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2. On the Assessment of Gray Code Kernels for Motion Characterization in People with Multiple Sclerosis: A Preliminary Study

Author

Moro, Matteo, Cellerino, Maria, Inglese, Matilde, Casadio, Maura, Odone, Francesca, Noceti, Nicoletta, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Tan, Kay Chen, Series Editor, Bellotti, Francesco, editor, Grammatikakis, Miltos D., editor, Mansour, Ali, editor, Ruo Roch, Massimo, editor, Seepold, Ralf, editor, Solanas, Agusti, editor, and Berta, Riccardo, editor

Published
2024
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3. Predicting disease severity in multiple sclerosis using multimodal data and machine learning

Author

Andorra, Magi, Freire, Ana, Zubizarreta, Irati, de Rosbo, Nicole Kerlero, Bos, Steffan D., Rinas, Melanie, Høgestøl, Einar A., de Rodez Benavent, Sigrid A., Berge, Tone, Brune-Ingebretse, Synne, Ivaldi, Federico, Cellerino, Maria, Pardini, Matteo, Vila, Gemma, Pulido-Valdeolivas, Irene, Martinez-Lapiscina, Elena H., Llufriu, Sara, Saiz, Albert, Blanco, Yolanda, Martinez-Heras, Eloy, Solana, Elisabeth, Bäcker-Koduah, Priscilla, Behrens, Janina, Kuchling, Joseph, Asseyer, Susanna, Scheel, Michael, Chien, Claudia, Zimmermann, Hanna, Motamedi, Seyedamirhosein, Kauer-Bonin, Josef, Brandt, Alex, Saez-Rodriguez, Julio, Alexopoulos, Leonidas G., Paul, Friedemann, Harbo, Hanne F., Shams, Hengameh, Oksenberg, Jorge, Uccelli, Antonio, Baeza-Yates, Ricardo, and Villoslada, Pablo

Published
2024
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4. Signs and symptoms of COVID‐19 in patients with multiple sclerosis

Author

Schiavetti, Irene, Carmisciano, Luca, Ponzano, Marta, Cordioli, Cinzia, Cocco, Eleonora, Marfia, Girolama Alessandra, Inglese, Matilde, Filippi, Massimo, Radaelli, Marta, Bergamaschi, Roberto, Immovilli, Paolo, Capobianco, Marco, De Rossi, Nicola, Brichetto, Giampaolo, Scandellari, Cinzia, Cavalla, Paola, Pesci, Ilaria, Confalonieri, Paolo, Perini, Paola, Trojano, Maria, Lanzillo, Roberta, Tedeschi, Gioacchino, Comi, Giancarlo, Battaglia, Mario Alberto, Patti, Francesco, Salvetti, Marco, Sormani, Maria Pia, Group, MuSC‐19 Study, Abbadessa, Gianmarco, Aguglia, Umberto, Allegorico, Lia, Allegri, Beatrice Maria Rossi, Alteno, Anastasia, Amato, Maria Pia, Annovazzi, Pietro, Antozzi, Carlo, Appendino, Lucia, Arena, Sebastiano, Baione, Viola, Balgera, Roberto, Barcella, Valeria, Baroncini, Damiano, Barrilà, Caterina, Bellacosa, Alessandra, Bellucci, Gianmarco, Bergamaschi, Valeria, Bezzini, Daiana, Biolzi, Beatrice, Bisecco, Alvino, Bonavita, Simona, Borriello, Giovanna, Bosa, Chiara, Bosco, Antonio, Bovis, Francesca, Bozzali, Marco, Brambilla, Laura, Morra, Vincenzo Brescia, Buccafusca, Maria, Bucciantini, Elisabetta, Bucello, Sebastiano, Buscarinu, Maria Chiara, Cabboi, Maria Paola, Calabrese, Massimiliano, Calabria, Francesca, Caleri, Francesca, Camilli, Federico, Caniatti, Luisa Maria, Cantello, Roberto, Capra, Ruggero, Capuano, Rocco, Carta, Patrizia, Celani, Maria Grazia, Cellerino, Maria, Cerqua, Raffaella, Chisari, Clara, Clerici, Raffaella, Clerico, Marinella, Cola, Gaia, Conte, Antonella, Conti, Marta Zaffira, Cordano, Christian, Cordera, Susanna, Corea, Francesco, Correale, Claudio, Cottone, Salvatore, Crescenzo, Francesco, Curti, Erica, d’Ambrosio, Alessandro, D’Amico, Emanuele, Danni, Maura Chiara, d’Arma, Alessia, Dattola, Vincenzo, de Biase, Stefano, De Luca, Giovanna, De Mercanti, Stefania Federica, De Mitri, Paolo, De Stefano, Nicola, Della Cava, Fabio Maria, Della Cava, Marco, and Di Lemme, Sonia

Subjects
Neurosciences, Multiple Sclerosis, Brain Disorders, Pain Research, Neurodegenerative, Good Health and Well Being, Humans, Aged, COVID-19, Ageusia, SARS-CoV-2, Anosmia, MuSC-19 Study Group, demyelinating diseases, disease-modifying treatment, multiple sclerosis, neurological disorders, Clinical Sciences, Neurology & Neurosurgery
Abstract

Background and purposeClinical outcomes of multiple sclerosis (MS) patients affected by coronavirus disease 2019 (COVID-19) have been thoroughly investigated, but a further analysis on main signs and symptoms and their risk factors still needs attention. The objective of this study was to group together and describe based on similarity the most common signs and symptoms of COVID-19 in MS patients and identify all factors associated with their manifestation.MethodLogistic and linear regression models were run to recognize factors associated with each pooled group of symptoms and their total number.ResultsFrom March 2020 to November 2021, data were collected from 1354 MS patients with confirmed infection of COVID-19. Ageusia and anosmia was less frequent in older people (odds ratio [OR] 0.98; p = 0.005) and more in smoker patients (OR 1.39; p = 0.049). Smoke was also associated with an incremental number of symptoms (OR 1.24; p = 0.031), substance abuse (drugs or alcohol), conjunctivitis and rash (OR 5.20; p = 0.042) and the presence of at least one comorbidity with shortness of breath, tachycardia or chest pain (OR 1.24; p = 0.008). Some disease-modifying therapies were associated with greater frequencies of certain COVID-19 symptoms (association between anti-CD20 therapies and increment in the number of concomitant symptoms: OR 1.29; p = 0.05). Differences in frequencies between the three waves were found for flu-like symptoms (G1, p = 0.024), joint or muscle pain (G2, p = 0.013) and ageusia and anosmia (G5, p

Published
2022

5. The effect of air pollution on COVID‐19 severity in a sample of patients with multiple sclerosis

Author

Bergamaschi, Roberto, Ponzano, Marta, Schiavetti, Irene, Carmisciano, Luca, Cordioli, Cinzia, Filippi, Massimo, Radaelli, Marta, Immovilli, Paolo, Capobianco, Marco, De Rossi, Nicola, Brichetto, Giampaolo, Cocco, Eleonora, Scandellari, Cinzia, Cavalla, Paola, Pesci, Ilaria, Zito, Antonio, Confalonieri, Paolo, Marfia, Girolama Alessandra, Perini, Paola, Inglese, Matilde, Trojano, Maria, Morra, Vincenzo Brescia, Pisoni, Enrico, Tedeschi, Gioacchino, Comi, Giancarlo, Battaglia, Mario Alberto, Patti, Francesco, Salvetti, Marco, Sormani, Maria Pia, Abbadessa, Gianmarco, Aguglia, Umberto, Allegorico, Lia, Allegri, Rossi Beatrice Maria, Alteno, Anastasia, Amato, Maria Pia, Annovazzi, Pietro, Antozzi, Carlo, Appendino, Lucia, Arena, Sebastiano, Baione, Viola, Balgera, Roberto, Barcella, Valeria, Baroncini, Damiano, Barrilà, Caterina, Battaglia, Mario A, Bellacosa, Alessandra, Bellucci, Gianmarco, Bergamaschi, Valeria, Bezzini, Daiana, Biolzi, Beatrice, Bisecco, Alvino, Bonavita, Simona, Borriello, Giovanna, Bosa, Chiara, Bosco, Antonio, Bovis, Francesca, Bozzali, Marco, Brambilla, Laura, Brescia, Morra Vincenzo, Buccafusca, Maria, Bucciantini, Elisabetta, Bucello, Sebastiano, Buscarinu, Maria Chiara, Cabboi, Maria Paola, Calabrese, Massimiliano, Calabria, Francesca, Caleri, Francesca, Camilli, Federico, Caniatti, Luisa Maria, Cantello, Roberto, Capra, Ruggero, Capuano, Rocco, Carta, Patrizia, Celani, Maria Grazia, Cellerino, Maria, Cerqua, Raffaella, Chisari, Clara, Clerici, Raffaella, Clerico, Marinella, Cola, Gaia, Conte, Antonella, Conti, Marta Zaffira, Cordano, Christian, Cordera, Susanna, Corea, Francesco, Correale, Claudio, Cottone, Salvatore, Crescenzo, Francesco, Curti, Erica, d'Ambrosio, Alessandro, and D'Amico, Emanuele

