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1. Universal properties of Wigner delay times and resonance widths of tight-binding random graphs

Author

Hidalgo-Castro, K. B., Razo-López, L. A., Martínez-Argüello, A. M., and Méndez-Bermúdez, J. A.

Subjects
Condensed Matter - Disordered Systems and Neural Networks
Abstract

The delay experienced by a probe due to interactions with a scattering media is highly related to the internal dynamics inside that media. This property is well captured by the Wigner delay time and the resonance widths. By the use of the equivalence between the adjacency matrix of a random graph and the tight-binding Hamiltonian of the corresponding electronic media, the scattering matrix approach to electronic transport is used to compute Wigner delay times and resonance widths of Erd\"os-R\'enyi graphs and random geometric graphs, including bipartite random geometric graphs. In particular, the situation when a single-channel lead attached to the graphs is considered. Our results show a smooth crossover towards universality as the graphs become complete. We also introduce a parameter $\xi$, depending on the graph average degree $\langle k \rangle$ and graph size $N$, that scales the distributions of both Wigner delay times and resonance widths; highlighting the universal character of both distributions. Specifically, $\xi = \langle k \rangle N^{-\alpha}$ where $\alpha$ is graph-model dependent., Comment: 9 pages, 8 figures

Published
2024

2. Universal insulating-to-metallic crossover in tight-binding random geometric graphs

Author

Martínez-Argüello, A. M., Hidalgo-Castro, K. B., and Méndez-Bermúdez, J. A.

Subjects
Condensed Matter - Disordered Systems and Neural Networks, G.1 (Primary), H.1 (Secondary), G.1, H.1
Abstract

Within the scattering matrix approach to electronic transport, the scattering and transport properties of tight-binding random graphs are analyzed. In particular, we compute the scattering matrix elements, the transmission, the channel-to-channel transmission distributions (including the total transmission distribution), the shot noise power, and the elastic enhancement factor. Two graph models are considered: random geometric graphs and bipartite random geometric graphs. The results show an insulating to a metallic crossover in the scattering and transport properties by increasing the average degree of the graphs from small to large values. Also, the scattering and transport properties are shown to be invariant under a scaling parameter depending on the average degree and the graph size. Furthermore, for large connectivity and in the perfect coupling regime, the scattering and transport properties of both graph models are well described by the random matrix theory predictions of electronic transport, except for bipartite graphs in particular scattering setups., Comment: 13 pages, 16 figures

Published
2023

3. Multi-analytical characterization of an oncoid from a high altitude hypersaline lake using techniques employed in the Mars2020 and Rosalind Franklin missions on Mars

Author

Huidobro, J., Madariaga, J.M., Carrizo, D., Laserna, J.L., Rull, F., Martínez-Frías, J., Aramendia, J., Sánchez-García, L., García-Gómez, L., Vignale, F.A., Farías, M.E., Veneranda, M., Población, I., Cabalín, L.M., López-Reyes, G., Coloma, L., García-Florentino, C., Arana, G., Castro, K., Delgado, T., Álvarez-Llamas, C., Fortes, F.J., and Manrique, J.A.

Published
2023
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5. Homogeneity assessment of the SuperCam calibration targets onboard rover perseverance

Author

Madariaga, J.M., Aramendia, J., Arana, G., Castro, K., Gómez-Nubla, L., Fdez-Ortiz de Vallejuelo, S., Garcia-Florentino, C., Maguregui, M., Manrique, J.A., Lopez-Reyes, G., Moros, J., Cousin, A., Maurice, S., Ollila, A.M., Wiens, R.C., Rull, F., Laserna, J., Garcia-Baonza, V., Madsen, M.B., Forni, O., Lasue, J., Clegg, S.M., Robinson, S., Bernardi, P., Brown, A.J., Caïs, P., Martinez-Frias, J., Beck, P., Bernard, S., Bernt, M.H., Beyssac, O., Cloutis, E., Drouet, C., Dromart, G., Dubois, B., Fabre, C., Gasnault, O., Gontijo, I., Johnson, J.R., Medina, J., Meslin, P.-Y., Montagnac, G., Sautter, V., Sharma, S.K., Veneranda, M., and Willis, P.A.

Published
2022
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12. Prognostic relevance of gait-related cognitive functions for dementia conversion in amnestic mild cognitive impairment

