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194 results on '"Catarino, Cristina"'

1. Inhibitor development according to concentrate after 50 exposure days in severe hemophilia: data from the European HAemophilia Safety Surveillance (EUHASS)

Author

Ay, Cihan, Male, Christoph, Hermans, Cedric, Verhamme, Peter, Lissitchkov, Toshko, Antoniades, Marios, Penka, Miroslav, Blatny, Jan, Komrska, Vladimir, Poulsen, Lone Hvitfeldt, Kampmann, Peter, Lehtinen, Anna-Elina, Susen, Sophie, Dargaud, Yesim, Biron, Christine, D'Oiron, Roseline, Harroche, Annie, Klamroth, Robert, Oldenburg, Johannes, Buehrlen, Martina, Miesbach, Wolfgang, Langer, Florian, Spannag, Patrick, Oliveri, Martin, Platokouki, Helen, Nomikou, Efrosyni, Katsarou, Olga, Garypidou, Vasileia, Economou, Marina, Nemes, Laszlo, Nolan, Beatrice, O'Connell, Niamh, Paolo, Radossi, Castaman, Giancarlo, Peyvandi, Flora, Rocino, Angiola, Zanon, Ezio, Tagliaferri, Annarita, Agnelli, Giancarlo, De Crisotofaro, Raimondo, Schinco, Piercarla, Tosetto, Alberto, Lejniece, Sandra, Gailiute, Neringa, Gatt, Alexander, Mäkelburg, Anja, Laros-van Gorkom, Britta, Brons, Paul, Leebeek, Frank W.G., Schutgens, Roger, Windyga, Jerzy, Catarino, Cristina, Aires, Anabela, Fraga, Cristina, Morais, Sara, Araújo, Fernando, Serban, Margit, Davydkin, Igor, Batorova, Angelika, Anzej Doma, Sasa, Martinez, Laura Segura, Palomo Bravo, Angeles, Ortega, Immaculada Soto, Bonanad, Santiago, Baghaei, Fariba, Astermark, Jan, Holmström, Margareta, Fontana, Pierre, Schmugge, Markus, Zulfikar, Bulent, Kavakli, Kaan, Khan, Mohammed, Benson, Gary, Lester, Will, Andrew, Page, Catherine, Bagot, Pinto, Fernando, Salta, Styliani, Farrelly, Cathy, Matthias, Mary, Laffan, Mike, Thynn Thynn, Yee, Mcdonald, Vickie, Austin, Steve, Bella, Madan, Hay, Charles, Grainger, John, Talks, Kate, Shapiro, Susie, Maclean, Rhona, Payne, Jeanette, Fischer, Kathelijn, Lassila, Riitta, Gouw, Samantha C., Hollingsworth, Rob, Lambert, Thierry, Kaczmarek, Radek, Carbonero, Diana, and Makris, Mike

Published
2024
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5. #1358 The association between TNFRSF1B rs1061624 polymorphism and hypertension in end-stage kidney disease patients on dialysis

Author

Coimbra, Susana, primary, Rocha, Susana, additional, Catarino, Cristina, additional, Valente, Maria João, additional, Rocha-Pereira, Petronila, additional, Faria, Maria Do Sameiro, additional, Oliveira, José Gerardo, additional, Fernandes, João, additional, Miranda, Vasco M P, additional, Belo, Luís, additional, Bronze-Da-Rocha, Elsa, additional, and Santos-Silva, Alice, additional

Published
2024
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6. Age-Related Changes in Clinical and Analytical Variables in Chronic Hemodialyzed Patients

Author

Belo, Luís, primary, Valente, Maria João, additional, Rocha, Susana, additional, Coimbra, Susana, additional, Catarino, Cristina, additional, Lousa, Irina, additional, Bronze-da-Rocha, Elsa, additional, Rocha-Pereira, Petronila, additional, Sameiro-Faria, Maria do, additional, Oliveira, José Gerardo, additional, Madureira, José, additional, Fernandes, João Carlos, additional, Miranda, Vasco, additional, Nunes, José Pedro L., additional, and Santos-Silva, Alice, additional

Published
2024
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8. Toxicity Mechanisms of Gadolinium and Gadolinium-Based Contrast Agents-A Review

Author

Coimbra, Susana, Rocha, Susana, Sousa, Nícia Reis, Catarino, Cristina, Belo, Luís, Bronze-da-Rocha, Elsa, Valente, Maria João, Santos-Silva, Alice, Coimbra, Susana, Rocha, Susana, Sousa, Nícia Reis, Catarino, Cristina, Belo, Luís, Bronze-da-Rocha, Elsa, Valente, Maria João, and Santos-Silva, Alice

