Search

Your search keyword '"Cazzoletti, L"' showing total 142 results
Start Over Author "Cazzoletti, L"
142 results on '"Cazzoletti, L"'

6. The socio-economic burden of asthma is substantial in Europe

Author

Accordini, S., Corsico, A., Cerveri, I., Gislason, D., Gulsvik, A., Janson, C., Jarvis, D., Marcon, A., Pin, I., Vermeire, P., Almar, E., Bugiani, M., Cazzoletti, L., Duran-Tauleria, E., Jõgi, R., Marinoni, A., Martínez-Moratalla, J., Leynaert, B., and de Marco, R.

Published
2008

8. Determinants of fractional exhaled nitric oxide in healthy men and women from the European Community Respiratory Health Survey III

Author

Nerpin, E., Olivieri, M., Gislason, T., Olin, A. C., Nielsen, R., Johannessen, A., Ferreira, D. S., Marcon, A., Cazzoletti, L., Accordini, S., Pin, I., Corsico, A., Demoly, P., Weyler, J., Nowak, D., Jõgi, R., Forsberg, Bertil, Zock, J.P., Sigsgaard, T., Heinric, J., Bono, R., Leynaert, B., Jarvis, D., Janson, C., Malinovschi, A., Nerpin, E., Olivieri, M., Gislason, T., Olin, A. C., Nielsen, R., Johannessen, A., Ferreira, D. S., Marcon, A., Cazzoletti, L., Accordini, S., Pin, I., Corsico, A., Demoly, P., Weyler, J., Nowak, D., Jõgi, R., Forsberg, Bertil, Zock, J.P., Sigsgaard, T., Heinric, J., Bono, R., Leynaert, B., Jarvis, D., Janson, C., and Malinovschi, A.

Abstract

Introduction: The fractional exhaled nitric oxide (FENO) is a marker for type 2 inflammation used in diagnostics and management of asthma. In order to use FENO as a reliable biomarker, it is important to investigate factors that influence FENO in healthy individuals. Men have higher levels of FENO than women, but it is unclear whether determinants of FENO differ by sex. Objective: To identify determinants of FENO in men and women without lung diseases. Method: FENO was validly measured in 3,881 healthy subjects that had answered the main questionnaire of the European Community Respiratory Health Survey III without airways or lung disease Results: Exhaled NO levels were 21.3% higher in men compared with women p<0.001. Being in the upper age quartile (60.3–67.6 years) men had 19.2 ppb (95% CI: 18.3, 20.2) higher FENO than subjects in the lowest age quartile (39.7–48.3 years) p=0.02. Women in the two highest age quartiles (54.6–60.2 and 60.3–67.6 years) had 15.4 ppb (14.7, 16.2), p=0.03 and 16.4 ppb (15.6, 17.1), p=<0.001 higher FENO, compared with the lowest age quartile. Height was related to 8% higher FENO level in men (p<0.001) and 5% higher FENO levels in women (p=0.008). Men who smoked had 37% lower FENO levels and women had 30% lower levels compared with never‐smokers (p<0.001 for both). Men and women sensitized to both grass and perennial allergens had higher FENO levels compared with non‐sensitized subjects 26% and 29%, p<0.001 for both. Conclusion & Clinical Relevance: FENO levels were higher in men than women. Similar effects of current smoking, height, and IgE sensitization were found in both sexes. FENO started increasing at lower age in women than in men, suggesting that interpretation of FENO levels in adults aged over 50 years should take into account age and sex.

Published
2019
Full Text
View/download PDF

10. M8 Cost variations of asthma over 10 years in adults

Author

Portas, L, primary, Calciano, L, additional, Corsico, AG, additional, Cazzoletti, L, additional, Cerveri, I, additional, Gerbase, MW, additional, Gislason, D, additional, Gronseth, R, additional, Heinrich, J, additional, Jögi, R, additional, Johannessen, A, additional, Marcon, A, additional, Pin, I, additional, Wacker, M, additional, Jarvis, D, additional, Janson, C, additional, and Accordini, S, additional

Published
2018
Full Text
View/download PDF

11. Trends in the prevalence of asthma and allergic rhinitis in Italy between 1991 and 2010

Author

de Marco R, Cappa V, Accordini S, Rava M, Antonicelli L, Bortolami O, Braggion M, Bugiani M, Casali L, Cazzoletti L, Cerveri I, Fois AG, Girardi P, Locatelli F, Marcon A, Marinoni A, Panico MG, Pirina P, Villani S, Zanolin ME, Verlato G, the GEIRD Study Group: de Marco, R., Verlato, G., Zanolin, M., Accordini, S., Bortolami, O., Braggion, M., Cappa, V., Cazzoletti, L., Girardi, P., Locatelli, F., Marcon, A., Montoli, E., Rava, M., Vesentini, R., Ferrari, M., Donatelli, L., Posenato, C., Cascio, V., Perbellini, L., Olivieri, M., D'Amato, J., Donatini, E., Martinelli, M., Pignatti, P., Bombieri, C., Bettin, M., Trabetti, E., Poli, A., Nicolis, M., Sembeni, S., Antonicelli, L., Bonifazi, F., Attena, F., Galdo, V., Cerveri, I., Corsico, A., Albicini, F., Grosso, A., Marinoni, A., Villani, S., Ferretti, V., Casali, L., Miniucchi, A., Briziarelli, L., Marcarelli, M., Panico, M., Pirina, P., Fois, A., Becciu, F., Deledda, A., Spada, V., Bugiani, M., Carosso, A., Piccioni, P., Castiglioni, G., Bono, R., Tassinari, R., Romanazzi, V., Rolla, G., Heffler, E., Migliore, E., BELLIA, Vincenzo, BATTAGLIA, Salvatore, de Marco R, Cappa V, Accordini S, Rava M, Antonicelli L, Bortolami O, Braggion M, Bugiani M, Casali L, Cazzoletti L, Cerveri I, Fois AG, Girardi P, Locatelli F, Marcon A, Marinoni A, Panico MG, Pirina P, Villani S, Zanolin ME, Verlato G, and the GEIRD Study Group: de Marco, R., Verlato, G., Zanolin, M., Accordini, S., Bortolami, O., Braggion, M., Cappa, V., Cazzoletti, L., Girardi, P., Locatelli, F., Marcon, A., Montoli, E., Rava, M., Vesentini, R., Ferrari, M., Donatelli, L., Posenato, C., Cascio, V., Perbellini, L., Olivieri, M., D'Amato, J., Donatini, E., Martinelli, M., Pignatti, P., Bombieri, C., Bettin, M., Trabetti, E., Poli, A., Nicolis, M., Sembeni, S., Antonicelli, L., Bonifazi, F., Attena, F., Galdo, V., Bellia, V., Battaglia, S., Cerveri, I., Corsico, A., Albicini, F., Grosso, A., Marinoni, A., Villani, S., Ferretti, V., Casali, L., Miniucchi, A., Briziarelli, L., Marcarelli, M., Panico, M., Pirina, P., Fois, A., Becciu, F., Deledda, A., Spada, V., Bugiani, M., Carosso, A., Piccioni, P., Castiglioni, G., Bono, R., Tassinari, R., Romanazzi, V., Rolla, G., Heffler, E., and Migliore, E.

