982 results on '"Cavalier E"'
Search Results
2. Intrinsic capacity and risk of death: Focus on the impact of using different diagnostic criteria for the nutritional domain
- Author
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Sanchez-Rodriguez, D., Demonceau, C., Bruyère, O., Cavalier, E., Reginster, J.-Y., and Beaudart, C.
- Published
- 2023
- Full Text
- View/download PDF
3. A global perspective on the status of clinical metabolomics
- Author
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Fux, E., primary, Bendt, A.K., additional, Cavalier, E., additional, De Bruyne, S., additional, Friedecky, D., additional, Ivanisevic, J., additional, Lenski, M., additional, and Otvos, J., additional
- Published
- 2024
- Full Text
- View/download PDF
4. Personalized assessment of vitamin D status by a novel metabolic approach
- Author
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Herrmann, M., primary, Zelzer, S., additional, Cavalier, E., additional, Kleber, M., additional, Drexler-Helmberg, C., additional, Schlenke, P., additional, Curcic, P., additional, Keppel, M., additional, Enko, D., additional, Scharnagl, H., additional, Pilz, S., additional, and März, W., additional
- Published
- 2024
- Full Text
- View/download PDF
5. Artificial intelligence to improve urine crystals recognition
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Gadisseur, R., primary, Yilmaz, T., additional, and Cavalier, E., additional
- Published
- 2024
- Full Text
- View/download PDF
6. How can the orthopedic surgeon ensure optimal vitamin D status in patients operated for an osteoporotic fracture?
- Author
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Chevalley, T., Brandi, M.L., Cavalier, E., Harvey, N.C., Iolascon, G., Cooper, C., Hannouche, D., Kaux, J.-F., Kurth, A., Maggi, S., Maier, G., Papavasiliou, K., Al-Daghri, N., Sosa-Henríquez, M., Suhm, N., Tarantino, U., Reginster, J.-Y., and Rizzoli, R.
- Published
- 2021
- Full Text
- View/download PDF
7. Intense sport practices and cardiac biomarkers
- Author
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Le Goff, C., Farré Segura, J., Dufour, P., Kaux, J.F., and Cavalier, E.
- Published
- 2020
- Full Text
- View/download PDF
8. Detection of wheat allergens using 2D Western blot and mass spectrometry
- Author
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Courtois, J., Bertholet, C., Tollenaere, S., Van der Brempt, X., Cavalier, E., El Guendi, S., Gillard, N., Gadisseur, R., and Quinting, B.
- Published
- 2020
- Full Text
- View/download PDF
9. Harmonization of commercial assays for PINP; the way forward
- Author
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Vasikaran, S. D., Bhattoa, H. P., Eastell, R., Heijboer, A. C., Jørgensen, N. R., Makris, K., Ulmer, C., Kanis, J. A., Cooper, C., Silverman, S., and Cavalier, E.
- Published
- 2020
- Full Text
- View/download PDF
10. Comparison of isotope pattern deconvolution and calibration curve quantification methods for the determination of estrone and 17β-estradiol in human serum
- Author
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Pitarch-Motellón, J., Fabregat-Cabello, N., Le Goff, C., Roig-Navarro, A.F., Sancho-Llopis, J.V., and Cavalier, E.
- Published
- 2019
- Full Text
- View/download PDF
11. Asessment of Q-value of serum creatinine in heterogenous population: Preliminary study of Indonesia initiative for renal function evaluation (INA-REN)
- Author
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Marpaung, F.R., Notobroto, H.B., Tjempakasari, A., Andari, S., Purnami, S.W., Cavalier, E., Aryati, and Santoso, D.
- Published
- 2024
- Full Text
- View/download PDF
12. Assessment of estimated kidney function based on creatinine in indonesian adult populations: Calling for validation of performance
- Author
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Marpaung, F.R., Notobroto, H.B., Tjempakasari, A., Andari, S., Purnami, S.W., Cavalier, E., Santoso, D., and Aryati
- Published
- 2024
- Full Text
- View/download PDF
13. Performance evaluation of the IgE allergy explorer chip
- Author
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Gadisseur, R., Israilov, M., Dezfoulian, B., and Cavalier, E.
- Published
- 2024
- Full Text
- View/download PDF
14. Strategic collaboration to address nitrous oxide challenges: Establishment of an international consortium of experts
- Author
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Gernez, E., Alpdemir, M., Anseeuw, K., Bjorke Monsen, A., Cavalier, E., Croes, K., El Khoury, J., Lee, G., Hamzic, J., Noyce, A., Stankovic, S., Vermeersch, P., and Grzych, G.
- Published
- 2024
- Full Text
- View/download PDF
15. Could KL-6 levels in COVID-19 help to predict lung disease?
- Author
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Frix, AN, Schoneveld, L., Ladang, A., Henket, M., Duysinx, B., Vaillant, F., Misset, B., Moutschen, M., Louis, R., Cavalier, E., and Guiot, J.
- Published
- 2020
- Full Text
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16. Critical analytical evaluation of promising markers for sarcopenia
- Author
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Cavalier, E., Beaudart, C., Buckinx, F., Bruyère, O., and Reginster, J.-Y.
- Published
- 2016
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17. Measurement of circulating 25-hydroxyvitamin D: A historical review
- Author
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Le Goff, C., Cavalier, E., Souberbielle, J.-C., González-Antuña, A., and Delvin, E.
- Published
- 2015
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18. KDIGO Guidelines and Kidney Transplantation: Is the Cystatin-C Based Recommendation Relevant?
- Author
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Masson, I., Maillard, N., Cavalier, E., Alamartine, E., Mariat, C., and Delanaye, P.
- Published
- 2015
- Full Text
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19. Osteoporosis in Frail Patients: A Consensus Paper of the Belgian Bone Club
- Author
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Gielen, E., Bergmann, P., Bruyère, O., Cavalier, E., Delanaye, P., Goemaere, S., Kaufman, J.-M., Locquet, M., Reginster, J.-Y., Rozenberg, S., Vandenbroucke, A.-M., and Body, J.-J.
- Published
- 2017
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20. Myoferlin regulates cellular lipid metabolism and promotes metastases in triple-negative breast cancer
- Author
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Blomme, A, Costanza, B, de Tullio, P, Thiry, M, Van Simaeys, G, Boutry, S, Doumont, G, Di Valentin, E, Hirano, T, Yokobori, T, Gofflot, S, Peulen, O, Bellahcène, A, Sherer, F, Le Goff, C, Cavalier, E, Mouithys-Mickalad, A, Jouret, F, Cusumano, P G, Lifrange, E, Muller, R N, Goldman, S, Delvenne, P, De Pauw, E, Nishiyama, M, Castronovo, V, and Turtoi, A
- Published
- 2017
- Full Text
- View/download PDF
21. How the reference values for serum parathyroid hormone concentration are (or should be) established?
- Author
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Souberbielle, J.-C., Brazier, F., Piketty, M.-L., Cormier, C., Minisola, S., and Cavalier, E.
