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5. Out of the Clinic, into the Home: The in-Home Use of Phantom Motor Execution Aided by Machine Learning and Augmented Reality for the Treatment of Phantom Limb Pain

Author

Lendaro E, Middleton A, Brown S, and Ortiz-Catalan M

Subjects
phantom limb pain, neuropathic pain, augmented reality, phantom motor execution, ethnography, user interaction design, Medicine (General), R5-920
Abstract

Eva Lendaro, 1 Alexandra Middleton, 2 Shannon Brown, 1 Max Ortiz-Catalan 1 1Biomechatronics and Neurorehabilitation Laboratory, Department of Electrical Engineering, Chalmers University of Technology, Gothenburg, Sweden; 2Department of Anthropology, Princeton University, Princeton, NJ, USACorrespondence: Max Ortiz-CatalanDepartment of Electrical Engineering, Biomechatronics and Neurorehabilitation Laboratory, Chalmers University of Technology, Hörsalsvägen 9, SE - 412 96, Gothenburg, SwedenTel +46 70-423 13 52Email maxo@chalmers.sePurpose: Phantom motor execution (PME) facilitated by augmented/virtual reality (AR/VR) and serious gaming (SG) has been proposed as a treatment for phantom limb pain (PLP). Evidence of the efficacy of this approach was obtained through a clinical trial involving individuals with chronic intractable PLP affecting the upper limb, and further evidence is currently being sought with a multi-sited, international, double blind, randomized, controlled clinical trial in upper and lower limb amputees. All experiments have been conducted in a clinical setting supervised by a therapist. Here, we present a series of case studies (two upper and two lower limb amputees) on the use of PME as a self-treatment. We explore the benefits and the challenges encountered in translation from clinic to home use with a holistic, mixed-methods approach, employing both quantitative and qualitative methods from engineering, medical anthropology, and user interface design.Patients and Methods: All patients were provided with and trained to use a myoelectric pattern recognition and AR/VR device for PME. Patients took these devices home and used them independently over 12 months.Results: We found that patients were capable of conducting PME as a self-treatment and incorporated the device into their daily life routines. Use patterns and adherence to PME practice were not only driven by the presence of PLP but also influenced by patients’ perceived need and social context. The main barriers to therapy adherence were time and availability of single-use electrodes, both of which could be resolved, or attenuated, by informed design considerations.Conclusion: Our findings suggest that adherence to treatment, and thus related outcomes, could be further improved by considering disparate user types and their utilization patterns. Our study highlights the importance of understanding, from multiple disciplinary angles, the tight coupling and interplay between pain, perceived need, and use of medical devices in patient-initiated therapy.Keywords: phantom limb pain, neuropathic pain, augmented reality, phantom motor execution, ethnography, user interaction design

Published
2020

8. The Catalina Real-time Transient Survey

Author

Drake, A. J., Djorgovski, S. G., Mahabal, A., Prieto, J. L., Beshore, E., Graham, M. J., Catalan, M., Larson, S., Christensen, E., Donalek, C., and Williams, R.

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

The Catalina Real-time Transient Survey (CRTS) currently covers 33,000 deg^2 of the sky in search of transient astrophysical events, with time baselines ranging from 10 minutes to ~7 years. Data provided by the Catalina Sky Survey provides an unequaled baseline against which >4,000 unique optical transient events have been discovered and openly published in real-time. Here we highlight some of the discoveries of CRTS., Comment: To appear in proc. IAU Symp. 285, "New Horizons in Time Domain Astronomy", eds. E. Griffin et al., Cambridge Univ. Press (2012), 3 pages

Published
2011
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10. Cyclical period changes in Z Chamaeleontis

Author

Baptista, R., Jablonski, F., Oliveira, E., Vrielmann, S., Woudt, P. A., and Catalan, M. S.

Subjects
Astrophysics
Abstract

We report the identification of cyclical changes in the orbital period of the eclipsing dwarf nova Z Cha. We used times of mid-eclipse collected from the literature and our new eclipse timings to construct an observed-minus-calculated diagram covering 30 years of observations (1972-2002). The data present cyclical variations that can be fitted by a linear plus sinusoidal function with period 28+/-2 yr and amplitude 1.0+/-0.2 minute. The statistical significance of this period by an F-test is larger than 99.9%. The derived fractional period change, Delta P/P= 4.4 x 10^{-7}, is comparable to that of other short-period cataclysmic variables (CVs), but is one order of magnitude smaller than those of the long-period CVs. Separate fits to the first and second half of the data lead to ephemerides with quite different cycle periods and amplitudes, indicating that the variation is not sinusoidal or, most probably, is not strictly periodic. The observed cyclical period change is possibly caused by a solar-type magnetic activity cycle in the secondary star. An incremental variation in the Roche lobe of the secondary star of Delta R_{L2}/R_{L2} = 1.7 x 10^{-4} is required in order to explain both the observed period change and the modulation of the quiescent brightness previously reported by Ak, Ozkan & Mattei., Comment: 5 pages, 1 postscript figure, coded with MNRAS latex style file. To appear in Monthly Notices of the Royal Astronomical Society

Published
2002
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11. Changes in the structure of the accretion disc of EX Draconis through the outburst cycle

Author

Baptista, Raymundo and Catalan, M. S.

Subjects
Astrophysics
Abstract

(Abridged) We report on the analysis of high-speed photometry of the dwarf nova EX Dra through its outburst cycle with eclipse mapping techniques. The eclipse maps show evidence of the formation of a one-armed spiral structure in the disc at the early stages of the outburst and reveal how the disc expands during the rise until it fills most of the primary Roche lobe at maximum light. The eclipse maps also suggest the presence of an inward and an outward-moving heating wave during the rise and an inward-moving cooling wave in the decline. Our results suggest a systematic deceleration of both the heating and the cooling waves as they travel across the disc, in agreement with predictions of the disc instability model. The analysis of the brightness temperature profiles indicates that most of the disc appears to be in steady-state during quiescence and at outburst maximum, but not during the intermediate stages. As a general trend, the mass accretion rate in the outer regions is larger than in the inner disc on the rising branch, while the opposite holds during the decline branch. We estimate a mass accretion rate of Mdot= 10^{-8} Msun/yr at outburst maximum and Mdot= 10^{-9.1} Msun/yr in quiescence. The brightness temperature profile in quiescence also suggests that the viscosity parameter is high at this stage which favours the mass-transfer instability model. The uneclipsed light has a steady component, understood in terms of emission from the red secondary star, and a variable component that is proportional to the out of eclipse flux and corresponds to about 3 per cent of the total brightness of the system. The variable component is interpreted as arising in a disc wind., Comment: To appear in Mon. Not. R. Ast. Soc., 14 pages, 9 figures, coded with MNRAS latex style

Published
2000
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12. A spiral structure in the disk of EX Draconis on the rise to outburst maximum

Author

Baptista, Raymundo and Catalan, M. S.

