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18 results on '"Cavanaugh, Jie Y."'

3. XBridge[TM] prep columns: scalability and loadability for preparative separations: BEH Technology[TM], the second generation of patented organic-inorganic hybrid particle technology (HPT), is the new benchmark for HPLC columns. Waters XBridge[TM] Prep columns reach a new level of maximum loadability and direct scalability

Author

Xia, Fang, Cavanaugh, Jie Y., and Diehl, Diane M.

Subjects
Waters Corp., Instrument industry
Abstract

XBridge[TM] columns were designed to be the most pH-stable phases commercially available, while still providing maximum efficiency, peak shape, and robustness. For method development consideration, we offer [C.sub.18], [C.sub.8], phenyl [...]

Published
2005

4. Separation of synthetic peptides on a preparative RPLC column

Author

Xia, Fang, Ren, Da, Cavanaugh, Jie Y., Gilar, Martin, Fountain, Kenneth J., and Diehl, Diane M.

Abstract

Crude synthetic peptide samples were separated on preparative Atlantis[TM] [dC.sub.18] columns. Fraction collection was triggered by the mass-to-charge (m/z) ratio of the peptides, which specified the target peptide in the [...]

Published
2004

5. Separation and purification of polar compounds on a reversed-phase preparative column: are you thinking about Atlantis[TM] [dC.sub.18]?

Author

Xia, Fang, Cavanaugh, Jie Y., Diehl, Diane M., Morrison, Damian, McCabe, Douglas R., and Mazzeo, Jeffrey R.

Abstract

Atlantis[TM] [dC.sub.18] columns are a fully LC/MS compatible line of reversed-phased (RP) columns designed for retaining and separating both polar and non-polar compounds. This new silica-based packing material has excellent [...]

Published
2003

6. Seamless method transfer from UPLC technology to preparative LC

Author

Xia, Fang, Cavanaugh, Jie Y., Diehl, Diane M., Wheat, Thomas E., and Mazzeo, Jeffrey R.

Subjects
Waters Corp. -- Technology application, Instrument industry -- Technology application -- Methods, Technology application, Chemistry, Science and technology
Abstract

Scale-up from UPLC technology to preparative LC is readily achieved using preparative OBD columns and typical scaling equations and principles. UltraPerformance LC (UPLC) has been widely accepted by chromatographers because [...]

Published
2007

7. Preparative purification of challenging basic compounds: what are the options?

Author

Xia, Fang, Cavanaugh, Jie Y., and Diehl, Diane M.

Subjects
Chromatography -- Research
Abstract

The new reversed-phased SunFire[TM] [C.sub.18] column possesses high preparative mass loading and excellent efficiency for challenge separations under low pH conditions. ********** Structurally related analytes are challenging to purify efficiently [...]

Published
2004

9. Seamless method transfer from UPLC technology to preparative LC

Author

Zia, Fang, Cavanaugh, Jie Y., Diehl, Diane M., Wheat, Thomas E., and Mazzeo, Jeffrey R.

Subjects
Waters Corp. -- Product information, Instrument industry -- Product information, Liquid chromatography -- Product information, Chemistry, Science and technology
Abstract

The features of Waters Corporation's ultraperformance liquid chromatography are presented.

Published
2007

11. SunFire[TM] [C.sub.18]: a unique RPLC stationary phase for higher loading and improved peak shapes: the new SunFire[TM] [C.sub.18] columns are reversed-phase HPLC columns designed for high preparative mass loading, excellent efficiency and peak shapes, and stability under low pH conditions

Author

Xia, Fang, Cavanaugh, Jie Y., and Diehl, Diane M.

Abstract

Today's chromatographers often struggle with tailing peaks that limit resolution and mass loading. High silanol activity contributes significantly to peak tailing in reversed phase liquid chromatography (RPLC) columns. Other factors, [...]

Published
2004

12. Separation and Purification of Highly Polar Pharmaceutical Compounds on a RPLC Column at Prep Scale: Are You Thinking about Atlantis™ dC18?

Author

Fang Xia, Cavanaugh, Jie Y., Diehl, Diane M., Morrison, Damian, McCabe, Douglas R., and Mazzero, Jeffrey R.

Subjects
*MACHINE separators, *CHEMICAL purification, *HIGH throughput screening (Drug development), *CHEMICAL engineering equipment, *PHARMACEUTICAL chemistry
Abstract

Features the Atlantis™ dC18 columns developed by Waters Corp. in Milford, Massachusetts. Use of the device in the separation and purification of highly polar pharmaceutical compounds; Stability of the new silica-based packing material in acidic mobile phases; Advantages of using the novel device over the traditional reverse phase columns.

