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339 results on '"Caserta, M."'

1. On the efficiency of the new Italian Senate and the role of 5 Stars Movement: Comparison among different possible scenarios by means of a virtual Parliament model

Author

Pluchino, A., Rapisarda, A., Garofalo, C., Spagano, S., and Caserta, M.

Subjects
Physics - Physics and Society, Computer Science - Social and Information Networks
Abstract

The recent 2013 Italian elections are over and the situation that President Napolitano will have to settle soon for the formation of the new government is not the simplest one. After twenty years of bipolarism (more or less effective), where we were accustomed to a tight battle between two great political coalitions, the center-right and center-left, now, in the new Parliament, we have four political formations. But is it really this result, as it would seem to suggest our common sense, the prelude to an inevitable phase of ungovernability? Can a Parliament with changing majorities in Senate to be as efficient as a Parliament with a large majority in both the Houses? In this short note we will try to answer these questions going beyond common sense and analyzing the current political situation by means of a scientific, original and innovative instrument, i.e. an "agent-based simulation". We show that the situation is not so dramatic as it sounds, but it contains within itself potential positive aspects, as long as one makes the most appropriate choices., Comment: 6 pages, 5 figures

Published
2013

2. Accidental Politicians: How Randomly Selected Legislators Can Improve Parliament Efficiency

Author

Pluchino, A., Garofalo, C., Rapisarda, A., Spagano, S., and Caserta, M.

Subjects
Physics - Physics and Society, Condensed Matter - Statistical Mechanics, Computer Science - Social and Information Networks
Abstract

We study a prototypical model of a Parliament with two Parties or two Political Coalitions and we show how the introduction of a variable percentage of randomly selected independent legislators can increase the global efficiency of a Legislature, in terms of both the number of laws passed and the average social welfare obtained. We also analytically find an "efficiency golden rule" which allows to fix the optimal number of legislators to be selected at random after that regular elections have established the relative proportion of the two Parties or Coalitions. These results are in line with both the ancient Greek democratic system and the recent discovery that the adoption of random strategies can improve the efficiency of hierarchical organizations., Comment: 19 pages, 7 figures, new improved and longer version

Published
2011
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3. Quadrato Motor Training (QMT) is associated with DNA methylation changes at DNA repeats: A pilot study

Author

Marson, F, Zampieri, M, Verdone, L, Bacalini, M, Ravaioli, F, Morandi, L, Chiarella, S, Vetriani, V, Venditti, S, Caserta, M, Raffone, A, Ben-Soussan, T, Reale, A, Marson F., Zampieri M., Verdone L., Bacalini M. G., Ravaioli F., Morandi L., Chiarella S. G., Vetriani V., Venditti S., Caserta M., Raffone A., Ben-Soussan T. D., Reale A., Marson, F, Zampieri, M, Verdone, L, Bacalini, M, Ravaioli, F, Morandi, L, Chiarella, S, Vetriani, V, Venditti, S, Caserta, M, Raffone, A, Ben-Soussan, T, Reale, A, Marson F., Zampieri M., Verdone L., Bacalini M. G., Ravaioli F., Morandi L., Chiarella S. G., Vetriani V., Venditti S., Caserta M., Raffone A., Ben-Soussan T. D., and Reale A.

Abstract

The control of non-coding repeated DNA by DNA methylation plays an important role in genomic stability, contributing to health and healthy aging. Mind-body practices can elicit psychophysical wellbeing via epigenetic mechanisms, including DNA methylation. However, in this context the effects of movement meditations have rarely been examined. Consequently, the current study investigates the effects of a specifically structured movement meditation, called the Quadrato Motor Training (QMT) on psychophysical wellbeing and on the methylation level of repeated sequences. An 8-week daily QMT program was administered to healthy women aged 40–60 years and compared with a passive control group matched for gender and age. Psychological well-being was assessed within both groups by using self-reporting scales, including the Meaning in Life Questionnaire [MLQ] and Psychological Wellbeing Scale [PWB]). DNA methylation profiles of repeated sequences (ribosomal DNA, LINE-1 and Alu) were determined in saliva samples by deep-sequencing. In contrast to controls, the QMT group exhibited increased Search for Meaning, decreased Presence of Meaning and increased Positive Relations, suggesting that QMT may lessen the automatic patterns of thinking. In the QMT group, we also found site-specific significant methylation variations in ribosomal DNA and LINE-1 repeats, consistent with increased genome stability. Finally, the correlations found between changes in methylation and psychometric indices (MLQ and PWB) suggest that the observed epigenetic and psychological changes are interrelated. Collectively, the current results indicate that QMT may improve psychophysical health trajectories by influencing the DNA methylation of specific repetitive sequences.

