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5. Hypervirulent Klebsiella pneumoniae Strains Modulate Human Dendritic Cell Functions and Affect TH1/TH17 Response

Author

Nicolò, Sabrina, primary, Mattiuz, Giorgio, additional, Antonelli, Alberto, additional, Arena, Fabio, additional, Di Pilato, Vincenzo, additional, Giani, Tommaso, additional, Baccani, Ilaria, additional, Clemente, Ann Maria, additional, Castronovo, Giuseppe, additional, Tanturli, Michele, additional, Cozzolino, Federico, additional, Rossolini, Gian Maria, additional, and Torcia, Maria Gabriella, additional

Published
2022
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6. mcr-1 Gene Expression Modulates the Inflammatory Response of Human Macrophages to Escherichia coli

Author

Mattiuz, Giorgio, primary, Nicolò, Sabrina, additional, Antonelli, Alberto, additional, Giani, Tommaso, additional, Baccani, Ilaria, additional, Cannatelli, Antonio, additional, Clemente, Ann Maria, additional, Castronovo, Giuseppe, additional, Tanturli, Michele, additional, Cozzolino, Federico, additional, Rossolini, Gian Maria, additional, and Torcia, Maria Gabriella, additional

Published
2020
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7. Young human cholinergic neurons respond to physiological regulators and improve cognitive symptoms in an animal model of Alzheimer’s disease

Author

Morelli, Annamaria, Sarchielli, Erica, Guarnieri, Giulia, Coppi, Elisabetta, Pantano, Daniela, Comeglio, Paolo, Nardiello, Pamela, Pugliese, Anna M., Ballerini, Lara, Matucci, Rosanna, Ambrosini, Stefano, Castronovo, Giuseppe, Rosa, Valente, Mazzanti, Benedetta, Sandra, Bucciantini, Maggi, Mario, Casamenti, Fiorella, Gallina, Pasquale, and Vannelli, Gabriella B.

Subjects
nucleus basalis of Meynert, cell-based therapy, NGF, estrogen receptors, primary cilium, cholinergic receptors
Published
2017

8. Young Human Cholinergic Neurons Respond to Physiological Regulators and Improve Cognitive Symptoms in an Animal Model of Alzheimer’s Disease

Author

Morelli, Annamaria, primary, Sarchielli, Erica, additional, Guarnieri, Giulia, additional, Coppi, Elisabetta, additional, Pantano, Daniela, additional, Comeglio, Paolo, additional, Nardiello, Pamela, additional, Pugliese, Anna M., additional, Ballerini, Lara, additional, Matucci, Rosanna, additional, Ambrosini, Stefano, additional, Castronovo, Giuseppe, additional, Valente, Rosa, additional, Mazzanti, Benedetta, additional, Bucciantini, Sandra, additional, Maggi, Mario, additional, Casamenti, Fiorella, additional, Gallina, Pasquale, additional, and Vannelli, Gabriella B., additional

Published
2017
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9. Characterization of cervico-vaginal microbiota in women developing persistent high-risk Human Papillomavirus infection

Author

Di Paola, Monica, primary, Sani, Cristina, additional, Clemente, Ann Maria, additional, Iossa, Anna, additional, Perissi, Eloisa, additional, Castronovo, Giuseppe, additional, Tanturli, Michele, additional, Rivero, Damariz, additional, Cozzolino, Federico, additional, Cavalieri, Duccio, additional, Carozzi, Francesca, additional, De Filippo, Carlotta, additional, and Torcia, Maria Gabriella, additional

Published
2017
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10. Differential Th17 response induced by the two clades of the pandemic ST258 Klebsiella pneumoniae clonal lineages producing KPC-type carbapenemase

Author

Clemente, Ann Maria, primary, Castronovo, Giuseppe, additional, Antonelli, Alberto, additional, D’Andrea, Marco Maria, additional, Tanturli, Michele, additional, Perissi, Eloisa, additional, Paccosi, Sara, additional, Parenti, Astrid, additional, Cozzolino, Federico, additional, Rossolini, Gian Maria, additional, and Torcia, Maria Gabriella, additional

Published
2017
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11. Differences in Inflammatory Response Induced by Two Representatives of Clades of the Pandemic ST258 Klebsiella pneumoniae Clonal Lineage Producing KPC-Type Carbapenemases