Author

Tuena, C, Maestri, S, Serino, S, Pedroli, E, Stramba-Badiale, M, Riva, G, Silbert, L, Lind, B, Crissey, R, Kaye, J, Carter, R, Dolen, S, Quinn, J, Schneider, L, Pawluczyk, S, Becerra, M, Teodoro, L, Dagerman, K, Spann, B, Brewer, J, Fleisher, A, Vanderswag, H, Ziolkowski, J, Heidebrink, J, Zbizek-Nulph, L, Lord, J, Albers, C, Petersen, R, Mason, S, Knopman, D, Johnson, K, Villanueva-Meyer, J, Pavlik, V, Pacini, N, Lamb, A, Kass, J, Doody, R, Shibley, V, Chowdhury, M, Rountree, S, Dang, M, Stern, Y, Honig, L, Mintz, A, Ances, B, Morris, J, Winkfield, D, Carroll, M, Stobbs-Cucchi, G, Oliver, A, Creech, M, Mintun, M, Schneider, S, Geldmacher, D, Love, M, Griffith, R, Clark, D, Brockington, J, Marson, D, Grossman, H, Goldstein, M, Greenberg, J, Mitsis, E, Shah, R, Lamar, M, Samuels, P, Duara, R, Greig-Custo, M, Rodriguez, R, Albert, M, Onyike, C, Farrington, L, Rudow, S, Brichko, R, Kielb, S, Smith, A, Raj, B, Fargher, K, Sadowski, M, Wisniewski, T, Shulman, M, Faustin, A, Rao, J, Castro, K, Ulysse, A, Chen, S, Doraiswamy, P, Petrella, J, James, O, Wong, T, Borges-Neto, S, Karlawish, J, Wolk, D, Vaishnavi, S, Clark, C, Arnold, S, Smith, C, Jicha, G, Khouli, R, Raslau, F, Lopez, O, Oakley, M, Simpson, D, Porsteinsson, A, Martin, K, Kowalski, N, Keltz, M, Goldstein, B, Makino, K, Ismail, M, Brand, C, Thai, G, Pierce, A, Yanez, B, Sosa, E, Witbracht, M, Kelley, B, Nguyen, T, Womack, K, Mathews, D, Quiceno, M, Levey, A, Lah, J, Hajjar, I, Burns, J, Swerdlow, R, Brooks, W, Silverman, D, Kremen, S, Apostolova, L, Tingus, K, Lu, P, Bartzokis, G, Woo, E, Teng, E, Graff-Radford, N, Parfitt, F, Poki-Walker, K, Farlow, M, Hake, A, Matthews, B, Brosch, J, Herring, S, van Dyck, C, Mecca, A, Good, S, Macavoy, M, Carson, R, Varma, P, Chertkow, H, Vaitekunas, S, Hosein, C, Black, S, Stefanovic, B, Heyn, C, Hsiung, G, Kim, E, Mudge, B, Sossi, V, Feldman, H, Assaly, M, Finger, E, Pasternak, S, Rachinsky, I, Kertesz, A, Drost, D, Rogers, J, Grant, I, Muse, B, Rogalski, E, Robson, J, Mesulam, M, Kerwin, D, Wu, C, Johnson, N, Lipowski, K, Weintraub, S, Bonakdarpour, B, Pomara, N, Hernando, R, Sarrael, A, Rosen, H, Miller, B, Weiner, M, Perry, D, Turner, R, Reynolds, B, Mccann, K, Poe, J, Marshall, G, Sperling, R, Yesavage, J, Taylor, J, Chao, S, Coleman, J, White, J, Lane, B, Rosen, A, Tinklenberg, J, Belden, C, Atri, A, Clark, K, Zamrini, E, Sabbagh, M, Killiany, R, Stern, R, Mez, J, Kowall, N, Budson, A, Obisesan, T, Ntekim, O, Wolday, S, Khan, J, Nwulia, E, Nadarajah, S, Lerner, A, Ogrocki, P, Tatsuoka, C, Fatica, P, Fletcher, E, Maillard, P, Olichney, J, Decarli, C, Carmichael, O, Bates, V, Capote, H, Rainka, M, Borrie, M, Lee, T, Bartha, R, Johnson, S, Asthana, S, Carlsson, C, Perrin, A, Burke, A, Scharre, D, Kataki, M, Tarawneh, R, Hart, D, Zimmerman, E, Celmins, D, Miller, D, Ponto, L, Smith, K, Koleva, H, Shim, H, Nam, K, Schultz, S, Williamson, J, Craft, S, Cleveland, J, Yang, M, Sink, K, Ott, B, Drake, J, Tremont, G, Daiello, L, Ritter, A, Bernick, C, Munic, D, O'Connelll, A, Mintzer, J, Wiliams, A, Masdeu, J, Shi, J, Garcia, A, Newhouse, P, Potkin, S, Salloway, S, Malloy, P, Correia, S, Kittur, S, Pearlson, G, Blank, K, Anderson, K, Flashman, L, Seltzer, M, Hynes, M, Santulli, R, Relkin, N, Chiang, G, Lee, A, Lin, M, Ravdin, L, Tuena C., Maestri S., Serino S., Pedroli E., Stramba-Badiale M., Riva G., Silbert L. C., Lind B., Crissey R., Kaye J. A., Carter R., Dolen S., Quinn J., Schneider L. S., Pawluczyk S., Becerra M., Teodoro L., Dagerman K., Spann B. M., Brewer J., Fleisher A., Vanderswag H., Ziolkowski J., Heidebrink J. L., Zbizek-Nulph L., Lord J. L., Albers C. S., Petersen R., Mason S. S., Knopman D., Johnson K., Villanueva-Meyer J., Pavlik V., Pacini N., Lamb A., Kass J. S., Doody R. S., Shibley V., Chowdhury M., Rountree S., Dang M., Stern Y., Honig L. S., Mintz A., Ances B., Morris J. C., Winkfield D., Carroll M., Stobbs-Cucchi G., Oliver A., Creech M. L., Mintun M. A., Schneider S., Geldmacher D., Love M. N., Griffith R., Clark D., Brockington J., Marson D., Grossman H., Goldstein M. A., Greenberg J., Mitsis E., Shah R. C., Lamar M., Samuels P., Duara R., Greig-Custo M. T., Rodriguez R., Albert M., Onyike C., Farrington L., Rudow S., Brichko R., Kielb S., Smith A., Raj B. A., Fargher K., Sadowski M., Wisniewski T., Shulman M., Faustin A., Rao J., Castro K. M., Ulysse A., Chen S., Doraiswamy P. M., Petrella J. R., James O., Wong T. Z., Borges-Neto S., Karlawish J. H., Wolk D. A., Vaishnavi S., Clark C. M., Arnold S. E., Smith C. D., Jicha G. A., Khouli R. E., Raslau F. D., Lopez O. L., Oakley M. A., Simpson D. M., Porsteinsson A. P., Martin K., Kowalski N., Keltz M., Goldstein B. S., Makino K. M., Ismail M. S., Brand C., Thai G., Pierce A., Yanez B., Sosa E., Witbracht M., Kelley B., Nguyen T., Womack K., Mathews D., Quiceno M., Levey A. I., Lah J. J., Hajjar I., Burns J. M., Swerdlow R. H., Brooks W. M., Silverman D. H. S., Kremen S., Apostolova L., Tingus K., Lu P. H., Bartzokis G., Woo E., Teng E., Graff-Radford N. R., Parfitt F., Poki-Walker K., Farlow M. R., Hake A. M., Matthews B. R., Brosch J. R., Herring S., van Dyck C. H., Mecca A. P., Good S. P., MacAvoy M. G., Carson R. E., Varma P., Chertkow H., Vaitekunas S., Hosein C., Black S., Stefanovic B., Heyn C., Hsiung G. -Y. R., Kim E., Mudge B., Sossi V., Feldman H., Assaly M., Finger E., Pasternak S., Rachinsky I., Kertesz A., Drost D., Rogers J., Grant I., Muse B., Rogalski E., Robson J., Mesulam M. -M., Kerwin D., Wu C. -K., Johnson N., Lipowski K., Weintraub S., Bonakdarpour B., Pomara N., Hernando R., Sarrael A., Rosen H. J., Miller B. L., Weiner M. W., Perry D., Turner R. S., Reynolds B., MCCann K., Poe J., Marshall G. A., Sperling R. A., Johnson K. A., Yesavage J., Taylor J. L., Chao S., Coleman J., White J. D., Lane B., Rosen A., Tinklenberg J., Belden C. M., Atri A., Clark K. A., Zamrini E., Sabbagh M., Killiany R., Stern R., Mez J., Kowall N., Budson A. E., Obisesan T. O., Ntekim O. E., Wolday S., Khan J. I., Nwulia E., Nadarajah S., Lerner A., Ogrocki P., Tatsuoka C., Fatica P., Fletcher E., Maillard P., Olichney J., DeCarli C., Carmichael O., Bates V., Capote H., Rainka M., Borrie M., Lee T. -Y., Bartha R., Johnson S., Asthana S., Carlsson C. M., Perrin A., Burke A., Scharre D. W., Kataki M., Tarawneh R., Hart D., Zimmerman E. A., Celmins D., Miller D. D., Ponto L. L. B., Smith K. E., Koleva H., Shim H., Nam K. W., Schultz S. K., Williamson J. D., Craft S., Cleveland J., Yang M., Sink K. M., Ott B. R., Drake J., Tremont G., Daiello L. A., Drake J. D., Ritter A., Bernick C., Munic D., O'Connelll A., Mintzer J., Wiliams A., Masdeu J., Shi J., Garcia A., Newhouse P., Potkin S., Salloway S., Malloy P., Correia S., Kittur S., Pearlson G. D., Blank K., Anderson K., Flashman L. A., Seltzer M., Hynes M. L., Santulli R. B., Relkin N., Chiang G., Lee A., Lin M., Ravdin L., Tuena, C, Maestri, S, Serino, S, Pedroli, E, Stramba-Badiale, M, Riva, G, Silbert, L, Lind, B, Crissey, R, Kaye, J, Carter, R, Dolen, S, Quinn, J, Schneider, L, Pawluczyk, S, Becerra, M, Teodoro, L, Dagerman, K, Spann, B, Brewer, J, Fleisher, A, Vanderswag, H, Ziolkowski, J, Heidebrink, J, Zbizek-Nulph, L, Lord, J, Albers, C, Petersen, R, Mason, S, Knopman, D, Johnson, K, Villanueva-Meyer, J, Pavlik, V, Pacini, N, Lamb, A, Kass, J, Doody, R, Shibley, V, Chowdhury, M, Rountree, S, Dang, M, Stern, Y, Honig, L, Mintz, A, Ances, B, Morris, J, Winkfield, D, Carroll, M, Stobbs-Cucchi, G, Oliver, A, Creech, M, Mintun, M, Schneider, S, Geldmacher, D, Love, M, Griffith, R, Clark, D, Brockington, J, Marson, D, Grossman, H, Goldstein, M, Greenberg, J, Mitsis, E, Shah, R, Lamar, M, Samuels, P, Duara, R, Greig-Custo, M, Rodriguez, R, Albert, M, Onyike, C, Farrington, L, Rudow, S, Brichko, R, Kielb, S, Smith, A, Raj, B, Fargher, K, Sadowski, M, Wisniewski, T, Shulman, M, Faustin, A, Rao, J, Castro, K, Ulysse, A, Chen, S, Doraiswamy, P, Petrella, J, James, O, Wong, T, Borges-Neto, S, Karlawish, J, Wolk, D, Vaishnavi, S, Clark, C, Arnold, S, Smith, C, Jicha, G, Khouli, R, Raslau, F, Lopez, O, Oakley, M, Simpson, D, Porsteinsson, A, Martin, K, Kowalski, N, Keltz, M, Goldstein, B, Makino, K, Ismail, M, Brand, C, Thai, G, Pierce, A, Yanez, B, Sosa, E, Witbracht, M, Kelley, B, Nguyen, T, Womack, K, Mathews, D, Quiceno, M, Levey, A, Lah, J, Hajjar, I, Burns, J, Swerdlow, R, Brooks, W, Silverman, D, Kremen, S, Apostolova, L, Tingus, K, Lu, P, Bartzokis, G, Woo, E, Teng, E, Graff-Radford, N, Parfitt, F, Poki-Walker, K, Farlow, M, Hake, A, Matthews, B, Brosch, J, Herring, S, van Dyck, C, Mecca, A, Good, S, Macavoy, M, Carson, R, Varma, P, Chertkow, H, Vaitekunas, S, Hosein, C, Black, S, Stefanovic, B, Heyn, C, Hsiung, G, Kim, E, Mudge, B, Sossi, V, Feldman, H, Assaly, M, Finger, E, Pasternak, S, Rachinsky, I, Kertesz, A, Drost, D, Rogers, J, Grant, I, Muse, B, Rogalski, E, Robson, J, Mesulam, M, Kerwin, D, Wu, C, Johnson, N, Lipowski, K, Weintraub, S, Bonakdarpour, B, Pomara, N, Hernando, R, Sarrael, A, Rosen, H, Miller, B, Weiner, M, Perry, D, Turner, R, Reynolds, B, Mccann, K, Poe, J, Marshall, G, Sperling, R, Yesavage, J, Taylor, J, Chao, S, Coleman, J, White, J, Lane, B, Rosen, A, Tinklenberg, J, Belden, C, Atri, A, Clark, K, Zamrini, E, Sabbagh, M, Killiany, R, Stern, R, Mez, J, Kowall, N, Budson, A, Obisesan, T, Ntekim, O, Wolday, S, Khan, J, Nwulia, E, Nadarajah, S, Lerner, A, Ogrocki, P, Tatsuoka, C, Fatica, P, Fletcher, E, Maillard, P, Olichney, J, Decarli, C, Carmichael, O, Bates, V, Capote, H, Rainka, M, Borrie, M, Lee, T, Bartha, R, Johnson, S, Asthana, S, Carlsson, C, Perrin, A, Burke, A, Scharre, D, Kataki, M, Tarawneh, R, Hart, D, Zimmerman, E, Celmins, D, Miller, D, Ponto, L, Smith, K, Koleva, H, Shim, H, Nam, K, Schultz, S, Williamson, J, Craft, S, Cleveland, J, Yang, M, Sink, K, Ott, B, Drake, J, Tremont, G, Daiello, L, Ritter, A, Bernick, C, Munic, D, O'Connelll, A, Mintzer, J, Wiliams, A, Masdeu, J, Shi, J, Garcia, A, Newhouse, P, Potkin, S, Salloway, S, Malloy, P, Correia, S, Kittur, S, Pearlson, G, Blank, K, Anderson, K, Flashman, L, Seltzer, M, Hynes, M, Santulli, R, Relkin, N, Chiang, G, Lee, A, Lin, M, Ravdin, L, Tuena C., Maestri S., Serino S., Pedroli E., Stramba-Badiale M., Riva G., Silbert L. C., Lind B., Crissey R., Kaye J. A., Carter R., Dolen S., Quinn J., Schneider L. S., Pawluczyk S., Becerra M., Teodoro L., Dagerman K., Spann B. M., Brewer J., Fleisher A., Vanderswag H., Ziolkowski J., Heidebrink J. L., Zbizek-Nulph L., Lord J. L., Albers C. S., Petersen R., Mason S. S., Knopman D., Johnson K., Villanueva-Meyer J., Pavlik V., Pacini N., Lamb A., Kass J. S., Doody R. S., Shibley V., Chowdhury M., Rountree S., Dang M., Stern Y., Honig L. S., Mintz A., Ances B., Morris J. C., Winkfield D., Carroll M., Stobbs-Cucchi G., Oliver A., Creech M. L., Mintun M. A., Schneider S., Geldmacher D., Love M. N., Griffith R., Clark D., Brockington J., Marson D., Grossman H., Goldstein M. A., Greenberg J., Mitsis E., Shah R. C., Lamar M., Samuels P., Duara R., Greig-Custo M. T., Rodriguez R., Albert M., Onyike C., Farrington L., Rudow S., Brichko R., Kielb S., Smith A., Raj B. A., Fargher K., Sadowski M., Wisniewski T., Shulman M., Faustin A., Rao J., Castro K. M., Ulysse A., Chen S., Doraiswamy P. M., Petrella J. R., James O., Wong T. Z., Borges-Neto S., Karlawish J. H., Wolk D. A., Vaishnavi S., Clark C. M., Arnold S. E., Smith C. D., Jicha G. A., Khouli R. E., Raslau F. D., Lopez O. L., Oakley M. A., Simpson D. M., Porsteinsson A. P., Martin K., Kowalski N., Keltz M., Goldstein B. S., Makino K. M., Ismail M. S., Brand C., Thai G., Pierce A., Yanez B., Sosa E., Witbracht M., Kelley B., Nguyen T., Womack K., Mathews D., Quiceno M., Levey A. I., Lah J. J., Hajjar I., Burns J. M., Swerdlow R. H., Brooks W. M., Silverman D. H. S., Kremen S., Apostolova L., Tingus K., Lu P. H., Bartzokis G., Woo E., Teng E., Graff-Radford N. R., Parfitt F., Poki-Walker K., Farlow M. R., Hake A. M., Matthews B. R., Brosch J. R., Herring S., van Dyck C. H., Mecca A. P., Good S. P., MacAvoy M. G., Carson R. E., Varma P., Chertkow H., Vaitekunas S., Hosein C., Black S., Stefanovic B., Heyn C., Hsiung G. -Y. R., Kim E., Mudge B., Sossi V., Feldman H., Assaly M., Finger E., Pasternak S., Rachinsky I., Kertesz A., Drost D., Rogers J., Grant I., Muse B., Rogalski E., Robson J., Mesulam M. -M., Kerwin D., Wu C. -K., Johnson N., Lipowski K., Weintraub S., Bonakdarpour B., Pomara N., Hernando R., Sarrael A., Rosen H. J., Miller B. L., Weiner M. W., Perry D., Turner R. S., Reynolds B., MCCann K., Poe J., Marshall G. A., Sperling R. A., Johnson K. A., Yesavage J., Taylor J. L., Chao S., Coleman J., White J. D., Lane B., Rosen A., Tinklenberg J., Belden C. M., Atri A., Clark K. A., Zamrini E., Sabbagh M., Killiany R., Stern R., Mez J., Kowall N., Budson A. E., Obisesan T. O., Ntekim O. E., Wolday S., Khan J. I., Nwulia E., Nadarajah S., Lerner A., Ogrocki P., Tatsuoka C., Fatica P., Fletcher E., Maillard P., Olichney J., DeCarli C., Carmichael O., Bates V., Capote H., Rainka M., Borrie M., Lee T. -Y., Bartha R., Johnson S., Asthana S., Carlsson C. M., Perrin A., Burke A., Scharre D. W., Kataki M., Tarawneh R., Hart D., Zimmerman E. A., Celmins D., Miller D. D., Ponto L. L. B., Smith K. E., Koleva H., Shim H., Nam K. W., Schultz S. K., Williamson J. D., Craft S., Cleveland J., Yang M., Sink K. M., Ott B. R., Drake J., Tremont G., Daiello L. A., Drake J. D., Ritter A., Bernick C., Munic D., O'Connelll A., Mintzer J., Wiliams A., Masdeu J., Shi J., Garcia A., Newhouse P., Potkin S., Salloway S., Malloy P., Correia S., Kittur S., Pearlson G. D., Blank K., Anderson K., Flashman L. A., Seltzer M., Hynes M. L., Santulli R. B., Relkin N., Chiang G., Lee A., Lin M., and Ravdin L.

