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13 results on '"Castellino, Robert Craig"'

2. Comprehensive Genomic Profiling of High-Risk Pediatric Cancer Patients Has a Measurable Impact on Clinical Care

Author

Summers, Ryan J., Castellino, Sharon M., Porter, Christopher C., MacDonald, Tobey J., Basu, Gargi D., Szelinger, Szabolcs, Bhasin, Manoj K., Cash, Thomas, Carter, Alexis B., Castellino, Robert Craig, Fangusaro, Jason R., Mitchell, Sarah G., Pauly, Melinda G., Pencheva, Bojana, Wechsler, Daniel S., Graham, Douglas K., and Goldsmith, Kelly C.

Published
2022
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3. Synthetic extracellular matrices and astrocytes provide a supportive microenvironment for the cultivation and investigation of primary pediatric gliomas

Author

Massachusetts Institute of Technology. Department of Biological Engineering, Rota, Christopher M, Brown, Alexander T, Addleson, Emily, Ives, Clara, Trumper, Ella, Pelton, Kristine, Teh, Wei Pin, Schniederjan, Matthew J, Castellino, Robert Craig, Buhrlage, Sara, Lauffenburger, Douglas A, Ligon, Keith L, Griffith, Linda G, Segal, Rosalind A, Massachusetts Institute of Technology. Department of Biological Engineering, Rota, Christopher M, Brown, Alexander T, Addleson, Emily, Ives, Clara, Trumper, Ella, Pelton, Kristine, Teh, Wei Pin, Schniederjan, Matthew J, Castellino, Robert Craig, Buhrlage, Sara, Lauffenburger, Douglas A, Ligon, Keith L, Griffith, Linda G, and Segal, Rosalind A

Abstract

Background. Pediatric gliomas comprise a diverse set of brain tumor entities that have substantial long-term ramifications for patient survival and quality of life. However, the study of these tumors is currently limited due to a lack of authentic models. Additionally, many aspects of pediatric brain tumor biology, such as tumor cell invasiveness, have been difficult to study with currently available tools. To address these issues, we developed a synthetic extracellular matrix (sECM)-based culture system to grow and study primary pediatric brain tumor cells. Methods. We developed a brain-like sECM material as a supportive scaffold for the culture of primary, patientderived pediatric glioma cells and established patient-derived cell lines. Primary juvenile brainstem-derived murine astrocytes were used as a feeder layer to support the growth of primary human tumor cells. Results. We found that our culture system facilitated the proliferation of various primary pediatric brain tumors, including low-grade gliomas, and enabled ex vivo testing of investigational therapeutics. Additionally, we found that tuning this sECM material allowed us to assess high-grade pediatric glioma cell invasion and evaluate therapeutic interventions targeting invasive behavior. Conclusion. Our sECM culture platform provides a multipurpose tool for pediatric brain tumor researchers that enables both a wide breadth of biological assays and the cultivation of diverse tumor types.

Published
2023

6. OTHR-08. Pediatric Neurologic Assessment in Neuro-oncology (pNANO) Scale: A tool to assess neurologic function for Response Assessment in Neuro-oncology (RAPNO)

Author

Malbari, Fatema, primary, Erker, Craig, additional, Driever, Pablo Hernáiz, additional, Pillay-Smiley, Natasha, additional, Avery, Robert A, additional, Castellino, Robert Craig, additional, Schouten-van Meeteren, Antoinette A Y N, additional, Lenzen, Alicia C, additional, Brandsma, Rick, additional, Kramer, Kim, additional, Baxter, Patricia A, additional, Dhall, Girish, additional, Goldman, Stewart, additional, Wen, Patrick Y, additional, Prados, Michael, additional, Packer, Roger J, additional, Warren, Katherine E, additional, and Nayak, Lakshmi, additional

Published
2022
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7. Synthetic extracellular matrices and astrocytes provide a supportive microenvironment for the cultivation and investigation of primary pediatric gliomas

Author

Rota, Christopher M, primary, Brown, Alexander T, additional, Addleson, Emily, additional, Ives, Clara, additional, Trumper, Ella, additional, Pelton, Kristine, additional, Teh, Wei Pin, additional, Schniederjan, Matthew J, additional, Castellino, Robert Craig, additional, Buhrlage, Sara, additional, Lauffenburger, Douglas A, additional, Ligon, Keith L, additional, Griffith, Linda G, additional, and Segal, Rosalind A, additional

Published
2022
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9. MBCL-25. PILOT STUDY OF A SURGERY AND CHEMOTHERAPY-ONLY APPROACH IN THE UPFRONT THERAPY OF CHILDREN WITH WNT-POSITIVE STANDARD RISK MEDULLOBLASTOMA: UPDATED OUTCOMES

Author

Cohen, Kenneth, primary, Chi, Susan, additional, Hawkins, Cynthia, additional, Rodriguez, Fausto, additional, London, Wendy, additional, Castellino, Robert Craig, additional, Aguilera, Dolly, additional, Stapleton, Stacie, additional, Ashley, David, additional, Landi, Daniel, additional, and Bandopadhayay, Pratiti, additional

Published
2020
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11. LGG-58. A PHASE II TRIAL OF POLY-ICLC IN THE MANAGEMENT OF RECURRENT OR PROGRESSIVE PEDIATRIC LOW GRADE GLIOMAS (NCT01188096): PRELIMINARY ANALYSIS

Author

Aguilera, Dolly, primary, MacDonald, Tobey, additional, Crawford, John, additional, Kadom, Nadja, additional, Janss, Anna, additional, Mazewski, Claire, additional, Castellino, Robert Craig, additional, Gray, Rachael, additional, Pu, Minya, additional, Connelly, Erin, additional, Salazar, Andres, additional, and Durden, Donald L, additional

Published
2018
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