538 results on '"Cavalieri D."'
Search Results
2. Predicting diabetic retinopathy stage using Siamese Convolutional Neural Network.
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Santos, M. S., Valadao, C. T., Resende, C. Z., and Cavalieri, D. C.
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CONVOLUTIONAL neural networks ,ARTIFICIAL neural networks ,IMAGE recognition (Computer vision) ,DIABETIC retinopathy ,IMAGE analysis ,DEEP learning - Abstract
Diabetic retinopathy (DR) is considered to be a leading cause of blindness in people aged 16 to 64 years, affecting around 40% of the population diagnosed with diabetes mellitus (DM). DR is usually identified through retinal image analysis, and in some countries, such as Brazil, such diagnosis is hindered by limited access to specialized care, leading to lengthy waits for ophthalmological evaluations. This scenario makes the Brazilian Diabetic Society's annual DR check recommendation impractical for many. To address this gap, our study introduces a novel Siamese Convolutional Neural Network (SCNN) for DR prediction, usable by primary care professionals. Our SCNN analyzes pairs of eye fundus images and employs shared weights in its layers to extract essential features, facilitating similarity measurement between neural network outputs. Despite challenges with limited and imbalanced datasets, our SCNN showed effectiveness. We tested it on four datasets (IDRiD, APTOS, Messidor-1, DIARETDB0), with accuracy ranging from 67.23% (APTOS) to 96.85% (DIARETDB0). Compared to other methods, our approach consistently excelled, especially in recall analysis. These results suggest that deep learning via Siamese networks is likely to be a viable and potential DR screening tool. [ABSTRACT FROM AUTHOR]
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- 2024
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3. Estimating complete cancer prevalence in Europe: validity of alternative vs standard completeness indexes
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Elena Demuru, Silvia Rossi, Leonardo Ventura, Luigino Dal Maso, Stefano Guzzinati, Alexander Katalinic, Sebastien Lamy, Valerie Jooste, Corrado Di Benedetto, Roberta De Angelis, the EUROCARE-6 Working Group, M. Hackl, E. Van Eycken, N. Van Damme, Z. Valerianova, M. Sekerija, V. Scoutellas, A. Demetriou, L. Dušek, D. Krejici, H. Storm, M. Mägi, K. Innos, N. Malila, J. Pitkäniemi, M. Velten, X. Troussard, A.M. Bouvier, V. Jooste, A.V. Guizard, S. Dabakuyo Yonli, M. Maynadié, J.B. Nousbaum, G. Coureau, A. Monnereau, I. Baldi, K. Hammas, B. Tretarre, M. Colonna, S. Plouvier, T. D’Almeida, F. Molinié, A. Cowppli-Bony, S. Bara, G. Defossez, B. LapÔtre-Ledoux, P. Grosclaude, L. Daubisse-Marliac, S. Luttmann, R. Stabenow, A. Nennecke, J. Kieschke, S. Zeissig, B. Holleczek, A. Katalinic, H. Birgisson, D. Murray, P.M. Walsh, G. Mazzoleni, F. Vittadello, F. Cuccaro, R. Galasso, G. Sampietro, S. Rosso, C. Gasparotti, G. Maifredi, M. Ferrante, R. Ragusa, M.L. Gambino, M. Lanzoni, P. Ballotari, E. Giacomazzi, S. Ferretti, A. Caldarella, G. Manneschi, G. Gatta, M. Sant, P. Baili, F. Berrino, L. Botta, A. Trama, R. Lillini, A. Bernasconi, L. Bonfarnuzzo, C. Vener, F. Didoné, P. Lasalvia, G. Del Monego, L. Buratti, G. Tagliabue, D. Serraino, L. Dal Maso, R. Capocaccia, R. De Angelis, E. Demuru, C. Di Benedetto, S. Rossi, M. Santaquilani, S. Venanzi, M. Tallon, L. Boni, S. Iacovacci, V. Gennaro, A.G. Russo, F. Gervasi, G. Spagnoli, L. Cavalieri d’’Oro, M. Fusco, M.F. Vitale, M. Usala, W. Mazzucco, M. Michiara, G. Chiranda, G. Cascone, C.P. Rollo, L. Mangone, F. Falcini, R. Cavallo, D. Piras, A. Madeddu, F. Bella, A.C. Fanetti, S. Minerba, G. Candela, T. Scuderi, R.V. Rizzello, M. Rugge, A. Brustolin, S. Pildava, G. Smailyte, M. Azzopardi, T.B. Johannesen, J. Didkowska, U. Wojciechowska, M. Bielska-Lasota, A. Pais, J. Rodrigues, M.J. Bento, A. Miranda, V. Zadnik, T. Zagar, C. Sánchez-Contador Escudero, P. Franch Sureda, A. Lopez de Munain, M. De-La-Cruz, M.D. Rojas, A. Aleman, A. Vizcaino, R. Marcos-Gragera, A. Sanvisens, M.J. Sanchez, M.D. Chirlaque, A. Sanchez-Gil, M. Guevara, E. Ardanaz, A. Ameijide, C. Carulla, Y. Bergeron, C. Bouchardy, S. Mohsen Mousavi, P. Went, M. Blum, A. Bordoni, O. Visser, S. Stevens, J. Broggio, A. Gavin, D. Morrison, and D.W. Huws
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cancer prevalence ,cancer registries ,cancer survivors ,cancer survivorship ,EUROCARE ,Europe ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
IntroductionComparable indicators on complete cancer prevalence are increasingly needed in Europe to support survivorship care planning. Direct measures can be biased by limited registration time and estimates are needed to recover long term survivors. The completeness index method, based on incidence and survival modelling, is the standard most validated approach.MethodsWithin this framework, we consider two alternative approaches that do not require any direct modelling activity: i) empirical indices derived from long established European registries; ii) pre-calculated indices derived from US-SEER cancer registries. Relying on the EUROCARE-6 study dataset we compare standard vs alternative complete prevalence estimates using data from 62 registries in 27 countries by sex, cancer type and registration time.ResultsFor tumours mostly diagnosed in the elderly the empirical estimates differ little from standard estimates (on average less than 5% after 10-15 years of registration), especially for low prognosis cancers. For early-onset cancers (bone, brain, cervix uteri, testis, Hodgkin disease, soft tissues) the empirical method may produce substantial underestimations of complete prevalence (up to 20%) even when based on 35-year observations. SEER estimates are comparable to the standard ones for most cancers, including many early-onset tumours, even when derived from short time series (10-15 years). Longer observations are however needed when cancer-specific incidence and prognosis differ remarkably between US and European populations (endometrium, thyroid or stomach).DiscussionThese results may facilitate the dissemination of complete prevalence estimates across Europe and help bridge the current information gaps.
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- 2023
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4. BOC.01.2: THE IMPACT OF UNNECESSARY GLUTEN-FREE DIET ON GUT MICROBIOTA
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Manza, F., primary, Lungaro, L., additional, Costanzini, A., additional, Segata, N., additional, Pinto, F., additional, Puncochár, M., additional, Asnicar, F., additional, Armanini, F., additional, Carroccio, A., additional, Mansueto, P., additional, Calabrò, A., additional, Cavalieri, D., additional, Barbara, G., additional, Stanghellini, V., additional, Volta, U., additional, De Giorgio, R., additional, and Caio, G., additional
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- 2024
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5. Microbiota and environmental stress: how pollution affects microbial communities in Manila clams
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Milan, M., Carraro, L., Fariselli, P., Martino, M.E., Cavalieri, D., Vitali, F., Boffo, L., Patarnello, T., Bargelloni, L., and Cardazzo, B.
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- 2018
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6. A Hybrid Model based on Genetic Algorithm and Space-Filling Curve applied to Optimization of Vehicle Routes
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MENDES, W. R., PEREIRA, F. G., and CAVALIERI, D. C.
