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21 results on '"Caserini, Roberto"'

3. Data from Microenvironment-Modulated Metastatic CD133+/CXCR4+/EpCAM− Lung Cancer–Initiating Cells Sustain Tumor Dissemination and Correlate with Poor Prognosis

Author

Bertolini, Giulia, primary, D'Amico, Lucia, primary, Moro, Massimo, primary, Landoni, Elena, primary, Perego, Paola, primary, Miceli, Rosalba, primary, Gatti, Laura, primary, Andriani, Francesca, primary, Wong, Donald, primary, Caserini, Roberto, primary, Tortoreto, Monica, primary, Milione, Massimo, primary, Ferracini, Riccardo, primary, Mariani, Luigi, primary, Pastorino, Ugo, primary, Roato, Ilaria, primary, Sozzi, Gabriella, primary, and Roz, Luca, primary

Published
2023
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4. Supplementary Table S2 from Microenvironment-Modulated Metastatic CD133+/CXCR4+/EpCAM− Lung Cancer–Initiating Cells Sustain Tumor Dissemination and Correlate with Poor Prognosis

Author

Bertolini, Giulia, primary, D'Amico, Lucia, primary, Moro, Massimo, primary, Landoni, Elena, primary, Perego, Paola, primary, Miceli, Rosalba, primary, Gatti, Laura, primary, Andriani, Francesca, primary, Wong, Donald, primary, Caserini, Roberto, primary, Tortoreto, Monica, primary, Milione, Massimo, primary, Ferracini, Riccardo, primary, Mariani, Luigi, primary, Pastorino, Ugo, primary, Roato, Ilaria, primary, Sozzi, Gabriella, primary, and Roz, Luca, primary

Published
2023
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6. Highly Tumorigenic Lung Cancer CD133⁺ Cells Display Stem-Like Features and Are Spared by Cisplatin Treatment

Author

Bertolini, Giulia, Roz, Luca, Perego, Paola, Tortoreto, Monica, Fontanella, Enrico, Gatti, Laura, Pratesi, Graziella, Fabbri, Alessandra, Andriani, Francesca, Tinelli, Stella, Roz, Elena, Caserini, Roberto, Lo Vullo, Salvatore, Camerini, Tiziana, Mariani, Luigi, Delia, Domenico, Calabrò, Elisa, Pastorino, Ugo, Sozzi, Gabriella, and Croce, Carlo M.

Published
2009
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7. Author Correction: Establishment of patient derived xenografts as functional testing of lung cancer aggressiveness

Author

Moro, Massimo, primary, Bertolini, Giulia, additional, Caserini, Roberto, additional, Borzi, Cristina, additional, Boeri, Mattia, additional, Fabbri, Alessandra, additional, Leone, Giorgia, additional, Gasparini, Patrizia, additional, Galeone, Carlotta, additional, Pelosi, Giuseppe, additional, Roz, Luca, additional, Sozzi, Gabriella, additional, and Pastorino, Ugo, additional

Published
2018
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8. Establishment of patient derived xenografts as functional testing of lung cancer aggressiveness

Author

Moro, Massimo, primary, Bertolini, Giulia, additional, Caserini, Roberto, additional, Borzi, Cristina, additional, Boeri, Mattia, additional, Fabbri, Alessandra, additional, Leone, Giorgia, additional, Gasparini, Patrizia, additional, Galeone, Carlotta, additional, Pelosi, Giuseppe, additional, Roz, Luca, additional, Sozzi, Gabriella, additional, and Pastorino, Ugo, additional

Published
2017
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9. Anaplastic lymphoma kinase aberrations correlate with metastatic features in pediatric rhabdomyosarcoma

Author

Gasparini, Patrizia, primary, Casanova, Michela, additional, Villa, Raffaella, additional, Collini, Paola, additional, Alaggio, Rita, additional, Zin, Angelica, additional, Bonvini, Paolo, additional, Antonescu, Cristina R, additional, Boldrini, Renata, additional, Caserini, Roberto, additional, Moro, Massimo, additional, Centonze, Giovanni, additional, Meazza, Cristina, additional, Massimino, Maura, additional, Bergamaschi, Luca, additional, Luksch, Roberto, additional, Chiaravalli, Stefano, additional, Bisogno, Gianni, additional, Zaffaroni, Nadia, additional, Daidone, MariaGrazia, additional, Sozzi, Gabriella, additional, and Ferrari, Andrea, additional