Abstract

Gadolinium-based contrast agents (GBCAs) have been used for more than 30 years to improve magnetic resonance imaging, a crucial tool for medical diagnosis and treatment monitoring across multiple clinical settings. Studies have shown that exposure to GBCAs is associated with gadolinium release and tissue deposition that may cause short- and long-term toxicity in several organs, including the kidney, the main excretion organ of most GBCAs. Considering the increasing prevalence of chronic kidney disease worldwide and that most of the complications following GBCA exposure are associated with renal dysfunction, the mechanisms underlying GBCA toxicity, especially renal toxicity, are particularly important. A better understanding of the gadolinium mechanisms of toxicity may contribute to clarify the safety and/or potential risks associated with the use of GBCAs. In this work, a review of the recent literature concerning gadolinium and GBCA mechanisms of toxicity was performed.

Published
2024

9. Age-Related Changes in Clinical and Analytical Variables in Chronic Hemodialyzed Patients

Author

Belo, Luís, Valente, Maria João, Rocha, Susana, Coimbra, Susana, Catarino, Cristina, Lousa, Irina, Bronze-da-Rocha, Elsa, Rocha-Pereira, Petronila, Sameiro-Faria, Maria do, Oliveira, José Gerardo, Madureira, José, Fernandes, João Carlos, Miranda, Vasco, Nunes, José Pedro L., Santos-Silva, Alice, Belo, Luís, Valente, Maria João, Rocha, Susana, Coimbra, Susana, Catarino, Cristina, Lousa, Irina, Bronze-da-Rocha, Elsa, Rocha-Pereira, Petronila, Sameiro-Faria, Maria do, Oliveira, José Gerardo, Madureira, José, Fernandes, João Carlos, Miranda, Vasco, Nunes, José Pedro L., and Santos-Silva, Alice

Abstract

Worldwide, the number of elderly individuals receiving chronic hemodialysis is rising. The aim of our study was to evaluate several clinical and analytical biomarkers in chronically dialyzed patients and analyze how they change with age. A cross-sectional study was performed by evaluating 289 end-stage renal disease patients undergoing dialysis. We evaluated the hemogram, adipokines, the lipid profile, and several markers related to inflammation, endothelial function/fibrinolysis, nutrition, iron metabolism, and cardiac and renal fibrosis. Clinical data and dialysis efficacy parameters were obtained from all patients. The relationships between studied biomarkers and age were assessed by a statistical comparison between younger (adults with age < 65 years) and older (age ≥ 65 years) patients and by performing regression analysis. Participants presented a mean age of 68.7 years (±13.6), with 66.8% (n = 193) being classified as older. Compared to younger patients, older patients presented the following: (a) significantly lower values of diastolic blood pressure (DBP) and ultrafiltration volume; (b) lower levels of phosphorus, uric acid, creatinine, and albumin; and (c) higher circulating concentrations of tissue-type plasminogen activator (tPA), D-dimer, interleukin-6, leptin, N-terminal pro B-type natriuretic peptide, and tissue inhibitor of metalloproteinase-1. In the multiple linear regression analysis, DBP values, tPA, phosphorus, and D-dimer levels were independently associated with the age of patients (standardized betas: −0.407, 0.272, −0.230, and 0.197, respectively; p < 0.001 for all), demonstrating relevant changes in biomarkers with increasing age at cardiovascular and nutritional levels. These findings seem to result from crosstalk mechanisms between aging and chronic kidney disease.

Published
2024

10. Impact of TNFRSF1B (rs3397, rs1061624 and rs1061622) and IL6 (rs1800796, rs1800797 and rs1554606) Gene Polymorphisms on Inflammatory Response in Patients with End-Stage Kidney Disease Undergoing Dialysis.

Author

Coimbra, Susana, Rocha, Susana, Catarino, Cristina, Valente, Maria João, Rocha-Pereira, Petronila, Sameiro-Faria, Maria, Oliveira, José Gerardo, Madureira, José, Fernandes, João Carlos, Miranda, Vasco, Belo, Luís, Bronze-da-Rocha, Elsa, and Santos-Silva, Alice

Subjects
CHRONIC kidney failure, GENETIC polymorphisms, INTERLEUKIN-6, TUMOR necrosis factors, INFLAMMATION, BLOOD cell count, POLYMORPHISM (Crystallography)
Abstract

