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1. Synthetic approaches to asymmetric phthalocyanines and their analogues

Author: Victor N. Nemykin, Semyon V. Dudkin, Fabienne Dumoulin, Catherine Hirel, Ayşe Gül Gürek, and Vefa Ahsen
Subjects: Organic chemistry, QD241-441
Published: 2014
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2. Mechanism of the Zn(II)Phthalocyanines’ Photochemical Reactions Depending on the Number of Substituents and Geometry

Author: Leandro Henrique Zucolotto Cocca, Mehmet Menaf Ayhan, Ayşe Gül Gürek, Vefa Ahsen, Yann Bretonnière, Jonathas de Paula Siqueira, Fernando Gotardo, Cleber Renato Mendonça, Catherine Hirel, and Leonardo De Boni
Subjects: Zn(II)phthalocyanine, optical nonlinearities, luminescence, Organic chemistry, QD241-441
Abstract: In this work, the synthesis and the nonlinear absorption and population dynamics investigation of a series of zinc phthalocyanines (ZnPcs) dissolved in chloroform are reported. In order to determine the relevant spectroscopic parameters, such as absorption cross-sections of singlet and triplet excited states, fluorescence relaxation times, intersystem crossing, radiative decay and internal conversion, different optical and spectroscopic techniques were used. By single pulse and pulse train Z-scan techniques, respectively, singlet and triplet excited states‘ absorption cross-section were determined at 532 nm. Furthermore, the intersystem crossing time was obtained by using both techniques combined with the fluorescence lifetime determined by time-resolved fluorescence. The radiative and internal conversion rates were determined from the fluorescence quantum yield of the samples. Such spectroscopy parameters are fundamental for selecting photosensitizers used in photodynamic therapy, as well as for many other applications.
Published: 2016
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3. Intracranial Hemorrhage in the TST Trial

Author: Pierre Amarenco, Jong S. Kim, Julien Labreuche, Hugo Charles, Maurice Giroud, Philippa C. Lavallée, Byung-Chul Lee, Marie-Hélène Mahagne, Elena Meseguer, Norbert Nighoghossian, Philippe Gabriel Steg, Éric Vicaut, Eric Bruckert, Pierre-Jean Touboul, Didier Leys, Yannick Béjot, Fernando Pico, Emmanuel Touzé, Gregory Ducrocq, Jérémy Abtan, Olivier Varenne, Agnes Kemmel, Fausta Syana, Manele Ledra, Tharani Nagasara, Mervette Ledjeroud, Bahous Samia, Hafirassou Hadia, Benyoub Hazare, Ikrame El Jaghouni, Nessima Yelles, Sofia Zemouri, Mervette Ladjeroud, Salim Kerai, YunJeong In, Cristina Hobeanu, Celine Guidoux, Lucie Cabrejo, Bertrand Lapergue, Candice Sabben, Jaime Gonzalez-Valcarcel, Ricardo Rigual, Gaia Sirimarco, Anna Martin-Bechet, Elena Viedma, Ioan Avram, Yves Samson, Charlotte Rosso, Sophie Crozier, Sara Leder, Anne Léger, Sandrine Deltour, Gurkan Mutlu, Marion Yger, Chiara Zavanone, Flore Baronnet, Christine Pires, Adrien Wang, Serge Evrard, Maya Tchikviladze, Frédéric Bourdain, Delphine Lopez, Laetitia Bayon de la Tour, Marie-Laure Chadenat, Duc Long Duong, Solène Genty, Catherine Hirel, Chantal Nifle, Jérôme Servan, Daniela Stanciu, Veronica Sudacevschi, Mélissa Tir, Anne-Cécile Troussière, Jennifer Yeung, Anne-Céline Zeghoudi, Ikram Tidafi-Bayou, Sylvain Lachaud, Tae-Hee Cho, Laura Mechtouff, Thomas Ritzenthaller, Laurent Derex, Carlo Albanesi, Elodie Ong, Amandine Benoit, Nadia Berhoune, Sandra Felix, Maud Esteban-Mader, Igor Sibon, Annabelle Kazadi, François Rouanet, Pauline Renou, Sabrina Debruxelles, Mathilde Poli, Sharmila Sagnier, Jean-Louis Mas, Valérie Domigo, Catherine Lamy, Eric Bodiguel, Jérôme Grimaud, Valentin Bohotin, Michael Obadia, Erwan Morvan, Gilles Rodier, Wilfried Vadot, Hilde Hénon, Charlotte Cordonnier, Frédéric Dumont, Marie Bodenant, Christian Lucas, Solène Moulin, Nelly Dequatre, Sonia Alamowitch, Jean-Paul Muresan, Thomas Drouet, Magalie Gallea, Marie-Amélie Dalloz, Stephen Delorme, Philippe Loisel, Carine Bonnin, Virginie Bernigal, Guy Victor Osseby, Marie Hervieu-BègueMarsac, Pierre Garnier, Sandrine Accassat, Magali Epinat, Jérôme Varvat, Doïna Marinescu, Aude Triquenot-Bagan, Ozlem Ozkul- Wermester, Frédéric Philippeau, Anne Vieillart, Annie Lannuzel, Alice Demoly, Valérie Wolff, Mihaela Diaconu, Marc Bataillard, Francisco Macian Montoro, Frédéric Faugeras, Laeticia Gimenez, Françoise Abdallah-Lebeau, Serge Timsit, Irina Viakhireva-Dovganyuk, Anne Tirel-Badets, François-Mathias Merrien, Philippe Goas, François Rouhart, Aurore Jourdain, Benoit Guillon, Fanny Hérissson, Mathieu Sevin-Allouet, Nathalie Nasr, Jean-Marc Olivot, Alderic Lecluse, Guillaume Marc, null Hamon, Vincent de la Sayette, Marion Apoil, Li Lin, Julien Cogez, Sophie Guettier, Olivier Godefroy, Chantal Lamy, Jean-Marc Bugnicourt, Grégory Taurin, Marc Mérienne, Julien Gere, Anne-Marie Chessak, Tarik Habet, Anna Ferrier, Nathalie Bourgois, Dominique Minier, Marie Caillier-Minier, Fabienne Contégal- Callier, Philippe Vion, Yvan Vaschalde, Mohammed El Amrani, null Emilie, Mathieu Zuber, Marie Bruandet, Claire Join- Lambert, Pierre-Yves Garcia, Isabelle Serre, Jean-Marc Faucheux, Fatia Radji, Elena Leca-Radu, Thomas Debroucker, Rodica Cumurcuc, Serkan Cakmak, Stéphane Peysson, Emmanuel Ellie, Patricia Bernady, Thierry Moulin, Paola Montiel, Eugeniu Revenco, Pierre Decavel, Elisabeth Medeiros, Myriam Bouveret, Pierre Louchart, Claudia Vaduva, Grégory Couvreur, Eric Sartori, null Alnajar-Carpentier, Michèle Levasseur, Jean-Philippe Neau, Xavier Vandamme, Isabelle Meresse, null Stantescu, Canan Ozsancak, Katell Beauvais, Pascal Auzou, Joséphine Amevigbe, Francis Vuillemet, Marie-Hélène Dugay-Arentz, Gabriela Carelli, Mikel Martinez, Marcel Maillet-Vioud, Jean-Pierre Escaillas, Stéphane Chapuis, Jean Tardy, Eric Manchon, Olivier Varnet, Yong-Jae Kim, Yoonkyung Chang, Tae-Jin Song, Jong Sung Kim, Jung-Hoon Han, Kyung Chul Noh, Eun-Jae Lee, Dong-Wha Kang, Sun Uck Kwon, Boseoung Kwon, Seongho Park, Dongwhane Lee, Hyuk Sung Kwon, Daeun Jeong, MinHwan Lee, Joonggoo Kim, Hanbin Lee, Hyo Jung Nam, Sang Hun Lee, Bum Joon Kim, Jae-kwan Cha, DaeHyun Kim, Rae Young Kim, Sang Wuk Sohn, Dong-Hyun Shim, Hyungjin Lee, Hyun-Wook Nah, Sang Min Sung, Kyung Bok Lee, Jeong Yoon Lee, Jee Eun Yoon, Eung-Gyu Kim, Jung Hwa Seo, Yong-Won Kim, Yangha Hwang, Man Seok Park, Joon-Tae Kim, Kang-Ho Choi, Hyo Suk Nam, Ji Hoe Heo, Young Dae Kim, In Gun Hwang, Hyung Jong Park, Kyoung Sub Kim, Jang Hyun Baek, Dong Beom Song, Joon Sang Yoo, Jong-Moo Park, Ohyun Kwon, Woong-Woo Lee, Jung-Ju Lee, Kyusik Kang, Byung Kun Kim, Jae-Sung Lim, Mi Sun Oh, Kyung-Ho Yu, Bora Hong, Mihoon Jang, Seyoung Jang, Jung Eun Jin, Jei Kim, Hye Seon Jeong, Keun Sik Hong, Hong Kyun Park, Yong Jin Cho, Oh Young Bang, Keun Seo, Jongwon Chung, Laboratoire de Recherche Vasculaire Translationnelle (LVTS (UMR_S_1148 / U1148)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Asan Medical Center [Seoul, South Korea] (AMC), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Evaluation des technologies de santé et des pratiques médicales - ULR 2694 (METRICS), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Physiopathologie et épidémiologie cérébro-cardiovasculaire [Dijon] (PEC2), Université de Bourgogne (UB)-Université Bourgogne Franche-Comté [COMUE] (UBFC), CHU Dijon, Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Equipe Avenir. University of Burgundy, Hallym University Sacred Heart Hospital [Anyang, South Korea] (HUS2H), Hôpital Pasteur [Nice] (CHU), Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Hospices Civils de Lyon (HCL), Hôpital Lariboisière-Fernand-Widal [APHP], Université Paris Diderot - Paris 7 (UPD7), Université Sorbonne Paris Cité (USPC), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Sorbonne Université (SU), Laboratoire de Neurosciences Fonctionnelles et Pathologies - UR UPJV 4559 (LNFP), Université de Picardie Jules Verne (UPJV), CHU Amiens-Picardie, Treat Stroke to Target Investigators*: Pierre-Jean Touboul, Didier Leys, Yannick Béjot, Fernando Pico, Emmanuel Touzé, Gregory Ducrocq, Jérémy Abtan, Olivier Varenne, Pierre-Jean Touboul, Agnes Kemmel, Fausta Syana, Manele Ledra, Tharani Nagasara, Mervette Ledjeroud, Bahous Samia, Hafirassou Hadia, Benyoub Hazare, Ikrame El Jaghouni, Nessima Yelles, Sofia Zemouri, Mervette Ladjeroud, Salim Kerai, YunJeong In, Cristina Hobeanu, Celine Guidoux, Lucie Cabrejo, Bertrand Lapergue, Candice Sabben, Jaime Gonzalez-Valcarcel, Ricardo Rigual, Gaia Sirimarco, Anna Martin-Bechet, Elena Viedma, Ioan Avram, Yves Samson, Charlotte Rosso, Sophie Crozier, Sara Leder, Anne Léger, Sandrine Deltour, Gurkan Mutlu, Marion Yger, Chiara Zavanone, Flore Baronnet, Christine Pires, Bertrand Lapergue, Adrien Wang, Serge Evrard, Maya Tchikviladze, Frédéric Bourdain, Delphine Lopez, Fernando Pico, Laetitia Bayon de la Tour, Marie-Laure Chadenat, Duc Long Duong, Solène Genty, Catherine Hirel, Gurkan Mutlu, Chantal Nifle, Jérôme Servan, Daniela Stanciu, Veronica Sudacevschi, Mélissa Tir, Anne-Cécile Troussière, Jennifer Yeung, Anne-Céline Zeghoudi, Ikram Tidafi-Bayou, Sylvain Lachaud, Tae-Hee Cho, Laura Mechtouff, Thomas Ritzenthaller, Laurent Derex, Carlo Albanesi, Elodie Ong, Amandine Benoit, Nadia Berhoune, Sandra Felix, Maud Esteban-Mader, Igor Sibon, Annabelle Kazadi, François Rouanet, Pauline Renou, Sabrina Debruxelles, Mathilde Poli, Sharmila Sagnier, Jean-Louis Mas, Valérie Domigo, Catherine Lamy, Eric Bodiguel, Jérôme Grimaud, Valentin Bohotin, Michael Obadia, Candice Sabben, Erwan Morvan, Gilles Rodier, Wilfried Vadot, Hilde Hénon, Charlotte Cordonnier, Frédéric Dumont, Marie Bodenant, Christian Lucas, Solène Moulin, Nelly Dequatre, Sonia Alamowitch, Jean-Paul Muresan, Thomas Drouet, Magalie Gallea, Marie-Amélie Dalloz, Stephen Delorme, Marion Yger, Yannick Béjot, Philippe Loisel, Carine Bonnin, Virginie Bernigal, Guy Victor Osseby, Marie Hervieu-BègueMarsac, Pierre Garnier, Sandrine Accassat, Magali Epinat, Jérôme Varvat, Doïna Marinescu, Aude Triquenot-Bagan, Ozlem Ozkul-Wermester, Frédéric Philippeau, Anne Vieillart, Annie Lannuzel, Alice Demoly, Valérie Wolff, Mihaela Diaconu, Marc Bataillard, Francisco Macian Montoro, Frédéric Faugeras, Laeticia Gimenez, Françoise Abdallah-Lebeau, Serge Timsit, Irina Viakhireva-Dovganyuk, Anne Tirel-Badets, François-Mathias Merrien, Philippe Goas, François Rouhart, Aurore Jourdain, Benoit Guillon, Fanny Hérissson, Mathieu Sevin-Allouet, Nathalie Nasr, Jean-Marc Olivot, Alderic Lecluse, Guillaume Marc, Hamon, Emmanuel Touzé, Vincent de la Sayette, Marion Apoil, Li Lin, Julien Cogez, Sophie Guettier, Olivier Godefroy, Chantal Lamy, Jean-Marc Bugnicourt, Grégory Taurin, Marc Mérienne, Julien Gere, Anne-Marie Chessak, Tarik Habet, Anna Ferrier, Nathalie Bourgois, Dominique Minier, Marie Caillier-Minier, Fabienne Contégal-Callier, Philippe Vion, Yvan Vaschalde, Mohammed El Amrani, Emilie, Mathieu Zuber, Marie Bruandet, Claire Join-Lambert, Pierre-Yves Garcia, Isabelle Serre, Jean-Marc Faucheux, Fatia Radji, Elena Leca-Radu, Thomas Debroucker, Rodica Cumurcuc, Serkan Cakmak, Stéphane Peysson, Emmanuel Ellie, Patricia Bernady, Thierry Moulin, Paola Montiel, Eugeniu Revenco, Pierre Decavel, Elisabeth Medeiros, Myriam Bouveret, Pierre Louchart, Claudia Vaduva, Grégory Couvreur, Eric Sartori, Alnajar-Carpentier, Michèle Levasseur, Pierre Louchart, Jean-Philippe Neau, Xavier Vandamme, Isabelle Meresse, Stantescu, Marc Bataillard, Canan Ozsancak, Katell Beauvais, Pascal Auzou, Joséphine Amevigbe, Francis Vuillemet, Marie-Hélène Dugay-Arentz, Gabriela Carelli, Mikel Martinez, Marcel Maillet-Vioud, Jean-Pierre Escaillas, Stéphane Chapuis, Jean Tardy, Eric Manchon, Olivier Varnet, Yong-Jae Kim, Yoonkyung Chang, Tae-Jin Song, Jong Sung Kim, Jung-Hoon Han, Kyung Chul Noh, Eun-Jae Lee, Dong-Wha Kang, Sun Uck Kwon, Boseoung Kwon, Seongho Park, Dongwhane Lee, Hyuk Sung Kwon, Daeun Jeong, MinHwan Lee, Joonggoo Kim, Hanbin Lee, Hyo Jung Nam, Sang Hun Lee, Bum Joon Kim, Jae-Kwan Cha, DaeHyun Kim, Rae Young Kim, Sang Wuk Sohn, Dong-Hyun Shim, Hyungjin Lee, Hyun-Wook Nah, Sang Min Sung, Kyung Bok Lee, Jeong Yoon Lee, Jee Eun Yoon, Eung-Gyu Kim, Jung Hwa Seo, Yong-Won Kim, Yangha Hwang, Man Seok Park, Joon-Tae Kim, Kang-Ho Choi, Hyo Suk Nam, Ji Hoe Heo, Young Dae Kim, In Gun Hwang, Hyung Jong Park, Kyoung Sub Kim, Jang Hyun Baek, Dong Beom Song, Joon Sang Yoo, Jong-Moo Park, Ohyun Kwon, Woong-Woo Lee, Jung-Ju Lee, Kyusik Kang, Byung Kun Kim, Jae-Sung Lim, Mi Sun Oh, Kyung-Ho Yu, Bora Hong, Mihoon Jang, Seyoung Jang, Jung Eun Jin, Jei Kim, Hye Seon Jeong, Keun Sik Hong, Hong Kyun Park, Yong Jin Cho, Oh Young Bang, Keun Seo, Jongwon Chung, and CarMeN, laboratoire
Subjects: Adult, Male, [SDV]Life Sciences [q-bio], Coronary Artery Disease, LDL, Young Adult, Predictive Value of Tests, Risk Factors, Secondary Prevention, Humans, cardiovascular diseases, Aged, Ischemic Stroke, Advanced and Specialized Nursing, Aged, 80 and over, Anticholesteremic Agents, Incidence, cholesterol, Anticoagulants, Cholesterol, LDL, Middle Aged, Ezetimibe, Intracranial Arteriosclerosis, [SDV] Life Sciences [q-bio], Ischemic Attack, Transient, Hypertension, Female, Neurology (clinical), atherosclerosis, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Cardiology and Cardiovascular Medicine, Intracranial Hemorrhages
Abstract: Background and Purpose: Although statins are effective in secondary prevention of ischemic stroke, they are also associated with an increase risk of intracranial hemorrhage (ICH) in certain conditions. In the TST trial (Treat Stroke to Target), we prespecified an exploration of the predictors of incident ICH. Methods: Patients with ischemic stroke in the previous 3 months or transient ischemic attack within the previous 15 days and evidence of cerebrovascular or coronary artery atherosclerosis were randomly assigned in a 1:1 ratio to a target LDL (low-density lipoprotein) cholesterol of Results: Among 2860 patients enrolled, 31 incident ICH occurred over a median follow-up of 3 years (18 and 13 in the lower and higher target group, 3.21/1000 patient-years [95% CI, 2.38–4.04] and 2.32/1000 patient-years [95% CI, 1.61–3.03], respectively). While there were no baseline predictors of ICH, uncontrolled hypertension (HR, 2.51 [95% CI, 1.01–6.31], P =0.041) and being on anticoagulant (HR, 2.36 [95% CI, 1.00–5.62], P =0.047)] during the trial were significant predictors. On-treatment low LDL cholesterol was not a predictor of ICH. Conclusions: Targeting an LDL cholesterol of Registration: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT01252875; EUDRACT identifier: 2009-A01280-57.
Published: 2021
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4. Investigating Musical Emotions in People with Unilateral Brain Damage