Published
2023

6. Uncommon presentation of Cholesteryl Ester Storage Disease (CESD): Description of a case and genetic characterization by next generation sequencing

Author

Scrimali, C., primary, Brucato, F., additional, Caserta, M., additional, Alletti, M. Gueli, additional, Castana, C., additional, Spina, R., additional, Ingrassia, V., additional, Altieri, G.I., additional, Fayer, F., additional, Noto, D., additional, Misiano, G., additional, Giammanco, A., additional, Barbagallo, C.M., additional, Ganci, A., additional, Piccione, M., additional, Cefalù, A.B., additional, and Averna, M., additional

Published
2022
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8. Enhanced LC-MS/MS spectra matching through multitask neural networks and molecular fingerprints

Author

Valsecchi, C, Baccolo, G, Caserta, M, Barbagallo, M, Gosetti, F, Consonni, V, Ballabio, D, Todeschini, R, Valsecchi, C, Baccolo, G, Caserta, M, Barbagallo, M, Gosetti, F, Consonni, V, Ballabio, D, and Todeschini, R

Subjects
tandem mass spectrometry, fingerprints, neural networks
Abstract

Liquid chromatography tandem mass spectrometry (LC-MS/MS) is routinely used in many clinical applications, including toxicology, drug monitoring, endocrinology, microbiology, and proteomics, thanks to its versatility and effectiveness in the determination of small molecules. The standard approach for analyzing spectral data is the spectral matching that is based on creating a library of annotated spectra against which individual spectrum can be searched for. Building an own spectral library is time-consuming and dependent on the LC-MS/MS instrumentation used, whereas freely available libraries only cover a limited number of molecules. In many cases and especially with newly synthetized substances, the spectrum could not be found in any spectral databases. In-silico fingerprints are binary vectors that, through a hashing algorithm, encode features of molecules. Due to their easy computation and instrument-independence, in-silico fingerprint databases are bigger and more updated than spectral ones. Prediction of molecular fingerprints starting from the LC-MS/MS spectra would consequently assist the match of any target compound under investigation, which would benefit from the increased dimension of fingerprint databases. In this study, we developed a multi-task neural network able to predict molecular fingerprints starting from the LC-MS/MS spectra. We initially collected and pruned around 70’000 MS spectra from available sources (MassBank of North America). For each compound, fingerprints were calculated (MACCS167 keys and Dragon ECFP of 512 bits) and then multi-task feedforward neural networks were trained to predict the binary bits of molecular fingerprints. Models were validated through specific validation protocols and demonstrated to have suitable performances in terms of predictive accuracy (>85% of bits correctly predicted). Thus, the proposed networks can represent a potential approach for the development of a reliable method to enhance matching of MS spectral data to larger molecular databases. Moreover, with respect to recent studies, the proposed model is simple and works with spectra obtained in different experimental conditions.

