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330 results on '"Celsa, Ciro"'

1. Impact of metformin, statin, aspirin and insulin on the prognosis of uHCC patients receiving first line Lenvatinib or Atezolizumab plus Bevacizumab

Author

Rimini, Margherita, Montes, Margarida, Amadeo, Elisabeth, Vitiello, Francesco, Kudo, Masatoshi, Tada, Toshifumi, Suda, Goki, Shimose, Shigeo, Lonardi, Sara, Finkelmeier, Fabian, Salani, Francesca, Antonuzzo, Lorenzo, Marra, Fabio, Iavarone, Massimo, Cabibbo, Giuseppe, Foschi, Francesco Giuseppe, Silletta, Marianna, Sacco, Rodolfo, Rapposelli, Ilario Giovanni, Scartozzi, Mario, Nicoletta, Pella, Aldrighetti, Luca, Persano, Mara, Camera, Silvia, Rossari, Federico, Foti, Silvia, Kumada, Takashi, Hiraoka, Atsushi, Iwamoto, Hideki, Rizzato, Mario Domenico, Himmelsbach, Vera, Masi, Gianluca, Corradi, Mattia, Celsa, Ciro, Fabio, Conti, Frassineti, Giovanni Luca, Cascinu, Stefano, Casadei-Gardini, Andrea, and Presa, Jose

Published
2024
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3. Characteristics and outcomes of immunotherapy-related liver injury in patients with hepatocellular carcinoma versus other advanced solid tumours

Author

Celsa, Ciro, Cabibbo, Giuseppe, Fulgenzi, Claudia A.M., Scheiner, Bernhard, D’Alessio, Antonio, Manfredi, Giulia F., Nishida, Naoshi, Ang, Celina, Marron, Thomas U., Saeed, Anwaar, Wietharn, Brooke, Pinter, Matthias, Cheon, Jaekyung, Huang, Yi-Hsiang, Lee, Pei-Chang, Phen, Samuel, Gampa, Anuhya, Pillai, Anjana, Vivaldi, Caterina, Salani, Francesca, Masi, Gianluca, Roehlen, Natascha, Thimme, Robert, Vogel, Arndt, Schönlein, Martin, von Felden, Johann, Schulze, Kornelius, Wege, Henning, Galle, Peter R., Kudo, Masatoshi, Rimassa, Lorenza, Singal, Amit G., El Tomb, Paul, Ulahannan, Susanna, Parisi, Alessandro, Chon, Hong Jae, Hsu, Wei-Fan, Stefanini, Bernardo, Verzoni, Elena, Giusti, Raffaele, Veccia, Antonello, Catino, Annamaria, Aprile, Giuseppe, Guglielmini, Pamela Francesca, Di Napoli, Marilena, Ermacora, Paola, Antonuzzo, Lorenzo, Rossi, Ernesto, Verderame, Francesco, Zustovich, Fable, Ficorella, Corrado, Di Pietro, Francesca Romana, Battelli, Nicola, Negrini, Giorgia, Grossi, Francesco, Bordonaro, Roberto, Pipitone, Stefania, Banzi, Maria, Ricciardi, Serena, Laera, Letizia, Russo, Antonio, De Giorgi, Ugo, Cavanna, Luigi, Sorarù, Mariella, Montesarchio, Vincenzo, Bordi, Paola, Brunetti, Leonardo, Pinto, Carmine, Bersanelli, Melissa, Cammà, Calogero, Cortellini, Alessio, and Pinato, David J.

Published
2024
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4. Textbook Outcome After Trans-arterial Chemoembolization for Hepatocellular Carcinoma

Author

Mosconi, Cristina, O’Rourke, Joanne, Kloeckner, Roman, Sturm, Lukas, Golfieri, Rita, Celsa, Ciro, Fateen, Waleed, Odisio, Bruno C., Garanzini, Enrico Matteo, Peck-Radosavljevic, Markus, Borghi, Alberto, Ma, Yuk Ting, Stoehr, Fabian, Bettinger, Dominik, Giuffrida, Paolo, Aithal, Guruprasad P., Lin, Yuan-Mao, Spreafico, Carlo, Giampalma, Emanuela, Johnson, Philip, and Cucchetti, Alessandro

Published
2023
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5. Landscape of alcohol-related hepatocellular carcinoma in the last 15 years highlights the need to expand surveillance programs

Author

Biselli, Maurizio, Caraceni, Paolo, Gramenzi, Annagiulia, Benevento, Francesca, Granito, Alessandro, Muratori, Luca, Piscaglia, Fabio, Tovoli, Francesco, Allegrini, Gloria, Cammà, Calogero, Cabibbo, Giuseppe, Giacchetto, Carmelo Marco, Giuffrida, Paolo, Grassini, Maria Vittoria, Grova, Mauro, Rancatore, Gabriele, Stornello, Caterina, Adotti, Valentina, Cavoli, Tancredi Li, Marra, Fabio, Rosi, Martina, Bevilacqua, Vittoria, Borghi, Alberto, Napoli, Lucia, Conti, Fabio, Frassineti, G.L., Migliano, Maria Teresa, de Matthaeis, Nicoletta, Ponziani, Francesca Romana, Missale, Gabriele, Olivani, Andrea, Capasso, Mario, Cossiga, Valentina, Guarino, Maria, Marina Cela, Ester, Facciorusso, Antonio, Graziosi, Camilla, Lauria, Valentina, Pelecca, Giorgio, Schirripa, Marta, Chegai, Fabrizio, Raso, Armando, Bozzi, Alessio, Franzè, Maria Stella, Saitta, Carlo, Sauchella, Assunta, Dajti, Elton, Ravaioli, Federico, Plaz Torres, Maria Corina, Pieri, Giulia, Oliveri, Filippo, Ricco, Gabriele, Romagnoli, Veronica, Inno, Alessandro, Marchetti, Fabiana, Coccoli, Pietro, Malerba, Antonio, Cappelli, Alberta, Golfieri, Rita, Mosconi, Cristina, Renzulli, Matteo, Reggidori, Nicola, Bucci, Laura, Santi, Valentina, Stefanini, Benedetta, Lani, Lorenzo, Rampoldi, Davide, Ghittoni, Giorgia, Farinati, Fabio, Masotto, Alberto, Stefanini, Bernardo, Mega, Andrea, Biasini, Elisabetta, Foschi, Francesco Giuseppe, Svegliati-Baroni, Gianluca, Sangiovanni, Angelo, Campani, Claudia, Raimondo, Giovanni, Vidili, Gianpaolo, Gasbarrini, Antonio, Celsa, Ciro, Di Marco, Mariella, Giannini, Edoardo G., Sacco, Rodolfo, Brunetto, Maurizia Rossana, Azzaroli, Francesco, Magalotti, Donatella, Morisco, Filomena, Rapaccini, Gian Ludovico, Nardone, Gerardo, Vitale, Alessandro, and Trevisani, Franco