We aimed to study the impact of polymorphisms in the genes encoding interleukin-6 (IL6) and tumor necrosis factor receptor-2 (TNFR2), reported to be mortality risk predictors, in patients with end-stage kidney disease (ESKD) undergoing dialysis. TNFRSF1B (rs3397, rs1061624, and rs1061622) and IL6 (rs1800796, rs1800797, and rs1554606) polymorphisms were studied in patients with ESKD and controls; the genotype and allele frequencies and the associations with inflammatory and erythropoiesis markers were determined; deaths were recorded throughout the following two years. The genotype and allele frequencies for the TNFRSF1B rs3397 polymorphism were different in these patients compared to those in the controls and the global and European populations, and patients with the C allele were less common. Patients with the CC genotype for TNFRSF1B rs3397 presented higher hemoglobin and erythrocyte counts and lower TNF-α levels, suggesting a more favorable inflammatory response that seems to be associated with erythropoiesis improvement. Patients with the GG genotype for TNFRSF1B rs1061622 showed lower serum ferritin levels. None of the TNFRSF1B (rs3397, rs1061624, and rs1061622) or IL6 (rs1800796, rs1800797, and rs1554606) polymorphisms had a significant impact on the all-cause mortality rate of Portuguese patients with ESKD. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Cross-sectional epidemiological study to understand the approach to treatment in the routine care of patients with hemophilia B in Spain and Portugal

Author

Álvarez-Román, María T., primary, Carvalho, Manuela, additional, Benítez-Hidalgo, Olga, additional, Catarino, Cristina, additional, García-Frade, Luis J., additional, Rodríguez-López, Manuel, additional, Antunes, Margarida, additional, Fernández-Mosteirín, Nuria, additional, Kjöllerström, Paula, additional, Morais, Sara, additional, Galmes, Bernat, additional, López-Fernández, María F., additional, Riera-Sans, Lluis, additional, Rodrigues, Joana F., additional, Jiménez-Yuste, Víctor, additional, and Salvado, Ramón, additional

Published
2023
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13. Using pharmacokinetics for tailoring prophylaxis in people with hemophilia switching between clotting factor products: A scoping review

Author

Yu, Jacky K., Iorio, Alfonso, Edginton, Andrea N., Ahuja, Sanjay, Álvarez Román, Ma Teresa, Arrieta, Ma E., Arola, Mikko, Barillari, Giovanni, Balasa, Vinod, Belletrutti, Mark, Berrueco Moreno, Ruben, Beurrier, Philippe, Bidlingmaier, Cristoph, Blanchette, Victor, Blatny, Jan, Bonanad, Santiago, Brose, Kelsey, Brown, Deborah, Byant, Paulette C., Canaro, Mariana, Carvalho, Manuela, Catarino, Cristina, Chitlur, Meera, Cockrell, Erin, Chowdary, Pratima, Cnossen, Marjon, Collins, Peter, Coppens, Michial, Croteau, Stacy, Cultrera, Dorina, de Cristofaro, Raimundo, de Raucourt, Emmauelle, Desprez, Dominique, Dunn, Amy, El‐Ekiabi, Magda, Faganel Kotnik, Barbara, Fischer, Kathleen, Frotscher, Brigit, Garbiero, Susana, Garrido Ruiz, Raquel, Gill, Joan, Gomez del Castillo, Carmen, Gottstein, Saskia, Lassandro, Giuseppe, Giordano, Paola, Hart, Daniel, Hegemann, Inga, Hermans, Cedric, Hua, Baolai, Hwang, Nina, Jackson, Shannon, James, Paula, Katsarou, Olga, Kavakli, Kaan, Kempton, Christine, Kentouche, Karim, Khan, Osman, Kobelt, Rainer, Kruse‐Jarres, Rebecca, Laane, Edward, Larson, Eric, Lassila, Riitta, Lee, Adrienne, Poon, Man‐Chiu, Lissick, Jennifer, Langstrom, Satu, Mahlangu, Johnny, Makris, Michael, Marchesini, Emmanuela, Mateo, Jose, Marco Vera, Pacual, Martorell, Marta, Matsushita, Tadashi, McCrae, Simon, Mignot‐Castellano, Eva, Montcrieff, Caitlin, Maes, Philip, Mondelars, Veerle, Bekart, Marlies, Mora, Elena, Cristóbal Morales, Juan, Mourey, Guillaume, Bertrand, Marie Ann, Napolitano, Mariasanta, Siragusa, Sergio, Negrier, Claude, Neme, Daniela, Niinimaki, Ritta, Oldenburg, Johannes, Albert, Thilo, Ornstein, Deborah, Ozelo, Margarete, Panetta, John Carl, Neufeld, Ellis J., P'Ng, Stephanie, Peerlinck, Kathelijne, Pollio, Berardino, Pouplard, Claire, Gruel, Yves, Prezotti, Alessandra, Price, Vicky, Primacakti, Fitri, Puyade, Mathieu, Radossi, Paolo, Raffini, Leslie, Ragni, Margaret, Rangarajan, Savita, Reding, Mark T., Reid, Robin, Restrepo, Jose, Ramirez, Jose, Recht, Michael, Rodriguez Lopez, Manuel, Ruiz‐Sàez, Arlette, Saleh, Mahasen, Shapiro, Amy, Sharathkumar, Anjali, Selmeczi, Anna, Simpson, Mindy, Singleton, Tami, Cruz, Maria Sol, Soto, Veronica, Steele, MacGregor, Streif, Werner, Sun, Hao Wei, Ritchie, Bruce, Sun, Jing, Feng, Xiaqin, Suzuki, Takashi, Nagao, Asuza, Takemoto, Cliff, Tapp, Heather, Teitel, Jerry, Tinmouth, Alan, Thornburg, Courtney, Tosseto, Alberto, Turnstall, Oliver, Vezina, Catherine, Warren, Beth, Wheeler, Allison, Wilches Gutierrez, Juan D., Wu, John K.M., Wynn, Tung, Yang, Renchi, Young, Guy, Zanon, Ezio, and Zupan, Irena