Author: Barbara Tillmann, Amy M. Belfi, Daniel Tranel, Anne Caclin, Agathe Pralus, and Catherine Hirel
Subjects: medicine, Brain damage, Musical, medicine.symptom, Psychology, human activities, behavioral disciplines and activities, humanities, Cognitive psychology
Abstract: The study under discussion sought to investigate the hemispheric laterality of musical emotions: Is one hemisphere of the brain preferentially involved in recognizing emotions in music? The authors took a neuropsychological approach to answer this question by studying emotional judgments of music in people with brain damage to either hemisphere. Their results indicated that individuals with left hemisphere damage were significantly impaired in recognizing musical emotions as compared to healthy comparison participants. In contrast, individuals with right hemisphere damage were not impaired at identifying emotions in music, but rated the perceived intensity of the emotions lower for sadness and fear (as compared to joy and serenity). Their work suggests that the identification of emotions in music and the perceived intensity of the emotions expressed may rely on different hemispheres of the brain.
Published: 2022
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5. Benefit of Targeting a LDL (Low-Density Lipoprotein) Cholesterol \textless70 mg/dL During 5 Years After Ischemic Stroke

Author: Pierre Amarenco, Jong S. Kim, Julien Labreuche, Hugo Charles, Maurice Giroud, Byung-Chul Lee, Marie-Hélène Mahagne, Norbert Nighoghossian, Philippe Gabriel Steg, Éric Vicaut, Eric Bruckert, Pierre-Jean Touboul, Didier Leys, Yannick Béjot, Philippa Lavallée, Fernando Pico, Emmanuel Touzé, Gregory Ducrocq, Jérémy Abtan, Olivier Varenne, Agnes Kemmel, Fausta Syana, Manele Ledra, Tharani Nagasara, Mervette Ledjeroud, Bahous Samia, Hafirassou Hadia, Benyoub Hazare, Ikrame El Jaghouni, Nessima Yelles, Sofia Zemouri, Mervette Ladjeroud, Salim Kerai, Yun Jeong In, Elena Meseguer, Philippa C Lavallée, Cristina Hobeanu, Celine Guidoux, Lucie Cabrejo, Bertrand Lapergue, Candice Sabben, Jaime Gonzalez-Valcarcel, Ricardo Rigual, Gaia Sirimarco, Anna Martin-Bechet, Elena Viedma, Ioan Avram, Yves Samson, Charlotte Rosso, Sophie Crozier, Sara Leder, Anne Léger, Sandrine Deltour, Gurkan Mutlu, Marion Yger, Chiara Zavanone, Flore Baronnet, Christine Pires, Adrien Wang, Serge Evrard, Maya Tchikviladze, Frédéric Bourdain, Delphine Lopez, Laetitia Bayon de la Tour, Marie-Laure Chadenat, Duc Long Duong, Solène Genty, Catherine Hirel, Chantal Nifle, Jérôme Servan, Daniela Stanciu, Veronica Sudacevschi, Mélissa Tir, Anne-Cécile Troussière, Jennifer Yeung, Anne-Céline Zeghoudi, Ikram Tidafi-Bayou, Sylvain Lachaud, Tae-Hee Cho, Laura Mechtouff, Thomas Ritzenthaller, Laurent Derex, Carlo Albanesi, Elodie Ong, Amandine Benoit, Nadia Berhoune, Sandra Felix, Maud Esteban-Mader, Igor Sibon, Annabelle Kazadi, François Rouanet, Pauline Renou, Sabrina Debruxelles, Mathilde Poli, Sharmila Sagnier, Jean-Louis Mas, Valérie Domigo, Catherine Lamy, Eric Bodiguel, Jérôme Grimaud, Valentin Bohotin, Michael Obadia, Erwan Morvan, Gilles Rodier, Wilfried Vadot, Hilde Hénon, Charlotte Cordonnier, Frédéric Dumont, Marie Bodenant, Christian Lucas, Solène Moulin, Nelly Dequatre, Sonia Alamowitch, Jean-Paul Muresan, Thomas Drouet, Magalie Gallea, Marie-Amélie Dalloz, Stephen Delorme, Philippe Loisel, Carine Bonnin, Virginie Bernigal, Guy Victor Osseby, Marie Hervieu-Bègue Marsac, Pierre Garnier, Sandrine Accassat, Magali Epinat, Jérôme Varvat, Doïna Marinescu, Aude Triquenot-Bagan, Ozlem Ozkul-Wermester, Frédéric Philippeau, Angel Olaru, Anne Vieillart, Annie Lannuzel, Alice Demoly, Valérie Wolff, Mihaela Diaconu, Marc Bataillard, Francisco Macian Montoro, Frédéric Faugeras, Laeticia Gimenez, Françoise Abdallah-Lebeau, Serge Timsit, Irina Viakhireva-Dovganyuk, Anne Tirel-Badets, François-Mathias Merrien, Philippe Goas, François Rouhart, Aurore Jourdain, Benoit Guillon, Fanny Hérissson, Mathieu Sevin-Allouet, Nathalie Nasr, Jean-Marc Olivot, Alderic Lecluse, Guillaume Marc, Vincent de la Sayette, Marion Apoil, Li Lin, Julien Cogez, Sophie Guettier, Olivier Godefroy, Chantal Lamy, Jean-Marc Bugnicourt, Grégory Taurin, Marc Mérienne, Julien Gere, Anne-Marie Chessak, Tarik Habet, Anna Ferrier, Nathalie Bourgois, Dominique Minier, Marie Caillier-Minier, Fabienne Contégal-Callier, Philippe Vion, Yvan Vaschalde, Mohammed El Amrani, Emilie, Mathieu Zuber, Marie Bruandet, Claire Join-Lambert, Pierre-Yves Garcia, Isabelle Serre, Jean-Marc Faucheux, Fatia Radji, Elena Leca-Radu, Thomas Debroucker, Rodica Cumurcuc, Serkan Cakmak, Stéphane Peysson, Emmanuel Ellie, Patricia Bernady, Thierry Moulin, Paola Montiel, Eugeniu Revenco, Pierre Decavel, Elisabeth Medeiros, Myriam Bouveret, Pierre Louchart, Claudia Vaduva, Grégory Couvreur, Eric Sartori, Eric Alnajar-Carpentier, Michèle Levasseur, Jean-Philippe Neau, Xavier Vandamme, Isabelle Meresse, null Stantescu, Canan Ozsancak, Katell Beauvais, Pascal Auzou, Joséphine Amevigbe, Francis Vuillemet, Marie-Hélène Dugay-Arentz, Gabriela Carelli, Mikel Martinez, Marcel Maillet-Vioud, Jean-Pierre Escaillas, Stéphane Chapuis, Jean Tardy, Eric Manchon, Olivier Varnet, Yong-Jae Kim, Yoonkyung Chang, Tae-Jin Song, Jung-Hoon Han, Kyung Chul Noh, Eun-Jae Lee, Dong-Wha Kang, Sun Uck Kwon, Boseoung Kwon, Seongho Park, Dongwhane Lee, Hyuk Sung Kwon, Daeun Jeong, MinHwan Lee, Joonggoo Kim, Hanbin Lee, Hyo Jung Nam, Sang Hun Lee, Bum Joon Kim, Jae-kwan Cha, DaeHyun Kim, Rae Young Kim, Sang Wuk Sohn, Dong-Hyun Shim, Hyungjin Lee, Hyun-Wook Nah, Sang Min Sung, Kyung Bok Lee, Jeong Yoon Lee, Jee Eun Yoon, Eung-Gyu Kim, Jung Hwa Seo, Yong-Won Kim, Yangha Hwang, Man Seok Park, Joon-Tae Kim, Kang-Ho Choi, Hyo Suk Nam, Ji Hoe Heo, Young Dae Kim, In Gun Hwang, Hyung Jong Park, Kyoung Sub Kim, Jang Hyun Baek, Dong Beom Song, Joon Sang Yoo, Jong-Moo Park, Ohyun Kwon, Woong-Woo Lee, Jung-Ju Lee, Kyusik Kang, Byung Kun Kim, Jae-Sung Lim, Mi Sun Oh, Kyung-Ho Yu, Bora Hong, Mihoon Jang, Seyoung Jang, Jung Eun Jin, Jei Kim, Hye Seon Jeong, Keun Sik Hong, Hong Kyun Park, Yong Jin Cho, Oh Young Bang, Woo-Keun Seo, Jongwon Chung, Laboratoire de Recherche Vasculaire Translationnelle (LVTS (UMR_S_1148 / U1148)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, Fibrose Inflammation Remodelage [Hôpitaux Universitaires Paris Nord Val de Seine] (DHU FIRE ), Hôpitaux Universitaires Paris Nord Val de Seine, AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Asan Medical Center [Seoul], University of Ulsan, Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Université de Bourgogne (UB), Hallym University Sacred Heart Hospital [Anyang, South Korea] (HUS2H), Hôpital Pasteur [Nice] (CHU), Hospices Civils de Lyon (HCL), Université de Lyon, Hôpitaux Universitaire Saint-Louis, Lariboisière, Fernand-Widal, Royal Brompton Hospital, CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Sorbonne Université (SU), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition [CHU Pitié Salpêtrière] (IHU ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Pitié-Salpêtrière [AP-HP], Treat Stroke to Target Investigators: Pierre-Jean Touboul, Didier Leys, Yannick Béjot, Philippa Lavallée, Fernando Pico, Emmanuel Touzé, Gregory Ducrocq, Jérémy Abtan, Olivier Varenne, Pierre-Jean Touboul, Agnes Kemmel, Fausta Syana, Manele Ledra, Tharani Nagasara, Mervette Ledjeroud, Bahous Samia, Hafirassou Hadia, Benyoub Hazare, Ikrame El Jaghouni, Nessima Yelles, Sofia Zemouri, Mervette Ladjeroud, Salim Kerai, Yun Jeong In, Elena Meseguer, Philippa C Lavallée, Cristina Hobeanu, Celine Guidoux, Lucie Cabrejo, Bertrand Lapergue, Candice Sabben, Jaime Gonzalez-Valcarcel, Ricardo Rigual, Gaia Sirimarco, Anna Martin-Bechet, Elena Viedma, Ioan Avram, Yves Samson, Charlotte Rosso, Sophie Crozier, Sara Leder, Anne Léger, Sandrine Deltour, Gurkan Mutlu, Marion Yger, Chiara Zavanone, Flore Baronnet, Christine Pires, Bertrand Lapergue, Adrien Wang, Serge Evrard, Maya Tchikviladze, Frédéric Bourdain, Delphine Lopez, Fernando Pico, Laetitia Bayon de la Tour, Marie-Laure Chadenat, Duc Long Duong, Solène Genty, Catherine Hirel, Gurkan Mutlu, Chantal Nifle, Jérôme Servan, Daniela Stanciu, Veronica Sudacevschi, Mélissa Tir, Anne-Cécile Troussière, Jennifer Yeung, Anne-Céline Zeghoudi, Ikram Tidafi-Bayou, Sylvain Lachaud, Tae-Hee Cho, Laura Mechtouff, Thomas Ritzenthaller, Laurent Derex, Carlo Albanesi, Elodie Ong, Amandine Benoit, Nadia Berhoune, Sandra Felix, Maud Esteban-Mader, Igor Sibon, Annabelle Kazadi, François Rouanet, Pauline Renou, Sabrina Debruxelles, Mathilde Poli, Sharmila Sagnier, Jean-Louis Mas, Valérie Domigo, Catherine Lamy, Eric Bodiguel, Jérôme Grimaud, Valentin Bohotin, Michael Obadia, Candice Sabben, Erwan Morvan, Gilles Rodier, Wilfried Vadot, Hilde Hénon, Charlotte Cordonnier, Frédéric Dumont, Marie Bodenant, Christian Lucas, Solène Moulin, Nelly Dequatre, Sonia Alamowitch, Jean-Paul Muresan, Thomas Drouet, Magalie Gallea, Marie-Amélie Dalloz, Stephen Delorme, Marion Yger, Yannick Béjot, Philippe Loisel, Carine Bonnin, Virginie Bernigal, Guy Victor Osseby, Marie Hervieu-Bègue Marsac, Pierre Garnier, Sandrine Accassat, Magali Epinat, Jérôme Varvat, Doïna Marinescu, Aude Triquenot-Bagan, Ozlem Ozkul-Wermester, Frédéric Philippeau, Angel Olaru, Anne Vieillart, Annie Lannuzel, Alice Demoly, Valérie Wolff, Mihaela Diaconu, Marc Bataillard, Francisco Macian Montoro, Frédéric Faugeras, Laeticia Gimenez, Françoise Abdallah-Lebeau, Serge Timsit, Irina Viakhireva-Dovganyuk, Anne Tirel-Badets, François-Mathias Merrien, Philippe Goas, François Rouhart, Aurore Jourdain, Benoit Guillon, Fanny Hérissson, Mathieu Sevin-Allouet, Nathalie Nasr, Jean-Marc Olivot, Alderic Lecluse, Guillaume Marc, Emmanuel Touzé, Vincent de la Sayette, Marion Apoil, Li Lin, Julien Cogez, Sophie Guettier, Olivier Godefroy, Chantal Lamy, Jean-Marc Bugnicourt, Grégory Taurin, Marc Mérienne, Julien Gere, Anne-Marie Chessak, Tarik Habet, Anna Ferrier, Nathalie Bourgois, Dominique Minier, Marie Caillier-Minier, Fabienne Contégal-Callier, Philippe Vion, Yvan Vaschalde, Mohammed El Amrani Emilie, Mathieu Zuber, Marie Bruandet, Claire Join-Lambert, Pierre-Yves Garcia, Isabelle Serre, Jean-Marc Faucheux, Fatia Radji, Elena Leca-Radu, Thomas Debroucker, Rodica Cumurcuc, Serkan Cakmak, Stéphane Peysson, Emmanuel Ellie, Patricia Bernady, Thierry Moulin, Paola Montiel, Eugeniu Revenco, Pierre Decavel, Elisabeth Medeiros, Myriam Bouveret, Pierre Louchart, Claudia Vaduva, Grégory Couvreur, Eric Sartori, Eric Alnajar-Carpentier, Michèle Levasseur, Pierre Louchart, Jean-Philippe Neau, Xavier Vandamme, Isabelle Meresse, Stantescu, Marc Bataillard, Canan Ozsancak, Katell Beauvais, Pascal Auzou, Joséphine Amevigbe, Francis Vuillemet, Marie-Hélène Dugay-Arentz, Gabriela Carelli, Mikel Martinez, Marcel Maillet-Vioud, Jean-Pierre Escaillas, Stéphane Chapuis, Jean Tardy, Eric Manchon, Olivier Varnet, Yong-Jae Kim, Yoonkyung Chang, Tae-Jin Song, Jung-Hoon Han, Kyung Chul Noh, Eun-Jae Lee, Dong-Wha Kang, Sun Uck Kwon, Boseoung Kwon, Seongho Park, Dongwhane Lee, Hyuk Sung Kwon, Daeun Jeong, MinHwan Lee, Joonggoo Kim, Hanbin Lee, Hyo Jung Nam, Sang Hun Lee, Bum Joon Kim, Jae-Kwan Cha, DaeHyun Kim, Rae Young Kim, Sang Wuk Sohn, Dong-Hyun Shim, Hyungjin Lee, Hyun-Wook Nah, Sang Min Sung, Kyung Bok Lee, Jeong Yoon Lee, Jee Eun Yoon, Eung-Gyu Kim, Jung Hwa Seo, Yong-Won Kim, Yangha Hwang, Man Seok Park, Joon-Tae Kim, Kang-Ho Choi, Hyo Suk Nam, Ji Hoe Heo, Young Dae Kim, In Gun Hwang, Hyung Jong Park, Kyoung Sub Kim, Jang Hyun Baek, Dong Beom Song, Joon Sang Yoo, Jong-Moo Park, Ohyun Kwon, Woong-Woo Lee, Jung-Ju Lee, Kyusik Kang, Byung Kun Kim, Jae-Sung Lim, Mi Sun Oh, Kyung-Ho Yu, Bora Hong, Mihoon Jang, Seyoung Jang, Jung Eun Jin, Jei Kim, Hye Seon Jeong, Keun Sik Hong, Hong Kyun Park, Yong Jin Cho, Oh Young Bang, Woo-Keun Seo, Jongwon Chung, and UPJV, BU Santé
Subjects: Male, medicine.medical_specialty, Statin, Time Factors, medicine.drug_class, [SDV]Life Sciences [q-bio], Brain Ischemia, LDL, chemistry.chemical_compound, Drug Delivery Systems, Ezetimibe, Internal medicine, medicine, Clinical endpoint, Humans, angiography, Myocardial infarction, Stroke, Aged, Advanced and Specialized Nursing, Cerebral infarction, Cholesterol, business.industry, Anticholesteremic Agents, informed consent, cholesterol, Cholesterol, LDL, Middle Aged, medicine.disease, stroke, [SDV] Life Sciences [q-bio], aorta, chemistry, Number needed to treat, Cardiology, Female, Neurology (clinical), Cardiology and Cardiovascular Medicine, business, medicine.drug
Abstract: Background and Purpose— The TST trial (Treat Stroke to Target) evaluated the benefit of targeting a LDL (low-density lipoprotein) cholesterol of 4 mm, in a French and Korean population. The follow-up lasted a median of 5.3 years in French patients (similar to the median follow-up time in the SPARCL trial [Stroke Prevention by Aggressive Reduction in Cholesterol Level]) and 2.0 years in Korean patients. Exposure duration to statin is a well-known driver for cardiovascular risk reduction. We report here the TST results in the French cohort. Methods— One thousand seventy-three French patients were assigned to Results— After a median follow-up of 5.3 years, the achieved LDL cholesterol was 66 (1.69 mmol/L) and 96 mg/dL (2.46 mmol/L) on average, respectively. The primary end point occurred in 9.6% and 12.9% of patients, respectively (HR, 0.74 [95% CI, 0.57–0.94]; P =0.019). Cerebral infarction or urgent carotid revascularization following transient ischemic attack was reduced by 27% ( P =0.046). Cerebral infarction or intracranial hemorrhage was reduced by 28% ( P =0.023). The primary outcome or intracranial hemorrhage was reduced by 25% ( P =0.021). Intracranial hemorrhages occurred in 13 and 11 patients, respectively (HR, 1.17 [95% CI, 0.53–2.62]; P =0.70). Conclusions— After an ischemic stroke of documented atherosclerotic origin, targeting a LDL cholesterol of Registration— URL: https://www.clinicaltrials.gov ; Unique identifier: NCT01252875.
Published: 2020
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6. Through the challenging synthesis of tetraphenylporphyrin derivatives bearing nitroxide moieties

