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113 results on '"Caterbi, Sara"'

2. Essential oil composition, polar compounds, glandular trichomes and biological activity of Hyssopus officinalis subsp. aristatus (Godr.) Nyman from central Italy

Author

Venditti, Alessandro, Bianco, Armandodoriano, Frezza, Claudio, Conti, Fabio, Bini, Laura Maleci, Giuliani, Claudia, Bramucci, Massimo, Quassinti, Luana, Damiano, Silvia, Lupidi, Giulio, Beghelli, Daniela, Caterbi, Sara, Petrelli, Dezemona, Vitali, Luca A., Papa, Fabrizio, Caprioli, Giovanni, and Maggi, Filippo

Published
2015
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15. Circulating interferon-inducible protein IFI16 correlates with clinical and serological features in rheumatoid arthritis

Author

Alunno, Alessia, Caneparo, Valeria, Bistoni, Onelia, Caterbi, Sara, Terenzi, Riccardo, Gariglio, Marisa, Bartoloni, Elena, Manzo, Antonio, Landolfo, Santo Giuseppe, and Gerli, Roberto

Subjects
Lung Diseases, Male, Nuclear Proteins, Enzyme-Linked Immunosorbent Assay, Middle Aged, Phosphoproteins, Peptides, Cyclic, Up-Regulation, Arthritis, Rheumatoid, Rheumatoid Factor, Case-Control Studies, Osteoarthritis, Synovial Fluid, Humans, Female, Serologic Tests, Biomarkers, Aged, Autoantibodies
Abstract

The interferon-inducible protein 16 (IFI16) has been detected in sera from patients with autoimmune/inflammatory diseases, but not in healthy subjects. This leaking leads to loss of tolerance toward this self-protein and the development of autoantibodies. In this study, clinical significance of both IFI16 protein and anti-IFI16 antibodies in rheumatoid arthritis (RA) was investigated.IFI16 protein and anti-IFI16 antibody levels were assessed by enzyme-linked immunosorbent assay in serum samples from 154 RA patients and 182 healthy controls, and in synovial fluid (SF) samples from 21 RA patients and 25 patients with osteoarthritis (OA).Mean serum levels for both IFI16 and anti-IFI16 antibodies were higher in RA patients than in healthy controls, with a direct correlation between IFI16 concentration and anti-IFI16 antibody titer. The majority of RA patients with detectable circulating IFI16 protein were also positive for rheumatoid factor (RF)/anti-cyclic citrullinated peptide antibody (anti-CCP). The latter group was found to be positive for anti-IFI16 antibodies as well. The mean SF concentrations of both IFI16 protein and anti-IFI16 antibodies were higher in RA patients when compared with control OA patients. Interestingly, the presence of circulating IFI16 protein, but not anti-IFI16 antibodies, significantly correlated with RA-associated pulmonary disease. This correlation was not dependent on the presence of anti-IFI16 antibodies, sex, and smoking habit.Our data demonstrate that the high levels of circulating IFI16 in RA are more frequent in RF/anti-CCP-positive RA patients and significantly associated with pulmonary involvement. The relevance of circulating IFI16 protein as a new clinical biomarker of RA should be verified with additional studies.

Published
2016

17. T Regulatory and T Helper 17 Cells in Primary Sjögren’s Syndrome: Facts and Perspectives

Author

Alunno, Alessia, Carubbi, Francesco, Bistoni, Onelia, Caterbi, Sara, Bartoloni, Elena, Mirabelli, Giulia, Cannarile, Francesca, Cipriani, Paola, Giacomelli, Roberto, and Gerli, Roberto

Subjects
stomatognathic diseases, Article Subject
Abstract

Historically, primary Sjögren’s syndrome (pSS) was thought to be a T helper (h) 1 driven disease due to the predominance of CD4+T lymphocytes and their products in target organs and peripheral blood of patients. In the last decades, the identification of a number of T cell subsets, including Th17, T regulatory (Treg), and follicular helper T cells, challenged this long-standing paradigm and prompted to identify their role in pSS pathogenesis. In addition the impact of abnormal proinflammatory cytokine production, such as IL-6, IL-17, IL-22, and IL-23, has also attracted considerable attention. However, although several studies have been carried out in experimental models and patients with pSS, many aspects concerning the role of Treg cells and IL-17/Th17 cell system in pSS pathogenesis are not fully elucidated. In particular, the role played by different IL-17-producing T cell subsets as well as the effects of pharmacological therapies on Treg/Th17 cell balance represents an intriguing issue. The aim of this review article is to provide an overview of current knowledge on Treg cells and IL-17-producing T cells in pSS pathogenesis. We believe that these insights into pSS pathogenesis may provide the basis for successful therapeutic intervention in this disease.

