1. Total Polyphenol Intake Is Inversely Associated with a Pro/Anti-Inflammatory Biomarker Ratio in European Adolescents of the HELENA Study
- Author
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Augustin Scalbert, Viktoria Knaze, Marika Ferrari, Azahara I. Rupérez, Dénes Molnár, Luis A. Moreno, Antonios Kafatos, Stefaan De Henauw, Yannis Manios, Kurt Widhalm, Nathalie Michels, Ratih Wirapuspita Wisnuwardani, Joseph A. Rothwell, Mathilde Kersting, Ascensión Marcos, Frédéric Gottrand, Maria Forsner, Inge Huybrechts, CHU Lille, Inserm, Université de Lille, Universiteit Gent = Ghent University [UGENT], Consiglio per la Ricerca in Agricoltura e l’analisi dell’economia agraria = Council for Agricultural Research and Economics [CREA], Dalarna University, Lille Inflammation Research International Center (LIRIC) - U995, Centre International de Recherche contre le Cancer - International Agency for Research on Cancer [CIRC - IARC], University of Crete [Heraklion] [UOC], Ruhr-Universität Bochum [Bochum], Harokopio University of Athens, Spanish National Research Council [CSIC], University of Pecs, University of Zaragoza - Universidad de Zaragoza [Zaragoza], Medizinische Universität Wien = Medical University of Vienna, European Commission, Indonesia Endowment Fund for Education, Universiteit Gent = Ghent University (UGENT), Consiglio per la Ricerca in Agricoltura e l’analisi dell’economia agraria = Council for Agricultural Research and Economics (CREA), Lille Inflammation Research International Center - U 995 (LIRIC), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Centre International de Recherche contre le Cancer - International Agency for Research on Cancer (CIRC - IARC), Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), University of Crete [Heraklion] (UOC), and Spanish National Research Council (CSIC)
- Subjects
0301 basic medicine ,Male ,medicine.drug_class ,[SDV]Life Sciences [q-bio] ,Population ,Medicine (miscellaneous) ,Physiology ,Inflammation ,medicine.disease_cause ,Dietary Polyphenol ,Anti-inflammatory ,03 medical and health sciences ,0302 clinical medicine ,Limit of Detection ,Health Sciences ,medicine ,Humans ,flavonoid ,030212 general & internal medicine ,education ,Child ,Life Style ,proanthocyanidin ,education.field_of_study ,youth ,030109 nutrition & dietetics ,Nutrition and Dietetics ,business.industry ,Polyphenols ,food and beverages ,Hälsovetenskaper ,polyphenol ,adolescent ,inflammation ,cytokines ,Europe ,Polyphenol ,Biomarker (medicine) ,Female ,medicine.symptom ,Inflammation Mediators ,business ,Oxidative stress ,Biomarkers ,Biomedical sciences - Abstract
[Background]: Although high dietary polyphenol intake is negatively associated with risk of certain inflammation-associated chronic diseases, the underlying mechanisms are not fully understood and few studies have explored this in adolescents., [Objective]: This study aimed to evaluate the association between intakes of total polyphenols, polyphenol classes, and the 10 most commonly consumed individual polyphenols with inflammatory biomarkers in the blood of European adolescents., [Methods]: In the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) Study, 526 adolescents (54% girls; 12.5–17.5 y) had data on inflammatory biomarkers and polyphenol intake from 2 nonconsecutive 24-h recalls via matching with the Phenol-Explorer database. Inflammatory biomarkers in serum were IL-1, IL-2, IL-4, IL-5, IL-6, IL-10, transforming growth factor β1 (TGF-β1), TNF-α, IFN-γ, soluble vascular adhesion molecule 1 (sVCAM-1), soluble intercellular adhesion molecule 1 (sICAM-1), soluble E-selectin (sE-selectin), white blood cells, lymphocytes, T cells, and C-reactive protein. Multilevel linear models were used to test associations of polyphenol intake with a pro/anti-inflammatory biomarker ratio [(zTNF-α + zIL-6 + zIL-1)/3/zIL-10] as well as with separate inflammatory biomarkers, adjusted for sociodemographic variables, diet inflammation index, BMI z score, and serum triglycerides., [Results]: The pro/anti-inflammatory biomarker ratio was linearly inversely associated with the intake of total polyphenols (β = −0.11, P = 0.040). When other inflammation biomarkers were considered, the serum IL-10 concentration was inversely associated with total polyphenol (β = −0.12, P = 0.017) and flavonoid (β = −0.12, P = 0.013) intakes, findings that were inconsistent with the biomarker ratio results. However, the anti-inflammatory capacity of polyphenols was confirmed by positive associations of IL-4 with phenolic acid (β = 0.09 P = 0.049) and stilbene (β = 0.13, P = 0.019) intakes and the negative association of IL-1, IL-2, and IFN-γ with lignan intake (β = −0.10, P = 0.034; β = −0.09, P = 0.049; β = −0.11, P = 0.023)., [Conclusions]: The negative relation with the overall pro/anti-inflammatory biomarker ratio suggests a potential anti-inflammatory role of high polyphenol intakes among European adolescents. Nevertheless, associations are dependent on polyphenol type and the inflammatory biomarker measured., The HELENA (Healthy Lifestyle in Europe by Nutrition in Adolescence) study was carried out with the financial support of the European Community Sixth RTD Framework Program (contract FOODCT-2005-007034). RWW was sponsored as a PhD student by the Indonesia Endowment Fund for Education (LPDP, Indonesia).
- Published
- 2020