Author: Catherine Hirel, Ismail Fidan, Emel Önal, Dominique Luneau, Department of chemistry - Gebze Technical University, Gebze Teknik Üniversitesi [Gebze], Acibadem University, Laboratoire des Multimatériaux et Interfaces (LMI), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Sabancı University SUNUM Nanotechnology Research Centre, and 0-Belirlenecek
Subjects: MALDI-TOF, Nitroxide mediated radical polymerization, Bearing (mechanical), 010405 organic chemistry, Chemistry, UV-vis, [CHIM.MATE]Chemical Sciences/Material chemistry, General Chemistry, QD241-441 Organic chemistry, 010402 general chemistry, Photochemistry, 01 natural sciences, Porphyrin, 0104 chemical sciences, law.invention, chemistry.chemical_compound, Ultraviolet visible spectroscopy, law, nitronyl and imino nitroxide, Tetraphenylporphyrin, [CHIM.CRIS]Chemical Sciences/Cristallography, [CHIM]Chemical Sciences, epr, Electron paramagnetic resonance, porphyrin
Abstract: Hirel, Catherine/0000-0002-6297-5650; LUNEAU, Dominique/0000-0002-1831-7693 Tetraphenylporphyrin derivatives a synthetic heterocycles with convenient preparation and a richness of properties which make them attractive in broad fields such as energy, life and materials sciences. Thus, in the quest for new radical architectures, tetraphenylporphyrins are prime candidates. To this end, we designed free-base tetraphenylporphyrins bearing nitronyl and imino nitroxide moieties covalently bonded to the para-position of the meso-phenyl substituent. Their detailed synthesis and characterization arc reported here. Scientific and Technological Research Council of Turkey-TUBITAKTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [113Z005] Financial support from the Scientific and Technological Research Council of Turkey-TUBITAK (project 113Z005) is gratefully acknowledged. The authors declare no competing financial interest.
Published: 2021
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7. Nitroxide radicals appended to phthalonitriles: synthesis, structural characterization and photophysical properties

Author: Catherine Hirel, Ismail Fidan, Emel Onal, and 0-Belirlenecek
Subjects: Nitroxide mediated radical polymerization, crystal structure, Radical, Substituent, Crystal structure, 010402 general chemistry, 01 natural sciences, law.invention, Inorganic Chemistry, Phthalonitrile, chemistry.chemical_compound, Nucleophilic aromatic substitution, law, redox properties, Materials Chemistry, phthalonitrile, Physical and Theoretical Chemistry, Electron paramagnetic resonance, 010405 organic chemistry, Condensed Matter Physics, EPR spectra, 0104 chemical sciences, stable radical, Crystallography, nitronyl nitroxide, chemistry, Cyclic voltammetry, imino nitroxide
Abstract: The syntheses of 4-[4-(4,4,5,5-tetramethyl-2-imidazoline-3-oxide-1-oxyl-2-yl)phenoxy]phthalonitrile (3, C21H19N4O3) and 4-[4-(4,4,5,5-tetramethyl-2-imidazoline-1-oxyl-2-yl)phenoxy]phthalonitrile (4) were carried out by microwave-assisted nucleophilic aromatic substitution of 4-nitrophthalonitrile (2) by the pre-formed 2-(4-hydroxyphenyl)-4,4,5,5-tetramethyl-2-imidazoline-3-oxide-1-oxyl (1). Compounds 3 and 4 were characterized unambiguously by a rich array of analyses, such as melting point, FT–IR, MALDI–TOF MS, elemental analysis, UV–Vis, CV, EPR, magnetic measurements and single-crystal X-ray diffraction. Structural studies demonstrate that the C—H...X and C—X...π (X = O and N) interactions in the radical nitronyl nitroxide groups play an important role in the assembly of the crystal structures. Moreover, cyclic voltammetry analyses show that the phthalonitrile substituent retains the redox properties of the Ullman radicals.
Published: 2020

8. Recognition of musical emotions and their perceived intensity after unilateral brain damage

Author: Catherine Hirel, Yohana Lévêque, Daniel Tranel, Amy M. Belfi, Norbert Nighoghossian, Lesly Fornoni, Anne Caclin, Julien Jung, Agathe Pralus, Emmanuel Bigand, Barbara Tillmann, Centre de recherche en neurosciences de Lyon (CRNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Department of Psychological Sciences, University of Missouri, Laboratoire d'Etude de l'Apprentissage et du Développement [Dijon] (LEAD), Centre National de la Recherche Scientifique (CNRS)-Université de Bourgogne (UB), Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL], Hospices Civils de Lyon (HCL), Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Tillmann, Barbara, Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center (CRNL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), and Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Valence hypothesis, Cognitive Neuroscience, Emotions, Experimental and Cognitive Psychology, Brain damage, Musical, Stimulus (physiology), Emotional processing, Right hemisphere hypothesis, 050105 experimental psychology, Lateralization of brain function, Functional Laterality, 03 medical and health sciences, [SCCO]Cognitive science, 0302 clinical medicine, Emotion perception, medicine, Humans, 0501 psychology and cognitive sciences, Valence (psychology), Cerebral Cortex, 05 social sciences, Recognition, Psychology, [SCCO] Cognitive science, Facial Expression, Neuropsychology and Physiological Psychology, Brain lesion, Laterality, medicine.symptom, Psychology, 030217 neurology & neurosurgery, Music, Cognitive psychology
Abstract: International audience; For the hemispheric laterality of emotion processing in the brain, two competing hypotheses are currently still debated. The first hypothesis suggests a greater involvement of the right hemisphere in emotion perception whereas the second hypothesis suggests different involvements of each hemisphere as a function of the valence of the emotion. These hypotheses are based on findings for facial and prosodic emotion perception. Investigating emotion perception for other stimuli, such as music, should provide further insight and potentially help to disentangle between these two hypotheses. The present study investigated musical emotion perception in patients with unilateral right brain damage (RBD, n = 16) or left brain damage (LBD, n = 16), as well as in matched healthy comparison participants (n = 28). The experimental task required explicit recognition of musical emotions as well as ratings on the perceived intensity of the emotion. Compared to matched comparison participants, musical emotion recognition was impaired only in LBD participants, suggesting a potential specificity of the left hemisphere for explicit emotion recognition in musical material. In contrast, intensity ratings of musical emotions revealed that RBD patients underestimated the intensity of negative emotions compared to positive emotions, while LBD patients and comparisons did not show this pattern. To control for a potential generalized emotion deficit for other types of stimuli, we also tested facial emotion recognition in the same patients and their matched healthy comparisons. This revealed that emotion recognition after brain damage might depend on the stimulus category or modality used. These results are in line with the hypothesis of a deficit of emotion perception depending on lesion laterality and valence in brain-damaged participants. The present findings provide critical information to disentangle the currently debated competing hypotheses and thus allow for a better characterization of the involvement of each hemisphere for explicit emotion recognition and their perceived intensity.
Published: 2020
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9. Revisiting the Ullman's Radical Chemistry for Phthalocyanine Derivatives

Author: Ismail Fidan, Catherine Hirel, Dominique Luneau, Vefa Ahsen, Department of chemistry - Gebze Technical University, Gebze Teknik Üniversitesi [Gebze], Laboratoire des Multimatériaux et Interfaces (LMI), Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Nitroxide mediated radical polymerization, Radical, Context (language use), 010402 general chemistry, Electrochemistry, 01 natural sciences, Catalysis, law.invention, chemistry.chemical_compound, law, Polymer chemistry, [CHIM]Chemical Sciences, Solubility, Electron paramagnetic resonance, Ullman's synthesis, radical, 010405 organic chemistry, Organic Chemistry, dehydration, [CHIM.MATE]Chemical Sciences/Material chemistry, General Chemistry, 0104 chemical sciences, chemistry, formys-substituted phthalocyanine, Phthalocyanine, Derivative (chemistry), imino nitroxide
Abstract: International audience; Phthalocyanine derivatives do not cease to gain attention due to their numerous properties and applications (e.g., sensor, PDT). This makes them a unique scaffold for the design of new material. In this context, we were interested to develop the synthesis of an imino nitroxide‐substituted phthalocyanine by Ullman's procedure; a challenge due to the intrinsic low solubility of most phthalocyanine derivative in much solvents. To overcome this solubility problem, we designed a phthalocyanine with bulky neopentyl substituents in peripheral positions as counterpart to the imino nitroxide moieties. The imino nitroxide‐substituted phthalocyanine was obtained by condensation of a monoformyl‐substituted phthalocyanine with 2,3‐bis(hydroxylamino)‐2,3‐dimethylbutane in refluxing THF–MeOH (2:1) mixture in the presence of p ‐toluenesulfonic acid monohydrate, follow by oxidation with PbO2. Characterization was performed by electrochemistry, UV/Vis and EPR spectroscopy in solution as well as SQUID in solid state.
Published: 2018
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10. Synthetic Access to a Pure Polyradical Architecture: Nucleophilic Insertion of Nitronyl Nitroxide on a Cyclotriphosphazene Scaffold

Author: Vefa Ahsen, Yusuf Yerli, Emel Önal, Dominique Luneau, Ismail Fidan, Catherine Hirel, Department of chemistry - Gebze Technical University, Gebze Teknik Üniversitesi [Gebze], Yildiz Technical University (YTU), Laboratoire des Multimatériaux et Interfaces (LMI), Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Nitroxide mediated radical polymerization, Materials science, 010405 organic chemistry, Stereochemistry, Radical, cyclotriphosphazene, [CHIM.MATE]Chemical Sciences/Material chemistry, General Chemistry, polyradicals, 010402 general chemistry, Electrochemistry, 01 natural sciences, Combinatorial chemistry, 0104 chemical sciences, chemistry.chemical_compound, nitronyl nitroxide, Monomer, electrochemistry, chemistry, Nucleophile, Nucleophilic substitution, [CHIM]Chemical Sciences, Polyphosphazene, nucleophilic substitution, Voltammetry
Abstract: International audience; An optimized nucleophilic synthetic approach featuring mild conditions and microwave energy was utilized to circumvent the classical Ullman procedure and access a polynitronyl nitroxide radical easily and in pure form. The simultaneous controlled introduction of preformed nitronyl nitroxide radicals on a cyclotriphosphazene core leads to a novel polyphosphazene monomer which is suitable for both n‐ and a p‐type redox‐active material in organic rechargeable batteries as demonstrated by electrochemistry. Additionally, absorption spectra and square‐wave voltammetry were utilized to quantify the number of nitronyl nitroxide radical units on the cyclotriphosphazene scaffold.
Published: 2017
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11. Verbal and musical short-term memory: Variety of auditory disorders after stroke