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vehicle routing ,genetic algorithms ,fractals ,hybrid intelligent systems ,computer applications ,Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 ,Computer engineering. Computer hardware ,TK7885-7895 - Abstract
This work is the result of a real problem in the Sanitation Company of Espirito Santo (Companhia Espirito Santense de Saneamento), which owns a Geographic Information System, but lacks a mechanism to build routes to server customers that open in average 2148 services requests per day. Therefore, we propose a Hybrid Optimization Algorithm that combines Genetic Algorithm and Space-Filling Curves to solve the Vehicle Route Problem. We establish the validity of the hybrid algorithm by performing tests in two different benchmarks datasets. Our proposal reached an average result of 12.7 percent and 4.1 percent better than the previous solutions in the first and second datasets respectively. Also, we compare our solution and five other variations of Ant Colony Optimization Algorithm. The results show that our proposal is superior in some simulations and, when it was not superior, presented the second-best results for almost all instances.
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- 2018
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7. The Transition of Care for Patients with Anorectal Malformations and Hirschsprung Disease: A European Survey
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Violani, C., Grano, C., Fernandes, M., Prato, A.P., Feitz, W.F.J., Wijnen, R., Battye, M., Schwarzer, N., Lemli, A., Cavalieri, D., Aminoff, D., Violani, C., Grano, C., Fernandes, M., Prato, A.P., Feitz, W.F.J., Wijnen, R., Battye, M., Schwarzer, N., Lemli, A., Cavalieri, D., and Aminoff, D.
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Item does not contain fulltext, This study aimed at evaluating how transition of care is currently being organized in the European Reference Networks (ERNs) health care providers (HCPs) in pediatric areas and in the Anorectal Malformation Network (ARM-Net) Consortium hospitals. An online questionnaire was sent to a total of 80 surgeons, members of or affiliated members of three networks: ARM-Net Consortium, ERN eUROGEN, and ERN ERNICA. Complete information were obtained for 45 HCPs, most of which deal with transition and still see a few adult patients (ca. 10%). Gynecological, gastroenterological, urological, colorectal, and continence issues were the major problems described by adult patients to their physicians, and in line with these prevalent complaints, they are referred to the appropriate adult specialists. Forty percent of patients complain about sexual and fertility problems, but the percentage of andrologists and sexologists involved in the caring of adult patients with ARM/Hirschsprung's disease is low, just above 10.9%. Most hospitals deal with transition, but three basic criteria (i.e., presence of: [1] an official written transitional program, [2] a transitional coordinator, and [3] written information on transition to be handled to patients) are jointly met only by six HCPs. According to the responders, the most important issue requiring improvement is the lack of interest and of specific preparation by adult specialists. The overall results of this exploratory survey confirm the need for the development of comprehensive programs for transition in these rare and complex diseases, and identify the hospitals that, in collaboration with the networks, could share best practices in organizing structured transitional pathways and well follow-ups.
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- 2023
8. Tandem haematopoietic stem cell transplantation versus single cell transplant and BV maintenance in relapsed/refractory Hodgkin lymphoma: A matched cohort analysis from the LYSA
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Marouf, A., primary, Molinari, N., additional, Sibon, D., additional, Cottereau, A. S., additional, Kanoun, S., additional, Antoine, C., additional, Debureaux, P. E., additional, Cavalieri, D., additional, Fornecker, L. M., additional, Casasnovas, R. O., additional, Herbaux, C., additional, Amorim, S., additional, Rossi, C., additional, Bouscary, D., additional, Brice, P., additional, Ghesquieres, H., additional, Tamburini, J., additional, and Deau, B., additional
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- 2023
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9. The Root of Flowering Plants and Total Evidence
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Goremykin, V. V., Nikiforova, S. V., Cavalieri, D., Pindo, M., and Lockhart, Peter
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- 2015
10. A Novel Multi-Fidelity Framework for Conventional and Alternative Jet Fuel Combustion Characterization
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Liberatori, J., Cavalieri, D., Malpica Galassi, R., Valorani, M., and Ciottoli, P. P.
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sustainable aviation fuels ,aerospace propulsion ,climate-neutral aviation ,fuel surrogates ,statistical inference - Published
- 2023
11. Compliance e saúde mental nas organizações
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CAVALIERI, D. V. G., primary
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- 2023
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12. Pressure effects on turbulent pseudo-boiling rate
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Cavalieri, D., primary and Lapenna, Pasquale Eduardo, additional
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- 2023
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13. Nod2 Deficiency in mice is Associated with Microbiota Variation Favouring the Expansion of mucosal CD4+ LAP+ Regulatory Cells
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Butera, A., Di Paola, M., Pavarini, L., Strati, F., Pindo, M., Sanchez, M., Cavalieri, D., Boirivant, M., and De Filippo, C.
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- 2018
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14. Gut microbiota profiles and characterization of cultivable fungal isolates in IBS patients
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Sciavilla, P, Strati, F, Di Paola, M, Modesto, M, Vitali, F, Cavalieri, D, Prati, G, Di Vito, M, Aragona, G, De Filippo, C, Mattarelli, P, Sciavilla P, Strati F, Di Paola M, Modesto M, Vitali F, Cavalieri D, Prati G.M, Di Vito M, Aragona G, De Filippo C, Mattarelli P., Sciavilla, P, Strati, F, Di Paola, M, Modesto, M, Vitali, F, Cavalieri, D, Prati, G, Di Vito, M, Aragona, G, De Filippo, C, Mattarelli, P, Sciavilla P, Strati F, Di Paola M, Modesto M, Vitali F, Cavalieri D, Prati G.M, Di Vito M, Aragona G, De Filippo C, and Mattarelli P.
- Abstract
Studies so far conducted on irritable bowel syndrome (IBS) have been focused mainly on the role of gut bacterial dysbiosis in modulating the intestinal permeability, inflammation, and motility, with consequences on the quality of life. Limited evidences showed a potential involvement of gut fungal communities. Here, the gut bacterial and fungal microbiota of a cohort of IBS patients have been characterized and compared with that of healthy subjects (HS). The IBS microbial community structure differed significantly compared to HS. In particular, we observed an enrichment of bacterial taxa involved in gut inflammation, such as Enterobacteriaceae, Streptococcus, Fusobacteria, Gemella, and Rothia, as well as depletion of health-promoting bacterial genera, such as Roseburia and Faecalibacterium. Gut microbial profiles in IBS patients differed also in accordance with constipation. Sequence analysis of the gut mycobiota showed enrichment of Saccharomycetes in IBS. Culturomics analysis of fungal isolates from feces showed enrichment of Candida spp. displaying from IBS a clonal expansion and a distinct genotypic profiles and different phenotypical features when compared to HS of Candida albicans isolates. Alongside the well-characterized gut bacterial dysbiosis in IBS, this study shed light on a yet poorly explored fungal component of the intestinal ecosystem, the gut mycobiota. Our results showed a differential fungal community in IBS compared to HS, suggesting potential for new insights on the involvement of the gut mycobiota in IBS. Key points: • Comparison of gut microbiota and mycobiota between IBS and healthy subjects • Investigation of cultivable fungi in IBS and healthy subjects • Candida albicans isolates result more virulent in IBS subjects compared to healthy subjects.
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- 2021
15. Observed Hemispheric Asymmetry in Global Sea Ice Changes
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Cavalieri, D. J., Gloersen, P., Parkinson, C. L., Comiso, J. C., and Zwally, H. J.
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- 1997
16. Tandem versus single haematopoietic stem cell transplant and BV maintenance in relapsed/refractory Hodgkin lymphoma: A matched cohort analysis from the LYSA.
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Marouf, A., Molinari, N., Sibon, D., Cottereau, A. S., Kanoun, S., Antoine, C., Debureaux, P. E., Cavalieri, D., Fornecker, L. M., Casasnovas, R. O., Herbaux, C., Amorim, S., Rossi, C., Bouscary, D., Brice, P., Ghesquieres, H., Tamburini, J., and Deau, B.
