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448 results on '"Cassidy, Aedín"'

14. A combined DHA-rich fish oil and cocoa flavanols intervention does not improve cognition or brain structure in older adults with memory complaints: results from the CANN randomized, controlled parallel-design study

Author

Vauzour, David, Scholey, Andrew, White, David J, Cohen, Neal J, Cassidy, Aedín, Gillings, Rachel, Irvine, Michael A, Kay, Colin D, Kim, Min, King, Rebecca, Legido-Quigley, Cristina, Potter, John F, Schwarb, Hilary, and Minihane, Anne-Marie

Published
2023
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20. The state of the science on the health benefits of blueberries: a perspective

Author

Stull, April J., primary, Cassidy, Aedín, additional, Djousse, Luc, additional, Johnson, Sarah A., additional, Krikorian, Robert, additional, Lampe, Johanna W., additional, Mukamal, Kenneth J., additional, Nieman, David C., additional, Porter Starr, Kathryn N., additional, Rasmussen, Heather, additional, Rimm, Eric B., additional, Stote, Kim S., additional, and Tangney, Christy, additional

Published
2024
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33. Flavonoid intakes, chronic obstructive pulmonary disease, adult asthma, and lung function: A cohort study in the UK Biobank

Author

Bondonno, Nicola P., Parmenter, Benjamin H., Thompson, Alysha S., Jennings, Amy, Murray, Kevin, Rasmussen, Daniel Bech, Tresserra-Rimbau, Anna, Kühn, Tilman, Cassidy, Aedín, Bondonno, Nicola P., Parmenter, Benjamin H., Thompson, Alysha S., Jennings, Amy, Murray, Kevin, Rasmussen, Daniel Bech, Tresserra-Rimbau, Anna, Kühn, Tilman, and Cassidy, Aedín

Abstract

Background: Given their antioxidative stress, anti-allergic, anti-inflammatory, and immune-modulating effects, flavonoids are hypothesized to play a role in preventing chronic obstructive pulmonary disease (COPD) and asthma. Objectives: This cohort study aimed to examine associations between flavonoid intake and COPD, asthma, and lung function. Methods: Among 119,466 participants of the UK Biobank, median [interquartile range] age of 60 [53, 65] y, we estimated intakes of flavonoids, flavonoid-rich foods, and a flavodiet score from 24-h diet assessments. Prospective associations with both incident COPD and asthma and cross-sectional associations with measures of lung function [%predicted forced expiratory volume in 1s (FEV1); and FEV1/forced vital capacity (FVC)] were examined using multivariable-adjusted Cox proportional hazards and linear regression models, respectively. We investigated mediation by inflammation––represented by the INFLA score––and stratified analyses by smoking status. Results: Compared with low intakes, moderate intakes of total flavonoids, flavonols, theaflavins + thearubigins, and flavanones, and moderate-to-high intakes of flavanol monomers, proanthocyanidins, anthocyanins, flavones, and the flavodiet score were associated with up to an 18% lower risk of incident COPD {e.g., [hazard ratio (95% confidence interval) for total flavonoids: 0.83 (0.75, 0.92)]} but not incident asthma. Furthermore, compared with low intakes, higher intakes of all flavonoid subclasses (except theaflavins + thearubigins), and the flavodiet score were associated with better percent predicted FEV1 baseline. Associations were most apparent in ever (current or former) smokers. Flavonoid intakes were inversely associated with the INFLA score, which appeared to mediate 11%–14% of the association between intakes of proanthocyanidins and flavones and incident COPD. Conclusions: Moderate-to-high flavonoid intakes were associated with a lower risk of COPD and better lung funct

Published
2024

34. Flavonoid-rich foods, dementia risk, and interactions with genetic risk, hypertension, and depression

Author

Jennings, Amy, Thompson, Alysha S., Tresserra-Rimbau, Anna, O'Neill, Joshua K., Hill, Claire, Bondonno, Nicola P., Kühn, Tilman, Cassidy, Aedín, Jennings, Amy, Thompson, Alysha S., Tresserra-Rimbau, Anna, O'Neill, Joshua K., Hill, Claire, Bondonno, Nicola P., Kühn, Tilman, and Cassidy, Aedín