Published
2015
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18. Altered Immunoregulation in Rheumatoid Arthritis: The Role of Regulatory T Cells and Proinflammatory Th17 Cells and Therapeutic Implications

Author

Alunno, Alessia, Manetti, Mirko, Caterbi, Sara, Ibba-Manneschi, Lidia, Bistoni, Onelia, Bartoloni, Elena, Valentini, Valentina, Terenzi, Riccardo, and Gerli, Roberto

Subjects
Article Subject, chemical and pharmacologic phenomena, hemic and immune systems
Abstract

In recent years several studies investigated the role of T lymphocyte subpopulations in the pathogenesis of rheumatoid arthritis (RA). Pathogenic Th17 cells mediate pannus growth, osteoclastogenesis, and synovial neoangiogenesis; hence they are key players in the development of the disease. On the other hand, regulatory T (Treg) cells are a T cell subset whose peculiar function is to suppress autoreactive lymphocytes. The imbalance between Th17 and Treg cells has been identified as a crucial event in the pathogenesis of RA. In addition, the effects of currently employed RA therapeutic strategies on these lymphocyte subpopulations have been extensively investigated. This review article aims to discuss current knowledge on Treg and Th17 cells in RA and possible implications of their therapeutic targeting in this disorder.

Published
2015
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27. ID: 40

Author

Caneparo, Valeria, primary, Alunno, Alessia, additional, Bistoni, Onelia, additional, Caterbi, Sara, additional, Terenzi, Riccardo, additional, Gariglio, Marisa, additional, Bartoloni, Elena, additional, Gerli, Roberto, additional, and Landolfo, Santo, additional

Published
2015
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29. Erratum to “Is minor salivary gland biopsy more than a diagnostic tool in primary Sjo¨gren’s syndrome? Association between clinical, histopathological, and molecular features: A retrospective study” [Semin Arthritis Rheum 44 (2014) 314–324]

Author

Carubbi, Francesco, primary, Alunno, Alessia, additional, Cipriani, Paola, additional, Di Benedetto, Paola, additional, Ruscitti, Piero, additional, Berardicurti, Onorina, additional, Bartoloni, Elena, additional, Bistoni, Onelia, additional, Caterbi, Sara, additional, Ciccia, Francesco, additional, Triolo, Giovanni, additional, Gerli, Roberto, additional, and Giacomelli, Roberto, additional

Published
2015
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36. In vitro immunomodulatory effects of microencapsulated umbilical cord Wharton jelly-derived mesenchymal stem cells in primary Sjögren’s syndrome

Author

Alunno, Alessia, primary, Montanucci, Pia, additional, Bistoni, Onelia, additional, Basta, Giuseppe, additional, Caterbi, Sara, additional, Pescara, Teresa, additional, Pennoni, Ilaria, additional, Bini, Vittorio, additional, Bartoloni, Elena, additional, Gerli, Roberto, additional, and Calafiore, Riccardo, additional

Published
2014
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37. A6.2 Purified microbial capsular polysaccharide Galactoxylomannan (GalXM) inhibits the effector T lymphocyte arm and potentiates the regulatory counterpart in rheumatoid arthritis

Author

Alunno, Alessia, primary, Pericolini, Eva, additional, Gabrielli, Elena, additional, Bistoni, Onelia, additional, Caterbi, Sara, additional, Bartoloni, Elena, additional, Terenzi, Riccardo, additional, Valentini, Eleonora, additional, La Paglia, Giuliana, additional, Chow, Siu-Kei, additional, Casadevall, Arturo, additional, Vecchiarelli, Anna, additional, and Gerli, Roberto, additional

Published
2014
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38. A3.8 Association between clinical, histopathological and molecular features in primary Sjögren’s Syndrome: a retrospective study

Author

Carubbi, Francesco, primary, Alunno, Alessia, additional, Cipriani, Paola, additional, Di Benedetto, Paola, additional, Ruscitti, Piero, additional, Berardicurti, Onorina, additional, Bistoni, Onelia, additional, Caterbi, Sara, additional, Bartoloni, Elena, additional, Gerli, Roberto, additional, and Giacomelli, Roberto, additional