Published
2019
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15. #4713 TUMOR NECROSIS FACTOR RECEPTOR 2 POLYMORPHISM (RS1061622) AND INFLAMMATORY RESPONSE IN END-STAGE RENAL DISEASE PATIENTS UNDER DIALYSIS

Author

Coimbra, Susana, primary, Rocha, Susana, additional, Catarino, Cristina, additional, Valente, Maria João, additional, Rocha-Pereira, Petronila, additional, Faria, Maria Do Sameiro, additional, Oliveira, José Gerardo, additional, Madureira, José, additional, Fernandes, João, additional, Miranda, Vasco M P, additional, Bronze-Da-Rocha, Elsa, additional, Belo, Luís, additional, and Santos-Silva, Alice, additional

Published
2023
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17. The Association of Leptin with Left Ventricular Hypertrophy in End-Stage Kidney Disease Patients on Dialysis

Author

Coimbra, Susana, primary, Catarino, Cristina, additional, Sameiro Faria, Maria, additional, Nunes, José Pedro L., additional, Rocha, Susana, additional, Valente, Maria João, additional, Rocha-Pereira, Petronila, additional, Bronze-da-Rocha, Elsa, additional, Bettencourt, Nuno, additional, Beco, Ana, additional, Marques, Sofia Homem de Melo, additional, Oliveira, José Gerardo, additional, Madureira, José, additional, Fernandes, João Carlos, additional, Miranda, Vasco, additional, Belo, Luís, additional, and Santos-Silva, Alice, additional

Published
2023
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18. The Association of Leptin with Left Ventricular Hypertrophy in End-Stage Kidney Disease Patients on Dialysis

Author

Coimbra, Susana, Catarino, Cristina, Faria, Maria Sameiro, Nunes, José Pedro L., Rocha, Susana, Valente, Maria João, Rocha-Pereira, Petronila, Bronze-da-Rocha, Elsa, Bettencourt, Nuno, Beco, Ana, Marques, Sofia Homem de Melo, Oliveira, José Gerardo, Madureira, José, Fernandes, João Carlos, Miranda, Vasco, Belo, Luís, Santos-Silva, Alice, Coimbra, Susana, Catarino, Cristina, Faria, Maria Sameiro, Nunes, José Pedro L., Rocha, Susana, Valente, Maria João, Rocha-Pereira, Petronila, Bronze-da-Rocha, Elsa, Bettencourt, Nuno, Beco, Ana, Marques, Sofia Homem de Melo, Oliveira, José Gerardo, Madureira, José, Fernandes, João Carlos, Miranda, Vasco, Belo, Luís, and Santos-Silva, Alice

Abstract

Left ventricular hypertrophy (LVH) is a common cardiovascular complication in end-stage kidney disease (ESKD) patients. We aimed at studying the association of LVH with adiponectin and leptin levels, cardiovascular stress/injury biomarkers and nutritional status in these patients. We evaluated the LV mass (LVM) and calculated the LVM index (LVMI) in 196 ESKD patients on dialysis; the levels of hemoglobin, calcium, phosphorus, parathyroid hormone, albumin, adiponectin, leptin, N-terminal pro B-type natriuretic peptide (NT-proBNP) and growth differentiation factor (GDF)-15 were analyzed. ESKD patients with LVH (n = 131) presented higher NT-proBNP and GDF-15, lower hemoglobin and, after adjustment for gender, lower leptin levels compared with non-LVH patients. LVH females also showed lower leptin than the non-LVH female group. In the LVH group, LVMI presented a negative correlation with leptin and a positive correlation with NT-proBNP. Leptin emerged as an independent determinant of LVMI in both groups, and NT-proBNP in the LVH group. Low hemoglobin and leptin and increased calcium, NT-proBNP and dialysis vintage are associated with an increased risk of developing LVH. In ESKD patients on dialysis, LVH is associated with lower leptin values (especially in women), which are negatively correlated with LVMI, and with higher levels of biomarkers of myocardial stress/injury. Leptin and NT-proBNP appear as independent determinants of LVMI; dialysis vintage, hemoglobin, calcium, NT-proBNP and leptin emerged as predicting markers for LVH development. Further studies are needed to better understand the role of leptin in LVH in ESKD patients.

