246 results on '"Cereda, Carlo W."'
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2. Effect of Asymptomatic and Symptomatic COVID-19 on Acute Ischemic Stroke Revascularization Outcomes
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Strambo, Davide, Marto, João Pedro, Ntaios, George, Nguyen, Thanh N., Michel, Patrik, Herzig, Roman, Członkowksa, Anna, Demeestere, Jelle, Yassin Mansour, Ossama, Georgiopoulos, Georgios, Nogueira, Raul G., Salerno, Alexander, Wegener, Susanne, Baumgartner, Philipp, Cereda, Carlo W., Bianco, Giovanni, Beyeler, Morin, Arnold, Marcel, Carrera, Emmanuel, Machi, Paolo, Altersberger, Valerian, Bonati, Leo, Gensicke, Henrik, Bolognese, Manuel, Peters, Nils, Wetzel, Stephan, Magriço, Marta, Nuno Ramos, João, Sargento-Freitas, João, Machado, Rita, Maia, Carolina, Machado, Egídio, Paiva-Nunes, Ana, Ferreira, Patrícia, Pinho-e-Melo, Teresa, Carvalho-Dias, Mariana, Paula, André, Alberto Correia, Manuel, Castro, Pedro, Azevedo, Elsa, Albuquerque, Luís, Nuno-Alves, José, Ferreira-Pinto, Joana, Meira, Torcato, Pereira, Liliana, Rodrigues, Miguel, Araújo, André, Rodrigues, Marta, Rocha, Mariana, Pereira-Fonseca, Ângelo, Ribeiro, Luís, Varela, Ricardo, Cappellari, Manuel, Zivelonghi, Cecilia, Sajeva, Giulia, Zini, Andrea, Gentile, Mauro, Forlivesi, Stefano, Migliaccio, Ludovica, Sessa, Maria, Pezzini, Alessandro, Sangalli, Davide, Zedde, Marialuisa, Pascarella, Rosario, Diamanti, Susanna, Beretta, Simone, Schwarz, Ghil, Frisullo, Giovanni, Marcheselli, Simona, Seners, Pierre, Sabben, Candice, Escalard, Simon, Piotin, Michel, Maier, Benjamin, Charbonnier, Guillaume, Vuillier, Fabrice, Legris, Loic, Cuisenier, Pauline, Vodret, Francesca R., Marnat, Gaultier, Liegey, Jean-Sebastien, Sibon, Igor, Flottmann, Fabian, Broocks, Gabriel, Gloyer, Nils-Ole, Bohmann, Ferdinand O., Hendrik Schaefer, Jan, Nolte, Christian H., Audebert, Heinrich, Siebert, Eberhard, Sykora, Marek, Lang, Wilfried, Ferrari, Julia, Mayer-Suess, Lukas, Knoflach, Michael, Gizewski, Elke-Ruth, Stolp, Jeffrey, Stolze, Lotte J., Coutinho, Jonathan M., Nederkoorn, Paul J., van-den-Wijngaard, Ido, de Meris, Joke, Lemmens, Robin, De Raedt, Sylvie, Vandervorst, Fenne, Pierre Rutgers, Matthieu, Guilmot, Antoine, Dusart, Anne, Bellante, Flavio, Calleja-Castaño, Patricia, Ostos, Fernando, Gonzalez-Ortega, Guillermo, Martín-Jiménez, Paloma, García-Madrona, Sebastian, Cruz-Culebras, Antonio, Vera, Rocio, Matute, Maria-Consuelo, Fuentes, Blanca, Alonso-de-Leciñana, María, Rigual, Ricardo, Díez-Tejedor, Exuperio, Pérez-Sánchez, Soledad, Montaner, Joan, Díaz-Otero, Fernando, Perez de la