Subjects
Clinical Research, Neurosciences, Multiple Sclerosis, Brain Disorders, Autoimmune Disease, Neurodegenerative, Climate-Related Exposures and Conditions, Good Health and Well Being, Sustainable Cities and Communities, Air Pollution, COVID-19, Humans, Particulate Matter, SARS-CoV-2, MuSC-19 study group, air pollution, coronavirus, multiple sclerosis, Clinical Sciences, Neurology & Neurosurgery
Abstract

Background and purposeSome studies have shown that air pollution, often assessed by thin particulate matter with diameter below 2.5 µg/m3 (PM2.5), may contribute to severe COVID-19 courses, as well as play a role in the onset and evolution of multiple sclerosis (MS). However, the impact of air pollution on COVID-19 has never been explored specifically amongst patients with MS (PwMS). This retrospective observational study aims to explore associations between PM2.5 and COVID-19 severity amongst PwMS.MethodsData were retrieved from an Italian web-based platform (MuSC-19) which includes PwMS with COVID-19. PM2.5 2016-2018 average concentrations were provided by the Copernicus Atmospheric Monitoring Service. Italian patients inserted in the platform from 15 January 2020 to 9 April 2021 with a COVID-19 positive test were included. Ordered logistic regression models were used to study associations between PM2.5 and COVID-19 severity.ResultsIn all, 1087 patients, of whom 13% required hospitalization and 2% were admitted to an intensive care unit or died, were included. Based on the multivariate analysis, higher concentrations of PM2.5 increased the risk of worse COVID-19 course (odds ratio 1.90; p = 0.009).ConclusionsEven if several other factors explain the unfavourable course of COVID-19 in PwMS, the role of air pollutants must be considered and further investigated.

Published
2022

6. Erratum: Choroidal Thickness in Multiple Sclerosis: An Optical Coherence Tomography Study

Author

Masala, Alessandro, Mola, Ilaria Di, Cellerino, Maria, Pera, Valentina, Vagge, Aldo, Uccelli, Antonio, Cordano, Christian, Traverso, Carlo E, and Iester, Michele

Subjects
Biomedical and Clinical Sciences, Ophthalmology and Optometry, Neurosciences, Clinical sciences, Biological psychology
Abstract

This corrects the article on p. 334 in vol. 18, PMID: 35589321.

Published
2022

7. Choroidal Thickness in Multiple Sclerosis: An Optical Coherence Tomography Study

Author

Masala, Alessandro, Di Mola, Ilaria, Cellerino, Maria, Pera, Valentina, Vagge, Aldo, Uccelli, Antonio, Christian, Cordano, Traverso, Carlo E, and Iester, Michele

Subjects
Biomedical and Clinical Sciences, Ophthalmology and Optometry, Eye Disease and Disorders of Vision, Biomedical Imaging, Brain Disorders, Bioengineering, Autoimmune Disease, Neurodegenerative, Multiple Sclerosis, Clinical Research, Neurosciences, Detection, screening and diagnosis, 4.2 Evaluation of markers and technologies, Neurological, choroidal thickness, optical coherence tomography, multiple sclerosis, optic neuritis, Clinical sciences, Biological psychology
Abstract

Background and purposeTo identify changes in the choroidal thickness (CT) in multiple sclerosis (MS) patients with and without optic neuritis (ON) using enhanced-depth-imaging optical coherence tomography (EDI-OCT).MethodsThis cross-sectional study included 96 eyes with MS and 28 eyes of healthy controls. All participants underwent an ophthalmologic examination and EDI-OCT scanning (Spectralis, Heidelberg Engineering, Germany) to assess the CT and the retinal nerve fiber layer (RNFL) thickness. MS patients were divided into two groups: 1) with and 2) without a history of ON. The CT was evaluated in the fovea and at six horizontal and six vertical points at 500, 1,000, and 1,500 µm from the fovea. Paired t-tests were used to compare the groups, and p-value

Published
2022

8. Cognitive rehabilitation and aerobic exercise for cognitive impairment in people with progressive multiple sclerosis (CogEx): a randomised, blinded, sham-controlled trial

Author

Pietrusz, Alex, Tacchino, Andrea, Smith, Angela, Michelsen, Anne Sophie, Kristin, Ashlie, Bichler, Blake, Truax, Brendon, Vizzino, Carmen, Jones, Catherine Danielle, Holme, Catherine, Smith, Catherine, Keytsman, Charly, Pollio, Chiara, Cole, Chris, Niccolai, Claudia, Cordani, Claudio, Colombo, Eleonora, Pelosin, Elisa, Vanzeir, Ellen, Vannetti, Fedrica, Gerli, Filippo, Maranta, Francesco, Riccitelli, Gianna, Pasquini, Guido, Wilkinson, Holly, Mosca, Irene, Braisher, James, Baird, Jessica, Podda, Jessica, Morecraft, Jimmy, Lenaerts, Joke, Puopolo, Juliana, Algie, Kimberley, Kenton, Laura, Toll, Laura, Madsen, Laurits T., Knevels, Leen, Lee, Louie, Pedullà, Ludovico, Cellerino, Maria, Braisher, Marie, Jørgensen, Marie-Louise Kjeldgaard, Pardini, Matteo, Sibilia, Mauro, Nabarro, Max, Diedmann, Mette Dahl, DiBenedetto, Michael, Curran, Michele, Koch, Michelle, D'Hooge, Mieke, Moore, Nancy, Weerdt, Natasja De, Preziosa, Paolo, Pajak, Patrizia, Silic, Petra, Walters, Rebecca Bex, Finegan, Rebecca, Veldkamp, Renee, Hernandez, Roberto, Donnee, Rudi, Casagrande, Sabrina, Lancia, Samantha, Bella, Sara Della, Vandecasteele, Séline, Vandael, Veerle, Feinstein, Anthony, Amato, Maria Pia, Brichetto, Giampaolo, Chataway, Jeremy, Chiaravalloti, Nancy D, Cutter, Gary, Dalgas, Ulrik, DeLuca, John, Farrell, Rachel, Feys, Peter, Filippi, Massimo, Freeman, Jennifer, Inglese, Matilde, Meza, Cecilia, Motl, Robert W, Rocca, Maria A, Sandroff, Brian M, and Salter, Amber

Published
2023
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9. Relationship between retinal inner nuclear layer, age, and disease activity in progressive MS

Author

Cellerino, Maria, Cordano, Christian, Boffa, Giacomo, Bommarito, Giulia, Petracca, Maria, Sbragia, Elvira, Novi, Giovanni, Lapucci, Caterina, Capello, Elisabetta, Uccelli, Antonio, and Inglese, Matilde

Subjects
Biomedical and Clinical Sciences, Ophthalmology and Optometry, Neurosciences, Biomedical Imaging, Neurological, Adult, Aged, Aging, Cohort Studies, Disease Progression, Female, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Male, Middle Aged, Multiple Sclerosis, Retinal Ganglion Cells, Retinal Photoreceptor Cell Inner Segment, Retrospective Studies, Tomography, Optical Coherence, Young Adult
Abstract

To investigate whether inner nuclear layer (INL) thickness as assessed with optical coherence tomography differs between patients with progressive MS (P-MS) according to age and disease activity. In this retrospective longitudinal analysis, differences in terms of peripapillary retinal nerve fiber layer (pRNFL), ganglion cell layer + inner plexiform layer (GCIPL), INL and T1/T2 lesion volumes (T1LV/T2LV) were assessed between 84 patients with P-MS and 36 sex- and age-matched healthy controls (HCs) and between patients stratified according to age (cut-off: 51 years) and evidence of clinical/MRI activity in the previous 12 months RESULTS: pRNFL and GCIPL thickness were significantly lower in patients with P-MS than in HCs (p = 0.003 and p < 0.0001, respectively). INL was significantly thicker in patients aged < 51 years compared to the older ones and HCs (38.2 vs 36.5 and 36.7 μm; p = 0.038 and p = 0.04, respectively) and in those who presented MRI activity (new T2/gadolinium-enhancing lesions) in the previous 12 months compared to the ones who did not and HCs (39.5 vs 36.4 and 36.7 μm; p = 0.003 and p = 0.008, respectively). Recent MRI activity was significantly predicted by greater INL thickness (Nagelkerke R2 0.36, p = 0.001). INL thickness was higher in younger patients with P-MS with recent MRI activity, a criterion used in previous studies to identify a specific subset of patients with P-MS who best responded to disease-modifying treatment. If this finding is confirmed, we suggest that INL thickness might be a useful tool in stratification of patients with P-MS for current and experimental treatment choice.

