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10. Modeling Co-treatment of Leachate in Municipal Wastewater Treatment Plants in the Context of Dynamic Loads and Energy Prices

Author

Dereli, Recep Kaan, Giberti, Matteo, Liu, Qipeng, Casey, Eoin, Pisello, Anna Laura, Editorial Board Member, Hawkes, Dean, Editorial Board Member, Bougdah, Hocine, Editorial Board Member, Rosso, Federica, Editorial Board Member, Abdalla, Hassan, Editorial Board Member, Boemi, Sofia-Natalia, Editorial Board Member, Mohareb, Nabil, Editorial Board Member, Mesbah Elkaffas, Saleh, Editorial Board Member, Bozonnet, Emmanuel, Editorial Board Member, Pignatta, Gloria, Editorial Board Member, Mahgoub, Yasser, Editorial Board Member, De Bonis, Luciano, Editorial Board Member, Kostopoulou, Stella, Editorial Board Member, Pradhan, Biswajeet, Editorial Board Member, Abdul Mannan, Md., Editorial Board Member, Alalouch, Chaham, Editorial Board Member, O. Gawad, Iman, Editorial Board Member, Amer, Mourad, Series Editor, Naddeo, Vincenzo, editor, Balakrishnan, Malini, editor, and Choo, Kwang-Ho, editor

Published
2020
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14. Modelling Demand and Response in WWTPs: Extension of BSM1 with Aeration Tank Settling

Author

Giberti, Matteo, Dereli, Recep Kaan, Flynn, Damian, Casey, Eoin, Pisello, Anna Laura, Editorial Board Member, Hawkes, Dean, Editorial Board Member, Bougdah, Hocine, Editorial Board Member, Rosso, Federica, Editorial Board Member, Abdalla, Hassan, Editorial Board Member, Boemi, Sofia-Natalia, Editorial Board Member, Mohareb, Nabil, Editorial Board Member, Mesbah Elkaffas, Saleh, Editorial Board Member, Bozonnet, Emmanuel, Editorial Board Member, Pignatta, Gloria, Editorial Board Member, Mahgoub, Yasser, Editorial Board Member, De Bonis, Luciano, Editorial Board Member, Kostopoulou, Stella, Editorial Board Member, Pradhan, Biswajeet, Editorial Board Member, Abdul Mannan, Md., Editorial Board Member, Alalouch, Chaham, Editorial Board Member, O. Gawad, Iman, Editorial Board Member, Amer, Mourad, Series Editor, Naddeo, Vincenzo, editor, Balakrishnan, Malini, editor, and Choo, Kwang-Ho, editor

Published
2020
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48. Additional file 1 of Synthesis and self-assembly of curcumin-modified amphiphilic polymeric micelles with antibacterial activity

Author

Barros, Caio H. N., Dishon W. Hiebner, Fulaz, Stephanie, Vitale, Stefania, Quinn, Laura, and Casey, Eoin

Abstract

Additional file 1: Figure S1. FTIR spectra of dextran, PLGA-COOH and PLGA-Dex10 copolymer. Carbonyl stretching band from PLGA-COOH is maintained in PLGA-Dex10. Band derived from O-H stretching is also maintained from dextran to PLGA-Dex10. Bands in the region between 1600 cm-1 to 1000 cm-1 in the spectrum of PLGA-COOH had their intensities decreased in the spectrum of PLGA-Dex10 possibly due to a concentration effect, as dextran is also abundant in the copolymer. Figure S2. FTIR of micelles. Bands derived from curcumin such as C-O bending and C-O stretching (phenol) are conserved in the spectrum of PLGA-Dex10-curc, thus confirming the incorporation of the compound in the micelle’s structure. Table S1. Infrared absorption bands assignment of micelles. Figure S3. CLSM images of GFP-expressing P. putida (A), PLGA-Dex10-curc micelles (B), the merged image generated with both P. putida and micelles (C) and inset of an area displaying bleedthrough between channels, seen as yellow spots which cannot be assigned correctly to either bacteria or micelles (D).

Published
2021
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49. Enzyme-Functionalized Mesoporous Silica Nanoparticles to Target Staphylococcus aureus and Disperse Biofilms

Author

Devlin,Henry, Fulaz,Stephanie, Hiebner,Dishon Wayne, O'Gara,James P, Casey,Eoin, Devlin,Henry, Fulaz,Stephanie, Hiebner,Dishon Wayne, O'Gara,James P, and Casey,Eoin

Abstract

Henry Devlin,1,* Stephanie Fulaz,1,* Dishon Wayne Hiebner,1 James P O’Gara,2 Eoin Casey1 1UCD School of Chemical and Bioprocess Engineering, University College Dublin, Dublin, Ireland; 2Department of Microbiology, School of Natural Sciences, National University of Ireland, Galway, Ireland*These authors contributed equally to this workCorrespondence: Eoin CaseyUCD School of Chemical and Bioprocess Engineering, University College Dublin, Belfield, Dublin, IrelandEmail eoin.casey@ucd.ieBackground: Staphylococcus aureus biofilms pose a unique challenge in healthcare due to their tolerance to a wide range of antimicrobial agents. The high cost and lengthy timeline to develop novel therapeutic agents have pushed researchers to investigate the use of nanomaterials to deliver antibiofilm agents and target biofilm infections more efficiently. Previous studies have concentrated on improving the efficacy of antibiotics by deploying nanoparticles as nanocarriers. However, the dispersal of the extracellular polymeric substance (EPS) matrix in biofilm-associated infections is also critical to the development of novel nanoparticle-based therapies.Methods: This study evaluated the efficacy of enzyme-functionalized mesoporous silica nanoparticles (MSNs) against methicillin-resistant S. aureus (MRSA) and methicillin-sensitive S. aureus (MSSA) biofilms. MSNs were functionalized with the enzyme lysostaphin, which causes cell lysis of S. aureus bacteria. This was combined with two other enzyme functionalized MSNs, serrapeptase and DNase I which will degrade protein and eDNA in the EPS matrix, to enhance eradication of the biofilm. Cell viability after treatment with enzyme-functionalized MSNs was assessed using a MTT assay and CLSM, while crystal violet staining was used to assess EPS removal.Results: The efficacy of all three enzymes against S. aureus cells and biofilms was significantly improved when they were immobilized onto MSNs. Treatment efficacy was further enhanced wh

Published
2021

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