Subjects
Astrophysics
Abstract

We report on the R-band eclipse mapping analysis of high-speed photometry of the dwarf nova EX Dra on the rise to the maximum of the November 1995 outburst. The eclipse map shows a one-armed spiral structure of ~180 degrees in azimuth, extending in radius from R ~0.2 to 0.43 R_{L1} (where R_{L1} is the distance from the disk center to the inner Lagrangian point), that contributes about 22 per cent of the total flux of the eclipse map. The spiral structure is stationary in a reference frame co-rotating with the binary and is stable for a timescale of at least 5 binary orbits. The comparison of the eclipse maps on the rise and in quiescence suggests that the outbursts of EX Dra may be driven by episodes of enhanced mass-transfer from the secondary star. Possible explanations for the nature of the spiral structure are discussed., Comment: To appear in the Astrophysical Journal Letters; 8 pages, 2 figures; coded with AAS latex style

Published
2000
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13. Eclipse studies of the dwarf-nova Ex Draconis

Author

Baptista, R., Catalan, M. S., and Costa, L.

Subjects
Astrophysics
Abstract

We report on high speed photometry of EX Dra in quiescence and in outburst. The analysis of the lightcurves indicates that the outbursts do not start in the outer disc regions. The disc expands during rise to maximum and shrinks during decline and along the quiescent period. At the end of two outbursts the system was seen to go through a phase of lower brightness, characterized by an out-of-eclipse level ~15 per cent lower than the typical quiescent level and by the fairly symmetric eclipse of a compact source at disc centre with little evidence of a bright spot at disc rim. New eclipse timings were measured and a revised ephemeris was derived. The residuals with respect to the linear ephemeris are well described by a sinusoid of amplitude 1.2 minutes and period \~4 years and are possibly related to a solar-like magnetic activity cycle in the secondary star. Eclipse phases of the compact central source and of the bright spot were used to derive the geometry of the binary. By constraining the gas stream trajectory to pass through the observed position of the bright spot we find q=0.72+/-0.06 and i= 85 +3/-2 degrees. The binary parameters were estimated by combining the measured mass ratio with the assumption that the secondary star obeys an empirical main sequence mass-radius relation. We find M_1= 0.75+/-0.15 M_sun and M_2= 0.54+/-0.10 M_sun. The white dwarf at disc centre is surrounded by an extended and variable atmosphere or boundary layer of at least 3 times its radius and a temperature of T ~28000 K. The fluxes at mid-eclipse yield an upper limit to the contribution of the secondary star and lead to a lower limit photometric parallax distance of D= 290+/-80 pc. The fluxes of the secondary star are well matched by those of a M0+/-2 main sequence star., Comment: submitted to MNRAS, 12 pages, 9 figures; coded with MNRAS latex style

Published
2000
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14. The 'Outside-In' Outburst of HT Cassiopeiae

Author

Ioannou, Zach, Naylor, T., Welsh, W. F., Catalan, M. S., Worraker, W. J., and James, N. D.

Subjects
Astrophysics
Abstract

We present results from photometric observations of the dwarf nova system HT Cas during the eruption of November 1995. The data include the first two--colour observations of an eclipse on the rise to outburst. They show that during the rise to outburst the disc deviates significantly from steady state models, but the inclusion of an inner-disc truncation radius of about 4 $R_{wd}$ and a ``flared'' disc of semi-opening angle of $10^{\circ}$ produces acceptable fits. The disc is found to have expanded at the start of the outburst to about $0.41R_{L1}$, as compared to quiescent measurements. The accretion disc then gradually decreases in radius reaching $<0.32R_{L1}$ during the last stages of the eruption. Quiescent eclipses were also observed prior to and after the eruption and a revised ephemeris is calculated., Comment: 9 pages, 11 figures, to appear in MNRAS

Published
1999
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15. Changes in the structure of the accretion disc of HS1804+67 through the outburst cycle

Author

Baptista, Raymundo and Catalan, M. S.

Subjects
Astrophysics
Abstract

We report on the analysis of high-speed photometry of the dwarf-nova HS1804+67 through its outburst cycle with eclipse mapping techniques. Eclipse maps show evidences of the formation of a spiral structure in the disc at the early stages of the outburst and reveal how the disc expands during the rise until its fills most of the primary Roche lobe at maximum light. During the decline phase, the disc becomes progressively fainter as the cooling front moves inwards from the outer regions, until only a small bright region around the white dwarf is left at minimum light. The variable part of the uneclipsed light is possibly due to emission in a wind emanating from the inner parts of the disc. The emission from this region is sensitive to the mass accretion rate., Comment: 4 pages, 3 postscript figures, latex file, to appear in "Cataclysmic Variables: a 60th Birthday Symposium in Honour of Brian Warner", eds. P. Charles et al, New Astronomy Reviews

Published
1999

16. HST and ground-based eclipse observations of V2051 Ophiuchi: Binary parameters

Author

Baptista, Raymundo, Catalan, M. S., Horne, Keith, and Zilli, D.

Subjects
Astrophysics
Abstract

We report on high-speed eclipse photometry of the dwarf nova V2051 Oph while it was in a low brightness state, at B ~ 16.2 mag. In comparison to the average IUE spectra, the ultraviolet continuum and emission lines appear reduced by factors of, respectively, ~4 and ~5. Flickering activity is mostly suppressed and the lightcurve shows the eclipse of a compact white dwarf at disc centre which contributes ~60 per cent of the total light at 3900--4300 A. We use measurements of contact phases in the eclipse lightcurve to derive the binary geometry and to estimate masses and relevant dimensions. We find a mass ratio of q= 0.19+/-0.03 and an inclination of i= 83+/-2 degrees. The masses of the component stars are M_1 = 0.78+/-0.06 M_dot and M_2 = 0.15+/-0.03 M_dot. Our photometric model predicts K_1 = 83+/-12 km/s and K_2= 435+/-11 km/s. The predicted value of K_1 is in accordance with the velocity amplitude obtained from the emission lines after a correction for asymmetric line emission in the disc is made (Watts et al. 1986). The secondary of V2051 Oph is significantly more massive than the secondaries of the other ultra-short period dwarf novae. V2051 Oph is probably a relatively young system, whose secondary star had not enough time to evolve out of thermal equilibrium., Comment: 16 pages, 7 postscript figures, coded using MNRAS latex style. To appear in Monthly Notices of the Royal Astronomical Society. Revised version with changes in section 4.3. For related papers and files see ftp://fsc01.fsc.ufsc.br/pub/bap and http://www.fsc.ufsc.br/~astro

Published
1998
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17. Effects of intubation timing in patients with COVID-19 throughout the four waves of the pandemic: a matched analysis