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HEMATOPOIETIC stem cells ,STEM cell transplantation ,HODGKIN'S disease ,COHORT analysis ,SURVIVAL rate - Abstract
Summary: Autologous hematopoietic stem cell transplant (ASCT) is the standard curative treatment for patients with high‐risk relapsed/refractory Hodgkin lymphoma (R/R HL). The AETHERA study showed survival gain with Brentuximab Vedotin (BV) maintenance after ASCT in BV‐naive patients, which was recently confirmed in the retrospective AMAHRELIS cohort, including a majority of BV‐exposed patients. However, this approach has not been compared to intensive tandem auto/auto or auto/allo transplant strategies, which were used before BV approval. Here, we matched BV maintenance (AMAHRELIS) and tandem SCT (HR2009) cohorts, and observed that BV maintenance was associated with better survival outcome in patients with HR R/R HL. [ABSTRACT FROM AUTHOR]
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- 2023
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17. Effects of near-infrared laser radiation on the survival and inflammatory potential of Candida spp. involved in the pathogenesis of chemotherapy-induced oral mucositis
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Clemente, A. M., Rizzetto, L., Castronovo, G., Perissi, E., Tanturli, M., Cozzolino, F., Cavalieri, D., Fusi, F., Cialdai, F., Vignali, L., Torcia, M. G., and Monici, M.
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- 2015
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18. ALK-negative anaplastic large cell lymphoma with DUSP22 rearrangement has distinctive disease characteristics with better progression-free survival: a LYSA study
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Sibon, D., Bisig, B., Bonnet, C., Poullot, E., Bachy, E., Cavalieri, D., Fataccioli, V., Bregnard, C., Drieux, F., Bruneau, J., Lemonnier, F., Dupuy, A., Bossard, C., Parrens, M., Bouabdallah, K., Ketterer, N., Berthod, G., Cairoli, A., Damaj, G., Tournilhac, O., Jais, J.P., Gaulard, P., and De Leval, L.
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Hematology - Abstract
ALK-negative anaplastic large cell lymphoma (ALCL) comprises subgroups harboring rearrangements of DUSP22 (DUSP22- R) or TP63 (TP63-R). Two studies reported 90% and 40% 5-year overall survival (OS) rates in 21 and 12 DUSP22-R/TP63- not rearranged (NR) patients, respectively, making the prognostic impact of DUSP22-R unclear. Here, 104 newly diagnosed ALK-negative ALCL patients (including 37 from first-line clinical trials) from the LYSA TENOMIC database were analyzed by break-apart fluorescence in situ hybridization assays for DUSP22-R and TP63-R. There were 47/104 (45%) DUSP22-R and 2/93 (2%) TP63-R cases, including one DUSP22-R/TP63-R case. DUSP22-R tumors more frequently showed CD3 expression (62% vs. 35%, P=0.01), and less commonly a cytotoxic phenotype (27% vs. 82%; P
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- 2022
19. Differences in thrombin and plasmin generation potential between East African and Western European adults: The role of genetic and non-genetic factors
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Temba, G.S., Vadaq, N., Wan, J., Kullaya, V., Huskens, D., Pecht, T., Jaeger, M., Boahen, C.K., Matzaraki, V., Broeders, W., Joosten, L.A.B., Faradz, S.M., Kibiki, G.S., Middeldorp, S., Cavalieri, D., Lionetti, P., Groot, P.G. de, Schultze, J.L., Netea, M.G., Kumar, V., Laat, B. de, Mmbaga, B.T., Ven, A.J. van der, Roest, M., Mast, Q. de, Temba, G.S., Vadaq, N., Wan, J., Kullaya, V., Huskens, D., Pecht, T., Jaeger, M., Boahen, C.K., Matzaraki, V., Broeders, W., Joosten, L.A.B., Faradz, S.M., Kibiki, G.S., Middeldorp, S., Cavalieri, D., Lionetti, P., Groot, P.G. de, Schultze, J.L., Netea, M.G., Kumar, V., Laat, B. de, Mmbaga, B.T., Ven, A.J. van der, Roest, M., and Mast, Q. de
- Abstract
Item does not contain fulltext, BACKGROUND: Geographic variability in coagulation across populations and their determinants are poorly understood. OBJECTIVE: To compare thrombin (TG) and plasmin (PG) generation parameters between healthy Tanzanian and Dutch individuals, and to study associations with inflammation and different genetic, host and environmental factors. METHODS: TG and PG parameters were measured in 313 Tanzanians of African descent living in Tanzania and 392 Dutch of European descent living in the Netherlands and related to results of a dietary questionnaire, circulating inflammatory markers, genotyping, and plasma metabolomics. RESULTS: Tanzanians exhibited an enhanced TG and PG capacity, compared to Dutch participants. A higher proportion of Tanzanians had a TG value in the upper quartile with a PG value in the lower/middle quartile, suggesting a relative pro-coagulant state. Tanzanians also displayed an increased normalized thrombomodulin sensitivity ratio, suggesting reduced sensitivity to protein C. In Tanzanians, PG parameters (lag time and TTP) were associated with seasonality and food-derived plasma metabolites. The Tanzanians had higher concentrations of pro-inflammatory cytokines, which correlated strongly with TG and PG parameters. There was limited overlap in genetic variation associated with TG and PG parameters between the two cohorts. Pathway analysis of genetic variants in the Tanzanian cohort revealed multiple immune pathways that were enriched with TG and PG traits, confirming the importance of co-regulation between coagulation and inflammation. CONCLUSIONS: Tanzanians have an enhanced TG and PG potential compared to Dutch individuals, which may relate to differences in inflammation, genetics and diet. These observations highlight the importance of better understanding of the geographic variability in coagulation across populations.
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- 2022
20. Food ontologies
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Tamma, V., Castellano-Escuder, Pol, González-Domínguez, Raúl, Wishart, David S, Andrés-Lacueva, Cristina, Sánchez-Pla, Alex, Snae, Chakkrit, Bruckner, Michael, Pizzuti, T., Mirabelli, G., Dragoni, M., Bailoni, Tania, Maimone, Rosa, Eccher, C., Vitali, F., Lombardo, Rosario, Rivero, Damaríz, Mattivi, F., Franceschi, P., Bordoni, A., Trimigno, Alessia, Capozzi, F., Felici, G., Taglino, F., Miglietta, F., De Cock, N., Lachat, C., De Baets, B., De Tré, G., Pinart, M., Nimptsch, K., Pischon, T., Bouwman, J., Cavalieri, D., Eftimov, T., Ispirova, Gordana, Potočnik, Doris, Ogrinc, N., Seljak, B. Koroušić, Jiomekong, Azanzi, Caracciolo, Caterina, Morshed, Ahsan, Stellato, Armando, Johannsen, Gudrun, Jaques, Yves, Keizer, Johannes, Cordier, Amélie, Dufour-Lussier, Valmi, Lieber, Jean, Nauer, Emmanuel, Badra, Fadi, Cojan, Julien, Gaillard, Emmanuelle, Infante-Blanco, Laura, Molli, Pascal, Napoli, Amedeo, Skaf-Molli, Hala, Karim, Shakir, Shaikh, Umair Uddin, Rajput, Quratulain, Asif, Zaheeruddin, Çelik, Duygu, Kolchin, Maxim, Chistyakov, A., Lapaev, Maxim, Khaydarova, R., Ibanescu, Liliana, Dibie, Juliette, Dervaux, Stéphane, Guichard, Elisabeth, Raad, Joe, Eftimov, Tome, Korošec, Peter, Seljak, Barbara Koroušić, Pizzuti, Teresa, Mirabelli, Giovanni, Grasso, Giovanni, Paldino, Giulia, Wang, Hongwei, Zhang, Fuzheng, Wang, Jialin, Zhao, Miao, Li, Wenjie, Xie, Xing, Guo, Minyi, Sherimon, Vinu, P.C, Sherimon, Ismaeel, Alaa, Varkey, Winny, B, Naveen, Padhiar, Ishita, Seneviratne, O., Chari, Shruthi, Gruen, Daniel, and McGuinness, D.