Abstract

Importance: A composite score of flavonoid-rich foods (flavodiet) may provide a clear public health message regarding the range of foods with the potential to lower dementia risk. Objective: To examine associations of flavodiet score and intakes of flavonoid subclasses with dementia risk according to genetic risk and presence of depression and hypertension. Design, Setting, and Participants: This prospective, population-based cohort study included dietary data from adults aged 40 to 70 years in the UK Biobank, recruited between 2006 and 2010, with a mean (SD) follow-up of 9.2 (1.5) years. The data analyses were conducted from September 1 to 30, 2023. Exposure: Flavodiet score adherence and intake of flavonoid subclasses derived from 24-hour computerized dietary assessments. Main Outcome and Measures: The main outcome was incident all-cause dementia and interactions with genetic risk, hypertension, and depressive symptoms using multivariable Cox proportional hazards regression models. Results: The sample included 121 986 participants (mean [SD] age, 56.1 [7.8] years; 55.6% female; 882 with incident dementia). Comparing the highest with lowest quintile of flavodiet score, consuming 6 additional servings per day of flavonoid-rich foods was associated with a lower risk of dementia among all participants (adjusted hazard ratio [AHR], 0.72; 95% CI, 0.57-0.89), those at high genetic risk (AHR, 0.57; 95% CI, 0.42-0.78), and those with depressive symptoms (AHR, 0.52; 95% CI, 0.33-0.81) after multivariable adjustment. The greatest risk reduction was observed in participants consuming at least 2 of the following per day: 5 servings of tea, 1 serving of red wine, and 0.5 servings of berries, compared with those who did not achieve any of these intakes (AHR, 0.62; 95% CI, 0.46-0.84). Higher intakes of flavonoid subclasses, including anthocyanins, flavan-3-ols, flavonols, and flavones, of which tea, red wine, and berries are the main contributors, supported these findings, showin

Published
2024

40. A Mediterranean-like dietary pattern with vitamin D3 (10 µg/d) supplements reduced the rate of bone loss in older Europeans with osteoporosis at baseline: results of a 1-y randomized controlled trial

Author

Jennings, Amy, Cashman, Kevin D, Gillings, Rachel, Cassidy, Aedin, Tang, Jonathan, Fraser, William, Dowling, Kirsten G, Hull, George L J, Berendsen, Agnes A M, de Groot, Lisette C P G M, Pietruszka, Barbara, Wierzbicka, Elzbieta, Ostan, Rita, Bazzocchi, Alberto, Battista, Giuseppe, Caumon, Elodie, Meunier, Nathalie, Malpuech-Brugère, Corinne, Franceschi, Claudio, Santoro, Aurelia, and Fairweather-Tait, Susan J

Published
2018
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43. Effects of isoflavones on breast density in pre- and post-menopausal women: a systematic review and meta-analysis of randomized controlled trials

Author

Hooper, Lee, Madhavan, Giri, Tice, Jeffrey A, Leinster, Sam J, and Cassidy, Aedín

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Nutrition, Clinical Trials and Supportive Activities, Breast Cancer, Cancer, Aging, Estrogen, Prevention, Clinical Research, Complementary and Integrative Health, 3.3 Nutrition and chemoprevention, Prevention of disease and conditions, and promotion of well-being, Reproductive health and childbirth, Age Factors, Breast, Breast Neoplasms, Female, Humans, Isoflavones, Mammography, Postmenopause, Randomized Controlled Trials as Topic, Risk Assessment, isoflavone, mammographic density, breast cancer risk, meta-analysis, menopause, Clinical Sciences, Paediatrics and Reproductive Medicine, Public Health and Health Services, Obstetrics & Reproductive Medicine, Reproductive medicine
Abstract

BackgroundIsoflavones from soy and red clover exert modest hormonal effects in women, but the relevance to risk of breast cancer is unclear. The aim of this meta-analysis was to assess the effects of isoflavone-rich foods or supplements on a biomarker of breast cancer risk, women's mammographic density.MethodsElectronic searches were performed on The Cochrane Library, Medline and EMBASE (to June 2009), and reference lists and trial investigators were consulted to identify further studies. Randomized controlled trials (RCTs) of isoflavone-rich foods or supplements versus placebo with a duration of at least 6 months were included in our analysis. Inclusion/exclusion, data extraction and validity assessment were carried out independently in duplicate, and meta-analysis used to pool study results. Subgrouping, sensitivity analysis, assessment of heterogeneity and funnel plots were used to interpret the results.ResultsEight RCTs (1287 women) compared isoflavones with placebo for between 6 months and 3 years. Meta-analysis suggested no overall effect of dietary isoflavones on breast density in all women combined [mean difference (MD) 0.69%, 95% confidence interval (CI) -0.78 to 2.17] or post-menopausal women (MD -1.10%, 95% CI -3.22 to 1.03). However, there was a modest increase in mammographic density in premenopausal women (MD 1.83%, 95% CI 0.25-3.40) without heterogeneity but this effect was lost in one of three sensitivity analyses.ConclusionsIsoflavone intake does not alter breast density in post-menopausal women, but may cause a small increase in breast density in premenopausal women. Larger, long-term trials are required to determine if these small effects are clinically relevant.

Published
2010

45. The gut microbiome modulates associations between adherence to a Mediterranean-style diet, abdominal adiposity, and C-reactive protein in population-level analysis

Author

Jennings, Amy, primary, Kühn, Tilman, additional, Bondonno, Nicola P., additional, Waniek, Sabina, additional, Bang, Corinna, additional, Franke, Andre, additional, Kassubek, Jan, additional, Müller, Hans-Peter, additional, Both, Marcus, additional, Weber, Katharina S., additional, Lieb, Wolfgang, additional, and Cassidy, Aedín, additional

Published
2023
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