Author

Universitat Rovira i Virgili, Riera, J; Barbeta, E; Tormos, A; Mellado-Artigas, R; Ceccato, A; Motos, A; Fernandez-Barat, L; Ferrer, R; Garcia-Gasulla, D; Penuelas, O; Lorente, JA; Menendez, R; Roca, O; Palomeque, A; Ferrando, C; Sole-Violan, J; Novo, M; Boado, MV; Tamayo, L; Estella, A; Galban, C; Trenado, J; Huerta, A; Loza, A; Aguilera, L; Garmendia, JLG; Barbera, C; Gumucio, V; Socias, L; Franco, N; Valdivia, LJ; Vidal, P; Sagredo, V; Ruiz-Garcia, AL; Varela, IM; Lopez, J; Pozo, JC; Nieto, M; Gomez, JM; Blandino, A; Valledor, M; Bustamante-Munguira, E; Sanchez-Miralles, A; Penasco, Y; Barberan, J; Ubeda, A; Amaya-Villar, R; Martin, MC; Jorge, R; Caballero, J; Marin, J; Anon, JM; Sipmann, FS; Albaiceta, GM; Castellanos-Ortega, A; Adell-Serrano, B; Catalan, M; Gandara, AMD; Ricart, P; Carbajales, C; Rodriguez, A; Diaz, E; Torre, MCD; Gallego, E; Canton-Bulnes, L; Carbonell, N; Gonzalez, J; de Gonzalo-Calvo, D; Barbe, F; Torres, A, Universitat Rovira i Virgili, and Riera, J; Barbeta, E; Tormos, A; Mellado-Artigas, R; Ceccato, A; Motos, A; Fernandez-Barat, L; Ferrer, R; Garcia-Gasulla, D; Penuelas, O; Lorente, JA; Menendez, R; Roca, O; Palomeque, A; Ferrando, C; Sole-Violan, J; Novo, M; Boado, MV; Tamayo, L; Estella, A; Galban, C; Trenado, J; Huerta, A; Loza, A; Aguilera, L; Garmendia, JLG; Barbera, C; Gumucio, V; Socias, L; Franco, N; Valdivia, LJ; Vidal, P; Sagredo, V; Ruiz-Garcia, AL; Varela, IM; Lopez, J; Pozo, JC; Nieto, M; Gomez, JM; Blandino, A; Valledor, M; Bustamante-Munguira, E; Sanchez-Miralles, A; Penasco, Y; Barberan, J; Ubeda, A; Amaya-Villar, R; Martin, MC; Jorge, R; Caballero, J; Marin, J; Anon, JM; Sipmann, FS; Albaiceta, GM; Castellanos-Ortega, A; Adell-Serrano, B; Catalan, M; Gandara, AMD; Ricart, P; Carbajales, C; Rodriguez, A; Diaz, E; Torre, MCD; Gallego, E; Canton-Bulnes, L; Carbonell, N; Gonzalez, J; de Gonzalo-Calvo, D; Barbe, F; Torres, A

Abstract

Background The primary aim of our study was to investigate the association between intubation timing and hospital mortality in critically ill patients with coronavirus disease 2019 (COVID-19)-associated respiratory failure. We also analysed both the impact of such timing throughout the first four pandemic waves and the influence of prior noninvasive respiratory support on outcomes.Methods This is a secondary analysis of a multicentre, observational and prospective cohort study that included all consecutive patients undergoing invasive mechanical ventilation due to COVID-19 from across 58 Spanish intensive care units (ICUs) participating in the CIBERESUCICOVID project. The study period was between 29 February 2020 and 31 August 2021. Early intubation was defined as that occurring within the first 24 h of ICU admission. Propensity score matching was used to achieve a balance across baseline variables between the early intubation cohort and those patients who were intubated after the first 24 h of ICU admission. Differences in outcomes between early and delayed intubation were also assessed. We performed sensitivity analyses to consider a different time-point (48 h from ICU admission) for early and delayed intubation.Results Of the 2725 patients who received invasive mechanical ventilation, a total of 614 matched patients were included in the analysis (307 for each group). In the unmatched population, there were no differences in mortality between the early and delayed groups. After propensity score matching, patients with delayed intubation presented higher hospital mortality (27.3% versus 37.1%; p=0.01), ICU mortality (25.7% versus 36.1%; p=0.007) and 90-day mortality (30.9% versus 40.2%; p=0.02) compared with the early intubation group. Very similar findings were observ

Published
2023

22. Latest version of the World Digital Magnetic Anomaly Map (WDMAM v.2.1) released

Author

Dyment, J., Choi, Y., Lesur, V., Garcia-Reyes, A., Catalan, M., Ishihara, T., Litvinova, T., and Hamoudi, M.

Abstract

The last version of the World Digital Magnetic Anomaly Map (WDMAM v. 2.0) was released in 2015 (Dyment et al., EPSL, 2015; Lesur et al., EPS, 2016) with the mandate to update it using the same methodology when new data become available. The new version 2.1, compiled at 5km interval, at 5km altitude above the continents and at sea-level over the oceans, includes new datasets: (1) the complete digital aeromagnetic map of Brasil made available by ANP; (2) an improved version of the aeromagnetic map of Russia prepared by V-SEGEI; (3) the second version of the Antarctic Digital Magnetic Anomaly maP (ADMAP; Golynsky et al., GRL, 2018) which results from a remarkable international effort during and after the Second International Polar Year; (4) a new map of the Caribbean Plate and Gulf of Mexico (Garcia and Dyment, EPSL, 2021, 2022); (5) the updated Magnetic Anomaly Map of Eastern Asia prepared by the CCOP (MAMEA; Ishihara and Uchida, 2021); and (6) a new marine magnetic anomaly data compilation prepared by T. Ishihara and coworkers. The remaining data gaps are filled with a satellite anomaly model (Thebault et al., GRL, 2021). Long wavelengths of degree and order lower than 120 are filtered and replaced by those computed between order and degree 16 and 120 using the same satellite magnetic anomaly model from CHAMP and Swarm data. The new map will be presented and its significant improvements over the previous version discussed., The 28th IUGG General Assembly (IUGG2023) (Berlin 2023)

Published
2023
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26. ESICM LIVES 2016: part three: Milan, Italy. 1–5 October 2016