Subjects
Male, Pediatrics, Cross-sectional study, 95% CI 1.19-1.59) from 1998-2000 to 2007-2010, but since then there has been no clear temporal pattern. The present study aimed to assess time trends in the prevalence of current asthma, Abstract The prevalence of asthma increased worldwide until the 1990s, temporal trends, Surveys and Questionnaires, Epidemiology, Surveys and Questionnaire, Medicine, asthma-like symptoms and allergic rhinitis in Italian adults from 1990 to 2010. The same screening questionnaire was administered by mail or phone to random samples of the general population (age 20-44 yrs) in Italy, Young adult, respectively. The prevalence of current asthma was stable during the 1990s and increased (relative risk 1.38, from 10.1% to 13.9% and from 16.8% to 25.8%, education.field_of_study, Allergic rhinitis, Asthma, Prevalence, Temporal trends, Wheezing, medicine.diagnostic_test, Smoking, the median prevalence of current asthma, allergic rhinitis, asthma, epidemiology, prevalence, temporal trends, wheezing, Italy, Abstract The prevalence of asthma increased worldwide until the 1990s, but since then there has been no clear temporal pattern. The present study aimed to assess time trends in the prevalence of current asthma, asthma-like symptoms and allergic rhinitis in Italian adults from 1990 to 2010. The same screening questionnaire was administered by mail or phone to random samples of the general population (age 20-44 yrs) in Italy, in the frame of three multicentre studies: the European Community Respiratory Health Survey (ECRHS) (1991-1993, n=6,031), the Italian Study on Asthma in Young Adults (ISAYA) (1998-2000, n=18,873), and the Gene Environment Interactions in Respiratory Diseases (GEIRD) study (2007-2010, n=10,494). Time trends in prevalence were estimated using Poisson regression models in the centres that repeated the survey at different points in time. From 1991 to 2010, the median prevalence of current asthma, wheezing and allergic rhinitis increased from 4.1% to 6.6%, from 10.1% to 13.9% and from 16.8% to 25.8%, respectively. The prevalence of current asthma was stable during the 1990s and increased (relative risk 1.38, 95% CI 1.19-1.59) from 1998-2000 to 2007-2010, mainly in subjects who did not report allergic rhinitis. The prevalence of allergic rhinitis has increased continuously since 1991. The asthma epidemic is not over in Italy. During the past 20 yrs, asthma prevalence has increased by 38%, in parallel with a similar increase in asthma-like symptoms and allergic rhinitis, mainly in subjects who did not report allergic rhinitis. The prevalence of allergic rhinitis has increased continuously since 1991. The asthma epidemic is not over in Italy. During the past 20 yrs, symbols, asthma prevalence has increased by 38%, Female, epidemiology, Human, Pulmonary and Respiratory Medicine, Adult, 494). Time trends in prevalence were estimated using Poisson regression models in the centres that repeated the survey at different points in time. From 1991 to 2010, in parallel with a similar increase in asthma-like symptoms and allergic rhinitis, medicine.medical_specialty, Rhinitis, Allergic, Perennial, Population, prevalence, Settore MED/10 - Malattie Dell'Apparato Respiratorio, 031), Settore MED/01 - Statistica Medica, symbols.namesake, Young Adult, Allergic rhiniti, Humans, Respiratory sounds, Poisson regression, education, Respiratory Sounds, Cross-Sectional Studie, allergic rhinitis, business.industry, wheezing, wheezing and allergic rhinitis increased from 4.1% to 6.6%, Rhinitis, Allergic, Seasonal, asthma, in the frame of three multicentre studies: the European Community Respiratory Health Survey (ECRHS) (1991-1993, medicine.disease, 873), Cross-Sectional Studies, n=10, Relative risk, Temporal trend, Respiratory Sound, n=6, n=18, business
Abstract

The prevalence of asthma increased worldwide until the 1990s, but since then there has been no clear temporal pattern. The present study aimed to assess time trends in the prevalence of current asthma, asthma-like symptoms and allergic rhinitis in Italian adults from 1990 to 2010. The same screening questionnaire was administered by mail or phone to random samples of the general population (age 20-44 yrs) in Italy, in the frame of three multicentre studies: the European Community Respiratory Health Survey (ECRHS) (1991-1993; n=6,031); the Italian Study on Asthma in Young Adults (ISAYA) (1998-2000; n=18,873); and the Gene Environment Interactions in Respiratory Diseases (GEIRD) study (2007-2010; n=10,494). Time trends in prevalence were estimated using Poisson regression models in the centres that repeated the survey at different points in time. From 1991 to 2010, the median prevalence of current asthma, wheezing and allergic rhinitis increased from 4.1% to 6.6%, from 10.1% to 13.9% and from 16.8% to 25.8%, respectively. The prevalence of current asthma was stable during the 1990s and increased (relative risk 1.38, 95% CI 1.19-1.59) from 1998-2000 to 2007-2010, mainly in subjects who did not report allergic rhinitis. The prevalence of allergic rhinitis has increased continuously since 1991. The asthma epidemic is not over in Italy. During the past 20 yrs, asthma prevalence has increased by 38%, in parallel with a similar increase in asthma-like symptoms and allergic rhinitis. Copyright©ERS 2012.

Published
2012

14. Lung cancer: can staging improvement ensure a better survival?

Author

Gm, Stella, Cazzoletti L, and Alessandro Zanforlin

Subjects
Survival, Lung Cancer
Abstract

Lung cancer is among the most common cancers in the world. Despite advances in defining the molecular mechanisms involved in lung oncogenesis and the remarkable efforts made to improve screening programs for secondary cancer prevention, patients' prognosis remains poor. Moreover, wide international inequalities remain apparent, even among developed countries. Here we analyze and discuss the findings of the extensive work by Walters S et al., recently published in "Thorax", which aimed to clarify whether differences in stage at diagnosis might explain these divergences. A better understanding of why survival differences between different states still exist will facilitate policy design to increase lung cancer overall survival itself and to bring it up to the highest international standards. It is the first international population-based study of lung cancer survival by stage at diagnosis and includes nearly 60,000 patients. By using a well detailed and appropriate statistical approach, authors conclude that improvement in outcomes is primarily related to a proper initial disease staging and that socioeconomic international and interregional inequalities might play a relevant role in this scenario. Our review takes in consideration both the methodological and scientific issues of the paper, focusing on the potential consequences in lung cancer management and on the need, in the post genomic era, of a molecular-based epidemiologic approach.

Published
2013

15. The impact of climate and traffic-related NO2 on the prevalence of asthma and allergic rhinitis in Italy

Author

de Marco, R, Poli, A, Ferrari, M, Accordini, S, Giammanco, G, Bugiani, M, Villani, S, Ponzio, M, Bono, R, Carrozzi, L, Cavallini, R, Cazzoletti, L, Dallari, R, Ginesu, F, Lauriola, P, Mandrioli, P, Perfetti, L, Pignato, S, Pirina, P, STRUZZO, PIERLUIGI, de Marco, R, Poli, A, Ferrari, M, Accordini, S, Giammanco, G, Bugiani, M, Villani, S, Ponzio, M, Bono, R, Carrozzi, L, Cavallini, R, Cazzoletti, L, Dallari, R, Ginesu, F, Lauriola, P, Mandrioli, P, Perfetti, L, Pignato, S, Pirina, P, and Struzzo, Pierluigi

Subjects
Adult, Rhinitis, Allergic, Perennial, Ultraviolet Rays, Climate, Nitrogen Dioxide, Asthma, Cross-Sectional Studies, Humans, Italy, Multivariate Analysis, Prevalence, Temperature, Vehicle Emissions, traffic-related pollution, allergic rhinitis, asthma, climate, outdoor NO2 pollution, traffic-related pollution, Allergic, Multivariate Analysi, climate, Rhinitis, Cross-Sectional Studie, allergic rhinitis, asthma, Perennial, Ultraviolet Ray, outdoor NO2 pollution, Human
Abstract

Environmental factors are likely to be involved in explaining the wide geographical variation in asthma and atopic diseases that has been documented in many recent epidemiological studies.

Published
2002

16. Trends in the prevalence of asthma and allergic rhinitis in Italy between 1991 and 2010

Author

de Marco, R, Cappa, V, Accordini, S, Rava, M, Antonicelli, L, Bortolami, O, Braggion, M, Bugiani, M, Casali, L, Cazzoletti, L, Cerveri, I, Fois, Ag, Girardi, P, Locatelli, F, Marcon, A, Marinoni, A, Panico, Mg, Pirina, P, Villani, S, Zanolin, Me, Verlato, G, Montoli, E, Vesentini, R, Ferrari, M, Donatelli, L, Posenato, C, Cascio, V, Perbellini, L, Olivieri, M, D'Amato, J, Donatini, E, Martinelli, M, Pignatti, Pf, Bombieri, C, Bettin, Md, Trabetti, E, Poli, A, Nicolis, M, Sembeni, S, Bonifazi, F, Attena, F, Galdo, V, Bellia, V, Battaglia, S, Corsico, Ag, Albicini, F, Grosso, A, Ferretti, V, Miniucchi, A, Briziarelli, L, Marcarelli, M, Becciu, F, Deledda, A, Spada, V, Carosso, A, Piccioni, P, Castiglioni, G, Bono, R, Tassinari, R, Romanazzi, V, Rolla, G, Heffler, ENRICO MARCO, and Migliore, E.