Author: Yohana Lévêque, Patrick Bouchet, Sébastien Daligault, Barbara Tillmann, Lesly Fornoni, Anne Caclin, Julien Jung, Norbert Nighoghossian, Salem Hannoun, Catherine Hirel, Centre de recherche en neurosciences de Lyon (CRNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hospices Civils de Lyon (HCL), Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre d'Etude et de Recherche Multimodal Et Pluridisciplinaire en imagerie du vivant (CERMEP - imagerie du vivant), Université de Lyon-Université de Lyon-CHU Grenoble-Hospices Civils de Lyon (HCL)-CHU Saint-Etienne-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Hospices Civils de Lyon, Departement de Neurologie (HCL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), and Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Adult, Male, Melody, Cognitive Neuroscience, Short-term memory, Experimental and Cognitive Psychology, Neuropsychological Tests, Amusia, computer.software_genre, behavioral disciplines and activities, 050105 experimental psychology, Brain Ischemia, 03 medical and health sciences, 0302 clinical medicine, Arts and Humanities (miscellaneous), Voxel, Aphasia, Developmental and Educational Psychology, medicine, Humans, 0501 psychology and cognitive sciences, Neuropsychological assessment, Stroke, Aged, Aged, 80 and over, medicine.diagnostic_test, [SCCO.NEUR]Cognitive science/Neuroscience, 05 social sciences, Cognition, Middle Aged, medicine.disease, Memory, Short-Term, Neuropsychology and Physiological Psychology, Female, medicine.symptom, Psychology, computer, Music, 030217 neurology & neurosurgery, Cognitive psychology
Abstract: International audience; Auditory cognitive deficits after stroke may concern language and/or music processing, resulting in aphasia and/or amusia. The aim of the present study was to assess the potential deficits of auditory short-term memory for verbal and musical material after stroke and their underlying cerebral correlates with a Voxel-based Lesion Symptom Mapping approach (VLSM). Patients with an ischemic stroke in the right (N=10) or left (N=10) middle cerebral artery territory and matched control participants (N=14) were tested with a detailed neuropsychological assessment including global cognitive functions, music perception and language tasks. All participants then performed verbal and musical auditory short-term memory (STM) tasks that were implemented in the same way for both materials. Participants had to indicate whether series of four words or four tones presented in pairs, were the same or different. To detect domain-general STM deficits, they also had to perform a visual STM task. Behavioral results showed that patients had lower performance for the STM tasks in comparison with control participants, regardless of the material (words, tones, visual) and the lesion side. The individual patient data showed a double dissociation between some patients exhibiting verbal deficits without musical deficits or the reverse. Exploratory VLSM analyses suggested that dorsal pathways are involved in verbal (phonetic), musical (melodic), and visual STM, while the ventral auditory pathway is involved in musical STM.
Published: 2017
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12. Development Of Optical Chemical Nanosensors For The Analysis Of Reactive Gases Such As Nitric Oxide And Ammonia In Closed Workplaces

Author: ÖTER, ÖZLEM, Yıldız, Sevinç Zehra, ÖNAL, EMEL, Doğan, Cansu, and Catherine, Hirel
Published: 2019

13. Synthesis and Straightforward Quantification Methods of Imino Nitroxide-Based Hexaradical Architecture on a Cyclotriphosphazene Scaffold

Author: Vefa Ahsen, Emel Önal, Catherine Hirel, Yusuf Yerli, Ismail Fidan, Dominique Luneau, Department of chemistry - Gebze Technical University, Gebze Teknik Üniversitesi [Gebze], Yildiz Technical University (YTU), Laboratoire des Multimatériaux et Interfaces (LMI), Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Scaffolds, Nitroxide mediated radical polymerization, Quantification methods, Absorption spectroscopy, 010405 organic chemistry, Chemistry, Condensation, [CHIM.MATE]Chemical Sciences/Material chemistry, 010402 general chemistry, Electrochemistry, 01 natural sciences, 0104 chemical sciences, law.invention, Inorganic Chemistry, law, Covalent bond, Oxidation, Polymer chemistry, [CHIM]Chemical Sciences, Redox reactions, Physical and Theoretical Chemistry, Electron paramagnetic resonance, Spectroscopy, Molecular structure, Electron paramagnetic resonance spectroscopy
Abstract: International audience; The synthesis of a homogeneous neutral hexaradical architecture consisting of six imino nitroxide radical moieties covalently bonded on a cyclotriphosphazene scaffold was reported. The synthesis of hexaradical imino nitroxide compounds follows the Ullman procedure involving the condensation of 2,3-bis(hydroxylamino)-2,3-dimethylbutane with hexa-(4-formylphenoxy)cyclotriphosphazene (3) followed by oxidation of the condensation product hexa-[4-(1-hydroxy-4,4,5,5-tetramethyl-2-imidazoline-2-yl)phenoxy]cyclotriphosphazene (2) by NaIO4. Characterization of hexaradical was performed by X-ray and SQUID in solid state and by EPR, absorption spectroscopy, and electrochemistry in solution. CV of 1 shows an oxidation peak at 1.184 V (vs SCE) and a reduction peak at −0.883 V, both characteristics of the presence of phenyl imino nitroxide (7) moieties, suggesting that the contribution of the cyclotriphosphazene core is negligible. Attention was particularly focused on developing methods, UV–vis spectroscopy and square-wave voltammetry, to quantify the number of radicals in a way to confirm easily and rapidly the polyradicals’ structure.
Published: 2016
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14. Effect of In-Hospital Remote Ischemic Perconditioning on Brain Infarction Growth and Clinical Outcomes in Patients With Acute Ischemic Stroke

Author: Amina Cattenoy, Pierre Amarenco, Frédéric Bourdain, Michael Obadia, Marc Ferrigno, Valérie Wolff, Charlotte Cordonnier, Marie-Laure Chadenat, Duc Long Duong, Didier Smadja, Elena Meseguer, Benoit Guillon, Yves Samson, Sandrine Deltour, Hassan Hosseini, Catherine Hirel, Charlotte Rosso, Fernando Pico, Bertrand Lapergue, Philippe Aegerter, and Julien Labreuche
Subjects: Intracerebral hemorrhage, Randomization, business.industry, medicine.medical_treatment, Thrombolysis, medicine.disease, law.invention, Clinical trial, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, Interquartile range, Modified Rankin Scale, law, Anesthesia, medicine, 030212 general & internal medicine, Neurology (clinical), business, Stroke, 030217 neurology & neurosurgery, Original Investigation
Abstract: IMPORTANCE: Treatment with remote ischemic perconditioning has been reported to reduce brain infarction volume in animal models of stroke. Whether this neuroprotective effect was observed in patients with acute ischemic stroke remains unknown. OBJECTIVE: To determine whether treatment with remote ischemic perconditioning administered to the leg of patients with acute ischemic stroke can reduce brain infarction volume growth. DESIGN, SETTING, AND PARTICIPANTS: This proof-of-concept multicenter prospective randomized open-label with blinded end point clinical trial was performed from January 12, 2015, to May 2, 2018. Patients were recruited from 11 stroke centers in France. Of the 188 patients who received magnetic resonance imaging within 6 hours of symptom onset and were confirmed to have carotid ischemic stroke, 93 were randomized to receive treatment with lower-limb remote ischemic perconditioning in addition to standard care (the intervention group), and 95 were randomized to receive standard care alone (the control group). INTERVENTIONS: Randomization on a 1:1 ratio to receive treatment with remote ischemic perconditioning (4 cycles of 5-minute inflations and 5-minute deflations to the thigh to 110 mm Hg above systolic blood pressure) in addition to standard care or standard care alone. MAIN OUTCOMES AND MEASURES: The change in brain infarction volume growth between baseline and 24 hours, measured by a diffusion-weighted sequence of magnetic resonance imaging scans of the brain. RESULTS: A total of 188 patients (mean [SD] age, 67.2 [15.7] years; 98 men [52.1%]) were included in this intention-to-treat analysis. At hospital admission, the median National Institutes of Health Stroke Scale score was 10 (interquartile range [IQR], 6-16) and the median brain infarction volume was 11.4 cm(3) (IQR, 3.6-35.8 cm(3)); 164 patients (87.2%) received intravenous thrombolysis, and 64 patients (34.0%) underwent mechanical thrombectomy. The median increase in brain infarction growth was 0.30 cm(3) (IQR, 0.11-0.48 cm(3)) in the intervention group and 0.37 cm(3) (IQR, 0.19-0.55 cm(3)) in the control group (mean between-group difference on log(e)-transformed change, –0.07; 95% CI, –0.33 to 0.18; P = .57). An excellent outcome (defined as a score of 0-1 on the 90-day modified Rankin Scale or a score equal to the prestroke modified Rankin Scale score) was observed in 46 of 90 patients (51.1%) in the intervention group and 37 of 91 patients (40.7%) in the control group (P = .12). No significant differences in 90-day mortality were observed between the intervention and control groups (14 of 90 patients; Kaplan-Meier estimate, 15.8% vs 10 of 91 patients; Kaplan-Meier estimate, 10.4%, respectively; P = .45) or with symptomatic intracerebral hemorrhage (4 of 88 patients [4.5%] in both groups; P = .97). CONCLUSIONS AND RELEVANCE: In this study, treatment with remote ischemic perconditioning, during or after reperfusion therapies, had no significant effect on brain infarction volume growth at 24 hours after symptom onset. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT02189928
Published: 2020
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15. Improvement of the O2 detection: Substituent’s effect on Pd(II) mesotetraphenylporphyrin probes

Author: Zübeyde Yel, Sevinc Zehra Topal, Kadriye Ertekin, Catherine Hirel, Merve Zeyrek Ongun, Emel Önal, Doğuş Üniversitesi, Mühendislik Fakültesi, Endüstri Mühendisliği Bölümü, and Önal Dumanlıoğlu, Emel
Subjects: Materials science, Luminescence, Substituent, Nanofibers, chemistry.chemical_element, Context (language use), Electron donor, 02 engineering and technology, 010402 general chemistry, Photochemistry, Propyne, 01 natural sciences, Silver nanoparticle, chemistry.chemical_compound, Sensitivity, Oxygen Sensor, Complex, Tetraphenylporphyrin, Optical Oxygen-Sensors, Materials Chemistry, Electrical and Electronic Engineering, Instrumentation, Palladium Meso-Tetraphenylporphyrins, Enhancement, Phosphorescence, Poly(1-trimethylsilyl-1-propyne), Metals and Alloys, Silver Nanoparticles (AgNPs), 021001 nanoscience & nanotechnology, Condensed Matter Physics, 0104 chemical sciences, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, chemistry, Microfibers, 0210 nano-technology, Pt(Ii), Palladium
Abstract: Luminescence-based sensors are among the most promising tools for detection of oxygen gas. Improving the performance of such sensors is still an issue that requires an optimization of its composition which includes an oxygen sensitive probe embedded in a polymeric matrix with or without additives. Our approach is based on design of oxygen sensitive probes and aims at understanding the relationship between the structural variation of the probe and its oxygen sensing ability. In this context, our choice focuses on a non-symmetric palladium meso-tetraphenylporphyrin bearing three electron donor hexyloxy (-OC6H13) and one electron withdrawing phenylacetylide substituents (3-Pd). Poly (trimethylsilyl propyne) [poly(TMSP)] was privileged as polymeric matrix material due to is high oxygen permeability, also silver nanoparticles (AgNPs) were added to magnify the sensor sensitivity. The AgNP supported 3-Pd-doped poly(TMSP) microfiber [AgNP-(3-Pd)MF] in its optimal composition shows an exceptional intensity ratio value I-0/I-100 = 335, a high Stern-Volmer constant (K-SV = 6.4274%(-1)), a short response time (2 s), and quite low limit of detection (4.66 x 10(-4)%(-1)). Dokuz Eylul UniversityDokuz Eylul University The authors thank the Dokuz Eylul University for the BAP funding, and also Eren Jason Gurbuz for the design of Scheme 1.
Published: 2019

16. Effect of the Substitution Pattern (Peripheral vs Non-Peripheral) on the Spectroscopic, Electrochemical, and Magnetic Properties of Octahexylsulfanyl Copper Phthalocyanines

Author: Vefa Ahsen, Yunus Zorlu, Yurii Chumakov, Yan Cui, Lihan Zeng, Sibel Tokdemir Öztürk, Catherine Hirel, Fabienne Dumoulin, A. A. Chernonosov, Karl M. Kadish, Ismail Fidan, Tulin Ateş Turkmen, and Ayşe Gül Gürek
Subjects: 010405 organic chemistry, Band gap, Resonance, chemistry.chemical_element, 010402 general chemistry, Electrochemistry, 01 natural sciences, Copper, Spectral line, 0104 chemical sciences, Inorganic Chemistry, Paramagnetism, chemistry, Physical chemistry, Physical and Theoretical Chemistry, Absorption (chemistry), Anisotropy
Abstract: In order to investigate the substitution position effect on the spectroscopic, electrochemical, and magnetic properties of copper phthalocyanines, a detailed structure–property analysis has been performed by examining two copper phthalocyanines that are octasubstituted by hexylsulfanyl chains respectively in the peripheral (Cu-P) and non-peripheral (Cu-NP) positions. Cu-NP showed a marked near-IR maximum absorption compared to Cu-P and, accordingly, a smaller HOMO–LUMO energy gap, calculated via the electrochemical results and simulations in the gas phase, as well as for Cu-NP from its crystallographic data. An electron-spin resonance (ESR) technique is used to extract the g values from the powder spectra that are taken at room temperature. The g values were determined to be g∥ = 2.160 and g⊥ = 2.045 for Cu-P and g∥ = 2.150 and g⊥ = 2.050 for Cu-NP. These values indicate that the paramagnetic copper center in both phthalocyanines has axial symmetry with a planar anisotropy (g∥ > g⊥). The ESR spectra in so...
Published: 2018

17. Hyperporphyrin effect on oxygen sensitivity of free meso-tetraphenylporphyrins

Author: Catherine Hirel, Emel Önal, Sevinc Zehra Topal, Kadriye Ertekin, and Merve Zeyrek Ongun
Subjects: Process Chemistry and Technology, General Chemical Engineering, Substituent, Protonation, Electron donor, 02 engineering and technology, 010402 general chemistry, 021001 nanoscience & nanotechnology, Photochemistry, 01 natural sciences, 0104 chemical sciences, Absorbance, chemistry.chemical_compound, chemistry, Ionic liquid, Tetraphenylporphyrin, Luminophore, Titration, 0210 nano-technology
Abstract: A series of dyes; three symmetric free meso-tetraphenylporphyrins, bearing phenylacetylide (H2-TPA), hexyloxy (H2-OHex) or without peripheral substituent (H2-TPP) were chosen as luminophore to explore the effect of meso-substitution on the oxygen sensing ability. These dyes were incorporated into poly(trimethylsilylpropyne) [poly(TMSP)], polymethylmethacrylate (PMMA) and silicone matrices along with additives such as perfluorododecanoic acid (PFC) to improve the oxygen sensitivity as well as ionic liquid to favor the microfiber preparation by electrospinning. The pH of the medium is affected by the composition of the cocktail, a non-trivial effect which induce protonation of the free meso-tetraphenylporphyrin derivatives bearing electron donor (H2-OHex) and withdrawing substituents (H2-TPA), which results in absorbance and emission spectroscopic modifications called elsewhere hyperporphyrin effect. Spectrophotometric titrations were carried out by using HClO4 in THE solution and PFC in [poly(TMSP)]-based thin film to study the hyperporphyrin effect of H2-TPA, H2-OHex and H2-TPP showing the influence of the substituent bn the pKa of the inner nitrogen's. The ratio of PFC/dyes optimization was prospected and the influence of the pH/protonation on the steady-state oxygen sensitivity was studied. (C) 2017 Elsevier Ltd. All rights reserved.
Published: 2017

18. Musical Connections

Author: Barbara Tillmann, Anne Caclin, Yohana Lévêque, and Catherine Hirel
Subjects: Music perception, Musical, Psychology, Cognitive psychology
Published: 2017
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19. Lifetime-Based Oxygen Sensing Properties of palladium(II) and platinum(II) meso-tetrakis(4-phenylethynyl)phenylporphyrin