Abstract

Background: Increasing research suggests that gait abnormalities can be a risk factor for Alzheimer’s Disease (AD). Notably, there is growing evidence highlighting this risk factor in individuals with amnestic Mild Cognitive Impairment (aMCI), however further studies are needed. The aim of this study is to analyze cognitive tests results and brain-related measures over time in aMCI and examine how the presence of gait abnormalities (neurological or orthopedic) or normal gait affects these trends. Additionally, we sought to assess the significance of gait and gait-related measures as prognostic indicators for the progression from aMCI to AD dementia, comparing those who converted to AD with those who remained with a stable aMCI diagnosis during the follow-up. Methods: Four hundred two individuals with aMCI from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database were included. Robust linear mixed-effects models were used to study the impact of gait abnormalities on a comprehensive neuropsychological battery over 36 months while controlling for relevant medical variables at baseline. The impact of gait on brain measures was also investigated. Lastly, the Cox proportional-hazards model was used to explore the prognostic relevance of abnormal gait and neuropsychological associated tests. Results: While controlling for relevant covariates, we found that gait abnormalities led to a greater decline over time in attention (DSST) and global cognition (MMSE). Intriguingly, psychomotor speed (TMT-A) and divided attention (TMT-B) declined uniquely in the abnormal gait group. Conversely, specific AD global cognition tests (ADAS-13) and auditory-verbal memory (RAVLT immediate recall) declined over time independently of gait profile. All the other cognitive tests were not significantly affected by time or by gait profile. In addition, we found that ventricles size increased faster in the abnormal gait group compared to the normal gait group. In terms of prognosis, abno

Published
2023

17. The SuperCam Instrument Suite on the Mars 2020 Rover: Science Objectives and Mast-Unit Description

Author

Maurice, S., Wiens, R. C., Bernardi, P., Caïs, P., Robinson, S., Nelson, T., Gasnault, O., Reess, J.-M., Deleuze, M., Rull, F., Manrique, J.-A., Abbaki, S., Anderson, R. B., André, Y., Angel, S. M., Arana, G., Battault, T., Beck, P., Benzerara, K., Bernard, S., Berthias, J.-P., Beyssac, O., Bonafous, M., Bousquet, B., Boutillier, M., Cadu, A., Castro, K., Chapron, F., Chide, B., Clark, K., Clavé, E., Clegg, S., Cloutis, E., Collin, C., Cordoba, E. C., Cousin, A., Dameury, J.-C., D’Anna, W., Daydou, Y., Debus, A., Deflores, L., Dehouck, E., Delapp, D., De Los Santos, G., Donny, C., Doressoundiram, A., Dromart, G., Dubois, B., Dufour, A., Dupieux, M., Egan, M., Ervin, J., Fabre, C., Fau, A., Fischer, W., Forni, O., Fouchet, T., Frydenvang, J., Gauffre, S., Gauthier, M., Gharakanian, V., Gilard, O., Gontijo, I., Gonzalez, R., Granena, D., Grotzinger, J., Hassen-Khodja, R., Heim, M., Hello, Y., Hervet, G., Humeau, O., Jacob, X., Jacquinod, S., Johnson, J. R., Kouach, D., Lacombe, G., Lanza, N., Lapauw, L., Laserna, J., Lasue, J., Le Deit, L., Le Mouélic, S., Le Comte, E., Lee, Q.-M., Legett, IV, C., Leveille, R., Lewin, E., Leyrat, C., Lopez-Reyes, G., Lorenz, R., Lucero, B., Madariaga, J. M., Madsen, S., Madsen, M., Mangold, N., Manni, F., Mariscal, J.-F., Martinez-Frias, J., Mathieu, K., Mathon, R., McCabe, K. P., McConnochie, T., McLennan, S. M., Mekki, J., Melikechi, N., Meslin, P.-Y., Micheau, Y., Michel, Y., Michel, J. M., Mimoun, D., Misra, A., Montagnac, G., Montaron, C., Montmessin, F., Moros, J., Mousset, V., Morizet, Y., Murdoch, N., Newell, R. T., Newsom, H., Nguyen Tuong, N., Ollila, A. M., Orttner, G., Oudda, L., Pares, L., Parisot, J., Parot, Y., Pérez, R., Pheav, D., Picot, L., Pilleri, P., Pilorget, C., Pinet, P., Pont, G., Poulet, F., Quantin-Nataf, C., Quertier, B., Rambaud, D., Rapin, W., Romano, P., Roucayrol, L., Royer, C., Ruellan, M., Sandoval, B. F., Sautter, V., Schoppers, M. J., Schröder, S., Seran, H.-C., Sharma, S. K., Sobron, P., Sodki, M., Sournac, A., Sridhar, V., Standarovsky, D., Storms, S., Striebig, N., Tatat, M., Toplis, M., Torre-Fdez, I., Toulemont, N., Velasco, C., Veneranda, M., Venhaus, D., Virmontois, C., Viso, M., Willis, P., and Wong, K. W.

