Search

Autoimmune-mediated congenital heart block (CHB) is a severe manifestation of neonatal lupus in which conduction tissues of the fetal heart are damaged. This occurs due to passive transference of maternal anti-SSA/Ro and anti-SSB/La autoantibodies and subsequent inflammation and fibrosis of the atrioventricular (AV) node. Notably, the disease manifests after the fetal heart has structurally developed, ruling out other anatomical abnormalities that could otherwise contribute to the block of conduction. Complete AV block is irreversible and the most common manifestation of CHB, although other cardiac complications such as endocardial fibroelastosis (EFE), dilated cardiomyopathy, and valvular insufficiency have been observed. In this review, we detail the classification, prevalence, pathogenesis, and clinical management recommendations for autoimmune CHB.

OBJECTIVE: To examine the prevalence of various types of tobacco-free policies among a US national sample of postsecondary educational institutions (PEIs). PARTICIPANTS: A national sample of US PEIs (N=605) attended by the participants of the NEXT Generation Health Study. METHODS: Tobacco policies of these PEIs were reviewed to determine if they were e-cigarette-free (yes/no), hookah-free (yes/no), and ACHA-recommended tobacco-free (yes/no) in June-December 2017. Logistic regression models were used to examine the relationships between institutional characteristics and tobacco policies. RESULTS: Overall, 39.2%, 26.0%, and 20.0% of the sample adopted e-cigarette-free, hookah-free, and ACHA-recommended tobacco-free policies, respectively. Proprietary PEIs (vs. public) were less likely to have ACHA-recommended tobacco-free policies, while PEIs in the South and Midwest (vs. West) were more likely to have ACHA-recommended tobacco-free policies (p

Objectives. To examine the institutional characteristics associated with the adoption of tobacco- and smoke-free policies among US postsecondary educational institutions. Methods. In 2017, we collected information on tobacco policy types and institutional characteristics of a national sample of US postsecondary educational institutions (n = 605) attended by the participants of the NEXT Generation Health Study. We used logistic regression to examine the relationships between these variables. Results. Overall, 35.2% of these institutions adopted tobacco-free policies (i.e., prohibit all tobacco product use on campus), 10.1% had smoke-free policies (i.e., prohibit smoking but not other tobacco product use on campus), and 53.7% did not have tobacco- or smoke-free policies. Proprietary (privately owned, for-profit) institutions (vs public institutions) were the least likely to have tobacco- or smoke-free policies (P Conclusions. Prevalence of tobacco- and smoke-free policies among US postsecondary educational institutions is low. Public Health Implications. Wide dissemination of evidence-based interventions to accelerate adoption of tobacco-free policies in all postsecondary educational institutions is warranted.

Resumen El artículo analiza el debate sobre neomalthusianismo y eugenesia que se realizó en medios anarquistas españoles en el primer tercio del siglo pasado. Con marcos teóricos poco utilizados hasta la fecha, se aportan nuevas interpretaciones acerca de lo que supuso la utilización del término eugenesia en las revistas neomalthusianas de inspiración anarquista. Enmarcado en una “lucha por el significado”, el neomalthusianismo español resignificó las ideas eugenésicas que tenían como finalidad recuperar el terreno político perdido en la iniciativa por el control individual de la sexualidad humana. Asimismo, se analiza el papel que desempeñó la estrategia de “acción directa” por parte del movimiento anarcosindicalista que consideraba las acciones emprendidas por los anarquistas individualistas como un complemento de su acción revolucionaria. Abstract This article analyzes the debate on neo-Malthusianism and eugenics in Spanish anarchist publications in the first third of the last century. Using theoretical frameworks that have been under-utilized thus far, it provides new interpretations of what the term “eugenics” meant in pro-anarchist neo-Malthusian journals. Framed within a “struggle over meaning,” Spanish neo-Malthusianism re-signified eugenic ideas in an attempt to recover political ground that had been lost in the drive to promote individual control of human sexuality. This study also analyzes the role of the anarcho-syndicalist movement’s “direct action” strategy, in which actions undertaken by individualist anarchists were seen as a complement to revolutionary action.