Author: Michael U. Kumke, Emel Önal, Jeanne Hurpin, Sevinc Zehra Topal, Catherine Hirel, Kadriye Ertekin, and Stephan Saß
Subjects: Sociology and Political Science, Clinical Biochemistry, chemistry.chemical_element, 02 engineering and technology, 010402 general chemistry, Photochemistry, 01 natural sciences, Biochemistry, Silver nanoparticle, Metal, chemistry.chemical_compound, Spectroscopy, 021001 nanoscience & nanotechnology, Porphyrin, 0104 chemical sciences, Clinical Psychology, chemistry, visual_art, Nanofiber, visual_art.visual_art_medium, Institut für Chemie, 0210 nano-technology, Phosphorescence, Platinum, Luminescence, Law, Social Sciences (miscellaneous), Palladium
Abstract: High oxygen permeable [poly(TMSP)] nanofibers incorporating porphyrin macrocycle as luminescence indicators were prepared by electrospinning technique. The porphyrins involves were modified by i) introducing phenylacetylide substituents on the para position of the phenyl moieties and ii) varying the metal centers [Pt(II) or Pd(II)] of the meso-tetrakisphenylporphyrins. A set of nanofibers; (Pt-TPP)NF, (Pd-TPP)NF, (Pt-TPA)NF and (Pd-TPA)NF were obtained to study their structure-activity relationship toward oxygen. The lifetime-based technique was privileged to take advantage of their long-lived phosphorescent properties. A two-fold enhancement was observed for (Pt-TPA)NF and (Pd-TPA)NF compared to (Pt-TPP)NF and (Pd-TPP)NF demonstrating the positive effect of the phenylacetylide moieties on the lifetime. Also, Silver nanoparticles were included in nanofibers to investigate their influence on lifetime-based oxygen sensitivity, showing that the presence of AgNPs only affects (Pd-TPA)NF.
Published: 2017

20. ABAB Homoleptic Bis(phthalocyaninato)lanthanide(III) Complexes: Original Octupolar Design Leading to Giant Quadratic Hyperpolarizability

Author: Vefa Ahsen, Erwann Jeanneau, Isabelle Ledoux-Rak, Mehmet Menaf Ayhan, Joseph Zyss, Chantal Andraud, Yann Bretonnière, Anu Singh, Ayşe Gül Gürek, Catherine Hirel, Laboratoire de Chimie - UMR5182 (LC), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-École normale supérieure - Lyon (ENS Lyon)-Institut de Chimie du CNRS (INC), Laboratoire Traitement et Communication de l'Information (LTCI), Télécom ParisTech-Institut Mines-Télécom [Paris] (IMT)-Centre National de la Recherche Scientifique (CNRS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon, France Telecom, Centre National d'Etudes de Télécommunications, Laboratoire de Bagneux (CNET Bagneux), CNET, Laboratoire de Photonique Quantique et Moléculaire (LPQM), École normale supérieure - Cachan (ENS Cachan)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Lanthanide, [CHIM.ORGA]Chemical Sciences/Organic chemistry, Hyperpolarizability, [CHIM.CATA]Chemical Sciences/Catalysis, [CHIM.MATE]Chemical Sciences/Material chemistry, Crystal structure, [CHIM.INOR]Chemical Sciences/Inorganic chemistry, Ion, Inorganic Chemistry, Delocalized electron, chemistry.chemical_compound, Crystallography, chemistry, Computational chemistry, Phthalocyanine, Molecule, Physical and Theoretical Chemistry, Homoleptic, ComputingMilieux_MISCELLANEOUS
Abstract: The octupolar cube, a T-d symmetry cube presenting alternating charges at its corners, is the generic point charge template of any octupolar molecule. So far, transposition into real molecular structures has yet to be achieved. We report here a first step toward the elaboration of fully cubic octupolar architectures. A series of octupolar bis(2,3,16,17-tetra(hexylthio)phthalocyaninato)lanthanide double-decker complexes [Pc(2)Ln], Ln = Nd (1), Eu (2), Dy (3), Y (4), and Lu (5), are described, whose original three-dimensional structures display the required alternation of ABAB type for one face of the cube and the delocalization between the two rings approximating to the electronic interaction along the edges of the cube. Synthesis, X-ray crystal structure, and study of the optical properties and of the first molecular hyperpolarizability beta are reported. The size of the lanthanide (III) central ion modulates the ring-to-ring distance and the degree of coupling between the two phthalocyanine rings. As a consequence, the optical properties of these octupolar chromophores and in particular the strong near-infrared absorption due to the intervalence transition between the two rings also depend on the central lanthanide (III) ion. The first oxidized and reduced states of the complexes, while keeping a similar octupolar structure, display considerably changed optical properties compared to the neutral states. Second-order nonlinear properties were determined by nonpolarized harmonic light scattering in solution at 1907 nm. Exceptionally large dynamic molecular first hyperpolarizabilities root (1907), among the highest ever reported, were found that showed a strong dependence on the number of 4f electrons.
Published: 2014
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21. Nitronyl and imino nitroxide free radicals as precursors of magnetic phthalocyanine and porphyrin building blocks

Author: Emel Önal, Vefa Ahsen, Yusuf Yerli, Guillaume Pilet, Catherine Hirel, Dominique Luneau, Bünyemin Çoşut, Laboratoire des Multimatériaux et Interfaces (LMI), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Department of chemistry - Gebze Technical University, and Gebze Teknik Üniversitesi [Gebze]
Subjects: Nitroxide mediated radical polymerization, Electrospray ionization, Radical, [CHIM.MATE]Chemical Sciences/Material chemistry, General Chemistry, Mass spectrometry, Photochemistry, Porphyrin, Catalysis, law.invention, Phthalonitrile, chemistry.chemical_compound, chemistry, law, [CHIM.CRIS]Chemical Sciences/Cristallography, Materials Chemistry, Phthalocyanine, [CHIM]Chemical Sciences, Electron paramagnetic resonance
Abstract: International audience; Phthalonitrile and benzaldehyde bearing α-nitronyl and α-imino nitroxide free radicals have been synthesized as precursors of nitroxide substituted phthalocyanine and porphyrin macrocycles. To ascertain the structure and radical type they have been characterized by single crystal X-ray crystallography and by electron paramagnetic resonance spectroscopy (EPR). Their EPR spectra coincide with those reported for previous nitroxides and are in good agreement with literature. Electrospray ionization mass spectroscopy (ESI) was used as a complementary and an alternative technique. Depending on the nature of the radical, two ionization behaviors have been underscored; imino radicals were detected as the [MH2]+ cation ions and nitroxide radicals were detected as the [MH]+˙ radical cations. This differentiation is pointed out as an efficient and rapid method for preliminary characterization of the radical moieties and a judicious technique that allows the prompt detection of radicals at low concentration and straightforward confirmation of the structure.
Published: 2014
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22. Phthalonitriles Functionalized for Click Chemistry. Design, Synthesis and Structural Characterization

Author: Yunus Zorlu, İlker Ün, Vefa Ahsen, Fabienne Dumoulin, and Catherine Hirel
Subjects: chemistry.chemical_classification, Addition reaction, Alkyne, General Chemistry, Condensed Matter Physics, Combinatorial chemistry, Characterization (materials science), Phthalonitrile, chemistry.chemical_compound, chemistry, Design synthesis, Polymer chemistry, Click chemistry, Azide, Organometallic chemistry
Abstract: Two phthalonitriles complementarily functionalized by an azide and an alkyne function have been designed for the click Huisgen azide-alkyne dipolar addition reaction. Their synthesis and full structural characterization is presented here with a comparative approach. Two phthalonitriles complementarily functionalized by an azide and an alkyne function and their full structural characterization is presented with a comparative approach. .
Published: 2013
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23. Structure-Photoproperties Relationship Investigation of the Singlet Oxygen Formation in Porphyrin-Fullerene Dyads

Author: Savas Berber, Fabienne Dumoulin, Sevinc Zehra Topal, Ismail Fidan, Emel Önal, and Catherine Hirel
Subjects: Fullerene, Sociology and Political Science, Singlet oxygen, Clinical Biochemistry, chemistry.chemical_element, 02 engineering and technology, 010402 general chemistry, 021001 nanoscience & nanotechnology, Electrochemistry, Photochemistry, 01 natural sciences, Biochemistry, Oxygen, Porphyrin, 0104 chemical sciences, Clinical Psychology, chemistry.chemical_compound, chemistry, Phenylacetylene, Molecular orbital, 0210 nano-technology, Ground state, Law, Spectroscopy, Social Sciences (miscellaneous)
Abstract: A systematic structure-photoproperties relationship study of the interactions of porphyrin-fullerene dyads with molecular oxygen was conducted on a set of three porphyrin-fullerene dyads, as this approach of related applications - oxygen sensitivity and photo-induced singlet oxygen generation - of such dyads remained to be endeavoured. To promote energy transfers between the porphyrin and fullerene units and limit undesired charge separation, a particular attention was devoted to the choice of the solvents for the photoproperties determination. Toluene, in which in addition the compounds investigated are not aggregated, was selected accordingly. The molecular orbital levels and energy gaps of the dyads were determined by electrochemistry and theoretical calculations. Their ground state absorption, steady-state fluorescence-based oxygen sensitivity and photo-induced singlet oxygen generation were determined. The dyads were designed to benefit from a facilitated synthetic porphyrin-fullerene coupling thanks to an easy access to formyl-functionalized porphyrins. The effect of two structural parameters was investigated: the presence of electron-donating hexyloxy chains at the para position of the meso-phenyl, and the presence of a phenylacetylene spacer. This latest factor appeared to have the most predominant effect on all these properties.
Published: 2017

24. Mechanism Of The Zn(Ii)Phthalocyanines' Photochemical Reactions Depending On The Number Of Substituents And Geometry

Author: Catherine Hirel, Leonardo De Boni, J. P. Siqueira, Ayşe Gül Gürek, Yann Bretonnière, Mehmet Menaf Ayhan, Cleber Renato Mendonça, Fernando Gotardo, Leandro H. Z. Cocca, Vefa Ahsen, Instituto de Física de São Carlos (IFSC-USP), Universidade de São Paulo = University of São Paulo (USP), Department of chemistry - Gebze Technical University, Gebze Teknik Üniversitesi [Gebze], Laboratoire de Chimie - UMR5182 (LC), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Universidade de São Paulo (USP), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-École normale supérieure - Lyon (ENS Lyon)-Institut de Chimie du CNRS (INC)
Subjects: Indoles, Zn(II)phthalocyanine, optical nonlinearities, luminescence, Population, Pharmaceutical Science, Quantum yield, Isoindoles, [CHIM.INOR]Chemical Sciences/Inorganic chemistry, 010402 general chemistry, Photochemistry, 01 natural sciences, Article, Analytical Chemistry, lcsh:QD241-441, lcsh:Organic chemistry, Drug Discovery, Organometallic Compounds, Singlet state, Physical and Theoretical Chemistry, Absorption (electromagnetic radiation), Spectroscopy, education, education.field_of_study, 010405 organic chemistry, Chemistry, [CHIM.ORGA]Chemical Sciences/Organic chemistry, Organic Chemistry, [CHIM.CATA]Chemical Sciences/Catalysis, [CHIM.MATE]Chemical Sciences/Material chemistry, Internal conversion (chemistry), Photochemical Processes, PROTEÍNAS, 0104 chemical sciences, Intersystem crossing, Spectrometry, Fluorescence, Chemistry (miscellaneous), Zinc Compounds, Excited state, Molecular Medicine
Abstract: International audience; In this work, the synthesis and the nonlinear absorption and population dynamics investigation of a series of zinc phthalocyanines (ZnPcs) dissolved in chloroform are reported. In order to determine the relevant spectroscopic parameters, such as absorption cross-sections of singlet and triplet excited states, fluorescence relaxation times, intersystem crossing, radiative decay and internal conversion, different optical and spectroscopic techniques were used. By single pulse and pulse train Z-scan techniques, respectively, singlet and triplet excited states‘ absorption cross-section were determined at 532 nm. Furthermore, the intersystem crossing time was obtained by using both techniques combined with the fluorescence lifetime determined by time-resolved fluorescence. The radiative and internal conversion rates were determined from the fluorescence quantum yield of the samples. Such spectroscopy parameters are fundamental for selecting photosensitizers used in photodynamic therapy, as well as for many other applications.
Published: 2016
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25. Design of oxygen sensing nanomaterial: synthesis, encapsulation of phenylacetylide substituted Pd(II) and Pt(II) meso-tetraphenylporphyrins into poly(1-trimethylsilyl-1-propyne) nanofibers and influence of silver nanoparticles

Author: Zübeyde Yel, Kadriye Ertekin, Sevinc Zehra Topal, Zeynep Ay, Catherine Hirel, Ayşe Gül Gürek, and Emel Önal
Subjects: Materials science, General Chemical Engineering, Inorganic chemistry, chemistry.chemical_element, Sonogashira coupling, 02 engineering and technology, General Chemistry, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, Silver nanoparticle, 0104 chemical sciences, chemistry, Nanofiber, Limiting oxygen concentration, 0210 nano-technology, Phosphorescence, Platinum, Oxygen sensor, Palladium
Abstract: Room temperature phosphorescent oxygen sensors have been designed by embedding symmetric palladium(II) or platinum(II) meso-tetraphenylporphyrins in poly(1-trimethylsilyl-1-propyne) in the form of nanofibers along with/without silver nanoparticles. These materials combine the advantages of the high oxygen sensitivity of porphyrins and the enhanced surface area of porous nanofibers. Phenylacetylide bearing palladium(II) or platinum(II) meso-tetraphenylporphyrins (Pd-TPA, Pt-TPA, Pd-TPP and Pt-TPP) were designed to enhance phosphorescence quantum yields as well as sensitivity towards oxygen. Their syntheses were achieved by 2 alternative methods including successive metallation reactions and Sonogashira coupling via optimization of the synthetic strategies and conditions. The respective effect of the metal (Pd or Pt) and substituent on phosphorescence quantum yield as well as other photophysical properties was considered. The sensing performances of the corresponding silver-free and silver doped nanofibers were tested in the oxygen concentration range of 0.0-100.0%. The offered composites provided the advantages of fast response, enhanced sensitivity, reversible and long lasting response, higher Stern-Volmer constants (KSV) and low limit of detection values extending to 7.5 ppm for oxygen.
Published: 2016

26. New Spin-Transition-Like Copper(II)−Nitroxide Species

Author: Licun Li, Paul Rey, Maxime Bernard, Kira E. Vostrikova, Peter Brough, Philippe Turek, Catherine Hirel, B. Mehdaoui, and Jacques Pécaut
Subjects: Nitroxide mediated radical polymerization, Chemistry, Ligand, Metal ions in aqueous solution, Spin transition, chemistry.chemical_element, Photochemistry, Copper, law.invention, Inorganic Chemistry, Metal, Crystallography, law, visual_art, visual_art.visual_art_medium, Physical and Theoretical Chemistry, Crystallization, Stoichiometry
Abstract: Novel copper(II)-nitroxide complexes exhibiting a spin-transition-like behavior have been prepared and characterized. They include meso, chiral, and racemic 2-(3-pyridyl)-nitronyl nitroxides differently substituted in positions 4 and/or 5 by ethyl groups and pyrimidyl nitroxides. Depending on the stoichiometry of the reaction, tetranuclear and binuclear complexes were obtained whose structures are cyclic. The tetranuclear species, which include two intracyclic and two exocyclic metal sites, are similar to the previously reported complex of the tetramethylated analogue, while the binuclear complexes involve only endocyclic metal ions and have uncoordinated N-oxyl groups. The tetranuclear complexes exist as two isomers depending on the temperature of crystallization: at room temperature, N-oxyl ligand coordination is axial-axial, while it is axial-equatorial at low temperature. Unexpectedly, this isomerism concerns N-oxyl bonding to the exocyclic metal centers for the derivatives of 4,5-diethyl-substituted ligands while it involves the endocyclic metal site in the complex of the monoethylated ligand, which converts reversibly from a high-spin state to a low-spin state, as observed for the complex of the tetramethylated ligand. Binuclear complexes are diamagnetic at room temperature but convert to a paramagnetic state on warming (90-110 degrees C); the transition is irreversible and sharp.
Published: 2007
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27. Enantiopure and Racemic Chiral Nitronyl Nitroxide Free Radicals: Synthesis and Characterization