Published
2021
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18. Antiplatelet therapy with aspirin, clopidogrel, and dipyridamole versus clopidogrel alone or aspirin and dipyridamole in patients with acute cerebral ischaemia (TARDIS): a randomised, open-label, phase 3 superiority trial

Author

Christensen, L M, Bentsen, L, Krarup Hansen, C, Thomsen, T T, Kruuse, C, Jensen, H H, Hansen, S S, Petrovic, V, Beridze, N, Kakabadze, N, Kherkheulidze, T, Kakabadze, D, Toidze, I, Lobjanidze, N, Akiashvili, N, Tevdoradze, A, Khizanishvili, N, Tsanava, T, Taylor, R, Iniesta, I, Kok, J, Duignan, J, Funnell, M, Cariga, P, Rodriguez, M, Watson, I J, Tennant, S, Macleod, M, Furnace, J, Gow, H, Irvine, J, Joyson, A, Nelson, S, Taylor, V, Smith, M, Bellfield, R, Hairsine, B, Davies, R, Dodd, A, Corrigan, J, Doherty, M, Ahmed, A, Denniss, C, Johnson-Holland, S, Kay, K A, Palau, R Icart, Auld, G, Daboo, P, Erande, R, Grimwood, G, Hove, D, Howaniec, L, Redjep, O, Rangasamay, R, Butt, G, Sandler, D, Reddan, J, Stafford, S, McIlmoyle, J, Maguire, S, Murphy, P, Chambers, J, Guthrie, L, Osborn, M, Steele, A, Burn, M, Benford, A, Misra, A, Hilton, D, O'Brien, E, Amis, E, Finlay, S, Mitchell, J, Geraghty, O, Harvey, K, Hazel, B, Mashate, S, Wilding, P, Sajid, M, Ball, M, Gascoyne, R, Sivakumar, R, Wright, A, Chatterjee, K, Booth, S, Eccleson, H, Kelly, C, Leason, S, Perkins, C, Bruce, D, Brown, E, Clayton, S, Garside, M, Rogers, G, Lawrence, E, Mahmood, S, Watchurst, C, Chadha, D, Glover, L, Holford, L, Smith, K, Walstow, D, Williams, R, O'Shea, L, Goodsell, J, Athulathmudali, C, Barbon, E, Namushi, R, Jacob, P, Johnson, L, Morse, D, McGhee, C, Speirs, O, Atkinson, S, Peacocke, A, Langhorne, P, Graham, R, Wright, F, McAlpine, C, Ravindrane, A, Bajoriene, M, Matter, L, Windebank, S, Giallombardo, E, Dellafera, D, Eglinton, C, Wilson, J, Broughton, D, Chapman, K, Dixon, L, Zaidi, M, Ayes, K, Kessell, J, Manawadu, D, Adegbaju, O, Aeron-Thomas, J, Anderson, K, Brigden, A, Cattermole, E, Good, J, Hassan, S, Khoromana, E, Lee-Carbon, L, Marks, K, Mckenzie, E, Sikondari, N, Cooper, M, Whysall, K, Wynter, I, Bamford, J, Hassan, A, Wanklyn, P, Kambafwile, M, Makawa, L, Waugh, D, Veraque, E, Soliman, MGG, Arif, S, Brown, R, Butler, S, Hewitt, C, Hindle, J, Pusalkar, A, Beadle, H, Chan, K, Siddiqui, M, Dangri, P, Buddha, S, Asokanathan, A, Mistri, A, Eveson, D, Musarrat, K, Manning, L, Anand, S, Christian, P, Khan, S, Patel, C, Sein, M, Banns, J, Gibson, E, Gordon, T, Gruenbeck, Y, Wong, S, Datta, P, Bateman, G, Jackson, L, Needle, A, Duodu, Y, Oliver, R, Padilla-Harris, C, Barber, M, Esson, D, Brodie, F, McInnes, C, Fotherby, K, Butler, D, Morgan, D, Preece, K, Willberry, A, Dent, M, Hammonds, F, Hunt, J, Vernon, C, O'Kane, D, Faola, F, Lai, P, O'Callaghan, J, Smith, C, Price, C, Lakey, R, Riddell, V, Smith, A, Storey, G, Munshi, S, Buck, A, Clarke, J, Gilzeane, N, Godfrey, M, Keshvara, R, Richardson, C, Roffe, J, Ryan, L, Shelton, F, Sunman, W, Tittle, A, Tomlinson, J, Whittamore, K, Wilkes, G, Owusu-Agyei, P, Temple, N, Mangion, D, Hardwick, A, Netherton, K, Nor, A Mohd, Hyams, B, Norman, S, Persad, N, Ragab, S, Dickson, C, Dube, J, Jinks, E, Knops, K, Wadams, B, Ali, K, Gaylard, J, Spurling, G, Sztriha, L, Ajao, T, Alao, M, Chan, F K, Webster, P, Howard, P, Dobson, T J, Hyatt, L, Sims, D, Cunningham, J, Esisi, B, Cassidy, T, Bokhari, M, McClelland, B, Mokoena, B, Gunathilagan, G, Jones, S, Reader, M, Thomas, G, Tilby, S, Findlay, P, Barrett, F, Leslie, F, Ross, S, Shread, I, Okwera, J, Howe, J, Harrington, F, Courtauld, G, Schofield, C, Donnelly, R, Maddula, M, Scott, J, Beavan, J, Muhidden, K, Memon, I, Clarke, M, Hedstrom, A, Mills, L, Hemsley, A, Bowring, A, Boxall, L, Kingwell, H, Keenan, S, Roughan, C, Manoj, A, Cox, P, Fletcher, G, Lopez, P, Emsley, H, Gregary, B, McLoughlin, A, Raj, S, Roffe, C, Abano, N, Barry, A, Butler, A, Carpio, R, Castro, K, Finney, K, Gomm, S, Hiden, J, Grocott, J, Lyjko, S, Maguire, H, Remegoso, A, Sanyal, R, Stevens, S, Natarajan, I, Chembala, J, Muddegowda, G, Warusevitane, A, Blight, A, Balazikova, O, Lawlor, C, Shaw, L, Button, D, Howcroft, D, Lucas, S, Madigan, B, McCann, S, Dixit, A, Barkat, A, Davis, J, Fawcett, M, Finlay, L, Guy, H, Hays, C, Hogg, V, Horsley, E, Hubbuck, C, Pringle, C, Stevenson, C, Storey, K, Thompson, T, Woodward, S, Banerjee, A, Allcock, C, Merotra, S, Douglass, C, Campbell, E, Jarapa, R, Johnes, M, Keaveney, C, Marsden, T, Naing, Z, Perez, J, Shaw, K, Black, T, Anthony, A, Clarke, C, Paterson, J, Deighton, K, Temlett, E, Blank, C, Doyle, C, Duty, S, Gill, K, Harkness, K, Kamara, C, Richards, E, Elfandi, K, Guyler, P, Harman, P, Khuoge, C, Kunhunny, S, Tysoe, S, Moynihan, B, Adedoyin, T, Chopra, N, Dayal, N, Ghatala, R, Jeyaraj, N, Jones, I, Kennedy, F, Kerin, L, Khanom, N, Lewis, S, Maheswaran, S, Montague, L, Niemierko, M, O'Reilly, J, Trippier, S, Watson, F, Wilkinson, P, Young, E, Dizayee, K, Cochrane, H, O'Connell, J, Mokoena, L, Osborne, E, Nair, A, Greig, J, Jenkins, C, Powell, J, Price, F, Chowdhury, M, Brixey, S, Hunt, L, Rands, N, Rose, G, Stoddart, S, Srinivasan, M, Motherwell, N, Shekhar, R, Fuller, T, Lankester, A, Lingwood, P, Rankin, C, Webb, H, Jupp, B, Bell, J, Hann, G, Longland, B, Ovington, C, Bhaskaran, B, Ayres, G, Bailey, C, Bearne, H, Buxton, J, Fitzell, P, Hilaire, C, Kelly, D, Szabo, S, Tomlin, D, Gamble, E, Charles, B, Kumar, R, Fluskey, T, Mellor, Z, Peters, J, Sutton, V, Kenton, A, Martin, I, Nyabadza, S, Ghosh, S, Henry, M, Kumar, B, Ambulo, C, Crawford, S, Nozedar, T, Platton, M, Cvoro, V, Couser, M, McCormick, K, Wilkinson, D, Javaid, K, Hurdowar, S, Attygalle, T, Sundayi, S, Orugun, O, Crowther, H, Jolly, R, Poultney, U, Azim, A, Krasinska-Chavez, M, White, J, Sengupta, N, Margalef, J, Metiu, M G, Meenakshisundaram, S, Dealing, S, Hargroves, D, Beranova, E, Cowie, L, Rudenko, H, Thomson, A, Verrion, A, Rashed, K, Board, S, Buckley, C, Hayward, D, Jenkins, K, Keeling, E, Rowland-Axe, R, Vickers, C, Wood, D, Lehman, A, Patel, M, Russell, H, Rehman, H, Forrest, D, Farren, P, Bath, Philip M, Woodhouse, Lisa J, Appleton, Jason P, Beridze, Maia, Christensen, Hanne, Dineen, Robert A, Duley, Lelia, England, Timothy J, Flaherty, Katie, Havard, Diane, Heptinstall, Stan, James, Marilyn, Krishnan, Kailash, Markus, Hugh S, Montgomery, Alan A, Pocock, Stuart J, Randall, Marc, Ranta, Annemarei, Robinson, Thompson G, Scutt, Polly, Venables, Graham S, and Sprigg, Nikola

Published
2018
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22. SuperCam Calibration Targets: Design and Development

Author

Manrique, J. A., Lopez-Reyes, G., Cousin, A., Rull, F., Maurice, S., Wiens, R. C., Madsen, M. B., Madariaga, J. M., Gasnault, O., Aramendia, J., Arana, G., Beck, P., Bernard, S., Bernardi, P., Bernt, M. H., Berrocal, A., Beyssac, O., Caïs, P., Castro, C., Castro, K., Clegg, S. M., Cloutis, E., Dromart, G., Drouet, C., Dubois, B., Escribano, D., Fabre, C., Fernandez, A., Forni, O., Garcia-Baonza, V., Gontijo, I., Johnson, J., Laserna, J., Lasue, J., Madsen, S., Mateo-Marti, E., Medina, J., Meslin, P.-Y., Montagnac, G., Moral, A., Moros, J., Ollila, A. M., Ortega, C., Prieto-Ballesteros, O., Reess, J. M., Robinson, S., Rodriguez, J., Saiz, J., Sanz-Arranz, J. A., Sard, I., Sautter, V., Sobron, P., Toplis, M., and Veneranda, M.