Published
2016
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10. Conversion to stem-cell state in response to microenvironmental cues is regulated by balance between epithelial and mesenchymal features in lung cancer cells

Author

Andriani, Francesca, primary, Bertolini, Giulia, additional, Facchinetti, Federica, additional, Baldoli, Erika, additional, Moro, Massimo, additional, Casalini, Patrizia, additional, Caserini, Roberto, additional, Milione, Massimo, additional, Leone, Giorgia, additional, Pelosi, Giuseppe, additional, Pastorino, Ugo, additional, Sozzi, Gabriella, additional, and Roz, Luca, additional

Published
2015
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11. Microenvironment-Modulated Metastatic CD133+/CXCR4+/EpCAM− Lung Cancer–Initiating Cells Sustain Tumor Dissemination and Correlate with Poor Prognosis

Author

Bertolini, Giulia, primary, D'Amico, Lucia, additional, Moro, Massimo, additional, Landoni, Elena, additional, Perego, Paola, additional, Miceli, Rosalba, additional, Gatti, Laura, additional, Andriani, Francesca, additional, Wong, Donald, additional, Caserini, Roberto, additional, Tortoreto, Monica, additional, Milione, Massimo, additional, Ferracini, Riccardo, additional, Mariani, Luigi, additional, Pastorino, Ugo, additional, Roato, Ilaria, additional, Sozzi, Gabriella, additional, and Roz, Luca, additional

Published
2015
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12. Abstract 1395: Conversion to stem cell state in response to microenvironmental cues is regulated by balance between epithelial and mesenchymal features in lung cancer

Author

Andriani, Francesca, primary, Bertolini, Giulia, additional, Facchinetti, Federica, additional, Baldoli, Erika, additional, Moro, Massimo, additional, Casalini, Patrizia, additional, Caserini, Roberto, additional, Pastorino, Ugo, additional, Sozzi, Gabriella, additional, and Roz, Luca, additional

Published
2015
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18. Highly tumorigenic lung cancer CD133 + cells display stem-like features and are spared by cisplatin treatment

Author

Bertolini, Giulia, primary, Roz, Luca, additional, Perego, Paola, additional, Tortoreto, Monica, additional, Fontanella, Enrico, additional, Gatti, Laura, additional, Pratesi, Graziella, additional, Fabbri, Alessandra, additional, Andriani, Francesca, additional, Tinelli, Stella, additional, Roz, Elena, additional, Caserini, Roberto, additional, Lo Vullo, Salvatore, additional, Camerini, Tiziana, additional, Mariani, Luigi, additional, Delia, Domenico, additional, Calabrò, Elisa, additional, Pastorino, Ugo, additional, and Sozzi, Gabriella, additional

Published
2009
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19. Synergistic Activation upon METand ALKCoamplification Sustains Targeted Therapy in Sarcomatoid Carcinoma, a Deadly Subtype of Lung Cancer

Author

Pelosi, Giuseppe, Gasparini, Patrizia, Conte, Davide, Fabbri, Alessandra, Perrone, Federica, Tamborini, Elena, Pupa, Serenella M., Ciravolo, Valentina, Caserini, Roberto, Rossi, Giulio, Cavazza, Alberto, Papotti, Mauro, Nakatani, Yukio, Maisonneuve, Patrick, Pastorino, Ugo, and Sozzi, Gabriella

Abstract

Genetic alterations suitable for targeted therapy are poorly known issues in pulmonary sarcomatoid carcinoma (PSC), an uncommon and life-threatening family of non–small cell lung cancers.

Published
2016
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20. Highly tumorigenic lung cancer CD133+ cells display stem-like features and are spared by cisplatin treatment.