- Published
- 2017
- Full Text
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22. Évolution de la densité minérale osseuse, et de la micro-architecture osseuse après transplantation rénale : résultats à 3 mois d’une étude de cohorte prospective
- Author
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Bouquegneau, A., primary, Malaise, O., additional, Seidel, L., additional, Bonvoisin, C., additional, Weekers, L., additional, Jouret, F., additional, Malaise, M., additional, Cavalier, E., additional, and Delanaye, P., additional
- Published
- 2022
- Full Text
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23. Impact des nouvelles équations EKFC et CKD-EPI (sans facteur ethnique) sur la prévalence de la maladie rénale chronique
- Author
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Delanaye, P., primary and Cavalier, E., additional
- Published
- 2022
- Full Text
- View/download PDF
24. ESICM LIVES 2016: part three: Milan, Italy. 1–5 October 2016
- Author
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Velasquez, T., Mackey, G., Lusk, J., Kyle, U. G., Fontenot, T., Marshall, P., Shekerdemian, L. S., Coss-Bu, J. A., Nishigaki, A., Yatabe, T., Tamura, T., Yamashita, K., Yokoyama, M., Ruiz-Rodriguez, J. C., Encina, B., Belmonte, R., Troncoso, I., Tormos, P., Riveiro, M., Baena, J., Sanchez, A., Bañeras, J., Cordón, J., Duran, N., Ruiz, A., Caballero, J., Nuvials, X., Riera, J., Serra, J., Rutten, A. M. F., van Ieperen, S. N. M., Der Kinderen, E. P. H. M., Van Logten, T., Kovacikova, L., Skrak, P., Zahorec, M., Kyle, U. G., Akcan-Arikan, A., Silva, J. C., Mackey, G., Lusk, J., Goldsworthy, M., Shekerdemian, L. S., Coss-Bu, J. A., Wood, D., Harrison, D., Parslow, R., Davis, P., Pappachan, J., Goodwin, S., Ramnarayan, P., Chernyshuk, S., Yemets, H., Zhovnir, V., Pulitano’, S. M., De Rosa, S., Mancino, A., Villa, G., Tosi, F., Franchi, P., Conti, G., Patel, B., Khine, H., Shah, A., Sung, D., Singer, L., Haghbin, S., Inaloo, S., Serati, Z., Idei, M., Nomura, T., Yamamoto, N., Sakai, Y., Yoshida, T., Matsuda, Y., Yamaguchi, Y., Takaki, S., Yamaguchi, O., Goto, T., Longani, N., Medar, S., Abdel-Aal, I. R., El Adawy, A. S., Mohammed, H. M. E. H., Mohamed, A. N., Parry, S. M., Knight, L. D., Denehy, L., De Morton, N., Baldwin, C. E., Sani, D., Kayambu, G., da Silva, V. Z. M., Phongpagdi, P., Puthucheary, Z. A., Granger, C. L., Rydingsward, J. E., Horkan, C. M., Christopher, K. B., McWilliams, D., Jones, C., Reeves, E., Atkins, G., Snelson, C., Aitken, L. M., Rattray, J., Kenardy, J., Hull, A. M., Ullman, A., Le Brocque, R., Mitchell, M., Davis, C., Macfarlane, B., Azevedo, J. C., Rocha, L. L., De Freitas, F. F. M., Cavalheiro, A. M., Lucinio, N. M., Lobato, M. S., Ebeling, G., Kraegpoeth, A., Laerkner, E., De Brito-Ashurst, I., White, C., Gregory, S., Forni, L. G., Flowers, E., Curtis, A., Wood, C. A., Siu, K., Venkatesan, K., Muhammad, J. B. H., Ng, L., Seet, E., Baptista, N., Escoval, A., Tomas, E., Agrawal, R., Mathew, R., Varma, A., Dima, E., Charitidou, E., Perivolioti, E., Pratikaki, M., Vrettou, C., Giannopoulos, A., Zakynthinos, S., Routsi, C., Atchade, E., Houzé, S., Jean-Baptiste, S., Thabut, G., Genève, C., Tanaka, S., Lortat-Jacob, B., Augustin, P., Desmard, M., Montravers, P., de Molina, F. J. González, Barbadillo, S., Alejandro, R., Álvarez-Lerma, F., Vallés, J., Catalán, R. M., Palencia, E., Jareño, A., Granada, R. M., Ignacio, M. L., Cui, N., Liu, D., Wang, H., Su, L., Qiu, H., Li, R., Jaffal, K., Rouzé, A., Poissy, J., Sendid, B., Nseir, S., Paramythiotou, E., Rizos, M., Frantzeskaki, F., Antoniadou, A., Vourli, S., Zerva, L., Armaganidis, A., Riera, J., Gottlieb, J., Greer, M., Wiesner, O., Martínez, M., Acuña, M., Rello, J., Welte, T., Atchade, E., Mignot, T., Houzé, S., Jean-Baptiste, S., Thabut, G., Lortat-Jacob, B., Tanaka, S., Augustin, P., Desmard, M., Montravers, P., Soussi, S., Dudoignon, E., Ferry, A., Chaussard, M., Benyamina, M., Alanio, A., Touratier, S., Chaouat, M., Lafaurie, M., Mimoun, M., Mebazaa, A., Legrand, M., Sheils, M. A., Patel, C., Mohankumar, L., Akhtar, N., Noriega, S. K. Pacheco, Aldana, N. Navarrete, León, J. L. Ávila, Baquero, J. Durand, Bernal, F. Fernández, Ahmadnia, E., Hadley, J. S., Millar, M., Hall, D., Hewitt, H., Yasuda, H., Sanui, M., Komuro, T., Kawano, S., Andoh, K., Yamamoto, H., Noda, E., Hatakeyama, J., Saitou, N., Okamoto, H., Kobayashi, A., Takei, T., Matsukubo, S., Rotzel, H. B., Lázaro, A. Serrano, Prada, D. Aguillón, Gimillo, M. Rodriguez, Barinas, O. Diaz, Cortes, M. L. Blasco, Franco, J. Ferreres, Roca, J. M. Segura, Carratalá, A., Gonçalves, B., Turon, R., Mendes, A., Miranda, F., Mata, P. J., Cavalcanti, D., Melo, N., Lacerda, P., Kurtz, P., Righy, C., Rosario, L. E. de la Cruz, Lesmes, S. P. Gómez, Romero, J. C. García, Herrera, A. N. García, Pertuz, E. D. Díaz, Sánchez, M. J. Gómez, Sanz, E. Regidor, Hualde, J. Barado, Hernández, A. Ansotegui, Irazabal, J. M. Guergué, Spatenkova, V., Bradac, O., Suchomel, P., Urli, T., Lazzeri, E. Heusch, Aspide, R., Zanello, M., Perez-Borrero, L., Garcia-Alvarez, J. M., Arias-Verdu, M. D., Aguilar-Alonso, E., Rivera-Fernandez, R., Mora-Ordoñez, J., De La Fuente-Martos, C., Castillo-Lorente, E., Guerrero-Lopez, F., Lesmes, S. P. Gómez, Rosario, L. E. De la