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With the integration of microgrids (MGs) into power distribution networks, the traditional distribution network transforms into an active distribution network (ADN). For the information privacy of all participants and stakeholders, decentralized optimization algorithms are used to optimize the ADN energy management problem. This paper develops a cyber-resilient distributed ADN economic dispatch algorithm based on a relaxed alternating direction method of multipliers (R-ADMM) considering disruptive but unexpected communication failures in the process of coordinated decision making of distribution networks and MGs. Case studies based on a modified IEEE 33bus distribution system are conducted to evaluate the convergence performance and resilience of the proposed method in the cases of packet dropout and time delay. Simulation results demonstrate that the resilience of the proposed algorithm is better than the classic ADMM algorithm.

Additional file 1: Supplemental Table 1. Telephone Interview of Cognitive Status-40 (TICS-40). Supplemental Table 2. Short Form of the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE). Supplemental Table 3. A linear regression model to adjust for confounding factors in Fig. 2A. Supplemental Table 4. Linear regression models to adjust for confounding factors in Fig. 2B. Supplemental Table 5. A linear regression model to adjust for confounding factors in Fig. 2D. Supplemental Table 6. Linear regression models to adjust for confounding factors in Fig. 2E. Supplemental Table 7. A linear regression model to evaluate risk factors for cognitive impairment as indicated by TICS-40. Supplemental Table 8. A linear regression model to evaluate risk factors for cognitive decline as indicated by IQCODE.

Background: Osteosarcoma is the most common primary bone malignancy in children and adolescents. In order to find factors related to its recurrence, and thus improve recovery prospects, a powerful clinical signature is needed. Long noncoding RNAs (lncRNAs) are essential in osteosarcoma processes and development, and here we report significant lncRNAs to aid in earlier diagnosis of osteosarcoma. Methods: A univariate Cox proportional hazards regression analysis and a multivariate Cox regression analysis were used to analyze osteosarcoma patients’ lncRNA expression data from the Therapeutically Applicable Research To Generate Effective Treatments (TARGET), a public database. Results: A lncRNA signature consisting of three lncRNAs (RP1-261G23.7, RP11-69E11.4 and SATB2-AS1) was selected. The signature was used to sort patients into high-risk and low-risk groups with meaningful recurrence rates (median recurrence time 16.80 vs. >128.22 months, log-rank test, P143.80 months, log-rank test, P=0.006). A multivariate Cox regression analysis showed that the significant lncRNA was an independent prognostic factor for osteosarcoma patients. Functional analysis suggests that these lncRNAs were related to the PI3K-Akt signaling pathway, the Wnt signaling pathway, and the G-protein coupled receptor signaling pathway, all of which have various, important roles in osteosarcoma development. The significant 3-lncRNA set could be a novel prediction biomarker that could aid in treatment and also predict the likelihood of recurrence of osteosarcoma in patients.

Thalictrum ramosum is a plant from Thalictrum genus, and is also one substitute of Coptidis Rhizoma in Chinese folk medicine. Phytochemical investigation on the EtOH extract of T. ramosum led to the isolation of 9 compounds. Their structures were elucidated as berberine (1), columbamine (2), thalidastine (3), magnoflorine (4), 1-(4-hydroxy-3-methoxy)-phenyl-2-[4-(1,2,3-trihydroxy-propyl)-2-methoxy]-phenoxy-1,3-propandiol (5), citroside B (6), glochidionionoside A (7), apigenin 6,8-di-C-β-D-xylopyranoside (8) and hydrangeifolin I (9) through 1D and 2D NMR, MS experiments and comparison with literature data. All compounds are isolated from this plant for the first time.

Neuropilin-1 (NRP-1) is overexpressed in several kinds of cancer cell and contributes to tumor aggressiveness. Recently, the arginine/lysine-rich peptide with C-terminal motifs (R/K)XX(R/K) indicated promising penetrating and transporting capability into NRP-1 positive cancer cells. In the present study, we describe a 131 I-labeled C-end rule motif peptide conjugate, Tyr-tLyp-1, for NRP-1 positive tumor targeting and imaging properties. Briefly, a truncated Lyp-1 peptide was designed to expose its C-end motif and conjugated to tyrosine for radiolabeling after structural modification. The peptide indicated specific binding to A549 cancer cells at 2 μM concentration, and its binding was dependent on NRP-1 expression and could be inhibited by other NRP-1-binding peptides. In vivo imaging of 131 I-labeled Tyr-tLyp-1peptide showed that a subcutaneous A549 xenograft tumor could be visualized using a SPECT/CT scanner. The tumor uptake of 131 I-Tyr-tLyp-1 was 4.77 times higher than the uptake in muscles by SPECT/CT software quantification at 6 h post injection. Together, this study indicated that truncated Lyp-1 peptide could specifically localize in NRP-1 positive tumors and successfully mediate the 131 I radionuclide diagnosis, indicating promising targeted imaging capability for NRP-1 positive tumors. Copyright © 2016 John Wiley & Sons, Ltd.

