7 results on '"Catecholamines -- Genetic aspects"'
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2. Genotype link with extreme antisocial behavior: the contribution of cognitive pathways
- Author
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Langley, Kate, Heron, Jon, O'Donovan, Michael C., Owen, Michael J., and Thapar, Anita
- Subjects
Antisocial behavior -- Genetic aspects ,Antisocial behavior -- Risk factors ,Antisocial behavior -- Research ,Cognition -- Genetic aspects ,Cognition -- Research ,Catecholamines -- Genetic aspects ,Catecholamines -- Research ,Methyltransferases -- Genetic aspects ,Methyltransferases -- Research ,Health ,Psychology and mental health - Published
- 2010
3. Drosophila dopamine synthesis pathway genes regulate tracheal morphogenesis
- Author
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Hsouna, Anita, Lawal, Hakeem O., Izevbaye, Iyare, Hsu, Tien, and O'Donnell, Janis M.
- Subjects
Catecholamines -- Genetic aspects ,Genetic research -- Genetic aspects ,Drosophila -- Genetic aspects ,Biological sciences - Abstract
To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ydbio.2007.04.047 Byline: Anita Hsouna (a), Hakeem O. Lawal (b), Iyare Izevbaye (b), Tien Hsu (a), Janis M. O'Donnell (b) Keywords: Drosophila; Trachea; Dopamine; Punch; Pale; Catsup; Breathless; Endocytosis; GTP cyclohydrolase; Tyrosine hydroxylase Abstract: While studying the developmental functions of the Drosophila dopamine synthesis pathway genes, we noted interesting and unexpected mutant phenotypes in the developing trachea, a tubule network that has been studied as a model for branching morphogenesis. Specifically, Punch (Pu) and pale (ple) mutants with reduced dopamine synthesis show ectopic/aberrant migration, while Catecholamines up (Catsup) mutants that over-express dopamine show a characteristic loss of migration phenotype. We also demonstrate expression of Punch, Ple, Catsup and dopamine in tracheal cells. The dopamine pathway mutant phenotypes can be reproduced by pharmacological treatments of dopamine and a pathway inhibitor 3-iodotyrosine (3-IT), implicating dopamine as a direct mediator of the regulatory function. Furthermore, we show that these mutants genetically interact with components of the endocytic pathway, namely shibire/dynamin and awd/nm23, that promote endocytosis of the chemotactic signaling receptor Btl/FGFR. Consistent with the genetic results, the surface and total cellular levels of a Btl-GFP fusion protein in the tracheal cells and in cultured S2 cells are reduced upon dopamine treatment, and increased in the presence of 3-IT. Moreover, the transducer of Btl signaling, MAP kinase, is hyper-activated throughout the tracheal tube in the Pu mutant. Finally we show that dopamine regulates endocytosis via controlling the dynamin protein level. Author Affiliation: (a) Department of Pathology and Laboratory Medicine, and Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA (b) Department of Biological Sciences, University of Alabama, Tuscaloosa, AL 35487, USA Article History: Received 15 January 2007; Revised 16 April 2007; Accepted 30 April 2007
- Published
- 2007
4. Atypical antipsychotics and weight gain
- Subjects
