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523 results on '"Castellano R"'

3. Renal Perfusion During Aortic Surgery: Looking for the Ideal Substrate : Curitiba Trial Investigators

Author

Tshomba, Y., Simonini, E., Colombo, E., Ardita, V., Apruzzi, L., Rinaldi, E., Pasin, L., Cambiaghi, T., Catenaccio, B., Castellano, R., Venturini, M., Landoni, G., Nardelli, P., Leopardi, M., Espinar, E., Salvati, S., Lembo, R., Baccellieri, D., Bertoglio, L., Kahlberg, A., Bossi, S., Melissano, G., Chiesa, Roberto, Tshomba, Yamume, editor, Baccellieri, Domenico, editor, and Chiesa, Roberto, editor

Published
2019
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7. A chemogenomic approach to identify personalized therapy for patients with relapse or refractory acute myeloid leukemia: results of a prospective feasibility study

Author

Collignon, A., Hospital, M. A., Montersino, C., Courtier, F., Charbonnier, A., Saillard, C., D’Incan, E., Mohty, B., Guille, A., Adelaïde, J., Carbuccia, N., Garnier, S., Mozziconacci, M. J., Zemmour, C., Pakradouni, J., Restouin, A., Castellano, R., Chaffanet, M., Birnbaum, D., Collette, Y., and Vey, N.

Published
2020
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8. Español down under: Spanish for Australia and New Zealand

Author

Lopez Castellano, R, Holas, I, Ríos Rodriguez, F, Lopez Castellano, R, Holas, I, and Ríos Rodriguez, F

Abstract

This book focuses on a hands-on, student-centric approach to learning Spanish. Designed for the Australian and New Zealand environment for use at Deakin University, currently available is foundation level content, suitable for a first introduction to Spanish speaking. The resource is still in development with additional content progressing to more advanced skill levels currently under development.

Published
2023

9. Variation in the COVID-19 infection–fatality ratio by age, time, and geography during the pre-vaccine era: a systematic analysis

Author

Sorensen, Rjd, Barber, Rm, Pigott, Dm, Carter, A, Spencer, Cn, Ostroff, Sm, Reiner, Rc, Abbafati, C, Adolph, C, Allorant, A, Amlag, Jo, Aravkin, Ay, Bachmeier, Sd, Bang-Jensen, Bl, Bisignano, C, Bloom, Ss, Castellano, R, Castro, E, Collins, Jk, Comfort, H, Dai, Xc, Dangel, Wj, Dapper, C, Deen, A, Earl, L, Erickson, M, Ewald, Sb, Ferrari, Aj, Flaxman, Ad, Frostad, Jj, Fullman, N, Gamkrelidze, A, Giles, Jr, Guo, Gr, Jw, He, Helak, M, Hulland, En, Huntley, Bm, Kereselidze, M, Lazzar-Atwood, A, Legrand, Ke, Lindstrom, A, Linebarger, E, Lozano, R, Magistro, B, Malta, Dc, Mansson, J, Herrera, Amm, Marinho, F, Mirkuzie, Ah, Mokdad, Ah, Monasta, L, Naghavi, M, Nassereldine, H, Nomura, S, Odell, Cm, Olana, Lt, Pasovic, M, Pease, Sa, Penberthy, L, Reinke, G, Ribeiro, Alp, Santomauro, Df, Sholokhov, A, Skhvitaridze, N, Spurlock, Ee, Syailendrawati, R, Topor-Madry, R, At, Vo, Vos, T, Walcott, R, Walker, A, Watson, S, Wiysonge, Cs, Worku, Na, Zheng, P, Hay, Si, Gakidou, E, and Murray, Cjl

Subjects
infection fatality ratio, covid, General Medicine, vaccination
Published
2022
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10. Les anticorps monoclonaux chimériques anti-ICOS 314.8 inhibent les cellules tumorales et les lymphocytes T régulateurs dans le syndrome de Sézary

Author

Amatore, F., primary, Barré, M., additional, Orlanducci, F., additional, Lopez, M., additional, Castellano, R., additional, Ram-Wolff, C., additional, Gorvel, L., additional, Goubard, A., additional, Gaudy-Marqueste, C., additional, Bagot, M., additional, Bensussan, A., additional, Delaporte, E., additional, and Olive, D., additional

Published
2022
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13. Chimerized anti-ICOS 314.8 monoclonal antibodies inhibit tumor cells and regulatory T cells in patients with Sézary syndrome

Author

Amatore, FA, primary, Barre, M, additional, Orlanducci, F, additional, Lopez, M, additional, Castellano, R, additional, Ram-Wolff, C, additional, Gorvel, L, additional, Goubard, A, additional, Gaudy-Marqueste, C, additional, Bagot, M, additional, Bensussan, A, additional, Delaporte, E, additional, and Olive, D, additional