Published
2019

10. Is It Time for Ocrelizumab Extended Interval Dosing in Relapsing Remitting MS? Evidence from An Italian Multicenter Experience During the COVID-19 Pandemic

Author

Zanghì, Aurora, Avolio, Carlo, Signoriello, Elisabetta, Abbadessa, Gianmarco, Cellerino, Maria, Ferraro, Diana, Messina, Christian, Barone, Stefania, Callari, Graziella, Tsantes, Elena, Sola, Patrizia, Valentino, Paola, Granella, Franco, Patti, Francesco, Lus, Giacomo, Bonavita, Simona, Inglese, Matilde, and D’Amico, Emanuele

Published
2022
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11. Brain disconnectome mapping derived from white matter lesions and serum neurofilament light levels in multiple sclerosis: A longitudinal multicenter study

Author

Rise, Henning H., Brune, Synne, Chien, Claudia, Berge, Tone, Bos, Steffan D., Andorrà, Magí, Valdeolivas, Irene Pulido, Beyer, Mona K., Sowa, Piotr, Scheel, Michael, Brandt, Alexander U., Asseyer, Susanna, Blennow, Kaj, Pedersen, Mads L., Zetterberg, Henrik, de Schotten, Michel Thiebaut, Cellerino, Maria, Uccelli, Antonio, Paul, Friedemann, Villoslada, Pablo, Harbo, Hanne F., Westlye, Lars T., and Høgestøl, Einar A.

Published
2022
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13. Safety, tolerability, and activity of mesenchymal stem cells versus placebo in multiple sclerosis (MESEMS): a phase 2, randomised, double-blind crossover trial

Author

Aghdami, Naser, Agüera-Morales, Eduardo, Ali, Rehiana, Allan, David, Arab, Leila, Battaglia, Mario, Berry, Isabelle, Blinkenberg, Morten, Bonetti, Bruno, Brundin, Lou, Capelli, Chiara, Castellan, Lucio, Cellerino, Maria, Cencioni, Maria Teresa, Clanet, Michel, Comi, Giancarlo, Courtman, David, Dazzi, Francesco, Fischer-Nielsen, Anne, Fernandez, Oscar, Fernandez, Victoria, Freedman, Mark S., Furlan, Roberto, Gimona, Mario, Gualandi, Francesca, Guan, Qingdong, Iacobaeus, Ellen, Inglese, Matilde, Introna, Martino, Izquierdo, Guillermo, Karimi, Shahedeh, Laroni, Alice, Le Blanc, Katarina, Loaiza, Sandra, Mallik, Shahrukh, Marley, Stephen, Marrie, Ruth Ann, Marriot, James, Martino, Gianvito, Nabavi, Seyed Massood, Miller, David, Muraro, Paolo A., Nicholas, Richard, Oliveri, Roberto S, Orengo, Giovanni, Palanicawande, Renuka, Pardini, Matteo, Radue, Ernst W, Ramo Tello, Cristina, Rush, Carolina, Schiavetti, Irene, Sellner, Johann, Sensebe, Luc, Soelberg Sorensen, Per, Sormani, Maria Pia, Strunk, Dirk, Szwajcer, David, Thalamas, Claire, Uccelli, Antonio, Wuerfel, Jens Thomas, Battaglia, Mario Alberto, Marriott, James, Muraro, Paolo, Radue, Ernst, Sorensen, Per Soelberg, and Freedman, Mark S

Published
2021
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16. Maternal and fetal outcomes in an Italian multicentric cohort of women with multiple sclerosis exposed to dimethyl fumarate during pregnancy.

Author

Landi, Doriana, Bartolomeo, Silvia, Bovis, Francesca, Amato, Maria Pia, Bonavita, Simona, Borriello, Giovanna, Buccafusca, Maria, Bucello, Sebastiano, Cavalla, Paola, Cellerino, Maria, Centonze, Diego, Cocco, Eleonora, Conte, Antonella, Cortese, Antonio, D'Amico, Emanuele, Di Filippo, Massimiliano, Docimo, Renato, Fantozzi, Roberta, Ferraro, Elisabetta, and Filippi, Massimo

Subjects
MULTIPLE pregnancy, PREGNANCY outcomes, DIMETHYL fumarate, MISCARRIAGE, MULTIPLE sclerosis
Abstract

Background: Evidence on the impact of dimethyl fumarate (DMF) during pregnancy in women with multiple sclerosis (MS) is limited. Objectives: To investigate disease activity and pregnancy outcomes in a retrospective cohort of women exposed to DMF in early pregnancy. Methods: Women discontinuing DMF after pregnancy confirmation were identified from 29 Italian MS Centers. Disease activity 12 months before conception, during pregnancy, and 12 months postpartum were recorded, exploring reactivation predictors. Pregnancy and fetal outcomes were assessed. Results: The study analyzed 137 pregnancies (12 pregnancy losses, 125 live births) from 137 women (mean age 32.9 ± 4.7 years), discontinuing DMF within a median (interquartile range (IQR)) interval of 4.9 (3.7–5.7) weeks from conception. In live birth pregnancies, annualized relapse rate (ARR) significantly decreased during pregnancy (ARR = 0.07, 95% confidence interval (CI): 0.03–0.14, p = 0.021) compared to pre-conception (ARR = 0.21 (95% CI: 0.14–0.30)) and increased postpartum ((ARR = 0.22 (95% CI: 0.15–0.32), p = 0.006). Median time to first relapse (TTFR) was 3.16 (IQR: 1:87–5.42) months. Higher pre-conception relapse number (hazard ratio (HR) = 2.33, 95% CI: 1.08–5.02) and Expanded Disability Status Scale (EDSS; HR = 1.81, 95% CI: 1.17-2.74) were associated with shorter TTFR, while treatment resumption with longer TTFR (HR = 0.29, 95% CI: 0.11–0.74). Fetal outcomes were unaffected by DMF exposure. Conclusion: DMF discontinuation does not increase relapse risk during pregnancy. Early therapy restart prevents postpartum relapses. Early DMF exposure shows no adverse fetal outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Pediatric optic neuritis and anti MOG antibodies: a cohort of Italian patients

Author

Giacomini, Thea, Foiadelli, Thomas, Annovazzi, Pietro, Nosadini, Margherita, Gastaldi, Matteo, Franciotta, Diego, Panarese, Claudio, Capris, Paolo, Camicione, Paola, Lanteri, Paola, De Grandis, Elisa, Prato, Giulia, Cordani, Ramona, Nobili, Lino, Morana, Giovanni, Rossi, Andrea, Pistorio, Angela, Cellerino, Maria, Uccelli, Antonio, Sartori, Stefano, Savasta, Salvatore, and Mancardi, Maria Margherita

Published
2020
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21. Influence of Previous Disease-Modifying Drug Exposure on T-Lymphocyte Dynamic in Patients With Multiple Sclerosis Treated With Ocrelizumab

Author

Landi, Doriana, Grimaldi, Alfonso, Bovis, Francesca, Ponzano, Marta, Fantozzi, Roberta, Buttari, Fabio, Signoriello, Elisabetta, Lus, Giacomo, Lucchini, Matteo, Mirabella, Massimiliano, Cellerino, Maria, Inglese, Matilde, Cola, Gaia, Nicoletti, Carolina Gabri, Mataluni, Giorgia, Centonze, Diego, and Marfia, Girolama Alessandra

Published
2022
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22. COVID-19 Severity in Multiple Sclerosis: Putting Data Into Context