Published
2021

16. Scientific Proceedings Second International Symposium on Cytostatic Drug Resistance

Author

Hill, Bridget T., Hosking, L. K., McClean, S., Shellard, S. A., Dempke, W. C. M., Whelan, R. D. H., Sehested, M., Friche, E., Demant, E. J. F., Jensen, P. B., Kopnin, B. P., Wolf, B., Seidel, A., Nickelsen, M., Brandt, I., Heinemann, G., Dietel, M., Bremer, S., Hoof, T., Tümmler, B., Broxterman, H. J., Versantvoort, C. H. M., Kuiper, C. M., Feller, N., Schuurhuis, G. J., Lankelma, J., Gupta, S., Tsuruo, T., Kim, C., Gollapudi, S., Bittl, A., Nap, M., Jäger, W., Lathan, B., Lang, N., Raikhlin, N. T., Perevozchikov, A. G., Volodina, J. L., Licht T., Fiebig H. H., Bross K. J., Herrmann F., Mertelsmann R., Bashir, I., Sikora, K., Foster, C. S., Castagna, M., Viacava, P., Cianfrigliao, M., Favati, A., Collecchi, P., Caligo, M. A., Cipollini, G., Bevilacqua, G., Schrenk, D., Gant, T. W., Silverman, J. A., Thorgeirsson, S. S., Harstrick, A., Zhang, Z. G., Schmoll, H. J., Rustum, Y., Mitze, M., Beck, T., Weikel, W., Brumm, C., Knapstein, P. G., McDonald, T., Gardner, P., Kang, N., van der Heyden, S. A. M., Elst, H. J., Stein, U., Jandrig, B., Krause, H., Schmidt-Peter, P., Frege, J., Wunderlich, V., Boven, E., van Kalken, C. K., Pinedo, H. M., Gebauer, W., Fallgren-Gebauer, E., Diete, M., Wagner, T., Müller, M. R., Lennartz, K., Nowrousian, H. R., Seeber, S., Shtil, A. A., Kazarov, A. R., Gudkov, A. V., Stavrovskaya, A. A., Djuraeva, F. H., Stromskaya, T. P., Noller, A., Frese, G., Neumann, M., Wilisch, A., Probst, H., Gekeler, V., Handgretinger, R., Schmidt, H., Muller, C. P., Dopfer, R., Klingebiel, T., Niethammer, D., Weger, S., Diddens, H., Daumiller, E., Bunge, A., Lilischkis, R., Salmassi, A., Kopun M., Scherthan H., Granzow C., Leuschner, I., Schmidt, D., Hoffmann, H., Harms, D., Scagliotli, G. V., Leonardo, E., Cappia, S., Esposito, G., Tombesi, M., Cianfriglia, M., Esposito, G. V., Merendino, N., Viora, M., Caserta, M., Tritarelli, E., Rocca, E., Boccoli, G., Samoggia, P., Fossati, C., Testa, U., Peschle, C., Darling, J. L., Ashmore, S. M., Peterson, D. C., Thomas, D. G. T., Kramer, R. A., Stanlunas, R., Summerhayes, T., Lion, T., Shoemaker, R. H., Wu, L., Smythe, A., Boyd, M. R., Beck, W. T., Danks, M. K., Wolverton, J. S., Chen, M., Bugg, B. Y., Suttle, D. P., Catapano, C. V., Fernandes, D. J., Gieseler, F., Boege, F., Erttmann, R., Arps, H., Zwelling, L., Wilms, K., Biersack, H., Kaspers, G. J. L., Pieters, R., Klumper, E., de Waal, F. C., van Wering, E. R., Veerman, A. J. P., Schmidt, C. A., Lorenz, F., Schäfer, A., Kirsch, A., Siegert, W., Huhn, D., Simon, W. E., Siebert, G., Schneider, M., Oettling, M., Reymann, A., Entmann, R., Schmidt, S., Woermann, C., Windmeier, C., Herzig, I., Schaefer, B., Heidebrecht, H. J., Wacker, H. H., Künnemann, H., van Heijningen, Th. H. M., Slovak, M. L., Baak, J. P. A., Steidtmann, K., Fichtinger-Schepman, A. -M. J., Hill, B. I., Scanlon, K. J., Zeller, W. J., Chen, G., Gietema, J. A., de Vries, E. G. E, Sleijfer, D.Th, Willemse, P. H. B., Guchelaar, H. J., Uges, D. R. A., Aulenbacher, P., Voegeli, R., Mulder, N. H., Skrezek, C., Bertermann, H., Eichholtz-Wirth, H., Born, R., Bier, H., Koch, M., Bernhardt, G., Hählen, K., Reile, H., van Zantwijk, C. H., Wering, E. R. van, Görögh, T., Lippert, B., Werner, J. A., Eickbohm, J. E., Mickiseh, G. H., Gottesman, M. M., Pastan, I., Hofmann, J., Wolf, A., Spitaler, M., Bock, G., Grunicke, H., Ponstingl, H., Roth, I., Granzow, C., Dörner, C., Erttmann, R., Looft, G., Ossenkoppele, G. J., Scheffer, G. L., Atassi, G., Pierre, A., Kraus, L., Leonce, S., Regnier, G., Dhainaut, A., Ponstingl H., Stöhr M., Rohlff, C., Glazer, R. I., Cho-Chung, Y. S., Höllt, V., Kouba, M., Vogt, G., Allmeier, H., Nissen, N. I., Cros, S., Guilbaud, N., Dunn, T., Berlion, M., Atassi, G., Bizzari, J. P., Messing, A. M., Matuschek, A., Mutter, I., Kiwit, J. C. W., Bastian, L., Goretzki, P. E., Frilling, A., Simon, D., Röher, H. D., Reichle, A., Altmayr, F., Rastetter, J., Erbil, C., Jaques, G., Maasberg, M., Havemann, K., Häußermann, K., Heidebrecht, H. -J., Van de Vrie, W., Gheuens, E. E. O., Durante, N. M. C., De Bruijn, E. A., Marquet, R. L., Van Oosterom, A. T., Eggermont, A. M. M., Stow, M. W., Vickers, S. E., Warr, J. R., Roller, E., Eichelbaum, M., Klumpp, B., Krause, J., Schumacher, K., Hörner, S., Laßmann, A., Traugott, U., Schlick, E., Bürkle, D., Futscher BW, List AF, Dalton WS, Ladda, E., Bühl, K., Weimer, A., Eser, C., Hamprecht, K., Schalk, K. P., Jackisch, C., Brandt, B., Blum, M., Louwen, F., Schulz, K., Hanker, J. P., Rüther, U., Schmidt, A., Müller, H. A. G., Nunnensiek, C., Bader, H., Eisenberger, F., Jipp, P., Niethammer, B., Muller, C., Ling, V., Joncourt, F., Redmond, S., Stöhr, M., Buser, K., Fey, M., Tobler, A., Brunner, K., Gratwohl, A., Cerrry, T., Nuessler, V., Pelka-Fleischer, R., Nerl, C., Beckert, B., Wilmanns, W., Hegewisch-Becker, S., Fliegner, M., Zander, A., Hossfeld, D. K., Blanz, J., Mewes, K., Ehninger, G., Zeller, K. -P., Schuldes, H., Herrmann, G., Boeckmann, W., Schroeder, R., Jonas, D., Zurborn, K. -H., Bruhn, H. D., Uharek, L., Glass, B., Gassmann, W., Loeffler, H., Mueller-Ruohholtz, W., Gassmann W., Glass B., Uharek L., Loeffler H., Mueller-Ruchholtz W., Jaquet, K., Kreipe, H., Felgner, J., Radzun, H. J., Parwaresch, M. R., Kogan EA, Mazurenko NN, Sekamova SM, Wolf, H., Röhe, K., Wilkens, K., Clausen, M., Henze, E., van der Bosch, J., Rüller, S., Schlaak, M., Köhl, U., Schwabe, D., Rohrbach, E., Montag, E., Bauer, S., Cinatl, J., Cinatl, Jr, I., Mainke, M., Geiss, H., Kornhuber, B., Juhl, H., Stritzel, H., Kalhoff, H., Schniegel, W., Menke, T., Pröbsting, B., Schulze-Westhoff, P., Boos, J., Weidner, J., Wedemeyer, N., Wiedorn, K., Ueda, Y., Blasius, S., Wuisman, P., Böcker, W., Roessner, A., Dockhorn-Dworniczak, B., Ramm, D., Knebel, J., Sass, W., Aufderheide, M., and Seifert, J.

