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1. Corrigendum: Real-practice management and treatment of idiopathic multicentric Castleman disease with siltuximab: a collection of clinical experiences

Author

Rossini, Bernardo, primary, Cecchi, Nicola, additional, Clemente, Felice, additional, Rosaria De Paolis, Maria, additional, Hohaus, Stefan, additional, Innao, Vanessa, additional, Lucignano, Mariano, additional, Massaiu, Roberto, additional, Palumbo, Giovanna, additional, Rigolin, Gian Matteo, additional, Rossi, Francesca Gaia, additional, Verga, Luisa, additional, and Guarini, Attilio, additional

Published
2024
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2. Bioactives in Oral Nutritional Supplementation: A Pediatric Point of View.

Author

Cecchi, Nicola, Romanelli, Roberta, Ricevuti, Flavia, Carbone, Maria Grazia, Dinardo, Michele, Cesarano, Elisabetta, De Michele, Alfredo, Messere, Giovanni, Morra, Salvatore, Scognamiglio, Armando, and Spagnuolo, Maria Immacolata

Abstract

Background: Oral nutritional supplements (ONSs) are crucial for supporting the nutritional needs of pediatric populations, particularly those with medical conditions or dietary deficiencies. Bioactive compounds within ONSs play a pivotal role in enhancing health outcomes by exerting various physiological effects beyond basic nutrition. However, the comprehensive understanding of these bioactives in pediatric ONSs remains elusive. Objective: This systematic narrative review aims to critically evaluate the existing literature concerning bioactive compounds present in oral nutritional supplements from a pediatric standpoint, focusing on their types, sources, bioavailability, physiological effects, and clinical implications. Methods: A systematic search was conducted across the major academic databases, including PubMed, Scopus, and Web of Science, employing predefined search terms related to oral nutritional supplements, bioactives, and pediatrics. Studies published between 2013 and 2024 were considered eligible for inclusion. Data extraction and synthesis were performed according to the PRISMA guidelines. Results: The initial search yielded 558 of articles, of which 72 met the inclusion criteria. The included studies encompassed a diverse range of bioactive compounds present in pediatric ONS formulations, including, but not limited to, vitamins, minerals, amino acids, prebiotics, probiotics, and phytonutrients. These bioactives were sourced from various natural and synthetic origins and were found to exert beneficial effects on growth, development, immune function, gastrointestinal health, cognitive function, and overall well-being in pediatric populations. However, variations in bioavailability, dosing, and clinical efficacy were noted across different compounds and formulations. Conclusions: Bioactive compounds in oral nutritional supplements offer promising avenues for addressing the unique nutritional requirements and health challenges faced by pediatric populations. However, further research is warranted to elucidate the optimal composition, dosage, and clinical applications of these bioactives in pediatric ONS formulations. A deeper understanding of these bioactive compounds and their interplay with pediatric health may pave the way for personalized and effective nutritional interventions in pediatric clinical practice. [ABSTRACT FROM AUTHOR]

Published
2024
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7. P-191 - Allogeneic hematopoietic stem cell transplantation in patients with advanced mycosis fungoides and Sézary syndrome: 2023 update of the Milan experience

Author

Onida, Francesco, Cavallaro, Francesca, Violetti, Silvia Alberti, Goldaniga, Maria, Barbullushi, Kordelia, Galassi, Giulia, Serpenti, Fabio, Cecchi, Nicola, Bellani, Valentina, Cassanello, Giulio, Galli, Nicole, Versino, Francesco, Rampi, Nicolò, Bosi, Alessandro, Croci, Giorgio Alberto, Simontacchi, Gabriele, Berti, Emilio, and Saporiti, Giorgia

Published
2023
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9. Thrombotic and Infectious Complications in Patients with Autoimmune Hemolytic Anemia: A Multicenter Observational Study

Author

Fattizzo, Bruno, primary, Cecchi, Nicola, additional, Tamellini, Edoardo, additional, Morelli, Francesca, additional, Tanasi, Ilaria, additional, Di Perna, Maria, additional, Raso, Simona, additional, Gardellini, Angelo, additional, Lame, Dorela, additional, Laurino, Marica, additional, Mulas, Olga, additional, Rana, Antonello, additional, Bianchi, Paola, additional, and Barcellini, Wilma, additional

Published
2022
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10. Thrombopoietin receptor agonists in adult Evans syndrome: an international multicenter experience