Author

Velasquez, T., Mackey, G., Lusk, J., Kyle, U. G., Fontenot, T., Marshall, P., Shekerdemian, L. S., Coss-Bu, J. A., Nishigaki, A., Yatabe, T., Tamura, T., Yamashita, K., Yokoyama, M., Ruiz-Rodriguez, J. C., Encina, B., Belmonte, R., Troncoso, I., Tormos, P., Riveiro, M., Baena, J., Sanchez, A., Bañeras, J., Cordón, J., Duran, N., Ruiz, A., Caballero, J., Nuvials, X., Riera, J., Serra, J., Rutten, A. M. F., van Ieperen, S. N. M., Der Kinderen, E. P. H. M., Van Logten, T., Kovacikova, L., Skrak, P., Zahorec, M., Kyle, U. G., Akcan-Arikan, A., Silva, J. C., Mackey, G., Lusk, J., Goldsworthy, M., Shekerdemian, L. S., Coss-Bu, J. A., Wood, D., Harrison, D., Parslow, R., Davis, P., Pappachan, J., Goodwin, S., Ramnarayan, P., Chernyshuk, S., Yemets, H., Zhovnir, V., Pulitano’, S. M., De Rosa, S., Mancino, A., Villa, G., Tosi, F., Franchi, P., Conti, G., Patel, B., Khine, H., Shah, A., Sung, D., Singer, L., Haghbin, S., Inaloo, S., Serati, Z., Idei, M., Nomura, T., Yamamoto, N., Sakai, Y., Yoshida, T., Matsuda, Y., Yamaguchi, Y., Takaki, S., Yamaguchi, O., Goto, T., Longani, N., Medar, S., Abdel-Aal, I. R., El Adawy, A. S., Mohammed, H. M. E. H., Mohamed, A. N., Parry, S. M., Knight, L. D., Denehy, L., De Morton, N., Baldwin, C. E., Sani, D., Kayambu, G., da Silva, V. Z. M., Phongpagdi, P., Puthucheary, Z. A., Granger, C. L., Rydingsward, J. E., Horkan, C. M., Christopher, K. B., McWilliams, D., Jones, C., Reeves, E., Atkins, G., Snelson, C., Aitken, L. M., Rattray, J., Kenardy, J., Hull, A. M., Ullman, A., Le Brocque, R., Mitchell, M., Davis, C., Macfarlane, B., Azevedo, J. C., Rocha, L. L., De Freitas, F. F. M., Cavalheiro, A. M., Lucinio, N. M., Lobato, M. S., Ebeling, G., Kraegpoeth, A., Laerkner, E., De Brito-Ashurst, I., White, C., Gregory, S., Forni, L. G., Flowers, E., Curtis, A., Wood, C. A., Siu, K., Venkatesan, K., Muhammad, J. B. H., Ng, L., Seet, E., Baptista, N., Escoval, A., Tomas, E., Agrawal, R., Mathew, R., Varma, A., Dima, E., Charitidou, E., Perivolioti, E., Pratikaki, M., Vrettou, C., Giannopoulos, A., Zakynthinos, S., Routsi, C., Atchade, E., Houzé, S., Jean-Baptiste, S., Thabut, G., Genève, C., Tanaka, S., Lortat-Jacob, B., Augustin, P., Desmard, M., Montravers, P., de Molina, F. J. González, Barbadillo, S., Alejandro, R., Álvarez-Lerma, F., Vallés, J., Catalán, R. M., Palencia, E., Jareño, A., Granada, R. M., Ignacio, M. L., Cui, N., Liu, D., Wang, H., Su, L., Qiu, H., Li, R., Jaffal, K., Rouzé, A., Poissy, J., Sendid, B., Nseir, S., Paramythiotou, E., Rizos, M., Frantzeskaki, F., Antoniadou, A., Vourli, S., Zerva, L., Armaganidis, A., Riera, J., Gottlieb, J., Greer, M., Wiesner, O., Martínez, M., Acuña, M., Rello, J., Welte, T., Atchade, E., Mignot, T., Houzé, S., Jean-Baptiste, S., Thabut, G., Lortat-Jacob, B., Tanaka, S., Augustin, P., Desmard, M., Montravers, P., Soussi, S., Dudoignon, E., Ferry, A., Chaussard, M., Benyamina, M., Alanio, A., Touratier, S., Chaouat, M., Lafaurie, M., Mimoun, M., Mebazaa, A., Legrand, M., Sheils, M. A., Patel, C., Mohankumar, L., Akhtar, N., Noriega, S. K. Pacheco, Aldana, N. Navarrete, León, J. L. Ávila, Baquero, J. Durand, Bernal, F. Fernández, Ahmadnia, E., Hadley, J. S., Millar, M., Hall, D., Hewitt, H., Yasuda, H., Sanui, M., Komuro, T., Kawano, S., Andoh, K., Yamamoto, H., Noda, E., Hatakeyama, J., Saitou, N., Okamoto, H., Kobayashi, A., Takei, T., Matsukubo, S., Rotzel, H. B., Lázaro, A. Serrano, Prada, D. Aguillón, Gimillo, M. Rodriguez, Barinas, O. Diaz, Cortes, M. L. Blasco, Franco, J. Ferreres, Roca, J. M. Segura, Carratalá, A., Gonçalves, B., Turon, R., Mendes, A., Miranda, F., Mata, P. J., Cavalcanti, D., Melo, N., Lacerda, P., Kurtz, P., Righy, C., Rosario, L. E. de la Cruz, Lesmes, S. P. Gómez, Romero, J. C. García, Herrera, A. N. García, Pertuz, E. D. Díaz, Sánchez, M. J. Gómez, Sanz, E. Regidor, Hualde, J. Barado, Hernández, A. Ansotegui, Irazabal, J. M. Guergué, Spatenkova, V., Bradac, O., Suchomel, P., Urli, T., Lazzeri, E. Heusch, Aspide, R., Zanello, M., Perez-Borrero, L., Garcia-Alvarez, J. M., Arias-Verdu, M. D., Aguilar-Alonso, E., Rivera-Fernandez, R., Mora-Ordoñez, J., De La Fuente-Martos, C., Castillo-Lorente, E., Guerrero-Lopez, F., Lesmes, S. P. Gómez, Rosario, L. E. De la Cruz, Pertuz, E. D. Díaz, Hernández, A. Ansotegui, Romero, J. C. García, Sánchez, M. J. Gómez, Herrera, A. N. García, Ramírez, J. Roldán, Sanz, E. Regidor, Hualde, J. Barado, León, J. P. Tirapu, Navarro-Guillamón, L., Cordovilla-Guardia, S., Iglesias-Santiago, A., Guerrero-López, F., Fernández-Mondéjar, E., Vidal, A., Perez, M., Juez, A., Arias, N., Colino, L., Perez, J. L., Pérez, H., Calpe, P., Alcala, M. A., Robaglia, D., Perez, C., Lan, S. K., Cunha, M. M., Moreira, T., Santos, F., Lafuente, E., Fernandes, M. J., Silva, J. G., Rosario, L. E. de la Cruz, Lesmes, S. P. Gómez, Herrera, A. N. García, Romero, J. C. García, Pertuz, E. D. Díaz, Sánchez, M. J. Gómez, Sanz, E. Regidor, Echeverría, J. G. Armando, Hernández, A. Ansotegui, Hualde, J. Barado, Podlepich, V., Sokolova, E., Alexandrova, E., Lapteva, K., Kurtz, P., Shuinotsuka, C., Rabello, L., Vianna, G., Reis, A., Cairus, C., Salluh, J., Bozza, F., Torres, J. C. Barrios, Araujo, N. J. Fernández, García-Olivares, P., Keough, E., Dalorzo, M., Tang, L. K., De Sousa, I., Díaz, M., Marcos-Zambrano, L. J., Guerrero, J. E., Gomez, S. E. Zamora, Lopez, G. D. Hernandez, Cuellar, A. I. Vazquez, Nieto, O. R. Perez, Gonzalez, J. A. Castanon, Bhasin, D., Rai, S., Singh, H., Gupta, O., Bhattal, M. K., Sampley, S., Sekhri, K., Nandha, R., Aliaga, F. A., Olivares, F., Appiani, F., Farias, P., Alberto, F., Hernández, A., Pons, S., Sonneville, R., Bouadma, L., Neuville, M., Mariotte, E., Radjou, A., Lebut, J., Chemam, S., Voiriot, G., Dilly, M. P., Mourvillier, B., Dorent, R., Nataf, P., Wolff, M., Timsit, J. F., Ediboglu, O., Ataman, S., Ozkarakas, H., Kirakli, C., Vakalos, A., Avramidis, V., Obukhova, O., Kurmukov, I. A., Kashiya, S., Golovnya, E., Baikova, V. 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Hípola, Vázquez, C. F. Lübbe, Penichet, S. M. Marrero, Campelo, F. Artiles, López, M. A. De La Cal, Santana, P. Saavedra, Santana, S. Ruíz, Repessé, X., Artiguenave, M., Paktoris-Papine, S., Espinasse, F., Dinh, A., El Sayed, F., Charron, C., Géri, G., Vieillard-Baron, A., Marmanidou, K., Oikonomou, M., Nouris, C., Dimitroulakis, K., Soilemezi, E., Matamis, D., Ferré, A., Guillot, M., Teboul, J. L., Lichtenstein, D., Mézière, G., Richard, C., Monnet, X., Pham, T., Beduneau, G., Schortgen, F., Piquilloud, L., Zogheib, E., Jonas, M., Grelon, F., Runge, I., Terzi, N., Grangé, S., Barberet, G., Guitard, P. G., Frat, J. P., Constan, A., Chrétien, J. M., Mancebo, J., Mercat, A., Richard, J. C. M., Brochard, L., Prīdāne, S., Sabeļņikovs, O., Mojoli, F., Orlando, A., Bianchi, I., Torriglia, F., Bianzina, S., Pozzi, M., Iotti, G. A., Braschi, A., Beduneau, G., Pham, T., Schortgen, F., Piquilloud, L., Zogheib, E., Jonas, M., Grelon, F., Runge, I., Terzi, N., Grangé, S., Barberet, G., Guitard, P. G., Frat, J. P., Constan, A., Chrétien, J. M., Mancebo, J., Mercat, A., Richard, J. C. M., Brochard, L., Kondili, E., Psarologakis, C., Kokkini, S., Amargianitakis, V., Babalis, D., Chytas, A., Chouvarda, I., Vaporidi, K., Georgopoulos, D., Trapp, O., Kalenka, A., Mojoli, F., Orlando, A., Bianchi, I., Torriglia, F., Bianzina, S., Pozzi, M., Iotti, G. A., Braschi, A., Lozano, J. A. Benítez, Sánchez, P. Carmona, Francioni, J. E. Barrueco, Ferrón, F. Ruiz, Simón, J. M. Serrano, Spadaro, S., Karbing, D. S., Gioia, A., Moro, F., Corte, F. Dalla, Mauri, T., Volta, C. A., Rees, S. E., Petrova, M. V., Mohan, R., Butrov, A. V., Beeharry, S. D., Vatsik, M. V., Sakieva, F. I., Gobert, F., Yonis, H., Tapponnier, R., Fernandez, R., Labaune, M. A., Burle, J. F., Barbier, J., Vincent, B., Cleyet, M., Richard, J. C., Guérin, C., Shinotsuka, C. Righy, Creteur, J., Taccone, F. S., Törnblom, S., Nisula, S., Vaara, S., Poukkanen, M., Andersson, S., Pettilä, V., Pesonen, E., Xie, Z., Liao, X., Kang, Y., Zhang, J., Kubota, K., Egi, M., Mizobuchi, S., Hegazy, S., El-Keraie, A., El Sayed, E., El Hamid, M. Abd, Rodrigues, N. J., Pereira, M., Godinho, I., Gameiro, J., Neves, M., Gouveia, J., e Silva, Z. Costa, Lopes, J. A., Mckinlay, J., Kostalas, M., Kooner, G., Dudas, G., Horton, A., Kerr, C., Karanjia, N., Creagh-Brown, B., Forni, L., Yamazaki, A., Ganuza, M. Sanz, Molina, J. A. Martinez, Martinez, F. Hidalgo, Freile, M. T. Chiquito, Fernandez, N. Garcia, Travieso, P. Medrano, Bandert, A., Frithiof, R., Lipcsey, M., Smekal, D., Schlaepfer, P., Durovray, J. D., Plouhinec, V., Chiappa, C., Bellomo, R., Schneider, A. G., Mitchell, S., Durrant, J., Street, H., Dunthorne, E., Shears, J., Caballero, C. Hernandez, Hutchison, R., Schwarze, S., Ghabina, S., Thompson, E., Prowle, J. R., Kirwan, C. J., Gonzalez, C. A., Pinto, J. L., Orozco, V., Patiño, J. A., Garcia, P. K., Contreras, K. M., Rodriguez, P., Echeverri, J. E., GETGAG Working Group, JSEPTIC (Japanese Society of Education for Physicians and Trainees in Intensive Care) Clinical Trial Group, CAPCRI Study, for the ReVA Research Network and the PROVE Network Investigators, from the FROG ICU Investigators, The WIND study group, Plug Working Group, GETGAG/SEMICYUC, AKI Research Group, St George’s University of London, IPREA Study Group, FINNRESUSCI Study Group, PICS- HCPA: Programa Intrahospitalar de Combate à Sepse do Hospital de Clínicas de Porto Alegre, ENVIN-HELICS Study Group, ARIAM registry of adult cardiac surgery, The Rapid Diagnosis of Infections in the Critically Ill Team, Tokyo Womens Medical University, PLUG working group, PLUG Working Group, On behalf of Okayama Research Investigation Organizing Network (ORION)investigators, PS-ICU Group, Japan Septic Disseminated Intravascular Coagulation (JSEPTIC DIC) study group, Student Research Committee - Shiraz University of Medical Sciences, ARIAM-ANDALUCIA, The WIND study group, PLUG Working Group, The WIND study group, PLUG Working Group, and Plug working group