Ossa, Natalia, Flores-Pina, Belén, Muñoz-Narbona, Lucia, Chamorro, Angel, Rodríguez-Vázquez, Alejandro, Renú, Arturo, Ayo-Martin, Oscar, Hernandez-Fernandez, Francisco, Segura, Tomas, Tejada-Meza, Herbert, Hlaing, Thant, See, Isaiah, Simister, Robert, Werring, David J., Saxhaug Kristoffersen, Espen, Nordanstig, Annika, Jood, Katarina, Rentzos, Alexandros, Šimůnek, Libor, Krajíčková, Dagmar, Krajina, Antonín, Mikulík, Robert, Cviková, Martina, Vinklárek, Jan, Školoudík, David, Roubec, Martin, Hurtikova, Eva, Hrubý, Rostislav, Ostry, Svatopluk, Skoda, Ondrej, Pernicka, Marek, Kočí, Lubomír, Eichlová, Zuzana, Jíra, Martin, Kovář, Martin, Panský, Michal, Mencl, Pavel, Paloušková, Hana, Tomek, Aleš, Janský, Petr, Olšerová, Anna, Šrámek, Martin, Havlíček, Roman, Malý, Petr, Trakal, Lukáš, Fiksa, Jan, Slovák, Matěj, Karliński, Michał, Nowak, Maciej, Sienkiewicz-Jarosz, Halina, Bochynska, Anna, Wrona, Pawel, Homa, Tomasz, Sawczynska, Katarzyna, Slowik, Agnieszka, Wlodarczyk, Ewa, Wiącek, Marcin, Tomaszewska-Lampart, Izabella, Sieczkowski, Bartosz, Bartosik-Psujek, Halina, Bilik, Marta, Bandzarewicz, Anna, Dorobek, Malgorzata, Zielińska-Turek, Justyna, Nowakowska-Kotas, Marta, Obara, Krystian, Urbanowski, Paweł, Budrewicz, Sławomir, Guziński, Maciej, Świtońska, Milena, Rutkowska, Iwona, Sobieszak-Skura, Paulina, Łabuz-Roszak, Beata, Dębiec, Aleksander, Staszewski, Jacek, Stępień, Adam, Zwiernik, Jacek, Wasilewski, Grzegorz, Tiu, Cristina, Terecoasă, Elena-Oana, Radu, Razvan-Alexandru, Negrila, Anca, Dorobat, Bogdan, Panea, Cristina, Tiu, Vlad, Petrescu, Simona, Özcan-Özdemir, Atilla, Mahmoud, Mostafa, El-Samahy, Hussam, Abdelkhalek, Hazem, Al-Hashel, Jasem, Ibrahim Ismail, Ismail, Salmeen, Athari, Ghoreishi, Abdoreza, Sabetay, Sergiu, Gross, Hana, Klein, Piers, Abdalkader, Mohamad, Jabbour, Pascal, El Naamani, Kareem, Tjoumakaris, Stavropoula, Abbas, Rawad, Mohamed, Ghada-A., Chebl, Alex, Min, Jiangyong, Hovingh, Majesta, Tsai, Jenny, Khan, Muhib-A., Nalleballe, Krishna, Onteddu, Sanjeeva, Masoud, Hesham E., Michael, Mina, Kaur, Navreet, Maali, Laith, Abraham, Michael, Khandelwal, Priyank, Bach, Ivo, Ong, Melody, Babici, Denis, Khawaja, Ayaz-M., Hakemi, Maryam, Rajamani, Kumar, Cano-Nigenda, Vanessa, Arauz, Antonio, Amaya, Pablo, Llanos, Natalia, Arango, Akemi, Vences, Miguel A., Barrientos, José-Domingo, Caetano, Rayllene, Targa, Rodrigo, Scollo, Sergio, Yalung, Patrick, Nagendra, Shashank, Gaikwad, Abhijit, and Seo, Kwon-Duk
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- 2024
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3. Thrombectomy in Stroke With a Large Vessel Occlusion and Mild Symptoms: “Striving to Better, Oft We Mar What’s Well?”
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Seners, Pierre and Cereda, Carlo W.
