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2 results on '"Centre for Tropical Livestock Genetics and Health [Edimburgh] (CTLGH)"'

1. Multilateral benefit-sharing from digital sequence information will support both science and biodiversity conservation

Author

Amber Hartman Scholz, Jens Freitag, Christopher H. C. Lyal, Rodrigo Sara, Martha Lucia Cepeda, Ibon Cancio, Scarlett Sett, Andrew Lee Hufton, Yemisrach Abebaw, Kailash Bansal, Halima Benbouza, Hamadi Iddi Boga, Sylvain Brisse, Michael W. Bruford, Hayley Clissold, Guy Cochrane, Jonathan A. Coddington, Anne-Caroline Deletoille, Felipe García-Cardona, Michelle Hamer, Raquel Hurtado-Ortiz, Douglas W. Miano, David Nicholson, Guilherme Oliveira, Carlos Ospina Bravo, Fabian Rohden, Ole Seberg, Gernot Segelbacher, Yogesh Shouche, Alejandra Sierra, Ilene Karsch-Mizrachi, Jessica da Silva, Desiree M. Hautea, Manuela da Silva, Mutsuaki Suzuki, Kassahun Tesfaye, Christian Keambou Tiambo, Krystal A. Tolley, Rajeev Varshney, María Mercedes Zambrano, Jörg Overmann, European Commission, Leibniz-Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH / Leibniz Institute DSMZ-German Collection of Microorganisms and Cell Cultures (DSMZ), Leibniz Institute of Plant Genetics and Crop Plant Research [Gatersleben] (IPK-Gatersleben), The Natural History Museum [London] (NHM), One Planet Solutions, Montpellier, Universidad de los Andes [Bogota] (UNIANDES), European Marine Biological Resource Centre (EMBRC-ERIC), Ethiopian Biotechnology Institute, Addis Ababa, National Academy of Agricultural Science and Global Plant Council, New Delhi, National Council of Scientific Research and Technologies (NCSRT), Algiers (NCSRT), Ministry of Agriculture, Livestock, Fisheries and Cooperatives, Nairobi, Institut Pasteur [Paris] (IP), Cardiff University, The Wellcome Trust Sanger Institute [Cambridge], European Bioinformatics Institute [Hinxton] (EMBL-EBI), EMBL Heidelberg, Global Genome Initiative, Smithsonian National Museum of Natural History, Washington, DC, Alexander von Humboldt Biological Resources Research Institute, Bogota, South African National Biodiversity Institute, University of Nairobi (UoN), Instituto Tecnológico Vale [Belém, Brazil] (ITV), Ministry of the Environment and Sustainable Developmentment, University of Lethbridge, Natural History Museum of Denmark, Faculty of Science [Copenhagen], University of Copenhagen = Københavns Universitet (UCPH)-University of Copenhagen = Københavns Universitet (UCPH), University of Freiburg [Freiburg], National Centre for Cell Science [Pune, India] (NCCS), Mariano Galvez University, Guatemala City, National Center for Biotechnology Information (NCBI), University of Johannesburg [South Africa] (UJ), University of the Philippines Los Baños (UP Los Baños), Fundação Oswaldo Cruz / Oswaldo Cruz Foundation (FIOCRUZ), Réseau International des Instituts Pasteur (RIIP), National Institute of Genetics (NIG), Institute of Biotechnology [Vilnius], Life Science Center [Vilnius], Vilnius University [Vilnius]-Vilnius University [Vilnius], Centre for Tropical Livestock Genetics and Health [Edimburgh] (CTLGH), Murdoch University, Corporación CorpoGen, Bogota, Technische Universität Braunschweig = Technical University of Braunschweig [Braunschweig], This work was funded by the German Federal Ministry of Education and Research (BMBF) WiLDSI 031B0862 (A.H.S., J.O., and J.F.) and Horizon Europe EVA-GLOBAL 871029 (A.H.S.). I.K.M. was supported by the National Center for Biotechnology Information of the National Library of Medicine, National Institutes of Health., European Project: 871029,H2020,H2020-INFRAIA-2019-1,EVA-GLOBAL(2020), and European Project: 01UU1602A/C

Subjects
Conservation of Natural Resources, Multidisciplinary, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, General Physics and Astronomy, General Chemistry, Biodiversity, General Biochemistry, Genetics and Molecular Biology
Abstract

Open access to sequence data is a cornerstone of biology and biodiversity research, but has created tension under the United Nations Convention on Biological Diversity (CBD). Policy decisions could compromise research and development, unless a practical multilateral solution is implemented. This workwas funded by the German Federal Ministry of Education and Research (BMBF) WiLDSI 031B0862 (A.H.S., J.O., and J.F.) and Horizon Europe EVA-GLOBAL 871029 (A.H.S.). I.K.M. was supported by the National Center for Biotechnology Information of the National Library of Medicine, National Institutes of Health.

