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Objective: To describe the available scientific evidence in relation acute onset motor neurological disorders associated with SARS-CoV-2, due to the modifications it represents in the differential diagnosis in children and adolescents. Acquisition of the evidence: The search for articles was held from December 2019 to August 2020, in Medline database. A total of 95 papers in Spanish and English language were consulted. The keywords used were Coronavirus, Covid 19, Neurology; Motor disorders. Results: The neurological manifestations described in the literature associated with the COVID-19 may include acute motor disorders. Therefore, from the pandemic, the differential diagnosis of children and adolescents with muscle weakness or acute starting difficulties includes, as a possible cause, SARS-COV-2. Conclusion: Motor manifestations of neurological origin and acute onset associated with COVID-19 have been described, including myelitis, myositis, polyneuropathies and Guillain-Barre syndrome, which implies modifications in the differential diagnosis in children with acute motor disorders. [ABSTRACT FROM AUTHOR]

Objective: To assess the importance of the association of visceromegaly and early-onset external ophthalmoplegia, in patients with neurodevelopmental disorders, for the diagnosis of the neuropathic form of Gaucher disease. Clinical case report: A six-month-old infant was admitted for showing global neurodevelopmental involvement, microcephaly, frequent posture of neck and trunk hyperextension (opisthotonos), recurrent cyanosis crises, hepatomegaly, splenomegaly, and evident limitation of bilateral extrinsic ocular motility. Furthermore, delayed ossification was evident in the patient. The existence of hepatosplenomegaly and limitation of bilateral extrinsic ocular motility were decisive manifestations in the clinical diagnosis, although initially there were doubts regarding neurodevelopmental involvement (delay vs. regression). However, the determination of L444P mutation of GBA1 gene allowed the definitive diagnosis. Conclusions: The presence of visceromegaly and early-onset bilateral external ophthalmoplegia, in patients with neurodevelopmental disorders, are manifestations that suggest Gaucher disease neuropathic form (type 2). These patients may have atypical manifestations such as neurodevelopmental delay and bone involvement. [ABSTRACT FROM AUTHOR]