1. Prevalence of hepatitis D virus infection in Central Italy has remained stable across the last 2 decades with dominance of subgenotypes 1 and characterized by elevated viral replication
- Author
-
Romina Salpini, Lorenzo Piermatteo, Giulia Torre, Stefano D'Anna, Sohaib Khan, Leonardo Duca, Ada Bertoli, Simone La Frazia, Vincenzo Malagnino, Elisabetta Teti, Marco Iannetta, Pierpaolo Paba, Marco Ciotti, Ilaria Lenci, Simona Francioso, Caterina Paquazzi, Miriam Lichtner, Claudio Mastroianni, Francesco Santopaolo, Giuseppe De Sanctis, Adriano Pellicelli, Giovanni Galati, Alessandra Moretti, Katia Casinelli, Luciano Caterini, Nerio Iapadre, Giustino Parruti, Iacopo Vecchiet, Maurizio Paoloni, Massimo Marignani, Francesca Ceccherini-Silberstein, Leonardo Baiocchi, Sandro Grelli, Loredana Sarmati, and Valentina Svicher
- Subjects
Hepatitis D virus ,Hepatitis B virus ,HDV prevalence ,HDV-RNA quantification ,HDV chronic infection ,Infectious and parasitic diseases ,RC109-216 - Abstract
Objectives: Here we investigate Hepatitis D virus (HDV)-prevalence in Italy and its fluctuations over time and we provide an extensive characterization of HDV-infected patients. Methods: The rate of HDV seroprevalence and HDV chronicity was assessed in 1579 hepatitis B surface antigen (HBsAg)+ patients collected from 2005 to 2022 in Central Italy. Results: In total, 45.3% of HBsAg+ patients received HDV screening with an increasing temporal trend: 15.6% (2005-2010), 45.0% (2011-2014), 49.4% (2015-2018), 71.8% (2019-2022). By multivariable model, factors correlated with the lack of HDV screening were alanine-aminotransferase (ALT) less than two times of upper limit of normality (
- Published
- 2024
- Full Text
- View/download PDF