Published
2012

17. Gene Environment Interactions in Respiratory Diseases. Protocol, Standard Operative Procedures and Questionnaires

Author

de Marco, R, Verlato, G, Zanolin, Me, Accordini, S, Bortolami, O, Braggion, M, Cappa, V, Cazzoletti, L, Girardi, P, Locatelli, F, and Others

Subjects
Genes,Chronic obstructive pulmonary disease,Asthma, Rhinitis,Case-control,Environment,Inflammatory biomarkers,Diet, Genes, Chronic obstructive pulmonary disease, Inflammatory biomarkers, Case-control, Environment, Asthma, Rhinitis, Diet, Settore MED/01 - Statistica Medica
Published
2010

18. Gene Environment Interactions in Respiratory Diseases – Protocol, Standard Operative Procedures and Questionnaires

Author

The GEIRD Study Group: de Marco, R, Verlato, G, Zanolin, Me, Accordini, S, Bortolami, O, Braggion, M, Cappa, V, Cazzoletti, L, Girardi, P, Locatelli, F, Marcon, A, Nicolis, D, Rava, M, Vesentini, R, Ferrari, M, Donatelli, L, Posenato, C, Lo Cascio, V, Perbellini, L, Olivieri, M, D’Amato, J, Donatini, E, Martinelli, M, Pignatti, Pf, Bombieri, C, Bettin, Md, Trabetti, E, Poli, A, Nicolis, M, Sembeni, S, Antonicelli, L, Bonifazi, F, Attena, F, Galdo, V, Bellia, V, Battaglia, S, Cerveri, I, Corsico, Ag, Albicini, F, Grosso, A, Marinoni, A, Casali, L, Miniuc chi, A, Briziarelli, L, Marcarelli, M, Panico, Mg, Pirina, P, Fois, Ag, Becciu, F, Deledda, A, Spada, V, Bugiani, M, Carosso, A, Piccioni, P, Castiglioni, G, Bono, R, Tassinari, R, Romanazzi, V, Rolla, G, Heffler, ENRICO MARCO, and Migliore, E.

Published
2010

19. Adult eczema in Italy: prevalence and associations with environmental factors

Author

Pesce, G., primary, Marcon, A., additional, Carosso, A., additional, Antonicelli, L., additional, Cazzoletti, L., additional, Ferrari, M., additional, Fois, A.G., additional, Marchetti, P., additional, Olivieri, M., additional, Pirina, P., additional, Pocetta, G., additional, Tassinari, R., additional, Verlato, G., additional, Villani, S., additional, and de Marco, R., additional

Published
2014
Full Text
View/download PDF

23. Allergic rhinitis and asthma comorbidity in a survey of young adults in Italy

Author

Bugiani, M., Carosso, A., Migliore, E., Piccioni, P., Corsico, A., Olivieri, M., Ferrari, M., Pirina, P., Marinoni, R. de Marco on behalf of ISAYA: Principal researchers: A., Carolei, A., Montomoli, C., Villani, S., Comelli, M., Ponzio, M., Grassi, M., Rezzani, C., Casali, L., Cerveri, I., Zoia, M. C., Colato, S., Moscato, G., Perfetti, L., Alesina, R., Basso, O., Berrayah, L., Brusotti, R., Fanfulla, F., Moi, P., Frati, C., Karytinos, P., Arossa, W., Caria, E., Castiglioni, G., Romano, Canzio, Fabbro, D., Ciccone, G., Magnani, C., Dalmasso, P., Bono, Roberto, Gigli, G., Giraudo, A., Brussino, M. C., Bucca, Caterina, Rolla, Giovanni, Aime, M., Cerutti, A., Chiampo, F., Gallo, W., Sulotto, F., de Marco, R., Verlato, G., Accordini, S., Zanolin, M. E., Locatelli, F., Cazzoletti, L., Pattaro, C., Sartori, S., Poli, A., Dorigo, N., Cantarelli, S., Ciresola, D., Lo Cascio, V., Biasin, C., Campello, C., Rossi, F., Cannistra`, A., Cenci, B., Destefani, E., Girotto, M., Lampronti, G., Martini, C., Tardivo, S., Villani, A., Lauriola, P., Danielli, G., Sesti, D., Ghigli, E., P. Natale, M. Grosa, Tacconi, A., Frontero, P., and Salomoni, A.

Published
2005

24. The role of climate on the geographic variability of asthma, allergic rhinitis and respiratory symptoms: results from the Italian study of asthma in young adults

Author

Zanolin, M. E., Pattaro, C., Corsico, A., Bugiani, M., Carrozzi, L., Casali, L., Dallari, R., Ferrari, M., Marinoni, A., Migliore, E., Olivieri, M., Pirina, P., Verlato, G., Villani, S., de Marco, R., Buriani, O., Cavallini, R., Saletti, C., Cellini, M., Faustini, M., de Togni, A., Carolei, A., Montomoli, C., Comelli, M., Ponzio, M., Grassi, M., Rezzani, C., Cerveri, I., Zoia, M. C., Colato, S., Moscato, G., Perfetti, L., Viegi, G., Pistelli, F., di Pede, F., Paggiaro, P. L., Santolicandro, A., Giovannetti, P., Ginesu, F., Ostera, S., Pinna, G. P., Farre, A., Imparato, S., Turrini, E., Foglia, M., Giammanco, G., Pignato, S., Rotondo, A., Cuspilici, A., Piccioni, P., Carosso, A., Arossa, W., Caria, E., Castiglioni, G., Romano, C., Fabbro, D., Ciccone, G., Magnani, C., Dalmasso, P., Bono, R., Gigli, G., Giraudo, A., Brussino, M. C., Bucca, C., Rolla, G., Struzzo, P., Orefice, U., Schneider, M., Chittaro, F., Peresson, D., Accordini, S., Locatelli, F., Cazzoletti, L., Sartori, S., Poli, A., Dorigo, N., Cantarelli, S., Ciresola, D., Lo Cascio, V., Biasin, C., Lauriola, P., Danielli, G., Sesti, D., Ghigli, E., Natale, P., Grosa, M., Tacconi, A., Frontero, P., and Salomoni, A.

Subjects
Adult, medicine.medical_specialty, Allergy, Rhinitis, Allergic, Perennial, Climate, Immunology, Geographic pattern, Allergic, Epidemiology, medicine, Prevalence, Immunology and Allergy, Humans, Asthma epidemiology, Asthma prevalence allergy, Latitude, Asthma, Chronic Disease, Cough, Geography, Regression Analysis, Rhinitis, Allergic, Seasonal, Rhinitis, Seasonal, business.industry, Phlegm, Respiratory disease, Odds ratio, medicine.disease, Perennial, respiratory tract diseases, Chronic cough, Etiology, medicine.symptom, business, Demography
Abstract

Background: Variations in the prevalence of respiratory symptoms according to geo-climatic factors could provide important clues to the knowledge of the aetiology of asthma. Methods: Geo-climatic variations in the prevalence of current asthma, allergic rhinitis and chronic cough, and phlegm were assessed on a random sample of 18 873 subjects (response rate = 72.7%) from different climatic regions of Italy. An ecological analysis, supported by robust statistical methods, was employed to investigate potential trends. Results: The prevalence of all symptoms was significantly heterogeneous throughout the peninsula. Only asthma-like symptoms showed a north–south trend: the prevalence increased at a decreasing latitude [odds ratio (OR) varies from 0.92 to 0.96, P

Published
2004

25. The role of climate on the geographic variability of asthma, allergicrhinitis and respiratory symptoms: results from the Italian study of asthma in young adults

Author

Zanolin, M. E., Pattaro, C., Corsico, . A., Bugiani, M., Carrozzi, L., Casali, . L., Dallari, R., Ferrari, M., Marinoni, . A., Migliore, E., Olivieri, M., P. P. i. r. i. n. a., . G. Verlato, Villani, . S., Demarco, R., Buriani, . O., Cavallini, R., Saletti, C., Cellini, M., Faustini, M., de Togni, A., Marinoni, A., Carolei, A., Montomoli, C., Villani, S., Comelli, M., Ponzio, . M., Grassi, M., Rezzani, C., Casali, L., Cerveri, I., Zoia, M. C., Corsico, A., Colato, S., Moscato, G., Perfetti, . L., Viegi, G., Pistelli, F., Di Pede, F., Paggiaro, P. L., Santolicandro, A., Giovannetti, P., Ginesu, F., Pirina, P., Ostera, S., Pinna, G. P., Farre, A., Imparato, S., Turrini, E., Foglia, . M., Giammanco, G., Pignato, S., Rotondo, . A., Cuspilici, A., Piccioni, P., Carosso, . A., Arossa, W., Caria, E., Castiglioni, G., Romano, Canzio, Fabbro, D., Ciccone, G., Magnani, . C., Dalmasso, P., Bono, Roberto, Gigli, G., Giraudo, A., Brussino, Luisa, Bucca, Caterina, Rolla, Giovanni, Struzzo, P., Orefice, . U., Schneider, M., Chittaro, F., Peresson, D., de Marco, R., Verlato, G., Accordini, S., Locatelli, F., Cazzoletti, L., Sartori, S., Poli, . A., Dorigo, N., Cantarelli, S., Ciresola, D., Lo Cascio, V., Biasin, C., Lauriola, P., Danielli, G., Sesti, D., Ghigli, E., P. Natale, M. Grosa, Tacconi, A., Frontero, P., and Salomoni, A.