Cruz, Pertuz, E. D. Díaz, Hernández, A. Ansotegui, Romero, J. C. García, Sánchez, M. J. Gómez, Herrera, A. N. García, Ramírez, J. Roldán, Sanz, E. Regidor, Hualde, J. Barado, León, J. P. Tirapu, Navarro-Guillamón, L., Cordovilla-Guardia, S., Iglesias-Santiago, A., Guerrero-López, F., Fernández-Mondéjar, E., Vidal, A., Perez, M., Juez, A., Arias, N., Colino, L., Perez, J. L., Pérez, H., Calpe, P., Alcala, M. A., Robaglia, D., Perez, C., Lan, S. K., Cunha, M. M., Moreira, T., Santos, F., Lafuente, E., Fernandes, M. J., Silva, J. G., Rosario, L. E. de la Cruz, Lesmes, S. P. Gómez, Herrera, A. N. García, Romero, J. C. García, Pertuz, E. D. Díaz, Sánchez, M. J. Gómez, Sanz, E. Regidor, Echeverría, J. G. Armando, Hernández, A. Ansotegui, Hualde, J. Barado, Podlepich, V., Sokolova, E., Alexandrova, E., Lapteva, K., Kurtz, P., Shuinotsuka, C., Rabello, L., Vianna, G., Reis, A., Cairus, C., Salluh, J., Bozza, F., Torres, J. C. Barrios, Araujo, N. J. Fernández, García-Olivares, P., Keough, E., Dalorzo, M., Tang, L. K., De Sousa, I., Díaz, M., Marcos-Zambrano, L. J., Guerrero, J. E., Gomez, S. E. Zamora, Lopez, G. D. Hernandez, Cuellar, A. I. Vazquez, Nieto, O. R. Perez, Gonzalez, J. A. Castanon, Bhasin, D., Rai, S., Singh, H., Gupta, O., Bhattal, M. K., Sampley, S., Sekhri, K., Nandha, R., Aliaga, F. A., Olivares, F., Appiani, F., Farias, P., Alberto, F., Hernández, A., Pons, S., Sonneville, R., Bouadma, L., Neuville, M., Mariotte, E., Radjou, A., Lebut, J., Chemam, S., Voiriot, G., Dilly, M. P., Mourvillier, B., Dorent, R., Nataf, P., Wolff, M., Timsit, J. F., Ediboglu, O., Ataman, S., Ozkarakas, H., Kirakli, C., Vakalos, A., Avramidis, V., Obukhova, O., Kurmukov, I. A., Kashiya, S., Golovnya, E., Baikova, V. N., Ageeva, T., Haritydi, T., Kulaga, E. V., Rios-Toro, J. J., Perez-Borrero, L., Aguilar-Alonso, E., Arias-Verdu, M. D., Garcia-Alvarez, J. M., Lopez-Caler, C., De La Fuente-Martos, C., Rodriguez-Fernandez, S., Sanchez-Orézzoli, M. Gomez, Martin-Gallardo, F., Nikhilesh, J., Joshi, V., Villarreal, E., Ruiz, J., Gordon, M., Quinza, A., Gimenez, J., Piñol, M., Castellanos, A., Ramirez, P., Jeon, Y. D., Jeong, W. Y., Kim, M. H., Jeong, I. Y., Ahn, M. Y., Ahn, J. Y., Han, S. H., Choi, J. Y., Song, Y. G., Kim, J. M., Ku, N. S., Shah, H., Kellner, F., Rezai, F., Mistry, N., Yodice, P., Ovnanian, V., Fless, K., Handler, E., Alejos, R. Martínez, Romeu, J. D. Martí, Antón, D. González, Quinart, A., Martí, A. Torres, Llaurado-Serra, M., Lobo-Civico, A., Ventura-Rosado, A., Piñol-Tena, A., Pi-Guerrero, M., Paños-Espinosa, C., Peralvo-Bernat, M., Marine-Vidal, J., Gonzalez-Engroba, R., Montesinos-Cerro, N., Treso-Geira, M., Valeiras-Valero, A., Martinez-Reyes, L., Sandiumenge, A., Jimenez-Herrera, M. F., Helyar, S., Riozzi, P., Noon, A., Hallows, G., Cotton, H., Keep, J., Hopkins, P. A., Taggu, A., Renuka, S., Sampath, S., Rood, P. J. T., Frenzel, T., Verhage, R., Bonn, M., Pickkers, P., van der Hoeven, J. G., van den Boogaard, M., Corradi, F., Melnyk, L., Moggia, F., Pienovi, R., Adriano, G., Brusasco, C., Mariotti, L., Lattuada, M., Bloomer, M. J., Coombs, M., Ranse, K., Endacott, R., Maertens, B., Blot, K., Blot, S., Amerongen, M. P. van Nieuw, van der Heiden, E. S., Twisk, J. W. R., Girbes, A. R. J., Spijkstra, J. J., Riozzi, P., Helyar, S., Cotton, H., Hallows, G., Noon, A., Bell, C., Peters, K., Feehan, A., Keep, J., Hopkins, P. A., Churchill, K., Hawkins, K., Brook, R., Paver, N., Endacott, R., Maistry, N., van Wijk, A., Rouw, N., van Galen, T., Evelein-Brugman, S., Taggu, A., Krishna, B., Sampath, S., Putzu, A., Fang, M., Berto, M. Boscolo, Belletti, A., Cassina, T., Cabrini, L., Mistry, M., Alhamdi, Y., Welters, I., Abrams, S. T., Toh, C. H., Han, H. S., Gil, E. M., Lee, D. S., Park, C. M., Winder-Rhodes, S., Lotay, R., Doyle, J., Ke, M. W., Huang, W. C., Chiang, C. H., Hung, W. T., Cheng, C. C., Lin, K. C., Lin, S. C., Chiou, K. R., Wann, S. R., Shu, C. W., Kang, P. L., Mar, G. Y., Liu, C. P., Dubó, S., Aquevedo, A., Jibaja, M., Berrutti, D., Labra, C., Lagos, R., García, M. F., Ramirez, V., Tobar, M., Picoita, F., Peláez, C., Carpio, D., Alegría, L., Hidalgo, C., Godoy, K., Bakker, J., Hernández, G., Sadamoto, Y., Katabami, K., Wada, T., Ono, Y., Maekawa, K., Hayakawa, M., Sawamura, A., Gando, S., Marin-Mateos, H., Perez-Vela, J. L., Garcia-Gigorro, R., Peiretti, M. A. Corres, Lopez-Gude, M. J., Chacon-Alves, S., Renes-Carreño, E., Montejo-González, J. C., Parlevliet, K. L., Touw, H. R. W., Beerepoot, M., Boer, C., Elbers, P. W. G., Tuinman, P. R., Abdelmonem, S. A., Helmy, T. A., El Sayed, I., Ghazal, S., Akhlagh, S. H., Masjedi, M., Hozhabri, K., Kamali, E., Zýková, I., Paldusová, B., Sedlák, P., Morman, D., Youn, A. M., Ohta, Y., Sakuma, M., Bates, D., Morimoto, T., Su, P. L., Chang, W. Y., Lin, W. C., Chen, C. W., Facchin, F., Zarantonello, F., Panciera, G., De Cassai, A., Venrdramin, A., Ballin, A., Tonetti, T., Persona, P., Ori, C., Del Sorbo, L., Rossi, S., Vergani, G., Cressoni, M., Chiumello, D., Chiurazzi, C., Brioni, M., Algieri, I., Tonetti, T., Guanziroli, M., Colombo, A., Tomic, I., Colombo, A., Crimella, F., Carlesso, E., Gasparovic, V., Gattinoni, L., Neto, A. Serpa, Schmidt, M., Pham, T., Combes, A., de Abreu, M. Gama, Pelosi, P., Schultz, M. J., Katira, B. H., Engelberts, D., Giesinger, R. E., Ackerley, C., Yoshida, T., Zabini, D., Otulakowski, G., Post, M., Kuebler, W. M., McNamara, P. J., Kavanagh, B. P., Pirracchio, R., Rigon, M. Resche, Carone, M., Chevret, S., Annane, D., Eladawy, S., El-Hamamsy, M., Bazan, N., Elgendy, M., De Pascale, G., Vallecoccia, M. S., Cutuli, S. L., Di