Three new cycloartane triterpene glycosides, cycloramosides A–C (1–3), were isolated from Thalictrum ramosum B. Boivin. Those compounds were determined as 3-O-α-l-arabinopyranosyl-3β,16β,24S,25,30-pentaolcycloartane-16-O-β-d-glucopyranoside (1), 3-O-α-l-arabinopyranosyl-3β,16β,24S,25,30-pentaolcycloartane-24-O-β-d-glucopyranoside (2) and 3-O-α-l-arabinopyranosyl-3β,16β,24S,25-tetrahydoxylcycloartane-16-O-β-d-glucopyranoside (3), respectively. Their structures were elucidated by hydrolysis and extensive spectroscopic methods including 1D and 2D NMR experiments (1H, 13C, DEPT, COSY, ROESY, HSQC, HMBC) along with HR-ESI–MS analyses.

Mosapride is known to affect gastric motility, however whether mosapride has anti-ulcergenic effects in gastric mucosal injury is unclear. The aim of the present study was to investigate the effects of mosapride on aspirin-induced gastric injuries. GES-1 cells were cultured and divided into 5 groups: Control group, aspirin injury group (treated with 18.2 mmol/l aspirin) and mosapride pretreatment groups (treated with 0.4, 0.5, or 0.6 µmol/l mosapride). Cell proliferation was evaluated via MTT assay and cell apoptosis was investigated via flow cytometry. The expression of occludin was determined by western blot analysis. A total of 40 male Sprague-Dawley rats were randomized into five groups: Control group, aspirin injury group (150 mg/kg) and mosapride pretreatment groups (0.25, 0.50 or 0.75 mg/kg). Gastric mucosal lesions were induced by administering 200 mg/kg aspirin daily for 4 days. Rats in the mosapride groups were pretreated with mosapride 1 h prior to aspirin administration. Histological changes were evaluated under a light microscope and gastric epithelial TJs were observed via transmission electron microscopy. The results revealed that cell apoptosis was significantly increased in the aspirin injury group compared with the control (P

Objective To evaluate the predictive value of ultrasonography of the respiratory variability of inferior vena cava(IVC) in preoperative fluid responsiveness evaluation of geriatric hip fracture patients. Methods From August 2017 to February 2018,44 geriatric patients with hip fractures were admitted in Daping hospital. The maximum diameter (IVCe) and minimum diameter (IVCi) of the IVC were measured by ultrasound and the respiratory variation of IVC (IVC-CI) was calculated before surgery. Patients were grouped to Responsive group(Positive Group) and Non-responsive group(Negative Group) according to Stroke volume variation(u0394SV) increased more than 15%. Heart rate (HR), Mean Artery Pressure (MAP), Cardiac Output (CO) and Stroke Volume (SV) were also recorded. The sensitivity and specificity of IVC-CI to fluid responsiveness evaluation was analyzed by ROC, and the correlation between IVC-CI and u0394SV was analyzed by Spearman correlation analysis. Results 39 patients were included in the study, 5 were excluded. 19 were fluid responsiveness positive (Positive Group) and 18 cases were volume responsiveness negative (Negative Group). Before the volume-loading test, thereu2019s no significant difference in IVCe between the two groups(Puff1e0.05); IVCi in Group R was significantly smaller than Group N, and IVC-CI was significantly larger than Group N, (Puff1c0.05). After the volume-loading test the differences of IVCe, IVCi, IVC-CI between the two groups were not statistically significant (Puff1e0.05). Area under curve (AUC) of IVC-CI for fluid responsiveness evaluation in geriatric hip fracture patients was 0.80u00b10.08 (0.65-0.95, P=0.001), with 20.69% for the cut off value, the sensitivity was 77.78%, specificity was 76.19%. Through the Pearson correlation analysis, IVC-CI and u0394 SV were positively correlated with the coefficient r = 0.367, Puff1c0.05. Conclusion Ultrasonography of the respiratory variability of IVC can predict the preoperative fluid responsiveness of geriatric hip fracture patients.

A novel strategy for the qualitative and quantitative determination of 20(S)-protopanaxatriol saponins (PTS) and 20(S)-protopanaxadiol saponins (PDS) in Panax notoginseng, Panax ginseng and Panax quinquefolium, based on the overlapping peaks of main components of PTS (calibrated by ginsenoside Rg1) and PDS (calibrated by ginsenoside Rb1), was proposed. The analysis was performed by using high-performance liquid chromatography coupled with evaporative light scattering detection (HPLC-ELSD). Under specific chromatographic conditions, all samples showed two overlapping peaks containing several main ginsenosides belonging to PTS and PDS, respectively. The overlapping peaks were also identified by using HPLC-MS. Based on the sum and ratio of PTS and PDS, 60 tested Panax samples were divided into three main clusters according to their species. The findings suggested that this strategy provides a simple and rapid approach to quantify PTS and PDS in Panax herbs.