Subjects
climate, asthma, allergic rhinitis, respiratory symptoms
Published
2004

26. Chronic cough and phlegm in young adults

Author

Cerveri, I., Accordini, S., Corsico, A., Zoia, M. C., Carrozzi, L., Cazzoletti, L., Beccaria, M., Marinoni, A., Viegi, G., de Marco, R., Ginesu, F., Pirina, P., Ostera, S., Pinna, G. P., Farre, A., Imparato, S., Dallari, R., Turrini, E., Foglia, M., Giammanco, G., Pignato, S., Rotondo, A., Cuspilici, A., Bugiani, M., Piccioni, P., Carosso, A., Arossa, W., Caria, E., Castiglioni, G., Migliore, E., Romano, C., Fabbro, D., Ciccone, G., Magnani, C., Dalmasso, P., Bono, R., Gigli, G., Giraudo, A., Brussino, M. C., Bucca, C., Rolla, G., Struzzo, P., Orefice, U., Schneider, M., Chittaro, F., Peresson, D., Verlato, G., Zanolin, M. E., Locatelli, F., Battisti, L., Pattaro, C., Poli, A., Dorigo, N., Cantarelli, S., Ciresola, D., Lo Cascio, V., Olivieri, M., Ferrari, M., Biasin, C., Lauriola, P., Danielli, G., Sesti, D., Ghigli, E., Natale, P., Grosa, M., Tacconi, A., Frontero, P., and Salomoni, A.

Subjects
Pulmonary and Respiratory Medicine, Adult, Male, Pediatrics, medicine.medical_specialty, Chronic Obstructive, Cross-sectional study, Health surveys, Population, chronic obstructive pulmonary disease, cross-sectional studies, health surveys, risk factors, smoking, Pulmonary Disease, Pulmonary Disease, Chronic Obstructive, Sex Factors, Epidemiology, medicine, Prevalence, Chronic obstructive pulmonary disease, Cross-sectional studies, Risk factors, Smoking, Asthma, Chronic Disease, Cough, Cross-Sectional Studies, Female, Humans, Italy, Socioeconomic Factors, Sputum, Young adult, education, education.field_of_study, business.industry, Phlegm, medicine.disease, Obstructive lung disease, respiratory tract diseases, Chronic cough, medicine.symptom, business
Abstract

The Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines underline that the presence of chronic cough and sputum production before airflow obstruction offers a unique opportunity to identify subjects at risk of chronic obstructive pulmonary disease for an early intervention. Current epidemiological data on these subjects are scant. Between 1998-2000, the authors evaluated the prevalence and characteristics of these symptoms by a multicentre cross-sectional survey of Italian people aged between 20-44 yrs from the general population (Italian Study on Asthma in Young Adults (ISAYA)). Besides the questions on asthma, more than 18,000 subjects answered the question: "Have you had cough and phlegm on most days for as much as 3 months per year and for at least two successive years?" The adjusted prevalence of subjects with chronic cough and phlegm was 11.9%, being 11.8% in males and 12.0% in females. From these subjects approximately 20% reported coexisting asthma and approximately 30%, predominately females, were nonsmokers. The survey showed that sex (female), smoking and low socioeconomic status were significantly and independently associated with chronic cough and phlegm, current smoking playing the major role. The prevalence of subjects with chronic cough and phlegm is startlingly high among young adults. Further follow-up studies are needed to establish how many of them will go on to develop chronic obstructive pulmonary disease.

Published
2003

27. Is the prevalence of adult asthma and allergic rhinitis still increasing? Results of an Italian study

Author

Verlato, G, Corsico, A, Villani, S, Cerveri, I, Migliore, E, Accordini, S, Carolei, A, Piccioni, P, Bugiani, M, Lo Cascio, V, Marinoni, A, Poli, A, Ecrhs, de Marco R., Marinoni, ISAYA group Principal researchers: A., Carolei, A., Montomoli, C., Villani, S., Comelli, M., Ponzio, M., Grassi, M., Rezzani, C., Casali, L., Cerveri, I., Zoia, M. C., Corsico, A., Colato, S., Moscato, G., Perfetti, L., Alesina, R., Basso, O., Berrayah, L., Brusotti, R., Fanfulla, F., Moi, P., Frati, C., Karytinos, P., Bugiani, M., Piccioni, P., Carosso, A., Arossa, W., Caria, E., Castiglioni, G., Migliore, E., Romano, C., Fabbro, D., Ciccone, G., Magnani, C., Dalmasso, Paola, Bono, Roberto, Gigli, G., Giraudo, A., Brussino, Luisa, Bucca, Caterina, Rolla, Giovanni, Aime, M., Cerutti, A., Chiampo, F., Gallo, W., Sulotto, F., de Marco, R., Verlato, G., Accordini, S., Zanolin, M. E., Locatelli, F., Cazzoletti, L., Pattaro, C., Sartori, S., Poli, A., Dorigo, N., Cantarelli, S., Ciresola, D., Lo Cascio, V., Olivieri, M., Ferrari, M., Biasin, C., Campello, C., Rossi, F., Cannistrà, A., Cenci, B., Destefani, E., Girotto, M., Lampronti, G., Martini, C., Tardivo, S., Villani, A., Lauriola, P., Danielli, G., Sesti, D., Ghigli, E., Natale, P., Grosa, M., Tacconi, A., Frontero, P., and Salomoni, A.

Subjects
Adult, Male, Pediatrics, medicine.medical_specialty, Allergy, Rhinitis, Allergic, Perennial, temporal trend, Immunology, Logistic regression, asthma, allergic rhinitis, temporal trend, epidemiology, Epidemiology, Prevalence, Immunology and Allergy, Medicine, Humans, Non-response bias, Young adult, Asthma, Response rate (survey), allergic rhinitis, business.industry, Rhinitis, Allergic, Seasonal, Odds ratio, asthma, medicine.disease, Italy, Female, epidemiology, business
Abstract

The prevalence of asthma and allergic rhinitis has increased worldwide during the 1970s and 1980s.This study was aimed at evaluating whether the increasing trend in prevalence persisted during the 1990s in the young adult Italian population.In 1998 to 2000 a screening questionnaire was sent by mail to a general population sample aged 20 to 44 years; nonresponders were contacted again first by mail and then by phone, achieving a final response rate of 78.1% (6876 of 8800). Prevalence estimates, adjusted to correct for nonresponse bias, were compared with those recorded in Italy in 1991 to 1993 during the European Community Respiratory Health Survey, when response rate had been slightly higher (87.6%). Temporal variations in symptom prevalence were analyzed by a logistic regression model, controlling for sex, age, site of residence (urban vs suburban areas), season of response, response rate, and type of contact (mail vs phone).The prevalence of asthma attacks did not vary significantly from 1991 to 1993 (3.6%) to 1998 to 2000 (3.2%) (P =.188). The prevalence of asthma-like symptoms (wheezing, chest tightness, shortness of breath) tended to decrease in the age classes of 32.5 to 45 years, while increasing in the youngest age class (20 to 26 years). A clear-cut increase from 15.4% to 18.3% was observed for the prevalence of allergic rhinitis (P.001), whereas the proportion of people under antiasthmatic treatment increased in suburban areas but not in urban areas (interaction time-site of residence, P.001).Asthma prevalence has not increased during the last decade in Italy. The persistence of an increasing trend in allergic rhinitis prevalence deserves attention.