Published
2023

19. Bile acids profile and redox status in healthy infants

Author

Santos Silva, Ermelinda, primary, Rocha, Susana, additional, Candeias Ramos, Rita, additional, Coutinho, Helena, additional, Catarino, Cristina, additional, Teixeira, Fernanda, additional, Henriques, Graça, additional, Lopes, Ana Isabel, additional, Santos-Silva, Alice, additional, and Brites, Dora, additional

Published
2022
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21. New Insights into Adiponectin and Leptin Roles in Chronic Kidney Disease

Author

Coimbra, Susana, Rocha, Susana, Valente, Maria João, Catarino, Cristina, Bronze-da-Rocha, Elsa, Belo, Luís, Santos-Silva, Alice, Coimbra, Susana, Rocha, Susana, Valente, Maria João, Catarino, Cristina, Bronze-da-Rocha, Elsa, Belo, Luís, and Santos-Silva, Alice

Abstract

Chronic kidney disease (CKD) is commonly associated with a high burden of comorbidities and poor clinical outcomes. Malnutrition–inflammation–atherosclerosis syndrome is common in the more severe stages of CKD, suggesting a close interplay for these three comorbid conditions. Both malnutrition and obesity are associated with a disturbed adipokine profile and inflammation, contributing to a higher risk of cardiovascular disease (CVD) events. Adiponectin and leptin have important roles in carbohydrate and lipid metabolism, and in the inflammatory process. The effects of adiponectin and leptin alterations in CKD, which are usually increased, and their association with the different comorbidities found in CKD, will be focused on to understand their crosstalk with the risk of CVD events. Nonetheless, although adiponectin and leptin contribute to a higher risk of CVD events, further studies are warranted to fully clarify their roles, especially when different comorbidities exist.

Published
2022

27. MO810INTERLEUKIN-6 (-174G/C) POLYMORPHISM, RS1800795, IN ESRD PATIENTS' OUTCOME*

Author

Rocha, Susana, primary, Valente, Maria João, additional, Coimbra, Susana, additional, Catarino, Cristina, additional, Rocha-Pereira, Petronila, additional, Oliveira, José Gerardo, additional, Madureira, José, additional, Fernandes, João Carlos, additional, Faria, Maria do Sameiro, additional, Miranda, Vasco M P, additional, Belo, Luís, additional, Santos-Silva, Alice, additional, and Bronze-da-Rocha, Elsa, additional

Published
2021
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28. MO472A PRELIMINARY STUDY OF POTENTIAL BIOMARKERS FOR EARLY DIAGNOSIS IN CHRONIC KIDNEY DISEASE

Author

Lousa, Irina, primary, Valente, Maria João, additional, Rocha, Susana, additional, D. Viana, Sofia, additional, Preguiça, Inês, additional, Mira, Filipe, additional, Nogueira, Rui, additional, Coimbra, Susana, additional, Catarino, Cristina, additional, Rocha-Pereira, Petronila, additional, Bronze-da-Rocha, Elsa, additional, Faria, Maria do Sameiro, additional, Alves, Rui, additional, Beirão, Idalina, additional, Reis, Flávio, additional, Belo, Luís, additional, and Santos-Silva, Alice, additional

Published
2021
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29. MO735INTERPLAY BETWEEN GDF-15 AND LEFT VENTRICULAR HYPERTROPHY IN END-STAGE RENAL DISEASE PATIENTS ON DIALYSIS

Author

Coimbra, Susana, primary, Catarino, Cristina, additional, Faria, Maria do Sameiro, additional, Lopes Nunes, José Pedro, additional, Rocha, Susana, additional, Valente, Maria João, additional, Rocha-Pereira, Petronila, additional, Bronze-da-Rocha, Elsa, additional, Bettencourt, Nuno, additional, Beco, Ana, additional, Homem Melo Marques, Sofia, additional, Oliveira, José Gerardo, additional, Madureira, José, additional, Miranda, Vasco M P, additional, Belo, Luís, additional, and Santos-Silva, Alice, additional

Published
2021
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31. Interleukin 6 (rs1800795) and Pentraxin 3 (rs2305619) Polymorphisms - Association with Inflammation and All-Cause Mortality in End-stage-renal Disease Patients on Dialysis