Author

Sormani, Maria Pia, Schiavetti, Irene, Carmisciano, Luca, Cordioli, Cinzia, Filippi, Massimo, Radaelli, Marta, Immovilli, Paolo, Capobianco, Marco, De Rossi, Nicola, Brichetto, Giampaolo, Cocco, Eleonora, Scandellari, Cinzia, Cavalla, Paola, Pesci, Ilaria, Zito, Antonio, Confalonieri, Paolo, Marfia, Girolama Alessandra, Perini, Paola, Inglese, Matilde, Trojano, Maria, Brescia Morra, Vincenzo, Tedeschi, Gioacchino, Comi, Giancarlo, Battaglia, Mario Alberto, Patti, Francesco, Salvetti, Marco, Abbadessa, Gianmarco, Aguglia, Umberto, Allegorico, Lia, Allegri Rossi, Beatrice Maria, Amato, Maria Pia, Annovazzi, Pietro, Antozzi, Carlo, Appendino, Lucia, Arena, Sebastiano, Baione, Viola, Balgera, Roberto, Barcella, Valeria, Baroncini, Damiano, Barrilà, Caterina, Bellacosa, Alessandra, Bellucci, Gianmarco, Bergamaschi, Roberto, Bergamaschi, Valeria, Bezzini, Daiana, Biolzi, Beatrice, Bisecco, Alvino, Bonavita, Simona, Borriello, Giovanna, Bosa, Chiara, Bosco, Antonio, Bovis, Francesca, Bozzali, Marco, Brambilla, Laura, Buccafusca, Maria, Bucciantini, Elisabetta, Bucello, Sebastiano, Buscarinu, Maria Chiara, Cabboi, Maria Paola, Calabrese, Massimiliano, Calabria, Francesca, Caleri, Francesca, Camilli, Federico, Caniatti, Luisa Maria, Cantello, Roberto, Capra, Ruggero, Capuano, Rocco, Carta, Patrizia, Celani, Maria Grazia, Cellerino, Maria, Cerqua, Raffaella, Chisari, Clara, Clerici, Raffaella, Clerico, Marinella, Cola, Gaia, Conte, Antonella, Conti, Marta Zaffira, Cordano, Christian, Cordera, Susanna, Corea, Francesco, Correale, Claudio, Cottone, Salvatore, Crescenzo, Francesco, Curti, Erica, dʼAmbrosio, Alessandro, DʼAmico, Emanuele, Danni, Maura Chiara, dʼArma, Alessia, Dattola, Vincenzo, de Biase, Stefano, Luca, Giovanna De, Mercanti, Stefania Federica De, De Mitri, Paolo, De Stefano, Nicola, Cava, Marco Della, Napoli, Mario di, Sapio, Alessia Di, Docimo, Renato, Dutto, Anna, Evangelista, Luana, Fanara, Salvatore, Diana, Ferraro, Ferrò, Maria Teresa, Fioretti, Cristina, Fratta, Mario, Frau, Jessica, Fronza, Marzia, Furlan, Roberto, Gajofatto, Alberto, Gallo, Antonio, Gallo, Paolo, Gasperini, Claudio, Ghazaryan, Anna, Giometto, Bruno, Gobbin, Francesca, Govone, Flora, Granella, Franco, Grange, Erica, Grasso, Maria Grazia, Guareschi, Angelica, Guaschino, Clara, Guerrieri, Simone, Guidetti, Donata, Iaffaldano, Pietro, Ianniello, Antonio, Iasevoli, Luigi, Imperiale, Daniele, Infante, Maria Teresa, Iodice, Rosa, Iovino, Aniello, Konrad, Giovanna, Landi, Doriana, Lanzillo, Roberta, Lapucci, Caterina, Lavorgna, Luigi, LʼEpiscopo, Maria Rita, Leva, Serena, Liberatore, Giuseppe, Lo Re, Marianna, Longoni, Marco, Lopiano, Leonardo, Lorefice, Lorena, Lucchini, Matteo, Lus, Giacomo, Maimone, Davide, Malentacchi, Maria, Mallucci, Giulia, Malucchi, Simona, Mancinelli, Chiara Rosa, Mancinelli, Luca, Manganotti, Paolo, Maniscalco, Giorgia Teresa, Mantero, Vittorio, Marangoni, Sabrina, Marastoni, Damiano, Marinelli, Fabiana, Marti, Alessandro, Boneschi, Filippo Martinelli, Masserano Zoli, Federco, Matta, Francesca, Mendozzi, Laura, Meucci, Giuseppe, Miante, Silvia, Miele, Giuseppina, Milano, Eva, Mirabella, Massimiliano, Missione, Rosanna, Moccia, Marcello, Moiola, Lucia, Montepietra, Sara, MontiBragadin, Margherita, Montini, Federico, Motta, Roberta, Nardone, Raffaele, Nicoletti, Carolina Gabri, Nobile-Orazio, Eduardo, Nozzolillo, Agostino, Onofrj, Marco, Orlandi, Riccardo, Palmieri, Anna, Paolicelli, Damiano, Pasquali, Livia, Pastò, Luisa, Pedrazzoli, Elisabetta, Petracca, Maria, Petrone, Alfredo, Piantadosi, Carlo, Pietroboni, Anna M, Pinardi, Federica, Ponzano, Marta, Portaccio, Emilio, Pozzato, Mattia, Pozzilli, Carlo, Prosperini, Luca, Protti, Alessandra, Ragonese, Paolo, Rasia, Sarah, Realmuto, Sabrina, Repice, Anna, Rigoni, Eleonora, Rilla, Maria Teresa, Rinaldi, Francesca, Romano, Calogero Marcello, Ronzoni, Marco, Rovaris, Marco, Ruscica, Francesca, Sabattini, Loredana, Salemi, Giuseppe, Saraceno, Lorenzo, Sartori, Alessia, Sartori, Arianna, Sbragia, Elvira, Scarano, Giuditta Ilaria, Scarano, Valentina, Schillaci, Valentina, Sessa, Maria, Sgarito, Caterina, Sibilia, Grazia, Siciliano, Gabriele, Signori, Alessio, Signoriello, Elisabetta, Sinisi, Leonardo, Sireci, Francesca, Sola, Patrizia, Solaro, Claudio, Sotgiu, Stefano, Sparaco, Maddalena, Stromillo, Maria Laura, Strumia, Silvia, Susani, Emanuela Laura, Tabiadon, Giulietta, Teatini, Francesco, Tomassini, Valentina, Tonietti, Simone, Torri, Clerici Valentina, Tortorella, Carla, Toscano, Simona, Totaro, Rocco, Trotta, Maria, Turano, Gabriella, Ulivelli, Monica, Valentino, Manzo, Vaula, Giovanna, Vecchio, Domizia, Vercellino, Marco, Verrengia, Elena Pinuccia, Vianello, Marika, Virgilio, Eleonora, Vitetta, Francesca, Vollaro, Stefano, Zaffaroni, Mauro, Zampolini, Mauro, Zarbo, Ignazio Roberto, and Zuliani, Luigi

Published
2022
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23. Multiscale networks in multiple sclerosis

Author

Kennedy, Keith E., primary, Kerlero de Rosbo, Nicole, additional, Uccelli, Antonio, additional, Cellerino, Maria, additional, Ivaldi, Federico, additional, Contini, Paola, additional, De Palma, Raffaele, additional, Harbo, Hanne F., additional, Berge, Tone, additional, Bos, Steffan D., additional, Høgestøl, Einar A., additional, Brune-Ingebretsen, Synne, additional, de Rodez Benavent, Sigrid A., additional, Paul, Friedemann, additional, Brandt, Alexander U., additional, Bäcker-Koduah, Priscilla, additional, Behrens, Janina, additional, Kuchling, Joseph, additional, Asseyer, Susanna, additional, Scheel, Michael, additional, Chien, Claudia, additional, Zimmermann, Hanna, additional, Motamedi, Seyedamirhosein, additional, Kauer-Bonin, Josef, additional, Saez-Rodriguez, Julio, additional, Rinas, Melanie, additional, Alexopoulos, Leonidas G., additional, Andorra, Magi, additional, Llufriu, Sara, additional, Saiz, Albert, additional, Blanco, Yolanda, additional, Martinez-Heras, Eloy, additional, Solana, Elisabeth, additional, Pulido-Valdeolivas, Irene, additional, Martinez-Lapiscina, Elena H., additional, Garcia-Ojalvo, Jordi, additional, and Villoslada, Pablo, additional

Published
2024
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24. Lesion phenotyping based on magnetic susceptibility in pediatric multiple sclerosis.

Author

Boccia, Vincenzo Daniele, Boffa, Giacomo, Lapucci, Caterina, Costagli, Mauro, Bosisio, Luca, Mancardi, Maria Margherita, Inglese, Matilde, and Cellerino, Maria

Subjects
MAGNETIC resonance imaging, MAGNETIC susceptibility, PARAMAGNETIC resonance, DISEASE duration, WHITE matter (Nerve tissue)
Abstract

Background and purpose: Pediatric multiple sclerosis (MS) displays different pathological features compared to adult MS, which can be studied in vivo by assessing tissue magnetic susceptibility with 3T‐MRI. We aimed to assess different white matter lesions (WMLs) phenotypes in pediatric MS patients using quantitative susceptibility mapping (QSM) and susceptibility mapping weighted imaging (SMWI) over 12 months. Methods: Eleven pediatric MS patients [female: 63.6%; mean ± standard deviation (SD) age and disease duration: 16.3 ± 2.2 and 2.4 ± 1.5; median (range) Expanded Disability Status Scale (EDSS) 1 (0‐2)] underwent 3 Tesla‐MRI exams and EDSS assessments at baseline and after 1 year. QSM and SMWI were obtained using 3‐dimensional (3D)‐segmented echo‐planar‐imaging with submillimetric spatial resolution. WMLs were classified according to their QSM appearance and SMWI was used to identify QSM hyperintensities ascribable to veins. Total brain volumes at baseline and follow‐up were computed using high‐resolution 3D T1‐weighted images. Results: Mean ± SD paramagnetic rim lesions (PRLs) prevalence was 7.0% ± 9.0. Fifty‐four percent (6/11) of patients exhibited at least one PRL, with one patient exhibiting ≥ 4 PRLs. All patients showed QSM‐iso‐/hypo‐intense lesions, which represented a mean ± SD of 65.8% ± 22.7 of total WMLs. QSM‐hyperintense WMLs showed a positive correlation with total brain volume reduction at follow‐up (r = 0.705; p =.02). No lesion was classified as different between baseline and follow‐up. Conclusion: Chronic compartmentalized inflammation seems to occur early in pediatric MS patients with short disease duration. A high prevalence of iso‐/hypo‐intense lesions was found, which could account for the higher remyelination potential in pediatric MS. [ABSTRACT FROM AUTHOR]