Published
2003

28. Incidence and remission of asthma: a retrospective study on the natural history of asthma in Italy

Author

De Marco, R., Locatelli, F., Cerveri, I., Bugiani, M., Marinoni, A., Giammanco, G., Accordini, S., Verlato, G., Zanolin, E., Buriani, O., Carrozzi, L., Dallari, R., Ginesu, F., Poli, A., Struzzo, P., Cavallini, R., Saletti, C., Cellini, M., Faustini, M., De Togni, A., Carolei, A., Montomoli, C., Villani, S., Comelli, M., Ponzio, M., Grassi, M., Rezzani, C., Casali, L., Zoia, M. C., Corsico, A., Colato, S., Moscato, G., Perfetti, L., Viegi, G., Pistelli, F., Di Pede, F., Paggiaro, P. L., Santolicandro, A., Giovannetti, P., Pirina, P., Ostera, S., Pinna, G. P., Farre, A., Imparato, S., Turrini, E., Foglia, M., Pignato, S., Rotondo, A., Cuspilici, A., Piccioni, P., Carosso, A., Arossa, W., Caria, E., Castiglioni, G., Migliore, E., Romano, C., Fabbro, D., Ciccone, G., Magnani, C., Dalmasso, P., Bono, R., Gigli, G., Giraudo, A., Brussino, M. C., Bucca, C., Rolla, G., Orefice, U., Schneider, M., Chittaro, F., Peresson, D., Zanolin, M. E., Cazzoletti, L., Battisti, L., Pattaro, C., Dorigo, N., Cantarelli, S., Ciresola, D., Lo Cascio, V., Olivieri, M., Ferrari, M., Biasin, C., Lauriola, P., Danielli, G., Sesti, D., Ghigli, E., Natale, P., Grosa, M., Tacconi, A., Frontero, P., and Salomoni, A.

Subjects
Adult, Male, Pediatrics, medicine.medical_specialty, Adolescent, National Health Programs, Remission, Cross-sectional study, Immunology, Population, Remission, Spontaneous, Rate ratio, Asthma remission, Asthma incidence, Persistence of asthma, Asthma, Child, Child, Preschool, Cross-Sectional Studies, Female, Humans, Incidence, Infant, Infant, Newborn, Italy, Retrospective Studies, medicine, Immunology and Allergy, Young adult, Preschool, education, education.field_of_study, business.industry, Spontaneous, Incidence (epidemiology), Retrospective cohort study, Newborn, medicine.disease, Natural history, business
Abstract

The knowledge of the natural history of asthma from birth to adulthood could provide important clues for its cause and for the understanding of epidemiologic findings.This study is aimed at assessing the incidence and remission of asthma from birth to the age of 44 years by using data from 18,873 subjects involved in a large, nationally representative, cross-sectional study carried out in Italy from 1998 through 2000.The onset of asthma was defined as the age at the first attack, and remission was considered present when a subject was neither under treatment nor had experienced an asthma attack in the last 24 months. Person-years and survival techniques were used for the analysis.The average annual incidence rate for the 1953 to 2000 period was 2.56/1000 persons per year. Incidence peaked in boys less than 10 years of age (4.38/1000 persons per year) and in women 30 years of age or older (3.1/1000 persons per year) and showed a generational increase (incident rate ratio = 2.63 and 95% CI = 2.20-3.12 for 1974-1979 vs 1953-1958 birth cohort). The overall remission rate was 45.8% (41.6% in women and 49.5% in men, P.001). Asthmatic patients in remission had an earlier age at onset (7.8 vs 15.9 years, P.001) and a shorter duration of the disease (5.6 vs 16.1 years, P.001) than patients with current asthma. The probability of remission was strongly (P.001) and inversely related to the age at onset (62.8% and 15.0% in the10- andor =20-years age-at-onset groups, respectively).With respect to its natural history, asthma presents 2 different forms: early-onset asthma, which occurs early in childhood, affects mainly boys, and has a good prognosis, and late-onset asthma, which generally occurs during or after puberty, mainly affects women, and has a poor prognosis. The minority of patients with early-onset asthma who do not remit represents more than 35% of patients with current asthma in the general young adult population.

Published
2002

29. The impact of climate and traffic-related NO 2 on the prevalence of asthma and allergic rhinitis in Italy

Author

De Marco, R., Poli, A., Ferrari, M., Accordini, S., Giammanco, G., Bugiani, M., Villani, S., Ponzio, M., Bono, R., Carrozzi, L., Cavallini, R., Cazzoletti, L., Dallari, R., Ginesu, F., Lauriola, P., Mandrioli, P., Perfetti, L., Pignato, S., Pirina, P., and Struzzo, P.

Subjects
Adult, Ultraviolet Rays, Climate, Nitrogen Dioxide, Temperature, Allergic rhinitis, Asthma, Outdoor NO2 pollution, Traffic-related pollution, Cross-Sectional Studies, Humans, Italy, Multivariate Analysis, Prevalence, Rhinitis, Allergic, Perennial, Vehicle Emissions, Perennial, Allergic, Rhinitis
Published
2002

30. Incidence and remission of asthma: A retrospective study on the natural history of asthma in Italy

Author

de Marco, R, Locatelli, F, Cerveri, I, Bugiani, M, Marinoni, A, Giammanco, G, Buriani, for the Italian Study on Asthma in Young Adults study group Principal researchers: O., Cavallini, R., Saletti, C., Cellini, M., Faustini, M., de Togni, A., Marinoni, A., Carolei, A., Montomoli, C., Villani, S., Comelli, M., Ponzio, M., Grassi, M., Rezzani, C., Casali, L., Cerveri, I., Zoia, M. C., Corsico, A., Colato, S., Moscato, G., Perfetti, L., Carrozzi, L., Viegi, G., Pistelli, F., Di Pede, F., Paggiaro, P. L., Santolicandro, A., Giovannetti, P., Ginesu, F., Pirina, P., Ostera, S., Pinna, G. P., Farre, A., Imparato, S., Dallari, R., Turrini, E., Foglia, M., Giammanco, G., Pignato, S., Rotondo, A., Cuspilici, A., Bugiani, M., Piccioni, P., Carosso, A., Arossa, W., Caria, E., Castiglioni, G., Migliore, E., Romano, Canzio, Fabbro, D., Ciccone, G., Magnani, C., Dalmasso, Paola, Bono, Roberto, Gigli, G., Giraudo, A., Brussino, Luisa, Bucca, Caterina, Rolla, Giovanni, Struzzo, P., Orefice, U., Schneider, M., Chittaro, F., Peresson, D., de Marco, R., Verlato, G., Accordini, S., Zanolin, M. E., Locatelli, F., Cazzoletti, L., Battisti, L., Pattaro, C., Poli, A., Dorigo, N., Cantarelli, S., Ciresola, D., Lo Cascio, V., Olivieri, M., Ferrari, M., Biasin, C., Lauriola, P., Danielli, G., Sesti, D., Ghigli, E., P. Natale, M. Grosa, Tacconi, A., Frontero, P., and Salomoni, A.

Published
2002

31. ADRB2 Gly16Arg polymorphism, asthma control and lung function decline

Author

Rebordosa, C, Kogevinas, M, Guerra, S, Castro-Giner, F, Jarvis, D, Cazzoletti, L, Pin, I, Siroux, V, Wjst, M, Antò, J M, de Marco, R, Estivill, X, Corsico, A G, Nielsen, R, Janson, Christer, Rebordosa, C, Kogevinas, M, Guerra, S, Castro-Giner, F, Jarvis, D, Cazzoletti, L, Pin, I, Siroux, V, Wjst, M, Antò, J M, de Marco, R, Estivill, X, Corsico, A G, Nielsen, R, and Janson, Christer

Abstract

Arg/Arg homozygotes for the Gly16Arg polymorphism in the β(2)-adrenoreceptor gene (ADRB2) have a reduced response to short-acting β(2)-agonists but no effect has been associated with long-acting β(2)-agonists (LABAs). We selected 604 subjects with current asthma from the European Community Respiratory Health Study to evaluate whether asthma control and lung function decline were associated with Gly16Arg polymorphism, and to test whether LABA or inhaled corticosteroid (ICS) use modified these effects. There was an increased risk of noncontrolled asthma (OR 1.33, 95% CI 1.01-1.75; p=0.046) for each Arg allele. Among nonusers of ICS, the odds ratio of noncontrolled asthma among Arg/Arg versus Gly/Gly subjects was 2.73 (95% CI 1.28-5.82; p=0.009). No increased risk of noncontrolled asthma associated with the Arg allele was observed among ICS and/or LABA users. For each Arg allele, a mean±se decrease in decline in forced expiratory volume in 1 s of 7.7±2.5 mL·yr(-1) was found (p-value for trend 0.003), irrespective of ICS or LABA use. Arg/Arg subjects had an increased risk of bronchial hyperresponsiveness (BHR) versus Gly/Gly subjects, with an odds ratio of 2.51 (95% CI 1.12-5.63; p=0.025) if they did not use ICS. The Arg allele was associated with poorer asthma control, a steeper lung function decline and BHR. Absence of genotypic effects on asthma control among ICS users may be due to reversed β(2)-adrenoreceptor desensitisation.