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- 2023
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4. Acute neurological disease as a trigger or co-occurrence of transient global amnesia: a case series and systematic review
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Piffer, Silvio, Nannoni, Stefania, Maulucci, Francesco, Beaud, Valérie, Rouaud, Olivier, Cereda, Carlo W., Maeder, Philippe, and Michel, Patrik
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- 2022
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5. Thrombolysis in stroke patients with elevated inflammatory markers
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Altersberger, Valerian L., Enz, Lukas S., Sibolt, Gerli, Hametner, Christian, Nannoni, Stefania, Heldner, Mirjam R., Stolp, Jeffrey, Jovanovic, Dejana R., Zini, Andrea, Pezzini, Alessandro, Wegener, Susanne, Cereda, Carlo W., Ntaios, George, Räty, Silja, Gumbinger, Christoph, Heyse, Miriam, Polymeris, Alexandros A., Zietz, Annaelle, Schaufelbuehl, Anna, Strambo, Davide, Padlina, Giovanna, Slavova, Nedelina, Tiainen, Marjaana, Valkonen, Kati, Velzen, Twan J. van, Bigliardi, Guido, Stanarcevic, Predrag, Magoni, Mauro, Luft, Andreas, Bejot, Yannick, Vandelli, Laura, Padjen, Visnja, Nederkoorn, Paul J., Arnold, Marcel, Michel, Patrik, Ringleb, Peter A., Curtze, Sami, Engelter, Stefan T., and Gensicke, Henrik
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- 2022
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6. Cerebral perfusion imaging predicts final infarct volume after basilar artery thrombectomy
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Yuen, Nicole, Mlynash, Michael, O'Riordan, Andrea, Lansberg, Maarten, Christensen, Soren, Cereda, Carlo W., Bianco, Giovanni, Giurgiutiu, Dan-Victor, Alemseged, Fana, Pileggi, Marco, Campbell, Bruce, Albers, Gregory W., and Heit, Jeremy J.
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- 2023
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7. Absent leptomeningeal collateralization is associated with greatest benefit from mechanical thrombectomy in the 6-24 hour time window
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Dittrich, Tolga D, primary, von Streng, Tennessee, additional, Toebak, Anna M, additional, Zietz, Annaelle, additional, Wagner, Benjamin, additional, Hänsel, Martin, additional, Sutter, Raoul, additional, Katan, Mira, additional, Peters, Nils, additional, Michels, Lars, additional, Kulcsár, Zsolt, additional, Karwacki, Grzegorz M, additional, Pileggi, Marco, additional, Cereda, Carlo W, additional, Wegener, Susanne, additional, Bonati, Leo H, additional, Psychogios, Marios, additional, and De Marchis, Gian Marco, additional
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- 2024
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8. Transient global amnesia with unexpected clinical and radiological findings: A case series and systematic review
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Piffer, Silvio, Nannoni, Stefania, Maulucci, Francesco, Beaud, Valérie, Rouaud, Olivier, Förster, Alex, Cereda, Carlo W., Maeder, Philippe, and Michel, Patrik
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- 2022
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9. Thrombectomy alone versus intravenous alteplase plus thrombectomy in patients with stroke: an open-label, blinded-outcome, randomised non-inferiority trial