Published
2024
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26. Predicting disease severity in multiple sclerosis using multimodal data and machine learning

Author

Andorra, Magi, primary, Freire, Ana, additional, Zubizarreta, Irati, additional, de Rosbo, Nicole Kerlero, additional, Bos, Steffan D., additional, Rinas, Melanie, additional, Høgestøl, Einar A., additional, de Rodez Benavent, Sigrid A., additional, Berge, Tone, additional, Brune-Ingebretse, Synne, additional, Ivaldi, Federico, additional, Cellerino, Maria, additional, Pardini, Matteo, additional, Vila, Gemma, additional, Pulido-Valdeolivas, Irene, additional, Martinez-Lapiscina, Elena H., additional, Llufriu, Sara, additional, Saiz, Albert, additional, Blanco, Yolanda, additional, Martinez-Heras, Eloy, additional, Solana, Elisabeth, additional, Bäcker-Koduah, Priscilla, additional, Behrens, Janina, additional, Kuchling, Joseph, additional, Asseyer, Susanna, additional, Scheel, Michael, additional, Chien, Claudia, additional, Zimmermann, Hanna, additional, Motamedi, Seyedamirhosein, additional, Kauer-Bonin, Josef, additional, Brandt, Alex, additional, Saez-Rodriguez, Julio, additional, Alexopoulos, Leonidas G., additional, Paul, Friedemann, additional, Harbo, Hanne F., additional, Shams, Hengameh, additional, Oksenberg, Jorge, additional, Uccelli, Antonio, additional, Baeza-Yates, Ricardo, additional, and Villoslada, Pablo, additional

Published
2023
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27. Cognitive rehabilitation and aerobic exercise for cognitive impairment in people with progressive multiple sclerosis (CogEx): a randomised, blinded, sham-controlled trial

Author

Feinstein, Anthony, primary, Amato, Maria Pia, additional, Brichetto, Giampaolo, additional, Chataway, Jeremy, additional, Chiaravalloti, Nancy D, additional, Cutter, Gary, additional, Dalgas, Ulrik, additional, DeLuca, John, additional, Farrell, Rachel, additional, Feys, Peter, additional, Filippi, Massimo, additional, Freeman, Jennifer, additional, Inglese, Matilde, additional, Meza, Cecilia, additional, Motl, Robert W, additional, Rocca, Maria A, additional, Sandroff, Brian M, additional, Salter, Amber, additional, Pietrusz, Alex, additional, Tacchino, Andrea, additional, Smith, Angela, additional, Michelsen, Anne Sophie, additional, Kristin, Ashlie, additional, Bichler, Blake, additional, Truax, Brendon, additional, Vizzino, Carmen, additional, Jones, Catherine Danielle, additional, Holme, Catherine, additional, Smith, Catherine, additional, Keytsman, Charly, additional, Pollio, Chiara, additional, Cole, Chris, additional, Niccolai, Claudia, additional, Cordani, Claudio, additional, Colombo, Eleonora, additional, Pelosin, Elisa, additional, Vanzeir, Ellen, additional, Vannetti, Fedrica, additional, Gerli, Filippo, additional, Maranta, Francesco, additional, Riccitelli, Gianna, additional, Pasquini, Guido, additional, Wilkinson, Holly, additional, Mosca, Irene, additional, Braisher, James, additional, Baird, Jessica, additional, Podda, Jessica, additional, Morecraft, Jimmy, additional, Lenaerts, Joke, additional, Puopolo, Juliana, additional, Algie, Kimberley, additional, Kenton, Laura, additional, Toll, Laura, additional, Madsen, Laurits T., additional, Knevels, Leen, additional, Lee, Louie, additional, Pedullà, Ludovico, additional, Cellerino, Maria, additional, Braisher, Marie, additional, Jørgensen, Marie-Louise Kjeldgaard, additional, Pardini, Matteo, additional, Sibilia, Mauro, additional, Nabarro, Max, additional, Diedmann, Mette Dahl, additional, DiBenedetto, Michael, additional, Curran, Michele, additional, Koch, Michelle, additional, D'Hooge, Mieke, additional, Moore, Nancy, additional, Weerdt, Natasja De, additional, Preziosa, Paolo, additional, Pajak, Patrizia, additional, Silic, Petra, additional, Walters, Rebecca Bex, additional, Finegan, Rebecca, additional, Veldkamp, Renee, additional, Hernandez, Roberto, additional, Donnee, Rudi, additional, Casagrande, Sabrina, additional, Lancia, Samantha, additional, Bella, Sara Della, additional, Vandecasteele, Séline, additional, and Vandael, Veerle, additional

Published
2023
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29. Impact of COVID-19 on pregnancy and fetal outcomes in women with multiple sclerosis.

Author

Aprea, Maria Grazia, Schiavetti, Irene, Portaccio, Emilio, Ballerini, Chiara, Bonavita, Simona, Buscarinu, Maria, Calabrese, Massimiliano, Cavalla, Paola, Cellerino, Maria, Cordioli, Cinzia, Dattola, Vincenzo, De Biase, Stefano, De Meo, Ermelinda, Fantozzi, Roberta, Gallo, Antonio, Iasevoli, Luigi, Karabudak, Rana, Landi, Doriana, Lorefice, Lorena, and Moiola, Lucia

Subjects
PREGNANCY outcomes, COVID-19 pandemic, PREGNANT women, MULTIPLE sclerosis, PREGNANCY complications
Abstract

Background: In the general population, maternal COVID-19 is associated with worse maternal and fetal outcomes. Two previous studies have assessed COVID-19 clinical outcomes in pregnant women with multiple sclerosis (MS), but there are no data about maternal and fetal outcomes. Objectives: In this multicenter study, we aimed to assess maternal and fetal outcomes in pregnant women with MS and COVID-19 infection. Methods: We recruited pregnant patients with MS who contracted COVID-19 and were followed up in Italian and Turkish Centers, during 2020–2022. A control group was extracted from a previous Italian cohort. Associations between group (COVID-19 or healthy patients) and clinical outcomes (maternal complications, fetal malformations, and spontaneous abortion) were investigated with a weighted logistic regression where propensity score–based inverse probability of treatment weighting (IPTW) approach was applied for adjusting for difference in baseline confounders. Results: In the multivariable analysis, COVID-19 during pregnancy was associated with a higher risk of maternal complications (odd ratio (OR) = 2.12; 95% confidence interval (CI) = 1.32–3.48; p = 0.002), while it was not associated with higher risk of spontaneous abortion and fetal malformations. Conclusion: Our data indicate that COVID-19 during pregnancy increases the risk of maternal complications, while it seems to have no significant impact on fetal outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
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30. Impact of treatment on cellular immunophenotype in MS: A cross-sectional study

Author

Cellerino, Maria, Ivaldi, Federico, Pardini, Matteo, Rotta, Gianluca, Vila, Gemma, Bäcker-Koduah, Priscilla, Berge, Tone, Laroni, Alice, Lapucci, Caterina, Novi, Giovanni, Boffa, Giacomo, Sbragia, Elvira, Palmeri, Serena, Asseyer, Susanna, Høgestøl, Einar, Campi, Cristina, Piana, Michele, Inglese, Matilde, Paul, Friedemann, Harbo, Hanne F., Villoslada, Pablo, Kerlero de Rosbo, Nicole, and Uccelli, Antonio

Published
2020
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32. Tissue factor as a potential coagulative/vascular marker in relapsing-remitting multiple sclerosis

Author

Koudriavtseva, Tatiana, primary, Lorenzano, Svetlana, additional, Cellerino, Maria, additional, Truglio, Mauro, additional, Fiorelli, Marco, additional, Lapucci, Caterina, additional, D’Agosto, Giovanna, additional, Conti, Laura, additional, Stefanile, Annunziata, additional, Zannino, Silvana, additional, Filippi, Maria Maddalena, additional, Cortese, Antonio, additional, Piantadosi, Carlo, additional, Maschio, Marta, additional, Maialetti, Andrea, additional, Galiè, Edvina, additional, Salvetti, Marco, additional, and Inglese, Matilde, additional

Published
2023
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33. Clinical and radiological correlates of apathy in multiple sclerosis.

