grillo, Francesco, Bracco, Sandra, Tassi, Rossana, Bergui, Mauro, Naldi, Andrea, Carità, Giuseppe, Casetta, Ilaria, Gasparotti, Roberto, Magoni, Mauro, Simonetti, Luigi, Haznedari, Nicolò, Paolucci, Matteo, Mavilio, Nicola, Malfatto, Laura, Menozzi, Roberto, Genovese, Antonio, Cosottini, Mirco, Orlandi, Giovanni, Comai, Alessio, Franchini, Enrica, Pedicelli, Alessandro, Frisullo, Giovanni, Puglielli, Edoardo, Casalena, Alfonsina, Cester, Giacomo, Baracchini, Claudio, Castellano, Davide, Di Liberto, Alessandra, Ricciardi, Giuseppe Kenneth, Chiumarulo, Luigi, Petruzzellis, Marco, Lafe, Elvis, Persico, Alessandra, Cavasin, Nicola, Critelli, Adriana, Semeraro, Vittorio, Tinelli, Angelica, Giorgianni, Andrea, Carimati, Federico, Auteri, William, Rizzuto, Stefano, Biraschi, Francesco, Nicolini, Ettore, Ferrari, Antonio, Melis, Maurizio, Calia, Stefano, Tassinari, Tiziana, Nuzzi, Nunzio Paolo, Corato, Manuel, Sacco, Simona, Squassina, Guido, Invernizzi, Paolo, Gallesio, Ivan, Ruiz, Luigi, Dui, Giovanni, Carboni, Nicola, Amistà, Pietro, Russo, Monia, Maiore, Mario, Zanda, Bastianina, Craparo, Giuseppe, Mannino, Marina, Inzitari, Domenico, Toni, Danilo, Mangiafico, Salvatore, Gasparotti, R., Inzitari, D., Mangiafico, S., Toni, D., Vallone, S., Zini, A., Bergui, M., Causin, F., Ciccone, A., Nencini, P., Saletti, A., Sallustio, F., Tassi, R., Thyrion, F. Zappoli, Pracucci, G., Saia, V., Gandini, R., Da Ros, V., Greco, L., Morosetti, D., Diomedi, M., Nappini, S., Limbucci, N., Renieri, L., Fainardi, E., Verganti, L., Sacchetti, F., Zelent, G., Bigliardi, G., Dell’Acqua, M. L., Picchetto, L., Vandelli, L., Pentore, R., Maffei, S., Nichelli, P., Longo, M., Pitrone, A., Vinci, S. L., Velo, M., Caragliano, A., Tessitore, A., Bonomo, O., Musolino, R., La Spina, P., Casella, C., Fazio, M. C., Grillo, F., Cotroneo, M., Dell’Aera, C., Francalanza, I., Bracco, S., Cioni, S., Gennari, P., Vallone, I. M., Cerase, A., Martini, G., Stura, G., Daniele, D., Cerrato, P., Naldi, A., Onofrio, M., De Vito, A., Azzini, C., Casetta, I., Mardighian, D., Frigerio, M., Magoni, M., Costa, A., Simonetti, L., Cirillo, L., Taglialatela, F., Isceri, S., Princiotta, C., Dall’Olio, M., Cellerini, M., Gentile, M., Piccolo, L., Migliaccio, L., Brancaleoni, L., Naldi, F., Romoli, M., Zaniboni, A., Ruggiero, M., Sanna, A., Haznedari, N., Commodaro, C., Longoni, M., Biguzzi, S., Cordici, F., Malatesta, E., Castellan, L., Mavilio, N., Salsano, G., Malfatto, L., Finocchi, C., Menozzi, R., Piazza, P., Epifani, E., Andreone, A., Scoditti, U., Castellini, P., Latte, L., Grisendi, I., Cosottini, M., Puglioli, M., Lazzarotti, G., Lauretti, D., Mancuso, M., Giannini, N., Maccarone, M., Orlandi, G., Comai, A., Bonatti, G., Nano, G., Ferro, F., Bonatti, M., Dall’Ora, E., Dossi, R. Currò, Turri, E., Turri, M., Colosimo, C., Pedicelli, A., D’Argento, F., Alexandre, A., Frisullo, G., Di Egidio, V., Puglielli, E. G., Ruggero, L., Assetta, M., Casalena, A., Cester, G., Baracchini, C., Viaro, F., Pieroni, A., Vaudano, G., Comelli, C., Di Maggio, L., Castellano, D., Cavallo, R., Duc, E., Chianale, G., Ciceri, E. F. M., Plebani, M., Augelli, R., Zampieri, P., Grazioli, A., Cappellari, M., Forlivesi, S., Tomelleri, G., Micheletti, N., Chiumarulo, L., Zimatore, D. S., Federico, F., Petruzzelli, M., Zappoli, F., Lafe, E., Sanfilippo, G., Sgreccia, A., Martignoni, A., Cavallini, A., Denaro, F., Persico, A., Cagliari, E., Cavasin, N., Quatrale, R., Critelli, A., Burdi, N., Semeraro, V., Lucarelli, N., Ganimede, M. P., Internò, S., Tinelli, A., Prontera, M. P., Pesare, A., Cotroneo, E., Pampana, E., Ricciardi, F., Gigli, R., Pezzella, F. R., Corsi, F., Giorgianni, A., Baruzzi, F., Pellegrino, C., Terrana, A., Versino, M., Delodovici, M. L., Carimati, F., Cariddi, L. Princiotta, Auteri, W., Di Benedetto, O., Silvagni, U., Perrotta, P., Crispino, E., Petrone, A., Stancati, F., Rizzuto, S., Pugliese, P., Pisani, E., Siniscalchi, A., Gaudiano, C., Pirritano, D., Del Giudice, F., Piano, M., Agostoni, E., Motto, C., Gatti, A., Guccione, A., Tortorella, R., Stecco, A., Guzzardi, G., Del Sette, B., Coppo, L., Baldan, J., Romano, D., Siani, A., Locatelli, G., Saponiero, R., Napolitano, R., De Gregorio, M., Volpe, G., Tenuta, M., Guidetti, G., Biraschi, F., Wulbek, A., Falcou, A., Anzini, A., Mancini, A., De Michele, M., Fausti, S., Di Mascio, M. T., Durastanti, L., Sbardella, E., Mellina, V., Nicolini, E., Comelli, S., Ganau, C., Corraine, S., Fusaro, F., Ferrari, A., Schirru, F., Ledda, V., Secci, S., Melis, M., Piras, V., Moller, J., Padolecchia, R., Allegretti, L., Caldiera, V., Calia, S., Ganci, G., Tassinari, T., Sugo, A., De Nicola, M., Giannoni, M., Bruni, S., Gambelli, E., Provinciali, L., Nuzzi, N. P., Marcheselli, S., Corato, M., Scomazzoni, F., Simionato, F., Roveri, L., Filauri, P., Sacco, S., Orlandi, B., De Santis, F., Tiseo, C., Notturno, F., Ornello, R., Pavia, M., Squassina, G., Cobelli, M., Morassi, M., Magni, E., Invernizzi, P., Pepe, F., Bigni, B., Costa, P., Crabbio, M., Griffini, S., Palmerini, F., Piras, M. P., Gallesio, I., Barbero, S., Ferrandi, D., Dui, G., Fancello, M. C., Zedda, S., Ticca, A., Saddi, M. V., Deiana, G., Rossi, R., Carboni, N., Mela, A., Amistà, P., Russo, M., Iannucci, G., Pinna, V., Di Clemente, L., Santi, M., De Boni, A., De Luca, C., Natrella, M., Fanelli, G., Cristoferi, M., Bottacchi, E., Corso, G., Tosi, P., Sessa, M., Giossi, A., Baietti, Null, Romano, G., Meineri, P., Armentano, A., Versace, P., Arcudi, L., Galvano, G., Petralia, B., Feraco, P., Luppi, G., Giometto, B., Bignamini, V., Piffer, S., Meloni, G. B., Fabio, C., Maiore, M., Pintus, F., Pischedda, A., Manca, A., Mongili, C., Zanda, B., Baule, A., Florio, F., Ciccarese, G., Leone, M., Di Viesti, P., Pappalardo, M. P., Craparo, G., Gallo, C., Monaco, S., Mannino, M., Muto, M., Guarnieri, Gl., Andreone, V., Passalacqua, G., Allegritti, M., Caproni, S., Filizzolo, M., Salmaggi, A., Giordano, A., Marini, C., Frattale, I., Lucente, G., Nozzoli, C., and Lupo, F. A.