Methyl aspartate -- Surveys ,Methyl aspartate -- Reports ,Methyl aspartate -- Genetic aspects ,Medical research -- Surveys ,Medical research -- Reports ,Medical research -- Genetic aspects ,Medicine, Experimental -- Surveys ,Medicine, Experimental -- Reports ,Medicine, Experimental -- Genetic aspects ,Dextrose -- Surveys ,Dextrose -- Reports ,Dextrose -- Genetic aspects ,Glucose -- Surveys ,Glucose -- Reports ,Glucose -- Genetic aspects ,Catecholamines -- Surveys ,Catecholamines -- Reports ,Catecholamines -- Genetic aspects ,Eating disorders -- Prevention ,Eating disorders -- Surveys ,Eating disorders -- Reports ,Eating disorders -- Genetic aspects ,Anticonvulsants -- Statistics ,Anticonvulsants -- Surveys ,Anticonvulsants -- Reports ,Anticonvulsants -- Genetic aspects ,Nizatidine -- Statistics ,Nizatidine -- Surveys ,Nizatidine -- Reports ,Nizatidine -- Genetic aspects ,RNA -- Surveys ,RNA -- Reports ,RNA -- Genetic aspects ,Fructose -- Surveys ,Fructose -- Reports ,Fructose -- Genetic aspects ,Histamine receptors -- Surveys ,Histamine receptors -- Reports ,Histamine receptors -- Genetic aspects ,Histamine -- Surveys ,Histamine -- Reports ,Histamine -- Genetic aspects ,GABA -- Surveys ,GABA -- Reports ,GABA -- Genetic aspects ,Lipase -- Surveys ,Lipase -- Reports ,Lipase -- Genetic aspects ,ACTH -- Surveys ,ACTH -- Reports ,ACTH -- Genetic aspects ,Fluoxetine -- Statistics ,Fluoxetine -- Surveys ,Fluoxetine -- Reports ,Fluoxetine -- Genetic aspects ,Glucose metabolism -- Surveys ,Glucose metabolism -- Reports ,Glucose metabolism -- Genetic aspects ,Hormones -- Surveys ,Hormones -- Reports ,Hormones -- Genetic aspects ,Neuropeptides -- Surveys ,Neuropeptides -- Reports ,Neuropeptides -- Genetic aspects ,Blood lipids -- Surveys ,Blood lipids -- Reports ,Blood lipids -- Genetic aspects ,Weight loss -- Prevention ,Weight loss -- Surveys ,Weight loss -- Reports ,Weight loss -- Genetic aspects ,Diabetes therapy -- Statistics ,Diabetes therapy -- Surveys ,Diabetes therapy -- Reports ,Diabetes therapy -- Genetic aspects ,Antipsychotic drugs -- Surveys ,Antipsychotic drugs -- Reports ,Antipsychotic drugs -- Genetic aspects ,Gene expression -- Surveys ,Gene expression -- Reports ,Gene expression -- Genetic aspects ,Diabetes -- Prevention ,Diabetes -- Surveys ,Diabetes -- Reports ,Diabetes -- Genetic aspects ,Mice -- Surveys ,Mice -- Reports ,Mice -- Genetic aspects ,Progesterone -- Statistics ,Progesterone -- Surveys ,Progesterone -- Reports ,Progesterone -- Genetic aspects ,Weight reducing preparations -- Surveys ,Weight reducing preparations -- Reports ,Weight reducing preparations -- Genetic aspects ,Bipolar disorder -- Prevention ,Bipolar disorder -- Surveys ,Bipolar disorder -- Reports ,Bipolar disorder -- Genetic aspects ,Depression, Mental -- Prevention ,Depression, Mental -- Surveys ,Depression, Mental -- Reports ,Depression, Mental -- Genetic aspects ,Tumor necrosis factor -- Surveys ,Tumor necrosis factor -- Reports ,Tumor necrosis factor -- Genetic aspects ,Health - Published
- 2003
5. Molecular signaling pathways that link depression and heart disease
- Author
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Finkel, Mitchell S.
- Subjects
Anxiety -- Risk factors ,Anxiety -- Prevention ,Anxiety -- Prognosis ,Anxiety -- Genetic aspects ,Anxiety -- Social aspects ,Inositol -- Genetic aspects ,Inositol -- Social aspects ,Guanosine -- Genetic aspects ,Guanosine -- Social aspects ,Serotonin uptake inhibitors -- Genetic aspects ,Serotonin uptake inhibitors -- Social aspects ,Cardiac patients -- Prognosis ,Cardiac patients -- Genetic aspects ,Cardiac patients -- Social aspects ,Endothelium-derived relaxing factors -- Genetic aspects ,Endothelium-derived relaxing factors -- Social aspects ,Calcium channels -- Genetic aspects ,Calcium channels -- Social aspects ,Smoking -- Risk factors ,Smoking -- Prevention ,Smoking -- Prognosis ,Smoking -- Genetic aspects ,Smoking -- Social aspects ,Tyrosine -- Genetic aspects ,Tyrosine -- Social aspects ,Diabetes -- Risk factors ,Diabetes -- Prevention ,Diabetes -- Prognosis ,Diabetes -- Genetic aspects ,Diabetes -- Social aspects ,Arginine -- Genetic aspects ,Arginine -- Social aspects ,Essential fatty acids -- Genetic aspects ,Essential fatty acids -- Social aspects ,Fibrin -- Genetic aspects ,Fibrin -- Social aspects ,Infection -- Risk factors ,Infection -- Prevention ,Infection -- Prognosis ,Infection -- Genetic aspects ,Infection -- Social aspects ,Protein kinases -- Genetic aspects ,Protein kinases -- Social aspects ,Mitogens -- Genetic aspects ,Mitogens -- Social aspects ,Endothelium -- Genetic aspects ,Endothelium -- Social aspects ,Thrombin -- Genetic aspects ,Thrombin -- Social aspects ,Tumor necrosis factor -- Genetic aspects ,Tumor necrosis factor -- Social aspects ,Hypertension -- Risk factors ,Hypertension -- Prevention ,Hypertension -- Prognosis ,Hypertension -- Genetic aspects ,Hypertension -- Social aspects ,Corticosteroids -- Genetic aspects ,Corticosteroids -- Social aspects ,Congestive heart failure -- Risk factors ,Congestive heart failure -- Prevention ,Congestive heart failure -- Prognosis ,Congestive heart failure -- Genetic aspects ,Congestive heart failure -- Social aspects ,Medical research -- Genetic aspects ,Medical research -- Social aspects ,Medicine, Experimental -- Genetic aspects ,Medicine, Experimental -- Social aspects ,Heart -- Transplantation ,Heart -- Genetic aspects ,Heart -- Social aspects ,Stress (Psychology) -- Risk factors ,Stress (Psychology) -- Prevention ,Stress (Psychology) -- Prognosis ,Stress (Psychology) -- Genetic aspects ,Stress (Psychology) -- Social aspects ,Catecholamines -- Genetic aspects ,Catecholamines -- Social aspects ,Evolutionary biology -- Genetic aspects ,Evolutionary biology -- Social aspects ,Myosin -- Genetic aspects ,Myosin -- Social aspects ,Coronary artery bypass -- Genetic aspects ,Coronary artery bypass -- Social aspects ,Somatostatin -- Genetic aspects ,Somatostatin -- Social aspects ,Nitric oxide -- Genetic aspects ,Nitric oxide -- Social aspects ,Nitrites -- Genetic aspects ,Nitrites -- Social aspects ,Cyclic adenylic acid -- Genetic aspects ,Cyclic adenylic acid -- Social aspects ,Blood vessels -- Dilatation ,Blood vessels -- Genetic aspects ,Blood vessels -- Social aspects ,Nitrogen dioxide -- Genetic aspects ,Nitrogen dioxide -- Social aspects ,Guanylate cyclase -- Genetic aspects ,Guanylate cyclase -- Social aspects ,ACTH -- Genetic aspects ,ACTH -- Social aspects ,Atherosclerosis -- Risk factors ,Atherosclerosis -- Prevention ,Atherosclerosis -- Prognosis ,Atherosclerosis -- Genetic aspects ,Atherosclerosis -- Social aspects ,Phosphatases -- Genetic aspects ,Phosphatases -- Social aspects ,Action potentials (Electrophysiology) -- Genetic aspects ,Action potentials (Electrophysiology) -- Social aspects ,Fibrinogen -- Genetic aspects ,Fibrinogen -- Social aspects ,Glucose metabolism -- Genetic aspects ,Glucose metabolism -- Social aspects ,Proteins -- Genetic aspects ,Proteins -- Social aspects ,Heart diseases -- Risk factors ,Heart diseases -- Prevention ,Heart diseases -- Prognosis ,Heart diseases -- Genetic aspects ,Heart diseases -- Social aspects ,Hormones -- Genetic aspects ,Hormones -- Social aspects ,Health - Published
- 2003
6. Gene Mutations in the Succinate Dehydrogenase Subunit SDHB Cause Susceptibility to Familial Pheochromocytoma and to Familial Paraganglioma
- Author
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Astuti, Dewi, Latif, Farida, Dallol, Ashraf, Dahia, Patricia L. M., Douglas, Fiona, George, Emad, Skoldberg, Filip, Husebye, Eystein S., Eng, Charis, and Maher, Eamonn R.