Author

Tazza, Francesco, Schiavi, Simona, Leveraro, Elisa, Cellerino, Maria, Boffa, Giacomo, Ballerini, Stefania, Dighero, Mara, Uccelli, Antonio, Sbragia, Elvira, Aluan, Kenda, Inglese, Matilde, and Lapucci, Caterina

Subjects
APATHY, MAGNETIC resonance imaging, MULTIPLE sclerosis, DIFFUSION tensor imaging, NEUROLOGICAL disorders, FRONTAL lobe
Abstract

Background: Although apathy has been associated with fronto-striatal dysfunction in several neurological disorders, its clinical and magnetic resonance imaging (MRI) correlates have been poorly investigated in people with multiple sclerosis (PwMS). Objectives: To evaluate clinical variables and investigate microstructural integrity of fronto-striatal grey matter (GM) and white matter (WM) structures using diffusion tensor imaging (DTI). Methods: A total of 123 PwMS (age: 40.25 ± 11.5; female: 60.9%; relapsing–remitting multiple sclerosis: 75.6%) were prospectively enrolled and underwent neurological and neuropsychological evaluation, including Expanded Disability Status Scale (EDSS), Apathy Evaluation Scale (AES-S), Hospital Anxiety and Depression Scale (HADS), Modified Fatigue Impact Scale (MFIS) and brain 3T-MRI volumes of whole brain, frontal/prefrontal cortex (PFC) and subcortical regions were calculated. DTI-derived metrics were evaluated in the same GM regions and in connecting WM tracts. Results: Apathetic PwMS (32.5%) showed lower education levels, higher HADS, MFIS scores and WM lesions volume than nonapathetic PwMS. Significant differences in DTI metrics were found in middle frontal, anterior cingulate and superior frontal PFC subregions and in caudate nuclei. Significant alterations were found in the right cingulum and left striatal-frontorbital tracts. Conclusions: Apathy in PwMS is associated with higher levels of physical disability, depression, anxiety and fatigue together with lower educational backgrounds. Microstructural damage within frontal cortex, caudate and fronto-striatal WM bundles is a significant pathological substrate of apathy in multiple sclerosis (MS). [ABSTRACT FROM AUTHOR]

Published
2024
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34. In-vivo characterization of macro- and microstructural injury of the subventricular zone in relapsing-remitting and progressive multiple sclerosis

Author

Cellerino, Maria, primary, Schiavi, Simona, additional, Lapucci, Caterina, additional, Sbragia, Elvira, additional, Boffa, Giacomo, additional, Rolla-Bigliani, Claudia, additional, Tonelli, Serena, additional, Boccia, Daniele, additional, Bruschi, Nicolò, additional, Tazza, Francesco, additional, Franciotta, Diego, additional, and Inglese, Matilde, additional

Published
2023
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35. Central vein sign and diffusion MRI differentiate microstructural features within white matter lesions of multiple sclerosis patients with comorbidities

Author

Lapucci, Caterina, primary, Tazza, Francesco, additional, Rebella, Silvia, additional, Boffa, Giacomo, additional, Sbragia, Elvira, additional, Bruschi, Nicolò, additional, Mancuso, Elisabetta, additional, Mavilio, Nicola, additional, Signori, Alessio, additional, Roccatagliata, Luca, additional, Cellerino, Maria, additional, Schiavi, Simona, additional, and Inglese, Matilde, additional

Published
2023
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36. Multiscale networks in multiple sclerosis

Author

Kennedy, Keith E, primary, Kerlero de Rosbo, Nicole, additional, Uccelli, Antonio, additional, Cellerino, Maria, additional, Ivaldi, Federico, additional, Contini, Paola, additional, De Palma, Raffaele, additional, Harbo, Hanne H, additional, Berge, Tone, additional, Bos, Steffan D, additional, Høgestøl, Einar A, additional, Brune-Ingebretsen, Synne, additional, de Rodez Benavent, Sigrid, additional, Paul, Friedemann, additional, Brandt, Alexander U, additional, Bäcker-Koduah, Priscilla, additional, Behrens, Janina, additional, Kuchling, Joseph, additional, Asseyer, Susana E, additional, Scheel, Michael, additional, Chien, Claudia, additional, Zimmermann, Hanna, additional, Motamedi, Seyedamirhosein, additional, Kauer-Bonin, Josef, additional, Saez-Rodriguez, Julio, additional, Rinas, Melani, additional, Alexopoulos, Leonidas, additional, Andorra, Magi, additional, Llufriu, Sara, additional, Saiz, Albert, additional, Blanco, Yolanda, additional, Martinez-Heras, Eloy, additional, Solana, Elisabeth, additional, Pulido-Valdeolivas, Irene, additional, Martinez-Lapiscina, Elena H, additional, Garcia-Ojalvo, Jordi, additional, and Villoslada, Pablo, additional

Published
2023
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37. CD19+ B cell values predict the increase of anti-SARS CoV2 antibodies in fingolimod-treated and COVID-19-vaccinated patients with multiple sclerosis

Author

Schiavetti, Irene, primary, Barcellini, Lucrezia, additional, Lapucci, Caterina, additional, Tazza, Francesco, additional, Cellerino, Maria, additional, Capello, Elisabetta, additional, Franciotta, Diego, additional, Inglese, Matilde, additional, Sormani, Maria Pia, additional, Uccelli, Antonio, additional, and Laroni, Alice, additional

Published
2023
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39. Exposure to natalizumab throughout pregnancy: effectiveness and safety in an Italian cohort of women with multiple sclerosis

Author

Landi, Doriana, primary, Bovis, Francesca, additional, Grimaldi, Alfonso, additional, Annovazzi, Pietro Osvaldo, additional, Bertolotto, Antonio, additional, Bianchi, Alessia, additional, Borriello, Giovanna, additional, Brescia Morra, Vincenzo, additional, Bucello, Sebastiano, additional, Buscarinu, Maria Chiara, additional, Caleri, Francesca, additional, Capobianco, Marco, additional, Capra, Ruggero, additional, Cellerino, Maria, additional, Centonze, Diego, additional, Cerqua, Raffaella, additional, Chisari, Clara Grazia, additional, Clerico, Marinella, additional, Cocco, Eleonora, additional, Cola, Gaia, additional, Cordioli, Cinzia, additional, Curti, Erica, additional, d'Ambrosio, Alessandro, additional, D'Amico, Emanuele, additional, De Luca, Giovanna, additional, Di Filippo, Massimiliano, additional, Di Lemme, Sonia, additional, Fantozzi, Roberta, additional, Ferraro, Diana, additional, Ferraro, Elisabetta, additional, Gallo, Antonio, additional, Gasperini, Claudio, additional, Granella, Franco, additional, Inglese, Matilde, additional, Lanzillo, Roberta, additional, Lorefice, Lorena, additional, Lus, Giacomo, additional, Malucchi, Simona, additional, Margoni, Monica, additional, Mataluni, Giorgia, additional, Mirabella, Massimiliano, additional, Moiola, Lucia, additional, Nicoletti, Carolina Gabri, additional, Nociti, Viviana, additional, Patti, Francesco, additional, Pinardi, Federica, additional, Portaccio, Emilio, additional, Pozzilli, Carlo, additional, Ragonese, Paolo, additional, Rasia, Sarah, additional, Salemi, Giuseppe, additional, Signoriello, Elisabetta, additional, Vitetta, Francesca, additional, Totaro, Rocco, additional, Sormani, Maria Pia, additional, Amato, Maria Pia, additional, and Marfia, Girolama Alessandra, additional

Published
2022
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41. Elevated risk of thrombotic manifestations of SARS-CoV-2 infection in cancer patients: A literature review

Author

Stefanile, Annunziata, Cellerino, Maria, and Koudriavtseva, Tatiana

Subjects
SARS-CoV-2, thrombotic manifestations, COVID-19, cancer, coagulation
Abstract

Coronavirus disease 2019 (COVID-19) results in higher risks of hospitalization or death in older patients and those with multiple comorbidities, including malignancies. Patients with cancer have greater risks of COVID-19 onset and worse prognosis. This excess is mainly explained by thrombotic complications. Indeed, an imbalance in the equilibrium between clot formation and bleeding, increased activation of coagulation, and endothelial dysfunction characterize both COVID-19 patients and those with cancer. With this review, we provide a summary of the pathological mechanisms of coagulation and thrombotic manifestations in these patients and discuss the possible therapeutic implications of these phenomena., EXCLI Journal; 21:Doc906; ISSN 1611-2156

Published
2022

42. Exposure to natalizumab throughout pregnancy: effectiveness and safety in an Italian cohort of women with multiple sclerosis