Background The Accelerating Medicines Partnership (AMP) is a public-private network comprising the National Institutes of Health, medical centers, biopharmaceutical companies and non-profit organizations. The Networks overarching mission is to develop SLE diagnostics and treatments via transcriptomic analysis of cells isolated from renal biopsies. This study addresses the safety of the research component of clinically indicated percutaneous kidney biopsies in anticipation of generalizing these results for real world clinical practice. We focused on one site (NYU METRO) for uniformity of data collection in which all biopsies were done by interventional radiology using an 18 gauge needle. Methods Patients undergoing kidney biopsies to evaluate proteinuria exceeding 500 mg/day (based on uPCR) were consented to donate research tissue which was acquired via an extra pass or the use of a piece of a core with sufficient glomeruli available for both clinical evaluation and research. Adverse events (AE) within 30 days of biopsy were reported. Results 98 patients with sufficient research kidney tissue have enrolled through the three Phases of AMP (0=technical, 1=technical translational, 2=ongoing full follow-up): 10 males, 88 females; 68 Non-Hispanic (69.4%), 30 Hispanic (30.6%); 19 Asian (19.4%), 32 Black (32.7%), 46 White (46.9%), 1 other (1.0%). Biopsy classes varied: 5 non-LN (5.1%), 1 Class I (1.0%), 5 Class II (5.1%), 21 Class III (21.4%), 16 Class IV (16.3%), 15 Class V (15.3%), 20 Class III/V (20.4%), 11 Class IV/V (11.2%), 3 Class VI (3.1%), 1 not yet determined. Research biopsy core lengths ranged from 4–19 mm. Eleven patients had an AE (research biopsy core lengths 5 13 mm); 8 were hematomas (only 6 had an extra pass specific for research). Of the 8 patients, 5 were hospitalized, 4 for the hematoma with 1 receiving a transfusion. Neither number of passes nor research core length predicted hematoma. All hematomas resolved within one week. The remaining 3 AEs were unrelated to the biopsy: 1 cardiac event-related death, 1 UTI, 1 fall. This site-specific frequency is similar to that being observed in the overall multisite ongoing Phase 2 AMP Network. Conclusions Albeit this detailed report is limited to one site, it is consistent with the Network experience. These data support the feasibility and safety of obtaining a research core to bring personalized medicine to the management of LN. Funding Source(s): This work was supported by the Accelerating Medicines Partnership (AMP) in Rheumatoid Arthritis and Lupus Network. AMP is a public-private partnership (AbbVie, Arthritis Foundation, Bristol-Myers Squibb, Foundation for the NIH, Lupus Foundation of America, Lupus Research Alliance, Merck Sharp and Dohme, NIAID, NIAMS, Pfizer, Rheumatology Research Foundation, Sanofi, and Takeda Pharmaceuticals) created to develop new ways of identifying and validating promising biological targets for diagnostics and drug development. Funding was provided through grants from the National Institutes of Health (UH2-AR067676, UH2-AR067677, UH2-AR067679, UH2-AR067681, UH2-AR067685, UH2-AR067688, UH2-AR067689, UH2-AR067690, UH2-AR067691, UH2-AR067694, UM2-AR067678).

A partir du débat sur l'Amazonie aujourd'hui en cours au Brésil, et de recherches directement effectuées dans ses régions orientale et méridionale, un nouveau concept géopolitique de la frontière est proposé. L'Etat et la haute technologie sont les déterminants historiques de la production de la frontière, espace en cours d'incorporation à l'espace global fragmenté, partiellement structuré et doté d'un grand potentiel politique. Les conditions actuelles de la production de la frontière sont principalement : l'appropriation monopoliste de l'espace par diverses fractions du capital ; la mobilité de la force de travail ; les réseaux d'organisation de l'espace et la formation de régions, comprises comme pouvoir local. La résistance des petits producteurs vise la conquête d'un espace propre, s'effectue sous forme de conflits du quotidien et joue un rôle fondamental dans l'orientation du processus de la production de l'espace. (Résumé d'auteur)