Published
2020
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26. O PAPEL DA LITERACIA PARA A SAÚDE E EDUCAÇÃO PARA A SAÚDE NA PROMOÇÃO DA SAÚDE

Author

SABOGA-NUNES, L., primary, MARTINS, R. A. S., additional, FARINELLI, Marta Regina, additional, JULIÃO, Cláudia Helena, additional, ARAGAO, A. S., additional, DUARTE, ALBERTO CARLOS MARQUES, additional, PAVÃO, A. L. B., additional, RUZZI-PEREIRA, Andrea, additional, CARVALHO NETO, C. T., additional, ANDRADE, CARMEN MARIA SILVA MACIEL, additional, BARBOSA, C. A. P., additional, CARDOSO, D., additional, SILVA, D. D., additional, LIMA, E. D., additional, PACHECO, E. A. C., additional, TREVISAN, E. R., additional, CAMARGO, F. C., additional, SOUSA, GILBERTA MARIA FRANÇA, additional, FREITAS, GREGÓRIO MAGNO DE VASCONCELOS DE, additional, PEREIRA, HELDER JOSÉ ALVES DA ROCHA, additional, SILVA, HELENA MARGARIDA OLIVEIRA DA, additional, ELIAS, H. C., additional, SILVA, ISABEL MARIA DOS SANTOS CARVALHO GOMES DA, additional, ARDENGHI, I. C., additional, ALMEIDA, J. M., additional, RODRIGUES, J. O., additional, OLIVEIRA, J. J. A., additional, CASTRO, K. C., additional, FREITAS, LÚCIA DE FÁTIMA MOTA FERREIRA, additional, MORNA, MARIA CLEMENTINA DE FREITAS NÓBREGA, additional, MANO, MARIA DA PIEDADE LIMA LALANDA GONÇALVES, additional, SANTOS, MIRIAM DOS, additional, SOUZA, M. N. S., additional, FREITAS, OTÍLIA MARIA DA SILVA, additional, RIBEIRO, P. M. A., additional, REZENDE, Regina Maura, additional, VASCONCELOS, RITA MARIA CÉSAR SÁ FERNANDES, additional, SEBOLD, R., additional, QUERINO, R. A., additional, and SILVA, T. N., additional

Published
2019
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27. Burning mouth syndrome and Reflux Disease: relationship and clinical implications

Author

Russo, M, Crafa, P, Franceschi, M, Rodriguez-Castro, K, Franzoni, L, Guglielmetti, S, Fiore, W, Di Mario, F, Russo M., Crafa P., Franceschi M., Rodriguez-Castro K. I., Franzoni L., Guglielmetti S., Fiore W., Di Mario F., Russo, M, Crafa, P, Franceschi, M, Rodriguez-Castro, K, Franzoni, L, Guglielmetti, S, Fiore, W, Di Mario, F, Russo M., Crafa P., Franceschi M., Rodriguez-Castro K. I., Franzoni L., Guglielmetti S., Fiore W., and Di Mario F.

Abstract

Background and aim: An association between reflux and burning mouth syndrome (BMS) has been proposed for a long time, although there is little evidence of a connection. Aims of this study were threefold: 1) to investigate the frequency of BMS in a sample of GERD patients showing both typical and atypical symptoms; 2) to measure a non-invasive marker of GERD, i.e. serum Gastrin 17, in a sample of BMS patients; 3) to assess the efficacy of different therapeutical schedules for GERD in BMS patients. Methods: We divided the study in 3 main steps. In step one, we selected 500 consecutive GERD patients to analyze type and frequency of extraesophageal manifestations of reflux disease, including BMS. In step two, we selected 124 consecutive BMS patients and collected data about symptoms presentation and serum gastrin 17 levels. In step three, we performed a follow-up evaluating the efficacy of 3 different drugs on BMS. Results: In step one, 204 patients complained heartburn; 31 pharyngeal globus; 52 chronic cough; 54 pharyngitis; 31 postnasal drip; 56 burning mouth symptoms; 34 noncardiac chest pain; 17 asthma and 21 sleep apnea. In step two, 29 patients had gastrin-17 ≤ 1 pg/L; 64 patients between 1 and 3; and 31 patients ≥ 3. In step three, 49 patients reported slight benefit with PPI, 75 no benefit. 61 patients reported slight benefit with sodium alginate and sodium bi-carbonate, 63 no benefit. 23 reported an almost complete remission with HYCHSA, 26 slight benefits, 33 no benefit. Conclusions: Prevalence of BMS in GERD patients was similar to that reported for chronic chough and pharyngitis. Low levels of Gastrin 17 were found in the majority of BMS patients. Finally, we observed a greater benefit from barrier drugs therapy than from PPI therapy in BMS patients. (www.actabiomedica.it).

Published
2022

28. A Mars 2020 Perseverance SuperCam Perspective on the Igneous Nature of the Máaz Formation at Jezero Crater and Link With Séítah, Mars

Author

Udry, A., Ostwald, A., Sautter, V., Cousin, A., Beyssac, O., Forni, O., Dromart, G., Benzerara, K., Nachon, M., Horgan, B., Mandon, L., Clavé, E., Dehouck, E., Gibbons, E., Alwmark, S., Ravanis, E., Wiens, R. C., Legett, C., Anderson, R., Pilleri, P., Mangold, N., Schmidt, M., Liu, Y., Núñez, J. I., Castro, K., Madariaga, J. M., Kizovski, T., Beck, P., Bernard, S., Bosak, T., Brown, A., Clegg, S., Cloutis, E., Cohen, B., Connell, S., Crumpler, L., Debaille, V., Flannery, D., Fouchet, T., Gabriel, T. S.J., Gasnault, O., Herd, C. D.K., Johnson, J., Manrique, J. A., Maurice, S., McCubbin, F. M., McLennan, S., Ollila, A., Pinet, P., Quantin-Nataf, C., Udry, A., Ostwald, A., Sautter, V., Cousin, A., Beyssac, O., Forni, O., Dromart, G., Benzerara, K., Nachon, M., Horgan, B., Mandon, L., Clavé, E., Dehouck, E., Gibbons, E., Alwmark, S., Ravanis, E., Wiens, R. C., Legett, C., Anderson, R., Pilleri, P., Mangold, N., Schmidt, M., Liu, Y., Núñez, J. I., Castro, K., Madariaga, J. M., Kizovski, T., Beck, P., Bernard, S., Bosak, T., Brown, A., Clegg, S., Cloutis, E., Cohen, B., Connell, S., Crumpler, L., Debaille, V., Flannery, D., Fouchet, T., Gabriel, T. S.J., Gasnault, O., Herd, C. D.K., Johnson, J., Manrique, J. A., Maurice, S., McCubbin, F. M., McLennan, S., Ollila, A., Pinet, P., and Quantin-Nataf, C.

Abstract

The Máaz formation consists of the first lithologies in Jezero crater analyzed by the Mars 2020 Perseverance rover. This formation, investigated from Sols (Martian days) 1 to 201 and from Sols 343 to 382, overlies the Séítah formation (previously described as an olivine-rich cumulate) and was initially suggested to represent an igneous crater floor unit based on orbital analyses. Using SuperCam data, we conducted a detailed textural, chemical, and mineralogical analyses of the Máaz formation and the Content member of the Séítah formation. We conclude that the Máaz formation and the Content member are igneous and consist of different lava flows and/or possibly pyroclastic flows with complex textures, including vesicular and non-vesicular rocks with different grain sizes. The Máaz formation rocks exhibit some of the lowest Mg# (=molar 100 × MgO/MgO + FeO) of all Martian igneous rocks analyzed so far (including meteorites and surface rocks) and show similar basaltic to basaltic-andesitic compositions. Their mineralogy is dominated by Fe-rich augite to possibly ferrosilite and plagioclase, and minor phases such as Fe-Ti oxides and Si-rich phases. They show a broad diversity of both compositions and textures when compared to Martian meteorites and other surface rocks. The different Máaz and Content lava or pyroclastic flows all originate from the same parental magma and/or the same magmatic system, but are not petrogenetically linked to the Séítah formation. The study of returned Máaz samples in Earth-based laboratories will help constrain the formation of these rocks, calibrate Martian crater counting, and overall, improve our understanding of magmatism on Mars.