Subjects
Stent, Acute stroke, Settore MED/37 - Neuroradiologia, Acute stroke Internal carotid artery diseases Stent Thrombectomy, Neurology (clinical), General Medicine, Settore MED/26, Internal carotid artery diseases, Thrombectomy
Abstract

The management of tandem extracranial internal carotid artery and intracranial large vessel occlusion during endovascular thrombectomy (EVT) for acute ischemic stroke (AIS) has been under-investigated. We sought to investigate outcomes of AIS patients with tandem occlusion (TO) treated with carotid artery stenting (CAS) compared to those not treated with CAS (no-CAS) during EVT.We performed a cohort study using data from AIS patients enrolled in the Italian Registry of Endovascular Treatment in Acute Stroke. Outcomes were 3 months' mortality, functional outcome, complete and successful recanalization, any intracranial hemorrhage, parenchymal hematoma and symptomatic intracerebral hemorrhage.Among 466 AIS patients with TO, CAS patients were 122 and no-CAS patients were 226 (118 excluded). After adjustment for unbalanced variables, CAS was associated with a lower rate of 3 months' mortality (OR 0.407, 95% CI 0.171-0.969, p = 0.042). After adjustment for pre-defined variables, CAS was associated with a lower rate of 3 months' mortality (aOR 0.430, 95% CI 0.187-0.989, p = 0.047) and a higher rate of complete recanalization (aOR 1.986, 95% CI 1.121-3.518, p = 0.019), successful recanalization (aOR 2.433, 95% CI 1.263-4.686, p = 0.008) and parenchymal hematoma (aOR 2.876, 95% CI 1.173-7.050, p = 0.021). CAS was associated with lower 3 months mortality (OR 0.373, 95% CI 0.141-0.982, p = 0.046) and higher rates of successful recanalization (OR 2.082, 95% CI 1.099-3.942, p = 0.024) after adjustment for variables associated with 3 months' mortality and successful recanalization, respectively.Among AIS patients with TO, CAS during EVT was associated with a higher rate of successful reperfusion and a lower rate of 3 months' mortality.