Published
1991
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20. Miositi dell'età pediatrica: Analisi di una casistica biennale

Author

TRICARICO, Alessandra, ALGA, Paola, FERRANTE, Giuliana, ACCOMANDO, Salvatore, CORSELLO, Giovanni, Caserta, M, Castana, C, Mortillaro, A, Tricarico, A, Alga, P, Ferrante, G, Accomando, S, Caserta, M, Castana, C, Mortillaro, A, and Corsello, G

Subjects
Settore MED/38 - Pediatria Generale E Specialistica, BACM, MME
Published
2015

21. Outreach and Mission Drift in Microfinance: An Interpretation of the New Trend

Author

Reito, Francesco and Caserta, M.

Subjects
Individual liability lending, joint liability lending, mission drift, Individual liability lending, joint liability lending, outreach, mission drift, for-profit microfinance institutions, jel:O1, jel:D8
Abstract

This paper presents a theoretical description of some of the recent developments in the financial programs offered by microfinance institutions (MFIs). We show that even under for-profit MFIs, there is not necessarily a crowding out of the poorest microentrepreneurs, and that MFIs may optimally choose to offer both joint liability contracts (to poor borrowers) and individual liability contracts (to wealthier borrowers).

Published
2013

27. Production scale and product markets: the Sicilian wine sector case

Author

Caserta M., Musumeci M., and Consoli A.