Gravio, V., Pennisi, M. A., Conti, G., Antonelli, M., Andreis, D. T., Khaliq, W., Singer, M., Hartmann, J., Harm, S., Carmona, S. Alcantara, Almudevar, P. Matia, Abellán, A. Naharro, Ramos, J. Veganzones, Pérez, L. Pérez, Valbuena, B. Lobo, Sanz, N. Martínez, Simón, I. Fernández, Arrigo, M., Feliot, E., Deye, N., Cariou, A., Guidet, B., Jaber, S., Leone, M., Resche-Rigon, M., Baron, A. Vieillard, Legrand, M., Gayat, E., Mebazaa, A., Balik, M., Kolnikova, I., Maly, M., Waldauf, P., Tavazzi, G., Kristof, J., Herpain, A., Su, F., Post, E., Taccone, F., Vincent, J. L., Creteur, J., Lee, C., Hatib, F., Jian, Z., Buddi, S., Cannesson, M., Fileković, S., Turel, M., Knafelj, R., Gorjup, V., Stanić, R., Gradišek, P., Cerović, O., Mirković, T., Noč, M., Tirkkonen, J., Hellevuo, H., Olkkola, K. T., Hoppu, S., Lin, K. C., Hung, W. T., Chiang, C. C., Huang, W. C., Juan, W. C., Lin, S. C., Cheng, C. C., Lin, P. H., Fong, K. Y., Hou, D. S., Kang, P. L., Wann, S. R., Chen, Y. S., Mar, G. Y., Liu, C. P., Paul, M., Bougouin, W., Geri, G., Dumas, F., Champigneulle, B., Legriel, S., Charpentier, J., Mira, J. P., Sandroni, C., Cariou, A., Zimmerman, J., Sullivan, E., Noursadeghi, M., Fox, B., Sampson, D., McHugh, L., Yager, T., Cermelli, S., Seldon, T., Bhide, S., Brandon, R. A., Brandon, R. B., Zwaag, J., Beunders, R., Pickkers, P., Kox, M., Gul, F., Arslantas, M. K., Genc, D., Zibandah, N., Topcu, L., Akkoc, T., Cinel, I., Greco, E., Lauretta, M. P., Andreis, D. T., Singer, M., Garcia, I. Palacios, Cordero, M., Martin, A. Diaz, Pallás, T. Aldabó, Montero, J. Garnacho, Rey, J. Revuelto, Malo, L. Roman, Montoya, A. A. Tanaka, Martinez, A. D. C. Amador, Ayala, L. Y. Delgado, Zepeda, E. Monares, Granillo, J. Franco, Sanchez, J. Aguirre, Alejo, G. Camarena, Cabrera, A. Rugerio, Montenegro, A. Pedraza, Pham, T., Beduneau, G., Schortgen, F., Piquilloud, L., Zogheib, E., Jonas, M., Grelon, F., Runge, I., Terzi, N., Grangé, S., Barberet, G., Guitard, P. G., Frat, J. P., Constan, A., Chrétien, J. M., Mancebo, J., Mercat, A., Richard, J. C. M., Brochard, L., Soilemezi, E., Koco, E., Savvidou, S., Nouris, C., Matamis, D., Di Mussi, R., Spadaro, S., Volta, C. A., Mariani, M., Colaprico, A., Antonio, C., Bruno, F., Grasso, S., Rodriguez, A., Martín-Loeches, I., Díaz, E., Masclans, J. R., Gordo, F., Solé-Violán, J., Bodí, M., Avilés-Jurado, F. X., Trefler, S., Magret, M., Reyes, L. F., Marín-Corral, J., Yebenes, J. C., Esteban, A., Anzueto, A., Aliberti, S., Restrepo, M. I., Larsson, J. Skytte, Redfors, B., Ricksten, S. 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Iglesias, Sáez, V. Chica, Ruiz-Ruano, R. de la Chica, González, A. Sánchez, Kunze-Szikszay, N., Wand, S., Klapsing, P., Wetz, A., Heyne, T., Schwerdtfeger, K., Troeltzsch, M., Bauer, M., Quintel, M., Moerer, O., Cook, D. J., Rutherford, W. B., Scales, D. C., Adhikari, N. K., Cuthbertson, B. H., Suzuki, T., Takei, T., Fushimi, K., Iwamoto, M., Nakagawa, S., Mendsaikhan, N., Begzjav, T., Lundeg, G., Dünser, M. W., Romero, D. González, Cabrera, J. L. Santana, Santana, J. D. Martín, Padilla, Y. Santana, Pérez, H. Rodríguez, Torrent, R. Lorenzo, Kleinpell, R., Chouris, I., Radu, V., Stougianni, M., Lavrentieva, A., Lagonidis, D., Price, R. D. T., Day, A., Arora, N., Henderson, M. A., Hickey, S., Costa, M. I. Almeida, Carvalho, J. P., Gomes, A. A., Mergulhão, P. J., Chan, K. K. C., Shum, H. P., Yan, W. W., Maghsoudi, B., Tabei, S. H., Masjedi, M., Sabetian, G., Tabatabaei, H. R., Akbarzadeh, A., Saigal, S., Pakhare, A., Joshi, R., Pattnaik, S. K., Ray, B., Rousseau, A. F., Michel, L., Bawin, M., Cavalier, E., Reginster, J. Y., Damas, P., Bruyere, O., Zhou, J. C., Cauwenberghs, H., De Backer, A., Neels, H., Deblier, I., Berghmans, J., Himpe, D., Barea-Mendoza, J. A., Portillo, I. Prieto, Fernández, M. Valiente, Gigorro, R. Garcia, Vela, J. L. Perez, Mateos, H. Marín, Alves, S. Chacón, Varas, G. Morales, Rodriguez-Biendicho, A., Carreño, E. Renes, González, J. C. Montejo, Yang, J. S., Chiang, C. H., Hung, W. T., Huang, W. C., Cheng, C. C., Lin, K. C., Lin, S. C., Chiou, K. R., Wann, S. R., Lin, K. L., Kang, P. L., Mar, G. Y., Liu, C. P., Zhou, J. C., Choi, Y. J., Yoon, S. Z., Gordillo-Brenes, A., Fernandez-Zamora, M. D., Perez-Borrero, L., Arias-Verdu, M. D., Aguilar-Alonso, E., Herruzo-Aviles, A., Garcia-Delgado, M., Hinojosa-Perez, R., Curiel-Balsera, E., Rivera-Fernandez, R., Lesmes, S. P. Gómez, Rosario, L. E. De la Cruz, Hernández, A. Ansotegui, Herrera, A. N. García, Sanz, E. Regidor, Sánchez, M. J. Gómez, Hualde, J. Barado, Pascual, O. Agudo, León, J. P. Tirapu, Irazabal, J. M. Guergue, Pérez, A. González, Fernández, P. Alvarez, Amor, L. Lopéz, Albaiceta, G. Muñiz, Lesmes, S. P. Gómez, Rosario, L. E. De la Cruz, Hernández, A. Ansotegui, Sanz, E. Regidor, Sánchez, M. J. Gómez, Calvo, S. Aldunate, Herrera, A. N. García, Hualde, J. Barado, Pascual, O. Agudo, León, J. P. Tirapu, Corona, A., Ruffini, C., Spazzadeschi, A., Marrazzo, F., Gandola, A., Sciurti, R., Savi, C., Catena, E., Ke, M. W., Cheng, C. C., Huang, W. C., Chiang, C. H., Hung, W. T., Lin, K. C., Lin, S. C., Wann, S. R., Chiou, K. R., Tseng, C. J., Kang, P. L., Mar, G. Y., Liu, C. P., Bertini, P., De Sanctis, F., Guarracino, F., Bertini, P., Baldassarri, R., Guarracino, F., Buitinck, S. H., van der Voort, P. H. J., Oto, J., Nakataki, E., Tsunano, Y., Izawa, M., Tane, N., Onodera, M., Nishimura, M., Ghosh, S., Gupta, A., De