Published
2022

20. Gender Differences in 3-Month Outcomes of Erenumab Treatment—Study on Efficacy and Safety of Treatment With Erenumab in Men

Author

Ornello, Raffaele, primary, Baraldi, Carlo, additional, Guerzoni, Simona, additional, Lambru, Giorgio, additional, Fuccaro, Matteo, additional, Raffaelli, Bianca, additional, Gendolla, Astrid, additional, Barbanti, Piero, additional, Aurilia, Cinzia, additional, Cevoli, Sabina, additional, Favoni, Valentina, additional, Vernieri, Fabrizio, additional, Altamura, Claudia, additional, Russo, Antonio, additional, Silvestro, Marcello, additional, Dalla Valle, Elisabetta, additional, Mancioli, Andrea, additional, Ranieri, Angelo, additional, Alfieri, Gennaro, additional, Latysheva, Nina, additional, Filatova, Elena, additional, Talbot, Jamie, additional, Cheng, Shuli, additional, Holle, Dagny, additional, Scheffler, Armin, additional, Nežádal, Tomáš, additional, Čtrnáctá, Dana, additional, Šípková, Jitka, additional, Matoušová, Zuzana, additional, Sette, Lucia, additional, Casalena, Alfonsina, additional, Maddestra, Maurizio, additional, Viola, Stefano, additional, Affaitati, Giannapia, additional, Giamberardino, Maria Adele, additional, Pistoia, Francesca, additional, Reuter, Uwe, additional, and Sacco, Simona, additional

Published
2021
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22. sj-pdf-1-wso-10.1177_1747493020976681 - Supplemental material for Complications of mechanical thrombectomy for acute ischemic stroke: Incidence, risk factors, and clinical relevance in the Italian Registry of Endovascular Treatment in acute stroke

Author

Salsano, Giancarlo, Pracucci, Giovanni, Mavilio, Nicola, Saia, Valentina, Poggio, Monica B Di, Malfatto, Laura, Sallustio, Fabrizio, Wlderk, Andrea, Limbucci, Nicola, Nencini, Patrizia, Vallone, Stefano, Zini, Andrea, Bigliardi, Guido, Velo, Mariano, Francalanza, Isabella, Gennari, Paola, Tassi, Rossana, Bergui, Mauro, Cerrato, Paolo, Carità, Giuseppe, Azzini, Cristiano, Gasparotti, Roberto, Magoni, Mauro, Isceri, Salvatore, Commodaro, Christian, Cordici, Francesco, Menozzi, Roberto, Latte, Lilia, Cosottini, Mirco, Mancuso, Michelangelo, Comai, Alessio, Franchini, Enrica, Alexandre, Andrea, Marca, Giacomo Della, Puglielli, Edoardo, Casalena, Alfonsina, Causin, Francesco, Baracchini, Claudio, Maggio, Luca Di, Naldi, Andrea, Grazioli, Andrea, Forlivesi, Stefano, Chiumarulo, Luigi, Petruzzellis, Marco, Sanfilippo, Giuseppina, Toscano, Gianpaolo, Cavasin, Nicola, Critelli Adriana, Ganimede, Maria Porzia, Prontera, Maria Pia, Giorgianni Andrea, Mauri, Marco, Auteri, William, Petrone, Alfredo, Cirelli, Carlo, Falcou, Anne, Corraine, Simona, Piras, Valeria, Ganci, Giuseppe, Tassinari, Tiziana, Nuzzi, Nunzio Paolo, Corato, Manuel, Sacco, Simona, Squassina, Guido, Invernizzi, Paolo, Gallesio, Ivan, Ferrandi, Delfina, Dui, Giovanni, Deiana, Gianluca, Amistà, Pietro, Russo, Monia, Pintus, Francesco, Baule, Antonio, Craparo, Giuseppe, Mannino, Marina, Castellan, Lucio, Toni, Danilo, and Mangiafico, Salvatore

Subjects
FOS: Clinical medicine, Cardiology, Medicine, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-pdf-1-wso-10.1177_1747493020976681 for Complications of mechanical thrombectomy for acute ischemic stroke: Incidence, risk factors, and clinical relevance in the Italian Registry of Endovascular Treatment in acute stroke by Giancarlo Salsano, Giovanni Pracucci, Nicola Mavilio, Valentina Saia, Monica B di Poggio, Laura Malfatto, Fabrizio Sallustio, Andrea Wlderk, Nicola Limbucci, Patrizia Nencini, Stefano Vallone, Andrea Zini, Guido Bigliardi, Mariano Velo, Isabella Francalanza, Paola Gennari, Rossana Tassi, Mauro Bergui, Paolo Cerrato, Giuseppe Carità, Cristiano Azzini, Roberto Gasparotti, Mauro Magoni, Salvatore Isceri, Christian Commodaro, Francesco Cordici, Roberto Menozzi, Lilia Latte, Mirco Cosottini, Michelangelo Mancuso, Alessio Comai, Enrica Franchini, Andrea Alexandre, Giacomo Della Marca, Edoardo Puglielli, Alfonsina Casalena, Francesco Causin, Claudio Baracchini, Luca Di Maggio, Andrea Naldi, Andrea Grazioli, Stefano Forlivesi, Luigi Chiumarulo, Marco Petruzzellis, Giuseppina Sanfilippo, Gianpaolo Toscano, Nicola Cavasin, Critelli Adriana, Maria Porzia Ganimede, Maria Pia Prontera, Giorgianni Andrea, Marco Mauri, William Auteri, Alfredo Petrone, Carlo Cirelli, Anne Falcou, Simona Corraine, Valeria Piras, Giuseppe Ganci, Tiziana Tassinari, Nunzio Paolo Nuzzi, Manuel Corato, Simona Sacco, Guido Squassina, Paolo Invernizzi, Ivan Gallesio, Delfina Ferrandi, Giovanni Dui, Gianluca Deiana, Pietro Amistà, Monia Russo, Francesco Pintus, Antonio Baule, Giuseppe Craparo, Marina Mannino, Lucio Castellan, Danilo Toni and Salvatore Mangiafico in International Journal of Stroke

Published
2020
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23. Complications of mechanical thrombectomy for acute ischemic stroke: Incidence, risk factors, and clinical relevance in the Italian Registry of Endovascular Treatment in acute stroke