Published
2016
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28. Proof-of-Concept of Direct-to-Satellite IoT for Earth Observation Applications: Soil Moisture Experiment

Author

Ruiz-de-Azua, J.A., primary, Pages, J., additional, Labella, C., additional, Delgado, P., additional, Catalan, M., additional, Medina, M., additional, Paradells, J., additional, Guixe, P., additional, Figuerola, S., additional, Jara, J.A., additional, Llados, A., additional, Talaya, J., additional, Corbera, J., additional, Monton, M., additional, Colome, J., additional, de Quadras, M., additional, Llorens, I., additional, and Guadalupi, M., additional

Published
2022
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31. Correction: Olfactory swab sampling optimization for α-synuclein aggregate detection in patients with Parkinson’s disease (Translational Neurodegeneration, (2022), 11, 1, (37), 10.1186/s40035-022-00311-3)

Author

Bongianni, M., Catalan, M., Perra, D., Fontana, E., Janes, F., Bertolotti, C., Sacchetto, L., Capaldi, S., Tagliapietra, M., Polverino, P., Tommasini, V., Bellavita, G., Kachoie, E. A., Baruca, R., Bernardini, A., Valente, M., Fiorini, M., Bronzato, E., Tamburin, S., Bertolasi, L., Brozzetti, L., Cecchini, M. P., Gigli, G., Monaco, S., Manganotti, P., and Zanusso, G.

Published
2022

32. A prospective comparison of galactomannan in bronchoalveolar lavage fluid for the diagnosis of pulmonary invasive aspergillosis in medical patients under intensive care: comparison with the diagnostic performance of galactomannan and of (1→ 3) – β – d-glucan chromogenic assay in serum samples

Author

Acosta, J., Catalan, M., Palacio-Peréz-Medel, A. del, Lora, D., Montejo, J.-C., Cuetara, M.-S., Moragues, M.-D., Ponton, J., and del Palacio, A.

