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15 results on '"Casanova, Alexandre G."'

2. Author Correction: Cytoskeleton remodeling induced by SMYD2 methyltransferase drives breast cancer metastasis

Author

Casanova, Alexandre G., Roth, Gael S., Hausmann, Simone, Lu, Xiaoyin, Bischoff, Ludivine J. M., Froeliger, Emilie M., Belmudes, Lucid, Bourova-Flin, Ekaterina, Flores, Natasha M., Benitez, Ana Morales, Chasan, Tourkian, Caporicci, Marcello, Vayr, Jessica, Blanchet, Sandrine, Ielasi, Francesco, Rousseaux, Sophie, Hainaut, Pierre, Gozani, Or, Le Romancer, Muriel, Couté, Yohann, Palencia, Andres, Mazur, Pawel K., and Reynoird, Nicolas

Published
2024
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3. Cytoskeleton remodeling induced by SMYD2 methyltransferase drives breast cancer metastasis

Author

Casanova, Alexandre G., Roth, Gael S., Hausmann, Simone, Lu, Xiaoyin, Bischoff, Ludivine J. M., Froeliger, Emilie M., Belmudes, Lucid, Bourova-Flin, Ekaterina, Flores, Natasha M., Benitez, Ana Morales, Chasan, Tourkian, Caporicci, Marcello, Vayr, Jessica, Blanchet, Sandrine, Ielasi, Francesco, Rousseaux, Sophie, Hainaut, Pierre, Gozani, Or, Le Romancer, Muriel, Couté, Yohann, Palencia, Andres, Mazur, Pawel K., and Reynoird, Nicolas

Published
2024
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5. Cytoskeleton remodeling induced by SMYD2 methyltransferase drives breast cancer metastasis

Author

Casanova, Alexandre G, primary, Roth, Gael S, additional, Hausmann, Simone, additional, Lu, Xiaoyin, additional, Belmudes, Lucid, additional, Bourova-Flin, Ekaterina, additional, Flores, Natasha M, additional, Benitez, Ana Morales, additional, Caporicci, Marcello, additional, Vayr, Jessica, additional, Blanchet, Sandrine, additional, Ielasi, Francesco, additional, Rousseaux, Sophie, additional, Hainaut, Pierre, additional, Gozani, Or, additional, Coute, Yohann, additional, Palencia, Andres, additional, Mazur, Pawel K, additional, and Reynoird, Nicolas, additional

Published
2023
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6. Supplementary Data from SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation–Phosphorylation Cross-talk

Author

Lukinović, Valentina, primary, Hausmann, Simone, primary, Roth, Gael S., primary, Oyeniran, Clement, primary, Ahmad, Tanveer, primary, Tsao, Ning, primary, Brickner, Joshua R., primary, Casanova, Alexandre G., primary, Chuffart, Florent, primary, Benitez, Ana Morales, primary, Vayr, Jessica, primary, Rodell, Rebecca, primary, Tardif, Marianne, primary, Jansen, Pascal W.T.C., primary, Couté, Yohann, primary, Vermeulen, Michiel, primary, Hainaut, Pierre, primary, Mazur, Pawel K., primary, Mosammaparast, Nima, primary, and Reynoird, Nicolas, primary

Published
2023
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7. Data from SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation–Phosphorylation Cross-talk

Author

Lukinović, Valentina, primary, Hausmann, Simone, primary, Roth, Gael S., primary, Oyeniran, Clement, primary, Ahmad, Tanveer, primary, Tsao, Ning, primary, Brickner, Joshua R., primary, Casanova, Alexandre G., primary, Chuffart, Florent, primary, Benitez, Ana Morales, primary, Vayr, Jessica, primary, Rodell, Rebecca, primary, Tardif, Marianne, primary, Jansen, Pascal W.T.C., primary, Couté, Yohann, primary, Vermeulen, Michiel, primary, Hainaut, Pierre, primary, Mazur, Pawel K., primary, Mosammaparast, Nima, primary, and Reynoird, Nicolas, primary

Published
2023
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8. Supplementary Table from SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation–Phosphorylation Cross-talk

Author

Lukinović, Valentina, primary, Hausmann, Simone, primary, Roth, Gael S., primary, Oyeniran, Clement, primary, Ahmad, Tanveer, primary, Tsao, Ning, primary, Brickner, Joshua R., primary, Casanova, Alexandre G., primary, Chuffart, Florent, primary, Benitez, Ana Morales, primary, Vayr, Jessica, primary, Rodell, Rebecca, primary, Tardif, Marianne, primary, Jansen, Pascal W.T.C., primary, Couté, Yohann, primary, Vermeulen, Michiel, primary, Hainaut, Pierre, primary, Mazur, Pawel K., primary, Mosammaparast, Nima, primary, and Reynoird, Nicolas, primary

Published
2023
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10. SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation–Phosphorylation Cross-talk

Author

Lukinović, Valentina, primary, Hausmann, Simone, additional, Roth, Gael S., additional, Oyeniran, Clement, additional, Ahmad, Tanveer, additional, Tsao, Ning, additional, Brickner, Joshua R., additional, Casanova, Alexandre G., additional, Chuffart, Florent, additional, Benitez, Ana Morales, additional, Vayr, Jessica, additional, Rodell, Rebecca, additional, Tardif, Marianne, additional, Jansen, Pascal W.T.C., additional, Couté, Yohann, additional, Vermeulen, Michiel, additional, Hainaut, Pierre, additional, Mazur, Pawel K., additional, Mosammaparast, Nima, additional, and Reynoird, Nicolas, additional

