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6 results on '"Celik‐Turgut, Gurbet"'

3. In vivo examination of the effects of hydroxycinnamic acid on xenobiotic metabolizing and antioxidant enzymes

Author

Semiz Asli, Celik-Turgut Gurbet, Karakurt Serdar, Akca Hakan, Arslan Sevki, Adali Orhan, and Sen Alaattin

Subjects
hydroxycinnamic acids, drug-metabolizing enzymes, antioxidant enzymes, chemoprevention, Biology (General), QH301-705.5
Abstract

In the last decade, hydroxycinnamic acids (HCA) have gained increasing attention from researchers due to their antioxidant potential. The aim of this study was to examine in detail the impact of dietary HCA on particular types of P450 and also selected phase II and antioxidant enzymes in Wistar rat. HCA (10 mM/kg/day, i.p.) was administered for ten continuous days. Examination of the activities and mRNA and protein levels revealed that CYP2B, 2C6 and 3A enzyme activities were not altered significantly, with Western blot and qRT-PCR results corroborating this result. While treatment with HCA led to a significant reduction in CYP1A1/CYP1A2-associated enzyme activities, CYP1A1 protein, and mRNA levels were found to be unchanged. Aromatase (CYP19) activity, as well as protein and mRNA levels, were significantly reduced with HCA treatment. On the other hand, the NAD(P)H:quinone oxidoreductase 1 (NQO1), catalase (CAT), glutathione peroxidase (GPx) and glutathione S-transferases (GSTs) activities were increased significantly. Also, HCA treatment significantly increased the GST-mu and GST-theta mRNA levels. These observations may be of importance given the potential use of HCA as a chemopreventive and as an anticancer agent.

Published
2017
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5. Inhibitory Effect of Some Plant Essential Oils against Corn Stalk Rot and Ear Rot.

Author

CEYLAN, Yagmur, SAGLAN, Zehra, CELİK TURGUT, Gurbet, and ERDOGAN, Oktay

Subjects
VEGETABLE oils, ESSENTIAL oils, CORNSTALKS, CORN oil, BLACK cumin, GIBBERELLA fujikuroi, FUNGICIDES
Abstract

Copyright of Journal of the Faculty of Agriculture / Ziraat Fakültesi Dergisi is the property of Journal of the Faculty of Agriculture / Ziraat Fakültesi Dergisi and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2022
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6. LID - 10.1002/ardp.201700185 [doi]

Author

Yavuz, Serkan, Cetin, Aysu, Akdemir, ATİLLA, Doyduk, Dogukan, Disli, Ali, Celik Turgut, Gurbet, Sen, Alaattin, Yildirir, Yilmaz, and AKDEMİR, ATİLLA

Subjects
synthesis, protein p53, T-Lymphocytes, Apoptosis, multiple sclerosis, Raji cell line, T lymphocyte, 4 fluoro n [9 (4 hydroxy 5 (hydroxymethyl)tetrahydrofuran 2 yl) 9h purin 6 yl)benzamide, antineoplastic agent, comparative study, DNA strand breakage, B-Lymphocytes, computer aided design, drug effect, Cell Cycle, cell line, unclassified drug, Molecular Docking Simulation, priority journal, fluorescence, antiinflammatory agent, Yavuz S., Cetin A., Akdemir A., Doyduk D., Disli A., Celik Turgut G., Sen A., Yildirir Y., -Synthesis and Functional Investigations of Computer Designed Novel Cladribine-Like Compounds for the Treatment of Multiple Sclerosis-, ARCHIV DER PHARMAZIE, cilt.350, 2017, signal transduction, Immunosuppressive Agents, DNA repair, cladribine derivative, Antineoplastic Agents, cladribine, chemistry, Article, Multiple Sclerosis, Relapsing-Remitting, DNA fragmentation assay, drug mechanism, gene expression profiling, computer simulation, double stranded DNA break, Humans, human, structure activity relation, B lymphocyte, human cell, DNA Breaks, 2 amino 2 [4 (6 amino 9h purin 9 yl)butyl]propane 1,3 diol, molecular docking, immunosuppressive agent, CCRF-CEM cell line, Antineoplastic Agents/chemical synthesis/chemistry/pharmacology, Apoptosis/drug effects, B-Lymphocytes/drug effects/metabolism, Cell Cycle/drug effects, Cell Line, Cladribine/chemical synthesis/chemistry/*pharmacology, Computer Simulation, DNA Breaks/drug effects, DNA Damage/*drug effects, Immunosuppressive Agents/chemical synthesis/chemistry/*pharmacology, Multiple Sclerosis, Relapsing-Remitting/*drug therapy, T-Lymphocytes/drug effects/metabolism, CCRF-CEM cells, RAJI cells, DNA damage, drug synthesis, Molecular modeling studies, immunomodulating agent, metabolism, ATR protein
Abstract

Cladribine (2-CdA) is used as an anti-cancer drug but is currently studied as a potential treatment for use in relapsing-remitting multiple sclerosis (MS). In this study, we computer designed, synthesized, and characterized two novel derivatives of 2-CdA, K1-5d and K2-4c, and investigated their underlying mechanism of beneficial effect using the CCRF-CEM and RAJI cell lines. For this purpose, we first determined their effect on MS and DNA damage and repair-related gene expression profiles using custom arrays along with 2-CdA treatment at non-toxic doses. Then, we determined whether cells underwent apoptosis after treatment with 2-CdA, K1-5d, and K2-4c in CCRF-CEM and RAJI cells, using the DNA fragmentation assay. It was found that both derivatives modulated the expression of the pathway-related genes that are important in inflammatory signaling, apoptosis, ATM/ATR, double-strand break repair, and the cell cycle. Furthermore, 2-CdA, K1-5d, and K2-4c significantly activated apoptosis in both cell lines. In summary, our data demonstrate that although both derivatives act as anti-inflammatory and apoptotic agents, inducing the accumulation of DNA strand breaks and activating the ultimate tumor suppressor p53 in T and B lymphocytes, the K1-5d derivative has shown more promising activities for further studies. Türkiye Bilimsel Ve Teknolojik Araştırma Kurumu ( Tübitak )

Published
2017

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