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Semantic Web - Abstract
A review of: - Methodologies, methods and tools used for the construction and evaluation of food ontologies - Integration of food ontologies in real world application to solve real world problems
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- 2022
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21. Instabilities Introduced by a Point Source on a Conical Body at Mach 6: Stability Analysis and Experimental Implementation
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Lachowicz, J. T., Cavalieri, D., Corke, T. C., Hussaini, M. Y., editor, Gatski, Thomas B., editor, and Jackson, T. L., editor
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- 1994
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22. Early melanoma invasivity correlates with gut fungal and bacterial profiles
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Vitali, F., primary, Colucci, R., additional, Di Paola, M., additional, Pindo, M., additional, De Filippo, C., additional, Moretti, S., additional, and Cavalieri, D., additional
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- 2022
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23. Indicators based on registers and administrative data for breast cancer: routine evaluation of oncologic care pathway can be implemented
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Andreano, Anita, Anghinoni, Emanuela, Autelitano, Mariangela, Bellini, Aldo, Bersani, Maurizio, Bizzoco, Sabrina, Cavalieri dʼOro, Luca, Decarli, Adriano, Lucchi, Silvia, Mannino, Salvatore, Panciroli, Emerico, Rebora, Paola, Rognoni, Magda, Sampietro, Giuseppe, Villa, Marco, Zocchetti, Carlo, Zucchi, Alberto, Valsecchi, Maria Grazia, and Russo, Antonio Giampiero
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- 2016
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24. Genomics approach to the analysis of bacterial communities dynamics in Hirschsprung’s disease-associated enterocolitis: a pilot study
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De Filippo, C., Pini-Prato, A., Mattioli, G., Avanzini, S., Rapuzzi, G., Cavalieri, D., Di Paola, M., Stefanini, I., Ceccherini, I., Mavilio, D., Lionetti, P., and Jasonni, V.
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- 2010
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25. IMPACT OF DUSP22 REARRANGEMENT ON THE PROGNOSIS OF SYSTEMIC ALK‐NEGATIVE ANAPLASTIC LARGE CELL LYMPHOMA: A LYSA AND TENOMIC STUDY
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Sibon, D, primary, Bisig, B, additional, Bonnet, C, additional, Bachy, E, additional, Cavalieri, D, additional, Fataccioli, V, additional, Drieux, F, additional, Bruneau, J, additional, Lemonnier, F, additional, Bossard, C, additional, Bouabdallah, K, additional, Parrens, M, additional, Damaj, G, additional, Tournilhac, O, additional, Jais, J. P, additional, Gaulard, P, additional, and de Leval, L, additional
- Published
- 2021
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26. MONOMORPHIC EPITHELIOTROPIC INTESTINAL T‐CELL LYMPHOMA (MEITL): CLINICO‐PATHOLOGICAL ANALYSIS OF A MULTICENTER EUROPEAN COHORT
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Cavalieri, D., primary, Tournilhac, O., additional, Missiglia, E., additional, Bonnet, C., additional, Ledoux‐Pilon, A., additional, Bisig, B., additional, Cairoli, A., additional, Poullot, E., additional, Fataccioli, V., additional, Parrens, M., additional, Copin, M. C., additional, Gutierrez, F. Llamas, additional, Xerri, L., additional, Bossard, C., additional, Wind, R., additional, Drieux, F., additional, Lhomme, F., additional, Daniel, A., additional, Clément‐Filliatre, L., additional, Lemmonier, F., additional, Morel, P., additional, Noël, R., additional, Brotelle, T., additional, Glaisner, S., additional, Sibon, D., additional, Yamani, A., additional, Bologna, S., additional, Queru, K., additional, Damaj, G., additional, Letailleur, V., additional, Villemagne, B., additional, Fleck, E., additional, Dupont, E., additional, Tchernonog, E., additional, Monjanel, H., additional, Wilde, V., additional, Vallois, D., additional, Gaulard, P., additional, and Leval, L., additional
- Published
- 2021
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27. AMAHRELIS : ADCETRIS MAINTENANCE AFTER AUTOLOGOUS STEM CELL TRANSPLANTATION IN HODGKIN LYMPHOMA : A REAL LIFE STUDY FROM SFGMTC AND LYSA GROUPS
- Author
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Marouf, A., primary, Cottereau, A. S., additional, Kanoun, S., additional, Deschamps, P., additional, Franchi, P., additional, Meignan, M., additional, Sibon, D., additional, Gastinne, T., additional, Borel, C., additional, Hammoud, M., additional, Sicard, G., additional, Gille, R., additional, Cavalieri, D., additional, Stamatoullas, A., additional, Clement, L., additional, Lazarovici, J., additional, Chauchet, A., additional, Fornecker, L. M., additional, Amorin, S., additional, Rocquet, M., additional, Raus, N., additional, Burroni, B., additional, Rubio, M. T., additional, Casasnovas, O., additional, Cartron, G., additional, Bouscary, D., additional, Brice, P., additional, Ghesquieres, H., additional, Tamburini, J., additional, and Deau, B., additional
- Published
- 2021
- Full Text
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28. The tumorigenic role of Low Molecular Weight Phosphotyrosine-Phosphatase (LMW-PTP): SW04.S17–49
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Raugei, G., Cavalieri, D., Marconi, C., Taddei, M. L., Stefanini, I., and Pietrovito, L.
- Published
- 2013
29. Manipulating human dendritic cells by STAT3 silencing to implement their use in cancer immunotherapy: CS06-1
- Author
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Sanseverino, I., Purificato, C., Conti, L., Varano, B., Beltrame, L., Cavalieri, D., Gauzzi, M. C., and Gessani, S.
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- 2011
- Full Text
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30. Final design and on-sky testing of the iLocater SX acquisition camera: broad-band single-mode fibre coupling
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Crass, J, primary, Bechter, A, additional, Sands, B, additional, King, D, additional, Ketterer, R, additional, Engstrom, M, additional, Hamper, R, additional, Kopon, D, additional, Smous, J, additional, Crepp, J R, additional, Montoya, M, additional, Durney, O, additional, Cavalieri, D, additional, Reynolds, R, additional, Vansickle, M, additional, Onuma, E, additional, Thomes, J, additional, Mullin, S, additional, Shelton, C, additional, Wallace, K, additional, Bechter, E, additional, Vaz, A, additional, Power, J, additional, Rahmer, G, additional, and Ertel, S, additional
- Published
- 2020
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31. Antarctic Sea Ice Variability and Trends, 1979-2010
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Parkinson, C. L and Cavalieri, D. J
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Meteorology And Climatology - Abstract
In sharp contrast to the decreasing sea ice coverage of the Arctic, in the Antarctic the sea ice cover has, on average, expanded since the late 1970s. More specifically, satellite passive-microwave data for the period November 1978 - December 2010 reveal an overall positive trend in ice extents of 17,100 +/- 2,300 square km/yr. Much of the increase, at 13,700 +/- 1,500 square km/yr, has occurred in the region of the Ross Sea, with lesser contributions from the Weddell Sea and Indian Ocean. One region, that of the Bellingshausen/Amundsen Seas, has, like the Arctic, instead experienced significant sea ice decreases, with an overall ice extent trend of -8,200 +/- 1,200 square km/yr. When examined through the annual cycle over the 32-year period 1979-2010, the Southern Hemisphere sea ice cover as a whole experienced positive ice extent trends in every month, ranging in magnitude from a low of 9,100 +/- 6,300 square km/yr in February to a high of 24,700 +/- 10,000 square km/yr in May. The Ross Sea and Indian Ocean also had positive trends in each month, while the Bellingshausen/Amundsen Seas had negative trends in each month, and the Weddell Sea and Western Pacific Ocean had a mixture of positive and negative trends. Comparing ice-area results to ice-extent results, in each case the ice-area trend has the same sign as the ice-extent trend, but differences in the magnitudes of the two trends identify regions with overall increasing ice concentrations and others with overall decreasing ice concentrations. The strong pattern of decreasing ice coverage in the Bellingshausen/Amundsen Seas region and increasing ice coverage in the Ross Sea region is suggestive of changes in atmospheric circulation. This is a key topic for future research.
