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Your search keyword '"Casteret, Sophie"' showing total 16 results
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16 results on '"Casteret, Sophie"'

6. Ligands that potentiate the bioactivity of gonadotropins

Author

Maurel, Marie-Christine, Reiter, Eric, Jegot, Gwenhael, Durand, Guillaume, Kara, Elodie, Casteret, Sophie, Physiologie de la reproduction et des comportements [Nouzilly] (PRC), Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours-Centre National de la Recherche Scientifique (CNRS), and ProdInra, Migration

Subjects
[SDV.OT]Life Sciences [q-bio]/Other [q-bio.OT], [SDV.OT] Life Sciences [q-bio]/Other [q-bio.OT], A1
Published
2014

7. Targeting of non-viral intégrative vectors in the nuclear DNA sequences of eukaryotes

Author

Bigot, Yves, Carpentier, G., Casteret, Sophie, Piegu, Benoit, ProdInra, Migration, Physiologie de la reproduction et des comportements [Nouzilly] (PRC), Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS), and Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDV.OT]Life Sciences [q-bio]/Other [q-bio.OT], [SDV.OT] Life Sciences [q-bio]/Other [q-bio.OT], A1
Published
2014

9. Profile of the mosaic element BTMR1 in the genome of the bumble bee Bombus terrestris (Hymenoptera: Apidae)

Author

Casteret, Sophie, Moiré, Nathalie, Aupinel, Pierrick, Tasei, Jean Noel, Bigot, Yves, Centre National de la Recherche Scientifique (CNRS), Immunologie parasitaire (TOURS UMR IMMUNOLOGIE PARASIT), Institut National de la Recherche Agronomique (INRA)-Faculte des Sciences Pharmaceutiques, Entomologie (ENTOMOLOGIE), and Institut National de la Recherche Agronomique (INRA)

Subjects
BOURDON, INSECTE, MARINER, TRANSPOSON, [SDV]Life Sciences [q-bio], REPEATS, CRYPTON, RETROTRANSPOSON, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2011
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10. Properties of DNA-bindinf ro specifically locate transgene in the rRNA genes

Author

Carnus, Elodie, Demattei, Marie-Véronique, Casteret, Sophie, Palazzoli, Fabien, Renault, Sylvaine, Bigot, Yves, Génétique, immunothérapie, chimie et cancer (GICC), UMR 6239 CNRS [2008-2011] (GICC UMR 6239 CNRS), Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), and Université de Tours-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDV.BC]Life Sciences [q-bio]/Cellular Biology, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2009

11. Properties of DNA Binding Domains to Specifically Locate Transgene in the rRNA Genes

Author

Carnus, Elodie, Demattei, Marie-Veronique, Casteret, Sophie, Palazzoli, Fabien, Renault, Sylvaine, Bigot, Yves, Génétique, immunothérapie, chimie et cancer (GICC), UMR 6239 CNRS [2008-2011] (GICC UMR 6239 CNRS), Université de Tours-Centre National de la Recherche Scientifique (CNRS), Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), and Cambefort, Jeanne

Subjects
[SDV.GEN]Life Sciences [q-bio]/Genetics, [SDV.GEN] Life Sciences [q-bio]/Genetics, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2009

12. mRNA as a Source of Transposase to Secure Transgene Integration

Author

Bire, Solenne, Casteret, Sophie, Bigot, Yves, Bonnin, Florence, Génétique, immunothérapie, chimie et cancer (GICC), UMR 6239 CNRS [2008-2011] (GICC UMR 6239 CNRS), Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), Université de Tours-Centre National de la Recherche Scientifique (CNRS), and Cambefort, Jeanne

Subjects
[INFO.INFO-BT] Computer Science [cs]/Biotechnology, [SDV.BIO]Life Sciences [q-bio]/Biotechnology, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, [INFO.INFO-BT]Computer Science [cs]/Biotechnology, ComputingMilieux_MISCELLANEOUS, [SDV.BIO] Life Sciences [q-bio]/Biotechnology
Abstract

International audience

Published
2009

16. Optimization of the piggyBac Transposon Using mRNA and Insulators: Toward a More Reliable Gene Delivery System.

Author

Bire, Solenne, Ley, Déborah, Casteret, Sophie, Mermod, Nicolas, Bigot, Yves, and Rouleux-Bonnin, Florence

Subjects
MESSENGER RNA, TRANSGENE expression, GENE therapy, TRANSPOSONS, GENE silencing, TRANSPOSASES
Abstract

Integrating and expressing stably a transgene into the cellular genome remain major challenges for gene-based therapies and for bioproduction purposes. While transposon vectors mediate efficient transgene integration, expression may be limited by epigenetic silencing, and persistent transposase expression may mediate multiple transposition cycles. Here, we evaluated the delivery of the piggyBac transposase messenger RNA combined with genetically insulated transposons to isolate the transgene from neighboring regulatory elements and stabilize expression. A comparison of piggyBac transposase expression from messenger RNA and DNA vectors was carried out in terms of expression levels, transposition efficiency, transgene expression and genotoxic effects, in order to calibrate and secure the transposition-based delivery system. Messenger RNA reduced the persistence of the transposase to a narrow window, thus decreasing side effects such as superfluous genomic DNA cleavage. Both the CTF/NF1 and the D4Z4 insulators were found to mediate more efficient expression from a few transposition events. We conclude that the use of engineered piggyBac transposase mRNA and insulated transposons offer promising ways of improving the quality of the integration process and sustaining the expression of transposon vectors. [ABSTRACT FROM AUTHOR]

Published
2013
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