Published
2022
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11. Aberrant RNA methylation triggers recruitment of an alkylation repair complex

Author

Tsao, Ning, primary, Brickner, Joshua R., additional, Rodell, Rebecca, additional, Ganguly, Adit, additional, Wood, Matthew, additional, Oyeniran, Clement, additional, Ahmad, Tanveer, additional, Sun, Hua, additional, Bacolla, Albino, additional, Zhang, Lisheng, additional, Lukinović, Valentina, additional, Soll, Jennifer M., additional, Townley, Brittany A., additional, Casanova, Alexandre G., additional, Tainer, John A., additional, He, Chuan, additional, Vindigni, Alessandro, additional, Reynoird, Nicolas, additional, and Mosammaparast, Nima, additional

Published
2021
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12. Aberrant RNA methylation triggers recruitment of an alkylation repair complex

Author

Tsao, Ning, Brickner, Joshua R., Rodell, Rebecca, Ganguly, Adit, Wood, Matthew, Oyeniran, Clement, Ahmad, Tanveer, Sun, Hua, Bacolla, Albino, Zhang, Lisheng, Lukinović, Valentina, Soll, Jennifer M., Townley, Brittany A., Casanova, Alexandre G., Tainer, John A., He, Chuan, Vindigni, Alessandro, Reynoird, Nicolas, Mosammaparast, Nima, Tsao, Ning, Brickner, Joshua R., Rodell, Rebecca, Ganguly, Adit, Wood, Matthew, Oyeniran, Clement, Ahmad, Tanveer, Sun, Hua, Bacolla, Albino, Zhang, Lisheng, Lukinović, Valentina, Soll, Jennifer M., Townley, Brittany A., Casanova, Alexandre G., Tainer, John A., He, Chuan, Vindigni, Alessandro, Reynoird, Nicolas, and Mosammaparast, Nima

Abstract

Central to genotoxic responses is their ability to sense highly specific signals to activate the appropriate repair response. We previously reported that the activation of the ASCC-ALKBH3 repair pathway is exquisitely specific to alkylation damage in human cells. Yet the mechanistic basis for the selectivity of this pathway was not immediately obvious. Here, we demonstrate that RNA but not DNA alkylation is the initiating signal for this process. Aberrantly methylated RNA is sufficient to recruit ASCC, while an RNA dealkylase suppresses ASCC recruitment during chemical alkylation. In turn, recruitment of ASCC during alkylation damage, which is mediated by the E3 ubiquitin ligase RNF113A, suppresses transcription and R-loop formation. We further show that alkylated pre-mRNA is sufficient to activate RNF113A E3 ligase in vitro in a manner dependent on its RNA binding Zn-finger domain. Together, our work identifies an unexpected role for RNA damage in eliciting a specific response to genotoxins. © 2021 The Authors

Published
2021

14. Aberrant RNA methylation triggers recruitment of an alkylation repair complex

Author

Brickner, Joshua R., primary, Tsao, Ning, additional, Rodell, Rebecca, additional, Oyeniran, Clement, additional, Lukinović, Valentina, additional, Bacolla, Albino, additional, Zhang, Lisheng, additional, Soll, Jennifer M., additional, Casanova, Alexandre G., additional, Ganguly, Adit, additional, He, Chuan, additional, Tainer, John A., additional, Reynoird, Nicolas, additional, and Mosammaparast, Nima, additional

Published
2020
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15. Cytoskeleton remodeling induced by SMYD2 methyltransferase drives breast cancer metastasis.

Author

Casanova AG, Roth GS, Hausmann S, Lu X, Belmudes L, Bourova-Flin E, Flores NM, Benitez AM, Caporicci M, Vayr J, Blanchet S, Ielasi F, Rousseaux S, Hainaut P, Gozani O, Couté Y, Palencia A, Mazur PK, and Reynoird N

Abstract

Malignant forms of breast cancer refractory to existing therapies remain a major unmet health issue, primarily due to metastatic spread. A better understanding of the mechanisms at play will provide better insights for alternative treatments to prevent breast cancer cells dispersion. Here, we identify the lysine methyltransferase SMYD2 as a clinically actionable master regulator of breast cancer metastasis. While SMYD2 is overexpressed in aggressive breast cancers, we notice that it is not required for primary tumor growth. However, mammary-epithelium specific SMYD2 ablation increases mouse overall survival by blocking the primary tumor cells ability to metastasize. Mechanistically, we identify BCAR3 as a genuine physiological substrate of SMYD2 in breast cancer cells. BCAR3 monomethylated at lysine K334 (K334me1) is recognized by a novel methyl-binding domain present in FMNLs proteins. These actin cytoskeleton regulators are recruited at the cell edges by the SMYD2 methylation signaling and modulates lamellipodia properties. Breast cancer cells with impaired BCAR3 methylation loose migration and invasiveness capacity in vitro and are ineffective in promoting metastases in vivo . Remarkably, SMYD2 pharmacologic inhibition efficiently impairs the metastatic spread of breast cancer cells, PDX and aggressive mammary tumors from genetically engineered mice. This study provides a rationale for innovative therapeutic prevention of malignant breast cancer metastatic progression by targeting the SMYD2-BCAR3-FMNL axis.

Published
2023
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