Subjects
Wine Sector, Production Scale, External Markets, R11, R12
Abstract

Accessing new markets generally depends on the ability of firms to be competitive in those markets. Therefore, low scale production - and the correlated narrowness of markets - often depends on the inability of firms to leave a protected area. In fact, leaving a protected area requires competing with firms outside that area. If that competition is unsustainable, firms will be confined within that protected area.Price and quality are two traditional areas of competition. In both cases competitiveness requires to act on costs. Since cost structure often depends on scale, it turns out that it is precisely scale one of the fundamental factors expected to have an impact on the ability of firms to extend their markets. An increasing production scale, therefore, enables firms to consider extending their markets outside protected areas. It is likely, however, that this will not happen in a linear way. It is only after a particular production scale has been attained that more distant markets can be reached. It is the scale associated to the standard costs prevailing in outside markets, both national and international. It follows that the enlargement of the internal market is a crucial requirement for growing outside regional or national boundaries. After having described the structure and degree of development of wine firms in Sicily, this paper will aim at checking whether a causal connection can exist between their scale production and their ability to expand towards new product markets.

Published
2010
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30. Autoimmune thyroiditis and phenilketonuria: a new association

Author

CORSELLO, Giovanni, MAGGIO, Maria Cristina, Caserta, M, Castana, C, Mortillaro, A, Bertelloni, S, Corsello, G, Caserta, M, Castana, C, Mortillaro, A, Bertelloni, S, and Maggio, MC

Subjects
Settore MED/38 - Pediatria Generale E Specialistica, PHENILKETONURIA, AUTOIMMUNE THYROIDITIS
Published
2011

31. Increased creativity and proNGF decrease following Quadrato Motor Training

Author

Venditti S, Verdone L, Pesce C, Tocci T, Caserta M, and Ben-Soussan TD

Subjects
proNGF Quadrato Motor Training creativity
Abstract

Mind-body practices (MBP) are known to induce electrophysiological and morphological changes, whereas reports related to changes of neurotrophins are surprisingly scarce. Consequently, in the current paper, we focused on the Quadrato motor training (QMT), a newly developed whole-body movement-basedMBP, which has been reported to enhance creativity. Here we report the effects of 4 weeks of daily QMT on creativity and proNGF level in two interrelated studies. In Study A, we examined the effects of QMT compared with a walking training (WT) in healthy adults, utilizing the alternate uses task. In contrast with the WT, QMT resulted in increased creativity. In addition, the change in creativity negatively correlated with the change in proNGF levels. In Study B, we examined QMT effects on creativity and additional metacognitive functions in children, using a nonintervention group as control. Similar to Study A, following QMT, we found a negative correlation of proNGF with creativity, as well as working memory updating and planning ability. Together, the current results point to the relationship between increased creativity and decreased proNGF following MBP.Thus, the current research emphasizes the importance of widening the scope of examination of "MBP in motion" in relation to metacognition and well-being.

Published
2015
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32. Poly(ADP-Ribosyl)ation Affects Histone Acetylation and Transcription

Author

Verdone L 1, La Fortezza M 2, Ciccarone F 3, 4, Caiafa P 3, Zampieri M 3, and Caserta M 1.

Subjects
epigenetic cross-talk, gene expression, H3/H4 acetylation, Poly(ADP-ribosyl)ation, PARP
Abstract

Poly(ADP-ribosyl)ation (PARylation) is a posttranslational protein modification catalyzed by members of the poly(ADP-ribose) polymerase (PARP) enzyme family. PARylation regulates a wide variety of biological processes in most eukaryotic cells including energy metabolism and cell death, maintenance of genomic stability, chromatin structure and transcription. Inside the nucleus, cross-talk between PARylation and other epigenetic modifications, such as DNA and histone methylation, was already described. In the present work, using PJ34 or ABT888 to inhibit PARP activity or over-expressing poly(ADP-ribose) glycohydrolase (PARG), we show decrease of global histone H3 and H4 acetylation. This effect is accompanied by a reduction of the steady state mRNA level of p300, Pcaf, and Tnf?, but not of Dnmt1. Chromatin immunoprecipitation (ChIP) analyses, performed at the level of the Transcription Start Site (TSS) of these four genes, reveal that changes in histone acetylation are specific for each promoter. Finally, we demonstrate an increase of global deacetylase activity in nuclear extracts from cells treated with PJ34, whereas global acetyltransferase activity is not affected, suggesting a role for PARP in the inhibition of histone deacetylases. Taken together, these results show an important link between PARylation and histone acetylation regulated transcription.