Published
2023
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6. Personalised management of patients with hepatocellular carcinoma: a multiparametric therapeutic hierarchy concept

Author

Baccarani, Umberto, Brancaccio, Giuseppina, Cozzolongo, Raffaele, Cucchetti, Alessandro, De Matthaeis, Nicoletta, Di Sandro, Stefano, Famularo, Simone, Finotti, Michele, Foschi, Francesco G, Ghinolfi, Davide, Guarracino, Marco, Gruttadauria, Salvatore, Guarino, Maria, Kostandini, Alba, Lenci, Ilaria, Levi Sandri, Giovanni B, Manzia, Tommaso M, Marasco, Giovanni, Masarone, Mario, Mazzarelli, Chiara, Melandro, Fabio, Miele, Luca, Morisco, Filomena, Nicolini, Daniele, Pagano, Duilio, Pelizzaro, Filippo, Pieri, Giulia, Piscaglia, Fabio, Plaz Torres, Maria Corina, Pravisani, Riccardo, Rendina, Maria, Romano, Fabrizio, Russo, Francesco P, Sacco, Rodolfo, Sangiovanni, Angelo, Sposito, Carlo, Tortora, Raffaella, Tovoli, Francesco, Viganò, Mauro, Violi, Paola, Vitale, Alessandro, Cabibbo, Giuseppe, Iavarone, Massimo, Viganò, Luca, Pinato, David J, Ponziani, Francesca Romana, Lai, Quirino, Casadei-Gardini, Andrea, Celsa, Ciro, Galati, Giovanni, Gambato, Martina, Crocetti, Laura, Renzulli, Matteo, Giannini, Edoardo G, Farinati, Fabio, Trevisani, Franco, and Cillo, Umberto

Published
2023
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8. Supplementary Table S9 from Safety and Preliminary Efficacy of Pembrolizumab Following Transarterial Chemoembolization for Hepatocellular Carcinoma: The PETAL Phase Ib Study

Author

Pinato, David J., primary, D'Alessio, Antonio, primary, Fulgenzi, Claudia Angela Maria, primary, Schlaak, Alexandra Emilia, primary, Celsa, Ciro, primary, Killmer, Saskia, primary, Blanco, Jesus Miguens, primary, Ward, Caroline, primary, Stikas, Charalampos-Vlasios, primary, Openshaw, Mark R., primary, Acuti, Nicole, primary, Nteliopoulos, Georgios, primary, Balcells, Cristina, primary, Keun, Hector C., primary, Goldin, Robert D., primary, Ross, Paul J., primary, Cortellini, Alessio, primary, Thomas, Robert, primary, Young, Anna-Mary, primary, Danckert, Nathan, primary, Tait, Paul, primary, Marchesi, Julian R., primary, Bengsch, Bertram, primary, and Sharma, Rohini, primary

Published
2024
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9. SAT-113 Long-term therapy with intravenous human albumin increase survival in patients with decompensated cirrhosis and refractory ascites

Author

Lombardo, Antonino, primary, Capodicasa, Luigi, additional, Alaimo, Domenico, additional, Mercurio, Francesco, additional, Zimbardo, Angelo, additional, Simone, Fabio, additional, Alessi, Nicola, additional, Celsa, Ciro, additional, Pennisi, Grazia, additional, Cabibbo, Giuseppe, additional, Petta, Salvatore, additional, Camma, Calogero, additional, Calvaruso, Vincenza, additional, and Di Marco, Vito, additional

Published
2024
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10. THU-464 aMAP score predicts progression-free survival in patients receiving atezolizumab plus bevacizumab for hepatocellular carcinoma

Author

Vithayathil, Mathew, primary, D'Alessio, Antonio, additional, Fulgenzi, Claudia, additional, Celsa, Ciro, additional, Manfredi, Giulia, additional, Nishida, Naoshi, additional, Schoenlein, Martin, additional, von Felden, Johann, additional, Schulze, Kornelius, additional, Wege, Henning, additional, Saeed, Anwaar, additional, Wietharn, Brooke, additional, Hildebrand, Hannah, additional, Wu, Linda, additional, Ang, Celina, additional, Marron, Thomas U., additional, Weinmann, Arndt, additional, Galle, Peter R., additional, Bettinger, Dominik, additional, Lin, Chun-yen, additional, Vogel, Arndt, additional, Scheiner, Bernhard, additional, Lee, Pei-Chang, additional, Huang, Yi-Hsiang, additional, Amara, Suneetha, additional, Muzaffar, Mahvish, additional, Naqash, Abdul Rafeh, additional, Zanuso, Valentina, additional, Pressiani, Tiziana, additional, Cabibbo, Giuseppe, additional, Dalbeni, Andrea, additional, Pinter, Matthias, additional, Singal, Amit, additional, Chon, Hong Jae, additional, Cortellini, Alessio, additional, Kudo, Masatoshi, additional, Rimassa, Lorenza, additional, Pinato, David J., additional, and Sharma, Rohini, additional

Published
2024
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11. FRI-317 Clinical outcomes of metabolic liver disease versus non-alcoholic fatty liver disease: a meta-analysis of observational studies

Author

Pennisi, Grazia, primary, Infantino, Giuseppe, additional, Celsa, Ciro, additional, Maria, Gabriele Di, additional, Enea, Marco, additional, Vaccaro, Marco, additional, Cannella, Roberto, additional, Ciccioli, Carlo, additional, La Mantia, Claudia, additional, Mantovani, Alessandro, additional, Mercurio, Francesco, additional, Tilg, Herbert, additional, Targher, Giovanni, additional, Marco, Vito Di, additional, Camma, Calogero, additional, and Petta, Salvatore, additional

Published
2024
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12. THU-101 Non-invasive tests for ruling out high-risk esophageal varices in patients with primary biliary cholangitis based on the cholestasis degree

Author

Calvaruso, Vincenza, primary, Celsa, Ciro, additional, Cristoferi, Laura, additional, Scaravaglio, Miki, additional, Nofit, Eugenia, additional, Smith, Rachel, additional, Kaur, Senamjit, additional, Di Maria, Gabriele, additional, Capodicasa, Luigi, additional, Cadamuro, Luca, additional, Gerussi, Alessio, additional, Malinverno, Federica, additional, Lampertico, Pietro, additional, Cazzagon, Nora, additional, Marzioni, Marco, additional, Vespasiani-Gentilucci, Umberto, additional, Colapietro, Francesca, additional, Andreone, Pietro, additional, Lleo, Ana, additional, Rigamonti, Cristina, additional, Viganò, Mauro, additional, Giannini, Edoardo, additional, Russello, Maurizio, additional, Vanni, Ester, additional, Cerini, Federica, additional, Orlandini, Alessandra, additional, Brunetto, Maurizia, additional, Niro, Grazia Anna, additional, Vettori, Giovanni, additional, Castellaneta, Antonino, additional, Cardinale, Vincenzo, additional, Alvaro, Domenico, additional, Mega, Andrea, additional, Palitti, Valeria Pace, additional, Bellanti, Francesco, additional, Marco, Vito Di, additional, Mells, George, additional, Culver, Emma, additional, Invernizzi, Pietro, additional, Camma, Calogero, additional, and Carbone, Marco, additional