Published
2011
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33. Influenza epidemiology and influenza vaccine effectiveness during the 2016–2017 season in the Global Influenza Hospital Surveillance Network (GIHSN)

Author

Eropkin, M., Fadeev, A., Andrew, M., Ambrose, A., Mukasheva, E., Merkulova, L., Kruzhkova, I., Krasnoslobotsev, K., Kolobukhina, L., Kisteneva, L., Garina, E., Schwarz-Chavarri, G., Llorente-Nieto, P., Tortajada-Girbes, M., Fernandez-Dopazo, J., Generalova, L., Go, A., Golovacheva, E., Gonchar, V., Komissarov, A., Konovalova, N., Kuvarzina, S., Levanyuk, T., Lobova, T., Osidak, L., Roldan-Aguado, M., Mollar Maseres, J., Carballido-Fernandez, M., Adriana-Magos, E., Lopez-Labrador, X., Menif, K., Ozkaya-Parlakay, A., Tezer, H., Gulhan, B., Pisareva, M., Boukthir, A., Chlif, S., Rozhkova, E., Dellagi, M. K., Gharbi, A., Louzir, H., Yazidi, R., Zid, W., Laguna, A., Perez-Bao, J., Reyes, N., Coulibaly, D., Sanchez-Catalan, M. J., Mira-Iglesias, A., Martin-Navarro, M., Guglieri-Lopez, B., Garcia Esteban, S., Escribano-Lopez, B., Diez-Domingo, Javier, Puig-Barbera, Joan, Burtseva, Elena, Ben-Salah, Afif, Kuatbayeva, Ainagul, Sintsova, K., Sirotkina, Z., Smorodintseva, E., Koubaa, M., Zhang, Tao, Kyncl, Jan, Koul, Parvaiz, ÜNAL, SERHAT, Draganescu, Anca, Nunes, Marta C., Sominina, Anna, McNeil, Shelly, Ben Jeema, M., Trushakova, Svetlana, Baselga-Moreno, Victor, Ben Khelil, J., Amine, S., Gaukhar, N., Pitigoi, D., MacKinnon-Cameron, D., Nichols-Evans, M., Ye, P., Afanasieva, O., Afanasieva, A., Demina, S., Dondurei, E., Sukhovetskaya, V., Tamila, M., Voloshuk, L., Yanina, M., Zarishnyuk, P., Madhi, S. A., Arama, V., Florea, D., Luminos, M., Otelea, D., Sandulescu, O., Vlaicu, O., ElSherif, M., Aykac, K., Bosi, T. Bagci, Bilgin, E., Durusu, M., Kara, A., Ozisik, L., Basaranoglu, S. Tanir, Demirdag, TUĞBA, Tunccan, ÖZLEM, Ozgen, O., Pan, J., Zheng, J., Yan, Y., Zhao, G., Zhang, F., Shan, W., Chen, K., Standerova, I., Rudova, T., Rohacova, H., Herrmanova, K., Dvorska, D., Sebestova, H., Prochazkova, J., Mandakova, Z., Kralova, R., Jirincova, H., Havlickova, M., Bali, N., Yusuf, R., Soumya, Soumya, Mir, H., Khan, M., Ali, S., Hernandez, A., Moreno-Espinosa, S., Gamino-Arroyo, A. E., de la Rosa-Zamboni, D., Vidal-Vazquez, R. P., Ramirez-Hinojosa, J. P., Jimenez-Escobar, I., Dolores Dominguez-Viveros, W., de Colsa Ranero, A., Ruiz-Palacios, G. M., Guerrero Almeida, M. L., Galindo Fraga, A., Ciblak, M. Akcay, Tulek, N., Ozsoy, M., and Stolyarov, K.

Subjects
Adult, Male, medicine.medical_specialty, Adolescent, Influenza vaccine, Epidemiology, 030209 endocrinology & metabolism, Logistic regression, Global Health, 03 medical and health sciences, 0302 clinical medicine, Influenza A Virus, H1N1 Subtype, Pregnancy, Internal medicine, Influenza, Human, medicine, Humans, 030212 general & internal medicine, Risk factor, Child, Aged, Aged, 80 and over, Vaccine effectiveness, Surveillance, business.industry, Influenza A Virus, H3N2 Subtype, lcsh:Public aspects of medicine, Vaccination, Public Health, Environmental and Occupational Health, lcsh:RA1-1270, Odds ratio, Middle Aged, medicine.disease, Hospitalization, Influenza Vaccines, Child, Preschool, Female, Seasons, Biostatistics, business, Influenza virus, Sentinel Surveillance, Research Article
Abstract

Background The Global Influenza Hospital Surveillance Network (GIHSN) aims to determine the burden of severe influenza disease and Influenza Vaccine Effectiveness (IVE). This is a prospective, active surveillance and hospital-based epidemiological study to collect epidemiological data in the GIHSN. In the 2016–2017 influenza season, 15 sites in 14 countries participated in the GIHSN, although the analyses could not be performed in 2 sites. A common core protocol was used in order to make results comparable. Here we present the results of the GIHSN 2016–2017 influenza season. Methods A RT-PCR test was performed to all patients that accomplished the requirements detailed on a common core protocol. Patients admitted were included in the study after signing the informed consent, if they were residents, not institutionalised, not discharged in the previous 30 days from other hospitalisation with symptoms onset within the 7 days prior to admission. Patients 5 years old or more must also complied the Influenza-Like Illness definition. A test negative-design was implemented to perform IVE analysis. IVE was estimated using a logistic regression model, with the formula IVE = (1-aOR) × 100, where aOR is the adjusted Odds Ratio comparing cases and controls. Results Among 21,967 screened patients, 10,140 (46.16%) were included, as they accomplished the inclusion criteria, and tested, and therefore 11,827 (53.84%) patients were excluded. Around 60% of all patients included with laboratory results were recruited at 3 sites. The predominant strain was A(H3N2), detected in 63.6% of the cases (1840 patients), followed by B/Victoria, in 21.3% of the cases (618 patients). There were 2895 influenza positive patients (28.6% of the included patients). A(H1N1)pdm09 strain was mainly found in Mexico. IVE could only be performed in 6 sites separately. Overall IVE was 27.24 (95% CI 15.62–37.27. Vaccination seemed to confer better protection against influenza B and in people 2–4 years, or 85 years old or older. The aOR for hospitalized and testing positive for influenza was 3.02 (95% CI 1.59–5.76) comparing pregnant with non-pregnant women. Conclusions Vaccination prevented around 1 in 4 hospitalisations with influenza. Sparse numbers didn’t allow estimating IVE in all sites separately. Pregnancy was found a risk factor for influenza, having 3 times more risk of being admitted with influenza for pregnant women. Electronic supplementary material The online version of this article (10.1186/s12889-019-6713-5) contains supplementary material, which is available to authorized users.