- Published
- 2012
32. Nod2 Deficiency in mice is Associated with Microbiota Variation Favouring the Expansion of mucosal CD4+LAP+ Regulatory Cells
- Author
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Butera, A, Di Paola, M, Pavarini, L, Strati, F, Cavalieri, D, Sanchez, M, De Filippo, C, Boirivant, M, Butera A, Di Paola M, Pavarini L, Strati F, Cavalieri D, Sanchez M, De Filippo C, Boirivant M, Butera, A, Di Paola, M, Pavarini, L, Strati, F, Cavalieri, D, Sanchez, M, De Filippo, C, Boirivant, M, Butera A, Di Paola M, Pavarini L, Strati F, Cavalieri D, Sanchez M, De Filippo C, and Boirivant M
- Abstract
Nucleotide-binding Oligomerization Domain-2 (NOD2) mutations are associated with an increased risk to develop Crohn’s Disease. In previous studies, we have shown that Nod2−/− mice manifest increased proportion of Lamina Propria (LP) CD4+ LAP+ Foxp3− regulatory cells, when compared with Nod2+/+ mice, while CD4+ Foxp3 + regulatory cells were not affected. Here, we investigated the Nod2 gut microbiota, by 16S rRNA pyrosequencing, at steady state and after TNBS-colitis induction in mice reared separately or in cohousing, correlating the microbial profiles with LP regulatory T cells proportion and tissue cytokines content. We found that enrichment of Rikenella and Alistipes (Rikenellaceae) in Nod2−/− mice at 8 weeks of age reared separately was associated with increased proportion of CD4+ LAP+ Foxp3− cells and less severe TNBS-colitis. In co-housed mice the acquisition of Rickenellaceae by Nod2+/+ mice was associated with increased CD4+ LAP+ Foxp3− proportion and less severe colitis. Severe colitis was associated with enrichment of gram-negative pathobionts (Escherichia and Enterococcus), while less severe colitis with protective bacteria (Barnesiella, Odoribacter and Clostridium IV). Environmental factors acting on genetic background with different outcomes according to their impact on microbiota, predispose in different ways to inflammation. These results open a new scenario for therapeutic attempt to re-establish eubiosis in Inflammatory Bowel Disease patients with NOD2 polymorphisms.
- Published
- 2018
33. Trifluoroleucine resistance and regulation of α-isopropyl malate synthase in Saccharomyces cerevisiae
- Author
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Cavalieri, D., Casalone, E., Bendoni, B., Fia, G., Polsinelli, M., and Barberio, C.
- Published
- 1999
- Full Text
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34. A Comparison of Snow Depth on Sea Ice Retrievals Using Airborne Altimeters and an AMSR-E Simulator
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Cavalieri, D. J, Marksu, T, Ivanoff, A, Miller, J. A, Brucker, L, Sturm, M, Maslanik, J. A, Heinrichs, J. F, Gasiewski, A, Leuschen, C, Krabill, W, and Sonntag, J
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Earth Resources And Remote Sensing - Abstract
A comparison of snow depths on sea ice was made using airborne altimeters and an Advanced Microwave Scanning Radiometer for the Earth Observing System (AMSR-E) simulator. The data were collected during the March 2006 National Aeronautics and Space Administration (NASA) Arctic field campaign utilizing the NASA P-3B aircraft. The campaign consisted of an initial series of coordinated surface and aircraft measurements over Elson Lagoon, Alaska and adjacent seas followed by a series of large-scale (100 km ? 50 km) coordinated aircraft and AMSR-E snow depth measurements over portions of the Chukchi and Beaufort seas. This paper focuses on the latter part of the campaign. The P-3B aircraft carried the University of Colorado Polarimetric Scanning Radiometer (PSR-A), the NASA Wallops Airborne Topographic Mapper (ATM) lidar altimeter, and the University of Kansas Delay-Doppler (D2P) radar altimeter. The PSR-A was used as an AMSR-E simulator, whereas the ATM and D2P altimeters were used in combination to provide an independent estimate of snow depth. Results of a comparison between the altimeter-derived snow depths and the equivalent AMSR-E snow depths using PSR-A brightness temperatures calibrated relative to AMSR-E are presented. Data collected over a frozen coastal polynya were used to intercalibrate the ATM and D2P altimeters before estimating an altimeter snow depth. Results show that the mean difference between the PSR and altimeter snow depths is -2.4 cm (PSR minus altimeter) with a standard deviation of 7.7 cm. The RMS difference is 8.0 cm. The overall correlation between the two snow depth data sets is 0.59.
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- 2011
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35. Commercialanti-CD19 CART cell therapy for patients with relapsed/refractory aggressive B cell lymphoma in a European center
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Sesques, P, Ferrant, E, Safar, V, Wallet, F, Tordo, J, Dhomps, A, Karlin, L, Brisou, G, Vercasson, M, Hospital-Gustem, C, Schwiertz, V, Ranchon, F, Rioufol, C, Choquet, M, Sujobert, P, Ghergus, D, Bouafia, F, Golfier, C, Lequeu, H, Lazareth, A, Novelli, S, Devic, P, Glehen, AT, Viel, S, Venet, F, Mialou, V, Hequet, O, Chauchet, A, Arkam, Y, Nicolas-Virelizier, E, Peyrade, F, Cavalieri, D, Ader, F, Ghesquieres, H, Salles, G, and Bachy, E
- Abstract
Two autologous anti-CD19 chimeric antigen receptors (CAR) T cells (axicabtagene ciloleucel [axi-cel] and tisagenlecleucel [tisa-cel]) are commercially approved in Europe for relapsed/refractory (R/R) diffuse large B cell lymphoma (DLBCL). We performed a retrospective study to evaluate patterns of use, efficacy and safety for axi-cel and tisa-cel. Data from 70 patients who underwent apheresis for commercial CAR T cells between January 2018 and November 2019 in our institution were retrospectively collected. Sixty-one patients were infused. The median age at infusion was 59 years old (range 27-75 years). The median number of prior therapies was 3 (range, 2-6). The overall response rates (ORRs) at 1 month and 3 months were 63% and 45%, respectively, with 48% and 39% achieving a complete response (CR), respectively. After a median follow-up after infusion of 5.7 months, the median progression-free survival (PFS) was 3.0 months (95% CI, 2.8-8.8 months), and the median overall survival (OS) was 11.8 months (95% CI, 6.0-12.6 months). In multivariate analysis, factors associated with poor PFS were the number of previous lines of treatment before CAR T cells (>= 4) (P= .010) and a C reactive protein (CRP) value >30 mg/L at the time of lymphodepletion (P 30 mg/L (P= .009). Cytokine release syndrome (CRS) of any grade occurred in 85% of patients, including 8% of patients with CRS of grade 3 or higher. Immune cell-associated neurotoxicity syndrome (ICANS) of any grade occurred in 28% of patients, including 10% of patients with ICANS of grade 3 or higher. Regarding efficacy and safety, no significant difference was found between axi-cel and tisa-cel. This analysis describes one of the largest real-life cohorts of patients treated with axi-cel and tisa-cel for R/R aggressive B cell lymphoma in Europe.
- Published
- 2020
36. Comparative immunophenotyping of S.cerevisiae and Candida strains from Crohn's disease patients and their interactions with the gut microbiome
- Author
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Di Paola M., Rizzetto L., Stefanini I., Vitali F., Massi-Benedetti C., Tocci N., Romani L., Ramazzotti M., Lionetti P., De Filippo C., and Cavalieri D.