Published
2024
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13. THU-471-YI From randomised clinical trials to clinical practice: a systematic reviewand meta-analysis of real-word data on atezolizumab plus bevacizumab for advanced hepatocellular carcinoma

Author

Manfredi, Giulia Francesca, primary, Fulgenzi, Claudia, additional, Celsa, Ciro, additional, Stefanini, Bernardo, additional, D'Alessio, Antonio, additional, Pinter, Matthias, additional, Scheiner, Bernhard, additional, Awosika, Nichola, additional, Huang, Yi-Hsiang, additional, Lin, Chun-yen, additional, Dalbeni, Andrea, additional, Vogel, Arndt, additional, Galle, Peter R., additional, Kudo, Masatoshi, additional, Rimassa, Lorenza, additional, Chon, Hong Jae, additional, Cabibbo, Giuseppe, additional, Piscaglia, Fabio, additional, Camma, Calogero, additional, Pillai, Anjana, additional, Pirisi, Mario, additional, Singal, Amit, additional, and Pinato, David J., additional

Published
2024
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14. SAT-209-YI A Markov model unveiling the impact of Resmetirom on the natural history of MASLD patients with baseline significant or severe liver fibrosis

Author

Pennisi, Grazia, primary, Di Maria, Gabriele, additional, Enea, Marco, additional, Vaccaro, Marco, additional, Ciccioli, Carlo, additional, Celsa, Ciro, additional, Infantino, Giuseppe, additional, Tulone, Adele, additional, Di Marco, Vito, additional, Camma, Calogero, additional, and Petta, Salvatore, additional

Published
2024
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15. Characteristics and survival of patients with primary biliary cholangitis and hepatocellular carcinoma

Author

Biselli, Maurizio, Caraceni, Paolo, Gramenzi, Annagiulia, Benevento, Francesca, Granito, Alessandro, Muratori, Luca, Piscaglia, Fabio, Bertellini, Federica, Farinati, Fabio, Palano, Giorgio, Pelizzaro, Filippo, Penzo, Barbara, Pinto, Elisa, Allegrini, Gloria, Cammà, Calogero, Celsa, Ciro, Giuffrida, Paolo, Stornello, Caterina, Grova, Mauro, Giacchetto, Carmelo Marco, Rancatore, Gabriele, Grassini, Maria Vittoria, Adotti, Valentina, Gitto, Stefano, Marra, Fabio, Rosi, Martina, Bevilacqua, Vittoria, Borghi, Alberto, Gardini, Andrea Casadei, Conti, Fabio, Napoli, Lucia, Domenicali, Marco, Migliano, Maria Teresa, de Matthaeis, Nicoletta, Ponziani, Francesca Romana, Olivani, Andrea, Missale, Gabriele, Cossiga, Valentina, Capasso, Mario, Morisco, Filomena, Cela, Ester Marina, Facciorusso, Antonio, Lauria, Valentina, Ghittoni, Giorgia, Pelecca, Giorgio, Chegai, Fabrizio, Coratella, Fabio, Ortenzi, Mariano, Dell'Isola, Serena, Franzè, Maria Stella, Saitta, Carlo, Sauchella, Assunta, Dajti, Elton, Ravaioli, Federico, Oliveri, Filippo, Ricco, Gabriele, Romagnoli, Veronica, Inno, Alessandro, Marchetti, Fabiana, Coccoli, Pietro, Malerba, Antonio, Cappelli, Alberta, Golfieri, Rita, Mosconi, Cristina, Renzulli, Matteo, Giannini, Edoardo G., Pieri, Giulia, Labanca, Sara, Plaz Torres, Maria Corina, Gasbarrini, Antonio, Biasini, Elisabetta, Campani, Claudia, Cazzagon, Nora, Foschi, Francesco Giuseppe, Mega, Andrea, Masotto, Alberto, Raimondo, Giovanni, Rapaccini, Gian Ludovico, Sacco, Rodolfo, Caturelli, Eugenio, Guarino, Maria, Tovoli, Francesco, Vidili, Gianpaolo, Brunetto, Maurizia Rossana, Nardone, Gerardo, Svegliati-Baroni, Gianluca, Magalotti, Donatella, Azzaroli, Francesco, Cabibbo, Giuseppe, Di Marco, Maria, Sangiovanni, Angelo, and Trevisani, Franco

Published
2022
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16. Immunotherapy vs Best Supportive Care for Patients With Hepatocellular Cancer With Child-Pugh B Dysfunction.

Author

Fulgenzi, Claudia Angela Maria, Scheiner, Bernhard, D'Alessio, Antonio, Mehan, Aman, Manfredi, Giulia F., Celsa, Ciro, Nishida, Naoshi, Ang, Celina, Marron, Thomas U., Wu, Linda, Saeed, Anwaar, Wietharn, Brooke, Cammarota, Antonella, Pressiani, Tiziana, Pinter, Matthias, Sharma, Rohini, Cheon, Jaekyung, Huang, Yi-Hsiang, Lee, Pei-Chang, and Phen, Samuel

Published
2024
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20. Comparison of prognostic models in advanced hepatocellular carcinoma patients undergoing Sorafenib: A multicenter study.

Author

Marasco, Giovanni, Colecchia, Antonio, Bacchi Reggiani, Maria Letizia, Celsa, Ciro, Farinati, Fabio, Giannini, Edoardo Giovanni, Benevento, Francesca, Rapaccini, Gian Ludovico, Caturelli, Eugenio, Di Marco, Mariella, Biasini, Elisabetta, Marra, Fabio, Morisco, Filomena, Foschi, Francesco Giuseppe, Zoli, Marco, Gasbarrini, Antonio, Baroni, Gianluca Svegliati, Masotto, Alberto, Sacco, Rodolfo, Raimondo, Giovanni, Azzaroli, Francesco, Mega, Andrea, Vidili, Gianpaolo, Brunetto, Maurizia Rossana, Nardone, Gerardo, Dajti, Elton, Ravaioli, Federico, Avanzato, Francesca, Festi, Davide, and Trevisani, Franco

Published
2021
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21. Dynamic angiopoietin-2 assessment predicts survival and chronic course in hospitalized patients with COVID-19

Author

Villa, Erica, Critelli, Rosina, Lasagni, Simone, Melegari, Alessandra, Curatolo, Angela, Celsa, Ciro, Romagnoli, Dante, Melegari, Gabriele, Pivetti, Alessandra, Di Marco, Lorenza, Casari, Federico, Arioli, Dimitriy, Turrini, Fabrizio, Zuccaro, Valentina, Cassaniti, Irene, Riefolo, Mattia, de Santis, Elena, Bernabucci, Veronica, Bianchini, Marcello, Lei, Barbara, De Maria, Nicola, Carulli, Lucia, Schepis, Filippo, Gozzi, Chiara, Malaguti, Silvio, Del Buono, Mariagrazia, Brugioni, Lucio, Torricelli, Pietro, Trenti, Tommaso, Pinelli, Giovanni, Bertellini, Elisabetta, Bruno, Raffaele, Cammà, Calogero, and d'Errico, Antonia

Published
2021
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22. Non-Invasive Diagnostic Tests for Portal Hypertension in Patients with HBV- and HCV-Related Cirrhosis: A Comprehensive Review.