Gasperi, A., Mazza, E., Limuti, R., Prosperi, M., Bissenova, N., Yergaliyeva, A., Talan, L., Yılmaz, G., Güven, G., Yoruk, F., Altıntas, N. D., Mukherjee, D. N., Agarwal, L. K., Mandal, K., Palomar, M., Balsera, B., Vallverdu, M., Martinez, M., Garcia, M., Castellana, D., Lopez, R., Barcenilla, F., Kaminsky, G. E., Carreño, R., Escribá, A., Fuentes, M., Gálvez, V., Del Olmo, R., Nieto, B., Vaquerizo, C., Alvarez, J., De la Torre, M. A., Torres, E., Bogossian, E., Nouer, S. Aranha, Salgado, D. Ribeiro, Brugger, S. Carvalho, Jiménez, G. Jiménez, Torner, M. Miralbés, Vidal, M. Vallverdú, Garrido, B. Balsera, Casals, X. Nuvials, Gaite, F. Barcenilla, Cabello, J. Trujillano, Martínez, M. Palomar, Doganci, M., Izdes, S., Besevli, S. Guzeldag, Alkan, A., Kayaaslan, B., Ramírez, C. Sánchez, Balcázar, L. Caipe, Santana, M. Cabrera, Viera, M. A. Hernández, Escalada, S. Hípola, Vázquez, C. F. Lübbe, Penichet, S. M. Marrero, Campelo, F. Artiles, López, M. A. De La Cal, Santana, P. Saavedra, Santana, S. Ruíz, Repessé, X., Artiguenave, M., Paktoris-Papine, S., Espinasse, F., Dinh, A., El Sayed, F., Charron, C., Géri, G., Vieillard-Baron, A., Marmanidou, K., Oikonomou, M., Nouris, C., Dimitroulakis, K., Soilemezi, E., Matamis, D., Ferré, A., Guillot, M., Teboul, J. L., Lichtenstein, D., Mézière, G., Richard, C., Monnet, X., Pham, T., Beduneau, G., Schortgen, F., Piquilloud, L., Zogheib, E., Jonas, M., Grelon, F., Runge, I., Terzi, N., Grangé, S., Barberet, G., Guitard, P. G., Frat, J. P., Constan, A., Chrétien, J. M., Mancebo, J., Mercat, A., Richard, J. C. M., Brochard, L., Prīdāne, S., Sabeļņikovs, O., Mojoli, F., Orlando, A., Bianchi, I., Torriglia, F., Bianzina, S., Pozzi, M., Iotti, G. A., Braschi, A., Beduneau, G., Pham, T., Schortgen, F., Piquilloud, L., Zogheib, E., Jonas, M., Grelon, F., Runge, I., Terzi, N., Grangé, S., Barberet, G., Guitard, P. G., Frat, J. P., Constan, A., Chrétien, J. M., Mancebo, J., Mercat, A., Richard, J. C. M., Brochard, L., Kondili, E., Psarologakis, C., Kokkini, S., Amargianitakis, V., Babalis, D., Chytas, A., Chouvarda, I., Vaporidi, K., Georgopoulos, D., Trapp, O., Kalenka, A., Mojoli, F., Orlando, A., Bianchi, I., Torriglia, F., Bianzina, S., Pozzi, M., Iotti, G. A., Braschi, A., Lozano, J. A. Benítez, Sánchez, P. Carmona, Francioni, J. E. Barrueco, Ferrón, F. Ruiz, Simón, J. M. Serrano, Spadaro, S., Karbing, D. S., Gioia, A., Moro, F., Corte, F. Dalla, Mauri, T., Volta, C. A., Rees, S. E., Petrova, M. V., Mohan, R., Butrov, A. V., Beeharry, S. D., Vatsik, M. V., Sakieva, F. I., Gobert, F., Yonis, H., Tapponnier, R., Fernandez, R., Labaune, M. A., Burle, J. F., Barbier, J., Vincent, B., Cleyet, M., Richard, J. C., Guérin, C., Shinotsuka, C. Righy, Creteur, J., Taccone, F. S., Törnblom, S., Nisula, S., Vaara, S., Poukkanen, M., Andersson, S., Pettilä, V., Pesonen, E., Xie, Z., Liao, X., Kang, Y., Zhang, J., Kubota, K., Egi, M., Mizobuchi, S., Hegazy, S., El-Keraie, A., El Sayed, E., El Hamid, M. Abd, Rodrigues, N. J., Pereira, M., Godinho, I., Gameiro, J., Neves, M., Gouveia, J., e Silva, Z. Costa, Lopes, J. A., Mckinlay, J., Kostalas, M., Kooner, G., Dudas, G., Horton, A., Kerr, C., Karanjia, N., Creagh-Brown, B., Forni, L., Yamazaki, A., Ganuza, M. Sanz, Molina, J. A. Martinez, Martinez, F. Hidalgo, Freile, M. T. Chiquito, Fernandez, N. Garcia, Travieso, P. Medrano, Bandert, A., Frithiof, R., Lipcsey, M., Smekal, D., Schlaepfer, P., Durovray, J. D., Plouhinec, V., Chiappa, C., Bellomo, R., Schneider, A. G., Mitchell, S., Durrant, J., Street, H., Dunthorne, E., Shears, J., Caballero, C. Hernandez, Hutchison, R., Schwarze, S., Ghabina, S., Thompson, E., Prowle, J. R., Kirwan, C. J., Gonzalez, C. A., Pinto, J. L., Orozco, V., Patiño, J. A., Garcia, P. K., Contreras, K. M., Rodriguez, P., Echeverri, J. E., GETGAG Working Group, JSEPTIC (Japanese Society of Education for Physicians and Trainees in Intensive Care) Clinical Trial Group, CAPCRI Study, for the ReVA Research Network and the PROVE Network Investigators, from the FROG ICU Investigators, The WIND study group, Plug Working Group, GETGAG/SEMICYUC, AKI Research Group, St George’s University of London, IPREA Study Group, FINNRESUSCI Study Group, PICS- HCPA: Programa Intrahospitalar de Combate à Sepse do Hospital de Clínicas de Porto Alegre, ENVIN-HELICS Study Group, ARIAM registry of adult cardiac surgery, The Rapid Diagnosis of Infections in the Critically Ill Team, Tokyo Womens Medical University, PLUG working group, PLUG Working Group, On behalf of Okayama Research Investigation Organizing Network (ORION)investigators, PS-ICU Group, Japan Septic Disseminated Intravascular Coagulation (JSEPTIC DIC) study group, Student Research Committee - Shiraz University of Medical Sciences, ARIAM-ANDALUCIA, The WIND study group, PLUG Working Group, The WIND study group, PLUG Working Group, and Plug working group
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- 2016
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25. The role of biochemical of bone turnover markers in osteoporosis and metabolic bone disease: a consensus paper of the Belgian Bone Club
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Cavalier, E., Bergmann, P., Bruyère, O., Delanaye, P., Durnez, A., Devogelaer, J.-P., Ferrari, S. L., Gielen, E., Goemaere, S., Kaufman, J.-M., Toukap, A. Nzeusseu, Reginster, J.-Y., Rousseau, A.-F., Rozenberg, S., Scheen, A. J., and Body, J.-J.