Author

Salsano, Giancarlo, primary, Pracucci, Giovanni, additional, Mavilio, Nicola, additional, Saia, Valentina, additional, Bandettini di Poggio, Monica, additional, Malfatto, Laura, additional, Sallustio, Fabrizio, additional, Wlderk, Andrea, additional, Limbucci, Nicola, additional, Nencini, Patrizia, additional, Vallone, Stefano, additional, Zini, Andrea, additional, Bigliardi, Guido, additional, Velo, Mariano, additional, Francalanza, Isabella, additional, Gennari, Paola, additional, Tassi, Rossana, additional, Bergui, Mauro, additional, Cerrato, Paolo, additional, Carità, Giuseppe, additional, Azzini, Cristiano, additional, Gasparotti, Roberto, additional, Magoni, Mauro, additional, Isceri, Salvatore, additional, Commodaro, Christian, additional, Cordici, Francesco, additional, Menozzi, Roberto, additional, Latte, Lilia, additional, Cosottini, Mirco, additional, Mancuso, Michelangelo, additional, Comai, Alessio, additional, Franchini, Enrica, additional, Alexandre, Andrea, additional, Marca, Giacomo Della, additional, Puglielli, Edoardo, additional, Casalena, Alfonsina, additional, Causin, Francesco, additional, Baracchini, Claudio, additional, Di Maggio, Luca, additional, Naldi, Andrea, additional, Grazioli, Andrea, additional, Forlivesi, Stefano, additional, Chiumarulo, Luigi, additional, Petruzzellis, Marco, additional, Sanfilippo, Giuseppina, additional, Toscano, Gianpaolo, additional, Cavasin, Nicola, additional, Adriana, Critelli, additional, Ganimede, Maria Porzia, additional, Prontera, Maria Pia, additional, Andrea, Giorgianni, additional, Mauri, Marco, additional, Auteri, William, additional, Petrone, Alfredo, additional, Cirelli, Carlo, additional, Falcou, Anne, additional, Corraine, Simona, additional, Piras, Valeria, additional, Ganci, Giuseppe, additional, Tassinari, Tiziana, additional, Nuzzi, Nunzio Paolo, additional, Corato, Manuel, additional, Sacco, Simona, additional, Squassina, Guido, additional, Invernizzi, Paolo, additional, Gallesio, Ivan, additional, Ferrandi, Delfina, additional, Dui, Giovanni, additional, Deiana, Gianluca, additional, Amistà, Pietro, additional, Russo, Monia, additional, Pintus, Francesco, additional, Baule, Antonio, additional, Craparo, Giuseppe, additional, Mannino, Marina, additional, Castellan, Lucio, additional, Toni, Danilo, additional, and Mangiafico, Salvatore, additional

Published
2020
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24. Association between response to triptans and response to erenumab: real-life data

Author

Frattale, Ilaria, primary, Caponnetto, Valeria, additional, Casalena, Alfonsina, additional, Assetta, Maurizio, additional, Maddestra, Maurizio, additional, Marzoli, Fabio, additional, Affaitati, Giannapia, additional, Giamberardino, Maria Adele, additional, Viola, Stefano, additional, Gabriele, Amleto, additional, Pistoia, Francesca, additional, Cerone, Davide, additional, Marini, Carmine, additional, Sacco, Simona, additional, and Ornello, Raffaele, additional

Published
2020
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25. Conversion From Chronic To Episodic Migraine In Patients Treated With Erenumab: Real-Life Data From An Italian Region

Author

Ornello, Raffaele, primary, Casalena, Alfonsina, additional, Frattale, Ilaria, additional, Caponnetto, Valeria, additional, Gabriele, Amleto, additional, Affaitati, Giannapia, additional, Giamberardino, Maria Adele, additional, Assetta, Maurizio, additional, Maddestra, Maurizio, additional, Marzoli, Fabio, additional, Viola, Stefano, additional, Cerone, Davide, additional, Marini, Carmine, additional, Pistoia, Francesca, additional, and Sacco, Simona, additional

Published
2020
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27. Sex differences in outcome after thrombectomy for acute ischemic stroke. A propensity score-matched study

Author

Casetta, Ilaria, Fainardi, Enrico, Pracucci, Giovanni, Saia, Valentina, Sallustio, Fabrizio, da Ros, Valerio, Nappini, Sergio, Nencini, Patrizia, Bigliardi, Guido, Vinci, Sergio, Grillo, Francesco, Bracco, Sandra, Tassi, Rossana, Bergui, Mauro, Cerrato, Paolo, Saletti, Andrea, De Vito, Alessandro, Gasparotti, Roberto, Magoni, Mauro, Simonetti, Luigi, Zini, Andrea, Ruggiero, Maria, Longoni, Marco, Castellan, Lucio, Malfatto, Laura, Castellini, Paola, Cosottini, Mirco, Comai, Alessio, Franchini, Enrica, Lozupone, Emilio, Della Marca, Giacomo, Puglielli, Edoardo, Casalena, Alfonsina, Baracchini, Claudio, Savio, Daniele, Duc, Enrica, Ricciardi, Giuseppe, Cappellari, Manuel, Chiumarulo, Luigi, Petruzzellis, Marco, Cavallini, Anna, Cavasin, Nicola, Critelli, Adriana, Burdi, Nicola, Boero, Giovanni, Giorgianni, Andrea, Versino, Maurizio, Biraschi, Francesco, Nicolini, Ettore, Comelli, Simone, Melis, Maurizio, Padolecchia, Riccardo, Tassinari, Tiziana, Paolo Nuzzi, Nunzio, Marcheselli, Simona, Sacco, Simona, Invernizzi, Paolo, Gallesio, Ivan, Ferrandi, Delfina, Fancello, Maria, Valeria Saddi, Maria, Russo, Monia, Pischedda, Aldo, Baule, Antonio, Mannino, Marina, Florio, Francesco, Inchingolo, Vincenzo, Elena Flacco, Maria, Romano, Daniele, Silvagni, Umberto, Inzitari, Domenico, Mangiafico, Salvatore, and Toni, Danilo