Author: David B. Amabilino, Paul Rey, Jacques Pécaut, Philippe Turek, Jaume Veciana, Sylvie Choua, and Catherine Hirel
Subjects: chemistry.chemical_classification, Nitroxide mediated radical polymerization, Stereochemistry, Organic Chemistry, Diastereomer, Absolute configuration, Coordination complex, chemistry.chemical_compound, Enantiopure drug, chemistry, Imidazolidine, Polymer chemistry, Physical and Theoretical Chemistry, Chirality (chemistry), Imidazolidines
Abstract: A synthetic route to a series of homochiral (and achiral) nitronyl nitroxides derived from rac-(and meso)-3,4-dimethyl-3,4-dinitrohexane is described. The two forms of this precursor, meso and rac, were identified unambiguously and reduced to the corresponding meso- and rac-diamines. The rac-diamine was condensed with an enantiopure aldehyde specifically designed to give a diastereomeric mixture of imidazolidines easily separated by flash chromatography. Both enantiopure diamines were then obtained by acidic hydrolysis of these imidazolidines. The absolute configurations of the diamino precursors were determined by X-ray crystallography of single crystals of a manganese(II) complex [(R,R,R)-5E·Mn(hfac)2] of a nitroxide containing a third chiral center of known configuration. A series of homochiral nitronyl nitroxides was then prepared from the enantiopure diamino precursors by condensation with aldehydes, followed by oxidation. Their structural properties were compared to those of their achiral meso counterparts and it was found that the puckering of the five-membered ring is dependent on the chirality of the imidazolyl unit. The radicals show marked optical activity, as explored by polarimetry and circular dichroism spectroscopy. These paramagnetic building blocks of known absolute configuration include chiral centers adjacent to the oxyl groups, and since they exhibit C2 symmetry they are well suited for coordination chemistry studies because stereochemical complexity is minimized. They have been specifically designed for further developments of the metal-radical approach to molecular magnetic materials. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)
Published: 2005
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28. ChemInform Abstract: Synthetic Approaches to Asymmetric Phthalocyanines and Their Analogues

Author: Ayşe Gül Gürek, Catherine Hirel, Victor N. Nemykin, Semyon V. Dudkin, Fabienne Dumoulin, and Vefa Ahsen
Subjects: Phthalonitrile, chemistry.chemical_compound, chemistry, Component (thermodynamics), Condensation, General Medicine, Combinatorial chemistry
Abstract: This review summarizes synthetic strategies for the preparation of asymmetric phthalocyanines and their analogues. Cross-condensation between two phthalonitrile components, cross- condensation between one phthalonitrile and one non-nitrile component, targeted synthesis of AABB-type compounds, the subphthalocyanine ring-expansion method, as well as post- modification approaches on pre-formed symmetric and asymmetric systems, are discussed. Methodologies for targeted preparation of specific types of asymmetric phthalocyanines and their analogues are also briefly overviewed.
Published: 2015
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29. Bromine-Lithium Exchange As A Straightforward Method To Obtain Meso-Tetrakis(4-Formylphenyl)Porphyrin: A Versatile Intermediate

Author: Emel Önal, Vefa Ahsen, Jacques Pécaut, Dominique Luneau, Catherine Hirel, Laboratoire des Multimatériaux et Interfaces (LMI), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Department of chemistry - Gebze Technical University, Gebze Teknik Üniversitesi [Gebze], Service de Chimie Inorganique et Biologique (SCIB - UMR E3), Institut Nanosciences et Cryogénie (INAC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Centre National de la Recherche Scientifique (CNRS), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), and Université Grenoble Alpes (UGA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)
Subjects: [PHYS]Physics [physics], Bromine, Bouveault reaction, Organic Chemistry, Bromine-lithium exchange, chemistry.chemical_element, Photochemistry, Biochemistry, Porphyrin, Formyl group, chemistry.chemical_compound, chemistry, Sensitized Solar-Cells, Drug Discovery, Functional group, [CHIM]Chemical Sciences, Lithium, Single crystal, ComputingMilieux_MISCELLANEOUS
Abstract: International audience; A three step, one-pot reaction has been developed for the introduction of the formyl functional group to the mesa position of porphyrins. Symmetric meso-tetrakis(4-formylphenyl)porphyrin ((CHO)(4)TPPH2), an important cornerstone in porphyrin chemistry, was obtained selectively in good yields via bromine-lithium exchange and subsequent Bouveault reaction. The meso-tetrakis(4-formylphenyl)porphyrin was fully characterized by HR-ESI, UV-vis, NMR, and single crystal X-ray diffraction. (C) 2015 Elsevier Ltd. All rights reserved.
Published: 2015
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30. Expeditious selective access to functionalized platforms of A7B-type heteroleptic lanthanide double-decker complexes of phthalocyanine

Author: Florian Albrieux, Ayşe Gül Gürek, Catherine Hirel, Vefa Ahsen, Yann Bretonnière, Serkan Alpugan, Ümit İşci, Fabienne Dumoulin, Department of chemistry - Gebze Technical University, Gebze Teknik Üniversitesi [Gebze], Institut de Chimie et Biochimie Moléculaires et Supramoléculaires (ICBMS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-École Supérieure de Chimie Physique Électronique de Lyon (CPE)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Chimie - UMR5182 (LC), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-École Supérieure Chimie Physique Électronique de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-École normale supérieure - Lyon (ENS Lyon)-Institut de Chimie du CNRS (INC)
Subjects: Lanthanide, [CHIM.ORGA]Chemical Sciences/Organic chemistry, Metals and Alloys, chemistry.chemical_element, General Chemistry, [CHIM.CATA]Chemical Sciences/Catalysis, [CHIM.MATE]Chemical Sciences/Material chemistry, [CHIM.INOR]Chemical Sciences/Inorganic chemistry, Photochemistry, Catalysis, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, chemistry.chemical_compound, chemistry, Polymer chemistry, Materials Chemistry, Ceramics and Composites, Phthalocyanine, Europium, Double decker
Abstract: International audience; A one-step method to access to functionalized heteroleptic lanthanide double-decker complexes of phthalocyanine of A7B-type is reported. This optimized statistical method led to two hydroxylated model europium complexes, one of which was further converted into its mesylated and azido derivatives.
Published: 2014
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31. Nitronyl and Imino Nitroxides: Improvement of Ullman's Procedure and Report on a New Efficient Synthetic Route

Author: Kira E. Vostrikova, Victor I. Ovcharenko, Catherine Hirel, Jacques Pécaut, and Paul Rey
Subjects: S-procedure, Nitroxide mediated radical polymerization, Chemistry, Yield (chemistry), Organic Chemistry, Organic chemistry, Free base, General Chemistry, Crystal structure, Imidazolidines, Ring (chemistry), Combinatorial chemistry, Catalysis
Abstract: The synthesis of nitronyl and imino nitroxides has been reexamined with the aim of both increasing yields and of offering opportunities for new structures. The conditions for the formation of 2,3-bis(hydroxyamino)-2,3-dimethylbutane, the key intermediate of Ullman's route, have been carefully studied, and a new procedure is proposed, which affords the free base in a very pure form and up to 60% yield. Full characterization of this intermediate including an X-ray crystal structure is presented. An alternative synthetic route through 2,3-diamino-2,3-dimethylbutane and the corresponding imidazolidines which bypasses the delicate synthesis of the bis(hydroxyamino) compound is described. It is shown that 3-chloroperbenzoic acid is an effective oxidant for the transformation of adequately substituted imidazolidines into nitronyl nitroxides, which are obtained in high yield. An illustration of the potentialities of this new route, a new nitronyl nitroxide with two ethyl substituents in positions 4 and 5 of the imidazoline ring, is reported. The scope and limitations of the two routes are discussed.
Published: 2001
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32. pH-induced 'off-on-off' type molecular switch behaviors of zinc and free tetraimidazophthalocyanines

Author: Emel Önal, Ayşe Gül Gürek, Catherine Hirel, and Sevinc Zehra Topal
Subjects: Inorganic Chemistry, Molecular switch, chemistry.chemical_compound, Deprotonation, chemistry, Imidazole, Molecule, chemistry.chemical_element, Protonation, Zinc, Absorption (chemistry), Photochemistry, Fluorescence
Abstract: Herein, the design and synthesis of pH sensing fluorophores, zinc(II) tetraimidazophthalocyanine (Pc-1) and metal free tetraimidazophthalocyanine (Pc-2), which present “off–on–off” type molecular switches were described. Their pH sensing properties have been investigated in detail in dimethylsulfoxide in the pH range of 2.0–15.0. The respective three forms of the molecules: deprotonated, neutral and protonated, were characterized by absorption and emission spectra as well as apparent pKa values (Pc-1: pKa1 = 5.2 and pKa2 = 14.3, Pc-2: pKa1 = 4.9 and pKa2 = 13.8). The protonation/deprotonation stages of imidazole groups of Pc-1 and Pc-2 present fluorescence-based “off–on–off” type molecular switch properties.
Published: 2013

33. Significant sensitivity and stability enhancement of tetraphenylporphyrin-based optical oxygen sensing material in presence of perfluorochemicals

Author: Emel Önal, Sevinc Zehra Topal, Kadriye Ertekin, Ozlem Oter, Ayşe G. Gürek, and Catherine Hirel
Subjects: Detection limit, chemistry.chemical_compound, Ethyl cellulose, Chemistry, Tetraphenylporphyrin, Analytical chemistry, chemistry.chemical_element, Molecule, General Chemistry, Polystyrene, Luminescence, Fluorescence, Oxygen
Abstract: Emission-based oxygen sensing properties of highly luminescent tetraphenylporphyrin molecules were investigated in polystyrene, ethyl cellulose, poly(1-trimethylsilyl-1-propyne) and poly(isobutylmethacrylate) matrices. The effect of perfluorochemicals (PFCs) on oxygen sensitivity and stability of the sensor materials was also examined. Fluorescence intensity and lifetime measurements of meso-tetraphenylporphyrinato Zn ( II ) (ZnTPP) and meso-tetraphenylporphyrin (H2TPP) materials were performed in the concentration range of 0–100% pO 2. The fluorescence intensity variation of H2TPPvs. oxygen was 86%. H2TPP-based composite also yielded higher Stern–Volmer constant, faster response and regeneration time, excellent long term photostability and larger linear response range with respect to ZnTPP. The detection limit of oxygen for H2TPP was less than 0.5%. When stored in sealed bags protected from sunlight, no decrease in oxygen sensitivity was observed during approximately five months. As far as we know, the gathered utilization of PFCs and H2TPP embedded in polymer matrices was not previously described in literature, and has present amelioration compared to materials already existing.
Published: 2013

34. Photophysical Properties And Study Of The Singlet Oxygen Generation Of Tetraphenylporphyrinato Palladium(Ii) Complexes

Author: Pinar Sen, Yann Bretonnière, Mikael Lindgren, Chantal Andraud, Ayşe Gül Gürek, Catherine Hirel, Dynamique des interactions membranaires normales et pathologiques (DIMNP), Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Chimie - UMR5182 (LC), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-École normale supérieure - Lyon (ENS Lyon)-Institut de Chimie du CNRS (INC)
Subjects: Absorption spectroscopy, Singlet oxygen, [CHIM.ORGA]Chemical Sciences/Organic chemistry, chemistry.chemical_element, 02 engineering and technology, General Chemistry, [CHIM.CATA]Chemical Sciences/Catalysis, [CHIM.MATE]Chemical Sciences/Material chemistry, [CHIM.INOR]Chemical Sciences/Inorganic chemistry, 010402 general chemistry, 021001 nanoscience & nanotechnology, Photochemistry, 01 natural sciences, Oxygen, 0104 chemical sciences, chemistry.chemical_compound, chemistry, Singlet fission, Quantum efficiency, Triplet state, 0210 nano-technology, Luminescence, Phosphorescence, ComputingMilieux_MISCELLANEOUS
Abstract: Three differently substituted Pd-tetraphenyl-porphyrins complexes were synthesized and their X-ray crystal and photophysical properties were studied. All compounds display intense phosphorescence in de-aerated solutions at room temperature with decay time in the μs range. An efficient spin transfer to oxygen in aerated solutions was monitored using singlet oxygen (1 O 2) luminescence at 1275 nm. For all compounds, the quantum efficiency for generating singlet oxygen was found to be close to unity. Interesting differences in the pathways from the excited singlet state to singlet oxygen via the intermediate triplet state were observed. The excitation spectra obtained while recording the phosphorescence at 1275 nm closely matched the absorption spectra with two bands: the Soret (or B) band near 410–420 nm and a split Q-band at 510–520 nm. Noticeable differences in the B/Q intensity ratio between the absorption and excitation spectra (for both phosphorescence and singlet oxygen luminescence) were determined, indicating different Sx → T1 pathways.
Published: 2013
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35. Abab Homoleptic Bis(Phthalocyaninato)Lutetium(Iii) Complex: Toward The Real Octupolar Cube And Giant Quadratic Hyperpolarizability

Author: Isabelle Ledoux-Rak, Vefa Ahsen, Ayşe Gül Gürek, Mehmet Menaf Ayhan, Chantal Andraud, Erwann Jeanneau, Yann Bretonnière, Joseph Zyss, Catherine Hirel, Anu Singh, Laboratoire de Chimie - UMR5182 (LC), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-École normale supérieure - Lyon (ENS Lyon)-Institut de Chimie du CNRS (INC), Laboratoire Traitement et Communication de l'Information (LTCI), Télécom ParisTech-Institut Mines-Télécom [Paris] (IMT)-Centre National de la Recherche Scientifique (CNRS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon, Laboratoire de Photonique Quantique et Moléculaire (LPQM), École normale supérieure - Cachan (ENS Cachan)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS), France Telecom, Centre National d'Etudes de Télécommunications, Laboratoire de Bagneux (CNET Bagneux), CNET, École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Models, Molecular, chemistry.chemical_element, Hyperpolarizability, Crystal structure, [CHIM.INOR]Chemical Sciences/Inorganic chemistry, Crystallography, X-Ray, 010402 general chemistry, Photochemistry, 01 natural sciences, Biochemistry, Catalysis, chemistry.chemical_compound, Colloid and Surface Chemistry, Organometallic Compounds, Molecule, Homoleptic, ComputingMilieux_MISCELLANEOUS, Molecular Structure, 010405 organic chemistry, [CHIM.ORGA]Chemical Sciences/Organic chemistry, General Chemistry, [CHIM.CATA]Chemical Sciences/Catalysis, [CHIM.MATE]Chemical Sciences/Material chemistry, Acceptor, Lutetium, 0104 chemical sciences, Crystallography, chemistry, Phthalocyanine, Cube
Abstract: The concept of octupolar molecules has considerably enlarged the engineering of second-order nonlinear optical materials by giving access to 2D and 3D architectures. However, if the archetype of octupolar symmetry is a cube with alternating donor and acceptor groups at the corners, no translation of this ideal structure into a real molecule has been realized to date. This may be achieved by designing a bis(phthalocyaninato)lutetium(III) double-decker complex with a crosswise ABAB phthalocyanine bearing alternating electron-donor and electron-acceptor groups. In this communication, we present the first step toward this goal with the synthesis, crystal structure determination, and measurement of the molecular first-order hyperpolarizability beta by harmonic light diffusion, of an original lutetium(III) sandwich complex displaying the required ABAB-type alternation for one face of the cube. This structure is characterized by an intense absorption in the near-IR due to an intervalence transition and exhibits the highest quadratic hyperpolarizability ever reported for an octupolar molecule, root )(HLS)(1907) = 5750 X 10(-30) esu.
Published: 2012
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36. Recent Developments of Synthetic Techniques for Porphyrins, Phthalocyanines and Related Systems