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Alonso, Angelika, Arquizan, Caroline, Barreau, Xavier, Beaujeux, Rémy, Behme, Daniel, Boeckh-Behrens, Tobias, Boehme, Christian, Boix, Martí, Boulouis, Grégoire, Bricout, Nicolas, Broc, Nicolas, Cereda, Carlo W., Chabert, Emmanuel, Cho, Tae-Hee, Cianfoni, Alessandro, Costalat, Vincent, Denier, Christian, Di Maria, Frederico, du Mesnil de Rochemont, Richard, Fearon, Patricia, Ferrier, Anna, Fischer, Sebastian, Gauberti, Maxime, Gaudron, Marie, Gimenez, Laetitia, Globas, Christoph, Görtler, Michael, Goyal, Mayank, Hilker-Roggendorf, Ruediger, Hill, Michael D., Hua, Vi Tuan, Humbertjean, Lisa, Jansen, Olav, Jung, Simon, Kägi, Georg, Kelly, Michael E., Kleffner, Ilka, Knoflach, Michael, Nedeltchev, Krassen, Krause, Lars Udo, Lappalainen, Kimmo, Lefebvre, Margaux, Leyon, Joe, Liao, Liang, Liegey, Jean-Sebastien, Loehr, Christian, Michel, Patrik, Nannoni, Stefania, Nicholson, Patrick, Nico, Lorena, Obadia, Michael, Ognard, Julien, Ogungbemi, Ayokunle, Olivot, Jean-Marc, Escalard, Simon, Pasi, Marco, Peeling, Lissa, Perez, Jane, Petersen, Martina, Piechowiak, Eike, Raposo, Roberto, Räty, Silja, Reitz, Sarah C., Remollo, Sebastià, Remonda, Luca, Rennie, Ian, Requena, Manuel, Riabikin, Alexander, Riva, Roberto, Rouchaud, Aymeric, Rosi, Andrea, Rubiera, Marta, Spelle, Laurent, Schnieder, Marlena, Schaafsma, Joanna D., Schubert, Tilman, Schulz, Jörg B., Siddiqui, Mohammed, Soize, Sébastien, Sonnberger, Michael, Touze, Emmanuel, Triquenot, Aude, Turc, Guillaume, Vieira, Lucy, Ben Hassen, Wagih, Wagner, Judith N., Wasser, Katrin, Weber, Johannes, Wenz, Holger, Weisenburger-Lile, David, Wodarg, Fritz, Wolff, Valérie, Wunderlich, Silke, Fischer, Urs, Kaesmacher, Johannes, Strbian, Daniel, Eker, Omer, Cognard, Christoph, Plattner, Patricia S, Bütikofer, Lukas, Mordasini, Pasquale, Deppeler, Sandro, Pereira, Vitor M, Albucher, Jean François, Darcourt, Jean, Bourcier, Romain, Benoit, Guillon, Papagiannaki, Chrysanthi, Ozkul-Wermester, Ozlem, Sibolt, Gerli, Tiainen, Marjaana, Gory, Benjamin, Richard, Sébastien, Liman, Jan, Ernst, Marielle Sophie, Boulanger, Marion, Barbier, Charlotte, Mechtouff, Laura, Zhang, Liqun, Marnat, Gaultier, Sibon, Igor, Nikoubashman, Omid, Reich, Arno, Consoli, Arturo, Lapergue, Bertrand, Ribo, Marc, Tomasello, Alejandro, Saleme, Suzana, Macian, Francisco, Moulin, Solène, Pagano, Paolo, Saliou, Guillaume, Carrera, Emmanuel, Janot, Kevin, Hernández-Pérez, María, Pop, Raoul, Schiava, Lucie Della, Luft, Andreas R, Piotin, Michel, Gentric, Jean Christophe, Pikula, Aleksandra, Pfeilschifter, Waltraud, Arnold, Marcel, Siddiqui, Adnan H, Froehler, Michael T, Furlan, Anthony J, Chapot, René, Wiesmann, Martin, Machi, Paolo, Diener, Hans-Christoph, Kulcsar, Zsolt, Bonati, Leo H, Bassetti, Claudio L, Mazighi, Mikael, Liebeskind, David S, Saver, Jeffrey L, and Gralla, Jan
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- 2022
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10. Supervised and unsupervised learning to define the cardiovascular risk of patients according to an extracellular vesicle molecular signature
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Burrello, Jacopo, Burrello, Alessio, Vacchi, Elena, Bianco, Giovanni, Caporali, Elena, Amongero, Martina, Airale, Lorenzo, Bolis, Sara, Vassalli, Giuseppe, Cereda, Carlo W., Mulatero, Paolo, Bussolati, Benedetta, Camici, Giovanni G., Melli, Giorgia, Monticone, Silvia, and Barile, Lucio
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- 2022
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11. Measurement of Midregional Pro-Atrial Natriuretic Peptide to Discover Atrial Fibrillation in Patients With Ischemic Stroke
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Schweizer, Juliane, Arnold, Markus, König, Inke R., Bicvic, Antonela, Westphal, Laura P., Schütz, Valerie, Inauen, Corinne, Scherrer, Natalie, Luft, Andreas, Galovic, Marian, Ferreira Atuesta, Carolina, Pokorny, Thomas, Arnold, Marcel, Fischer, Urs, Bonati, Leo H., De Marchis, Gian Marco, Kahles, Timo, Nedeltchev, Krassen, Cereda, Carlo W., Kägi, Georg, Bustamante, Alejandro, Montaner, Joan, Ntaios, Georg, Sagris, Dimitrios, Foerch, Christian, Spanaus, Katharina, von Eckardstein, Arnold, and Katan, Mira
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- 2022
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12. Value of intravenous alteplase before thrombectomy among patients with tandem lesions and emergent carotid artery stenting: A subgroup analysis of the SWIFT DIRECT trial.
