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Your search keyword '"Castel, Marie-Noëlle"' showing total 12 results
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12 results on '"Castel, Marie-Noëlle"'

2. Development of a novel NURR1/NOT agonist from hit to lead and candidate for the potential treatment of Parkinson's disease

Author

Lesuisse, Dominique, Malanda, André, Peyronel, Jean-François, Evanno, Yannick, Lardenois, Patrick, De-Peretti, Danielle, Abécassis, Pierre-Yves, Barnéoud, Pascal, Brunel, Pascale, Burgevin, Marie-Claude, Cegarra, Céline, Auger, Florian, Dommergue, Amélie, Lafon, Corinne, Even, Luc, Tsi, Joanna, Luc, Thy Phuong Hieu, Almario, Antonio, Olivier, Anne, Castel, Marie-Noëlle, Taupin, Véronique, Rooney, Thomas, and Vigé, Xavier

Published
2019
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4. In vivo imaging of neuroinflammation in the rodent brain with [11C]SSR180575, a novel indoleacetamide radioligand of the translocator protein (18 kDa)

Author

Chauveau, Fabien, primary, Boutin, Hervé, additional, Van Camp, Nadja, additional, Thominiaux, Cyrille, additional, Hantraye, Philippe, additional, Rivron, Luc, additional, Marguet, Frank, additional, Castel, Marie-Noëlle, additional, Rooney, Thomas, additional, Benavides, Jesus, additional, Dollé, Frédéric, additional, and Tavitian, Bertrand, additional

Published
2010
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9. In vivo imaging of neuroinflammation in the rodent brain with [C]SSR180575, a novel indoleacetamide radioligand of the translocator protein (18 kDa).

Author

Chauveau, Fabien, Boutin, Hervé, Camp, Nadja Van, Thominiaux, Cyrille, Hantraye, Philippe, Rivron, Luc, Marguet, Frank, Castel, Marie-Noëlle, Rooney, Thomas, Benavides, Jesus, Dollé, Frédéric, and Tavitian, Bertrand

Subjects
RADIOLIGAND assay, BIOMARKERS, PROTEIN analysis, ISOQUINOLINE, BENZODIAZEPINE receptors, LABORATORY rodents, PHYSIOLOGY
Abstract

Purpose: Neuroinflammation is involved in neurological disorders through the activation of microglial cells. Imaging of neuroinflammation with radioligands for the translocator protein (18 kDa) (TSPO) could prove to be an attractive biomarker for disease diagnosis and therapeutic evaluation. The indoleacetamide-derived 7-chloro- N, N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4 H-pyridazino[4,5- b]indole-1-acetamide, SSR180575, is a selective high-affinity TSPO ligand in human and rodents with neuroprotective effects. Methods: Here we report the radiolabelling of SSR180575 with C and in vitro and in vivo imaging in an acute model of neuroinflammation in rats. Results: The image contrast and the binding of [C]SSR180575 are higher than that obtained with the isoquinoline-based TSPO radioligand, [C]PK11195. Competition studies demonstrate that [C]SSR180575 has high specific binding for the TSPO. Conclusion: [C]SSR180575 is the first PET radioligand for the TSPO based on an indoleacetamide scaffold designed for imaging neuroinflammation in animal models and in the clinic. [ABSTRACT FROM AUTHOR]

Published
2011
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