Author: Catherine Hirel and Ayşe Gül Gürek
Subjects: Reaction conditions, chemistry.chemical_compound, Materials science, chemistry, Computational chemistry, Ionic liquid
Abstract: This chapter surveys two methods recently developed for the synthesis of porphyrins, phthalocyanines and related compounds: (i) microwave-assisted synthesis and (ii) the use of ionic liquids instead of conventional solvents. These two techniques, that can even be combined, offer several advantages such an increase in the yields and shorter reaction times when compared to the classical reaction conditions.
Published: 2011
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37. Fluorescence and FTIR Spectra Analysis of Trans-A(2)B(2)-Substituted Di- and Tetra-Phenyl Porphyrins

Author: Mikael Lindgren, Catherine Hirel, Christophe Aronica, Hans Ågren, Yann Bretonnière, Boris F. Minaev, Abdelsalam Mohammed, Gleb V. Baryshnikov, Hung-Hsun Lee, Pinar Sen, Chantal Andraud, Julien Duboisset, Valentina A. Minaeva, Department of chemistry - Gebze Technical University, Gebze Teknik Üniversitesi [Gebze], Laboratoire de Chimie - UMR5182 (LC), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-École normale supérieure - Lyon (ENS Lyon)-Institut de Chimie du CNRS (INC), Royal Institute of Technology [Stockholm] (KTH ), The Bohdan Khmelnytsky National University of Cherkasy (BKNUC), Linköpings universitet, Norwegian University of Science and Technology [Trondheim] (NTNU), Norwegian University of Science and Technology (NTNU), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Absorption spectroscopy, 02 engineering and technology, Electronic structure, 010402 general chemistry, Photochemistry, 01 natural sciences, lcsh:Technology, Article, chemistry.chemical_compound, Materialteknik, TD DFT, General Materials Science, Emission spectrum, lcsh:Microscopy, lcsh:QC120-168.85, asymmetric substitution, lcsh:QH201-278.5, Chemistry, lcsh:T, [CHIM.ORGA]Chemical Sciences/Organic chemistry, tetraphenyl porphyrin, [CHIM.MATE]Chemical Sciences/Material chemistry, Materials Engineering, 021001 nanoscience & nanotechnology, electronic structure, Porphyrin, 0104 chemical sciences, Crystallography, FTIR, lcsh:TA1-2040, Molecular vibration, Excited state, Hypsochromic shift, Density functional theory, lcsh:Descriptive and experimental mechanics, lcsh:Electrical engineering. Electronics. Nuclear engineering, fluorescence, 0210 nano-technology, lcsh:Engineering (General). Civil engineering (General), lcsh:TK1-9971
Abstract: International audience; A series of asymmetrically substituted free-base di- and tetra-phenylporphyrins and the associated Zn-phenylporphyrins were synthesized and studied by X-ray diffraction, NMR, infrared, electronic absorption spectra, as well as fluorescence emission spectroscopy, along with theoretical simulations of the electronic and vibration structures. The synthesis selectively afforded trans-A2B2 porphyrins, without scrambling observed, where the AA and BB were taken as donor- and acceptor-substituted phenyl groups. The combined results point to similar properties to symmetrically substituted porphyrins reported in the literature. The differences in FTIR and fluorescence were analyzed by means of detailed density functional theory (DFT) calculations. The X-ray diffraction analysis for single crystals of zinc-containing porphyrins revealed small deviations from planarity for the porphyrin core in perfect agreement with the DFT optimized structures. All calculated vibrational modes (2162 modes for all six compounds studied) were found and fully characterized and assigned to the observed FTIR spectra. The most intense IR bands are discussed in connection with the generic similarity and differences of calculated normal modes. Absorption spectra of all compounds in the UV and visible regions show the typical ethio type feature of meso-tetraarylporphyrins with a very intense Soret band and weak Q bands of decreasing intensity. In diphenyl derivatives, the presence of only two phenyl rings causes a pronounced hypsochromic shift of all bands in the absorption spectra. Time-dependent DFT calculations revealed some peculiarities in the electronic excited states structure and connected them with vibronic bands in the absorption and fluorescence spectra from associated vibrational sublevels.
Published: 2010
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38. Tetraimidazophthalocyanines: Influence Of Protonation And Aggregation On Spectroscopic Observations

Author: Fabienne Dumoulin, Catherine Hirel, and Emel Önal
Subjects: Benzimidazole, chemistry.chemical_compound, chemistry, Rosenmund–von Braun reaction, Diamine, Synthon, Substituent, Molecule, Organic chemistry, Protonation, General Chemistry, Ring (chemistry), Medicinal chemistry
Abstract: The synthesis and spectroscopic characterization of tetraimidazophthalocyanines are presented. This kind of molecules have not been intensively studied due to difficulty in (i) obtaining an easily obtainable synthon: a benzimidazole ring with a variety of substituent, and (ii) achieving the Rosenmund-Von Braun reaction with good yields. The synthesis of novel 2-substituted-5,6-dicyanobenzimidazoles (4a–e) achieved from 4,5-dibromo-N,N'-diacetylated-1,2-phenylene diamine (2a–e) or 2-substituted-5,6-dibromobenzimidazole (3a–e) were optimized. Depending on the starting compound, the reaction could be done according to a two-step pathway (cyclization followed by nitrilation) or a one-pot procedure using microwave irradiation. The target compounds, tetraimidazophthalocyanines (ImiPc(M)) (5a–e;6a–d), were prepared. The effect of the four imidazoles introduced in the phthalocyanines core were compared and discussed.
Published: 2009

39. The cyano nitronyl nitroxide radical: experimental and theoretical evidence for the fourth case of the McConnell-I mechanism

Author: Guillaume Bussière, Jacques Pécaut, Christian Reber, Catherine Hirel, Lars Öhrström, and Dominique Luneau
Subjects: Nitroxide mediated radical polymerization, education.field_of_study, Chemistry, Organic Chemistry, Population, General Chemistry, Crystal structure, Magnetic susceptibility, Catalysis, Crystallography, Tetragonal crystal system, Atomic orbital, Computational chemistry, Antiferromagnetism, Spin (physics), education
Abstract: The nitronyl nitroxide 2-cyano-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide (1) crystallises in the tetragonal P (4) over bar2(1)m space group with a = 7.4050(7), c = 8.649(1) Angstrom. In the crystal the molecules form layers parallel to the ab plane in which they are orthogonal to each other. In the layers there are close contacts, 2.953(2) Angstrom, between the NO groups and the bridging carbon atoms of the O-N-C-N-O fragment of neighbouring radicals. The calculated spin density shows a positive population mainly and equally localised on the NO groups and small but significant negative spin densities on the bridging carbon atom and the cyano nitrogen. Absorption spectra show temperature-dependent transitions related to the magnetic behaviour. The temperature dependence of the magnetic susceptibility in the range 2-300 K reveals that couplings between the radicals are antiferromagnetic, and is interpreted by considering a two-dimensional square array of spin S = 1/2 antiferromagnetically coupled (J = -10 cm(-1) and g = 2.01). This is interpreted as an exchange coupling through close contact between positive and negative spin densities in orthogonal orbitals on oxygen and carbon atoms, respectively.
Published: 2002

40. New Benzimidazole Nitronyl Nitroxides As Electro-Active Compounds for Battery Electrodes

Author: Sevda Akay, Burak Esat, Ismail Fidan, Catherine Hirel, and Natia Frank
Abstract: Battery systems are energy sources in wide scope of applications such as mobile phones, portable computers, uninterruptible power supplies. Radical bearing organic polymers, also called radical polymers, may be used as cathode- or anode-active materials in batteries. TEMPO (2,2,6,6-Tetramethylpiperidin-1-yl-oxyl) bearing polymers have been synthesized and studied as electrode materials for rechargeable batteries1. In a similar way, benzimidazole nitronyl nitroxides (BNNs) which are nitroxide-containing organic molecules like TEMPO can also be utilized as electro-active materials. Our studies involving synthesis and utilization of these molecules as cathode or anode materials in Li-ion batteries will be presented. References 1. A Y. Liang , Z. Tao , J.Chen, Adv. Energy Mater. 2012, 2, 742–769.
Published: 2014
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41. Optimized synthesis and crystal growth by sublimation of 1,3,3-trichloroisoindolenines, key building blocks for crosswise phthalocyanines

Author: Fabienne Dumoulin, Catherine Hirel, Özlem Gökdemir, Ayşe Gül Gürek, Yunus Zorlu, Vefa Ahsen, and Mehmet Menaf Ayhan
Subjects: Crystallography, Materials science, law, Organic chemistry, General Materials Science, Sublimation (phase transition), Crystal growth, General Chemistry, Crystallization, Condensed Matter Physics, law.invention
Abstract: Among possible asymmetrically substituted phthalocyanines, ABAB derivatives remain rare. Their selective synthesis is based on the use of trichloroisoindolenines, so far remaining tedious to obtain. An optimized synthesis of 1,3,3-trichloroisoindolenine 1 and 1,3,3,6,7-pentachloroisoindolenine 2 is reported. An original crystallization method based on crystal growth by sublimation was eminently suitable regarding the air-sensitivity of these derivatives and allowed their thorough crystallographic characterization.
Published: 2014
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42. Modulation of the electronic and spectroscopic properties of Zn(ii) phthalocyanines by their substitution pattern

Author: Ümit İşci, Savas Berber, Ayşe G. Gürek, Ufuk Kumru, Jean-Bernard Tommasino, Vefa Ahsen, Sevinc Zehra Topal, Devrim Atilla, Dominique Luneau, Catherine Hirel, Mahmut Durmuş, Fabienne Dumoulin, Department of chemistry - Gebze Technical University, Gebze Teknik Üniversitesi [Gebze], Laboratoire des Multimatériaux et Interfaces (LMI), Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Stereochemistry, Substitution (logic), Substituent, chemistry.chemical_element, [CHIM.MATE]Chemical Sciences/Material chemistry, Electron, Zinc, Inorganic Chemistry, Crystallography, chemistry.chemical_compound, chemistry, Modulation, Atom, [CHIM]Chemical Sciences
Abstract: International audience; Four isomerically pure octasubstituted zinc phthalocyanines with variations in the attachment atom and positions of the substituents were selected for a systematic investigation of the effect of the substitution pattern on their electronic and spectroscopic properties. Effects which were investigated are the position, the electron donating and withdrawing properties, and the donating force of the substituent. The results are discussed and interpreted based on theoretical and experimental determination of the orbital levels. This work allows us to highlight which substitution patterns are the most suitable considering different common applications of phthalocyanines.
Published: 2014
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43. Impact of Lower Versus Higher LDL Cholesterol Targets on Cardiovascular Events After Ischemic Stroke in Patients With Diabetes

Author: Pierre, Amarenco, Jong S, Kim, Julien, Labreuche, Hugo, Charles, Maurice, Giroud, Byung-Chul, Lee, Philippa C, Lavallée, Marie-Hélène, Mahagne, Elena, Meseguer, Norbert, Nighoghossian, Philippe Gabriel, Steg, Éric, Vicaut, Eric, Bruckert, Jongwon, Chung, Laboratoire de Recherche Vasculaire Translationnelle (LVTS (UMR_S_1148 / U1148)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Université Sorbonne Paris Nord, Asan Medical Center [Seoul, South Korea] (AMC), Santé Publique : épidémiologie et qualité des soins (EA 2694), Université Lille 2 - Faculté de Médecine -Centre d'Etudes et de Recherche en Informatique Médicale [Lille] (CERIM), Physiopathologie et épidémiologie cérébro-cardiovasculaire [Dijon] (PEC2), Université de Bourgogne (UB)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Hallym University Sacred Heart Hospital [Anyang, South Korea] (HUS2H), Hôpital Pasteur [Nice] (CHU), Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Hospices Civils de Lyon (HCL), Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Treat Stroke to Target Investigators, Treat Stroke to Target investigators: Pierre Amarenco, Eric Bruckert, Maurice Giroud, Jong S Kim, Julien Labreuche, Byung-Chul Lee, Marie-Hélène Mahagne, Norbert Nighoghossian, Philippe Gabriel Steg, Pierre-Jean Touboul, Eric Vicaut, Didier Leys, Yannick Béjot, Philippa Lavallée, Fernando Pico, Emmanuel Touzé, Gregory Ducrocq, Jérémy Abtan, Olivier Varenne, Charles Foix, Agnes Kemmel, Fausta Syana, Manele Ledra, Tharani Nagasara, Mervette Ledjeroud, Bahous Samia, Hafirassou Hadia, Benyoub Hazare, Ikrame El Jaghouni, Nessima Yelles, Sofia Zemouri, Salim Kerai, YunJeong In, Elena Meseguer, Philippa C Lavallée, Cristina Hobeanu, Celine Guidoux, Lucie Cabrejo, Bertrand Lapergue, Candice Sabben, Jaime Gonzalez-Valcarcel, Ricardo Rigual, Gaia Sirimarco, Anna Martin-Bechet, Elena Viedma, Ioan Avram, Yves Samson, Charlotte Rosso, Sophie Crozier, Sara Leder, Anne Léger, Sandrine Deltour, Gurkan Mutlu, Marion Yger, Chiara Zavanone, Flore Baronnet, Christine Pires, Bertrand Lapergue, Adrien Wang, Serge Evrard, Maya Tchikviladze, Frédéric Bourdain, Delphine Lopez, Fernando Pico, Laetitia Bayon de la Tour, Marie-Laure Chadenat, Duc Long Duong, Solène Genty, Catherine Hirel, Chantal Nifle, Jérôme Servan, Daniela Stanciu, Veronica Sudacevschi, Mélissa Tir, Anne-Cécile Troussière, Jennifer Yeung, Anne-Céline Zeghoudi, Ikram Tidafi-Bayou, Sylvain Lachaud, Tae-Hee Cho, Laura Mechtouff, Thomas Ritzenthaller, Laurent Derex, Carlo Albanesi, Elodie Ong, Amandine Benoit, Nadia Berhoune, Sandra Felix, Maud Esteban-Mader, Igor Sibon, Annabelle Kazadi, François Rouanet, Pauline Renou, Sabrina Debruxelles, Mathilde Poli, Sharmila Sagnier, Jean-Louis Mas, Valérie Domigo, Catherine Lamy, Eric Bodiguel, Jérôme Grimaud, Valentin Bohotin, Michael Obadia, Erwan Morvan, Gilles Rodier, Wilfried Vadot, Hilde Hénon, Charlotte Cordonnier, Frédéric Dumont, Marie Bodenant, Christian Lucas, Solène Moulin, Nelly Dequatre, Sonia Alamowitch, Jean-Paul Muresan, Thomas Drouet, Magalie Gallea, Marie-Amélie Dalloz, Stephen Delorme, Marion Yger, Yannick Béjot, Philippe Loisel, Carine Bonnin, Virginie Bernigal, Guy Victor Osseby, Marie Hervieu-Bègue Marsac, Pierre Garnier, Sandrine Accassat, Magali Epinat, Jérôme Varvat, Doïna Marinescu, Aude Triquenot-Bagan, Ozlem Ozkul-Wermester, Frédéric Philippeau, Angel Olaru, Anne Vieillart, Annie Lannuzel, Alice Demoly, Valérie Wolff, Mihaela Diaconu, Marc Bataillard, Francisco Macian Montoro, Frédéric Faugeras, Laeticia Gimenez, Françoise Abdallah-Lebeau, Serge Timsit, Irina Viakhireva-Dovganyuk, Anne Tirel-Badets, François-Mathias Merrien, Philippe Goas, François Rouhart, Aurore Jourdain, Benoit Guillon, Fanny Hérissson, Mathieu Sevin-Allouet, Nathalie Nasr, Jean-Marc Olivot, Alderic Lecluse, Guillaume Marc, Marie Christine Hamon, Emmanuel Touzé, Vincent de la Sayette, Marion Apoil, Li Lin, Julien Cogez, Sophie Guettier, Olivier Godefroy, Jean-Marc Bugnicourt, Grégory Taurin, Marc Mérienne, Julien Gere, Anne-Marie Chessak, Tarik Habet, Anna Ferrier, Nathalie Bourgois, Dominique Minier, Marie Caillier-Minier, Fabienne Contégal-Callier, Philippe Vion, Yvan Vaschalde, Mohammed El Amrani, Emilie Xxx, Mathieu Zuber, Marie Bruandet, Claire Join-Lambert, Pierre-Yves Garcia, Isabelle Serre, Jean-Marc Faucheux, Fatia Radji, Elena Leca-Radu, Thomas Debroucker, Rodica Cumurcuc, Serkan Cakmak, Stéphane Peysson, Emmanuel Ellie, Patricia Bernady, Thierry Moulin, Paola Montiel, Eugeniu Revenco, Pierre Decavel, Elisabeth Medeiros, Myriam Bouveret, Pierre Louchart, Jean-Philippe Neau, Xavier Vandamme, Isabelle Meresse, Xxx Stantescu, Canan Ozsancak, Katell Beauvais, Pascal Auzou, Joséphine Amevigbe, Francis Vuillemet, Marie-Hélène Dugay-Arentz, Gabriela Carelli, Mikel Martinez, Marcel Maillet-Vioud, Jean-Pierre Escaillas, Stéphane Chapuis, Jean Tardy, Eric Manchon, Olivier Varnet, Yong-Jae Kim, Yoonkyung Chang, Tae-Jin Song, Jong Sung Kim, Jung-Hoon Han, Kyung Chul Noh, Eun-Jae Lee, Dong-Wha Kang, Sun Uck Kwon, Boseoung Kwon, Seongho Park, Dongwhane Lee, Hyuk Sung Kwon, Daeun Jeong, MinHwan Lee, Joonggoo Kim, Hanbin Lee, Hyo Jung Nam, Sang Hun Lee, Bum Joon Kim, Jae-Kwan Cha, DaeHyun Kim, Rae Young Kim, Sang Wuk Sohn, Dong-Hyun Shim, Hyungjin Lee, Hyun-Wook Nah, Sang Min Sung, Kyung Bok Lee, Jeong Yoon Lee, Jee Eun Yoon, Eung-Gyu Kim, Jung Hwa Seo, Yong-Won Kim, Yangha Hwang, Man Seok Park, Joon-Tae Kim, Kang-Ho Choi, Hyo Suk Nam, Ji Hoe Heo, Young Dae Kim, In Gun Hwang, Hyung Jong Park, Kyoung Sub Kim, Jang Hyun Baek, Dong Beom Song, Joon Sang Yoo, Jong-Moo Park, Ohyun Kwon, Woong-Woo Lee, Jung-Ju Lee, Kyusik Kang, Byung Kun Kim, Byung-Chul Lee, Jae-Sung Lim, Mi Sun Oh, Kyung-Ho Yu, Bora Hong, Mihoon Jang, Seyoung Jang, Jung Eun Jin, Jei Kim, Hye Seon Jeong, Keun Sik Hong, Hong Kyun Park, Yong Jin Cho, Oh Young Bang, Woo-Keun Seo, Jongwon Chung., Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, Faculté de Médecine Henri Warembourg - Université de Lille-Centre d'Etudes et de Recherche en Informatique Médicale [Lille] (CERIM), and CarMeN, laboratoire
Subjects: Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, [SDV]Life Sciences [q-bio], Hypercholesterolemia, Myocardial Infarction, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Text mining, Internal medicine, Diabetes mellitus, Internal Medicine, Medicine, Humans, In patient, cardiovascular diseases, Aged, Ischemic Stroke, Ldl cholesterol, business.industry, Cholesterol, LDL, Middle Aged, medicine.disease, Ezetimibe, 3. Good health, [SDV] Life Sciences [q-bio], Treatment Outcome, Diabetes Mellitus, Type 2, Ischemic stroke, Cardiology, lipids (amino acids, peptides, and proteins), Female, Hydroxymethylglutaryl-CoA Reductase Inhibitors, business, 030217 neurology & neurosurgery
Abstract: International audience; After an ischemic stroke with evidence of atherosclerosis, lipid-lowering treatment with a target LDL cholesterol of
Published: 2021
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44. A Comparison of Two LDL Cholesterol Targets after Ischemic Stroke