Author

Celsa, Ciro, Veneziano, Marzia, Di Giorgio, Francesca Maria, Cannova, Simona, Lombardo, Antonino, Errigo, Emanuele, Landro, Giuseppe, Simone, Fabio, Sinagra, Emanuele, and Calvaruso, Vincenza

Subjects
NONINVASIVE diagnostic tests, PORTAL hypertension, PATIENT portals, HYPERTENSION, PLATELET count
Abstract

Clinically significant portal hypertension (CSPH) in patients with compensated advanced chronic liver disease indicates an increased risk of decompensation and death. While invasive methods like hepatic venous–portal gradient measurement is considered the gold standard, non-invasive tests (NITs) have emerged as valuable tools for diagnosing and monitoring CSPH. This review comprehensively explores non-invasive diagnostic modalities for portal hypertension, focusing on NITs in the setting of hepatitis B and hepatitis C virus-related cirrhosis. Biochemical-based NITs can be represented by single serum biomarkers (e.g., platelet count) or by composite scores that combine different serum biomarkers with each other or with demographic characteristics (e.g., FIB-4). On the other hand, liver stiffness measurement and spleen stiffness measurement can be assessed using a variety of elastography techniques, and they can be used alone, in combination with, or as a second step after biochemical-based NITs. The incorporation of liver and spleen stiffness measurements, alone or combined with platelet count, into established and validated criteria, such as Baveno VI or Baveno VII criteria, provides useful tools for the prediction of CSPH and for ruling out high-risk varices, potentially avoiding invasive tests like upper endoscopy. Moreover, they have also been shown to be able to predict liver-related events (e.g., the occurrence of hepatic decompensation). When transient elastography is not available or not feasible, biochemical-based NITs (e.g., RESIST criteria, that are based on the combination of platelet count and albumin levels) are valid alternatives for predicting high-risk varices both in patients with untreated viral aetiology and after sustained virological response. Ongoing research should explore novel biomarkers and novel elastography techniques, but current evidence supports the utility of routine blood tests, LSM, and SSM as effective surrogates in diagnosing and staging portal hypertension and predicting patient outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
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25. Initial uptake of durvalumab with or without tremelimumab for advanced hepatocellular carcinoma in routine clinical practice: Preliminary results of the international DT-real study.

Author

Celsa, Ciro, primary, Nishida, Naoshi, additional, Arvind, Ashwini, additional, Ulahannan, Susanna Varkey, additional, Li, Michael, additional, Scheiner, Bernhard, additional, Fulgenzi, Claudia A.M., additional, D'Alessio, Antonio, additional, Manfredi, Giulia F, additional, Stefanini, Bernardo, additional, Cabibbo, Giuseppe, additional, Cortellini, Alessio, additional, Pinter, Matthias, additional, Kelley, Robin Kate, additional, El Tomb, Paul Antoine, additional, Singal, Amit G., additional, Kudo, Masatoshi, additional, and Pinato, David James, additional

Published
2024
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26. Mechanisms of Resistance to Immunotherapy in Hepatocellular Carcinoma

Author

Manfredi, Giulia Francesca, primary, Celsa, Ciro, additional, John, Chloe, additional, Jones, Charlotte, additional, Acuti, Nicole, additional, Scheiner, Bernhard, additional, Fulgenzi, Claudia Angela Maria, additional, Korolewicz, James, additional, Pinter, Matthias, additional, Gennari, Alessandra, additional, Mauri, Francesco, additional, Pirisi, Mario, additional, Minisini, Rosalba, additional, Vincenzi, Federica, additional, Burlone, Michela, additional, Rigamonti, Cristina, additional, Donadon, Matteo, additional, Cabibbo, Giuseppe, additional, D'Alessio, Antonio, additional, and Pinato, David James, additional

Published
2023
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27. Competing-risk analysis of coronavirus disease 2019 in-hospital mortality in a Northern Italian centre from SMAtteo COvid19 REgistry (SMACORE)

Author

Zuccaro, Valentina, Celsa, Ciro, Sambo, Margherita, Battaglia, Salvatore, Sacchi, Paolo, Biscarini, Simona, Valsecchi, Pietro, Pieri, Teresa Chiara, Gallazzi, Ilaria, Colaneri, Marta, Sachs, Michele, Roda, Silvia, Asperges, Erika, Lupi, Matteo, Di Filippo, Alessandro, Seminari, Elena, Di Matteo, Angela, Novati, Stefano, Maiocchi, Laura, Enea, Marco, Attanasio, Massimo, Cammà, Calogero, and Bruno, Raffaele

Published
2021
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28. Direct-acting antivirals after successful treatment of early hepatocellular carcinoma improve survival in HCV-cirrhotic patients

Author

Cabibbo, Giuseppe, Celsa, Ciro, Calvaruso, Vincenza, Petta, Salvatore, Cacciola, Irene, Cannavò, Maria Rita, Madonia, Salvatore, Rossi, Margherita, Magro, Bianca, Rini, Francesca, Distefano, Marco, Larocca, Licia, Prestileo, Tullio, Malizia, Giuseppe, Bertino, Gaetano, Benanti, Francesco, Licata, Anna, Scalisi, Ignazio, Mazzola, Giovanni, Di Rosolini, Maria Antonietta, Alaimo, Giuseppe, Averna, Alfonso, Cartabellotta, Fabio, Alessi, Nicola, Guastella, Salvatore, Russello, Maurizio, Scifo, Gaetano, Squadrito, Giovanni, Raimondo, Giovanni, Trevisani, Franco, Craxì, Antonio, Di Marco, Vito, and Cammà, Calogero

Published
2019
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30. Balancing Efficacy and Tolerability of First-Line Systemic Therapies for Advanced Hepatocellular Carcinoma: A Network Meta-Analysis.