Author

Rocha, Susana, primary, Valente, Maria João, additional, Coimbra, Susana, additional, Catarino, Cristina, additional, Rocha-Pereira, Petronila, additional, Oliveira, José Gerardo, additional, Madureira, José, additional, Fernandes, João Carlos, additional, Sameiro-Faria, Maria, additional, Miranda, Vasco, additional, Belo, Luís, additional, Santos-Silva, Alice, additional, and Bronze-da-Rocha, Elsa, additional

Published
2021
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33. Cell-free DNA as a marker for the outcome of end-stage renal disease patients on haemodialysis

Author

Coimbra, Susana, primary, Rocha, Susana, additional, Nascimento, Henrique, additional, Valente, Maria João, additional, Catarino, Cristina, additional, Rocha-Pereira, Petronila, additional, Sameiro-Faria, Maria, additional, Oliveira, José Gerardo, additional, Madureira, José, additional, Fernandes, João Carlos, additional, Miranda, Vasco, additional, Belo, Luís, additional, Bronze-da-Rocha, Elsa, additional, and Santos-Silva, Alice, additional

Published
2020
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34. P1531DIURETIC USE IN HEMODIALYSIS PATIENTS: BENEFIC ASSOCIATION WITH RESIDUAL RENAL FUNCTION AND ALL-CAUSE MORTALITY

Author

Faria, Maria do Sameiro, primary, Valente, Maria João, primary, Rocha, Susana, primary, Coimbra, Susana, primary, Catarino, Cristina, primary, Rocha-Pereira, Petronila, primary, Bronze-da-Rocha, Elsa, primary, Oliveira, José Gerardo, primary, Madureira, José, primary, Fernandes, João Carlos, primary, Miranda, Vasco M P, primary, Belo, Luís, primary, and Santos-Silva, Alice, primary

Published
2020
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35. P1570INTERLEUKIN-6 (RS1800795) AND PENTRAXIN 3 (RS2305619) GENETIC POLYMORPHISMS AND THEIR RELATION WITH INFLAMMATION AND ALL-CAUSE MORTALITY IN ESRD PATIENTS ON DIALYSIS

Author

Rocha, Susana, primary, Valente, Maria João, primary, Coimbra, Susana, primary, Catarino, Cristina, primary, Rocha-Pereira, Petronila, primary, Faria, Maria do Sameiro, primary, Oliveira, José Gerardo, primary, Madureira, José, primary, Fernandes, João Carlos, primary, Miranda, Vasco M P, primary, Belo, Luís, primary, Santos-Silva, Alice, primary, and Bronze-da-Rocha, Elsa, primary

Published
2020
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36. P1263ASSOCIATION OF LEFT VENTRICULAR HYPERTROPHY AND ADIPOCYTOKINES IN PATIENTS ON DIALYSIS

Author

Catarino, Cristina, primary, Faria, Maria do Sameiro, primary, Lopes Nunes, José Pedro, primary, Rocha, Susana, primary, Valente, Maria João, primary, Coimbra, Susana, primary, Rocha-Pereira, Petronila, primary, Bronze-da-Rocha, Elsa, primary, Bettencourt, Nuno, primary, Beco, Ana, primary, Homem Melo Marques, Sofia, primary, Oliveira, José Gerardo, primary, Madureira, José, primary, Miranda, Vasco M P, primary, Belo, Luís, primary, and Santos-Silva, Alice, primary

Published
2020
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37. P1581IMPACT OF ACHIEVING LDL CHOLESTEROL LOWER THAN 100 MG/DL WITH STATINS, ON LIPID PROFILE AND INFLAMMATION IN END-STAGE RENAL DISEASE PATIENTS

Author

Coimbra, Susana, primary, Reis, Flávio, primary, Nunes, Sara, primary, D. Viana, Sofia, primary, Valente, Maria João, primary, Rocha, Susana, primary, Catarino, Cristina, primary, Rocha-Pereira, Petronila, primary, Bronze-da-Rocha, Elsa, primary, Oliveira, José Gerardo, primary, Madureira, José, primary, Fernandes, João Carlos, primary, Faria, Maria do Sameiro, primary, Miranda, Vasco M P, primary, Belo, Luís, primary, and Santos-Silva, Alice, primary

Published
2020
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38. P0739PANEL OF SENSITIVE BIOMARKERS OF THE PRIMARY RESPONSE TO RENAL INJURY FOR AN EARLY DIAGNOSIS OF CHRONIC KIDNEY DISEASE

Author

Valente, Maria João, primary, Rocha, Susana, primary, Lousa, Irina, primary, Reis, Flávio, primary, Nunes, Sara, primary, D. Viana, Sofia, primary, Preguiça, Inês, primary, Mira, Filipe, primary, Nogueira, Rui, primary, Coimbra, Susana, primary, Catarino, Cristina, primary, Rocha-Pereira, Petronila, primary, Bronze-da-Rocha, Elsa, primary, Faria, Maria do Sameiro, primary, Alves, Rui, primary, Santos, Sofia, primary, Correia, Sofia, primary, Beirão, Idalina, primary, Belo, Luís, primary, and Santos-Silva, Alice, primary