- Subjects
Crohn's disease ,gut microbiome ,Saccharomyces cerevisiae ,Candida spp - Abstract
Investigation of the fungal communities in animal models of Inflammatory Bowel Diseases (IBD) showed a controversial role of Saccharomyces cerevisiae and Candida spp. In health and disease. These conflicting observations could be ascribed to immunogenic differences among co-specific strains. To assess the relevance of intra-strains differences on yeast immunogenicity and impact on the microbiota, we screened S. cerevisiae and Candida spp. Strains isolated from fecal samples of IBD patients. We compared the cytokine profiles, obtained upon stimulation of Peripheral Blood Mononuclear Cells (PBMCs) and Dendritic Cells with different yeast strains, and evaluated the relationship between strain's cell wall sugar amount and immune response. Moreover, the gut microbiota composition was explored in relation to fungal isolation from fecal samples by metabarcoding analysis. The comparison of cytokine profiles showed strain dependent rather than species-dependent differences in immune responses. Differences in immunogenicity correlated with the cell wall composition of S. cerevisiae intestinal strains. Stimulation of human healthy PBMCs with different strains showed a pro-inflammatory IL-6 response counterbalanced by IL-10 production. Interestingly, Crohn's (CD) patients responded differently to "self" and "non-self" strains, eliciting pure Th1 or Th17 cytokine patterns. The differences observed in vitro were recapitulated in vivo, where different strains contributed in dramatically different ways to local epithelial activity and to the inflammation of wild type and Interleukin-deficient mice. Furthermore, we observed that the gut microbiota profiles significantly differentiated according to the presence of Saccharomyces or Candida spp. or the absence of fungal isolates in fecal samples. Our results show the importance to deepen metagenomics and immunophenotyping analyses to the strain level, to elucidate the role of fungal and bacterial communities in health and disease.
- Published
- 2020
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37. ERNICA guidelines for the management of rectosigmoid Hirschsprung's disease
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Kyrklund, K., Sloots, C. E. J., Blaauw, I. de, Bjørnland, K., Rolle, U., Cavalieri, D., Francalanci, P., Fusaro, F., Lemli, A., Schwarzer, N., Fascetti-Leon, F., Thapar, N., Johansen, L.S., Berrebi, D., Hugot, J.P., Crétolle, C., Brooks, A.S., Hofstra, R.M.W., Wester, T., Pakarinen, M.P., Kyrklund, K., Sloots, C. E. J., Blaauw, I. de, Bjørnland, K., Rolle, U., Cavalieri, D., Francalanci, P., Fusaro, F., Lemli, A., Schwarzer, N., Fascetti-Leon, F., Thapar, N., Johansen, L.S., Berrebi, D., Hugot, J.P., Crétolle, C., Brooks, A.S., Hofstra, R.M.W., Wester, T., and Pakarinen, M.P.
- Abstract
Contains fulltext : 225950.pdf (publisher's version ) (Open Access), BACKGROUND: Hirschsprung's disease (HSCR) is a serious congenital bowel disorder with a prevalence of 1/5000. Currently, there is a lack of systematically developed guidelines to assist clinical decision-making regarding diagnostics and management. AIMS: This guideline aims to cover the diagnostics and management of rectosigmoid HSCR up to adulthood. It aims to describe the preferred approach of ERNICA, the European Reference Network for rare inherited and congenital digestive disorders. METHODS: Recommendations within key topics covering the care pathway for rectosigmoid HSCR were developed by an international workgroup of experts from 8 European countries within ERNICA European Reference Network from the disciplines of surgery, medicine, histopathology, microbiology, genetics, and patient organization representatives. Recommendation statements were based on a comprehensive review of the available literature and expert consensus. AGREE II and GRADE approaches were used during development. Evidence levels and levels of agreement are noted. RESULTS: Thirty-three statements within 9 key areas were generated. Most recommendations were based on expert opinion. CONCLUSION: In rare or low-prevalence diseases such as HSCR, there remains limited availability of high-quality clinical evidence. Consensus-based guidelines for care are presented.
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- 2020
38. ERNICA guidelines for the management of rectosigmoid Hirschsprung's disease
- Author
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Kyrklund, K, Sloots, C.E.J., de Blaauw, I, Bjornland, K, Rolle, U, Cavalieri, D, Francalanci, P, Fusaro, F, Lemli, A, Schwarzer, N, Fascetti-Leon, F, Thapar, N, Johansen, LS, Berrebi, D, Hugot, JP, Cretolle, C, Brooks, Alice, Hofstra, Robert, Wester, T, Pakarinen, MP, Kyrklund, K, Sloots, C.E.J., de Blaauw, I, Bjornland, K, Rolle, U, Cavalieri, D, Francalanci, P, Fusaro, F, Lemli, A, Schwarzer, N, Fascetti-Leon, F, Thapar, N, Johansen, LS, Berrebi, D, Hugot, JP, Cretolle, C, Brooks, Alice, Hofstra, Robert, Wester, T, and Pakarinen, MP
- Published
- 2020
39. Microwave Signatures of Snow on Sea Ice: Modeling
- Author
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Powell, D. C, Markus, T, Cavalieri, D. J, Gasiewski, A. J, Klein, M, Maslanik, J. A, Stroeve, J. C, and Sturm, M
- Subjects
Meteorology And Climatology - Abstract
Accurate knowledge of snow-depth distribution over sea ice is critical for polar climate studies. Current snow-depth-over-sea-ice retrieval algorithms do not sufficiently account for variations in snow and ice physical properties that can affect the accuracy of retrievals. For this reason, airborne microwave observations were coordinated with ground-based measurements of snow depth and snow properties in the vicinity of Barrow, AK, in March 2003. In this paper, the effects of snowpack properties and ice conditions on microwave signatures are examined using detailed surface-based measurements and airborne observations in conjunction with a thermal microwave-emission model. A comparison of the Microwave Emission Model of Layered Snowpacks (MEMLS) simulations with detailed snowpack and ice data from stakes along the Elson Lagoon and the Beaufort Sea and ra- 'diometer data taken from low-level flights using a Polarimetric Scanning Radiometer (PSR-A) shows that MEMLS can be used to simulate snow on sea ice and is a useful tool for understanding the limitations of the snow-depth algorithm. Analysis of radiance data taken over the Elson Lagoon and the Beaufort Sea using MEMLS suggests that the radiometric differences between the two locations are due to the differences in sea-ice emissivity. Furthermore, measured brightness temperatures suggest that the current snow-depth retrieval algorithm is sufficient for areas of smooth first-year sea ice, whereas new algorithm coefficients are needed for rough first-year sea ice. Snowpack grain size and density remain an unresolved issue for snow-depth retrievals using passive-microwave radiances.
- Published
- 2006
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- View/download PDF
40. EOS Aqua AMSR-E Arctic Sea-Ice Validation Program: Arctic2006 Aircraft Campaign Flight Report
- Author
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Cavalieri, D. J and Markus, T
- Subjects
Geosciences (General) - Abstract
In March 2006, a coordinated Arctic sea-ice validation field campaign using the NASA Wallops P-3B aircraft was successfully completed. This campaign was the second Alaskan Arctic field campaign for validating the Earth Observing System (EOS) Aqua Advanced Microwave Scanning Radiometer (AMSR-E) sea-ice products. The first campaign was completed in March 2003. The AMSR-E, designed and built by the Japanese Space Agency for NASA, was launched May 4, 2002 on the EOS Aqua spacecraft. The AMSR-E sea-ice products to be validated include sea-ice concentration, sea-ice temperature, and snow depth on sea ice. The focus of this campaign was on the validation of snow depth on sea ice and sea-ice temperature. This flight report describes the suite of instruments flown on the P-3, the objectives of each of the six flights, the Arctic regions overflown, and the coordination among satellite, aircraft, and surface-based measurements.