Published
2023

29. Multi-analytical characterization of an oncoid from a high altitude hypersaline lake using techniques employed in the Mars2020 and Rosalind Franklin missions on Mars

Author

Agencia Estatal de Investigación (España), 0000-0001-8302-8583, 0000-0003-1568-4591, 0000-0002-2609-4485, 0000-0002-7185-2791, 0000-0002-9162-3734, Huidobro, J, Madariaga, J M, Carrizo, D, Laserna, J L, Rull, F, Martínez-Frías, J., Aramendia, J, Sánchez-García, L, García-Gómez, L, Vignale, F A, Farías, M E, Veneranda, M, Población, I, Cabalín, L M, López-Reyes, G, Coloma, L, García-Florentino, C, Arana, G, Castro, K, Delgado, T, Álvarez-Llamas, C, Fortes, F J, Manrique, J A, Agencia Estatal de Investigación (España), 0000-0001-8302-8583, 0000-0003-1568-4591, 0000-0002-2609-4485, 0000-0002-7185-2791, 0000-0002-9162-3734, Huidobro, J, Madariaga, J M, Carrizo, D, Laserna, J L, Rull, F, Martínez-Frías, J., Aramendia, J, Sánchez-García, L, García-Gómez, L, Vignale, F A, Farías, M E, Veneranda, M, Población, I, Cabalín, L M, López-Reyes, G, Coloma, L, García-Florentino, C, Arana, G, Castro, K, Delgado, T, Álvarez-Llamas, C, Fortes, F J, and Manrique, J A

Abstract

In this work, a geological sample of great astrobiological interest was studied through analytical techniques that are currently operating in situ on Mars and others that will operate in the near future. The sample analyzed consisted of an oncoid, which is a type of microbialite, collected in the Salar Carachi Pampa, Argentina. The main peculiarity of microbialites is that they are organo-sedimentary deposits formed by the in situ fixation and precipitation of calcium carbonate due to the growth and metabolic activities of microorganisms. For this reason, the Carachi Pampa oncoid was selected as a Martian analog for astrobiogeochemistry study. In this sense, the sample was characterized by means of the PIXL-like, SuperCam-like and SHERLOC-like instruments, which represent instruments on board the NASA Perseverance rover, and by means of RLS-like and MOMA-like instruments, which represent instruments on board the future ESA Rosalind Franklin rover. It was possible to verify that the most important conclusions and discoveries have been obtained from the combination of the results. Likewise, it was also shown that Perseverance rover-like remote-sensing instruments allowed a first detailed characterization of the biogeochemistry of the Martian surface. With this first characterization, areas of interest for in-depth analysis with Rosalind Franklin-like instruments could be identified. Therefore, from a first remote-sensing elemental identification (PIXL-like instrument), followed by a remote-sensing molecular characterization (SuperCam and SHERLOC-like instruments) and ending with an in-depth microscopic analysis (RLS and MOMA-like instruments), a wide variety of compounds were found. On the one hand, the expected minerals were carbonates, such as aragonite, calcite and high-magnesium calcite. On the other hand, unexpected compounds consisted of minerals related to the Martian/terrestrial surface (feldspars, pyroxenes, hematite) and organic compounds related to the past

Published
2023

32. An updated examination of the perception of barriers for pharmacogenomics implementation and the usefulness of drug/gene pairs in Latin America and the Caribbean

Author

Salas-Hernández, A., Galleguillos, M., Carrasco, M., López-Cortés, A., Redal, M.A., Fonseca-Mendoza, D., Esperón, P., González-Martínez, F., Lares-Asseff, I., Lazarowski, A., Loera-Castañeda, V., Remírez, D., Martínez, M.F., Vargas, R., Rios-Santos, F., Macho, A., Cayún, J.P., Perez, G.R., Gutierrez, C., Cerpa, L.C., Leiva, T., Calfunao, S., Xajil, L., Sandoval, C., Suárez, M., Gonzalez, A., Echeverría-Garcés, G., Sullón-Dextre, L., Cordero-García, E., Morales, A.R., Avendaño, A., Sánchez, E., Bastone, L.C., Lara, C., Zuluaga-Arias, P., Soler, A.M., Da Luz, J., Burgueño-Rodríguez, G., Vital, M., Reyes-Reyes, E., Huaccha, A., Ariza, Y.V., Tzul, N., Rendón, A.L., Serrano, R., Acosta, L., Motta-Pardo, A., Beltrán-Angarita, L., Brand Alarcón, Erika Tatiana, Jiménez, M.A., Hidalgo-Lozada, G.M., Romero-Prado, M.M.J., Escobar-Castro, K., Umaña-Rivas, M., Vivas, J.D., Lagos, P., Martínez, Y.B., Quesada, S., Calfio, C., Arias, M.L., Lavanderos, M.A., Cáceres, D.D., Salazar-Granara, A., Varela, N.M., Quiñones, L.A., and On behalf of the RELIVAF NETWORK

Subjects
Pharmacology, Genes, Preparaciones Farmacéuticas, Precision medicine, Farmacogenética, Medicina de Precisión, Pharmacology (medical), Pharmacogenomics, Barriers, Gene/drug pair
Abstract

Pharmacogenomics (PGx) is considered an emergent field in developing countries. Research on PGx in the Latin American and the Caribbean (LAC) region remains scarce, with limited information in some populations. Thus, extrapolations are complicated, especially in mixed populations. In this paper, we reviewed and analyzed pharmacogenomic knowledge among the LAC scientific and clinical community and examined barriers to clinical application. We performed a search for publications and clinical trials in the field worldwide and evaluated the contribution of LAC. Next, we conducted a regional structured survey that evaluated a list of 14 potential barriers to the clinical implementation of biomarkers based on their importance. In addition, a paired list of 54 genes/drugs was analyzed to determine an association between biomarkers and response to genomic medicine. This survey was compared to a previous survey performed in 2014 to assess progress in the region. The search results indicated that Latin American and Caribbean countries have contributed 3.44% of the total publications and 2.45% of the PGx-related clinical trials worldwide thus far. A total of 106 professionals from 17 countries answered the survey. Six major groups of barriers were identified. Despite the region’s continuous efforts in the last decade, the primary barrier to PGx implementation in LAC remains the same, the “need for guidelines, processes, and protocols for the clinical application of pharmacogenetics/pharmacogenomics”. Cost-effectiveness issues are considered critical factors in the region. Items related to the reluctance of clinicians are currently less relevant. Based on the survey results, the highest ranked (96%–99%) gene/drug pairs perceived as important were CYP2D6/tamoxifen, CYP3A5/tacrolimus, CYP2D6/opioids, DPYD/fluoropyrimidines, TMPT/thiopurines, CYP2D6/tricyclic antidepressants, CYP2C19/tricyclic antidepressants, NUDT15/thiopurines, CYP2B6/efavirenz, and CYP2C19/clopidogrel. In conclusion, although the global contribution of LAC countries remains low in the PGx field, a relevant improvement has been observed in the region. The perception of the usefulness of PGx tests in biomedical community has drastically changed, raising awareness among physicians, which suggests a promising future in the clinical applications of PGx in LAC.

Published
2023
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39. Principal component analysis on the supercam-libs spectra of rock targets in the first 640 sols in jezero crater

Author

Castro, K., Arana, G., Población, I., Clegg, S.M., Gibbons, E.F., Manrique, J.-A., Gasda, P., Udry, A., Aramendia, J., Madariaga, J.M., Veneranda, M., Anderson, R.B., López-Reyes, G., Cousin, A., Forni, O., Lasue, J., Legett IV, C., Maurice, S., Ollila, A.M., Wiens, R.C., Beyssac, O., Brown, A.J., Clavé, E., Dehouck, E., Fouchet, T., Gasnault, O., Lanza, N., Laserna, J., Martinez-Frias, J., Pilleri, P., Royer, C., Rull, F., Team, The Supercam, University of the Basque Country/Euskal Herriko Unibertsitatea (UPV/EHU), Los Alamos National Laboratory (LANL), McGill University = Université McGill [Montréal, Canada], Universidad de Valladolid [Valladolid] (UVa), United States Geological Survey (USGS), Institut de recherche en astrophysique et planétologie (IRAP), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Purdue University [West Lafayette], Bioinformatique et BioPhysique [IMPMC] (IMPMC_BIBIP), Institut de minéralogie, de physique des matériaux et de cosmochimie (IMPMC), Muséum national d'Histoire naturelle (MNHN)-Institut de recherche pour le développement [IRD] : UR206-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Muséum national d'Histoire naturelle (MNHN)-Institut de recherche pour le développement [IRD] : UR206-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Université de Bordeaux (UB), Laboratoire de Géologie de Lyon - Terre, Planètes, Environnement (LGL-TPE), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut national des sciences de l'Univers (INSU - CNRS)-Université Jean Monnet - Saint-Étienne (UJM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'études spatiales et d'instrumentation en astrophysique = Laboratory of Space Studies and Instrumentation in Astrophysics (LESIA), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Universidad de Málaga [Málaga] = University of Málaga [Málaga], Instituto de Geociencias [Madrid] (IGEO), Universidad Complutense de Madrid = Complutense University of Madrid [Madrid] (UCM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), and Lunar and Planetary Institute

Subjects
[SDU.STU.PL]Sciences of the Universe [physics]/Earth Sciences/Planetology, [SDU]Sciences of the Universe [physics], [SDU.ASTR.EP]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Earth and Planetary Astrophysics [astro-ph.EP]
Abstract

International audience

Published
2023

40. Petrological traverse of the olivine cumulate Séítah formation at Jezero crater, Mars : A perspective from SuperCam onboard Perseverance