Author

Landi, Doriana, Bovis, Francesca, Grimaldi, Alfonso, Annovazzi, Pietro Osvaldo, Bertolotto, Antonio, Bianchi, Alessia, Borriello, Giovanna, Brescia Morra, Vincenzo, Bucello, Sebastiano, Buscarinu, Maria Chiara, Caleri, Francesca, Capobianco, Marco, Capra, Ruggero, Cellerino, Maria, Centonze, Diego, Cerqua, Raffaella, Chisari, Clara Grazia, Clerico, Marinella, Cocco, Eleonora, Cola, Gaia, Cordioli, Cinzia, Curti, Erica, D'Ambrosio, Alessandro, D'Amico, Emanuele, De Luca, Giovanna, Di Filippo, Massimiliano, Di Lemme, Sonia, Fantozzi, Roberta, Ferraro, Diana, Ferraro, Elisabetta, Gallo, Antonio, Gasperini, Claudio, Granella, Franco, Inglese, Matilde, Lanzillo, Roberta, Lorefice, Lorena, Lus, Giacomo, Malucchi, Simona, Margoni, Monica, Mataluni, Giorgia, Mirabella, Massimiliano, Moiola, Lucia, Nicoletti, Carolina Gabri, Nociti, Viviana, Patti, Francesco, Pinardi, Federica, Portaccio, Emilio, Pozzilli, Carlo, Ragonese, Paolo, Rasia, Sarah, Salemi, Giuseppe, Signoriello, Elisabetta, Vitetta, Francesca, Totaro, Rocco, Sormani, Maria Pia, Amato, Maria Pia, Marfia, Girolama Alessandra, Mirabella, Massimiliano (ORCID:0000-0002-7783-114X), Nociti, Viviana (ORCID:0000-0002-4607-3948), Landi, Doriana, Bovis, Francesca, Grimaldi, Alfonso, Annovazzi, Pietro Osvaldo, Bertolotto, Antonio, Bianchi, Alessia, Borriello, Giovanna, Brescia Morra, Vincenzo, Bucello, Sebastiano, Buscarinu, Maria Chiara, Caleri, Francesca, Capobianco, Marco, Capra, Ruggero, Cellerino, Maria, Centonze, Diego, Cerqua, Raffaella, Chisari, Clara Grazia, Clerico, Marinella, Cocco, Eleonora, Cola, Gaia, Cordioli, Cinzia, Curti, Erica, D'Ambrosio, Alessandro, D'Amico, Emanuele, De Luca, Giovanna, Di Filippo, Massimiliano, Di Lemme, Sonia, Fantozzi, Roberta, Ferraro, Diana, Ferraro, Elisabetta, Gallo, Antonio, Gasperini, Claudio, Granella, Franco, Inglese, Matilde, Lanzillo, Roberta, Lorefice, Lorena, Lus, Giacomo, Malucchi, Simona, Margoni, Monica, Mataluni, Giorgia, Mirabella, Massimiliano, Moiola, Lucia, Nicoletti, Carolina Gabri, Nociti, Viviana, Patti, Francesco, Pinardi, Federica, Portaccio, Emilio, Pozzilli, Carlo, Ragonese, Paolo, Rasia, Sarah, Salemi, Giuseppe, Signoriello, Elisabetta, Vitetta, Francesca, Totaro, Rocco, Sormani, Maria Pia, Amato, Maria Pia, Marfia, Girolama Alessandra, Mirabella, Massimiliano (ORCID:0000-0002-7783-114X), and Nociti, Viviana (ORCID:0000-0002-4607-3948)

Abstract

Assessing the risk of clinical and radiological reactivation during pregnancy and post partum in women with multiple sclerosis (MS) treated with natalizumab (NTZ) throughout pregnancy (LONG_EXP) compared with women interrupting treatment before (NO_EXP) and within >-30 days and ≤90 days from conception (SHORT_EXP), and describing newborns' outcomes.

Published
2022

44. Central Vein Sign and advanced diffusion MRI to differentiate demyelinating from comorbidities-related white matter lesions in patients with multiple sclerosis (P1-1.Virtual)

Author

Lapucci, Caterina, primary, Tazza, Francesco, additional, Rebella, Silvia, additional, Roccatagliata, Luca, additional, Mavilio, Ncola, additional, Boffa, Giacomo, additional, Sbragia, Elvira, additional, Bruschi, Nicolo, additional, Mancuso, Elisabetta, additional, Cellerino, Maria, additional, Schiavi, Simona, additional, and Inglese, Matilde, additional

Published
2022
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46. Evaluating the central vein sign in paediatric-onset multiple sclerosis: A case series study.

Author

Boccia, Vincenzo Daniele, Lapucci, Caterina, Cellerino, Maria, Tazza, Francesco, Rossi, Andrea, Schiavi, Simona, Mancardi, Maria Margherita, and Inglese, Matilde

Subjects
MULTIPLE sclerosis, VEINS
Abstract

The central vein sign (CVS) has been proposed as a biomarker of multiple sclerosis (MS). In adult-onset MS (AOMS), 40%-threshold of CVS positive (+) lesions demonstrated high accuracy for MS diagnosis. However, CVS+ lesions' performance has not been characterized in paediatric-onset (POMS) yet. We compared the CVS contribution to MS diagnosis in 10 POMS and 12 disease-duration-matched AOMS patients. Three POMS patients did not meet the 40%-threshold, while all AOMS patients were correctly diagnosed as having MS. The high proportion of periventricular confluent lesions, excluded from the CVS assessment, seemed to impair CVS sensitivity in POMS diagnosis. [ABSTRACT FROM AUTHOR]

Published
2023
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47. Safety, tolerability, and activity of mesenchymal stem cells versus placebo in multiple sclerosis (MESEMS): a phase 2, randomised, double-blind crossover trial

Author

Uccelli, Antonio, primary, Laroni, Alice, additional, Ali, Rehiana, additional, Battaglia, Mario Alberto, additional, Blinkenberg, Morten, additional, Brundin, Lou, additional, Clanet, Michel, additional, Fernandez, Oscar, additional, Marriott, James, additional, Muraro, Paolo, additional, Nabavi, Seyed Massood, additional, Oliveri, Roberto S, additional, Radue, Ernst, additional, Ramo Tello, Cristina, additional, Schiavetti, Irene, additional, Sellner, Johann, additional, Sorensen, Per Soelberg, additional, Sormani, Maria Pia, additional, Wuerfel, Jens Thomas, additional, Freedman, Mark S, additional, Aghdami, Naser, additional, Agüera-Morales, Eduardo, additional, Allan, David, additional, Arab, Leila, additional, Battaglia, Mario, additional, Berry, Isabelle, additional, Bonetti, Bruno, additional, Capelli, Chiara, additional, Castellan, Lucio, additional, Cellerino, Maria, additional, Cencioni, Maria Teresa, additional, Comi, Giancarlo, additional, Courtman, David, additional, Dazzi, Francesco, additional, Fischer-Nielsen, Anne, additional, Fernandez, Victoria, additional, Freedman, Mark S., additional, Furlan, Roberto, additional, Gimona, Mario, additional, Gualandi, Francesca, additional, Guan, Qingdong, additional, Iacobaeus, Ellen, additional, Inglese, Matilde, additional, Introna, Martino, additional, Izquierdo, Guillermo, additional, Karimi, Shahedeh, additional, Le Blanc, Katarina, additional, Loaiza, Sandra, additional, Mallik, Shahrukh, additional, Marley, Stephen, additional, Marrie, Ruth Ann, additional, Marriot, James, additional, Martino, Gianvito, additional, Miller, David, additional, Muraro, Paolo A., additional, Nicholas, Richard, additional, Orengo, Giovanni, additional, Palanicawande, Renuka, additional, Pardini, Matteo, additional, Radue, Ernst W, additional, Rush, Carolina, additional, Sensebe, Luc, additional, Soelberg Sorensen, Per, additional, Strunk, Dirk, additional, Szwajcer, David, additional, Thalamas, Claire, additional, and Uccelli, Antonio, additional

Published
2021
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48. Predictors of ocrelizumab effectiveness in patients with multiple sclerosis

Author

Cellerino, Maria, primary, Boffa, Giacomo, additional, Lapucci, Caterina, additional, Tazza, Francesco, additional, Sbragia, Elvira, additional, Mancuso, Elisabetta, additional, Bruschi, Nicolo, additional, Minguzzi, Simona, additional, Ivaldi, Federico, additional, Poire, Ilaria, additional, Laroni, Alice, additional, Mancardi, Gian Luigi, additional, Capello, Elisabetta, additional, Uccelli, Antonio, additional, Novi, Giovanni, additional, and Inglese, Matilde, additional

Published
2021
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50. SARS-CoV-2 serology after COVID-19 in multiple sclerosis: An international cohort study