Published
2022
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2. VarGoats project : a dataset of 1159 whole-genome sequences to dissect Capra hircus global diversity

Author

Denoyelle, L., Talouarn, E., Bardou, P., Colli, L., Alberti, A., Danchin, C., Del Corvo, M., Engelen, S., Orvain, C., Palhiere, I., Rupp, R., Sarry, J., Salavati, M., Amills, M., Clark, E., Crepaldi, P., Faraut, T., Masiga, C. W., Pompanon, F., Rosen, B. D., Stella, A., Van Tassell, C. P., Tosser-Klopp, G., Kijas, J., Guldbrandtsen, B., Kantanen, J., Duby, D., Martin, P., Duclos, D., Allain, D., Arquet, R., Mandonnet, N., Naves, M., Carolan, S., Foran, M., Crisa, A., Marletta, D., Ottino, M., Randi, E., Benjelloun, B., Lenstra, H., Moaeen-ud-Din, M., Reecy, J., Goyache, F., Alvarez, I., Capote, J., Jordana, J., Pons, A., Martinez, A., Molina, A., Rosen, B., Drogemuller, C., Luikart, G., Mruttu, H. A., Gondwe, T., Sikosana, J., Taela, M. D. G., Nash, O., Agence Nationale de la Recherche (France), Région Occitanie / Pyrénées-Méditerranée, Ministère de l’Enseignement supérieur et de la Recherche (France), Biotechnology and Biological Sciences Research Council (UK), Bill & Melinda Gates Foundation, Department for International Development (UK), Center for Tropical Studies and Conservation (US), University of Edinburgh, Scottish Government's Rural and Environment Science and Analytical Services, Laboratoire d'Ecologie Alpine (LECA ), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Génétique Physiologie et Systèmes d'Elevage (GenPhySE ), Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT)-École nationale supérieure agronomique de Toulouse (ENSAT), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Système d'Information des GENomes des Animaux d'Elevage (SIGENAE), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Università cattolica del Sacro Cuore [Piacenza e Cremona] (Unicatt), Génomique métabolique (UMR 8030), Genoscope - Centre national de séquençage [Evry] (GENOSCOPE), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université d'Évry-Val-d'Essonne (UEVE)-Centre National de la Recherche Scientifique (CNRS), Institut de l'élevage (IDELE), Università cattolica del Sacro Cuore [Milano] (Unicatt), The Roslin Institute, Biotechnology and Biological Sciences Research Council (BBSRC), Centre for Tropical Livestock Genetics and Health [Edimburgh] (CTLGH), Centre for Research in Agricultural Genomics (CRAG), Università degli Studi di Milano = University of Milan (UNIMI), Tropical Institute of Development Innovations (TRIDI), USDA Agricultural Research Service [Beltsville, Maryland], USDA-ARS : Agricultural Research Service, Consiglio Nazionale delle Ricerche [Milano] (CNR), CSIRO Agriculture and Food (CSIRO), Unité de Recherches Zootechniques (URZ), APIS-GENE, Occitanie region, Ministere de l'Enseignement superieur, de la Recherche et de l'Innovation, United States Agency for International Development (USAID), CGIAR:OPP1127286, ACTIVEGOAT & CAPRISNP projects, UK Research & Innovation (UKRI) : BBS/OS/GC/000012F, ANR-10-INBS-0009,France-Génomique,Organisation et montée en puissance d'une Infrastructure Nationale de Génomique(2010), ANR-11-INBS-0003,CRB-Anim,Réseau de Centres de Ressources Biologiques pour les animaux domestiques(2011), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-École nationale supérieure agronomique de Toulouse [ENSAT]-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Université d'Évry-Val-d'Essonne (UEVE), University of Milan, and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)-Université d'Évry-Val-d'Essonne (UEVE)