Author

Beyssac, O., Forni, O., Cousin, A., Udry, A., Kah, L.C., Mandon, L., Clavé, E., Liu, Y., Poulet, F., Quantin Nataf, C., Gasnault, O., Johnson, J., Benzerara, K., Beck, P., Dehouck, E., Mangold, N., Alvarez Llamas, C., Anderson, R., Arana, G., Barnes, R., Bernard, S., Bosak, T., Brown, A.J., Castro, K., Chide, B., Clegg, S., Cloutis, E., Fouchet, T., Gabriel, T., Gupta, S., Lacombe, G., Lasue, J., Le Mouelic, S., Lopez‐Reyes, G., Madariaga, J.M., McCubbin, F.M., McLennan, S., Manrique, J.A., Meslin, P.Y., Montmessin, F., Núñez, J., Ollila, A.M., Ostwald, A., Pilleri, P., Pinet, P., Royer, C., Sharma, S.K., Schröder, Susanne, Simon, J.I., Toplis, M.J., Veneranda, M., Willis, P.A., Maurice, S., Wiens, R.C., Institut de minéralogie, de physique des matériaux et de cosmochimie (IMPMC), Muséum national d'Histoire naturelle (MNHN)-Institut de recherche pour le développement [IRD] : UR206-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut de recherche en astrophysique et planétologie (IRAP), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Department of Geoscience [Las Vegas], University of Nevada [Las Vegas] (WGU Nevada), Department of Earth and Planetary Sciences [Knoxville], The University of Tennessee [Knoxville], Laboratoire d'études spatiales et d'instrumentation en astrophysique = Laboratory of Space Studies and Instrumentation in Astrophysics (LESIA), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Centre d'Etudes Lasers Intenses et Applications (CELIA), Université de Bordeaux (UB)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS), Jet Propulsion Laboratory (JPL), NASA-California Institute of Technology (CALTECH), Institut d'astrophysique spatiale (IAS), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), Laboratoire de Géologie de Lyon - Terre, Planètes, Environnement (LGL-TPE), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut national des sciences de l'Univers (INSU - CNRS)-Université Jean Monnet - Saint-Étienne (UJM)-Centre National de la Recherche Scientifique (CNRS), Johns Hopkins University Applied Physics Laboratory [Laurel, MD] (APL), Laboratoire de Planétologie et Géosciences - Angers (LPG-ANGERS), Laboratoire de Planétologie et Géosciences [UMR_C 6112] (LPG), Université d'Angers (UA)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Nantes université - UFR des Sciences et des Techniques (Nantes univ - UFR ST), Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Université d'Angers (UA)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Nantes université - UFR des Sciences et des Techniques (Nantes univ - UFR ST), Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Department of Analytical Chemistry [Malaga], Universidad de Málaga [Málaga] = University of Málaga [Málaga], Astrogeology Science Center [Flagstaff], United States Geological Survey [Reston] (USGS), Department of Analytical Chemistry [Leioa], University of the Basque Country/Euskal Herriko Unibertsitatea (UPV/EHU), Department of Earth Science and Engineering [Imperial College London], Imperial College London, Department of Earth, Atmospheric and Planetary Sciences [MIT, Cambridge] (EAPS), Massachusetts Institute of Technology (MIT), Plancius Research LLC, Los Alamos National Laboratory (LANL), University of Winnipeg, Laboratoire Energie Signal Images et Automatique [Univ Ngaoundéré] (LESIA), Université de Ngaoundéré/University of Ngaoundéré [Cameroun] (UN), Universidad de Valladolid [Valladolid] (UVa), NASA Johnson Space Center (JSC), NASA, Department of Geosciences [Stony Brook], Stony Brook University [SUNY] (SBU), State University of New York (SUNY)-State University of New York (SUNY), PLANETO - LATMOS, Laboratoire Atmosphères, Milieux, Observations Spatiales (LATMOS), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Hawaii Institute of Geophysics and Planetology (HIGP), University of Hawai‘i [Mānoa] (UHM), DLR Institute of Optical Sensor Systems, Deutsches Zentrum für Luft- und Raumfahrt [Berlin] (DLR), Department of Earth, Atmospheric, and Planetary Sciences [West Lafayette] (EAPS), and Purdue University [West Lafayette]

Subjects
spectroscopy, LIBS, m2020, Mars, Perseverance, Jezero, Jezero crater, reflectance spectroscopy, in-situ, [SDU]Sciences of the Universe [physics], rover, Seitah, VisIR, Raman, in-situ science
Abstract

International audience; Séítah is the stratigraphically lowest formation visited by Perseverance in the Jezero crater floor. We present the data obtained by SuperCam: texture by imagery, chemistry by LIBS, and mineralogy by VISIR and Raman spectroscopy. The Séítah formation consists of igneous, weakly altered, rocks dominated by millimeter-size grains of olivine with the presence of low-Ca and high-Ca pyroxenes, and other primary minerals (e.g., plagioclase, Cr-Fe-Ti oxides, phosphates). Along a ∼140 m long section in Séítah, SuperCam analyses showed evidence of geochemical and mineralogical variations, from the contact with the overlying Máaz formation, going deeper in the formation. Bulk rock and olivine Mg#, grain size, olivine content increase gradually further from the contact. Along the section, olivine Mg# are not in equilibrium with the bulk rock Mg#, indicating local olivine accumulation. These observations are consistent with Séítah being the deep ultramafic member of a cumulate series derived from the fractional crystallization and slow cooling of the parent magma at depth. Possible magmatic processes and exhumation mechanisms of Séítah are discussed. Séítah rocks show some affinity with some rocks at Gusev crater, and with some martian meteorites suggesting that such rocks are not rare on the surface of Mars. Séítah is part of the Nili Fossae regional olivine-carbonate unit observed from orbit. Future exploration of Perseverance on the rim and outside of the crater will help determine if the observations from the crater floor can be extrapolated to the whole unit, or if this unit is composed of distinct sub-units with various origins.

Published
2023
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43. Developing Tailored Data Combination Strategies to Optimize the SuperCam Classification of Carbonate Phases on Mars.

Author

Veneranda, M., Manrique, J. A., Lopez‐Reyes, G., Julve‐Gonzalez, S., Rull, F., Alvarez Llamas, C., Delgado Pérez, T., Gibbons, E., Clavé, E., Cloutis, E., Huidobro, J., Castro, K., Madariaga, J. M., Randazzo, N., Brown, A., Willis, P., Maurice, S., and Wiens, R. C.

Subjects
LASER-induced breakdown spectroscopy, CARBONATE minerals, FISHER discriminant analysis, MARS (Planet), PRINCIPAL components analysis, DISCRIMINANT analysis, GEOLOGICAL modeling, NAIVE Bayes classification
Abstract

The SuperCam instrument onboard the Mars 2020 Perseverance rover investigates Martian geological targets by a combination of multiple spectroscopic techniques. As Raman, Visible‐Infrared Spectroscopy, and Laser‐Induced Breakdown Spectroscopy (LIBS) spectra deliver complementary information about the interrogated sample, the multivariate analysis of combined spectroscopic data sets is here proposed as a tool to optimize the SuperCam capability to discriminate mineral phases on Mars. For this purpose, the laboratory study of carbonate phases within the Ca‐Mg‐Fe ternary system were selected as representative case of study. After the characterization of model samples, the discrimination capability of mono analytical Raman, VISIR, and LIBS data sets was evaluated by applying a chemometric approach based on the combination of principal component analysis (for sample clustering) and Linear Discriminant Analysis (for mineral classification). Afterward, the low‐level combination (LL) of Raman, VISIR, and LIBS data was achieved by concatenating their spectra into a single data matrix. The mineral classification achieved by LL data sets outperformed the mono analytical ones, thus proving the complementarity between molecular and elemental spectroscopic techniques. Mineral classification was further improved by using a mid‐level data combination strategy. After evaluating benefits and limitations afforded by the proposed combination strategies, future developments are finally outlined. As such, the final objective of this research line is to develop a classification model based on data combination to optimize the capability of SuperCam in discriminating relevant minerals on Mars, this being a key requirement for the selection of the optimal targets to be cached for the future Mars Sample Return Mission. Plain Language Summary: The SuperCam instrument onboard the Perseverance rover is capable of analyzing Martian rocks and soils by a combination of Laser‐Induced Breakdown Spectroscopy (LIBS), Raman and Visible‐Infrared Spectroscopy (VISIR). Learning from terrestrial applications, the complementary information provided by the three spectroscopic techniques can be correlated to obtain a more accurate interpretation of the analyzed target. This approach could be particularly useful to discriminate carbonates, which are interesting minerals where to look for traces of past life. Having this in mind, several carbonate samples have been analyzed with laboratory Raman, LIBS, and VISIR instrument. After evaluating the advantages and limitations of each technique, their data were merged by using low‐level and mid‐level strategies that were successfully used previous works. This work proved that, when spectra are combined, the discrimination of carbonate phases is more accurate than when each technique is interpreted separately. This suggests the scientific results obtained by SuperCam on Mars could benefit from the development of tailored classification models based on data combination. Key Points: Data combination of Raman, Visible‐Infrared Spectroscopy, and Laser‐Induced Breakdown Spectroscopy spectra collected by SuperCam is proposedLow‐ and mid‐level data combination strategies based on principal component analysis (discrimination) + PC‐Linear Discriminant Analysis (classification are evaluated and compared)The low‐level combination method outperformed the mono analytical discrimination. The mid‐level one further improved the results [ABSTRACT FROM AUTHOR]

Published
2023
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49. In situ recording of Mars soundscape