- Subjects
Gene mutations -- Physiological aspects ,Dehydrogenases -- Genetic aspects ,Pheochromocytoma -- Genetic aspects ,Catecholamines -- Genetic aspects ,Tumors -- Genetic aspects ,Biological sciences - Published
- 2001
7. Fibromyalgia
- Subjects
Anxiety -- Risk factors ,Anxiety -- Care and treatment ,Anxiety -- Analysis ,Anxiety -- Genetic aspects ,Anxiety -- Health aspects ,Practice guidelines (Medicine) -- Analysis ,Practice guidelines (Medicine) -- Genetic aspects ,Practice guidelines (Medicine) -- Health aspects ,Nerve growth factor -- Analysis ,Nerve growth factor -- Genetic aspects ,Nerve growth factor -- Health aspects ,Stress management -- Analysis ,Stress management -- Genetic aspects ,Stress management -- Health aspects ,Rheumatoid factor -- Analysis ,Rheumatoid factor -- Genetic aspects ,Rheumatoid factor -- Health aspects ,Evidence-based medicine -- Analysis ,Evidence-based medicine -- Genetic aspects ,Behavioral health care -- Analysis ,Behavioral health care -- Genetic aspects ,Behavioral health care -- Health aspects ,Sexual abuse -- Analysis ,Sexual abuse -- Genetic aspects ,Sexual abuse -- Health aspects ,Cyclobenzaprine -- Analysis ,Cyclobenzaprine -- Genetic aspects ,Endorphins -- Analysis ,Endorphins -- Genetic aspects ,Insomnia -- Risk factors ,Insomnia -- Care and treatment ,Insomnia -- Analysis ,Insomnia -- Genetic aspects ,Insomnia -- Health aspects ,Fibromyalgia -- Risk factors ,Fibromyalgia -- Care and treatment ,Fibromyalgia -- Analysis ,Fibromyalgia -- Genetic aspects ,Fibromyalgia -- Health aspects ,Arthritis -- Risk factors ,Arthritis -- Care and treatment ,Arthritis -- Analysis ,Arthritis -- Genetic aspects ,Arthritis -- Health aspects ,Acupuncture -- Analysis ,Acupuncture -- Genetic aspects ,Acupuncture -- Health aspects ,Methyl aspartate -- Analysis ,Methyl aspartate -- Genetic aspects ,Methyl aspartate -- Health aspects ,Medicine, Botanic -- Analysis ,Medicine, Botanic -- Genetic aspects ,Medicine, Botanic -- Health aspects ,Medicine, Herbal -- Analysis ,Medicine, Herbal -- Genetic aspects ,Medicine, Herbal -- Health aspects ,Medical research -- Analysis ,Medical research -- Genetic aspects ,Medical research -- Health aspects ,Medicine, Experimental -- Analysis ,Medicine, Experimental -- Genetic aspects ,Medicine, Experimental -- Health aspects ,Chronic diseases -- Risk factors ,Chronic diseases -- Care and treatment ,Chronic diseases -- Analysis ,Chronic diseases -- Genetic aspects ,Chronic diseases -- Health aspects ,Gabapentin -- Analysis ,Gabapentin -- Genetic aspects ,Gabapentin -- Health aspects ,Oxidases -- Analysis ,Oxidases -- Genetic aspects ,Oxidases -- Health aspects ,Tryptophan -- Analysis ,Tryptophan -- Genetic aspects ,Tryptophan -- Health aspects ,Catecholamines -- Analysis ,Catecholamines -- Genetic aspects ,Catecholamines -- Health aspects ,Rocks, Sedimentary -- Analysis ,Rocks, Sedimentary -- Genetic aspects ,Rocks, Sedimentary -- Health aspects ,Sleep apnea syndromes -- Risk factors ,Sleep apnea syndromes -- Care and treatment ,Sleep apnea syndromes -- Analysis ,Sleep apnea syndromes -- Genetic aspects ,Sleep apnea syndromes -- Health aspects ,Epilepsy -- Risk factors ,Epilepsy -- Care and treatment ,Epilepsy -- Analysis ,Epilepsy -- Genetic aspects ,Epilepsy -- Health aspects ,Somatotropin -- Analysis ,Somatotropin -- Genetic aspects ,Somatotropin -- Health aspects ,GABA -- Analysis ,GABA -- Genetic aspects ,GABA -- Health aspects ,Prevalence studies (Epidemiology) -- Analysis ,Prevalence studies (Epidemiology) -- Genetic aspects ,Prevalence studies (Epidemiology) -- Health aspects ,Fluoxetine -- Analysis ,Fluoxetine -- Genetic aspects ,Fluoxetine -- Health aspects ,Excitatory amino acids -- Analysis ,Excitatory amino acids -- Genetic aspects ,Hormones -- Analysis ,Hormones -- Genetic aspects ,Hormones -- Health aspects ,Pain -- Care and treatment ,Pain -- Analysis ,Pain -- Genetic aspects ,Pain -- Health aspects ,Family and marriage ,Health - Abstract
Fibromyalgia Authors: Vani Velkuru, MD, Fellow, Rheumatology, Loma Linda University, Loma Linda, CA ; and Keith Colburn, MD, Professor of Medicine, Chief of Rheumatology, Loma Linda University and Loma Linda [...]
- Published
- 2009
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