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Your search keyword '"Catueno, Samanta"' showing total 11 results
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11 results on '"Catueno, Samanta"'

2. Biological Markers of High-Risk Childhood Acute Lymphoblastic Leukemia

Author

He, Jiasen, primary, Munir, Faryal, additional, Catueno, Samanta, additional, Connors, Jeremy S., additional, Gibson, Amber, additional, Robusto, Lindsay, additional, McCall, David, additional, Nunez, Cesar, additional, Roth, Michael, additional, Tewari, Priti, additional, Garces, Sofia, additional, Cuglievan, Branko, additional, and Garcia, Miriam B., additional

Published
2024
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4. Menin inhibitors in pediatric acute leukemia: a comprehensive review and recommendations to accelerate progress in collaboration with adult leukemia and the international community

Author

Cuglievan, Branko, Kantarjian, Hagop, Rubnitz, Jeffrey E., Cooper, Todd M., Zwaan, C. Michel, Pollard, Jessica A., DiNardo, Courtney D., Kadia, Tapan M., Guest, Erin, Short, Nicholas J., McCall, David, Daver, Naval, Nunez, Cesar, Haddad, Fadi G., Garcia, Miriam, Bhalla, Kapil N., Maiti, Abhishek, Catueno, Samanta, Fiskus, Warren, Carter, Bing Z., Gibson, Amber, Roth, Michael, Khazal, Sajad, Tewari, Priti, Abbas, Hussein A., Bourgeois, Wallace, Andreeff, Michael, Shukla, Neerav N., Truong, Danh D., Connors, Jeremy, Ludwig, Joseph A., Stutterheim, Janine, Salzer, Elisabeth, Juul-Dam, Kristian L., Sasaki, Koji, Mahadeo, Kris M., Tasian, Sarah K., Borthakur, Gautam, Dickson, Samantha, Jain, Nitin, Jabbour, Elias, Meshinchi, Soheil, Garcia-Manero, Guillermo, Ravandi, Farhad, Stein, Eytan M., Kolb, E. Anders, and Issa, Ghayas C.

Abstract

Aberrant expression of HOXand MEIS1family genes, as seen in KMT2A-rearranged, NUP98-rearranged, or NPM1-mutated leukemias leads to arrested differentiation and leukemia development. HOXfamily genes are essential gatekeepers of physiologic hematopoiesis, and their expression is regulated by the interaction between KMT2Aand menin. Menin inhibitors block this interaction, downregulate the abnormal expression of MEIS1 and other transcription factors and thereby release the differentiation block. Menin inhibitors show significant clinical efficacy against KMT2A-rearranged and NPM1-mutated acute leukemias, with promising potential to address unmet needs in various pediatric leukemia subtypes. In this collaborative initiative, pediatric and adult hematologists/oncologists, and stem cell transplant physicians have united their expertise to explore the potential of menin inhibitors in pediatric leukemia treatment internationally. Our efforts aim to provide a comprehensive clinical overview of menin inhibitors, integrating preclinical evidence and insights from ongoing global clinical trials. Additionally, we propose future international, inclusive, and efficient clinical trial designs, integrating pediatric populations in adult trials, to ensure broad access to this promising therapy for all children and adolescents with menin-dependent leukemias.

Published
2024
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7. Coronavirus Disease 2019 in Pediatric Oncology Patients: A Matched–Cohort Analysis of the SCCM Discovery Viral Infection and Respiratory Illness Universal Study COVID-19 Registry

Author

Balakumar, Niveditha, primary, Catueno, Samanta, additional, Nadiger, Meghana, additional, Keshavamurthy, Prithvi Raj Sendi, additional, Totapally, Balagangadhar R, additional, Sherani, Farha, additional, Mba, Nkechi, additional, Gist, Katja M., additional, Tripathi, Sandeep, additional, Gajic, Ognjen, additional, Deo, Neha, additional, Kumar, Vishakha, additional, Walkey, Allan, additional, Kashyap, Rahul, additional, and Bhalala, Utpal S., additional

Published
2022
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9. Coronavirus Disease 2019 in Pediatric Oncology Patients: A Matched–Cohort Analysis of the SCCM Discovery Viral Infection and Respiratory Illness Universal Study COVID-19 Registry.

Author

Balakumar, Niveditha, Catueno, Samanta, Nadiger, Meghana, Keshavamurthy, Prithvi Raj Sendi, Totapally, Balagangadhar R., Sherani, Farha, Mba, Nkechi, Gist, Katja M., Tripathi, Sandeep, Gajic, Ognjen, Deo, Neha, Kumar, Vishakha, Walkey, Allan, Kashyap, Rahul, and Bhalala, Utpal S.

Published
2023
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