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25 results on '"Cen, Bohong"'

4. Opportunities and challenges of hepatocellular carcinoma organoids for targeted drugs sensitivity screening

Author

Xie, Cuiying, primary, Gu, Ancheng, additional, Khan, Muhammad, additional, Yao, Xiangcao, additional, Chen, Leping, additional, He, Jiali, additional, Yuan, Fumiao, additional, Wang, Ping, additional, Yang, Yufan, additional, Wei, Yerong, additional, Tang, Fang, additional, Su, Hualong, additional, Chen, Jiamin, additional, Li, Jinxia, additional, Cen, Bohong, additional, and Xu, Zhongyuan, additional

Published
2023
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5. Upregulated Long Non-coding RNA Lnc-MRPL39-2:1 Induces the Growth and Invasion of Nasopharyngeal Carcinoma by Binding to HuR and Stabilizing β-Catenin mRNA

Author

Tian, Yunhong, primary, Ai, Meiling, additional, Liu, Chunshan, additional, Wu, Yuchao, additional, Khan, Muhammad, additional, Wang, Baiyao, additional, Long, Huidong, additional, Huang, Chunyue, additional, Lin, Jie, additional, Xu, Anan, additional, Li, Rong, additional, Cen, Bohong, additional, Qiu, Wenze, additional, Xie, Guofeng, additional, and Yuan, Yawei, additional

Published
2023
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15. TCGA and ESTIMATE data mining to identify potential prognostic biomarkers in HCC patients

Author

He, Guolin, primary, Fu, Shunjun, additional, Li, Yang, additional, Li, Ting, additional, Mei, Purong, additional, Feng, Lei, additional, Cai, Lei, additional, Cheng, Yuan, additional, Zhou, Chenjie, additional, Tang, Yujun, additional, Huang, Wenbin, additional, Liu, Haiyan, additional, Cen, Bohong, additional, Pan, Mingxin, additional, and Gao, Yi, additional

Published
2020
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17. An Efficient Bivalent Cyclic RGD-PIK3CB siRNA Conjugate for Specific Targeted Therapy against Glioblastoma In Vitro and In Vivo

Author

Cen, Bohong, primary, Wei, Yuanyi, additional, Huang, Wen, additional, Teng, Muzhou, additional, He, Shuai, additional, Li, Jianlong, additional, Wang, Wei, additional, He, Guolin, additional, Bai, Xin, additional, Liu, Xiaoxia, additional, Yuan, Yawei, additional, Pan, Xinghua, additional, and Ji, Aimin, additional

Published
2018
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22. LncRNA-N1LR Enhances Neuroprotection Against Ischemic Stroke Probably by Inhibiting p53 Phosphorylation.

Author

Wu, Zhuomin, Wu, Ping, Zuo, Xialin, Yu, Na, Qin, Yixin, Xu, Qian, He, Shuai, Cen, Bohong, Liao, Wenjie, and Ji, Aimin

Abstract

In recent years, long noncoding RNAs (lncRNAs) have been shown to have critical roles in a broad range of cell biological processes. However, the activities of lncRNAs during ischemic stroke remain largely unknown. In this study, we carried out a genome-wide lncRNA microarray analysis in rat brains with ischemia/reperfusion (I/R) injury. The results revealed the differential expression of a subset of lncRNAs. Through the construction of lncRNA-mRNA co-expression networks, we identified lncRNA-N1LR as a novel I/R-induced lncRNA. The functions of lncRNA-N1LR were assessed by silencing and overexpressing this lncRNA in vitro and in vivo. We found that lncRNA-N1LR enhanced cell cycle progression and cell proliferation, and inhibited apoptosis in N2a cells subjected to in vitro ischemia (oxygen-glucose deprivation/reoxygenation, OGD/R). Furthermore, we showed that lncRNA-N1LR reduced neuronal apoptosis and neural cell loss in I/R-induced mouse brains. Mechanistically, we discovered that lncRNA-N1LR promoted neuroprotection probably through the inhibition of p53 phosphorylation on serine 15 in a manner that was independent of its location-associated gene Nck1. In summary, our results indicated that lncRNA-N1LR promoted neuroprotection against ischemic stroke probably by inactivating p53. Thus, we propose that lncRNA-N1LR may serve as a potential target for therapeutic intervention following ischemic brain injury. [ABSTRACT FROM AUTHOR]

Published
2017
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24. Regulation of lncRNA expression

Author

Wu, Zhuomin, primary, Liu, Xiaoxia, additional, Liu, Li, additional, Deng, Houliang, additional, Zhang, Jingjing, additional, Xu, Qian, additional, Cen, Bohong, additional, and Ji, Aimin, additional

Published
2014
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25. [Small interfering RNA-mediated programmed cell death-ligand 1 silencing in human glioma cells enhances human CD8 + T lymphocyte cytotoxicity in vitro ].

Author

Wang Z, Huang W, Cen B, Wei Y, Liao L, Li G, and Ji A

Abstract

Objective: To investigate the effect of small interfering RNA (siRNA)-mediated silencing of programmed cell deathligand 1 (PD-L1) in human glioma cells on the cytotoxicity of human CD8 + T lymphocytes against the modified tumor cells., Methods: A siRNA sequence targeting PD-L1 gene was designed and transfected into human glioma U87 MG cells via lipofectamine 2000, and the gene silencing effect was validated using RT-qPCR, Western blotting, and flow cytometry. The transfected cells were co-cultured with human CD8 + T lymphocytes, and the apoptosis of the tumor cells was analyzed with flow cytometry., Results: The siRNA sequence showed strong PD-L1 gene-silencing effect at both mRNA and protein levels in U87 MG cells. Compared with the control cells, the transfected U87 MG cells showed significantly increased vulnerability to the cytotoxicity of human CD8 + T cells and an obvious reduction of proliferative activity in the co-culture ( P < 0.05)., Conclusions: Transfection of human glioma U87 MG cells with the specific siRNA targeting PD-L1 obviously enhances the toxicity of human T lymphocytes in the co-culture.

Published
2018
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