Author

Fattizzo, Bruno, primary, Cecchi, Nicola, additional, Bortolotti, Marta, additional, Giordano, Giulio, additional, Patriarca, Andrea, additional, Glenthøj, Andreas, additional, Cantoni, Silvia, additional, Capecchi, Marco, additional, Chen, Frederick, additional, Mingot-Castellano, Maria Eva, additional, Napolitano, Mariasanta, additional, Frederiksen, Henrik, additional, Gonzaléz-Lopez, Tomàs José, additional, and Barcellini, Wilma, additional

Published
2022
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11. Thrombopoietin receptor agonists in adult Evans syndrome:an international multicenter experience

Author

Fattizzo, Bruno, Cecchi, Nicola, Bortolotti, Marta, Giordano, Giulio, Patriarca, Andrea, Glenthøj, Andreas, Cantoni, Silvia, Capecchi, Marco, Chen, Frederick, Mingot-Castellano, Maria Eva, Napolitano, Mariasanta, Frederiksen, Henrik, Gonzaléz-Lopez, Tomàs José, Barcellini, Wilma, Fattizzo, Bruno, Cecchi, Nicola, Bortolotti, Marta, Giordano, Giulio, Patriarca, Andrea, Glenthøj, Andreas, Cantoni, Silvia, Capecchi, Marco, Chen, Frederick, Mingot-Castellano, Maria Eva, Napolitano, Mariasanta, Frederiksen, Henrik, Gonzaléz-Lopez, Tomàs José, and Barcellini, Wilma

Published
2022

15. Efficacy of Thrombopoietin Receptor Agonists in Evans Syndrome: An International Multicenter Experience

Author

Cecchi, Nicola, primary, Giannotta, Juri Alessandro, additional, Patriarca, Andrea, additional, Glenthøj, Andreas, additional, Mingot, Maria Eva, additional, Chen, Frederick, additional, Cantoni, Silvia, additional, Lund Hansen, Dennis, additional, Capecchi, Marco, additional, Frederiksen, Henrik, additional, Gonzalez-Lopez, Tomas Jose, additional, Barcellini, Wilma, additional, and Fattizzo, Bruno, additional

Published
2021
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22. A case of severe aplastic anaemia after SARS‐CoV‐2 vaccination.

Author

Cecchi, Nicola, Giannotta, Juri Alessandro, Barcellini, Wilma, and Fattizzo, Bruno

Subjects
*APLASTIC anemia, *PAROXYSMAL hemoglobinuria, *SARS-CoV-2, *VACCINATION, *AUTOIMMUNE hemolytic anemia, *COVID-19
Abstract

Additionally, causes of secondary AA other than SARS-CoV-2 infection/vaccine should not be disregarded, including other infections, drugs, and the rarer congenital bone marrow failures. Keywords: aplastic anaemia; autoimmune haemolytic anaemia; immune thrombocytopenia; coronavirus disease 2019; severe acute respiratory syndrome coronavirus-2 vaccine EN aplastic anaemia autoimmune haemolytic anaemia immune thrombocytopenia coronavirus disease 2019 severe acute respiratory syndrome coronavirus-2 vaccine 1334 1336 3 03/22/22 20220315 NES 220315 There is increasing awareness about the possible relationship between severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) vaccines and the development of haematological diseases, including autoimmune cytopenias (AICs) and complement-mediated diseases. Immune thrombocytopenia, severe acute respiratory syndrome coronavirus-2 vaccine, aplastic anaemia, autoimmune haemolytic anaemia, coronavirus disease 2019. [Extracted from the article]

Published
2022
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23. Paediatric Home Artificial Nutrition in Italy: Report from 2016 Survey on Behalf of Artificial Nutrition Network of Italian Society for Gastroenterology, Hepatology and Nutrition (SIGENP)

Author

Lezo, Antonella, primary, Capriati, Teresa, additional, Spagnuolo, Maria, additional, Lacitignola, Laura, additional, Goreva, Irina, additional, Di Leo, Grazia, additional, Cecchi, Nicola, additional, Gandullia, Paolo, additional, Amarri, Sergio, additional, Forchielli, Maria, additional, Dipasquale, Valeria, additional, Parma, Barbara, additional, Gatti, Simona, additional, Ravaioli, Elisa, additional, Salvatore, Silvia, additional, Mainetti, Martina, additional, Norsa, Lorenzo, additional, Pellegrino, Maristella, additional, Fornaro, Martina, additional, Fiorito, Valentina, additional, Lanari, Marcello, additional, Giaquinto, Ester, additional, Verduci, Elvira, additional, Baldassarre, Maria, additional, and Diamanti, Antonella, additional

