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Yacon (Smallanthus sonchifolius) is a root-based fruit type which has been used for centuries as a staple food among the Andean population. In South America it is a traditional food, but in the European Union it is considered novel. It has a long history of safe use in South America and even elsewhere with potential health-promoting properties including prebiotic, antidiabetic, antioxidative and antimicrobial effects. Due to its status in Europe, yacon has to be assessed for its safety before being introduced on the European market. Since the latest novel food regulations accept history of safe use data from outside Europe, research has been conducted to establish whether yacon meets the regulatory requirements and can be authorized in Europe. Yacon has a well-documented and unambiguous history of safe use and its composition involves no obvious concerns in terms of detrimental effects, toxic substances or antinutrients. [ABSTRACT FROM AUTHOR]

The characterization of gut microbiota has become an important area of research in several clinical conditions, including type 2 diabetes (T2DM). Changes in the composition and/or metabolic activity of the gut microbiota can contribute to human health. Thus, this review discusses the effects of probiotics and gut microbiota on metabolic control in these individuals. Relevant studies were obtained from electronic databases such as PubMed/Medline and ISI Web of Science. The main probiotics used in these studies belonged to the genera Lactobacillus and Bifidobacterium. The authors found seven randomized placebo-controlled clinical trials and 13 experimental studies directly related to the effect of probiotics on metabolic control in the context of T2DM. The hypothesis that gut microbiota plays a role in the development of diabetes indicates an important beginning, and the potential of probiotics to prevent and reduce the severity of T2DM is better observed in animal studies. In clinical trials, the use of probiotics in glycemic control presented conflicting results, and only few studies have attempted to evaluate factors that justify metabolic changes, such as markers of oxidative stress, inflammation, and incretins. Thus, further research is needed to assess the effects of probiotics in the metabolism of diabetic individuals, as well as the main mechanisms involved in this complex relationship. [ABSTRACT FROM AUTHOR]

Research and innovation policies have been increasingly ascribed to regions as a con- sequence of devolving power and resources from the national level to the local level. Local administrators have been empowered with new and challenging responsibilities but often lack the necessary instruments and knowledge to adequately evaluate the under- taken initiatives and to operate consistently with the European and national dimensions. In this respect impact assessment brings in a new metrics that is neither exclusively related to the scientific and/or economic value of the innovation results nor to a support function to other policies. Experts and/or ad hoc organisations are often appointed by local administrations with the task of describing the dimensions of such impact - qualifying (and quantifying) its descriptive parameters and identifying interested parties. So far this approach has not produced robust results as for the causality links generated, the additionality issue and the role of the local dimension, while the available tool-box is quite poor. This paper is intended to illustrate the results of a pilot experience carried out in the last few years in Trentino. The analysis takes into account the relations among policy makers, available tools, resources, and the role of the public administration and of professional evaluators. Conceptual and interpretative approaches and tools need further development, but the mayor weakness seems to come from the relationship between customer-and evaluators. A new market based on new rules, professional roles and shared behaviours is needed in order to address a correct evaluation pathway and to analyse policies and activities within a common frame. [ABSTRACT FROM AUTHOR]

Gut colonisation with bifidobacteria in early infancy is essential for the well-being of the infant. Gestational age and mode of delivery are among the factors influencing the colonisation process. The aim was to characterise the bifidobacterial composition in the gut of one-month-old full-term and pre-term Brazilian infants, both being delivered vaginally or by caesarean section. Fourty nine Brazilian (Viçosa, Minas Gerais state) one-month-old infants were divided in two groups: full-term (n = 24) and pre-term (n = 25), and compared to each other. Each group was then characterised according to its mode of delivery. Infant stool samples were available for bifidobacterial characterisation by quantitative polymerase chain reaction (qPCR) method. All study infants were colonised by bifidobacteria. Bifidobacterium longum colonised all full-term and pre-term newborns. Differences were observed in counts of Bifidobacterium genus and Bifidobacterium longum between full-term and pre-term infants (8.8 log cells/g, IQR 7.9–9.1 vs. 7.1 log cells/g, IQR 6.6–8.6, p = 0.02 and 8.3 log cells/g, IQR 6.7–9.1 vs. 6.4 log cells/g, IQR 6.1–6.7, p = 0.001, respectively). Furthermore, the prevalence of Bifidobacterium lactis differed between pre-term caesarean and pre-term vaginally born infants (50.0% vs. 93.8%, p = 0.023). Gut bifidobacterial composition of one-month-old full-term infants differs from that of pre-term newborns in Viçosa, Minas Gerais state, Brazil. Gestational age is a factor influencing bacterial numbers and species, while mode of delivery have an impact on the prevalence and quantity of bifidobacteria in studied infants. Bifidobacteria may have an impact on later health of the infants and the species B . longum and B . lactis might provide clues on the potential probiotic applications in pre-term newborns at the risk of developing postnatal complications. [ABSTRACT FROM AUTHOR]