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- 2016
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26. Determinants of vitamin D supplementation prescription in nursing homes: a survey among general practitioners
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Buckinx, F., Reginster, J. Y., Cavalier, E., Petermans, J., Ricour, C., Dardenne, C., and Bruyère, O.
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- 2016
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27. A phase IV, two-armed, randomized, cross-over study comparing compliance with once-a-month administration of vitamin D3 to compliance with daily administration of a fixed-dose combination of vitamin D3 and calcium during two 6-month periods
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Bruyère, O., Deroisy, R., Dardenne, N., Cavalier, E., Coffiner, M., Da Silva, S., De Niet, S., and Reginster, J.-Y.
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- 2015
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28. M159 High-throughput fully automated laboratory solutions - alinity vs cobas - are results interchangeable
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Bertholet, C., primary, Lamtiri-Laarif, M., additional, Gadisseur, R., additional, Vranken, L., additional, Delcour, S., additional, and Cavalier, E., additional
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- 2022
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29. Suivi biologique du métabolisme phosphocalcique chez le patient dialysé : que nous apportent les guidelines du KDIGO en pratique ?
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Cavalier, E., Souberbielle, J.-C., and Delanaye, P.
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- 2012
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30. Professor Howard A. Morris
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Cavalier, E.
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- 2019
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31. Étude du profil en acylcarnitines après séjour prolongé aux soins intensifs
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Rousseau, A.-F., primary, Schmitz, S., additional, Colson, C., additional, Farrauto, L., additional, Minguet, P., additional, Cavalier, E., additional, Misset, B., additional, and Boemer, F., additional
- Published
- 2022
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- View/download PDF
32. American Bison (Bison bison) reproductive endocrinology: serum Pregnancy Associated Glycoproteins (PAG), Progesterone, Estrone and Estrone-Sulfate in non pregnant animals and during gestation
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Frisée, V., primary, Rigaux, G., additional, Dufour, P., additional, Barbato, O., additional, Brutinel, F., additional, Egyptien, S., additional, Bossaert, P., additional, Deleuze, S., additional, Cavalier, E., additional, and Ponthier, J., additional
- Published
- 2022
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33. P168 Matrix Gla protein, a potential marker of tissue remodelling and physiological ageing of the gut in Crohn’s Disease
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Vieujean, S, primary, Delanaye, P, additional, Seidel, L, additional, Cavalier, E, additional, Pierre, N, additional, and Louis, E, additional
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- 2022
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34. Vitamin D and type 2 diabetes mellitus: Where do we stand?
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Cavalier, E., Delanaye, P., Souberbielle, J.-C., and Radermecker, R.-P.
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- 2011
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35. Hypercalcémie aggravée par l’administration de vitamine D chez un patient adulte révélant une mutation hétérozygote composite CYP24A1 : réponse et traitement à long terme par rifampicine
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Parotte, M.C., primary, Valdes-Socin, H., additional, and Cavalier, E., additional
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- 2021
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36. Vitamin D status of schoolchildren in Northern Algeria, seasonal variations and determinants of vitamin D deficiency
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Djennane, M., Lebbah, S., Roux, C., Djoudi, H., Cavalier, E., and Souberbielle, J.-C.
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- 2014
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37. Estimation d’un ratio Albumine/Créatinine urinaire à partir d’un ratio Protéine/Créatinine urinaire au départ de mesures réalisées sur un même échantillon : validation d’équations
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Resimont, G., primary, Vranken, L., additional, Cavalier, E., additional, and Delanaye, P., additional
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- 2021
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38. Correction to: A Multicenter Study to Evaluate Harmonization of Assays for C-Terminal Telopeptides of Type I Collagen (ß-CTX): A Report from the IFCC-IOF Committee for Bone Metabolism (C-BM) (Calcified Tissue International, (2021), 108, 6, (785-797), 10.1007/s00223-021-00816-5)
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Cavalier, E. Eastell, R. Jørgensen, N.R. Makris, K. Tournis, S. Vasikaran, S. Kanis, J.A. Cooper, C. Pottel, H. Morris, H.A. on behalf of the IFCC-IOF Committee for Bone Metabolism (C-BM)
- Abstract
The original version of this article unfortunately contained a mistake in Fig. 1. The corrected Fig. 1 is given below. © 2021, The Author(s).
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- 2021
39. A Multicenter Study to Evaluate Harmonization of Assays for C-Terminal Telopeptides of Type I Collagen (ß-CTX): A Report from the IFCC-IOF Committee for Bone Metabolism (C-BM)
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Cavalier, E. Eastell, R. Jørgensen, N.R. Makris, K. Tournis, S. Vasikaran, S. Kanis, J.A. Cooper, C. Pottel, H. Morris, H.A. on behalf of the IFCC-IOF Committee for Bone Metabolism (C-BM)
- Abstract
Background: Biochemical bone turnover markers are useful tools to assess bone remodeling. C-terminal telopeptide of type I collagen (ß-CTX) has been recommended as a reference marker for bone resorption in research studies. Methods: We describe the results of a multicenter study for routine clinical laboratory assays for ß-CTX in serum and plasma. Four centers (Athens GR, Copenhagen DK, Liege BE and Sheffield UK) collected serum and plasma (EDTA) samples from 796 patients presenting to osteoporosis clinics. Specimens were analyzed in duplicate with each of the available routine clinical laboratory methods according to the manufacturers’ instructions. Passing-Bablok regressions, Bland–Altman plots, V-shape evaluation method, and Concordance correlation coefficient for ß-CTX values between serum and plasma specimens and between methods were used to determine the agreement between results. A generalized linear model was employed to identify possible variables that affected the relationship between the methods. Two pools of serum were finally prepared and sent to the four centers to be measured in 5-plicates on 5 consecutive days with the different methods. Results: We identified significant variations between methods and between centers although comparison results were generally more consistent in plasma compared to serum. We developed univariate linear regression equations to predict Roche Elecsys®, IDS-iSYS, or IDS ELISA ß-CTX results from any other assay and a multivariable model including the site of analysis, the age, and weight of the patient. The coefficients of determination (R2) increased from approximately 0.80 in the univariate model to approximately 0.90 in the multivariable one, with the site of analysis being the major contributing factor. Results observed on the pools also suggest that long-term storage could explain the difference observed with the different methods on serum. Conclusion: Our results show large within- and between-assay variation for ß-CTX measurement, particularly in serum. Stability of the analyte could be one of the explanations. More studies should be undertaken to overcome this problem. Until harmonization is achieved, we recommend measuring ß-CTX by the same assay on EDTA plasma, especially for research purposes in large pharmacological trials where samples can be stored for long periods before they are assayed. © 2021, The Author(s).