Author

Castronovo, Giuseppe, primary, Clemente, Ann Maria, additional, Antonelli, Alberto, additional, D’Andrea, Marco Maria, additional, Tanturli, Michele, additional, Perissi, Eloisa, additional, Paccosi, Sara, additional, Parenti, Astrid, additional, Cozzolino, Federico, additional, Rossolini, Gian Maria, additional, and Torcia, Maria Gabriella, additional

Published
2017
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13. Modulation of the Immune and Inflammatory Responses by Plasmodium falciparum Schizont Extracts: Role of Myeloid Dendritic Cells in Effector and Regulatory Functions of CD4 + Lymphocytes

Author

Clemente, Ann Maria, primary, Fadigati, Giulia, additional, Caporale, Roberto, additional, Marchese, Damiano G., additional, Castronovo, Giuseppe, additional, Sannella, Anna Rosa, additional, Severini, Carlo, additional, Verra, Federica, additional, Garaci, Enrico, additional, Cozzolino, Federico, additional, and Torcia, Maria Gabriella, additional

Published
2013
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14. Hypervirulent Klebsiella pneumoniae Strains Modulate Human Dendritic Cell Functions and Affect T H 1/T H 17 Response.

Author

Nicolò, Sabrina, Mattiuz, Giorgio, Antonelli, Alberto, Arena, Fabio, Di Pilato, Vincenzo, Giani, Tommaso, Baccani, Ilaria, Clemente, Ann Maria, Castronovo, Giuseppe, Tanturli, Michele, Cozzolino, Federico, Rossolini, Gian Maria, and Torcia, Maria Gabriella

Subjects
CELL physiology, KLEBSIELLA pneumoniae, MUCOUS membranes, IMMUNE response, PHAGOCYTOSIS
Abstract

Hypervirulent Klebsiella pneumoniae (Hv-Kp) strains have emerged as pathogens causing life-threatening, invasive disease even in immunocompetent hosts. Systemic dissemination usually occurs following perturbations of the gut microbiota and is facilitated by Hv-Kp resistance to phagocytosis and complement activity. Hv-Kp are usually associated with K1 or K2 capsular types, produce several iron uptake systems (e.g., aerobactin and salmochelin) and are often but not invariably, capsular material hyper-producers (hypermucoviscous phenotype: HMV). Whether Hv-Kp escape the immune response at mucosal site is unknown. In this work, we studied the effects of Hv-Kp on human dendritic cells (DCs), central players of the IL-23/IL-17 and IL-12/IFN-γ axis at mucosal sites, essential for pathogen clearance. Four Hv-Kp and HMV strains were selected and their activity on DC maturation and cytokine production was compared to that of non-virulent Kp strains with classic or HMV phenotypes. While the maturation process was equally induced by all Kp strains, significant differences between virulent and non-virulent strains were found in the expression of genes for cytokines involved in T-cell activation and differentiation. The non-virulent KP04C62 and the classic Kp, KPC157 induced high expression of TH1 (IL-12p70 and TNFα) and TH17 cytokines (IL-23, IL-1β and IL-6), while Hv-Kp poorly activated these cytokine genes. Moreover, conditioned media from DCs cultured with non-virulent Kp, either classical or hypercapsulated, induced the activation of IL-17 and IFN-γ genes in preactivated CD4+-cells suggesting their TH17/TH1 differentiation. Conditioned media from Hv-Kp poorly activated IL-17 and IFN-γ genes. In summary, our data indicate that Hv-Kp interfere with DC functions and T-cell differentiation and suggest that the escape from the IL-23/IL-17 and IL-12/IFN-γ axes may contribute to pathogen dissemination in immunocompetent hosts. [ABSTRACT FROM AUTHOR]

Published
2022
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15. Modulation of the Immune and Inflammatory Responses by Plasmodium falciparumSchizont Extracts: Role of Myeloid Dendritic Cells in Effector and Regulatory Functions of CD4+Lymphocytes

Author

Clemente, Ann Maria, Fadigati, Giulia, Caporale, Roberto, Marchese, Damiano G., Castronovo, Giuseppe, Sannella, Anna Rosa, Severini, Carlo, Verra, Federica, Garaci, Enrico, Cozzolino, Federico, and Torcia, Maria Gabriella