Published
2014
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39. A3.1 Pathogenic role of IL-17 producing double negative (DN) T cells in primary sjögren’s syndrome

Author

Alunno, Alessia, primary, Carubbi, Francesco, additional, Bistoni, Onelia, additional, Caterbi, Sara, additional, Bartoloni, Elena, additional, Santoboni, Gianluca, additional, Mirabelli, Giulia, additional, Cannarile, Francesca, additional, Valentini, Valentina, additional, Cipriani, Paola, additional, Giacomelli, Roberto, additional, and Gerli, Roberto, additional

Published
2014
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42. IL-17-producing CD4−CD8−T cells are expanded in the peripheral blood, infiltrate salivary glands and are resistant to corticosteroids in patients with primary Sjögren's syndrome

Author

Alunno, Alessia, primary, Bistoni, Onelia, additional, Bartoloni, Elena, additional, Caterbi, Sara, additional, Bigerna, Barbara, additional, Tabarrini, Alessia, additional, Mannucci, Roberta, additional, Falini, Brunangelo, additional, and Gerli, Roberto, additional

Published
2012
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47. IL-17-producing CD4- CD8- T cells are expanded in the peripheral blood, infiltrate salivary glands and are resistant to corticosteroids in patients with primary Sjögren's syndrome.

Author

Alunno, Alessia, Bistoni, Onelia, Bartoloni, Elena, Caterbi, Sara, Bigerna, Barbara, Tabarrini, Alessia, Mannucci, Roberta, Falini, Brunangelo, and Gerli, Roberto

Abstract

Objectives It has been recently observed that a T-cell subset, lacking of both CD4 and CD8 molecules and defined as double negative (DN), is expanded in the blood of patients with systemic lupus erythematosus, produces IL-17 and accumulates in the kidney during nephritis. Since IL-17 production is enhanced in salivary gland infiltrates of primary Sjögren's syndrome (SS) patients, we investigated whether DN T cells may be involved in the pathogenesis of salivary gland damage. Methods Phenotypic characterisation of peripheral blood mononuclear cells from SS patients and controls was performed by flow cytometry in freshly isolated and anti-CD3-stimulated cells. SS minor salivary glands were processed for immunofluorescence staining. Results CD3+ CD4- CD8- DN T cells were major producers of IL-17 in SS and expressed ROR-γt. They were expanded in the peripheral blood, spontaneously produced IL-17 and infiltrated salivary glands. In addition, the expansion of αβ-TCR+ DN T cells was associated with disease activity. Notably, IL-17-producing DN T cells from SS patients, but not from healthy controls, were strongly resistant to the in vitro effect of dexamethasone. Conclusions These findings appear to be of great interest since the identification of a peculiar T-cell subset with pro-inflammatory activity, but resistant to corticosteroids, in an autoimmune disorder such as SS may help to design new specific treatments for the disease. [ABSTRACT FROM AUTHOR]

Published
2013
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48. Expansion of regulatory GITR+CD25low/-CD4+T cells in systemic lupus erythematosus patients

Author

Nocentini, Giuseppe, Alunno, Alessia, Petrillo, Maria, Bistoni, Onelia, Bartoloni, Elena, Caterbi, Sara, Ronchetti, Simona, Migliorati, Graziella, Riccardi, Carlo, and Gerli, Roberto

Abstract

CD4+CD25low/-GITR+T lymphocytes expressing forkhead box protein P3(FoxP3) and showing regulatory activity have been recently described in healthy donors. The objective of the study was to evaluate the proportion of CD4+CD25low/-GITR+T lymphocytes within CD4+T cells and compare their phenotypic and functional profile with that of CD4+CD25highGITR−T lymphocytes in systemic lupus erythematosus (SLE) patients. The percentage of CD4+CD25low/-GITR+cells circulating in the peripheral blood (PB) of 32 patients with SLE and 25 healthy controls was evaluated with flow cytometry. CD4+CD25low/-GITR+cells were isolated with magnetic separation, and their phenotype was compared with that of CD4+CD25highGITR−cells. Regulatory activity of both cell subsets was tested in autologous and heterologous co-cultures after purification through a negative sorting strategy. Results indicated that CD4+CD25low/-GITR+cells are expanded in the PB of 50% of SLE patients. Expansion was observed only in patients with inactive disease. Phenotypic analysis demonstrated that CD4+CD25low/-GITR+cells display regulatory T-cell (Treg) markers, including FoxP3, cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), transforming growth factor-beta (TGF-β), and interleukin (IL)-10. In contrast, CD4+CD25highGITR−cells appear to be activated and express low levels of Treg markers. Functional experiments demonstrated that CD4+CD25low/-GITR+cells exert a higher inhibitory activity against both autologous and heterologous cells as compared with CD4+CD25highGITR−cells. Suppression is independent of cell contact and is mediated by IL-10 and TGF-β. Phenotypic and functional data demonstrate that in SLE patients, CD4+CD25low/-GITR+cells are fully active Treg cells, possibly representing peripheral Treg (pTreg) that are expanded in patients with inactive disease. These data may suggest a key role of this T-cell subset in the modulation of the abnormal immune response in SLE. Strategies aimed at expanding this Treg subset for therapeutic purpose deserve to be investigated.