Published
2011
Full Text
View/download PDF

33. The socio-economic burden of asthma is substantial in Europe

Author

Accordini, S, Corsico, A, Cerveri, I, Gislason, D, Gulsvik, A, Janson, C, Jarvis, D, Marcon, A, Pin, I, Vermeire, P, Almar, E, Bugiani, M, Cazzoletti, L, Duran-Tauleria, E, Jõgi, R, Marinoni, A, Martínez-Moratalla, J, Leynaert, B, de Marco, R, Accordini, S, Corsico, A, Cerveri, I, Gislason, D, Gulsvik, A, Janson, C, Jarvis, D, Marcon, A, Pin, I, Vermeire, P, Almar, E, Bugiani, M, Cazzoletti, L, Duran-Tauleria, E, Jõgi, R, Marinoni, A, Martínez-Moratalla, J, Leynaert, B, and de Marco, R

Abstract

BACKGROUND: Few data are available on the asthma burden in the general population. We evaluated the level and the factors associated with the asthma burden in Europe. METHODS: In 1999-2002, 1152 adult asthmatics were identified in the European Community Respiratory Health Survey (ECRHS)-II and the socio-economic burden (reduced activity days and hospital services utilization in the past 12 months) was assessed. RESULTS: The asthmatics with a light burden (only a few reduced activity days) were 13.2% (95% CI: 11.4-15.3%), whereas those with a heavy burden (many reduced activity days and/or hospital services utilization) were 14.0% (95% CI: 12.1-16.1%). The burden was strongly associated with disease severity and a lower quality of life. Obese asthmatics had a significantly increased risk of a light [relative risk ratio (RRR) = 2.17; 95% CI: 1.18-4.00] or a heavy burden (RRR = 2.77; 95% CI: 1.52-5.05) compared with normal/underweight subjects. The asthmatics with frequent respiratory symptoms showed a threefold (RRR = 2.74; 95% CI: 1.63-4.61) and sixfold (RRR = 5.76; 95% CI: 3.25-10.20) increased risk of a light or a heavy burden compared with asymptomatic asthmatics, respectively. Moreover, the lower the forced expiratory volume in 1 s % predicted, the higher the risk of a heavy burden. The coexistence with chronic cough/phlegm only increased the risk of a heavy burden (RRR = 1.88; 95% CI: 1.16-3.06). An interaction was found between gender and IgE sensitization, with nonatopic asthmatic females showing the highest risk of a heavy burden (21.6%; 95% CI: 16.9-27.1%). CONCLUSIONS: The asthma burden is substantial in Europe. A heavy burden is more common in asthmatics with obesity, frequent respiratory symptoms, low lung function, chronic cough/phlegm and in nonatopic females.

Published
2008
Full Text
View/download PDF

34. Occupational exposures and uncontrolled adult-onset asthma in the European Community Respiratory Health Survey II

Author

Le Moual, N., primary, Carsin, A.-E., additional, Siroux, V., additional, Radon, K., additional, Norback, D., additional, Toren, K., additional, Olivieri, M., additional, Urrutia, I., additional, Cazzoletti, L., additional, Jacquemin, B., additional, Benke, G., additional, Kromhout, H., additional, Mirabelli, M. C., additional, Mehta, A. J., additional, Schlunssen, V., additional, Sigsgaard, T., additional, Blanc, P. D., additional, Kogevinas, M., additional, Anto, J. M., additional, and Zock, J.-P., additional

Published
2013
Full Text
View/download PDF

35. Changes in the use of anti-asthmatic medication in an international cohort.

Author

Janson, Christer, de Marco, R, Accordini, S, Almar, E, Bugiani, M, Carolei, A, Cazzoletti, L, Cerveri, I, Corsico, A, Duran-Tauleria, E, Gislason, D, Gulsvik, Amund, Jögi, Rain, Marinoni, A, Martínez-Moratalla, J, Pin, I, Vermeire, P, Jarvis, D, Janson, Christer, de Marco, R, Accordini, S, Almar, E, Bugiani, M, Carolei, A, Cazzoletti, L, Cerveri, I, Corsico, A, Duran-Tauleria, E, Gislason, D, Gulsvik, Amund, Jögi, Rain, Marinoni, A, Martínez-Moratalla, J, Pin, I, Vermeire, P, and Jarvis, D

Published
2005

36. Trends in the prevalence of asthma and allergic rhinitis in Italy between 1991 and 2010

Author

de Marco, R., primary, Cappa, V., additional, Accordini, S., additional, Rava, M., additional, Antonicelli, L., additional, Bortolami, O., additional, Braggion, M., additional, Bugiani, M., additional, Casali, L., additional, Cazzoletti, L., additional, Cerveri, I., additional, Fois, A.G., additional, Girardi, P., additional, Locatelli, F., additional, Marcon, A., additional, Marinoni, A., additional, Panico, M.G., additional, Pirina, P., additional, Villani, S., additional, Zanolin, M.E., additional, and Verlato, G., additional

Published
2011
Full Text
View/download PDF

37. ADRB2 Gly16Arg polymorphism, asthma control and lung function decline

Author

Rebordosa, C., primary, Kogevinas, M., additional, Guerra, S., additional, Castro-Giner, F., additional, Jarvis, D., additional, Cazzoletti, L., additional, Pin, I., additional, Siroux, V., additional, Wjst, M., additional, Anto, J. M., additional, de Marco, R., additional, Estivill, X., additional, Corsico, A. G., additional, Nielsen, R., additional, and Janson, C., additional

Published
2011
Full Text
View/download PDF

38. The control of asthma in Italy. The results og a multicentre Italian Study

Author

De Marco, R, Bugiani, M, Cazzoletti, L, Carosso, A, Accordini, S, Buriani, O, Carozzi, L, Dallari, R, Giammanco, G, Ginesu, F, Marioni, A, Lo Cascio, Poli, A, Struzzo, P, Janson, C, De Marco, R, Bugiani, M, Cazzoletti, L, Carosso, A, Accordini, S, Buriani, O, Carozzi, L, Dallari, R, Giammanco, G, Ginesu, F, Marioni, A, Lo Cascio, Poli, A, Struzzo, P, and Janson, C

Published
2003

42. Chronic cough and phlegm in young adults

Author

Cerveri, I., primary, Accordini, S., additional, Corsico, A., additional, Zoia, M.C., additional, Carrozzi, L., additional, Cazzoletti, L., additional, Beccaria, M., additional, Marinoni, A., additional, Viegi, G., additional, and de Marco, R., additional

Published
2003
Full Text
View/download PDF

43. The impact of climate and traffic-related NO2on the prevalence of asthma and allergic rhinitis in Italy

Author

De Marco, R., primary, Poli, A., additional, Ferrari, M., additional, Accordini, S., additional, Giammanco, G., additional, Bugiani, M., additional, Villani, S., additional, Ponzio, M., additional, Bono, R., additional, Carrozzi, L., additional, Cavallini, R., additional, Cazzoletti, L., additional, Dallari, R., additional, Ginesu, F., additional, Lauriola, P., additional, Mandrioli, P., additional, Perfetti, L., additional, Pignato, S., additional, Pirina, P., additional, and Struzzo, P., additional

Published
2002
Full Text
View/download PDF

46. The Gene-Environment Interactions in Respiratory Diseases (GEIRD) Project.

Author

de Marco, R., Accordini, S., Antonicelli, L., Bellia, V., Bettin, M. D., Bombieri, C., Bonifazi, F., Bugiani, M., Carosso, A., Casali, L., Cazzoletti, L., Cerveri, I., Corsico, A. G., Ferrari, M., Fois, A. G., Lo Cascio, V., Marcon, A., Marinoni, A., Olivieri, M., and Perbellini, L.