Published
2022
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15. Targeting CISH enhances natural cytotoxicity receptor signaling and reduces NK cell exhaustion to improve solid tumor immunity

Author

Bernard, P-L, Delconte, R, Pastor, S, Laletin, V, Da Silva, CC, Goubard, A, Josselin, E, Castellano, R, Krug, A, Vernerey, J, Devillier, R, Olive, D, Verhoeyen, E, Vivier, E, Huntington, ND, Nunes, J, Guittard, G, Bernard, P-L, Delconte, R, Pastor, S, Laletin, V, Da Silva, CC, Goubard, A, Josselin, E, Castellano, R, Krug, A, Vernerey, J, Devillier, R, Olive, D, Verhoeyen, E, Vivier, E, Huntington, ND, Nunes, J, and Guittard, G

Abstract

BACKGROUND: The success and limitations of current immunotherapies have pushed research toward the development of alternative approaches and the possibility to manipulate other cytotoxic immune cells such as natural killer (NK) cells. Here, we targeted an intracellular inhibiting protein 'cytokine inducible SH2-containing protein' (CISH) in NK cells to evaluate the impact on their functions and antitumor properties. METHODS: To further understand CISH functions in NK cells, we developed a conditional Cish-deficient mouse model in NK cells (Cishfl/flNcr1Ki/+ ). NK cells cytokine expression, signaling and cytotoxicity has been evaluated in vitro. Using intravenous injection of B16F10 melanoma cell line and EO711 triple negative breast cancer cell line, metastasis evaluation was performed. Then, orthotopic implantation of breast tumors was performed and tumor growth was followed using bioluminescence. Infiltration and phenotype of NK cells in the tumor was evaluated. Finally, we targeted CISH in human NK-92 or primary NK cells, using a technology combining the CRISPR(i)-dCas9 tool with a new lentiviral pseudotype. We then tested human NK cells functions. RESULTS: In Cishfl/flNcr1Ki/+ mice, we detected no developmental or homeostatic difference in NK cells. Global gene expression of Cishfl/flNcr1Ki/+ NK cells compared with Cish+/+Ncr1Ki/+ NK cells revealed upregulation of pathways and genes associated with NK cell cycling and activation. We show that CISH does not only regulate interleukin-15 (IL-15) signaling pathways but also natural cytotoxicity receptors (NCR) pathways, triggering CISH protein expression. Primed Cishfl/flNcr1Ki/+ NK cells display increased activation upon NCR stimulation. Cishfl/flNcr1Ki/+ NK cells display lower activation thresholds and Cishfl/flNcr1Ki/+ mice are more resistant to tumor metastasis and to primary breast cancer growth. CISH deletion favors NK cell accumulation to the primary tumor, optimizes NK cell killing properties and decreases T

Published
2022

22. Evaluating the determinants of environmentally-significant behaviour in Europe

Author

Punzo, G., Demetrio Panarello, Pagliuca, M. M., Castellano, R., and Punzo G., Panarello D., Pagliuca M.M., Castellano R.

Subjects
Felt responsibility, Eco-Innovation Index, Pro-environmental behaviour, Perceived values, Felt responsibility, Structural equation modelling, Eco-Innovation Index, Structural equation modelling, Pro-environmental behaviour, Perceived values
Abstract

This paper explores how citizens' perceived values and felt responsibility affect pro-environmental behaviours in the EU-28 countries, grouped according to the quartile distribution of the EU Eco-Innovation Index 2017. An SEM is tested on Eurobarometer data (2017), revealing interesting differences across the four groups which can help policy-makers in implementing well-designed strategies.

Published
2020

29. An optimization model for minimizing systemic risk

Author

Castellano, R, Cerqueti, R, Clemente, G, Grassi, R, Castellano, Rosella, Cerqueti, Roy, Clemente, Gian Paolo, Grassi, Rosanna, Castellano, R, Cerqueti, R, Clemente, G, Grassi, R, Castellano, Rosella, Cerqueti, Roy, Clemente, Gian Paolo, and Grassi, Rosanna

Abstract

This paper proposes an optimal allocation model with the main aim to minimize systemic risk related to the sovereign risk of a set of countries. The reference methodological environment is that of complex networks theory. Specifically, we consider the weighted clustering coefficient as a proxy of systemic risk, while the interconnections among countries are captured by the relationships among default probabilities of the set of countries under consideration. The selected optimization criterion is based on minimization of the mean absolute deviation. We perform empirical analyses to validate the theoretical predictions, and interpret the findings in the context of the proposed model.