Author

Celsa, Ciro, Cabibbo, Giuseppe, Pinato, David James, Di Maria, Gabriele, Enea, Marco, Vaccaro, Marco, Battaglia, Salvatore, Rizzo, Giacomo Emanuele Maria, Giuffrida, Paolo, Giacchetto, Carmelo Marco, Rancatore, Gabriele, Grassini, Maria Vittoria, and Cammà, Calogero

Subjects
IMMUNE checkpoint inhibitors, SURVIVAL rate, PROTEIN-tyrosine kinase inhibitors, OVERALL survival, ENDOTHELIAL growth factors, HEPATOCELLULAR carcinoma
Abstract

Background: Atezolizumab + bevacizumab represent the current standard of care for first-line treatment of advanced hepatocellular carcinoma (HCC). However, direct comparison with other combination treatments including immune checkpoint inhibitors (ICI) + tyrosine kinase inhibitors (TKIs) are lacking. Objectives: This network meta-analysis (NMA) aims to indirectly compare the efficacy and the safety of first-line systemic therapies for unresectable advanced HCC. Method: A literature search of MEDLINE, Embase, and SCOPUS databases was conducted up to October 31, 2022. Phase 3 randomized controlled trials (RCTs) testing TKIs, including sorafenib and lenvatinib, or ICIs reporting overall survival (OS) and progression-free survival (PFS) were included. Individual survival data were extracted from OS and PFS curves to calculate restricted mean survival time. A Bayesian NMA was performed to compare treatments in terms of efficacy (15- and 30-month OS, 6-month PFS) and safety, represented by grade ≥3 (severe) adverse events (SAEs). The incremental safety-effectiveness ratio as measure of net health benefit was calculated as the difference in SAE probability divided by survival difference between the 2 most effective treatments. Results: Nine RCTs enrolling 6,600 patients were included. Atezolizumab plus bevacizumab showed the highest probability (88%) of achieving the 30-month OS landmark. Lenvatinib showed a probability of 86% of achieving best PFS outcomes. ICI monotherapies ranked as most tolerable. Atezolizumab plus bevacizumab showed the best net health benefit for OS, compared to durvalumab plus tremelimumab. When evaluating the net health benefit for PFS, at a willingness-to-risk threshold of 10% of SAEs for life-month gained, atezolizumab plus bevacizumab was favoured in 78% of cases, while at threshold of 30% of SAEs for life-month gained, lenvatinib was favoured in 76% of cases. Conclusions: Atezolizumab plus bevacizumab is the best treatment in terms of net benefit and therefore it should be recommended as standard of care. Compared to atezolizumab plus bevacizumab, lenvatinib monotherapy had the best net benefit for PFS when physicians and patients are available to accept a higher risk of toxicity. [ABSTRACT FROM AUTHOR]

Published
2024
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32. Landscape of alcohol-related hepatocellular carcinoma in the last 15 years highlights the need to expand surveillance programs

Author

Reggidori, Nicola, primary, Bucci, Laura, additional, Santi, Valentina, additional, Stefanini, Benedetta, additional, Lani, Lorenzo, additional, Rampoldi, Davide, additional, Ghittoni, Giorgia, additional, Farinati, Fabio, additional, Masotto, Alberto, additional, Stefanini, Bernardo, additional, Mega, Andrea, additional, Biasini, Elisabetta, additional, Foschi, Francesco Giuseppe, additional, Svegliati-Baroni, Gianluca, additional, Sangiovanni, Angelo, additional, Campani, Claudia, additional, Raimondo, Giovanni, additional, Vidili, Gianpaolo, additional, Gasbarrini, Antonio, additional, Celsa, Ciro, additional, Di Marco, Mariella, additional, Giannini, Edoardo G., additional, Sacco, Rodolfo, additional, Brunetto, Maurizia Rossana, additional, Azzaroli, Francesco, additional, Magalotti, Donatella, additional, Morisco, Filomena, additional, Rapaccini, Gian Ludovico, additional, Nardone, Gerardo, additional, Vitale, Alessandro, additional, Trevisani, Franco, additional, Biselli, Maurizio, additional, Caraceni, Paolo, additional, Gramenzi, Annagiulia, additional, Benevento, Francesca, additional, Granito, Alessandro, additional, Muratori, Luca, additional, Piscaglia, Fabio, additional, Tovoli, Francesco, additional, Allegrini, Gloria, additional, Cammà, Calogero, additional, Cabibbo, Giuseppe, additional, Giacchetto, Carmelo Marco, additional, Giuffrida, Paolo, additional, Grassini, Maria Vittoria, additional, Grova, Mauro, additional, Rancatore, Gabriele, additional, Stornello, Caterina, additional, Adotti, Valentina, additional, Cavoli, Tancredi Li, additional, Marra, Fabio, additional, Rosi, Martina, additional, Bevilacqua, Vittoria, additional, Borghi, Alberto, additional, Napoli, Lucia, additional, Conti, Fabio, additional, Frassineti, G.L., additional, Migliano, Maria Teresa, additional, de Matthaeis, Nicoletta, additional, Ponziani, Francesca Romana, additional, Missale, Gabriele, additional, Olivani, Andrea, additional, Capasso, Mario, additional, Cossiga, Valentina, additional, Guarino, Maria, additional, Marina Cela, Ester, additional, Facciorusso, Antonio, additional, Graziosi, Camilla, additional, Lauria, Valentina, additional, Pelecca, Giorgio, additional, Schirripa, Marta, additional, Chegai, Fabrizio, additional, Raso, Armando, additional, Bozzi, Alessio, additional, Franzè, Maria Stella, additional, Saitta, Carlo, additional, Sauchella, Assunta, additional, Dajti, Elton, additional, Ravaioli, Federico, additional, Plaz Torres, Maria Corina, additional, Pieri, Giulia, additional, Oliveri, Filippo, additional, Ricco, Gabriele, additional, Romagnoli, Veronica, additional, Inno, Alessandro, additional, Marchetti, Fabiana, additional, Coccoli, Pietro, additional, Malerba, Antonio, additional, Cappelli, Alberta, additional, Golfieri, Rita, additional, Mosconi, Cristina, additional, and Renzulli, Matteo, additional

Published
2023
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33. Balancing Efficacy and Tolerability of First-Line Systemic Therapies for Advanced Hepatocellular Carcinoma: A Network Meta-Analysis

Author

Celsa, Ciro, primary, Cabibbo, Giuseppe, additional, Pinato, David James, additional, Di Maria, Gabriele, additional, Enea, Marco, additional, Vaccaro, Marco, additional, Battaglia, Salvatore, additional, Rizzo, Giacomo Emanuele Maria, additional, Giuffrida, Paolo, additional, Giacchetto, Carmelo Marco, additional, Rancatore, Gabriele, additional, Grassini, Maria Vittoria, additional, and Cammà, Calogero, additional

Published
2023
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34. Balancing efficacy and tolerability of first-line systemic therapies for advanced hepatocellular carcinoma: a network metanalysis