Subjects
[SDV.BIO]Life Sciences [q-bio]/Biotechnology, [SDV]Life Sciences [q-bio], Short Communication, Single-nucleotide polymorphism, 610 Medicine & health, Biology, QH426-470, Genome, SF1-1100, Domestication, Animals, Domestication, Genetic Variation, Genomics, Goats, Genome, Genome-Wide Association Study, 03 medical and health sciences, Capra hircus, Genetics, Animals, Indel, Ecology, Evolution, Behavior and Systematics, 030304 developmental biology, Genetic association, 2. Zero hunger, 0303 health sciences, Genetic diversity, [SDV.BA.MVSA]Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health, Settore AGR/17 - ZOOTECNICA GENERALE E MIGLIORAMENTO GENETICO, 630 Agriculture, Goats, 0402 animal and dairy science, Genetic Variation, 04 agricultural and veterinary sciences, General Medicine, Genomics, 15. Life on land, 040201 dairy & animal science, Animal culture, Evolutionary biology, 570 Life sciences, biology, 590 Animals (Zoology), Animal Science and Zoology, Reference genome, Genome-Wide Association Study
Abstract

[Background]: Since their domestication 10,500 years ago, goat populations with distinctive genetic backgrounds have adapted to a broad variety of environments and breeding conditions. The VarGoats project is an international 1000-genome resequencing program designed to understand the consequences of domestication and breeding on the genetic diversity of domestic goats and to elucidate how speciation and hybridization have modeled the genomes of a set of species representative of the genus Capra., [Findings]: A dataset comprising 652 sequenced goats and 507 public goat sequences, including 35 animals representing eight wild species, has been collected worldwide. We identified 74,274,427 single nucleotide polymorphisms (SNPs) and 13,607,850 insertion-deletions (InDels) by aligning these sequences to the latest version of the goat reference genome (ARS1). A Neighbor-joining tree based on Reynolds genetic distances showed that goats from Africa, Asia and Europe tend to group into independent clusters. Because goat breeds from Oceania and Caribbean (Creole) all derive from imported animals, they are distributed along the tree according to their ancestral geographic origin., [Conclusions]: We report on an unprecedented international effort to characterize the genome-wide diversity of domestic goats. This large range of sequenced individuals represents a unique opportunity to ascertain how the demographic and selection processes associated with post-domestication history have shaped the diversity of this species. Data generated for the project will also be extremely useful to identify deleterious mutations and polymorphisms with causal effects on complex traits, and thus will contribute to new knowledge that could be used in genomic prediction and genome-wide association studies., We are grateful to France Génomique “Call for high impact projects” (ANR‐10‐INBS‐09‐08) for selecting our project and providing us the resources to sequence 400 goats. We would like to mention that APIS-GENE funded some WGS sequences through ACTIVEGOAT & CAPRISNP projects. We thank the Occitanie region and the Animal Genetics Division of the French National Institute for Agriculture, Food and Environment (INRAE-GA) for financing the PhD of ET. We thank the Ministère de l'Enseignement supérieur, de la Recherche et de l'Innovation for financing LD. We thank André Eggen (Illumina) for providing chips to genotype 192 animals. We thank the Animal Genetics Division of the French National Institute for Agriculture, Food and Environment (INRAE-GA) for funding VarGoats2 grant, which allowed DNA extraction and genotyping of 384 animals and CRB-Anim, Grant Agreement ANR-11-INBS-0003, (https://crb-anim.fr/) for funding French local breeds sampling. We thank the Italian Goat and Sheep Breeders Association (AssoNaPa) for supporting in sampling. Whole-genome sequencing libraries for the African goats were prepared and sequenced by Edinburgh Genomics and funded via Biotechnology and Biological Sciences Research Council research grant (BBS/OS/GC/000012F) ‘Reference genome and population sequencing of African goats’ awarded to The Roslin Institute. USDA-ARS with funding from USAID funded the collection of samples from Uganda, Tanzania, Malawi, Mozambique and Zimbabwe. EC and MS were partially supported by the Bill & Melinda Gates Foundation and with UK aid from the UK Government’s Department for International Development (Grant Agreement OPP1127286) under the auspices of the Centre for Tropical Livestock Genetics and Health (CTLGH), established jointly by the University of Edinburgh, SRUC (Scotland’s Rural College), and the International Livestock Research Institute. The findings and conclusions contained within are those of the authors and do not necessarily reflect positions or policies of the Bill & Melinda Gates Foundation nor the UK Government.

Published
2021

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