Published
2014
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49. Plasmepsin 4-Deficient Plasmodium bergheiAre Virulence Attenuated and Induce Protective Immunity against Experimental Malaria

Author

Spaccapelo, Roberta, Janse, Chris J., Caterbi, Sara, Franke-Fayard, Blandine, Bonilla, J. Alfredo, Syphard, Luke M., Di Cristina, Manlio, Dottorini, Tania, Savarino, Andrea, Cassone, Antonio, Bistoni, Francesco, Waters, Andrew P., Dame, John B., and Crisanti, Andrea

Abstract

Plasmodiumparasites lacking plasmepsin 4 (PM4), an aspartic protease that functions in the lysosomal compartment and contributes to hemoglobin digestion, have only a modest decrease in the asexual blood-stage growth rate; however, PM4 deficiency in the rodent malaria parasite Plasmodium bergheiresults in significantly less virulence than that for the parental parasite. P. berghei Δpm4parasites failed to induce experimental cerebral malaria (ECM) in ECM-susceptible mice, and ECM-resistant mice were able to clear infections. Furthermore, after a single infection, all convalescent mice were protected against subsequent parasite challenge for at least 1 year. Real-time in vivoparasite imaging and splenectomy experiments demonstrated that protective immunity acted through antibody-mediated parasite clearance in the spleen. This work demonstrates, for the first time, that a single Plasmodiumgene disruption can generate virulence-attenuated parasites that do not induce cerebral complications and, moreover, are able to stimulate strong protective immunity against subsequent challenge with wild-type parasites. Parasite blood-stage attenuation should help identify protective immune responses against malaria, unravel parasite-derived factors involved in malarial pathologies, such as cerebral malaria, and potentially pave the way for blood-stage whole organism vaccines.

Published
2010
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50. CD4−CD8− T-cells in primary Sjögren's syndrome: Association with the extent of glandular involvement.

Author

Alunno, Alessia, Carubbi, Francesco, Bistoni, Onelia, Caterbi, Sara, Bartoloni, Elena, Bigerna, Barbara, Pacini, Roberta, Beghelli, Daniela, Cipriani, Paola, Giacomelli, Roberto, and Gerli, Roberto

Subjects
*SJOGREN'S syndrome, *CD4 antigen, *T cells, *INTERLEUKIN-17, *AUTOIMMUNE diseases, *SALIVARY glands
Abstract

Abstract: Objectives: Growing evidence suggests that IL-17-producing T cells, lacking both CD4 and CD8 molecules and defined as double negative (DN) cells, play a pivotal role in the pathogenesis of a number of systemic autoimmune disorders. We recently demonstrated that this T-cell subset is expanded in the peripheral blood (PB) of patients with primary Sjögren's syndrome (pSS), produces IL-17 and accumulates in minor salivary glands (MSGs). We aimed to investigate glandular and PB DN T cells in early pSS in order to verify a possible correlation with MSGs histological patterns and clinical parameters. Methods: Paired samples of PB mononuclear cells and MSGs from pSS patients were evaluated at the diagnosis by flow cytometry and immunofluorescence staining respectively. Histological analysis to identify histological scores, B/T cell segregation and the presence of germinal center (GC)-like structures was also performed. Results: In early stages of pSS, circulating DN T cells appear to be not yet expanded and inversely correlated with circulating CD4+Th17 cells. The number of infiltrating DN T cells were associated with extent of glandular involvement, presence of GC-like structures and dryness symptoms and were inversely correlated with circulating DN T cells. Conclusions: Our findings suggest that DN T cells are actively involved in the pathogenic mechanisms leading to glandular dysfunction and damage in pSS and may play a role in ectopic lymphoneogenesis development occurring during the disease. [Copyright &y& Elsevier]

Published
2014
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