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2 results on '"Cathy Sandra Goimelle Coti-Reckoundji"'

1. SARS-CoV-2 Neutralizing Antibodies in Three African Countries Following Multiple Distinct Immune Challenges

Author

Diary Juliannie Ny Mioramalala, Rila Ratovoson, Paul Alain Tagnouokam-Ngoupo, Hermine Abessolo Abessolo, Joseph Marie Mindimi Nkodo, Georges Bouting Mayaka, Pierre Claude Tsoungui Atangana, Fanirisoa Randrianarisaona, Pulchérie Pélembi, Romaric Nzoumbou-Boko, Cathy Sandra Goimelle Coti-Reckoundji, Alexandre Manirakiza, Anjanirina Rahantamalala, Rindra Vatosoa Randremanana, Mathurin Cyrille Tejiokem, and Matthieu Schoenhals

Subjects
neutralizing antibodies, natural infection, vaccination, healthcare worker, COVID-19, Medicine
Abstract

Background: The COVID-19 pandemic has affected Madagascar, Cameroon, and the Central African Republic (CAR), with each experiencing multiple waves by mid-2022. This study aimed to evaluate immunity against SARS-CoV-2 strains Wuhan (W) and BA.2 (BA.2) among healthcare workers (HCWs) in these countries, focusing on vaccination and natural infection effects. Methods: HCWs’ serum samples were analyzed for neutralizing antibodies (nAbs) against W and BA.2 variants, with statistical analyses comparing responses between countries and vaccination statuses. Results: Madagascar showed significantly higher nAb titers against both strains compared to CAR and Cameroon. Vaccination notably increased nAb levels against W by 2.6-fold in CAR and 1.8-fold in Madagascar, and against BA.2 by 1.6-fold in Madagascar and 1.5-fold in CAR. However, in Cameroon, there was no significant difference in nAb levels between vaccinated and unvaccinated groups. Conclusion: This study highlights the complex relationship between natural and vaccine-induced immunity, emphasizing the importance of assessing immunity in regions with varied epidemic experiences and low vaccination rates.

Published
2024
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2. Very high relative seroprevalence of anti-SARS-CoV-2 antibodies among communities in Bangui, Central African Republic

Author

Pr. Emmanuel Nakoune, Brice Martial Yambiyo, Alexandre Manirakiza, Joella Namsenei, Pr. Jean de Dieu Longo, Marie-Astrid Vernet, Jean Baptiste Roungou, Pr. Narcisse Patrice Komas, Modeste Bouhouda, Christian Malaka, Cathy Sandra Goimelle Coti-Reckoundji, Pr. Henri Saint-Calver Diemer, Guy Vernet, Pr. Gérard Grésenguet, and Marie Roseline Darnycka Belizaire

Subjects
History, medicine.medical_specialty, education.field_of_study, Polymers and Plastics, business.industry, Public health, Population, Industrial and Manufacturing Engineering, Herd immunity, Medicine, Seroprevalence, Residence, Cumulative incidence, Business and International Management, business, education, Serostatus, Sex ratio, Demography
Abstract

BackgroundLarge-scale population-based seroprevalence studies of SARS-CoV-2 are essential to characterize the cumulative incidence of SARS-CoV-2 infection and to extrapolate the prevalence of presumptive immunity at the population level.ObjectiveThe objective of our survey was to estimate the cumulative population immunity for COVID-19 and to identify individual characteristics associated with a positive serostatus.MethodThis was a clustered cross-sectional study conducted from July 12 to August 20, 2021, in households in the city of Bangui, the capital of the Central African Republic. Information regarding demographic characteristics (age, gender, and place of residence), comorbidities (chronic diseases) was collected. A venous blood sample was obtained for each participant to determine the level of total anti-SARS-CoV-2 antibodies using a WANTAI SARS-CoV-2 Ab ELISA kit.ResultsAll up, 799 participants were surveyed. The average age was 27 years, and 45·8% of the respondents were male (sex ratio: 0.8). The overall proportion of respondents with a positive serostatus was 74·1%. Participants over 20 years of age were twice as likely to have a positive serostatus, with an OR of 2.· ·2 (95% CI: [1·6, 3·1]).InterpretationThe results of this survey revealed a high cumulative level of immunity in Bangui, thus indicating a significant degree of spread of SARS-CoV-2 in the population. The public health implications of this high level of immunity to SARS-CoV-2, particularly on its variants burden, remain to be determined.FundingThis study was funded by the French Ministry for Europe and Foreign Affairs through the REPAIR COVID-19-Africa project coordinated by the Pasteur International Network association.

Published
2021

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