Published
2018
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24. Pediatric Chronic Intestinal Failure in Italy: Report from the 2016 Survey on Behalf of Italian Society for Gastroenterology, Hepatology and Nutrition (SIGENP)

Author

Diamanti, Antonella, primary, Capriati, Teresa, additional, Gandullia, Paolo, additional, Di Leo, Grazia, additional, Lezo, Antonella, additional, Lacitignola, Laura, additional, Spagnuolo, Maria, additional, Gatti, Simona, additional, D’Antiga, Lorenzo, additional, Verlato, Giovanna, additional, Roggero, Paola, additional, Amarri, Sergio, additional, Baldassarre, Maria, additional, Cirillo, Francesco, additional, Elia, Domenica, additional, Boldrini, Renata, additional, Campanozzi, Angelo, additional, Catassi, Carlo, additional, Aloi, Marina, additional, Romano, Claudio, additional, Candusso, Manila, additional, Cecchi, Nicola, additional, Bellini, Tommaso, additional, Tyndall, Elaine, additional, Fusaro, Fabio, additional, Caldaro, Tamara, additional, Alberti, Daniele, additional, Gamba, Piergiorgio, additional, Lima, Mario, additional, Bagolan, Pietro, additional, De Ville de Goyet, Jean, additional, Dall’Oglio, Luigi, additional, Spada, Marco, additional, and Grandi, Francesca, additional

Published
2017
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25. Real-practice management and treatment of idiopathic multicentric Castleman disease with siltuximab: a collection of clinical experiences

Author

Rossini, Bernardo, primary, Cecchi, Nicola, additional, Clemente, Felice, additional, De Paolis, Maria Rosaria, additional, Hohaus, Stefan, additional, Innao, Vanessa, additional, Lucignano, Mariano, additional, Massaiu, Roberto, additional, Palumbo, Giovanna, additional, Rigolin, Gian Matteo, additional, Rossi, Francesca Gaia, additional, Verga, Luisa, additional, and Guarini, Attilio, additional

Published
2014
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26. Thrombopoietin receptor agonists in adult Evans syndrome: an international multicenter experience

Author

Bruno Fattizzo, Nicola Cecchi, Marta Bortolotti, Giulio Giordano, Andrea Patriarca, Andreas Glenthøj, Silvia Cantoni, Marco Capecchi, Frederick Chen, Maria Eva Mingot-Castellano, Mariasanta Napolitano, Henrik Frederiksen, Tomàs José Gonzaléz-Lopez, Wilma Barcellini, [Fattizzo, Bruno] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Via Sforza 35, I-20122 Milan, Italy, [Cecchi, Nicola] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Via Sforza 35, I-20122 Milan, Italy, [Bortolotti, Marta] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Via Sforza 35, I-20122 Milan, Italy, [Capecchi, Marco] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Via Sforza 35, I-20122 Milan, Italy, [Barcellini, Wilma] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Via Sforza 35, I-20122 Milan, Italy, [Fattizzo, Bruno] Univ Milan, Dept Oncol & Hematooncol, Milan, Italy, [Cecchi, Nicola] Univ Milan, Dept Oncol & Hematooncol, Milan, Italy, [Bortolotti, Marta] Univ Milan, Dept Oncol & Hematooncol, Milan, Italy, [Capecchi, Marco] Univ Milan, Dept Oncol & Hematooncol, Milan, Italy, [Giordano, Giulio] Med Serv & Ambulatorio Ematol Osped Riferimento, Unita Operat Complessa UOC, Campobasso, Italy, [Patriarca, Andrea] Univ Piemonte Orientale, Dept Translat Med, Novara, Italy, [Patriarca, Andrea] Copenhagen Univ Hosp, Dept Hematol, Rigshosp, Copenhagen, Denmark, [Cantoni, Silvia] Niguarda Canc Ctr, Azienda Socio Sanitaria Territoriale ASST Grande, Milan, Italy, [Chen, Frederick] Clin Haematol, Barts Hlth Natl Hlth Serv NHS Trust & Queen Mary, London, England, [Mingot-Castellano, Maria Eva] Univ Virgen Rocio, Area Banco Sangre Establecimiento Tejidos Hosp, Serv Hematol, Seville, Spain, [Napolitano, Mariasanta] Univ Palermo, Dept Hlth Promot Mother & Child Care, Internal Med & Med Specialties ProMISE, Palermo, Italy, [Frederiksen, Henrik] Odense Univ Hosp, Dept Hematol, Odense, Denmark, [Jose Gonzalez-Lopez, Tomas] Hosp Univ Burgos, Serv Hematol, Burgos, Spain, Italian Ministry of Health Current Research Grant, Fattizzo, Bruno, Cecchi, Nicola, Bortolotti, Marta, Giordano, Giulio, Patriarca, Andrea, Glenthøj, Andrea, Cantoni, Silvia, Capecchi, Marco, Chen, Frederick, Mingot-Castellano, Maria Eva, Napolitano, Mariasanta, Frederiksen, Henrik, Gonzaléz-Lopez, Tomàs José, and Barcellini, Wilma