Author

Sormani, Maria Pia, primary, Schiavetti, Irene, additional, Landi, Doriana, additional, Carmisciano, Luca, additional, De Rossi, Nicola, additional, Cordioli, Cinzia, additional, Moiola, Lucia, additional, Radaelli, Marta, additional, Immovilli, Paolo, additional, Capobianco, Marco, additional, Brescia Morra, Vincenzo, additional, Trojano, Maria, additional, Tedeschi, Gioacchino, additional, Comi, Giancarlo, additional, Battaglia, Mario Alberto, additional, Patti, Francesco, additional, Fragoso, Yara Dadalti, additional, Sen, Sedat, additional, Siva, Aksel, additional, Furlan, Roberto, additional, Salvetti, Marco, additional, Abbadessa, Gianmarco, additional, Aguglia, Umberto, additional, Allegorico, Lia, additional, Allegri, Rossi Beatrice Maria, additional, Amato, Maria Pia, additional, Annovazzi, Pietro, additional, Antozzi, Carlo, additional, Appendino, Lucia, additional, Arena, Sebastiano, additional, Baione, Viola, additional, Balgera, Roberto, additional, Barcella, Valeria, additional, Baroncini, Damiano, additional, Barrilà, Caterina, additional, Battaglia, Mario A., additional, Bellacosa, Alessandra, additional, Bellucci, Gianmarco, additional, Bergamaschi, Roberto, additional, Bergamaschi, Valeria, additional, Bezzini, Daiana, additional, Biolzi, Beatrice, additional, Bisecco, Alvino, additional, Bonavita, Simona, additional, Borriello, Giovanna, additional, Bosa, Chiara, additional, Bosco, Antonio, additional, Bovis, Francesca, additional, Bozzali, Marco, additional, Brambilla, Laura, additional, Brescia, Morra Vincenzo, additional, Brichetto, Giampaolo, additional, Buccafusca, Maria, additional, Bucciantini, Elisabetta, additional, Bucello, Sebastiano, additional, Buscarinu, Maria Chiara, additional, Cabboi, Maria Paola, additional, Calabrese, Massimiliano, additional, Calabria, Francesca, additional, Caleri, Francesca, additional, Camilli, Federico, additional, Caniatti, Luisa Maria, additional, Cantello, Roberto, additional, Capra, Ruggero, additional, Capuano, Rocco, additional, Carta, Patrizia, additional, Cavalla, Paola, additional, Celani, Maria Grazia, additional, Cellerino, Maria, additional, Cerqua, Raffaella, additional, Chisari, Clara, additional, Clerici, Raffaella, additional, Clerico, Marinella, additional, Cocco, Eleonora, additional, Cola, Gaia, additional, Confalonieri, Paolo, additional, Conte, Antonella, additional, Conti, Marta Zaffira, additional, Cordano, Christian, additional, Cordera, Susanna, additional, Corea, Francesco, additional, Correale, Claudio, additional, Cottone, Salvatore, additional, Crescenzo, Francesco, additional, Curti, Erica, additional, d’Ambrosio, Alessandro, additional, D’Amico, Emanuele, additional, Danni, Maura Chiara, additional, d’Arma, Alessia, additional, Dattola, Vincenzo, additional, de Biase, Stefano, additional, De Luca, Giovanna, additional, De Mercanti, Stefania Federica, additional, De Mitri, Paolo, additional, De Stefano, Nicola, additional, Della Cava, Marco, additional, di Napoli, Mario, additional, Di Sapio, Alessia, additional, Docimo, Renato, additional, Dutto, Anna, additional, Evangelista, Luana, additional, Fanara, Salvatore, additional, Ferraro, Diana, additional, Ferrò, Maria Teresa, additional, Filippi, Massimo, additional, Fioretti, Cristina, additional, Fratta, Mario, additional, Frau, Jessica, additional, Fronza, Marzia, additional, Gajofatto, Alberto, additional, Gallo, Antonio, additional, Gallo, Paolo, additional, Gasperini, Claudio, additional, Ghazaryan, Anna, additional, Giometto, Bruno, additional, Gobbin, Francesca, additional, Govone, Flora, additional, Granella, Franco, additional, Grange, Erica, additional, Grasso, Maria Grazia, additional, Guareschi, Angelica, additional, Guaschino, Clara, additional, Guerrieri, Simone, additional, Guidetti, Donata, additional, Iaffaldano, Pietro, additional, Ianniello, Antonio, additional, Iasevoli, Luigi, additional, Imperiale, Daniele, additional, Infante, Maria Teresa, additional, Inglese, Matilde, additional, Iodice, Rosa, additional, Iovino, Aniello, additional, Konrad, Giovanna, additional, Lanzillo, Roberta, additional, Lapucci, Caterina, additional, Lavorgna, Luigi, additional, L’Episcopo Maria, Rita, additional, Leva, Serena, additional, Liberatore, Giuseppe, additional, Lo Re, Marianna, additional, Longoni, Marco, additional, Lopiano, Leonardo, additional, Lorefice, Lorena, additional, Lucchini, Matteo, additional, Lus, Giacomo, additional, Maimone, Davide, additional, Malentacchi, Maria, additional, Mallucci, Giulia, additional, Malucchi, Simona, additional, Mancinelli, Chiara Rosa, additional, Mancinelli, Luca, additional, Manganotti, Paolo, additional, Maniscalco, Teresa Giorgia, additional, Mantero, Vittorio, additional, Marangoni, Sabrina, additional, Marastoni, Damiano, additional, Marfia, Alessandra Girolama, additional, Marinelli, Fabiana, additional, Marti, Alessandro, additional, Martinelli Boneschi, Filippo, additional, Masserano Zoli, Federco, additional, Matta, Francesca, additional, Mendozzi, Laura, additional, Meucci, Giuseppe, additional, Miante, Silvia, additional, Miele, Giuseppina, additional, Milano, Eva, additional, Mirabella, Massimiliano, additional, Missione, Rosanna, additional, Moccia, Marcello, additional, Montepietra, Sara, additional, Monti Bragadin, Margherita, additional, Montini, Federico, additional, Motta, Roberta, additional, Nardone, Raffaele, additional, Nicoletti, Carolina Gabri, additional, Nobile-Orazio, Eduardo, additional, Nozzolillo, Agostino, additional, Onofrj, Marco, additional, Orlandi, Riccardo, additional, Palmieri, Anna, additional, Paolicelli, Damiano, additional, Pasquali, Livia, additional, Pastò, Luisa, additional, Pedrazzoli, Elisabetta, additional, Perini, Paola, additional, Pesci, Ilaria, additional, Petracca, Maria, additional, Petrone, Alfredo, additional, Piantadosi, Carlo, additional, Pietroboni, Anna M., additional, Pinardi, Federica, additional, Ponzano, Marta, additional, Portaccio, Emilio, additional, Pozzato, Mattia, additional, Pozzilli, Carlo, additional, Prosperini, Luca, additional, Protti, Alessandra, additional, Ragonese, Paolo, additional, Rasia, Sarah, additional, Realmuto, Sabrina, additional, Repice, Anna, additional, Rigoni, Eleonora, additional, Rilla, Maria Teresa, additional, Rinaldi, Francesca, additional, Romano, Calogero Marcello, additional, Ronzoni, Marco, additional, Rovaris, Marco, additional, Ruscica, Francesca, additional, Sabattini, Loredana, additional, Salemi, Giuseppe, additional, Saraceno, Lorenzo, additional, Sartori, Alessia, additional, Sartori, Arianna, additional, Sbragia, Elvira, additional, Scandellari, Cinzia, additional, Scarano Giuditta, Ilaria, additional, Scarano, Valentina, additional, Schillaci, Valentina, additional, Sessa, Maria, additional, Sgarito, Caterina, additional, Sibilia, Grazia, additional, Siciliano, Gabriele, additional, Signori, Alessio, additional, Signoriello, Elisabetta, additional, Sinisi, Leonardo, additional, Sireci, Francesca, additional, Sola, Patrizia, additional, Solaro, Claudio, additional, Sormani, Maria Pia, additional, Sotgiu, Stefano, additional, Sparaco, Maddalena, additional, Stromillo, Maria Laura, additional, Strumia, Silvia, additional, Susani, Laura Emanuela, additional, Tabiadon, Giulietta, additional, Teatini, Francesco, additional, Tomassini, Valentina, additional, Tonietti, Simone, additional, Torri, Clerici Valentina, additional, Tortorella, Carla, additional, Toscano, Simona, additional, Totaro, Rocco, additional, Trotta, Maria, additional, Turano, Gabriella, additional, Ulivelli, Monica, additional, Valentino, Manzo, additional, Vaula, Giovanna, additional, Vecchio, Domizia, additional, Vercellino, Marco, additional, Verrengia, Elena Pinuccia, additional, Vianello, Marika, additional, Virgilio, Eleonora, additional, Vitetta, Francesca, additional, Vollaro, Stefano, additional, Zaffaroni, Mauro, additional, Zampolini, Mauro, additional, Zarbo, Ignazio Roberto, additional, Zito, Antonio, additional, and Zuliani, Luigi, additional

Published
2021
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