Published
2015
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33. Randomized study of traditional versus aggressive systolic blood pressure control (Cardio-Sis): rationale, design and characteristics of the study population. Cardio-Sis Study Group

Author

Verdecchia P, Staessen JA, Achilli A, DE SIMONE, GIOVANNI, Ganau A, Mureddu G, Pede S, Porcellati C, Fornari G, Repaci S, Castellani C, Achilli P, Jaspers C, Cucchiara G, Panzano C, Angeli F, Aillon C, Sclavo MG, Scherillo M, Raucci D, Di Donato M, Cas LD, Faggiano P, Porcu M, Calamida R, Pistia L, Vancheri F, Alletto M, Curcio M, Pettinati G, Ieva M, Muscella A, Guerrieri M, Denbek C, Gulizia M, Francese GM, Perticone F, Iemma G, Fariello R, Sala N, Mezzetti A, Pierdomenico SD, Bucci M, Benemio G, Gattobigio R, Sacchi N, Cocchieri M, Prosciutti L, Battocchi P, Garognoli O, Arcelli G, Pirelli S, Emanuelli C, Braschi GB, Abrignani M, De Ferrari G, Ponremoli R, Igidbashian D, Marini R, Scarpino L, Mandorla S, Buccolieri M, Picchi L, Casolo G, Pardini M, Marracci G, STRAZZULLO, PASQUALE, GALLETTI, FERRUCCIO, BARBATO, ANTONIO, Cavallini C, Borgioni C, Seghieri G, Cipollini F, Arcangeli E, Boddi W, Palermo C, Savelli F, Lembo G, Vecchione C, Malatino L, Belluardo P, Zoccali C, Leonardis D, Mallamaci F, Lacchè A, Gentile C, Boccanelli A, Mureddu GF, Santini M, Colivicchi F, Ficili S, Uguccioni M, Nardozi C, Tedeschi A, Martin G, Zanata G, Mos L, Dialti V, Martina S, Renna A, Farina G, Tripodi E, Miserrafiti B, Scali R, Stornello M, Valvo E, Bernardinangeli M, Proietti G, Poddighe G, Biscottini B, Panciarola R, Boccali A, Veglio F, Rabbia F, Caserta M, Chiatto M, Stefenelli C, Cioffi G, Bonazza G, Scabbia EV, Bottoni D., Verdecchia, P, Staessen, Ja, Achilli, A, DE SIMONE, Giovanni, Ganau, A, Mureddu, G, Pede, S, Porcellati, C, Fornari, G, Repaci, S, Castellani, C, Achilli, P, Jaspers, C, Cucchiara, G, Panzano, C, Angeli, F, Aillon, C, Sclavo, Mg, Scherillo, M, Raucci, D, Di Donato, M, Cas, Ld, Faggiano, P, Porcu, M, Calamida, R, Pistia, L, Vancheri, F, Alletto, M, Curcio, M, Pettinati, G, Ieva, M, Muscella, A, Guerrieri, M, Denbek, C, Gulizia, M, Francese, Gm, Perticone, F, Iemma, G, Fariello, R, Sala, N, Mezzetti, A, Pierdomenico, Sd, Bucci, M, Benemio, G, Gattobigio, R, Sacchi, N, Cocchieri, M, Prosciutti, L, Battocchi, P, Garognoli, O, Arcelli, G, Pirelli, S, Emanuelli, C, Braschi, Gb, Abrignani, M, De Ferrari, G, Ponremoli, R, Igidbashian, D, Marini, R, Scarpino, L, Mandorla, S, Buccolieri, M, Picchi, L, Casolo, G, Pardini, M, Marracci, G, Strazzullo, Pasquale, Galletti, Ferruccio, Barbato, Antonio, Cavallini, C, Borgioni, C, Seghieri, G, Cipollini, F, Arcangeli, E, Boddi, W, Palermo, C, Savelli, F, Lembo, G, Vecchione, C, Malatino, L, Belluardo, P, Zoccali, C, Leonardis, D, Mallamaci, F, Lacchè, A, Gentile, C, Boccanelli, A, Mureddu, Gf, Santini, M, Colivicchi, F, Ficili, S, Uguccioni, M, Nardozi, C, Tedeschi, A, Martin, G, Zanata, G, Mos, L, Dialti, V, Martina, S, Renna, A, Farina, G, Tripodi, E, Miserrafiti, B, Scali, R, Stornello, M, Valvo, E, Bernardinangeli, M, Proietti, G, Poddighe, G, Biscottini, B, Panciarola, R, Boccali, A, Veglio, F, Rabbia, F, Caserta, M, Chiatto, M, Stefenelli, C, Cioffi, G, Bonazza, G, Scabbia, Ev, and Bottoni, D.