Published
2021

31. Targeting CISH enhances natural cytotoxicity receptor signaling and reduces NK cell exhaustion to improve solid tumor immunity

Author

Bernard, P-L., primary, Delconte, R. B., additional, Pastor, S., additional, Laletin, V., additional, Costa Da Silva, C., additional, Goubard, A., additional, Josselin, E., additional, Castellano, R., additional, Krug, A., additional, Vernerey, J., additional, Devillier, R., additional, Olive, D., additional, Verhoeyen, E., additional, Vivier, E., additional, Huntington, N. D., additional, Nunès, J. A., additional, and Guittard, G., additional

Published
2021
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32. A syntenin-deficient microenvironment educates AML for aggressiveness

Author

Leblanc, R, primary, Fares, J, additional, Goubard, A, additional, Castellano, R, additional, Camoin, L, additional, Balzano, M, additional, Ghossoub, R, additional, Bou-Tayeh, B, additional, Fauriat, C, additional, Vey, N, additional, Borg, JP, additional, Collette, Y, additional, Aurrand-Lions, M, additional, David, G, additional, and Zimmermann, P, additional

Published
2021
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33. ICOS est fortement exprimé dans les lymphomes T cutanés épidermotropes et son ciblage permet l’inhibition des cellules tumorales

Author

Amatore, F., primary, Ortonne, N., additional, Lopez, M., additional, Orlanducci, F., additional, Castellano, R., additional, Ingen-Housz-Oro, S., additional, De Croos, A., additional, Gorvel, L., additional, Goubard, A., additional, Salvado, C., additional, Bouabdallah, R., additional, Bonnet, N., additional, Grob, J.-J., additional, Gaulard, P., additional, Bagot, M., additional, Bensussan, A., additional, Berbis, P., additional, and Olive, D., additional

Published
2020
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34. Evaluating the attitudes of Europeans towards the environment

Author

Punzo, G., Demetrio Panarello, Pagliuca, M. M., Castellano, R., and Punzo G., Panarello D., Pagliuca M.M., Castellano R.

Subjects
Eco-Innovation Index, Pro-environmental behaviour, Perceived values, Structural equation modelling, Eco-Innovation Index, Structural equation modelling, Pro-environmental behaviour, Perceived values
Abstract

This paper explores how citizens’ perceived values and felt responsibility affect pro-environmental behaviours in the EU countries, grouped according to the quartile distribution of the EU Eco-Innovation Index 2017. An SEM is tested on Eurobarometer data (2017), revealing interesting differences across the four groups which can help policy-makers in implementing well-designed strategies.

Published
2019

38. An optimization model for minimizing systemic risk

Author

Castellano, R., Cerqueti, Roy, Clemente, Gian Paolo, Grassi, R., Cerqueti R., Clemente G. P. (ORCID:0000-0001-6795-4595), Castellano, R., Cerqueti, Roy, Clemente, Gian Paolo, Grassi, R., Cerqueti R., and Clemente G. P. (ORCID:0000-0001-6795-4595)

Abstract

This paper proposes an optimal allocation model with the main aim to minimize systemic risk related to the sovereign risk of a set of countries. The reference methodological environment is that of complex networks theory. Specifically, we consider the weighted clustering coefficient as a proxy of systemic risk, while the interconnections among countries are captured by the relationships among default probabilities of the set of countries under consideration. The selected optimization criterion is based on minimization of the mean absolute deviation. We perform empirical analyses to validate the theoretical predictions, and interpret the findings in the context of the proposed model.

Published
2020

40. Understanding pro-environmental travel behaviours in Western Europe

Author

Punzo, G., Castellano, R., Demetrio Panarello, and Punzo G., Castellano R., Panarello D.

Subjects
Cross-country comparison, Gender-based analysis, Sustainable transport, Sustainable transport, Cross-country comparison, Gender-based analysis
Abstract

This study aims at understanding, from a gender perspective, the reasons behind citizens’ choice of using public transport, and whether this choice is driven by pro-environmental behaviour. Using Eurobarometer data (2013), we perform ordered logistic regressions comparatively for Germany, Italy and the Netherlands. Financial, political and environmental factors are shown to have significant roles in shaping travel behaviours, with interesting gender and cross-country differences.

Published
2018

42. Renal Perfusion During Aortic Surgery: Looking for the Ideal Substrate

Author

Tshomba, Y., Simonini, E., Colombo, E., Ardita, V., Apruzzi, L., Rinaldi, E., Pasin, L., Cambiaghi, T., Catenaccio, B., Castellano, R., Venturini, M., Landoni, G., Nardelli, P., Leopardi, M., Espinar, E., Salvati, S., Lembo, R., Baccellieri, D., Bertoglio, L., Kahlberg, A., Bossi, S., Melissano, G., and Chiesa, Roberto

Published
2019

49. THE VALUE OF HYBRID DEBRANCHING

Author

CHIESA, ROBERTO, Castellano R, Mascia D, TSHOMBA, YAMUME, MELISSANO, GERMANO, KAHLBERG , ANDREA LUITZ, Roger M. Greenhalgh, Chiesa, Roberto, Kahlberg, ANDREA LUITZ, Castellano, R, Mascia, D, Tshomba, Yamume, and Melissano, Germano

Published
2016

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