Abstract

ABSTRACTThe optimal immune response to malaria infection comprises rapid induction of inflammatory responses promptly counteracted by regulatory mechanisms to prevent immunopathology. To evaluate the role of dendritic cells (DC) in the balance of parasite-induced inflammatory/anti-inflammatory mechanisms, we studied the activity of monocyte-derived dendritic cells (MDDC), previously exposed to soluble extracts of Plasmodium falciparum-infected red blood cells (PfSE), in the differentiation of CD4 cells isolated from donors never exposed to malaria infection. We show that MDDC exposed to PfSE are extremely efficient to induce a contemporary differentiation of TH1 effector cells and T regulatory (Treg) cells in CD4 T cells even when exposed to low concentrations of parasitic extracts. Treg cells induced by MDDC infected with PfSE (MDDC-PfSE) produce transforming growth factor beta (TGF-ß) and interleukin 10 (IL-10) and are endowed with strong suppressive properties. They also show phenotypical and functional peculiarities, such as the contemporary expression of markers of Treg and TH1 differentiation and higher sensitivity to TLR4 ligands both inducing an increasing production of suppressive cytokines. On the whole, our data indicate that MDDC exposed to PfSE orchestrate a well-balanced immune response with timely differentiation of TH1 and Treg cells in CD4 cells from nonimmune donors and suggest that, during the infection, the role of MDCC could be particularly relevant in low-parasitemia conditions.

Published
2013
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16. mcr-1Gene Expression Modulates the Inflammatory Response of Human Macrophages to Escherichia coli

Author

Mattiuz, Giorgio, Nicolò, Sabrina, Antonelli, Alberto, Giani, Tommaso, Baccani, Ilaria, Cannatelli, Antonio, Clemente, Ann Maria, Castronovo, Giuseppe, Tanturli, Michele, Cozzolino, Federico, Rossolini, Gian Maria, and Torcia, Maria Gabriella

Abstract

MCR-1 is a plasmid-encoded phosphoethanolamine transferase able to modify the lipid A structure. It confers resistance to colistin and was isolated from human, animal, and environmental strains of Enterobacteriaceae, raising serious global health concerns. In this paper, we used recombinant mcr-1-expressing Escherichia colito study the impact of MCR-1 products on E. coli-induced activation of inflammatory pathways in activated THP-1 cells, which was used as a model of human macrophages.

Published
2020
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17. Modulation of the immune and inflammatory responses by Plasmodium falciparum schizont extracts: role of myeloid dendritic cells in effector and regulatory functions of CD4+ lymphocytes.

Author

Clemente AM, Fadigati G, Caporale R, Marchese DG, Castronovo G, Sannella AR, Severini C, Verra F, Garaci E, Cozzolino F, and Torcia MG

Subjects
Cell Differentiation immunology, Cytokines metabolism, T-Lymphocytes, Regulatory immunology, T-Lymphocytes, Regulatory metabolism, Dendritic Cells immunology, Inflammation immunology, Myeloid Cells immunology, Plasmodium falciparum immunology, T-Lymphocytes, Regulatory parasitology
Abstract

The optimal immune response to malaria infection comprises rapid induction of inflammatory responses promptly counteracted by regulatory mechanisms to prevent immunopathology. To evaluate the role of dendritic cells (DC) in the balance of parasite-induced inflammatory/anti-inflammatory mechanisms, we studied the activity of monocyte-derived dendritic cells (MDDC), previously exposed to soluble extracts of Plasmodium falciparum-infected red blood cells (PfSE), in the differentiation of CD4 cells isolated from donors never exposed to malaria infection. We show that MDDC exposed to PfSE are extremely efficient to induce a contemporary differentiation of TH1 effector cells and T regulatory (Treg) cells in CD4 T cells even when exposed to low concentrations of parasitic extracts. Treg cells induced by MDDC infected with PfSE (MDDC-PfSE) produce transforming growth factor beta (TGF-β) and interleukin 10 (IL-10) and are endowed with strong suppressive properties. They also show phenotypical and functional peculiarities, such as the contemporary expression of markers of Treg and TH1 differentiation and higher sensitivity to TLR4 ligands both inducing an increasing production of suppressive cytokines. On the whole, our data indicate that MDDC exposed to PfSE orchestrate a well-balanced immune response with timely differentiation of TH1 and Treg cells in CD4 cells from nonimmune donors and suggest that, during the infection, the role of MDCC could be particularly relevant in low-parasitemia conditions.

Published
2013
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