Author

Maurice, S., Chide, B., Murdoch, N., Lorenz, R. D., Mimoun, D., Wiens, R. C., Stott, A., Jacob, X., Bertrand, T., Montmessin, F., Lanza, N. L., Alvarez-Llamas, C., Angel, S. M., Aung, M., Balaram, J., Beyssac, O., Cousin, A., Delory, G., Forni, O., Fouchet, T., Gasnault, O., Grip, H., Hecht, M., Hoffman, J., Laserna, J., Lasue, J., Maki, J., McClean, J., Meslin, P.-Y., Le Mouélic, S., Munguira, A., Newman, C. E., Rodríguez Manfredi, J. A., Moros, J., Ollila, A., Pilleri, P., Schröder, S., de la Torre Juárez, M., Tzanetos, T., Stack, K. M., Farley, K., Williford, K., Acosta-Maeda, T., Anderson, R. B., Applin, D. M., Arana, G., Bassas-Portus, M., Beal, R., Beck, P., Benzerara, K., Bernard, S., Bernardi, P., Bosak, T., Bousquet, B., Brown, A., Cadu, A., Caïs, P., Castro, K., Clavé, E., Clegg, S. M., Cloutis, E., Connell, S., Debus, A., Dehouck, E., Delapp, D., Donny, C., Dorresoundiram, A., Dromart, G., Dubois, B., Fabre, C., Fau, A., Fischer, W., Francis, R., Frydenvang, J., Gabriel, T., Gibbons, E., Gontijo, I., Johnson, J. R., Kalucha, H., Kelly, E., Knutsen, E. W., Lacombe, G., Legett, C., Leveille, R., Lewin, E., Lopez-Reyes, G., Lorigny, E., Madariaga, J. M., Madsen, M., Madsen, S., Mandon, L., Mangold, N., Mann, M., Manrique, J.-A., Martinez-Frias, J., Mayhew, L. E., McConnochie, T., McLennan, S. M., Melikechi, N., Meunier, F., Montagnac, G., Mousset, V., Nelson, T., Newell, R. T., Parot, Y., Pilorget, C., Pinet, P., Pont, G., Poulet, F., Quantin-Nataf, C., Quertier, B., Rapin, W., Reyes-Newell, A., Robinson, S., Rochas, L., Royer, C., Rull, F., Sautter, V., Sharma, S., Shridar, V., Sournac, A., Toplis, M., Torre-Fdez, I., Turenne, N., Udry, A., Veneranda, M., Venhaus, D., Vogt, D., Willis, P., Maurice, S., Chide, B., Murdoch, N., Lorenz, R. D., Mimoun, D., Wiens, R. C., Stott, A., Jacob, X., Bertrand, T., Montmessin, F., Lanza, N. L., Alvarez-Llamas, C., Angel, S. M., Aung, M., Balaram, J., Beyssac, O., Cousin, A., Delory, G., Forni, O., Fouchet, T., Gasnault, O., Grip, H., Hecht, M., Hoffman, J., Laserna, J., Lasue, J., Maki, J., McClean, J., Meslin, P.-Y., Le Mouélic, S., Munguira, A., Newman, C. E., Rodríguez Manfredi, J. A., Moros, J., Ollila, A., Pilleri, P., Schröder, S., de la Torre Juárez, M., Tzanetos, T., Stack, K. M., Farley, K., Williford, K., Acosta-Maeda, T., Anderson, R. B., Applin, D. M., Arana, G., Bassas-Portus, M., Beal, R., Beck, P., Benzerara, K., Bernard, S., Bernardi, P., Bosak, T., Bousquet, B., Brown, A., Cadu, A., Caïs, P., Castro, K., Clavé, E., Clegg, S. M., Cloutis, E., Connell, S., Debus, A., Dehouck, E., Delapp, D., Donny, C., Dorresoundiram, A., Dromart, G., Dubois, B., Fabre, C., Fau, A., Fischer, W., Francis, R., Frydenvang, J., Gabriel, T., Gibbons, E., Gontijo, I., Johnson, J. R., Kalucha, H., Kelly, E., Knutsen, E. W., Lacombe, G., Legett, C., Leveille, R., Lewin, E., Lopez-Reyes, G., Lorigny, E., Madariaga, J. M., Madsen, M., Madsen, S., Mandon, L., Mangold, N., Mann, M., Manrique, J.-A., Martinez-Frias, J., Mayhew, L. E., McConnochie, T., McLennan, S. M., Melikechi, N., Meunier, F., Montagnac, G., Mousset, V., Nelson, T., Newell, R. T., Parot, Y., Pilorget, C., Pinet, P., Pont, G., Poulet, F., Quantin-Nataf, C., Quertier, B., Rapin, W., Reyes-Newell, A., Robinson, S., Rochas, L., Royer, C., Rull, F., Sautter, V., Sharma, S., Shridar, V., Sournac, A., Toplis, M., Torre-Fdez, I., Turenne, N., Udry, A., Veneranda, M., Venhaus, D., Vogt, D., and Willis, P.

Abstract

Prior to the Perseverance rover landing, the acoustic environment of Mars was unknown. Models predicted that: (i) atmospheric turbulence changes at centimeter scales or smaller at the point where molecular viscosity converts kinetic energy into heat1, (ii) the speed of sound varies at the surface with frequency, and (iii) high frequency waves are strongly attenuated with distance in CO₂. However, theoretical models were uncertain because of a lack of experimental data at low pressure, and the difficulty to characterize turbulence or attenuation in a closed environment. Here using Perseverance microphone recordings, we present the first characterization of Mars’ acoustic environment and pressure fluctuations in the audible range and beyond, from 20 Hz to 50 kHz. We find that atmospheric sounds extend measurements of pressure variations down to 1,000 times smaller scales than ever observed before, revealing a dissipative regime extending over 5 orders of magnitude in energy. Using point sources of sound (Ingenuity rotorcraft, laser-induced sparks), we highlight two distinct values for the speed of sound that are ~10 m/s apart below and above 240 Hz, a unique characteristic of low-pressure CO₂-dominated atmosphere. We also provide the acoustic attenuation with distance above 2 kHz, allowing us to elucidate the large contribution of the CO₂ vibrational relaxation in the audible range. These results establish a ground truth for modelling of acoustic processes, which is critical for studies in atmospheres like Mars and Venus ones.

Published
2022

50. Homogeneity assessment of the SuperCam calibration targets onboard rover perseverance

Author

Madariaga, J. M., Aramendia, J., Arana, G., Castro, K., Gomez-Nubla, L., de Vallejuelo, S. Fdez-Ortiz, Garcia-Florentino, C., Maguregui, M., Manrique, J. A., Lopez-Reyes, G., Moros, J., Cousin, A., Maurice, S., Ollila, A. M., Wiens, R. C., Rull, F., Laserna, J., Garcia-Baonza, V., Madsen, M. B., Forni, O., Lasue, J., Clegg, S. M., Robinson, S., Bernardi, P., Brown, A. J., Cais, P., Martinez-Frias, J., Beck, P., Bernard, S., Bernt, M. H., Beyssac, O., Cloutis, E., Drouet, C., Dromart, G., Dubois, B., Fabre, C., Gasnault, O., Gontijo, I., Johnson, J. R., Medina, J., Meslin, P. -Y., Montagnac, G., Sautter, V., Sharma, S. K., Veneranda, M., Willis, P. A., Madariaga, J. M., Aramendia, J., Arana, G., Castro, K., Gomez-Nubla, L., de Vallejuelo, S. Fdez-Ortiz, Garcia-Florentino, C., Maguregui, M., Manrique, J. A., Lopez-Reyes, G., Moros, J., Cousin, A., Maurice, S., Ollila, A. M., Wiens, R. C., Rull, F., Laserna, J., Garcia-Baonza, V., Madsen, M. B., Forni, O., Lasue, J., Clegg, S. M., Robinson, S., Bernardi, P., Brown, A. J., Cais, P., Martinez-Frias, J., Beck, P., Bernard, S., Bernt, M. H., Beyssac, O., Cloutis, E., Drouet, C., Dromart, G., Dubois, B., Fabre, C., Gasnault, O., Gontijo, I., Johnson, J. R., Medina, J., Meslin, P. -Y., Montagnac, G., Sautter, V., Sharma, S. K., Veneranda, M., and Willis, P. A.

Abstract

The SuperCam instrument, onboard the Perseverance rover (Mars 2020 mission) is designed to perform remote analysis on the Martian surface employing several spectroscopic techniques such as Laser Induced Breakdown Spectroscopy (LIBS), Time-Resolved Raman (TRR), Time-Resolved Fluorescence (TRF) and Visible and Infrared (VISIR) reflectance. In addition, SuperCam also acquires high-resolution images using a color remote micro imager (RMI) as well as sounds with its microphone. SuperCam has three main subsystems, the Mast Unit (MU) where the laser for chemical analysis and collection optics are housed, the Body Unit (BU) where the different spectrometers are located inside the rover, and the SuperCam Calibration Target (SCCT) located on the rover's deck to facilitate calibration tests at similar ambient conditions as the analyzed samples. To perform adequate calibrations on Mars, the 22 mineral samples included in the complex SCCT assembly must have a very homogeneous distribution of major and minor elements. The analysis and verification of such homogeneity for the 5-6 replicates of the samples included in the SCCT has been the aim of this work. To verify the physic chemical homogeneity of the calibration targets, micro Energy Dispersive X-ray Fluorescence (EDXRF) imaging was first used on the whole surface of the targets, then the relative abundances of the detected elements were computed on 20 randomly distributed areas of 100 x 100 mu m. For those targets showing a positive Raman response, micro-Raman spectroscopy imaging was performed on the whole surface of the targets at a resolution of 100 x 100 mu m. The %RSD values (percent of relative standard deviation of mean values) for the major elements measured with EDXRF were compared with similar values obtained by two independent LIBS set-ups at spot sizes of 300 mu m in diameter. The statistical analysis showed which elements were homogeneously distributed in the 22 mineral targets of the SCCT, providing their unc

Published
2022

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