Author

Bertolini, Giulia, Roz, Luca, Perego, Paola, Tortoreto, Monica, Fontanella, Enrico, Gatti, Laura, Pratesi, Graziella, Fabbric, Alessandra, Andriani, Francesca, Tinelli, Stella, Roz, Elena, Caserini, Roberto, Lo Vull, Salvatore, Camerini, Tiziana, Mariani, Luigi, Delia, Domenico, Calabró, Elisa, Pastorino, Ugo, and Sozzi, Gabriella

Subjects
DRUG resistance in cancer cells, BIOMARKERS, LUNG cancer treatment, GLYCOPROTEINS, STEM cell research, LABORATORY mice, CISPLATIN, XENOGRAFTS, THERAPEUTICS
Abstract

The identification of lung tumor-initiating cells and associated markers maybe useful for optimization of therapeutic approaches and for predictive and prognostic information in lung cancer patients. CD133, a surface glycoprotein linked to organ-specific stem cells, was described as a marker of cancer-initiating cells in different tumor types. Here, we report that a CD133+, epithelialspecific antigen-positive (CD133+ESA+) population is increased in primary nonsmall cell lung cancer (NSCLC) compared with normal lung tissue and has higher tumorigenic potential in SCID mice and expression of genes involved in sternness, adhesion, motility, and drug efflux than the CD133- counterpart. Cisplatin treatment of lung cancer cells in vitro resulted in enrichment of CD133+ fraction both after acute cytotoxic exposure and in cells with stable cisplatin-resistant phenotype. Subpopulations of CD133+ABCG2+ and CD133+CXCR4+ cells were spared by in vivo cisplatin treatment of lung tumor xenografts established from primary tumors. A tendency toward shorter progression-free survival was observed in CD133+ NSCLC patients treated with platinum-containing regimens. Our results indicate that chemoresistant populations with highly tumorigenic and stem-like features are present in lung tumors. The molecular features of these cells may provide the rationale for more specific therapeutic targeting and the definition of predictive factors in clinical management of this lethal disease. [ABSTRACT FROM AUTHOR]

Published
2009
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21. Microenvironment-Modulated Metastatic CD133+/CXCR4+/EpCAM- Lung Cancer-Initiating Cells Sustain Tumor Dissemination and Correlate with Poor Prognosis.

Author

Bertolini, Giulia, D'Amico, Lucia, Moro, Massimo, Landoni, Elena, Perego, Paola, Miceli, Rosalba, Gatti, Laura, Andriani, Francesca, Wong, Donald, Caserini, Roberto, Tortoreto, Monica, Milione, Massimo, Ferracini, Riccardo, Mariani, Luigi, Pastorino, Ugo, Roato, Ilaria, Sozzi, Gabriella, and Roz, Luca

Subjects
*LUNG tumors, *LUNG cancer, *CANCER cells, *PROGNOSIS, *CLINICAL prediction rules
Abstract

Metastasis is the main reason for lung cancer-related mortality, but little is known about specific determinants of successful dissemination from primary tumors and metastasis initiation. Here, we show that CD133+/CXCR4+ cancer-initiating cells (CIC) directly isolated from patient-derived xenografts (PDX) of non-small cell lung cancer are endowed with superior ability to seed and initiate metastasis at distant organs. We additionally report that CXCR4 inhibition successfully prevents the increase of cisplatin-resistant CD133+/CXCR4+ cells in residual tumors and their metastatization. Immunophenotypic analysis of lung tumor cells intravenously injected or spontaneously disseminated to murine lungs demonstrated the survival advantage and increased colonization ability of a specific subset of CD133+/CXCR4+ with reduced expression of epithelial cell adhesion molecule (EpCAM-), which also shows the greatest in vitro invasive potential. We next prove that recovered disseminated cells from lungs of PDX-bearing mice enriched for CD133+/CXCR4+/EpCAM- CICs are highly tumorigenic and metastatic. Importantly, microenvironment stimuli eliciting epithelial-to-mesenchymal transition, including signals from cancer-associated fibroblasts, are able to increase the dissemination potential of lung cancer cells through the generation of the CD133+/CXCR4+/EpCAM- subset. These findings also have correlates in patient samples where disseminating CICs are enriched in metastatic lymph nodes (20-fold, P = 0.006) and their detection in primary tumors is correlated with poor clinical outcome (diseasefree survival: P = 0.03; overall survival: P = 0.05). Overall, these results highlight the importance of specific cellular subsets in the metastatic process, the need for in-depth characterization of disseminating tumor cells, and the potential of therapeutic strategies targeting both primary tumor and tumor-microenvironment interactions. [ABSTRACT FROM AUTHOR]

Published
2015
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