Subjects
Adult, Purpura, Thrombocytopenic, Idiopathic, Recombinant Fusion Proteins, Immunology, Severe thrombocytopenia, Cell Biology, Hematology, Receptors, Fc, Biochemistry, Benzoates, Thrombocytopenia, Benzoate, Hydrazines, Thrombopoietin, Eltrombopag, Hydrazine, Humans, Anemia, Hemolytic, Autoimmune, Receptors, Thrombopoietin, Human, Recombinant Fusion Protein
Published
2022
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27. Pediatric chronic intestinal failure in italy: Report from the 2016 survey on behalf of Italian society for gastroenterology, hepatology and nutrition (SIGENP)

Author

Luigi Dall'Oglio, Paolo Gandullia, Fabio Fusaro, Antonella Diamanti, Antonella Lezo, Paola Roggero, Elaine Tyndall, Giovanna Verlato, Manila Candusso, Tamara Caldaro, Carlo Catassi, Daniele Alberti, Sergio Amarri, Claudio Romano, Maria Immacolata Spagnuolo, Mario Lima, Pietro Bagolan, Lorenzo D'Antiga, Nicola Cecchi, Grazia Di Leo, Domenica Elia, Francesca Grandi, Jean de Ville de Goyet, Marina Aloi, Simona Gatti, Renata Boldrini, Tommaso Bellini, Teresa Capriati, F. Cirillo, Maria Elisabetta Baldassarre, Marco Spada, Angelo Campanozzi, Piergiorgio Gamba, Laura Lacitignola, DIPARTIMENTO DI SCIENZE MEDICHE E CHIRURGICHE, Facolta' di MEDICINA e CHIRURGIA, Da definire, AREA MIN. 06 - Scienze mediche, Diamanti, Antonella, Capriati, Teresa, Gandullia, Paolo, Dileo, Grazia, Lezo, Antonella, Lacitignola, Laura, Spagnuolo, Mariaimmacolata, Gatti, Simona, Dâ antiga, Lorenzo, Verlato, Giovanna, Roggero, Paola, Amarri, Sergio, Baldassarre, Mariaelisabetta, Cirillo, Francesco, Elia, Domenica, Boldrini, Renata, Campanozzi, Angelo, Catassi, Carlo, Aloi, Marina, Romano, Claudio, Candusso, Manila, Cecchi, Nicola, Bellini, Tommaso, Tyndall, Elaine, Fusaro, Fabio, Caldaro, Tamara, Alberti, Daniele, Gamba, Piergiorgio, Lima, Mario, Bagolan, Pietro, De Goyet, Jean De Ville, Dallâ oglio, Luigi, Spada, Marco, and Grandi, Francesca

Subjects
Male, Children, Home parenteral nutrition, Intestinal failure, Food Science, Nutrition and Dietetics, medicine.medical_specialty, Pediatrics, Adolescent, Nutritional Status, lcsh:TX341-641, Article, 03 medical and health sciences, 0302 clinical medicine, 030225 pediatrics, Internal medicine, Epidemiology, Prevalence, medicine, Humans, Child, Child, Preschool, Chronic Disease, Data Collection, Female, Incidence, Infant, Intestinal Diseases, Italy, Parenteral Nutrition, Home, Pediatric gastroenterology, Settore MED/38 - Pediatria Generale e Specialistica, business.industry, Incidence (epidemiology), Hepatology, Chronic intestinal failure, children, home parenteral nutrition, intestinal failure, Parenteral nutrition, 030211 gastroenterology & hepatology, Residence, business, lcsh:Nutrition. Foods and food supply, Developed country
Abstract