Author: Amarenco P, Kim J, Labreuche J, Charles H, Abtan J, Bejot Y, Cabrejo L, Cha J, Ducrocq G, Giroud M, Guidoux C, Hobeanu C, Kim Y, Lapergue B, Lavallee P, Lee B, Lee K, Leys D, Mahagne M, Meseguer E, Nighoghossian N, Pico F, Samson Y, Sibon I, Steg P, Sung S, Touboul P, Touze E, Varenne O, Vicaut E, Yelles N, Bruckert E, Treat Stroke Target Investigators, AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Asan Medical Center [Seoul], University of Ulsan, Santé Publique : épidémiologie et qualité des soins (EA 2694), Faculté de Médecine Henri Warembourg - Université de Lille-Centre d'Etudes et de Recherche en Informatique Médicale [Lille] (CERIM), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Université de Bourgogne (UB), Service de neurologie [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU), Catholic University of Korea, Hôpital Foch [Suresnes], Hallym University Sacred Heart Hospital [Anyang, South Korea] (HUS2H), Soonchunhyang University [Asan], CHU Lille, Hôpital Pasteur [Nice] (CHU), Hospices Civils de Lyon (HCL), Centre Hospitalier de Versailles André Mignot (CHV), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Sorbonne Université (SU), Hôpital Pellegrin, CHU Bordeaux [Bordeaux]-Groupe hospitalier Pellegrin, Pusan National University Hospital, Physiopathologie et imagerie des troubles neurologiques (PhIND), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Neurologie [CHU Caen], Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), GIP Cyceron (Cyceron), Normandie Université (NU)-Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service de Cardiologie [CHU Cochin], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Laboratoire de Recherche Vasculaire Translationnelle (LVTS (UMR_S_1148 / U1148)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, Hôpitaux Universitaire Saint-Louis, Lariboisière, Fernand-Widal, Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition [CHU Pitié Salpêtrière] (IHU ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Pitié-Salpêtrière [AP-HP], Laboratoire de Neurosciences Fonctionnelles et Pathologies - UR UPJV 4559 (LNFP), Université de Picardie Jules Verne (UPJV), CHU Amiens-Picardie, and Treat Stroke to Target Investigators: Pierre Amarenco, Eric Bruckert, Maurice Giroud, Jong S Kim, Julien Labreuche, Byung-Chul Lee, Marie-Hélène Mahagne, Norbert Nighoghossian, Philippe Gabriel Steg, Pierre-Jean Touboul, Eric Vicaut, Didier Leys, Philippa Lavallée, Gregory Ducrocq, Jérémy Abtan, Olivier Varenne, Agnes Kemmel, Fausta Syana, Manele Ledra, Tharani Nagasara, Mervette Ledjeroud, Bahous Samia, Hafirassou Hadia, Benyoub Hazare, Ikrame El Jaghouni, Nessima Yelles, Sofia Zemouri, Mervette Ladjeroud, Salim Kerai, YunJeong In, Elena Meseguer, Philippa C Lavallée, Cristina Hobeanu, Celine Guidoux, Lucie Cabrejo, Jaime Gonzalez-Valcarcel, Ricardo Rigual, Gaia Sirimarco, Anna Martin-Bechet, Elena Viedma, Ioan Avram, Yves Samson, Charlotte Rosso, Sophie Crozier, Sara Leder, Anne Léger, Sandrine Deltour, Chiara Zavanone, Flore Baronnet, Christine Pires, Bertrand Lapergue, Adrien Wang, Serge Evrard, Maya Tchikviladze, Frédéric Bourdain, Delphine Lopez, Fernando Pico, Laetitia Bayon de la Tour, Marie-Laure Chadenat, Duc Long Duong, Solène Genty, Catherine Hirel, Gurkan Mutlu, Chantal Nifle, Jérôme Servan, Daniela Stanciu, Veronica Sudacevschi, Mélissa Tir, Anne-Cécile Troussière, Jennifer Yeung, Anne-Céline Zeghoudi, Ikram Tidafi-Bayou, Sylvain Lachaud, Tae-Hee Cho, Laura Mechtouff, Thomas Ritzenthaller, Laurent Derex, Carlo Albanesi, Elodie Ong, Amandine Benoit, Nadia Berhoune, Sandra Felix, Maud Esteban-Mader, Igor Sibon, Annabelle Kazadi, François Rouanet, Pauline Renou, Sabrina Debruxelles, Mathilde Poli, Sharmila Sagnier, Jean-Louis Mas, Valérie Domigo, Catherine Lamy, Eric Bodiguel, Jérôme Grimaud, Valentin Bohotin, Michael Obadia, Candice Sabben, Erwan Morvan, Gilles Rodier, Wilfried Vadot, Hilde Hénon, Charlotte Cordonnier, Frédéric Dumont, Marie Bodenant, Christian Lucas, Solène Moulin, Nelly Dequatre, Sonia Alamowitch, Jean-Paul Muresan, Thomas Drouet, Magalie Gallea, Marie-Amélie Dalloz, Stephen Delorme, Marion Yger, Yannick Béjot, Philippe Loisel, Carine Bonnin, Virginie Bernigal, Guy Victor Osseby, Marie Hervieu-BègueMarsac, Pierre Garnier, Sandrine Accassat, Magali Epinat, Jérôme Varvat, Doïna Marinescu, Aude Triquenot-Bagan, Ozlem Ozkul-Wermester, Frédéric Philippeau, Angel Olaru, Anne Vieillart, Annie Lannuzel, Alice Demoly, Valérie Wolff, Mihaela Diaconu, Francisco Macian Montoro, Frédéric Faugeras, Laeticia Gimenez, Françoise Abdallah-Lebeau, Serge Timsit, Irina Viakhireva-Dovganyuk, Anne Tirel-Badets, François-Mathias Merrien, Philippe Goas, François Rouhart, Aurore Jourdain, Benoit Guillon, Fanny Hérissson, Mathieu Sevin-Allouet, Nathalie Nasr, Jean-Marc Olivot, Alderic Lecluse, Guillaume Marc, Emmanuel Touzé, Vincent de la Sayette, Marion Apoil, Li Lin, Julien Cogez, Sophie Guettier, Olivier Godefroy, Chantal Lamy, Jean-Marc Bugnicourt, Grégory Taurin, Marc Mérienne, Julien Gere, Anne-Marie Chessak, Tarik Habet, Anna Ferrier, Nathalie Bourgois, Dominique Minier, Marie Caillier-Minier, Fabienne Contégal-Callier, Philippe Vion, Yvan Vaschalde, Mohammed El Amrani, Mathieu Zuber, Marie Bruandet, Claire Join-Lambert, Pierre-Yves Garcia, Isabelle Serre, Jean-Marc Faucheux, Fatia Radji, Elena Leca-Radu, Thomas Debroucker, Rodica Cumurcuc, Serkan Cakmak, Stéphane Peysson, Emmanuel Ellie, Patricia Bernady, Thierry Moulin, Paola Montiel, Eugeniu Revenco, Pierre Decavel, Elisabeth Medeiros, Myriam Bouveret, Pierre Louchart, Claudia Vaduva, Grégory Couvreur, Eric Sartori, Adam Amer Alnajar-Carpentier, Michèle Levasseur, Pierre Louchart, Jean-Philippe Neau, Xavier Vandamme, Isabelle Meresse, Marc Bataillard, Canan Ozsancak, Katell Beauvais, Pascal Auzou, Joséphine Amevigbe, Francis Vuillemet, Marie-Hélène Dugay-Arentz, Gabriela Carelli, Mikel Martinez, Marcel Maillet-Vioud, Jean-Pierre Escaillas, Stéphane Chapuis, Jean Tardy, Eric Manchon, Olivier Varnet, Yong-Jae Kim, Yoonkyung Chang, Tae-Jin Song, Jong Sung Kim, Jung-Hoon Han, Kyung Chul Noh, Eun-Jae Lee, Dong-Wha Kang, Sun Uck Kwon, Boseoung Kwon, Seongho Park, Dongwhane Lee, Hyuk Sung Kwon, Daeun Jeong, MinHwan Lee, Joonggoo Kim, Hanbin Lee, Hyo Jung Nam, Sang Hun Lee, Bum Joon Kim, Jae-Kwan Cha, DaeHyun Kim, Rae Young Kim, Sang Wuk Sohn, Dong-Hyun Shim, Hyungjin Lee, Hyun-Wook Nah, Sang Min Sung, Kyung Bok Lee, Jeong Yoon Lee, Jee Eun Yoon, Eung-Gyu Kim, Jung Hwa Seo, Yong-Won Kim, Yangha Hwang, Man Seok Park, Joon-Tae Kim, Kang-Ho Choi, Hyo Suk Nam, Ji Hoe Heo, Young Dae Kim, In Gun Hwang, Hyung Jong Park, Kyoung Sub Kim, Jang Hyun Baek, Dong Beom Song, Joon Sang Yoo, Jong-Moo Park, Ohyun Kwon, Woong-Woo Lee, Jung-Ju Lee, Kyusik Kang, Byung Kun Kim, Jae-Sung Lim, Mi Sun Oh, Kyung-Ho Yu, Bora Hong, Mihoon Jang, Seyoung Jang, Jung Eun Jin, Jei Kim, Hye Seon Jeong, Keun Sik Hong, Hong Kyun Park, Yong Jin Cho, Oh Young Bang, Woo-Keun Seo, Jongwon Chung
Subjects: Adult, Male, medicine.medical_specialty, Statin, medicine.drug_class, [SDV]Life Sciences [q-bio], MEDLINE, Kaplan-Meier Estimate, 030204 cardiovascular system & hematology, Brain Ischemia, law.invention, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Text mining, Pharmacotherapy, Randomized controlled trial, law, Internal medicine, Humans, Medicine, cardiovascular diseases, 030212 general & internal medicine, Aged, Intention-to-treat analysis, business.industry, Cholesterol, Anticholesteremic Agents, Cholesterol, LDL, General Medicine, Middle Aged, Atherosclerosis, Ezetimibe, Intention to Treat Analysis, Stroke, chemistry, Cardiovascular Diseases, Ischemic Attack, Transient, Ischemic stroke, Drug Therapy, Combination, Female, lipids (amino acids, peptides, and proteins), Hydroxymethylglutaryl-CoA Reductase Inhibitors, business
Abstract: International audience; BACKGROUND: The use of intensive lipid-lowering therapy by means of statin medications is recommended after transient ischemic attack (TIA) and ischemic stroke of atherosclerotic origin. The target level for low-density lipoprotein (LDL) cholesterol to reduce cardiovascular events after stroke has not been well studied. METHODS: In this parallel-group trial conducted in France and South Korea, we randomly assigned patients with ischemic stroke in the previous 3 months or a TIA within the previous 15 days to a target LDL cholesterol level of less than 70 mg per deciliter (1.8 mmol per liter) (lower-target group) or to a target range of 90 mg to 110 mg per deciliter (2.3 to 2.8 mmol per liter) (higher-target group). All the patients had evidence of cerebrovascular or coronary-artery atherosclerosis and received a statin, ezetimibe, or both. The composite primary end point of major cardiovascular events included ischemic stroke, myocardial infarction, new symptoms leading to urgent coronary or carotid revascularization, or death from cardiovascular causes. RESULTS: A total of 2860 patients were enrolled and followed for a median of 3.5 years; 1430 were assigned to each LDL cholesterol target group. The mean LDL cholesterol level at baseline was 135 mg per deciliter (3.5 mmol per liter), and the mean achieved LDL cholesterol level was 65 mg per deciliter (1.7 mmol per liter) in the lower-target group and 96 mg per deciliter (2.5 mmol per liter) in the higher-target group. The trial was stopped for administrative reasons after 277 of an anticipated 385 end-point events had occurred. The composite primary end point occurred in 121 patients (8.5%) in the lower-target group and in 156 (10.9%) in the higher-target group (adjusted hazard ratio, 0.78; 95% confidence interval, 0.61 to 0.98; P = 0.04). The incidence of intracranial hemorrhage and newly diagnosed diabetes did not differ significantly between the two groups. CONCLUSIONS: After an ischemic stroke or TIA with evidence of atherosclerosis, patients who had a target LDL cholesterol level of less than 70 mg per deciliter had a lower risk of subsequent cardiovascular events than those who had a target range of 90 mg to 110 mg per deciliter. (Funded by the French Ministry of Health and others; Treat Stroke to Target ClinicalTrials.gov number, NCT01252875.).
Published: 2020
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