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- 2021
40. Analytical considerations and plans to standardize or harmonize assays for the reference bone turnover markers PINP and β-CTX in blood
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Bhattoa, H.P. Cavalier, E. Eastell, R. Heijboer, A.C. Jørgensen, N.R. Makris, K. Ulmer, C.Z. Kanis, J.A. Cooper, C. Silverman, S.L. Vasikaran, S.D.
- Abstract
Procollagen type I N-propeptide (PINP) and the C-terminal telopeptide of type I collagen (β-CTX) in blood have been designated as reference bone turnover markers in osteoporosis by the International Osteoporosis Foundation (IOF) and International Federation of Clinical Chemistry and Laboratory Medicine (IFCC). The IFCC Committee on Bone Metabolism (C-BM) has examined current commercial assays and performed a multicentre study to examine the agreement between assays for PINP and β-CTX in serum and plasma. The results of these studies will inform our work towards the harmonization of PINP assays and the standardization of β-CTX assays in blood, with the development of common calibrators and reference measurement procedures in collaboration with the reagent manufacturing industry. Successful achievement of these goals will help develop universally acceptable practice guidelines for the management of osteoporosis with the inclusion of common reference intervals and treatment targets for PINP and β-CTX. © 2020 Elsevier B.V.
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- 2021
41. The path to the standardization of PTH: Is this a realistic possibility? a position paper of the IFCC C-BM
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Cavalier, E. Vasikaran, S. Bhattoa, H.P. Heijboer, A.C. Makris, K. Ulmer, C.Z.
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endocrine system ,hormones, hormone substitutes, and hormone antagonists - Abstract
Parathyroid hormone (PTH) determination is of greatest importance for patients suffering from parathyroid gland disorders and for the follow-up of bone turnover in patients suffering from chronic kidney disease (CKD). Two generations of PTH assays are simultaneously present on the market for PTH quantification. As these assays are not yet standardized, this results in a significant level of confusion in the care of CKD patients. One key objective of the IFCC Committee for Bone Metabolism is to improve this situation. In this position paper, we will highlight the current state of PTH testing and propose a pathway to ultimately overcome issues resulting from PTH assay variability. © 2020
- Published
- 2021
42. POS-196 PATIENTS WITH COVID-19 MOSTLY RECOVER FROM TUBULAR PROTEINURIA AND ACUTE KIDNEY INJURY AFTER HOSPITAL DISCHARGE
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Bouquegneau, A., primary, Huart, J., additional, Lutteri, L., additional, Erpicum, P., additional, Grosch, S., additional, Résimont, G., additional, Wiesen, P., additional, Rousseau, A.F., additional, Bovy, C., additional, Krzesinski, J.M., additional, Thys, M., additional, Lambermont, B., additional, Misset, B., additional, Pottel, H., additional, Darcis, G., additional, Cavalier, E., additional, Jouret, F., additional, and Delanaye, P., additional
- Published
- 2021
- Full Text
- View/download PDF
43. Measurement uncertainty of 25-OH vitamin D determination with different commercially available kits: impact on the clinical cut offs
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Cavalier, E., Rozet, E., Gadisseur, R., Carlisi, A., Monge, M., Chapelle, J.-P., Hubert, P., Souberbielle, J.-C., and Delanaye, P.
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- 2010
- Full Text
- View/download PDF
44. P255Galectin-3: a new promising cardiac biomarker in sports endurance?
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Le Goff, C, Devaux, S, Brevers, E, Peeters, S, Kaux, JF, and Cavalier, E
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- 2014
- Full Text
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45. A preliminary study to assess neutrophil and endothelial response to knee arthroplasty with the use of a tourniquet : effects of spinal or sevoflurane anesthesia
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Minguet, G, primary, Franck, T, additional, Cavalier, E, additional, Daniel, C, additional, Serteyn, D, additional, Brichant, J.F., additional, and Joris, J, additional
- Published
- 2021
- Full Text
- View/download PDF
46. European Biological Variation Study (EuBIVAS):within- and between-subject biological variation estimates of β-isomerized C-terminal telopeptide of type I collagen (β-CTX), N-terminal propeptide of type I collagen (PINP), osteocalcin, intact fibroblast growth factor 23 and uncarboxylated-unphosphorylated matrix-Gla protein—a cooperation between the EFLM Working Group on Biological Variation and the International Osteoporosis Foundation-International Federation of Clinical Chemistry Committee on Bone Metabolism
- Author
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Cavalier, E., Lukas, P., Bottani, M., Aarsand, A. K., Ceriotti, F., Coşkun, A., Díaz-Garzón, J., Fernàndez-Calle, P., Guerra, E., Locatelli, M., Sandberg, S., Carobene, A., European Federation of Clinical Chemistry and Laboratory Medicine Working Group on Biological Variation and IOF-IFCC Committee on Bone Metabolism, Cooper, C., Kanis, J. A., Laboratory Medicine, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam Reproduction & Development (AR&D), Endocrinology Laboratory, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, AMS - Musculoskeletal Health, and Acibadem University Dspace
- Subjects
0301 basic medicine ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,Osteoporosis ,osteocalcin ,030209 endocrinology & metabolism ,Collagen Type I ,Bone remodeling ,Metabolic bone disease ,03 medical and health sciences ,bone markers ,0302 clinical medicine ,N-terminal telopeptide ,FGF23 ,Internal medicine ,Matrix gla protein ,Medicine ,Humans ,reference change value ,biological variation ,biology ,business.industry ,MGP ,medicine.disease ,C-terminal telopeptide ,Fibroblast Growth Factors ,Fibroblast Growth Factor-23 ,Endocrinology ,Biological Variation, Population ,PINP ,Chemistry, Clinical ,alpha-Galactosidase ,biology.protein ,Osteocalcin ,030101 anatomy & morphology ,CTX ,business ,Peptides ,Type I collagen ,Biomarkers ,FGF23 .MGP - Abstract
Summary: We have calculated the biological variation (BV) of different bone metabolism biomarkers on a large, well-described cohort of subjects. BV is important to calculate reference change value (or least significant change) which allows evaluating if the difference observed between two consecutive measurements in a patient is biologically significant or not. Introduction: Within-subject (CVI) and between-subject (CVG) biological variation (BV) estimates are essential in determining both analytical performance specifications (APS) and reference change values (RCV). Previously published estimates of BV for bone metabolism biomarkers are generally not compliant with the most up-to-date quality criteria for BV studies. We calculated the BV and RCV for different bone metabolism markers, namely β-isomerized C-terminal telopeptide of type I collagen (β-CTX), N-terminal propeptide of type I collagen (PINP), osteocalcin (OC), intact fibroblast growth factor 23 (iFGF-23), and uncarboxylated-unphosphorylated Matrix-Gla Protein (uCuP-MGP) using samples from the European Biological Variation Study (EuBIVAS). Methods: In the EuBIVAS, 91 subjects were recruited from six European laboratories. Fasting blood samples were obtained weekly for ten consecutive weeks. The samples were run in duplicate on IDS iSYS or DiaSorin Liaison instruments. The results were subjected to outlier and variance homogeneity analysis before CV-ANOVA was used to obtain the BV estimates. Results: We found no effect of gender upon the CVI estimates. The following CVI estimates with 95% confidence intervals (95% CI) were obtained: β-CTX 15.1% (14.4–16.0%), PINP 8.8% (8.4–9.3%), OC 8.9% (8.5–9.4%), iFGF23 13.9% (13.2–14.7%), and uCuP-MGP 6.9% (6.1–7.3%). Conclusions: The EuBIVAS has provided updated BV estimates for bone markers, including iFGF23, which have not been previously published, facilitating the improved follow-up of patients being treated for metabolic bone disease.