Published
2019

37. Soluble fms-like tyrosine kinase to placental growth factor ratio in different stages of early-onset fetal growth restriction and small for gestational age

Author

Garcia-Manau, P, Mendoza, M, Bonacina, E, Garrido-Gimenez, C, Fernandez-Oliva, A, Zanini, J, Catalan, M, Tur, H, Serrano, B, and Carreras, E

Subjects
fetal growth restriction, small for gestational age, adverse pregnancy outcomes, placental growth factor, angiogenic factors, soluble fms-like tyrosine kinase 1
Abstract

Introduction Increased soluble fms-like tyrosine kinase to placental growth factor ratio (sFlt-1/PlGF) has been demonstrated in early-onset fetal growth restriction (FGR) and small for gestational age (SGA). sFlt-1/PlGF cut-offs have been described to assess preeclampsia severity; however, sFlt-1/PlGF values present in early-onset SGA and different FGR severity stages remain unknown. Hence, the objective of this study was to describe and compare the sFlt-1/PlGF values and pregnancy outcomes among early-onset SGA/FGR stages. Material and methods This is a prospective case-control study conducted at Vall d'Hebron University Hospital. Singleton pregnancies with estimated fetal weight .05) and pregnancy outcomes. However, all FGR stages had significantly poorer outcomes and greater sFlt-1/PlGF values than those of SGA and controls. Furthermore, median values differed significantly among all FGR severity stages (9.76 for stage I; 284.3 for stage II, and 625.02 for stage III,P < .05) increasing with FGR severity as well as the frequency of adverse pregnancy outcomes. Additionally, a significant correlation was found between greater sFlt-1/PlGF ratio values and gestational age at delivery, time from diagnosis to delivery, birthweightz-scores, and time in neonatal intensive care unit (r = -.637,r = -.576,r = -.161, andr = .311, respectively). Conclusions Values of sFlt-1/PlGF at diagnosis permit early-onset FGR/SGA severity classification with good correlation with Doppler ultrasound findings and the occurrence of adverse outcomes. Thus, sFlt-1/PlGF could aid in early-onset FGR/SGA severity classification and clinical management when Doppler assessment is not feasible.

Published
2021

38. Predictors of clinically significant quality of life impairment in Parkinson's disease

Author

Garcia D, Fonticoba T, Cores C, Munoz G, Gonzalez J, Miro C, Suarez E, Jesus S, Aguilar M, Pastor P, Planellas L, Cosgaya M, Caldentey J, Caballol N, Legarda I, Vara J, Cabo I, Manzanares L, Aramburu I, Rivera M, Catalan M, Nogueira V, Puente V, de Arcos M, Borrue C, Vila B, Sauco M, Vela L, Escalante S, Cubo E, Padilla F, Castrillo J, Alonso P, Losada M, Ariztegui N, Gaston I, Clavero P, Kulisevsky J, Estrada M, Seijo M, Martinez J, Valero C, Kurtis M, de Fabregues O, Ardura J, Ordas C, Diaz L, McAfee D, Martinez-Martin P, Mir P, and COPPADIS Study Grp

Abstract

Quality of life (QOL) plays an important role in independent living in Parkinson's disease (PD) patients, being crucial to know what factors impact QoL throughout the course of the disease. Here we identified predictors of QoL impairment in PD patients from a Spanish cohort. PD patients recruited from 35 centers of Spain from the COPPADIS cohort from January 2016, to November 2017, were followed up during 2 years. Health-related QoL (HRQoL) and global QoL (GQoL) were assessed with the 39-item Parkinson's disease Questionnaire (PDQ-39) and the EUROHIS-QOL 8-item index (EUROHIS-QOL8), respectively, at baseline (V0) and at 24 months +/- 1 month (V2). Clinically significant QoL impairment was defined as presenting an increase (PDQ-39SI) or decrement (EUROHIS-QOL8) at V2 >= 10% of the score at baseline (V0). A comparison with a control group was conducted for GQoL. GQoL did not change significantly in PD patients (N = 507; p = 0.686) or in the control group (N = 119; p = 0.192). The mean PDQ-39SI was significantly increased in PD patients (62.7 +/- 8.5 years old; 58.8% males; N = 500) by 21.6% (from 16.7 +/- 13 to 20.3 +/- 16.4; p < 0.0001) at V2. Ninety-three patients (18.6%) presented a clinically significant HRQoL impairment at V2. To be younger (OR = 0.896; 95% CI 0.829-0.968; p = 0.006), to be a female (OR = 4.181; 95% CI 1.422-12.290; p = 0.009), and to have a greater increase in BDI-II (Beck Depression Inventory-II) (OR = 1.139; 95% CI 1.053-1.231; p = 0.001) and NMSS (Non-Motor Symptoms Scale) (OR = 1.052; 95% CI 1.027-1.113; p < 0.0001) total scores from V0 to V2 were associated with clinically significant HRQoL impairment at the 2-year follow-up (Hosmer-Lemeshow test, p = 0.665; R-2 = 0.655). An increase in >= 5 and >= 10 points of BDI-II and NMSS total score at V2 multiplied the probability of presenting clinically significant HRQoL impairment by 5 (OR = 5.453; 95% CI 1.663-17.876; p = 0.005) and 8 (OR = 8.217; 95% CI, 2.975-22.696; p = 0.002), respectively. In conclusion, age, gender, mood, and non-motor impairment were associated with clinically significant HRQoL impairment after the 2-year follow-up in PD patients.

Published
2021

39. Patient and caregiver outcomes with levodopa-carbidopa intestinal gel in advanced Parkinson's disease

Author

Valldeoriola F, Catalan M, Escamilla-Sevilla F, Freire E, Olivares J, Cubo E, Garcia D, Calopa M, Martinez-Martin P, Parra J, Arroyo G, and Arbelo J

Abstract

Levodopa-carbidopa intestinal gel (LCIG) has shown to be efficacious in motor and non-motor symptoms (NMS). Nevertheless, studies with patient Quality of Life (QoL) as a primary endpoint are scarce. To assess the effect of LCIG on Advanced Parkinson's Disease (APD) patients QoL. Secondarily, the impact on motor symptoms and NMS, emotional well-being, treatment satisfaction, and caregiver QoL, stress, disease burden, anxiety, depression, and work impairment were also investigated. In this prospective, 6-month multicenter postmarketing observational study, LCIG was administered to 59 patients with APD. Endpoints were assessed using validated scales and questionnaires. LOG significantly improved patient QoL (PDQ-39 mean change +/- standard deviation from baseline, -12.8 +/- 14.6; P < 0.0001), motor symptoms (UPDRS-III in "On," -6.5 +/- 11.8; P = 0.0002), NMS (NMSS, -35.7 +/- 31.1; P < 0.0001), mood (Norris/Bond-Lader VAS, -6.6 +/- 21.1; P = 0.0297), fatigue (PFS-16, -0.6 +/- 1.0; P = 0.0003), depression (BDI-II, -5.1 +/- 9.4; P = 0.0002), anxiety (BAI, -6.2 +/- 9.6; P < 0.0001), and patient treatment satisfaction (SATMED-Q, 16.1 +/- 16.8; P < 0.0001). There were significant correlations between the change from baseline to 6 months between PDQ-39 and UPDRS-IV, NMSS, BA', BDI-II, AS, and PFS-16 scores, and Norris/Bond-Lader alertness/sedation factor. Caregiver anxiety also improved (Goldberg anxiety scale, -1.1 +/- 1.0; P = 0.0234), but the clinical relevance of this finding is questionable. The serious adverse events reported were similar to those previously described for LCIG. In patients with APD, LOG improves QoL, motor symptoms and NMS, emotional well-being, and satisfaction with the treatment. Improvement in patient QoL is associated with improvements in motor complications, NMS, anxiety, depression, apathy and fatigue. Improvements in patients' QoL does not correspond with improvements in caregivers' QoL or burden.