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Mujanovic, Adnan, Dobrocky, Tomas, Pfeilschifter, Waltraud, Remonda, Luca, Caroff, Jildaz, Behme, Daniel, Seiffge, David J., Cereda, Carlo W., Kägi, Georg, Leyon, Joe, Piechowiak, Eike I., Costalat, Vincent, Wagner, Judith, Chabert, Emmanuel, Meinel, Thomas R., Jansen, Olav, Alonso, Angelika, Loehr, Christian, Liebeskind, David S., and Gralla, Jan
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CAROTID artery ,TREATMENT effect heterogeneity ,INTERNAL carotid artery ,THROMBECTOMY ,SUBGROUP analysis (Experimental design) ,ENDARTERECTOMY - Abstract
Background and purpose: The value of intravenous thrombolysis (IVT) in eligible tandem lesion patients undergoing endovascular treatment (EVT) is unknown. We investigated treatment effect heterogeneity of EVT + IVT versus EVT‐only in tandem lesion patients. Additional analyses were performed for patients undergoing emergent internal carotid artery (ICA) stenting. Methods: SWIFT DIRECT randomized IVT‐eligible patients to either EVT + IVT or EVT‐only. Primary outcome was 90‐day functional independence (modified Rankin Scale score 0–2) after the index event. Secondary endpoints were reperfusion success, 24 h intracranial hemorrhage rate, and 90‐day all‐cause mortality. Interaction models were fitted for all predefined outcomes. Results: Among 408 included patients, 63 (15.4%) had a tandem lesion and 33 (52.4%) received IVT. In patients with tandem lesions, 20 had undergone emergent ICA stenting (EVT + IVT: 9/33, 27.3%; EVT: 11/30, 36.7%). Tandem lesion did not show treatment effect modification of IVT on rates of functional independence (tandem lesion EVT + IVT vs. EVT: 63.6% vs. 46.7%, non‐tandem lesion EVT + IVT vs. EVT: 65.6% vs. 58.2%; p for interaction = 0.77). IVT also did not increase the risk of intracranial hemorrhage among tandem lesion patients (tandem lesion EVT + IVT vs. EVT: 34.4% vs. 46.7%, non‐tandem lesion EVT + IVT vs. EVT: 33.5% vs. 26.3%; p for interaction = 0.15). No heterogeneity was noted for other endpoints (p for interaction > 0.05). Conclusions: No treatment effect heterogeneity of EVT + IVT versus EVT‐only was observed among tandem lesion patients. Administering IVT in patients with anticipated emergent ICA stenting seems safe, and the latter should not be a factor to consider when deciding to administer IVT before EVT. [ABSTRACT FROM AUTHOR]
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- 2024
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13. Sex differences in functional outcomes of intravenous thrombolysis among patients with lacunar stroke
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Wueger, Patrizia, primary, Noseda, Roberta, additional, Pagnamenta, Alberto, additional, Bianco, Giovanni, additional, Seiffge, David, additional, Michel, Patrik, additional, Nedeltchev, Krassen, additional, Bonati, Leo, additional, Kägi, Georg, additional, Niederhauser, Julien, additional, Nyffeler, Thomas, additional, Luft, Andreas, additional, Wegener, Susanne, additional, Schelosky, Ludwig, additional, Medlin, Friedrich, additional, Rodic, Biljana, additional, Peters, Nils, additional, Renaud, Susanne, additional, Mono, Marie Luise, additional, Carrera, Emmanuel, additional, Fischer, Urs, additional, De Marchis, Gian Marco, additional, and Cereda, Carlo W., additional
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- 2024
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14. Collaterals are a major determinant of the core but not the penumbra volume in acute ischemic stroke
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Nannoni, Stefania, Cereda, Carlo W., Sirimarco, Gaia, Lambrou, Dimitris, Strambo, Davide, Eskandari, Ashraf, Dunet, Vincent, Wintermark, Max, and Michel, Patrik
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- 2019
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15. Extracellular Vesicle Surface Markers as a Diagnostic Tool in Transient Ischemic Attacks
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Burrello, Jacopo, Bianco, Giovanni, Burrello, Alessio, Manno, Concetta, Maulucci, Francesco, Pileggi, Marco, Nannoni, Stefania, Michel, Patrik, Bolis, Sara, Melli, Giorgia, Vassalli, Giuseppe, Albers, Gregory W., Cianfoni, Alessandro, Barile, Lucio, and Cereda, Carlo W.