Subjects
RESPIRATORY diseases, ALLERGIC rhinitis, BIOMARKERS, PHENOTYPES, RHINITIS
Abstract

The role of genetic and environmental factors, as well as their interaction, in the natural history of asthma, allergic rhinitis and chronic obstructive pulmonary disease (COPD) is largely unknown. This is mainly due to the lack of large-scale analytical epidemiological/genetic studies aimed at investigating these 3 respiratory conditions simultaneously. The GEIRD project is a collaborative initiative designed to collect information on biomarkers of inflammation and oxidative stress, individual and ecological exposures, diet, early-life factors, smoking habits, genetic traits and medication use in large and accurately defined series of asthma, allergic rhinitis and COPD phenotypes. It is a population-based multicase-control design, where cases and controls are identified through a 2-stage screening process (postal questionnaire and clinical examination) in pre-existing cohorts or new samples of subjects. It is aimed at elucidating the role that modifiable and genetic factors play in the occurrence, persistence, severity and control of inflammatory airway diseases, by way of the establishment of a historical multicentre standardized databank of phenotypes, contributed by and openly available to international epidemiologists. Researchers conducting population-based surveys with standardized methods may contribute to the public-domain case-control database, and use the resulting increased power to answer their own scientific questions. Copyright © 2010 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]

Published
2010
Full Text
View/download PDF

47. The impact of climate and traffic-related NO2 on the prevalence of asthma and allergic rhinitis in Italy.

Author

de Marco, R., Poli, A., Ferrari, M., Accordini, S., Giammanco, G., Bugiani, M., Villani, S., Ponzio, M., Bono, R., Carrozzi, L., Cavallini, R., Cazzoletti, L., Dallari, R., Ginesu, F., Lauriola, P., Mandrioli, P., Perfetti, L., Pignato, S., Pirina, P., and Struzzo, P.

Subjects
ATMOSPHERIC nitrogen dioxide, ASTHMA, ALLERGIC rhinitis
Abstract

Summary Background Environmental factors are likely to be involved in explaining the wide geographical variation in asthma and atopic diseases that has been documented in many recent epidemiological studies. Aim To evaluate to what extent climate and outdoor NO2 pollution can explain the geographical variation in the prevalence of asthma and allergic rhinitis, and to estimate the relative risk for exposure to different levels of these two factors. Methods The impact of climate and long-term exposure to nitrogen dioxide (NO2 ) pollution on asthma and allergic rhinitis was assessed in a cross-sectional study, carried out during 1998 to 2000 on young adults aged 20 to 44 years ( n = 18 873), living in 13 areas from two different Italian climatic regions (subcontinental and Mediterranean). Results Mediterranean areas had a significantly higher prevalence of asthma-like symptoms (P < 0.001), higher annual mean temperature (16.2 °C vs. 12.9 °C), lower temperature range (16.0 C° vs. 22.1 C°) and lower NO 2 levels (31.46 µg/m 3 vs. 57.99 µg/m 3 ) than subcontinental ones. Mediterranean climate was associated with an increased risk of wheeze (OR = 1.23; 95% CI 1.13 to 1.35), tightness in the chest (OR = 1.21; 95% CI 1.11 to 1.33), shortness of breath (OR = 1.21; 95% CI 1.08 to 1.36) and asthma attacks (OR = 1.19; 95% CI 1.07 to 1.31). After adjusting for climate, an increase of 18.3 µg/m 3 in NO 2 levels moderately increased the risk of asthma attacks (OR = 1.13; 95% CI 0.98 to 1.32), tightness in the chest (OR = 1.11; 95% CI 0.98 to 1.26) and wheeze (OR = 1.11; 95% CI 0.96 to 1.28). When the levels of outdoor NO 2 exposure rose, the prevalence of allergic rhinitis increased significantly in the Mediterranean region (OR = 1.38; 95% CI 1.12 to 1.69), but not in the subcontinental one (OR = 1.03; 95% CI 0.83 to 1.28). Conclusion Our results show that... [ABSTRACT FROM AUTHOR]

Published
2002
Full Text
View/download PDF

48. Asthmatics and ex-smokers respond early, heavy smokers respond late to mailed surveys in Italy

Author

Verlato, Giuseppe, Melotti, Roberto, Olivieri, Mario, Corsico, Angelo, Bugiani, Massimiliano, Accordini, Simone, Villani, Simona, Migliore, Enrica, Marinoni, Alessandra, Pirina, Pietro, Carrozzi, Laura, Bortolami, Oscar, Rava, Marta, de Marco, Roberto, Accordini, S., Verlato, G., Zanolin, E., Bugiani, M., Buriani, O., Carrozzi, L., Dallari, R., Giammanco, G., Ginesu, F., Marinoni, A., Poli, A., Struzzo, Pierluigi, Cavallini, R., Saletti, C., Cellini, M., Faustini, M., de Togni, A., Carolei, A., Montomoli, C., Villani, S., Comelli, M., Ponzio, M., Grassi, M., Rezzani, C., Casali, L., Cerveri, I., Zoia, M. C., Corsico, A., Colato, S., Moscato, G., Perfetti, L., Viegi, G., Pistelli, F., Di Pede, F., Paggiaro, P. L., Santolicandro, A., Giovannetti, P., Pirina, P., Ostera, S., Pinna, G. P., Farre, A., Imparato, S., Turrini, E., Foglia, M., Pignato, S., Rotondo, A., Cuspilici, A., Piccioni, P., Carosso, A., Arossa, W., Caria, E., Castiglioni, G., Migliore, E., Romano, C., Fabbro, D., Ciccone, G., Magnani, C., Dalmasso, P., Bono, R., Gigli, G., Giraudo, A., Brussino, M. C., Bucca, C., Rolla, G., Struzzo, P., Orefice, U., Schneider, M., Chittaro, F., Peresson, D., de Marco, R., Zanolin, M. E., Locatelli, F., Cazzoletti, L., Pattaro, C., Sartori, S., Dorigo, N., Cantarelli, S., Ciresola, D., Lo Cascio, V., Ferrari, M., Biasin, C., Lauriola, P., Danielli, G., Sesti, D., Ghigli, E., Natale, P., Grosa, M., Tacconi, A., Frontero, P., Salomoni, A., Verlato, Giuseppe, Melotti, Roberto, Olivieri, Mario, Corsico, Angelo, Bugiani, Massimiliano, Accordini, Simone, Villani, Simona, Migliore, Enrica, Marinoni, Alessandra, Pirina, Pietro, Carrozzi, Laura, Bortolami, Oscar, Rava, Marta, de Marco, Roberto, Accordini, S., Verlato, G., Zanolin, E., Bugiani, M., Buriani, O., Carrozzi, L., Dallari, R., Giammanco, G., Ginesu, F., Marinoni, A., Poli, A., Struzzo, Pierluigi, Cavallini, R., Saletti, C., Cellini, M., Faustini, M., de Togni, A., Carolei, A., Montomoli, C., Villani, S., Comelli, M., Ponzio, M., Grassi, M., Rezzani, C., Casali, L., Cerveri, I., Zoia, M. C., Corsico, A., Colato, S., Moscato, G., Perfetti, L., Viegi, G., Pistelli, F., Di Pede, F., Paggiaro, P. L., Santolicandro, A., Giovannetti, P., Pirina, P., Ostera, S., Pinna, G. P., Farre, A., Imparato, S., Turrini, E., Foglia, M., Pignato, S., Rotondo, A., Cuspilici, A., Piccioni, P., Carosso, A., Arossa, W., Caria, E., Castiglioni, G., Migliore, E., Romano, C., Fabbro, D., Ciccone, G., Magnani, C., Dalmasso, P., Bono, R., Gigli, G., Giraudo, A., Brussino, M. C., Bucca, C., Rolla, G., Struzzo, P., Orefice, U., Schneider, M., Chittaro, F., Peresson, D., de Marco, R., Zanolin, M. E., Locatelli, F., Cazzoletti, L., Pattaro, C., Sartori, S., Dorigo, N., Cantarelli, S., Ciresola, D., Lo Cascio, V., Ferrari, M., Biasin, C., Lauriola, P., Danielli, G., Sesti, D., Ghigli, E., Natale, P., Grosa, M., Tacconi, A., Frontero, P., and Salomoni, A.