- Published
- 2006
41. Interannual and Regional Variability of Southern Ocean Snow on Sea Ice and its Correspondence with Sea Ice Cover and Atmospheric Circulation Patterns
- Author
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Markus, T and Cavalieri, D. J
- Subjects
Meteorology And Climatology - Abstract
Snow depth on sea ice plays a critical role in the heat exchange between ocean and atmosphere because of its thermal insulation property. Furthermore, a heavy snow load on the relatively thin Southern Ocean sea-ice cover submerges the ice floes below sea level, causing snow-to-ice conversion. Snowfall is also an important freshwater source into the weakly stratified ocean. Snow depth on sea-ice information can be used as an indirect measure of solid precipitation. Satellite passive microwave data are used to investigate the interannual and regional variability of the snow cover on sea ice. In this study we make use of 12 years (1992-2003) of Special Sensor Microwave/Imager (SSM/I) radiances to calculate average monthly snow depth on the Antarctic sea-ice cover. The results show a slight increase in snow depth and a partial eastward propagation of maximum snow depths, which may be related to the Antarctic Circumpolar Wave.
- Published
- 2006
42. Earth Observing System (EOS) Snow and Ice Products for Observation and Modeling
- Author
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Hall, D, Kaminski, M, Cavalieri, D, Dickinson, R, Marquis, M, Riggs, G, Robinson, D, VanWoert, M, and Wolfe, R
- Subjects
Earth Resources And Remote Sensing - Abstract
Snow and ice are the key components of the Earth's cryosphere, and their influence on the Earth's energy balance is very significant due at least in part to the large areal extent and high albedo characterizing these features. Large changes in the cryosphere have been measured over the last century and especially over the past decade, and remote sensing plays a pivotal role in documenting these changes. Many of NASA's Earth Observing System (EOS) products derived from instruments on the Terra, Aqua, and Ice, Cloud and land Elevation Satellite (ICESat) satellites are useful for measuring changes in features that are associated with climate change. The utility of the products is continually enhanced as the length of the time series increases. To gain a more coherent view of the cryosphere and its historical and recent changes, the EOS products may be employed together, in conjunction with other sources of data, and in models. To further this goal, the first EOS Snow and Ice Products Workshop was convened. The specific goals of the workshop were to provide current and prospective users of EOS snow and ice products up-to-date information on the products, their validation status and future enhancements, to help users utilize the data products through hands-on demonstrations, and to facilitate the integration of EOS products into models. Oral and poster sessions representing a wide variety of snow and ice topics were held; three panels were also convened to discuss workshop themes. Panel discussions focused on data fusion and assimilation of the products into models. Approximately 110 people attended, representing a wide array of interests and organizations in the cryospheric community.
- Published
- 2005
43. EOS Aqua AMSR-E Arctic Sea Ice Validation Program
- Author
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Cavalieri, D. J, Markus, T, Gasiewski, A, Klein, M, Maslanik, J, Sturm, M, Stroeve, J, and Heinrichs, J
- Subjects
Oceanography - Abstract
A coordinated Arctic sea ice validation field campaign using the NASA Wallops P-3B aircraft was successfully completed in March 2003. This campaign was part of the program for validating the Earth Observing System (EOS) Aqua Advanced Microwave Scanning Radiometer (AMSR-E) sea ice products. The AMSR-E, designed and built by the Japanese National Space Development Agency for NASA, was launched May 4,2002 on the EOS Aqua spacecraft. The AMSR-E sea ice products include sea ice concentration, sea ice temperature, and snow depth on sea ice. The primary instrument on the P-3B aircraft was the NOAA ETL Polarimetric Scanning Radiometer (PSR) covering the same frequencies and polarizations as the AMSR-E. This paper describes the objectives of each of the seven flights, the Arctic regions overflown, and the coordination among satellite, aircraft, and surface-based measurements. Two of the seven aircraft flights were coordinated with scientists making surface measurements of snow and ice properties including sea ice temperature and snow depth on sea ice at a study area near Barrow, AK and at a Navy ice camp located in the Beaufort Sea. The remaining flights covered portions of the Bering Sea ice edge, the Chukchi Sea, and Norton Sound. Comparisons among the satellite and aircraft PSR data sets are presented.
- Published
- 2004
44. EOS Aqua AMSR-E Arctic Sea Ice Validation Program: Intercomparison Between Modeled and Measured Sea Ice Brightness Temperatures
- Author
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Stroeve, J, Markus, T, Cavalieri, D. J, Maslanik, J, Sturm, M, Henrichs, J, Gasiewski, A, and Klein, M
- Subjects
Earth Resources And Remote Sensing - Abstract
During March 2003, an extensive field campaign was conducted near Barrow, Alaska to validate AQUA Advanced Microwave Scanning Radiometer (AMSR) sea ice products. Field, airborne and satellite data were collected over three different types of sea ice: 1) first year ice with little deformation, 2) first year ice with various amounts of deformation and 3) mixed first year ice and multi-year ice with various degrees of deformation. The validation plan relies primarily on comparisons between satellite, aircraft flights and ground-based measurements. Although these efforts are important, key aspects such as the effects of atmospheric conditions, snow properties, surface roughness, melt processes, etc on the sea ice algorithms are not sufficiently well understood or documented. To improve our understanding of these effects, we combined the detailed, in-situ data collection from the 2003 field campaign with radiance modeling using a radiative transfer model to simulate the top of the atmosphere AMSR brightness temperatures. This study reports on the results of the simulations for a variety of snow and ice types and compares the results with the National Oceanographic and Atmospheric Administration Environmental Technology Laboratory Polarimetric Scanning Radiometer (NOAA) (ETL) (PSR) microwave radiometer that was flown on the NASA P-3.
- Published
- 2004
45. EOS Aqua AMSR-E Arctic Sea Ice Validation Program: Arctic2003 Aircraft Campaign Flight Report
- Author
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Cavalieri, D. J and Markus,T
- Subjects
Earth Resources And Remote Sensing - Abstract
In March 2003 a coordinated Arctic sea ice validation field campaign using the NASA Wallops P-3B aircraft was successfully completed. This campaign was part of the program for validating the Earth Observing System (EOS) Aqua Advanced Microwave Scanning Radiometer (AMSR-E) sea ice products. The AMSR-E, designed and built by the Japanese National Space Development Agency for NASA, was launched May 4, 2002 on the EOS Aqua spacecraft. The AMSR-E sea ice products to be validated include sea ice concentration, sea ice temperature, and snow depth on sea ice. This flight report describes the suite of instruments flown on the P-3, the objectives of each of the seven flights, the Arctic regions overflown, and the coordination among satellite, aircraft, and surface-based measurements. Two of the seven aircraft flights were coordinated with scientists making surface measurements of snow and ice properties including sea ice temperature and snow depth on sea ice at a study area near Barrow, AK and at a Navy ice camp located in the Beaufort Sea. Two additional flights were dedicated to making heat and moisture flux measurements over the St. Lawrence Island polynya to support ongoing air-sea-ice processes studies of Arctic coastal polynyas. The remaining flights covered portions of the Bering Sea ice edge, the Chukchi Sea, and Norton Sound.
- Published
- 2003
46. 30-Year Satellite Record Reveals Contrasting Arctic and Antarctic Decadal Sea Ice Variability
- Author
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Cavalieri, D. J, Parkinson, C. L, and Vinnikov, K. Y
- Subjects
Geophysics - Abstract
A 30-year satellite record of sea ice extents derived mostly from satellite microwave radiometer observations reveals that the Arctic sea ice extent decreased by 0.30+0.03 x 10(exp 6) square kilometers per 10 yr from 1972 through 2002, but by 0.36 plus or minus 0.05 x 10(exp 6) square kilometers per 10yr from 1979 through 2002, indicating an acceleration of 20% in the rate of decrease. In contrast, the Antarctic sea ice extent decreased dramatically over the period 1973-1977, then gradually increased. Over the full 30-year period, the Antarctic ice extent decreased by 0.15 plus or minus 0.08 x 10(exp 6) square kilometers per 10 yr. The trend reversal is attributed to a large positive anomaly in Antarctic sea ice extent in the early 1970's, an anomaly that apparently began in the late 1960's, as observed in early visible and infrared satellite images.