Published
2003

13. Separation and Purification of Highly Polar Pharmaceutical Compounds on a RPLC Column at Prep Scale: Are You Thinking about Atlantis™ dC[sub18]?

Author

Xia, Fang, Cavanaugh, Jie Y., Diehl, Diane M., Morrison, Damian, McCabe, Douglas R., and Mazzeo, Jeffrey R.

Subjects
*CHROMATOGRAPHIC analysis, *SEPARATION (Technology), *CHEMICAL purification, *SULFONAMIDES, *ANALYTICAL chemistry, *INDUSTRIAL chemistry
Abstract

Demonstrates the utility of Atlantis dC[sub 18] columns via the separation and purification of three mixtures of polar compounds. Experimental conditions; Description of Atlantis dC[sub 18] reversed-phase columns; Retention and separation of the sulphonamides on the analytical column.

Published
2003

14. Separation and Purification of Highly Polar Pharmaceutical Compounds on a RPLC Column at Prep Scale: Are You Thinking about Atlantis™ dC18?

Author

Fang Xia, Cavanaugh, Jie Y., Diehl, Diane M., Morrison, Damian, McCabe, Douglas R., and Mazzero, Jeffrey R.

Subjects
MACHINE separators, CHEMICAL purification, HIGH throughput screening (Drug development), CHEMICAL engineering equipment, PHARMACEUTICAL chemistry
Abstract

Features the Atlantis™ dC18 columns developed by Waters Corp. in Milford, Massachusetts. Use of the device in the separation and purification of highly polar pharmaceutical compounds; Stability of the new silica-based packing material in acidic mobile phases; Advantages of using the novel device over the traditional reverse phase columns.

Published
2003

15. XBridge Prep Columns: Scalability and Loadability for Preparative Separations.

Author

Fang Xia, Cavanaugh, Jie Y., and Drehl, Diane M.

Subjects
*HIGH performance liquid chromatography, *LIQUID chromatography, *SEPARATION (Technology), *TECHNOLOGY, *CHROMATOGRAPHIC analysis, *PHASE partition
Abstract

BEH Technology™, the second generation of patented organic/inorganic hybrid particle technology (HPT), is the new benchmark for HPLC columns. Waters XBridge™ Prep columns reach a new level of maximum loadability and direct scalability. [ABSTRACT FROM AUTHOR]

Published
2005

16. Bridging the Performance Gap from Analytical to Preparative Chromatography: Efficient Target Isolation from a Complex Mixture.

Author

Fang Xia, Cavanaugh, Jie Y., and Diehl, Diane M.

Subjects
*CHROMATOGRAPHIC analysis, *ANALYTICAL chemistry, *PHASE partition, *SCALABILITY, *SYSTEMS design, *COMPUTER networks
Abstract

SunFire™ C18 analytical and OBD™ preparative columns are designed to provide maximum loadability in simple mobile-phase conditions, accurate scalability and high peak capacity. [ABSTRACT FROM AUTHOR]

Published
2005

17. Seamless Method Transfer from UPLC Technology to Preparative LC.

Author

Fang Xia, Cavanaugh, Jie Y., Diehl, Diane M., Wheat, Thomas E., and Mazzeo, Jeffrey R.

Subjects
*CHROMATOGRAPHIC analysis, *LIQUID chromatography, *SEPARATION (Technology), *ANALYTICAL chemistry, *PHASE partition
Abstract

The article presents an application note about the seamless method transfer from UltraPerformance Liquid Chromatography technology to preparative LC. According to the authors, this method transfer can be achieved using the Preparative OBD columns and typical scaling equations and principles. Materials and method used, results and discussion, and the conclusion are presented.

Published
2007

18. Separation and Purification of Polar Compounds on a Reversed-Phase Preparative Column: Are You Thinking about Atlantis™ dC[sub18]?

Author

Fang Xia, Cavanaugh, Jie Y., Diehl, Diane M., Morisson, Damian, McCabe, Douglas R., and Mazzeo, Jeffrey R.

Subjects
*CHROMATOGRAPHIC analysis equipment, *SEPARATION (Technology), *CHEMICAL purification
Abstract

Demonstrates the utility of the Atlantis dC[sub18] columns from the Waters Corp. Design of the Atlantis material to combine pore size, ligand density and ligand type to retain polar analytes and operate in aqueous conditions; Development of polar mixture separations on analytic dimension Atlantis columns; Separation preparation for purification of compounds; Tool effectiveness for separating polar compounds.

Published
2003

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