Abstract

The hypothesis that a therapeutic strategy aimed at lowering systolic blood pressure (SBP) below 130 mm Hg is superior to a conventional strategy targeted at below 140 mm Hg in hypertensive subjects has never been tested in randomized intervention studies. The Studio Italiano Sugli Effetti Cardiovascolari del Controllo della Pressione Arteriosa Sistolica (Cardio-Sis) is a multi-centre study in non-diabetic, treated hypertensive subjects aged >55 years with uncontrolled SBP (>or=150 mm Hg) and at least one additional cardiovascular risk factor (ClinicalTrials.gov identifier: NCT00421863). Subjects are randomized to an SBP goal

Published
2008

36. The molecular side of Quadrato

Author

Venditti, Sabrina Donatella Sonia, Verdone, L., Dotan Ben Soussan, T., and Caserta, M.

Subjects
Neurotrophins, Mind body practices, Quadrato Motor Training
Published
2013

37. L'efficienza del caso

Author

Pluchino, Alessandro, Rapisarda, Andrea, Garofalo, C, Spagano, Salvatore, and Caserta, M.

Subjects
sistemi complessi, caso, efficienza, Parlamento, Sociofisica
Published
2013

41. Democrazia a Sorte

Author

Caserta, M, Garofalo, C, Pluchino, Alessandro, Rapisarda, Andrea, and Spagano, S.

Subjects
sociofisica, caso, simulazioni ad agenti, sistemi complessi, complessità
Published
2012

42. A pool-based pattern generation algorithm for logical analysis of data with automatic fine-tuning

Author

Caserta, M., Reiners, Torsten, Caserta, M., and Reiners, Torsten

Abstract

In this paper, we address the binary classification problem, in which one is given a set of observations, characterized by a number of (binary and non-binary) attributes and wants to determine which class each observation belongs to. The proposed classification algorithm is based on the Logical Analysis of Data (LAD) technique and belongs to the class of supervised learning algorithms. We introduce a novel metaheuristic-based approach for pattern generation within LAD. The key idea relies on the generation of a pool of patterns for each given observation of the training set. Such a pool is built with one or more criteria in mind (e.g., diversity, homogeneity, coverage, etc.), and is paramount in the achievement of high classification accuracy, as shown by the computational results we obtained. In addition, we address one of the major concerns of many data mining algorithms, i.e., the fine-tuning and calibration of parameters. We employ here a novel technique, called biased Random-Key Genetic Algorithm that allows the calibration of all the parameters of the algorithm in an automatic fashion, hence reducing the fine-tuning effort required and enhancing the performance of the algorithm itself. We tested the proposed approach on 10 benchmark instances from the UCI repository and we proved that the algorithm is competitive, both in terms of classification accuracy and running time.

Published
2015

43. A phase II study on the efficacy and safety of procedural analgesia with fentanyl buccal tablet in cancer patients for the placement of indwelling central venous access systems

Author

Bortolussi, R, primary, Zotti, P, additional, Matovic, M, additional, Morabito, A, additional, Bertuzzi, C, additional, Caserta, M, additional, Fabiani, F, additional, Fracasso, A, additional, Santantonio, C, additional, Zanier, C, additional, Roscetti, A, additional, Polesel, J, additional, Gussetti, D, additional, Bedin, S, additional, Colussi, AM, additional, and Fantin, D, additional

Published
2015
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49. Randomized study of traditional versus aggressive systolic blood pressure control (Cardio-Sis): rationale, design and characteristics of the study population