Author

Celsa, Ciro, primary, Cabibbo, Giuseppe, additional, Di Maria, Gabriele, additional, Vaccaro, Marco, additional, Battaglia, Salvatore, additional, Maria Rizzo, Giacomo Emanuele, additional, Ciccia, Roberta, additional, Grova, Alessandro, additional, Salvato, Mauro, additional, Giuffrida, Paolo, additional, Giacchetto, Marco, additional, Rancatore, Gabriele, additional, Grassini, Maria Vittoria, additional, Antonucci, Michela, additional, Morana, Piera, additional, Enea, Marco, additional, and Camma, Calogero, additional

Published
2023
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35. RESIST criteria accurately rule-out high-risk esophageal varices in patients with primary biliary cholangitis and compensated advanced chronic liver disease

Author

Calvaruso, Vincenza, primary, Celsa, Ciro, additional, Cristoferi, Laura, additional, Scaravaglio, Miki, additional, Capodicasa, Luigi, additional, Cadamuro, Luca, additional, Di Maria, Gabriele, additional, Di Marco, Vito, additional, Gerussi, Alessio, additional, Malinverno, Federica, additional, Lampertico, Pietro, additional, Cazzagon, Nora, additional, Marzioni, Marco, additional, Gentilucci, Umberto Vespasiani, additional, Andreone, Pietro, additional, Lleo, Ana, additional, Rigamonti, Cristina, additional, Giannini, Edoardo Giovanni, additional, Russello, Maurizio, additional, Vanni, Ester, additional, Cerini, Federica, additional, Missale, Gabriele, additional, Brunetto, Maurizia, additional, Niro, Grazia, additional, Vettori, Giovanni, additional, Castellaneta, Antonino, additional, Alvaro, Domenico, additional, Palitti, Valeria Pace, additional, Bellanti, Francesco, additional, Invernizzi, Pietro, additional, Camma, Calogero, additional, and Carbone, Marco, additional

Published
2023
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36. Risk factors for viral reactivation in patients with overt or occult HepatitisB Virus infection receiving immunosuppressive treatments: a systematic review and meta-analysis

Author

Celsa, Ciro, primary, Maria Rizzo, Giacomo Emanuele, additional, Rancatore, Gabriele, additional, Graceffa, Pietro, additional, Falco, Giuseppe, additional, Di Maria, Gabriele, additional, Vaccaro, Marco, additional, Enea, Marco, additional, Calvaruso, Vincenza, additional, Camma, Calogero, additional, and Di Marco, Vito, additional

Published
2023
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37. Hepatic encephalopathy increases the risk for mortality and hospital readmission in decompensated cirrhotic patients: a prospective multicenter study

Author

Riggio, Oliviero, primary, Celsa, Ciro, additional, Calvaruso, Vincenza, additional, Merli, Manuela, additional, Caraceni, Paolo, additional, Montagnese, Sara, additional, Mora, Vincenzina, additional, Milana, Martina, additional, Saracco, Giorgio Maria, additional, Raimondo, Giovanni, additional, Benedetti, Antonio, additional, Burra, Patrizia, additional, Sacco, Rodolfo, additional, Persico, Marcello, additional, Schepis, Filippo, additional, Villa, Erica, additional, Colecchia, Antonio, additional, Fagiuoli, Stefano, additional, Pirisi, Mario, additional, Barone, Michele, additional, Azzaroli, Francesco, additional, Soardo, Giorgio, additional, Russello, Maurizio, additional, Morisco, Filomena, additional, Labanca, Sara, additional, Fracanzani, Anna Ludovica, additional, Pietrangelo, Antonello, additional, Di Maria, Gabriele, additional, Nardelli, Silvia, additional, Ridola, Lorenzo, additional, Gasbarrini, Antonio, additional, and Cammà, Calogero, additional

Published
2023
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38. Qualification of major pathological response as a surrogate endpoint for relapse-free survival following neoadjuvant immunotherapy for hepatocellular carcinoma.

Author

D'Alessio, Antonio, Stefanini, Bernardo, Blanter, Julia, Adegbite, Benjamin, Fulgenzi, Claudia A.M., Celsa, Ciro, Manfredi, Giulia F, Pai, Madhava, Goldin, Robert D., Shu, Daniel, Su, Yung-Yeh, Baretti, Marina, Anders, Robert A., Yarchoan, Mark, Hsu, Chiun, Marron, Thomas Urban, and Pinato, David James

Published
2024
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41. Reply

Author

Vizzutti, Francesco, primary, Celsa, Ciro, additional, Battaglia, Salvatore, additional, Miraglia, Roberto, additional, Enea, Marco, additional, Marra, Fabio, additional, Colecchia, Antonio, additional, Cammà, Calogero, additional, and Schepis, Filippo, additional

Published
2023
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42. Personalised management of patients with hepatocellular carcinoma: a multiparametric therapeutic hierarchy concept

Author

Vitale, Alessandro, Cabibbo, Giuseppe, Iavarone, Massimo, Viganò, Luca, Pinato, David J, Ponziani, Francesca Romana, Lai, Quirino, Casadei-Gardini, Andrea, Celsa, Ciro, Galati, Giovanni, Gambato, Martina, Crocetti, Laura, Renzulli, Matteo, Giannini, Edoardo G, Farinati, Fabio, Trevisani, Franco, Cillo, Umberto, Miele, Luca, HCC Special Interest Group of the Italian Association for the Study of the, Liver, Ponziani, Francesca Romana (ORCID:0000-0002-5924-6238), Miele, Luca (ORCID:0000-0003-3464-0068), HCC Special Interest Group of the Italian Association for the Study of the Liver, Vitale, Alessandro, Cabibbo, Giuseppe, Iavarone, Massimo, Viganò, Luca, Pinato, David J, Ponziani, Francesca Romana, Lai, Quirino, Casadei-Gardini, Andrea, Celsa, Ciro, Galati, Giovanni, Gambato, Martina, Crocetti, Laura, Renzulli, Matteo, Giannini, Edoardo G, Farinati, Fabio, Trevisani, Franco, Cillo, Umberto, Miele, Luca, HCC Special Interest Group of the Italian Association for the Study of the, Liver, Ponziani, Francesca Romana (ORCID:0000-0002-5924-6238), Miele, Luca (ORCID:0000-0003-3464-0068), and HCC Special Interest Group of the Italian Association for the Study of the Liver

Abstract

Advances in the surgical and systemic therapeutic landscape of hepatocellular carcinoma have increased the complexity of patient management. A dynamic adaptation of the available staging-based algorithms is required to allow flexible therapeutic allocation. In particular, real-world hepatocellular carcinoma management increasingly relies on factors independent of oncological staging, including patients' frailty, comorbid burden, critical tumour location, multiple liver functional parameters, and specific technical contraindications impacting the delivery of treatment and resource availability. In this Policy Review we critically appraise how treatment allocation strictly based on pretreatment staging features has shifted towards a more personalised treatment approach, in which expert tumour boards assume a central role. We propose an evidence-based framework for hepatocellular carcinoma treatment based on the novel concept of multiparametric therapeutic hierarchy, in which different therapeutic options are ordered according to their survival benefit (ie, from surgery to systemic therapy). Moreover, we introduce the concept of converse therapeutic hierarchy, in which therapies are ordered according to their conversion abilities or adjuvant abilities (ie, from systemic therapy to surgery).