none 34 no Background: Intestinal failure (IF) is the reduction in functioning gut mass below the minimal level necessary for adequate digestion and absorption of nutrients and fluids for weight maintenance in adults or for growth in children. There is a paucity of epidemiologic data on pediatric IF. The purpose of this study was to determine the prevalence, incidence, regional distribution and underlying diagnosis of pediatric chronic IF (CIF) requiring home parenteral nutrition (HPN) in Italy. Methods: Local investigators were selected in 19 Italian centers either of reference for pediatric HPN or having pediatric gastroenterologists or surgeons on staff and already collaborating with the Italian Society for Pediatric Gastroenterology, Hepatology and Nutrition with regard to IF. Data requested in this survey for children at home on Parenteral Nutrition (PN) on 1 December 2016 included patient initials, year of birth, gender, family’s place of residence and underlying diagnosis determining IF. Results: We recorded 145 CIF patients on HPN aged ≤19 years. The overall prevalence was 14.12/million inhabitants (95% CI: 9.20–18.93); the overall incidence was 1.41/million inhabitant years (95% CI: 0.53–2.20). Conclusion: Our survey provides new epidemiological data on pediatric CIF in Italy; these data may be quantitatively useful in developing IF care strategy plans in all developed countries. open Diamanti, Antonella; Capriati, Teresa; Gandullia, Paolo; Dileo, Grazia; Lezo, Antonella; Lacitignola, Laura; Spagnuolo, Mariaimmacolata; Gatti, Simona; D’antiga, Lorenzo; Verlato, Giovanna; Roggero, Paola; Amarri, Sergio; Baldassarre, Mariaelisabetta; Cirillo, Francesco; Elia, Domenica; Boldrini, Renata; Campanozzi, Angelo; Catassi, Carlo; Aloi, Marina; Romano, Claudio; Candusso, Manila; Cecchi, Nicola; Bellini, Tommaso; Tyndall, Elaine; Fusaro, Fabio; Caldaro, Tamara; Alberti, Daniele; Gamba, Piergiorgio; Lima, Mario; Bagolan, Pietro; De Goyet, Jean De Ville; Dall’oglio, Luigi; Spada, Marco; Grandi, Francesca Diamanti, Antonella; Capriati, Teresa; Gandullia, Paolo; Dileo, Grazia; Lezo, Antonella; Lacitignola, Laura; Spagnuolo, Mariaimmacolata; Gatti, Simona; Dâ antiga, Lorenzo; Verlato, Giovanna; Roggero, Paola; Amarri, Sergio; Baldassarre, Mariaelisabetta; Cirillo, Francesco; Elia, Domenica; Boldrini, Renata; Campanozzi, Angelo; Catassi, Carlo; Aloi, Marina; Romano, Claudio; Candusso, Manila; Cecchi, Nicola; Bellini, Tommaso; Tyndall, Elaine; Fusaro, Fabio; Caldaro, Tamara; Alberti, Daniele; Gamba, Piergiorgio; Lima, Mario; Bagolan, Pietro; De Goyet, Jean De Ville; Dallâ oglio, Luigi; Spada, Marco; Grandi, Francesca

Published
2017

28. Paediatric Home Artificial Nutrition in Italy: Report from 2016 Survey on Behalf of Artificial Nutrition Network of Italian Society for Gastroenterology, Hepatology and Nutrition (SIGENP)

Author

Martina Mainetti, Simona Gatti, Ester Giaquinto, Sergio Amarri, Antonella Lezo, Laura Lacitignola, Maria Immacolata Spagnuolo, Maristella Pellegrino, Martina Fornaro, Maria Elisabetta Baldassarre, Maria Luisa Forchielli, B. Parma, Lorenzo Norsa, Paolo Gandullia, Irina Goreva, Marcello Lanari, Elisa Ravaioli, Teresa Capriati, Nicola Cecchi, Valeria Dipasquale, Grazia Di Leo, Silvia Salvatore, Antonella Diamanti, Elvira Verduci, Valentina Fiorito, Lezo, Antonella, Capriati, Teresa, Spagnuolo, Maria Immacolata, Lacitignola, Laura, Goreva, Irina, Di Leo, Grazia, Cecchi, Nicola, Gandullia, Paolo, Amarri, Sergio, Forchielli, Maria Luisa, Dipasquale, Valeria, Parma, Barbara, Gatti, Simona, Ravaioli, Elisa, Salvatore, Silvia, Mainetti, Martina, Norsa, Lorenzo, Pellegrino, Maristella, Fornaro, Martina, Fiorito, Valentina, Lanari, Marcello, Giaquinto, Ester, Verduci, Elvira, Baldassarre, Maria Elisabetta, and Diamanti, Antonella