Author

VERDECCHIA P, CARDIO SIS STUDY G. R. O. U. P., Staessen, Ja, Achilli, A, DE SIMONE, G, Ganau, A, Mureddu, G, Pede, S, Porcellati, C, Fornari, G, Repaci, S, Castellani, C, Achilli, P, Jaspers, C, Cucchiara, G, Panzano, C, Angeli, F, Aillon, C, Sclavo, Mg, Scherillo, M, Raucci, D, DI DONATO, M, Cas, Ld, Faggiano, P, Porcu, M, Calamida, R, Pistia, L, Vancheri, F, Alletto, M, Curcio, M, Pettinati, G, Ieva, M, Muscella, A, Guerrieri, M, Denbek, C, Gulizia, M, Francese, Gm, Perticone, F, Iemma, G, Fariello, R, Sala, N, Mezzetti, A, Pierdomenico, Sd, Bucci, M, Benemio, G, Gattobigio, R, Sacchi, N, Cocchieri, M, Prosciutti, L, Battocchi, P, Garognoli, O, Arcelli, G, Pirelli, S, Emanuelli, C, Braschi, Gb, Abrignani, M, DE FERRARI, G, Ponremoli, R, Igidbashian, D, Marini, R, Scarpino, L, Mandorla, S, Buccolieri, M, Picchi, L, Casolo, G, Pardini, M, Marracci, G, Strazzullo, P, Galletti, F, Barbato, A, Cavallini, C, Borgioni, C, Seghieri, G, Cipollini, F, Arcangeli, E, Boddi, W, Palermo, C, Savelli, F, Lembo, G, Vecchione, C, Malatino, Lorenzo, Belluardo, P, Zoccali, C, Leonerdis, D, Mallamaci, F, Lacchè, A, Gentile, C, Boccanelli, A, Mureddu, Gf, Santini, M, Colivicchi, F, Ficili, S, Uguccioni, M, Nardozi, C, Tedeschi, A, Martin, G, Zanata, G, Mos, L, Dialti, V, Martina, S, Renna, A, Farina, G, Tripodi, E, Miserrafiti, B, Scali, R, Stornello, M, Valvo, E, Bernardinangeli, M, Proietti, G, Poddighe, G, Biscottini, B, Panciarola, R, Boccali, A, Veglio, F, Rabbia, F, Caserta, M, Chiatto, M, Stefenelli, C, Cioffi, G, Bonazza, G, Scabbia, Ev, and Bottoni, D.

Published
2008

50. Randomized study of traditional versus aggressive systolic blood pressure control (Cardio-Sis): rationale, design and characteristics of the study population

Author

Cardio Sis Study Group, Verdecchia, P, Staessen, Ja, Achilli, A, de Simone, G, Ganau, A, Mureddu, G, Pede, S, Porcellati, C, Fornari, G, Repaci, S, Castellani, C, Achilli, P, Jaspers, C, Cucchiara, G, Panzano, C, Angeli, F, Aillon, C, Sclavo, Mg, Scherillo, M, Raucci, D, Di Donato, M, DEI CAS, Livio, Faggiano, P, Porcu, M, Calamida, R, Pistia, L, Vancheri, F, Alletto, M, Curcio, M, Pettinati, G, Ieva, M, Muscella, A, Guerrieri, M, Denbek, C, Gulizia, M, Francese, Gm, Perticone, F, Iemma, G, Fariello, R, Sala, N, Mezzetti, A, Pierdomenico, Sd, Bucci, M, Benemio, G, Gattobigio, R, Sacchi, N, Cocchieri, M, Prosciutti, L, Battocchi, P, Garognoli, O, Arcelli, G, Pirelli, S, Emanuelli, C, Braschi, Gb, Abrignani, M, De Ferrari, G, Ponremoli, R, Igidbashian, D, Marini, R, Scarpino, L, Mandorla, S, Buccolieri, M, Picchi, L, Casolo, G, Pardini, M, Marracci, G, Strazzullo, P, Galletti, F, Barbato, A, Cavallini, C, Borgioni, C, Seghieri, G, Cipollini, F, Arcangeli, E, Boddi, W, Palermo, C, Savelli, F, Lembo, G, Vecchione, C, Malatino, L, Belluardo, P, Zoccali, C, Leonardis, D, Mallamaci, F, Lacchè, A, Gentile, C, Boccanelli, A, Mureddu, Gf, Santini, M, Colivicchi, F, Ficili, S, Uguccioni, M, Nardozi, C, Tedeschi, A, Martin, G, Zanata, G, Mos, L, Dialti, V, Martina, S, Renna, A, Farina, G, Tripodi, E, Miserrafiti, B, Scali, R, Stornello, M, Valvo, E, Bernardinangeli, M, Proietti, G, Poddighe, G, Biscottini, B, Panciarola, R, Boccali, A, Veglio, F, Rabbia, F, Caserta, M, Chiatto, M, Stefenelli, C, Cioffi, G, Bonazza, G, Scabbia, Ev, and Bottoni, D.

Published
2008

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