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- 2020
47. Harmonization of commercial assays for PINP; the way forward
- Author
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Vasikaran, S.D. Bhattoa, H.P. Eastell, R. Heijboer, A.C. Jørgensen, N.R. Makris, K. Ulmer, C. Kanis, J.A. Cooper, C. Silverman, S. Cavalier, E.
- Abstract
Summary: International Federation of Clinical Chemistry and Laboratory Medicine and The International Osteoporosis Foundation Joint Committee on Bone Metabolism believes that the harmonization of PINP assays is an achievable and practical goal. Introduction: In order to examine the agreement between current commercial assays, a multi-center study was performed for PINP in serum and plasma. Methods: The automated methods for PINP (Roche Cobas and IDS iSYS) gave similar results. A significant proportional bias was observed between the two automated assays and the Orion radioimmunoassay (RIA) for PINP. Results: Results from other published studies comparing PINP values among these three assays broadly support our findings. Taken together, these results confirm that harmonized PINP measurements exist between the two automated assays (Roche Cobas and IDS iSYS) when the eGFR is > 30 mL/min/1.73m2, but a significant bias exists between the Orion RIA and the two automated assays. Conclusion: Therefore, in subjects with normal renal function, PINP results reported by the Roche Cobas and IDS iSYS assays are similar and may be used interchangeably, and similar reference intervals and treatment targets could be applied for the two automated assays. Harmonization between the automated assays and the RIA is potentially possible with the use of common calibrators and the development of a reference method for PINP. This should also help ensure that any new commercial assay developed in the future will attain similar results. IOF and IFCC are committed to working together towards this goal with the cooperation of the reagent manufacturing industry. © 2020, International Osteoporosis Foundation and National Osteoporosis Foundation.
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- 2020
48. Cardiovascular risk in patients with primary hyperparathyroidism
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Tournis, S. Makris, K. Cavalier, E. Trovas, G.
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endocrine system diseases - Abstract
Primary hyperparathyroidism (PHPT) is one of the most common endocrine disorders characterized by parathyroid hormone (PTH)-dependent hypercalcemia. Cardinal features include low trauma fractures, nephrolithiasis, and chronic kidney disease. Several experimental studies established that parathyroid hormone exerts actions on the cardiovascular (CV) system, including vasodilatation and positive inotropic and chronotropic effects. Observational studies, especially in severe cases, report a higher prevalence of hypertension, diabetes mellitus, lipid abnormalities, endothelial dysfunction, arrhythmias, and left ventricular hypertrophy in patients with PHPT, while the risk of CV events seems to be increased in severe cases. However, the effect of surgery is inconsistent on CV abnormalities and, more importantly, on CV disease (CVD) events, especially in mild cases. In the current review, we describe the available evidence linking PHPT and CVD, as well as the effect of surgical management and pharmacological treatment on CVD manifestations in patients with PHPT. Based on the current evidence, CVD is not considered an indication for surgery. © 2020 Bentham Science Publishers.
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- 2020
49. Algorithm for the use of biochemical markers of bone turnover in the diagnosis, assessment and follow-up of treatment for osteoporosis
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Lorentzon, M., Branco, Jaime, Brandi, Maria Luisa, Bruyère, Olivier, Chapurlat, Roland, Cooper, Cyrus, Cortet, Bernard, Díez Pérez, Adolfo, Ferrari, S., Gasparik, A., Herrmann, M., Jorgensen, N. R., Kanis, J., Kaufman, J. M., Laslop, A., Locquet, Medea, Matijevic, Radmila, McCloskey, E., Minisola, S., Pikner, R., Reginster, Jean-Yves, Rizzoli, R., Szulc, P., Vlaskovska, M., Cavalier, E., and Universitat Autònoma de Barcelona
- Subjects
030213 general clinical medicine ,TERIPARATIDE ,Treatment adherence ,Osteoporosis ,FRACTURE RISK ,algorithm ,bone ,bone biomarker ,CTX ,osteoporosis ,P1NP ,rheumatology ,Postmenopausal osteoporosis ,Bone remodeling ,METABOLISM MARKERS ,RISEDRONATE ,DOUBLE-BLIND ,0302 clinical medicine ,Bone Density ,Reference Values ,Medicine and Health Sciences ,Pharmacology (medical) ,Biochemical markers ,Osteoporosis, Postmenopausal ,Original Research ,ddc:616 ,Aged, 80 and over ,Bone Density Conservation Agents ,Diphosphonates ,General Medicine ,Middle Aged ,Treatment efficacy ,Algorithm ,INTERNATIONAL OSTEOPOROSIS ,Treatment Outcome ,POSTMENOPAUSAL WOMEN ,Bone biomarker ,030220 oncology & carcinogenesis ,Female ,Bone Remodeling ,Algorithms ,psteoporosis ,medicine.medical_specialty ,VERTEBRAL FRACTURES ,03 medical and health sciences ,Rheumatology ,Internal medicine ,medicine ,Humans ,In patient ,Bone ,Aged ,DENOSUMAB ,business.industry ,medicine.disease ,RANDOMIZED-TRIAL ,business ,Biomarkers ,Follow-Up Studies - Abstract
Introduction\ud \ud Increased biochemical bone turnover markers (BTMs) measured in serum are associated with bone loss, increased fracture risk and poor treatment adherence, but their role in clinical practice is presently unclear. The aim of this consensus group report is to provide guidance to clinicians on how to use BTMs in patient evaluation in postmenopausal osteoporosis, in fracture risk prediction and in the monitoring of treatment efficacy and adherence to osteoporosis medication.\ud \ud \ud \ud Methods\ud \ud A working group with clinical scientists and osteoporosis specialists was invited by the Scientific Advisory Board of European Society on Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO).\ud \ud \ud \ud Results\ud \ud Serum bone formation marker PINP and resorption marker βCTX-I are the preferred markers for evaluating bone turnover in the clinical setting due to their specificity to bone, performance in clinical studies, wide use and relatively low analytical variability. BTMs cannot be used to diagnose osteoporosis because of low sensitivity and specificity, but can be of value in patient evaluation where high values may indicate the need to investigate some causes of secondary osteoporosis. Assessing serum levels of βCTX-I and PINP can improve fracture prediction slightly, with a gradient of risk of about 1.2 per SD increase in the bone marker in addition to clinical risk factors and bone mineral density. For an individual patient, BTMs are not useful in projecting bone loss or treatment efficacy, but it is recommended that serum PINP and βCTX-I be used to monitor adherence to oral bisphosphonate treatment. Suppression of the BTMs greater than the least significant change or to levels in the lower half of the reference interval in young and healthy premenopausal women is closely related to treatment adherence.\ud \ud \ud \ud Conclusion\ud \ud In conclusion, the currently available evidence indicates that the principal clinical utility of BTMs is for monitoring oral bisphosphonate therapy.
- Published
- 2019
50. Vitamin D and Type 2 Diabetes Mellitus
- Author
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Cavalier, E., primary
- Published
- 2013
- Full Text
- View/download PDF
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