Published
2020
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42. Effects of statins therapy on LDL subfractions and inflammation in end-stage renal disease patients on dialysis

Author

Coimbra, Susana, Reis, Flávio, Nunes, Sara, Viana, Sofia, Valente, Maria João, Rocha, Susana, Catarino, Cristina, Rocha-Pereira, Petronila, Bronze-da-Rocha, Elsa, Oliveira, José Gerardo, Madureira, José, Fernandes, João Carlos, Do Sameiro-Faria, Maria, Miranda, Vasco, Belo, Luís, and Santos-Silva, Alice

Subjects
Inflammation, Inflamação, Falência renal crónica, Statins, Lipoproteínas LDL, Inibidores de Hidroximetilglutaril-CoA Redutases, End stage renal disease, LDL
Abstract

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Published
2019

43. Impact of a School-Based Intervention Protocol--ACORDA Project--On Adipokines in an Overweight and Obese Pediatric Population.

Author

Nascimento, Henrique, Alves, Ana Inês, Medeiros, Ana Filipa, Coimbra, Susana, Catarino, Cristina, Bronze-da-Rocha, Elsa, Costa, Elísio, Rocha-Pereira, Petronila, Silva, Gustavo, Aires, Luísa, Seabra, André, Mota, Jorge, Mansilha, Helena Ferreira, Rêgo, Carla, Santos-Silva, Alice, and Belo, Luis

Subjects
TREATMENT of childhood obesity, BLOOD sugar, BODY composition, C-reactive protein, CHI-squared test, CHOLESTEROL, FISHER exact test, GROWTH factors, HEART beat, HIGH density lipoproteins, INFLAMMATION, INSULIN, INTERLEUKINS, LONGITUDINAL method, LOW density lipoproteins, NUTRITION counseling, CHILDHOOD obesity, PHYSICAL education, PROBABILITY theory, RESEARCH funding, STATISTICAL hypothesis testing, STATISTICS, T-test (Statistics), TRIGLYCERIDES, TUMOR necrosis factors, LEPTIN, DATA analysis, BODY mass index, TREATMENT effectiveness, OXYGEN consumption, DATA analysis software, WAIST circumference, MANN Whitney U Test, DISEASE complications
Abstract

Purpose: There are few reliable studies assessing the effect of physical exercise (PE) on adipokines levels at young ages. Our objective was to study the effects of regular PE on plasma adipokines in pediatric overweight and obesity. Method. 117 overweight and obese children and adolescents (47% females; 10.2 years) participated in an 8-month longitudinal study divided in two groups: PE group (n = 80), engaged in an after-school PE program; control group (n = 37), with no PE program. Plasma lipids, C-reactive protein (CRP), adiponectin, resistin, leptin, IL-6, IL-lbeta, TNF-alpha, insulin and glucose levels were determined. Results, contrarily to the control group, the PE group presented reductions in body mass index z-score (BMIzsc) and body fat percentage that were accompanied by an improvement in lipid profile and insulin resistance, a reduction in CRP and TNF-alpha and an increase in adiponectin levels. The reductions in BMIzsc were inversely correlated with changes in adiponectin (r=-0.329, p - .003) and positively correlated with changes in percentage body fat (r = .262, p = .032), triglycerides (r = .228, p = .042) and leptin (r = .285, p = .010). Conclusions. Moderate reductions in adiposity improve proinflammatory status in obese children and adolescents. A more substantial reduction in BMIzsc was associated with a greater increment in adiponeclin and reduction in leptin. [ABSTRACT FROM AUTHOR]

Published
2016
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45. Cell-free DNA as a marker for the outcome of end-stage renal disease patients on haemodialysis.

Author

Coimbra, Susana, Rocha, Susana, Nascimento, Henrique, Valente, Maria João, Catarino, Cristina, Rocha-Pereira, Petronila, Sameiro-Faria, Maria, Oliveira, José Gerardo, Madureira, José, Fernandes, João Carlos, Miranda, Vasco, Belo, Luís, Bronze-da-Rocha, Elsa, and Santos-Silva, Alice

Subjects
CHRONIC kidney failure, HEMODIALYSIS patients, GENETIC markers, DNA damage, OXIDATIVE stress
Abstract