Published
2023

43. Hepatic encephalopathy increases the risk for mortality and hospital readmission in decompensated cirrhotic patients: a prospective multicenter study

Author

Riggio, Oliviero, Celsa, Ciro, Calvaruso, Vincenza, Merli, Manuela, Caraceni, Paolo, Montagnese, Sara, Mora, Vincenzina, Milana, Martina, Saracco, Giorgio Maria, Raimondo, Giovanni, Benedetti, Antonio, Burra, Patrizia, Sacco, Rodolfo, Persico, Marcello, Schepis, Filippo, Villa, Erica, Colecchia, Antonio, Fagiuoli, Stefano, Pirisi, Mario, Barone, Michele, Azzaroli, Francesco, Soardo, Giorgio, Russello, Maurizio, Morisco, Filomena, Labanca, Sara, Fracanzani, Anna Ludovica, Pietrangelo, Antonello, Di Maria, Gabriele, Nardelli, Silvia, Ridola, Lorenzo, Gasbarrini, Antonio, Cammà, Calogero, Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), Riggio, Oliviero, Celsa, Ciro, Calvaruso, Vincenza, Merli, Manuela, Caraceni, Paolo, Montagnese, Sara, Mora, Vincenzina, Milana, Martina, Saracco, Giorgio Maria, Raimondo, Giovanni, Benedetti, Antonio, Burra, Patrizia, Sacco, Rodolfo, Persico, Marcello, Schepis, Filippo, Villa, Erica, Colecchia, Antonio, Fagiuoli, Stefano, Pirisi, Mario, Barone, Michele, Azzaroli, Francesco, Soardo, Giorgio, Russello, Maurizio, Morisco, Filomena, Labanca, Sara, Fracanzani, Anna Ludovica, Pietrangelo, Antonello, Di Maria, Gabriele, Nardelli, Silvia, Ridola, Lorenzo, Gasbarrini, Antonio, Cammà, Calogero, and Gasbarrini, Antonio (ORCID:0000-0002-7278-4823)

Abstract

IntroductionHepatic encephalopathy (HE) affects the survival and quality of life of patients with cirrhosis. However, longitudinal data on the clinical course after hospitalization for HE are lacking. The aim was to estimate mortality and risk for hospital readmission of cirrhotic patients hospitalized for HE. MethodsWe prospectively enrolled 112 consecutive cirrhotic patients hospitalized for HE (HE group) at 25 Italian referral centers. A cohort of 256 patients hospitalized for decompensated cirrhosis without HE served as controls (no HE group). After hospitalization for HE, patients were followed-up for 12 months until death or liver transplant (LT). ResultsDuring follow-up, 34 patients (30.4%) died and 15 patients (13.4%) underwent LT in the HE group, while 60 patients (23.4%) died and 50 patients (19.5%) underwent LT in the no HE group. In the whole cohort, age (HR 1.03, 95% CI 1.01-1.06), HE (HR 1.67, 95% CI 1.08-2.56), ascites (HR 2.56, 95% CI 1.55-4.23), and sodium levels (HR 0.94, 95% CI 0.90-0.99) were significant risk factors for mortality. In the HE group, ascites (HR 5.07, 95% CI 1.39-18.49) and BMI (HR 0.86, 95% CI 0.75-0.98) were risk factors for mortality, and HE recurrence was the first cause of hospital readmission. ConclusionIn patients hospitalized for decompensated cirrhosis, HE is an independent risk factor for mortality and the most common cause of hospital readmission compared with other decompensation events. Patients hospitalized for HE should be evaluated as candidates for LT.

Published
2023

44. Recalibrating survival prediction among patients receiving trans‐arterial chemoembolization for hepatocellular carcinoma

Author

Cucchetti, Alessandro, Giannini, Edoardo G., Mosconi, Cristina, Plaz Torres, Maria Corina, Pieri, Giulia, Farinati, Fabio, Rapaccini, Gian Ludovico, Di Marco, Maria, Caturelli, Eugenio, Sacco, Rodolfo, Cabibbo, Giuseppe, Campani, Claudia, Mega, Andrea, Guarino, Maria, Gasbarrini, Antonio, Svegliati‐Baroni, Gianluca, Foschi, Francesco Giuseppe, Missale, Gabriele, Masotto, Alberto, Nardone, Gerardo, Raimondo, Giovanni, Vidili, Gianpaolo, Brunetto, Maurizia Rossana, Sansone, Vito, Zoli, Marco, Azzaroli, Francesco, Trevisani, Franco, Biselli, Maurizio, Caraceni, Paolo, Gramenzi, Annagiulia, Rampoldi, Davide, Reggidori, Nicola, Santi, Valentina, Stefanini, Benedetta, Granito, Alessandro, Muratori, Luca, Piscaglia, Fabio, Tovoli, Francesco, Magalotti, Donatella, Dajti, Elton, Marasco, Giovanni, Ravaioli, Federico, Cappelli, Alberta, Golfieri, Rita, Renzulli, Matteo, Pelizzaro, Filippo, Penzo, Barbara, Marina Cela, Ester, Facciorusso, Antonio, Cacciato, Valentina, Casagrande, Edoardo, de Matthaeis, Nicoletta, Allegrini, Gloria, Lauria, Valentina, Ghittoni, Giorgia, Pelecca, Giorgio, Chegai, Fabrizio, Coratella, Fabio, Ortenzi, Mariano, Dell'Isola, Serena, Biasini, Elisabetta, Olivani, Andrea, Inno, Alessandro, Marchetti, Fabiana, Celsa, Ciro, Grova, Mauro, Stornello, Caterina, Busacca, Anita, Cammà, Calogero, Maria Rizzo, Giacomo Emanuele, Franzè, Maria Stella, Saitta, Carlo, Sauchella, Assunta, Napoli, Lucia, Bevilacqua, Vittoria, Berardinelli, Dante, Borghi, Alberto, Gardini, Andrea Casadei, Conti, Fabio, Dall'Aglio, Anna Chiara, Ercolani, Giorgio, Marra, Fabio, Di Bonaventura, Chiara, Gitto, Stefano, Adotti, Valentina, Coccoli, Pietro, Malerba, Antonio, Capasso, Mario, Morisco, Filomena, Oliveri, Filippo, Romagnoli, Veronica, Cucchetti, Alessandro, Giannini, Edoardo G., Mosconi, Cristina, Plaz Torres, Maria Corina, Pieri, Giulia, Farinati, Fabio, Rapaccini, Gian Ludovico, Di Marco, Maria, Caturelli, Eugenio, Sacco, Rodolfo, Cabibbo, Giuseppe, Campani, Claudia, Mega, Andrea, Guarino, Maria, Gasbarrini, Antonio, Svegliati‐Baroni, Gianluca, Foschi, Francesco Giuseppe, Missale, Gabriele, Masotto, Alberto, Nardone, Gerardo, Raimondo, Giovanni, Vidili, Gianpaolo, Brunetto, Maurizia Rossana, Sansone, Vito, Zoli, Marco, Azzaroli, Francesco, Trevisani, Franco, Biselli, Maurizio, Caraceni, Paolo, Gramenzi, Annagiulia, Rampoldi, Davide, Reggidori, Nicola, Santi, Valentina, Stefanini, Benedetta, Granito, Alessandro, Muratori, Luca, Piscaglia, Fabio, Tovoli, Francesco, Magalotti, Donatella, Dajti, Elton, Marasco, Giovanni, Ravaioli, Federico, Cappelli, Alberta, Golfieri, Rita, Renzulli, Matteo, Pelizzaro, Filippo, Penzo, Barbara, Marina Cela, Ester, Facciorusso, Antonio, Cacciato, Valentina, Casagrande, Edoardo, de Matthaeis, Nicoletta, Allegrini, Gloria, Lauria, Valentina, Ghittoni, Giorgia, Pelecca, Giorgio, Chegai, Fabrizio, Coratella, Fabio, Ortenzi, Mariano, Dell'Isola, Serena, Biasini, Elisabetta, Olivani, Andrea, Inno, Alessandro, Marchetti, Fabiana, Celsa, Ciro, Grova, Mauro, Stornello, Caterina, Busacca, Anita, Cammà, Calogero, Maria Rizzo, Giacomo Emanuele, Franzè, Maria Stella, Saitta, Carlo, Sauchella, Assunta, Napoli, Lucia, Bevilacqua, Vittoria, Berardinelli, Dante, Borghi, Alberto, Gardini, Andrea Casadei, Conti, Fabio, Dall'Aglio, Anna Chiara, Ercolani, Giorgio, Marra, Fabio, Di Bonaventura, Chiara, Gitto, Stefano, Adotti, Valentina, Coccoli, Pietro, Malerba, Antonio, Capasso, Mario, Morisco, Filomena, Oliveri, Filippo, and Romagnoli, Veronica