Abstract

Background and purpose We sought to investigate whether there are gender differences in clinical outcome after stroke due to large vessel occlusion (LVO) after mechanical thrombectomy (EVT) in a large population of real-world patients.Methods From the Italian Registry of Endovascular Thrombectomy, we extracted clinical and outcome data of patients treated for stroke due to large vessel occlusion. We compared clinical and safety outcomes in men and women who underwent EVT alone or in combination with intravenous thrombolysis (IVT) in the total population and in a Propensity Score matched set.Results Among 3422 patients included in the study, 1801 (52.6%) were women. Despite older age at onset (mean 72.4 vs 68.7; p< 0.001), and higher rate of atrial fibrillation (41.7% vs 28.6%; p< 0.001), women had higher probability of 3-month functional independence (adjusted odds ratio-adjOR 1.19; 95% CI 1.02–1.38), of complete recanalization (adjOR 1.25; 95% CI 1.09–1.44) and lower probability of death (adjOR 0.75; 95% CI 0.62–0.90). After propensity-score matching, a well-balanced cohort comprising 1150 men and 1150 women was analyzed, confirming the same results regarding functional outcome (3-month functional independence: OR 1.25; 95% CI 1.04–1.51), and complete recanalization (OR 1.29; 95% CI 1.09–1.53).Conclusions Subject to the limitations of a non-randomized comparison, women with stroke due to LVO treated with mechanical thrombectomy had a better chance to achieve complete recanalization, and 3-month functional independence than men. The results could be driven by women who underwent combined treatment.

Published
2022
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28. Supplemental material for IER-START nomogram for prediction of three-month unfavorable outcome after thrombectomy for stroke

Author

Cappellari, Manuel, Mangiafico, Salvatore, Saia, Valentina, Pracucci, Giovanni, Nappini, Sergio, Nencini, Patrizia, Konda, Daniel, Sallustio, Fabrizio, Vallone, Stefano, Zini, Andrea, Bracco, Sandra, Tassi, Rossana, Bergui, Mauro, Cerrato, Paolo, Pitrone, Antonio, Grillo, Francesco, Saletti, Andrea, Vito, Alessandro De, Gasparotti, Roberto, Magoni, Mauro, Puglielli, Edoardo, Casalena, Alfonsina, Causin, Francesco, Baracchini, Claudio, Castellan, Lucio, Malfatto, Laura, Menozzi, Roberto, Scoditti, Umberto, Comelli, Chiara, Duc, Enrica, Comai, Alessio, Franchini, Enrica, Cosottini, Mirco, Mancuso, Michelangelo, Peschillo, Simone, Michele, Manuela De, Giorgianni, Andrea, Delodovici, Maria Luisa, Lafe, Elvis, Denaro, Maria F, Burdi, Nicola, Internò, Saverio, Cavasin, Nicola, Critelli, Adriana, Chiumarulo, Luigi, Petruzzellis, Marco, Doddi, Marco, Carolei, Antonio, Auteri, William, Petrone, Alfredo, Padolecchia, Riccardo, Tassinari, Tiziana, Pavia, Marco, Invernizzi, Paolo, Turcato, Gianni, Forlivesi, Stefano, Ciceri, Elisa Francesca Maria, Bonetti, Bruno, Inzitari, Domenico, and Toni, Danilo

Subjects
FOS: Clinical medicine, Cardiology, Medicine, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental Material for IER-START nomogram for prediction of three-month unfavorable outcome after thrombectomy for stroke by Manuel Cappellari, Salvatore Mangiafico, Valentina Saia, Giovanni Pracucci, Sergio Nappini, Patrizia Nencini, Daniel Konda, Fabrizio Sallustio, Stefano Vallone, Andrea Zini, Sandra Bracco, Rossana Tassi, Mauro Bergui, Paolo Cerrato, Antonio Pitrone, Francesco Grillo, Andrea Saletti, Alessandro De Vito, Roberto Gasparotti, Mauro Magoni, Edoardo Puglielli, Alfonsina Casalena, Francesco Causin, Claudio Baracchini, Lucio Castellan, Laura Malfatto, Roberto Menozzi, Umberto Scoditti, Chiara Comelli, Enrica Duc, Alessio Comai, Enrica Franchini, Mirco Cosottini, Michelangelo Mancuso, Simone Peschillo, Manuela De Michele, Andrea Giorgianni, Maria Luisa Delodovici, Elvis Lafe, Maria F Denaro, Nicola Burdi, Saverio Internò, Nicola Cavasin, Adriana Critelli, Luigi Chiumarulo, Marco Petruzzellis, Marco Doddi, Antonio Carolei, William Auteri, Alfredo Petrone, Riccardo Padolecchia, Tiziana Tassinari, Marco Pavia, Paolo Invernizzi, Gianni Turcato, Stefano Forlivesi, Elisa Francesca Maria Ciceri, Bruno Bonetti, Domenico Inzitari and Danilo Toni in International Journal of Stroke

Published
2019
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29. IER-START nomogram for prediction of three-month unfavorable outcome after thrombectomy for stroke