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- 2021
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16. Intravenous Thrombolysis in Patients With Ischemic Stroke Aged ≥90 Years: A Cohort Study From the TRISP Collaboration.
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Altersberger, Valerian L., Rusche, Norman, Martinez-Majander, Nicolas, Hametner, Christian, Scheitz, Jan F., Henon, Hilde, Dell’Acqua, Maria Luisa, Strambo, Davide, Stolp, Jeffrey, Heldner, Mirjam R., Grisendi, Ilaria, Jovanovic, Dejana R., Bejot, Yannick, Pezzini, Alessandro, Leker, Ronen R., Kägi, Georg, Wegener, Susanne, Cereda, Carlo W., Lindgren, Erik, and Ntaios, George
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- 2023
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17. Determining factors of better leptomeningeal collaterals: a study of 857 consecutive acute ischemic stroke patients
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Nannoni, Stefania, Sirimarco, Gaia, Cereda, Carlo W., Lambrou, Dimitris, Strambo, Davide, Eskandari, Ashraf, Mosimann, Pascal J., Wintermark, Max, and Michel, Patrik
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- 2019
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18. Renal Safety of Multimodal Brain Imaging Followed by Endovascular Therapy
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Cereda, Carlo W., Mlynash, Michael, Cippà, Pietro E., Kemp, Stephanie, Heit, Jeremy J., Marks, Michael P., Lansberg, Maarten G., and Albers, Gregory W.
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- 2021
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19. Immune profiling of plasma-derived extracellular vesicles identifies Parkinson disease
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Vacchi, Elena, Burrello, Jacopo, Di Silvestre, Dario, Burrello, Alessio, Bolis, Sara, Mauri, Pierluigi, Vassalli, Giuseppe, Cereda, Carlo W., Farina, Cinthia, Barile, Lucio, Kaelin-Lang, Alain, and Melli, Giorgia
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- 2020
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20. Characteristics and Outcomes in Patients With COVID-19 and Acute Ischemic Stroke: The Global COVID-19 Stroke Registry
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Ntaios, George, Michel, Patrik, Georgiopoulos, Georgios, Guo, Yutao, Li, Wencheng, Xiong, Jing, Calleja, Patricia, Ostos, Fernando, González-Ortega, Guillermo, Fuentes, Blanca, Alonso de Leciñana, María, Díez-Tejedor, Exuperio, García-Madrona, Sebastian, Masjuan, Jaime, DeFelipe, Alicia, Turc, Guillaume, Gonçalves, Bruno, Domigo, Valerie, Dan, Gheorghe-Andrei, Vezeteu, Roxana, Christensen, Hanne, Christensen, Louisa Marguerite, Meden, Per, Hajdarevic, Lejla, Rodriguez-Lopez, Angela, Díaz-Otero, Fernando, García-Pastor, Andrés, Gil-Nuñez, Antonio, Maslias, Errikos, Strambo, Davide, Werring, David J., Chandratheva, Arvind, Benjamin, Laura, Simister, Robert, Perry, Richard, Beyrouti, Rahma, Jabbour, Pascal, Sweid, Ahmad, Tjoumakaris, Stavropoula, Cuadrado-Godia, Elisa, Campello, Ana Rodríguez, Roquer, Jaume, Moreira, Tiago, Mazya, Michael V., Bandini, Fabio, Matz, Karl, Iversen, Helle K., González-Duarte, Alejandra, Tiu, Cristina, Ferrari, Julia, Vosko, Milan R., Salzer, Helmut J.F., Lamprecht, Bernd, Dünser, Martin W., Cereda, Carlo W., Quintero, Ángel Basilio Corredor, Korompoki, Eleni, Soriano-Navarro, Eduardo, Soto-Ramírez, Luis Enrique, Castañeda-Méndez, Paulo F., Bay-Sansores, Daniela, Arauz, Antonio, Cano-Nigenda, Vanessa, Kristoffersen, Espen Saxhaug, Tiainen, Marjaana, Strbian, Daniel, Putaala, Jukka, and Lip, Gregory Y.H.