Background DNA damage and inflammation are common in end-stage renal disease (ESRD). Our aim was to evaluate the levels of circulating cell-free DNA (cfDNA) and the relationship with inflammation, anaemia, oxidative stress and haemostatic disturbances in ESRD patients on dialysis. By performing a 1-year follow-up study, we also aimed to evaluate the predictive value of cfDNA for the outcome of ESRD patients. Methods A total of 289 ESRD patients on dialysis were enrolled in the study: we evaluated cfDNA, haemogram, serum iron, hepcidin, inflammatory and oxidative stress markers, and haemostasis. Events and causes of deaths were recorded throughout the follow-up period. Results ESRD patients, as compared with controls, presented significantly higher levels of cfDNA, hepcidin, and inflammatory and oxidative stress markers, and significantly lower values of iron and anaemia-related haemogram parameters. The all-cause mortality rate was 9.7%; compared with alive patients, deceased patients (n  =   28) were older and presented significantly higher values of inflammatory markers and of cfDNA, which was almost 2-fold higher. Furthermore, cfDNA was the best predictor of all-cause mortality and cardiovascular mortality in ESRD patients, in both unadjusted and adjusted models for basic confounding factors in dialysis. Conclusions Our data show cfDNA to be a valuable predictive marker of prognosis in ESRD patients on dialysis treatment; high levels of cfDNA were associated with a poor outcome. [ABSTRACT FROM AUTHOR]

Published
2021
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46. Long Pentraxin 3 as a Broader Biomarker for Multiple Risk Factors in End-Stage Renal Disease: Association with All-Cause Mortality

Author

Valente, Maria João, primary, Rocha, Susana, additional, Coimbra, Susana, additional, Catarino, Cristina, additional, Rocha-Pereira, Petronila, additional, Bronze-da-Rocha, Elsa, additional, Oliveira, José Gerardo, additional, Madureira, José, additional, Fernandes, João Carlos, additional, do Sameiro-Faria, Maria, additional, Miranda, Vasco, additional, Belo, Luís, additional, and Santos-Silva, Alice, additional

Published
2019
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47. SP666MACHINE LEARNING IN PREDICTION OF VULNERABLE OR RESILIENT END-STAGE RENAL DISEASE PATIENTS

Author

Pedroso, João Pedro, primary, Valente, Maria João, additional, Rocha, Susana, additional, Coimbra, Susana, additional, Catarino, Cristina, additional, Rocha-Pereira, Petronila, additional, Bronze-Da-Rocha, Elsa, additional, Carvalho, Márcia, additional, Oliveira, José Gerardo, additional, Madureira, José, additional, Fernandes, João Carlos, additional, Do Sameiro-Faria, Maria, additional, Miranda, Vasco, additional, Belo, Luís, additional, and Santos-Silva, Alice, additional

Published
2019
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48. SP543ASSOCIATION OF PTX3, NT-proBNP AND LEFT VENTRICULAR HYPERTROPHY IN PATIENTS ON DIALYSIS

Author

Catarino, Cristina, primary, Rocha, Susana, additional, Valente, Maria João, additional, Coimbra, Susana, additional, Rocha-Pereira, Petronila, additional, Bronze-Da-Rocha, Elsa, additional, Sá-Fernandes, Vitor, additional, Santos-Martins, Miguel, additional, Bettencourt, Nuno, additional, Nunes, José Pedro, additional, Beco, Ana, additional, Marques, Sofia M, additional, Do Sameiro-Faria, Maria, additional, Miranda, Vasco, additional, Belo, Luís, additional, and Santos-Silva, Alice, additional

Published
2019
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49. FP725PENTRAXIN 3 IN END-STAGE RENAL DISEASE: MULTIPLE RISK BIOMARKER AND PREDICTOR OF ALL-CAUSE MORTALITY

Author

Valente, Maria João, primary, Rocha, Susana, additional, Coimbra, Susana, additional, Catarino, Cristina, additional, Rocha-Pereira, Petronila, additional, Bronze-Da-Rocha, Elsa, additional, Oliveira, José Gerardo, additional, Madureira, José, additional, Fernandes, João Carlos, additional, Do Sameiro-Faria, Maria, additional, Miranda, Vasco, additional, Belo, Luís, additional, and Santos-Silva, Alice, additional

Published
2019
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50. FP730EFFECTS OF STATINS THERAPY ON LDL SUBFRACTIONS AND INFLAMMATION, IN END-STAGE RENAL DISEASE PATIENTS ON DIALYSIS

Author

Coimbra, Susana, primary, Reis, Flávio, additional, Nunes, Sara, additional, Viana, Sofia, additional, Valente, Maria João, additional, Rocha, Susana, additional, Catarino, Cristina, additional, Rocha-Pereira, Petronila, additional, Bronze-Da-Rocha, Elsa, additional, Oliveira, José Gerardo, additional, Madureira, José, additional, Fernandes, João Carlos, additional, Do Sameiro-Faria, Maria, additional, Miranda, Vasco, additional, Belo, Luís, additional, and Santos-Silva, Alice, additional

Published
2019
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