Subjects
Home Care Service, Male, 0301 basic medicine, Time Factors, Children, Home enteral nutrition, Home parenteral nutrition, Oral nutritional supplements, Pediatrics, 0302 clinical medicine, Quality of life, Epidemiology, Age Factor, Child, Pediatric, Nutrition and Dietetics, Incidence (epidemiology), Age Factors, Home Care Services, Nutritional Statu, Italy, Child, Preschool, oral nutritional supplements, population characteristics, Female, 030211 gastroenterology & hepatology, Child Nutritional Physiological Phenomena, Parenteral Nutrition, Home, lcsh:Nutrition. Foods and food supply, geographic locations, Human, medicine.medical_specialty, Adolescent, Time Factor, Demographics, MEDLINE, Nutritional Status, lcsh:TX341-641, Oral nutritional supplement, Artificial nutrition, Article, Young Adult, 03 medical and health sciences, Enteral Nutrition, Internal medicine, medicine, Humans, 030109 nutrition & dietetics, business.industry, Infant, Newborn, nutritional and metabolic diseases, Infant, Hepatology, eye diseases, stomatognathic diseases, Parenteral nutrition, Health Care Survey, Health Care Surveys, Family medicine, business, Food Science
Abstract

Home Artificial Nutrition (HAN) is a safe and efficacious technique that insures children&rsquo, s reintegration into the family, society and school. Epidemiological data on paediatric HAN in Italy are not available. Aim: to detect the prevalence and incidence of Home Parenteral Nutrition (HPN) and Home Enteral Nutrition (HEN), either via tube or mouth, in Italy in 2016. Materials and methods: a specific form was sent to all registered SIGENP members and investigators of local HAN centres, inviting them to provide the requested centre&rsquo, s data and demographics, underlying diseases and HAN characteristics of the patients. Results: we recorded 3403 Italian patients on HAN aged 0 to 19 years from 22 centres: 2277 HEN, 950 Oral Nutritional Supplements (ONS) and 179 HPN programs. The prevalence of HEN (205 pts/million inhabitants) and HPN (16 pts/million inhabitants) has dramatically increased in Italy in the last 9 years. Neurodisabling conditions were the first indication for HEN by tube or mouth while HPN is mainly requested in digestive disorders. Conclusions: HAN is a widespread and rapidly growing treatment in Italy, as well as in other European countries. Awareness of its extent and characteristics helps improving HAN service and patients&rsquo, quality of life.

Published
2018
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29. Real-practice management and treatment of idiopathic multicentric Castleman disease with siltuximab: a collection of clinical experiences.

Author

Rossini B, Cecchi N, Clemente F, De Paolis MR, Hohaus S, Innao V, Lucignano M, Massaiu R, Palumbo G, Rigolin GM, Rossi FG, Verga L, and Guarini A

Abstract

Castleman disease (CD) is a group of lymphoproliferative disorders that share common histopathological features yet have widely different aetiologies, clinical features and grades of severity as well as treatments and outcomes. Siltuximab is currently the only therapy approved by the FDA and EMA for idiopathic multicentric CD and is recommended as first-line therapy in treatment guidelines. Despite the extensive characterization of siltuximab treatment in clinical trials, available evidence from real-world practice is still scant. This collection of clinical experiences focuses on patients treated with siltuximab therapy, particularly regarding the idiopathic multicentric CD diagnostic work-up, and on treatment administration in patients with complex disease entering differential diagnosis with CD or concomitant diseases. Thus, these data help further characterize and improve the use of siltuximab in real practice in terms of effectiveness and safety of long-term administration as well as consequences of treatment interruption., Competing Interests: Disclosure and potential conflicts of interest: The authors declare that they have no conflicts of interest relevant to this manuscript. The International Committee of Medical Journal Editors (ICMJE) Potential Conflicts of Interests form for the authors is available for download at: https://www.drugsincontext.com/wp-content/uploads/2024/02/dic.2023-9-4-COI.pdf, (Copyright © 2024 Rossini B, Cecchi N, Clemente F, De Paolis MR, Hohaus S, Innao V, Lucignano M, Massaiu R, Palumbo G, Rigolin GM, Rossi FG, Verga L, Guarini A.)

Published
2024
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