Subjects
Liver Cancer, Pre-TACE-Predict model, medicine.medical_specialty, business.industry, Trans-arterial chemoembolization, Pharmaceutical Science, hepatocellular carcinoma, medicine.disease, Gastroenterology, Complementary and alternative medicine, Internal medicine, Hepatocellular carcinoma, medicine, Pharmacology (medical), Trans arterial chemoembolization, business
Abstract

Background & Aims The Pre-TACE-Predict model was devised to assess prognosis of patients treated with trans-arterial chemoembolization (TACE) for hepatocellular carcinoma (HCC). However, before entering clinical practice, a model should demonstrate that it performs a useful role. Methods We performed an independent external validation of the Pre-TACE model in a cohort that differs in setting and time period from the one that generated the original model. Data from 826 patients treated with TACE for naïve HCC (2008-2018) were used to assess calibration and discrimination of the Pre-TACE-Predict model. Results The four risk-categories identified by the Pre-TACE-Predict model had gradient monotonicity, with median survivals of 52.0, 36.2, 29.9, and 14.1 months respectively. However, predicted survivals systematically underestimated observed survivals (R2: 0.667). A recalibration was adopted maintaining fixed the prognostic index and modifying the baseline survival function. This resulted in an almost perfect calibration (R2: 0.995) in all the four risk categories. Cox regressions showed that aetiology and macrovascular invasion, included in the Pre-TACE-Predict model, had no prognostic impact in the present study population, and that coefficients for tumour size and multiplicity were overestimated. The c-index was similar to that of the m-HAP-III, but higher than those of HAP, m-HAP-II and the six-and-twelve models. Conclusions The recalibration of Pre-TACE-Predict model improved the estimation of survival probabilities of HCC patients treated with TACE. The highest discriminatory ability of the Pre-TACE-model in comparison to other available models, together with risk stratification and recalibration, makes it the best prognostic tool currently available for these patients.

Published
2021

46. Reliability of grading preoperative pancreatic neuroendocrine tumors on EUS specimens: a systematic review with meta-analysis of aggregate and individual data

Author

Tacelli, Matteo, primary, Bina, Niccolò, additional, Crinò, Stefano Francesco, additional, Facciorusso, Antonio, additional, Celsa, Ciro, additional, Vanni, Andrea Sbrozzi, additional, Fantin, Alberto, additional, Antonini, Filippo, additional, Falconi, Massimo, additional, Monica, Fabio, additional, Capurso, Gabriele, additional, Arcidiacono, Paolo Giorgio, additional, and Barresi, Luca, additional

Published
2022
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47. The Evolving Scenario in the Assessment of Radiological Response for Hepatocellular Carcinoma in the Era of Immunotherapy: Strengths and Weaknesses of Surrogate Endpoints

Author

Giuffrida, Paolo, primary, Celsa, Ciro, additional, Antonucci, Michela, additional, Peri, Marta, additional, Grassini, Maria Vittoria, additional, Rancatore, Gabriele, additional, Giacchetto, Carmelo Marco, additional, Cannella, Roberto, additional, Incorvaia, Lorena, additional, Corsini, Lidia Rita, additional, Morana, Piera, additional, La Mantia, Claudia, additional, Badalamenti, Giuseppe, additional, Brancatelli, Giuseppe, additional, Cammà, Calogero, additional, and Cabibbo, Giuseppe, additional

Published
2022
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49. Reply

Author

Vizzutti, Francesco, primary, Celsa, Ciro, additional, Battaglia, Salvatore, additional, Miraglia, Roberto, additional, Enea, Marco, additional, Marra, Fabio, additional, Caporali, Cristian, additional, Cammà, Calogero, additional, and Schepis, Filippo, additional

Published
2022
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50. Effect of pharmacological interventions and placebo on liver Histology in nonalcoholic steatohepatitis: A network meta-analysis

Author

Pennisi, Grazia, primary, Celsa, Ciro, additional, Enea, Marco, additional, Vaccaro, Marco, additional, Di Marco, Vito, additional, Ciccioli, Carlo, additional, Infantino, Giuseppe, additional, La Mantia, Claudia, additional, Parisi, Stefanie, additional, Vernuccio, Federica, additional, Craxì, Antonio, additional, Cammà, Calogero, additional, and Petta, Salvatore, additional

Published
2022
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