Published
2021

43. Sleep Problems Are Related to a Worse Quality of Life and a Greater Non-Motor Symptoms Burden in Parkinson's Disease

Author

Santos-Garcia, D, Castro, E, Fonticoba, T, Panceiras, M, Enriquez, J, Gonzalez, J, Bartolome, C, Planellas, L, Caldentey, J, Caballol, N, Legarda, I, Lopez, I, Manzanares, L, Rivera, M, Catalan, M, Nogueira, V, Borrue, C, Sauco, M, Vela, L, Cubo, E, Castrillo, J, Alonso, P, Losada, M, Ariztegui, N, Gaston, M, Kulisevsky, J, Pagonabarraga, J, Seijo, M, Martinez, J, Valero, C, Kurtis, M, Ardura, J, Prieto, C, Mir, P, Martinez-Martin, P, and COPPADIS Study Grp

Subjects
Parkinson's disease sleep scale, quality of life, Parkinson's disease, sleep, non-motor symptoms
Abstract

Introduction: The aim of the present study was to examine the frequency of self-reported sleep problems and their associated factors in a large cohort of PD patients. Methods: PD patients and controls, recruited from 35 centers of Spain from the COPPADIS cohort were included in this cross-sectional study. Sleep problems were assessed by the Spanish version of the Parkinson's disease Sleep Scale version 1 (PDSS-1). An overall score below 82 or a score below 5 on at least 1 item was defined as sleep problems. Results: The frequency of sleep problems was nearly double in PD patients compared to controls: 65.8% (448/681) vs 33.5% (65/206) (p < 0.0001). Mean total PDSS score was lower in PD patients than controls: 114.9 +/- 28.8 vs 132.8 +/- 16.3 (p < 0.0001). Quality of life (QoL) was worse in PD patients with sleep problems compared to those without: PDQ-39SI, 19.3 +/- 14 vs 13 +/- 11.6 (p < 0.0001); EUROHIS-QoL8, 3.7 +/- 0.5 vs 3.9 +/- 0.5 (p < 0.0001). Non-motor symptoms burden (NMSS; OR = 1.029; 95%CI 1.015-1.043; p < 0.0001) and impulse control behaviors (QUIP-RS; OR = 1.054; 95%CI 1.009-1.101; p = 0.018) were associated with sleep problems after adjustment for age, gender, disease duration, daily equivalent levodopa dose, H&Y, UPDRS-III, UPDRS-IV, PD-CRS, BDI-II, NPI, VAS-Pain, VAFS, FOGQ, and total number of non-antiparkinsonian treatments. Conclusion: Sleep problems were frequent in PD patients and were related to both a worse QoL and a greater non-motor symptoms burden in PD. These findings call for increased awareness of sleep problems in PD patients.

Published
2020

44. Evaluation of surface EMG-based recognition algorithms for decoding hand movements

Author

Abbaspour Asadollah, Sara, Lindén, Maria, GholamHosseini, Hamid, Naber, A., Ortiz-Catalan, M., Abbaspour Asadollah, Sara, Lindén, Maria, GholamHosseini, Hamid, Naber, A., and Ortiz-Catalan, M.

Abstract

Myoelectric pattern recognition (MPR) to decode limb movements is an important advancement regarding the control of powered prostheses. However, this technology is not yet in wide clinical use. Improvements in MPR could potentially increase the functionality of powered prostheses. To this purpose, offline accuracy and processing time were measured over 44 features using six classifiers with the aim of determining new configurations of features and classifiers to improve the accuracy and response time of prosthetics control. An efficient feature set (FS: waveform length, correlation coefficient, Hjorth Parameters) was found to improve the motion recognition accuracy. Using the proposed FS significantly increased the performance of linear discriminant analysis, K-nearest neighbor, maximum likelihood estimation (MLE), and support vector machine by 5.5%, 5.7%, 6.3%, and 6.2%, respectively, when compared with the Hudgins’ set. Using the FS with MLE provided the largest improvement in offline accuracy over the Hudgins feature set, with minimal effect on the processing time. Among the 44 features tested, logarithmic root mean square and normalized logarithmic energy yielded the highest recognition rates (above 95%). We anticipate that this work will contribute to the development of more accurate surface EMG-based motor decoding systems for the control prosthetic hands.

Published
2020
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47. Comparison of two HIV testing strategies in primary care centres: indicator-condition-guided testing vs. testing of those with non-indicator conditions

Author

Menacho, I, Sequeira, E, Muns, M, Barba, O, Leal, L, Clusa, T, Fernandez, E, Moreno, L, Raben, D, Lundgren, J, Gatell, J M, Garcia, F, Cayuelas, L, Aragunde, V, Vergara, M, Catalan, M, Moreno, M A, Hormigo, G, Siso, A, Herreras, Z, Sebastian, L, Benito, L, Picas, A, Hoyo, J, Giner, M J, Cararach, D, Moles, E, Moro, M L, Arrabal, P, Roca, D, Prego, S, Ferrer, X, Egido, A, Ventosa, C, Garcia, S, Muñoz, S, Massana, A, Sole, J, Curiel, M, Heras, F, and Leon, A

Published
2013
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48. Associations between empirical antimicrobial therapy at the hospital and mortality in patients with severe community-acquired pneumonia

Author

Rello, J., Catalan, M., Diaz, E., Bodi, M., and Alvarez, B.

Subjects
Bacterial pneumonia -- Drug therapy, Pneumonia -- Drug therapy, Community-acquired infections -- Drug therapy, Macrolide antibiotics -- Dosage and administration, Health care industry
Abstract

Byline: J. Rello (1), M. Catalan (2), E. Diaz (1), M. Bodi (1), B. Alvarez (3) Keywords: Severe community-acquired pneumonia Antibiotic Treatment Macrolides Abstract: Abstract Introduction. The aim of the study was to examine different antibiotic choices and their relation to outcomes. Methods. We reviewed patients with severe community-acquired pneumonia (SCAP) from two multicenter studies. Empirical antimicrobial regimens were classified as: macrolides alone (group M) macrolides plus betalactams (group MB) macrolides plus betalactam/betalactamase inhibitor (group MBI) every regimen including aminoglycosides (group A) non-pseudomonal third-generation cephalosporins alone (group C) another betalactam alone (first- and second-generation cephalosporins, or betalactam/betalactamase inhibitor) (group B) fluoroquinolones (group F) and other regimens (group Misc). Results. Initial distribution of regimens was: group MB: 261 patients group A: 65 patients group C: 31 patients group B: 23 patients group M: 18 patients group MBI: 13 patients group F: 11 patients group Misc: 38 patients. The lowest overall mortality was associated with initial treatment with a macrolide plus other agent (or alone). No deaths were documented among the 13 patients receiving amoxicillin/clavulanate plus a macrolide. The excess mortality for initial treatment with group A was significantly higher (14.2% CI 95% 27.3--1.1) than the overall mortality rate between patients receiving a macrolide plus other agents. No significant differences were documented when mortality was adjusted for intubated patients. Conclusion. Clinicians select the empirical antibiotic regimen after classifying patients according to likely pathogens and prognosis. The inclusion of a macrolide as part of the initial therapeutic regimen for SCAP appears to be as safe and effective as alternative options. Addition of a macrolide agent to a betalactam/betalactamase inhibitor or using a macrolide alone was a marker for less severe disease. Author Affiliation: (1) Critical Care Department, University Hospital Joan XXIII, Mallafre Guasch 4, 43007 Tarragona (2) Critical Care Department, University Hospital Doce de Octubre, Madrid (3) Critical Care Department, Hospital San Juan, Alicante, Spain Article History: Received Date: 06/11/2001 Accepted Date: 03/04/2002 Article note: Electronic Publication

Published
2002

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