Author

Cappellari, Manuel, primary, Mangiafico, Salvatore, additional, Saia, Valentina, additional, Pracucci, Giovanni, additional, Nappini, Sergio, additional, Nencini, Patrizia, additional, Konda, Daniel, additional, Sallustio, Fabrizio, additional, Vallone, Stefano, additional, Zini, Andrea, additional, Bracco, Sandra, additional, Tassi, Rossana, additional, Bergui, Mauro, additional, Cerrato, Paolo, additional, Pitrone, Antonio, additional, Grillo, Francesco, additional, Saletti, Andrea, additional, De Vito, Alessandro, additional, Gasparotti, Roberto, additional, Magoni, Mauro, additional, Puglielli, Edoardo, additional, Casalena, Alfonsina, additional, Causin, Francesco, additional, Baracchini, Claudio, additional, Castellan, Lucio, additional, Malfatto, Laura, additional, Menozzi, Roberto, additional, Scoditti, Umberto, additional, Comelli, Chiara, additional, Duc, Enrica, additional, Comai, Alessio, additional, Franchini, Enrica, additional, Cosottini, Mirco, additional, Mancuso, Michelangelo, additional, Peschillo, Simone, additional, De Michele, Manuela, additional, Giorgianni, Andrea, additional, Luisa Delodovici, Maria, additional, Lafe, Elvis, additional, Denaro, Maria F, additional, Burdi, Nicola, additional, Internò, Saverio, additional, Cavasin, Nicola, additional, Critelli, Adriana, additional, Chiumarulo, Luigi, additional, Petruzzellis, Marco, additional, Doddi, Marco, additional, Carolei, Antonio, additional, Auteri, William, additional, Petrone, Alfredo, additional, Padolecchia, Riccardo, additional, Tassinari, Tiziana, additional, Pavia, Marco, additional, Invernizzi, Paolo, additional, Turcato, Gianni, additional, Forlivesi, Stefano, additional, Francesca Maria Ciceri, Elisa, additional, Bonetti, Bruno, additional, Inzitari, Domenico, additional, and Toni, Danilo, additional

Published
2019
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30. The First Historically Reported Italian Family with FTD/ALS Teaches a Lesson on C9orf72 RE: Clinical Heterogeneity and Oligogenic Inheritance

Author

Giannoccaro, Maria Pia, primary, Bartoletti-Stella, Anna, additional, Piras, Silvia, additional, Casalena, Alfonsina, additional, Oppi, Federico, additional, Ambrosetto, Giovanni, additional, Montagna, Pasquale, additional, Liguori, Rocco, additional, Parchi, Piero, additional, and Capellari, Sabina, additional

Published
2018
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34. The First Historically Reported Italian Family with FTD/ALS Teaches a Lesson on C9orf72 RE: Clinical Heterogeneity and Oligogenic Inheritance

Author

Pasquale Montagna, Sabina Capellari, Piero Parchi, Giovanni Ambrosetto, Silvia Piras, Federico Oppi, Alfonsina Casalena, Maria Pia Giannoccaro, Anna Bartoletti-Stella, Rocco Liguori, Giannoccaro, Maria Pia, Bartoletti-Stella, Anna, Piras, Silvia, Casalena, Alfonsina, Oppi, Federico, Ambrosetto, Giovanni, Montagna, Pasquale, Liguori, Rocco, Parchi, Piero, and Capellari, Sabina

Subjects
Adult, Male, 0301 basic medicine, Multifactorial Inheritance, FTDALS1, 03 medical and health sciences, 0302 clinical medicine, C9orf72 gene, C9orf72, mental disorders, medicine, Humans, Dementia, Genetic Testing, Cognitive decline, Amyotrophic lateral sclerosis, Amyotrophic lateral sclerosi, Adaptor Proteins, Signal Transducing, Cerebral Cortex, Genetics, DNA Repeat Expansion, Membrane Glycoproteins, C9orf72 Protein, business.industry, General Neuroscience, Amyotrophic Lateral Sclerosis, Oligogenic Inheritance, General Medicine, Middle Aged, medicine.disease, Pedigree, Psychiatry and Mental health, Clinical Psychology, 030104 developmental biology, ITM2B, Schizophrenia, Frontotemporal Dementia, Mutation, Female, Geriatrics and Gerontology, Trinucleotide repeat expansion, business, familial ALS/FTD, 030217 neurology & neurosurgery, Frontotemporal dementia
Abstract

Background In 1969, Dazzi and Finizio reported the second observation of frontotemporal dementia (FTD) - amyotrophic lateral sclerosis (ALS) association in a large Italian kindred affected by an autosomal dominant form of ALS with high penetrance, frequent bulbar onset, and frequent cognitive decline. Objective To expand the original characterization of this family and report the link with the C9orf72 repeat expansion (RE). Methods We followed or reviewed the medical records of thirteen patients belonging to the original family and performed genetic analyses in four individuals. Results Eight patients presented with ALS, four with FTD, and one with schizophrenia. The C9orf72 RE was found in three patients but not in the healthy survivor. Additionally, we found a novel possible pathogenic variant in the ITM2B gene in one patient with a complex phenotype, associating movement disorders, psychiatric and cognitive features, deafness, and optic atrophy. The neuropathological examination of this patient did not show the classical features of ITM2B mutation related dementias suggesting that the putative pathogenic mechanism does not involve cellular mislocalization of the protein or the formation of amyloid plaques. Conclusion We showed that the original Italian pedigree described with FTD/ALS carries the C9orf72 RE. Moreover, the finding of an additional mutation in another dementia causing gene in a patient with a more complex phenotype suggests a possible role of genetic modifiers in the disease. Together with other reports showing the coexistence of mutations in multiple ALS/FTD causative genes in the same family, our study supports an oligogenic etiology of ALS/FTD.