- Published
- 2003
47. New evidences on the altered gut microbiota in autism spectrum disorders
- Author
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Strati, F, Cavalieri, D, Albanese, D, De Felice, C, Donati, C, Hayek, J, Jousson, O, Leoncini, S, Renzi, D, Calabrò, A, De Filippo, C, Strati, Francesco, Cavalieri, D., Albanese, Davide, De Felice, C., Donati, Claudio, Hayek, J., Jousson, O., Leoncini, S., Renzi, D., Calabrò, A., De Filippo, C., Strati, F, Cavalieri, D, Albanese, D, De Felice, C, Donati, C, Hayek, J, Jousson, O, Leoncini, S, Renzi, D, Calabrò, A, De Filippo, C, Strati, Francesco, Cavalieri, D., Albanese, Davide, De Felice, C., Donati, Claudio, Hayek, J., Jousson, O., Leoncini, S., Renzi, D., Calabrò, A., and De Filippo, C.
- Abstract
Background: Autism spectrum disorders (ASDs) are neurodevelopmental conditions characterized by social and behavioural impairments. In addition to neurological symptoms, ASD subjects frequently suffer from gastrointestinal abnormalities, thus implying a role of the gut microbiota in ASD gastrointestinal pathophysiology. Results: Here, we characterized the bacterial and fungal gut microbiota in a cohort of autistic individuals demonstrating the presence of an altered microbial community structure. A fraction of 90% of the autistic subjects were classified as severe ASDs. We found a significant increase in the Firmicutes/Bacteroidetes ratio in autistic subjects due to a reduction of the Bacteroidetes relative abundance. At the genus level, we observed a decrease in the relative abundance of Alistipes, Bilophila, Dialister, Parabacteroides, and Veillonella in the ASD cohort, while Collinsella, Corynebacterium, Dorea, and Lactobacillus were significantly increased. Constipation has been then associated with different bacterial patterns in autistic and neurotypical subjects, with constipated autistic individuals characterized by high levels of bacterial taxa belonging to Escherichia/Shigella and Clostridium cluster XVIII. We also observed that the relative abundance of the fungal genus Candida was more than double in the autistic than neurotypical subjects, yet due to a larger dispersion of values, this difference was only partially significant. Conclusions: The finding that, besides the bacterial gut microbiota, also the gut mycobiota contributes to the alteration of the intestinal microbial community structure in ASDs opens the possibility for new potential intervention strategies aimed at the relief of gastrointestinal symptoms in ASDs.
- Published
- 2017
48. Metagenomic characterisation of gut microbiota in IBS patients
- Author
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SCIAVILLA, PIERO, MODESTO, MONICA MARIANNA, LUISELLI, DONATA, MATTARELLI, PAOLA, Strati, F., Prati, G. M., Fornari, F., Cavalieri, D., De Filippo, C., Sciavilla, P, Strati, F, Prati, G, Fornari, F, Modesto, M, Luiselli, D, Cavalieri, D, De Filippo, C, Mattarelli, P, Sciavilla, P., Strati, F., Prati, G.M., Fornari, F., Modesto, M., Luiselli, D., Cavalieri, D., De Filippo, C., and Mattarelli, P.
- Subjects
IBS, gut microbiome ,IBS, microbiota, mycobiota, Candida, metagenimics - Abstract
Introduction: Irritable Bowel Syndrome (IBS) is a gastrointestinal (GI) disorder that exhibits different GI and neurological symptoms such as abdominal pain, diarrhoea, constipation and mood disorders. The gut microbiota play an important role in modulating the communication between the Central Nervous System (CNS) and the GI tract, the so-called microbiota-gut-brain axis. In this context, IBS is a clear example of the alteration of the fine equilibrium between the gut microbiota and the CNS. Furthermore it has been observed that probiotic treatments of IBS results in the relief of GI and neurological symptoms, thus we could hypothesize the direct impact of the gut microbiota on IBS physiopathology. Since the IBS bacterial gut microbiota has been extensively studied we focused our attention also on the fungal counterpart of the gut microbiota, "the mycobiota". Methods and aims. The aim of the present work was to evaluate biodiversity in bacterial and fungal microbiota of a cohort of 20 IBS subject and 21 healthy subject (HS) through culture-based and metagenomics approaches. The bacterial diversity that relies on DNA polymorphism has been performed by means of cluster analysis of ARDRA profiles. Moreover the absolute abundances of bifidobacteria and enterobacteria has been evaluated by qPCR. For IBS gut mycobiota characterization, fungal strains from IBS stool samples were isolated and identified by mean of ITS1-4 sequencing. Furthermore, isolates were phenotypically characterized to evaluate their resistance to GI tract stresses (temperature, low pH and oxbile resistance), while Candida isolates were further clustered by means of their RAPD profiles. Results: The cluster analysis of ARDRA profiles showed that IBS bacterial microbiota clusters apart from HS microbiota. In addition we observed a 2.8-fold increase in the absolute abundance of enterobacteria in IBS subjects vs HS. The analysis of the gut mycobiota revealed significant differences in fungal isolates abundance in IBS subjects vs HS even if we did not find any significant difference in species richness. In particular, results showed an abundance of fungi (61.8% C. albicans), with a higher number of colony count 4.7 log10 CFU/g faeces in IBS subjects respect to HS faecal samples with 1.9 log10 CFU/g (48,75% C. albicans). RAPD prolfile analysis of C. albicans and C. parapsilosis showed that IBS isolates clustered apart from HS isolates, suggesting their different genotypical background. Finally, we observed that IBS fungal isolates showed different phenotypical features with an increased ability to growth to high temperatures and low pH respect to isolates from HS. Conclusions: Our results showed the presence of alterations in the microbial community structure of IBS subjects, both at bacterial and fungal level. The absolute abundance of enterobacteria in IBS subjects suggests their connection with putative inflammatory phenomena as previously observed in IBS and other pathologies (Lee and Park, 2014). The phenotypical characterization of IBS fungal isolates revealed that such isolates showed a different response in respect GI-like stresses. Moreover we observed that C. albicans and C. parapsilosis isolates from IBS are both phenotypically and genotypically different from HS Candida isolates suggesting their putative different ecological distribution. Finally we could hypotesize that dysbiosis of the gut microbiota in IBS could be one of the driving factor in IBS pathophysiology that could be responsible of intestinal fungal population overgrowth. Lee JY, Park KS. 2014. World J Gastroenterol 20:2456-2469
- Published
- 2016
49. Arctic Climate and Atmospheric Planetary Waves
- Author
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Cavalieri, D. J, Haekkinen, S, and Zukor, Dorothy J
- Subjects
Meteorology And Climatology - Abstract
Analysis of a fifty-year record (1946-1995) of monthly-averaged sea level pressure data provides a link between the phases of planetary-scale sea level pressure waves and Arctic Ocean and ice variability. Results of this analysis show: (1) a breakdown of the dominant wave 1 pattern in the late 1960's, (2) shifts in the mean phase of waves 1 and 2 since this breakdown, (3) an eastward shift in the phases of both waves 1 and 2 during the years of simulated cyclonic Arctic Ocean circulation relative to their phases during the years of anticyclonic circulation, (4) a strong decadal variability of wave phase associated with simulated Arctic Ocean circulation changes. Finally, the Arctic atmospheric circulation patterns that emerge when waves 1 and 2 are in their extreme eastern and western positions suggest an alternative approach for determining significant forcing patterns of sea ice and high-latitude variability.
- Published
- 2001
50. Instabilities Introduced by a Point Source on a Conical Body at Mach 6: Stability Analysis and Experimental Implementation
- Author
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Lachowicz, J. T., primary, Cavalieri, D., additional, and Corke, T. C., additional
- Published
- 1994
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