Subjects
Male, Questionnaires, Allergy, asthmatics, ex-smokers, survey, Allergic rhinitis, Mail survey, Epidemiology, Prevalence, Smoking habit, Medicine, Respiratory symptoms, Young adult, Response bias, Medicine (all), Respiratory disease, Phlegm, Smoking, Health Survey, Middle Aged, Chronic cough, Italy, Bias (Epidemiology), Female, medicine.symptom, Human, Adult, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Logistic Model, Response bia, Young Adult, Allergic rhiniti, Humans, Smoking habits, Asthma, Questionnaire, business.industry, medicine.disease, Health Surveys, Surgery, respiratory tract diseases, Logistic Models, Cough, mail survey, response bias, respiratory symptoms, asthma, allergic rhinitis, smoking habits, Respiratory symptom, Patient Compliance, business, Demography
Abstract

Summary Rationale and objectives Response to mailed epidemiological surveys has decreased in recent decades. Since subjects with respiratory symptoms are usually early responders to surveys performed in Southern Europe, this trend could bias prevalence estimates. The present study aimed at evaluating the impact of non-response bias on prevalence estimates of respiratory symptoms and smoking habits. Methods In 9 centres, participating in the Italian Study on Asthma in Young Adults (ISAYA), random samples of people aged 20–45 years were administered a mailed questionnaire between 1998 and 2000. Non-responders were contacted again first by mail and then by phone. Cumulative response percentage was 30.5%, 52.4% and 72.7% (18,873/25,969), respectively, after the 1st, 2nd and 3rd contact. Results The prevalence of self-reported current asthma, asthma-like symptoms, and chronic cough/phlegm was more than halved from the first contact (5.6%, 17.8%, 14.6% respectively) to the third contact (2.7%, 6.4%, 6.9%). This pattern was less pronounced when considering allergic rhinitis and past asthma, whose prevalence decreased, respectively, from 21.5% to 15.6% and from 3.5% to 2.6%. At the same time the proportion of current smokers increased from 29.2% to 38%, while the proportion of ex-smokers decreased from 16.5% to 10.1%. In a multinomial logistic model current asthma, asthma-like symptoms, chronic cough/phlegm and smoking habits, and to a lower extent past asthma and allergic rhinitis, were significant predictors of late response. Conclusions In Italy when response percentage is low, the prevalence of current asthma, chronic cough/phlegm and ex-smokers is overestimated, while the proportion of current smokers is underestimated.

Full Text
View/download PDF

50. Chronic bronchitis without airflow obstruction, asthma and rhinitis are differently associated with cardiovascular risk factors and diseases

Author

Pietro Pirina, Pierpaolo Marchetti, Giulia Squillacioti, Elia Piccinno, Giuseppe Verlato, Salvatore Battaglia, Amelia Grosso, Alessandro Marcon, Giancarlo Pesce, Marcello Ferrari, Lucia Cazzoletti, Leonardo Antonicelli, Ferrari M., Piccinno E., Marcon A., Marchetti P., Cazzoletti L., Pirina P., Battaglia S., Grosso A., Squillacioti G., Antonicelli L., Verlato G., Pesce G., Bodescot, Myriam, Unit of Respiratory Medicine [Vérone, Italie], Department of Diagnostics and Public Health [Verona] (UNIVR | DDSP), Università degli studi di Verona = University of Verona (UNIVR)-Università degli studi di Verona = University of Verona (UNIVR), Unit of Epidemiology and Medical Statistics [Vérone, Italie], Department of Diagnostics and Public Health [Vérone, Italie], Unità Operativa di Pneumologia [Sassari, Italie], Dipartimento di Scienze Mediche, Chirurgiche e Sperimentali [Sassari, Italie], Università degli Studi di Sassari = University of Sassari [Sassari] (UNISS)-Università degli Studi di Sassari = University of Sassari [Sassari] (UNISS), Dipartimento Universitario di Promozione della Salute, Materno Infantile, Medicina Interna e Specialistica di Eccellenza 'G. D'Alessandro' [Palerme, Italie] (PROMISE), Università degli studi di Palermo - University of Palermo, Division of Respiratory Diseases [Pavie, Italie], IRCCS 'San Matteo' Hospital Foundation [Pavie, Italie], Università degli Studi di Pavia = University of Pavia (UNIPV)-Università degli Studi di Pavia = University of Pavia (UNIPV), Department of Public Health and Pediatrics [Turin, Italie], Università degli studi di Torino = University of Turin (UNITO), Allergy Unit [Ancône, Italie], Department of Internal Medicine [Ancône, Italie], Azienda Ospedaliero-Universitaria Ospedali Riuniti [Ancône, Italie]-Azienda Ospedaliero-Universitaria Ospedali Riuniti [Ancône, Italie], Epidemiology of Allergic and Respiratory Diseases Department [iPlesp] (EPAR), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), The GEIRD study was funded by the Cariverona foundation, the Italian Ministry of Health, Chiesi Farmaceutici SpA, and the Agenzia Italiana del Farmaco (AIFA)., University of Verona (UNIVR)-University of Verona (UNIVR), Università degli Studi di Sassari [Sassari] (UNISS)-Università degli Studi di Sassari [Sassari] (UNISS), University of Pavia-University of Pavia, University of Turin, Epidemiology of Allergic and Respiratory Diseases Department [Paris] (EPAR), and Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
Male, LUNG-DISEASE, Chronic bronchitis, Pulmonology, Epidemiology, Blood Pressure, Cardiovascular Medicine, 030204 cardiovascular system & hematology, Vascular Medicine, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, Cohort Studies, Pulmonary Disease, Chronic Obstructive, 0302 clinical medicine, Risk Factors, Medicine and Health Sciences, Odds Ratio, chronic bronchiti, Lung, Rhinitis, Aged, 80 and over, education.field_of_study, Alcohol Consumption, Multidisciplinary, Heart, Middle Aged, Cardiovascular disease, CB, Respiratory Function Tests, 3. Good health, PREVALENCE, [SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Bronchitis, Chronic, ALLERGIC RHINITIS, INTERMITTENT CLAUDICATION, Cardiovascular Diseases, Hypertension, Bronchitis, Medicine, chronic bronchitis, Female, Anatomy, medicine.symptom, Research Article, Adult, medicine.medical_specialty, Science, Population, body mass index, Settore MED/10 - Malattie Dell'Apparato Respiratorio, DIAGNOSIS, elderly, chronic obstructive pulmonary disease, Young Adult, 03 medical and health sciences, Heart disorder, BMI, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Internal medicine, Confidence Intervals, medicine, Humans, COPD, CORONARY-HEART-DISEASE, education, Nutrition, Aged, Asthma, MYOCARDIAL-INFARCTION, MUCUS HYPERSECRETION, CIGARETTE-SMOKING, ATHEROSCLEROSIS, business.industry, Biology and Life Sciences, Odds ratio, Rhinology, asthma, medicine.disease, Intermittent claudication, Diet, Otorhinolaryngology, 030228 respiratory system, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Medical Risk Factors, Case-Control Studies, Relative risk, Nasal Diseases, Cardiovascular Anatomy, [SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, BMI, body mass index, CB, chronic bronchitis, COPD, chronic obstructive pulmonary disease
Abstract

Background and objectives Cardiovascular and respiratory diseases can frequently coexist. Understanding their link may improve disease management. We aimed at assessing the associations of chronic bronchitis (CB), asthma and rhinitis with cardiovascular diseases and risk factors in the general population. Methods We used data collected in the Gene Environment Interactions in Respiratory Diseases study, an Italian multicentre, multicase-control study. Among 2463 participants (age 21–86, female 50%) who underwent standardized interviews, skin prick and lung function tests, we identified 254 cases of CB without airflow obstruction, 418 cases of asthma without CB, 959 cases of rhinitis alone, and 832 controls. The associations of respiratory diseases with reported cardiovascular risk factors (lifestyles, hypertension, dyslipidaemia), heart disorders (myocardial infarction, coronary thrombosis, angina, aorta or heart surgery) and intermittent claudication were estimated through relative risk ratios (RRR) by multinomial logistic regression models. Results Compared to controls, CB cases were more likely to be heavy smokers, alcohol consumers, physically inactive, and to suffer from hypertension or dyslipidaemia; rhinitis cases were less obese but more likely to have hypertension. Asthma was significantly associated with current smoking. After adjusting for cardiovascular risk factors, heart disorders were associated with CB (RRR[95%CI]: 1.58[1.12–2.22]) and rhinitis (1.35[0.98–1.85]) and intermittent claudication was associated with CB (3.43[2.52–4.67]), asthma (1.51[1.04–2.21]) and rhinitis (2.03[1.34–3.07]). Conclusions CB, asthma and rhinitis were associated with cardiovascular risk factors and diseases. In particular, CB shared with cardiovascular diseases almost all risk factors and was strongly associated with a higher risk of heart disorders and intermittent claudication.

Published
2019

Catalog

Books, media, physical & digital resources
See catalog results