Published
2018

35. Complications of mechanical thrombectomy for acute ischemic stroke: Incidence, risk factors, and clinical relevance in the Italian Registry of Endovascular Treatment in acute stroke.

Author

Salsano G, Pracucci G, Mavilio N, Saia V, Bandettini di Poggio M, Malfatto L, Sallustio F, Wlderk A, Limbucci N, Nencini P, Vallone S, Zini A, Bigliardi G, Velo M, Francalanza I, Gennari P, Tassi R, Bergui M, Cerrato P, Carità G, Azzini C, Gasparotti R, Magoni M, Isceri S, Commodaro C, Cordici F, Menozzi R, Latte L, Cosottini M, Mancuso M, Comai A, Franchini E, Alexandre A, Marca GD, Puglielli E, Casalena A, Causin F, Baracchini C, Di Maggio L, Naldi A, Grazioli A, Forlivesi S, Chiumarulo L, Petruzzellis M, Sanfilippo G, Toscano G, Cavasin N, Adriana C, Ganimede MP, Prontera MP, Andrea G, Mauri M, Auteri W, Petrone A, Cirelli C, Falcou A, Corraine S, Piras V, Ganci G, Tassinari T, Nuzzi NP, Corato M, Sacco S, Squassina G, Invernizzi P, Gallesio I, Ferrandi D, Dui G, Deiana G, Amistà P, Russo M, Pintus F, Baule A, Craparo G, Mannino M, Castellan L, Toni D, and Mangiafico S

Subjects
Humans, Incidence, Italy epidemiology, Registries, Risk Factors, Treatment Outcome, Brain Ischemia epidemiology, Endovascular Procedures adverse effects, Ischemic Stroke, Stroke epidemiology, Stroke therapy, Thrombectomy adverse effects
Abstract

Background: There are limited data concerning procedure-related complications of endovascular thrombectomy for large vessel occlusion strokes., Aims: We evaluated the cumulative incidence, the clinical relevance in terms of increased disability and mortality, and risk factors for complications., Methods: From January 2011 to December 2017, 4799 patients were enrolled by 36 centers in the Italian Registry of Endovascular Stroke Treatment. Data on demographic and procedural characteristics, complications, and clinical outcome at three months were prospectively collected., Results: The complications cumulative incidence was 201 per 1000 patients undergoing endovascular thrombectomy. Ongoing antiplatelet therapy (p < 0.01; OR 1.82, 95% CI: 1.21-2.73) and large vessel occlusion site (carotid-T, p < 0.03; OR 3.05, 95% CI: 1.13-8.19; M2-segment-MCA, p < 0.01; OR 4.54, 95% CI: 1.66-12.44) were associated with a higher risk of subarachnoid hemorrhage/arterial perforation. Thrombectomy alone (p < 0.01; OR 0.50, 95% CI: 0.31-0.83) and younger age (p < 0.04; OR 0.98, 95% CI: 0.97-0.99) revealed a lower risk of developing dissection. M2-segment-MCA occlusion (p < 0.01; OR 0.35, 95% CI: 0.19-0.64) and hypertension (p < 0.04; OR 0.77, 95% CI: 0.6-0.98) were less related to clot embolization. Higher NIHSS at onset (p < 0.01; OR 1.04, 95% CI: 1.02-1.06), longer groin-to-reperfusion time (p < 0.01; OR 1.05, 95% CI: 1.02-1.07), diabetes (p < 0.01; OR 1.67, 95% CI: 1.25-2.23), and LVO site (carotid-T, p < 0.01; OR 1.96, 95% CI: 1.26-3.05; M2-segment-MCA, p < 0.02; OR 1.62, 95% CI: 1.08-2.42) were associated with a higher risk of developing symptomatic intracerebral hemorrhage compared to no/asymptomatic intracerebral hemorrhage. The subgroup of patients treated with thrombectomy alone presented a lower risk of symptomatic intracerebral hemorrhage (p < 0.01; OR 0.70; 95% CI: 0.55-0.90). Subarachnoid hemorrhage/arterial perforation and symptomatic intracerebral hemorrhage after endovascular thrombectomy worsen both functional independence and mortality at three-month follow-up (p < 0.01). Distal embolization is associated with neurological deterioration (p < 0.01), while arterial dissection did not affect clinical outcome at follow-up., Conclusions: Complications globally considered are not uncommon and may result in poor clinical outcome. Early recognition of risk factors might help to prevent complications and manage them appropriately in order to maximize endovascular thrombectomy benefits.

Published
2021
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36. Mechanical Thrombectomy for Acute Intracranial Carotid Occlusion with Patent Intracranial Arteries : The Italian Registry of Endovascular Treatment in Acute Stroke.

Author

Sallustio F, Saia V, Marrama F, Pracucci G, Gandini R, Koch G, Mascolo AP, D'Agostino F, Rocco A, Argiro' R, Nezzo M, Morosetti D, Wlderk A, Da Ros V, Diomedi M, Renieri L, Nencini P, Vallone S, Zini A, Bigliardi G, Caragliano A, Francalanza I, Bracco S, Tassi R, Bergui M, Naldi A, Saletti A, De Vito A, Gasparotti R, Magoni M, Cirillo L, Commodaro C, Biguzzi S, Castellan L, Malfatto L, Menozzi R, Grisendi I, Cosottini M, Orlandi G, Comai A, Franchini E, D'Argento F, Frisullo G, Puglielli E, Casalena A, Causin F, Baracchini C, Boghi A, Chianale G, Augelli R, Cappellari M, Chiumarulo L, Petruzzellis M, Sgreccia A, Tosi P, Cavasin N, Critelli A, Semeraro V, Boero G, Vizzari F, Cariddi LP, Di Benedetto O, Pugliese P, Iacobucci M, De Michele M, Fusaro F, Moller J, Allegretti L, Tassinari T, Nuzzi NP, Marcheselli S, Sacco S, Pavia M, Invernizzi P, Gallesio I, Ruiz L, Zedda S, Rossi R, Amistà P, Russo M, Pintus F, Sanna A, Craparo G, Mannino M, Inzitari D, Mangiafico S, and Toni D

Subjects
Aged, Carotid Arteries, Humans, Italy, Registries, Retrospective Studies, Treatment Outcome, Brain Ischemia diagnostic imaging, Brain Ischemia surgery, Endovascular Procedures, Stroke diagnostic imaging, Stroke surgery, Thrombectomy
Abstract

Purpose: Intracranial carotid artery occlusion represents an underinvestigated cause of acute ischemic stroke as well as an indication for mechanical thrombectomy. We investigated baseline and procedural characteristics, outcomes and predictors of outcome in patients with acute ischemic stroke secondary to intracranial carotid artery occlusion., Methods: A retrospective analysis of the Italian Registry of Endovascular Treatment in Acute Stroke was performed. Patients with intracranial carotid artery occlusion (infraclinoid and supraclinoid) with or without cervical artery occlusion but with patent intracranial arteries were included. The 3‑month functional independence, mortality, successful reperfusion and symptomatic intracranial hemorrhage were evaluated., Results: Intracranial carotid artery occlusion with patent intracranial arteries was diagnosed in 387 out of 4940 (7.8%) patients. The median age was 74 years and median baseline National Institute of Health Stroke Scale (NIHSS) was 18. Functional independence was achieved in 130 (34%) patients, successful reperfusion in 289 (75%) and symptomatic intracranial hemorrhage in 33 (9%), whereas mortality occurred in 111 (29%) patients. In univariate analysis functional independence was associated with lower age, lower NIHSS at presentation, higher rate of successful reperfusion and lower rate of symptomatic intracranial hemorrhage. Multivariable regression analysis found age (odds ratio, OR:1.03; P = 0.006), NIHSS at presentation (OR: 1.07; P < 0.001), diabetes (OR: 2.60; P = 0.002), successful reperfusion (OR:0.20; P < 0.001) and symptomatic intracranial hemorrhage (OR: 4.17; P < 0.001) as the best independent predictors of outcome., Conclusion: Our study showed a not negligible rate of intracranial carotid artery occlusion with patent intracranial arteries, presenting mostly as severe stroke, with an acceptable rate of 3‑month functional independence. Age, NIHSS at presentation and successful reperfusion were the best independent predictors of outcome.

Published
2021
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37. IER-START nomogram for prediction of three-month unfavorable outcome after thrombectomy for stroke.

Author

Cappellari M, Mangiafico S, Saia V, Pracucci G, Nappini S, Nencini P, Konda D, Sallustio F, Vallone S, Zini A, Bracco S, Tassi R, Bergui M, Cerrato P, Pitrone A, Grillo F, Saletti A, De Vito A, Gasparotti R, Magoni M, Puglielli E, Casalena A, Causin F, Baracchini C, Castellan L, Malfatto L, Menozzi R, Scoditti U, Comelli C, Duc E, Comai A, Franchini E, Cosottini M, Mancuso M, Peschillo S, De Michele M, Giorgianni A, Luisa Delodovici M, Lafe E, Denaro MF, Burdi N, Internò S, Cavasin N, Critelli A, Chiumarulo L, Petruzzellis M, Doddi M, Carolei A, Auteri W, Petrone A, Padolecchia R, Tassinari T, Pavia M, Invernizzi P, Turcato G, Forlivesi S, Francesca Maria Ciceri E, Bonetti B, Inzitari D, and Toni D

Subjects
Cohort Studies, Humans, Italy, Nomograms, Registries, Retrospective Studies, Thrombectomy, Treatment Outcome, Brain Ischemia surgery, Endovascular Procedures, Stroke surgery
Abstract

Background: The applicability of the current models for predicting functional outcome after thrombectomy in strokes with large vessel occlusion (LVO) is affected by a moderate predictive performance., Aims: We aimed to develop and validate a nomogram with pre- and post-treatment factors for prediction of the probability of unfavorable outcome in patients with anterior and posterior LVO who received bridging therapy or direct thrombectomy <6 h of stroke onset., Methods: We conducted a cohort study on patients data collected prospectively in the Italian Endovascular Registry (IER). Unfavorable outcome was defined as three-month modified Rankin Scale (mRS) score 3-6. Six predictors, including NIH Stroke Scale (NIHSS) score, age, pre-stroke mRS score, bridging therapy or direct thrombectomy, grade of recanalization according to the thrombolysis in cerebral ischemia (TICI) grading system, and onset-to-end procedure time were identified a priori by three stroke experts. To generate the IER-START, the pre-established predictors were entered into a logistic regression model. The discriminative performance of the model was assessed by using the area under the receiver operating characteristic curve (AUC-ROC)., Results: A total of 1802 patients with complete data for generating the IER-START was randomly dichotomized into training ( n  = 1219) and test ( n  = 583) sets. The AUC-ROC of IER-START was 0.838 (95% confidence interval [CI]): 0.816-0.869) in the training set, and 0.820 (95% CI: 0.786-0.854) in the test set., Conclusions: The IER-START nomogram is the first prognostic model developed and validated in the largest population of stroke patients currently candidates to thrombectomy which reliably calculates the probability of three-month unfavorable outcome.

Published
2020
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