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- 2020
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21. Recanalization Therapies for Large Vessel Occlusion Due to Cervical Artery Dissection: A Cohort Study of the EVA-TRISP Collaboration
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Traenka, Christopher, Lorscheider, Johannes, Hametner, Christian, Baumgartner, Philipp, Gralla, Jan, Magoni, Mauro, Martinez-Majander, Nicolas, Casolla, Barbara, Feil, Katharina, Pascarella, Rosario, Papanagiotou, Panagiotis, Nordanstig, Annika, Padjen, Visnja, Cereda, Carlo W, Psychogios, Marios, Nolte, Christian H, Zini, Andrea, Michel, Patrik, Béjot, Yannick, Kastrup, Andreas, Zedde, Marialuisa, Kägi, Georg, Kellert, Lars, Henon, Hilde, Curtze, Sami, Pezzini, Alessandro, Arnold, Marcel, Wegener, Susanne, Ringleb, Peter, Tatlisumak, Turgut, Nederkoorn, Paul J, Engelter, Stefan T, and Gensicke, Henrik
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610 Medicine & health - Abstract
BACKGROUND AND PURPOSE This study aimed to investigate the effect of endovascular treatment (EVT, with or without intravenous thrombolysis [IVT]) versus IVT alone on outcomes in patients with acute ischemic stroke (AIS) and intracranial large vessel occlusion (LVO) attributable to cervical artery dissection (CeAD). METHODS This multinational cohort study was conducted based on prospectively collected data from the EVA-TRISP (EndoVAscular treatment and ThRombolysis for Ischemic Stroke Patients) collaboration. Consecutive patients (2015-2019) with AIS-LVO attributable to CeAD treated with EVT and/or IVT were included. Primary outcome measures were (1) favorable 3-month outcome (modified Rankin Scale score 0-2) and (2) complete recanalization (thrombolysis in cerebral infarction scale 2b/3). Odds ratios with 95% confidence intervals (OR [95% CI]) from logistic regression models were calculated (unadjusted, adjusted). Secondary analyses were performed in the patients with LVO in the anterior circulation (LVOant) including propensity score matching. RESULTS Among 290 patients, 222 (76.6%) had EVT and 68 (23.4%) IVT alone. EVT-treated patients had more severe strokes (National Institutes of Health Stroke Scale score, median [interquartile range]: 14 [10-19] vs. 4 [2-7], P
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- 2023
22. Outcome of endovascular therapy in stroke with large vessel occlusion and mild symptoms
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Manno, Concetta, Disanto, Giulio, Bianco, Giovanni, Nannoni, Stefania, Heldner, Mirjam, Jung, Simon, Arnold, Marcel, Kaesmacher, Johannes, Müller, Mandy, Thilemann, Sebastian, Gensicke, Henrik, Carrera, Emmanuel, Fischer, Urs, Kahles, Timo, Luft, Andreas, Nedeltchev, Krassen, Staedler, Claudio, Cianfoni, Alessandro, Kägi, Georg, Bonati, Leo H., Michel, Patrik, and Cereda, Carlo W.
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- 2019
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23. Abstract TP150: Outcome Of Patients With Lacunar Strokes In The Era Of Thrombectomy
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van der Geest, Yael, primary, Disanto, Giulio, additional, Bianco, Giovanni, additional, Sihabdeen, Shairin, additional, Pileggi, Marco, additional, Strambo, Davide, additional, Michel, Patrik, additional, Kahles, Timo, additional, Nedeltchev, Krassen, additional, Fischer, Urs, additional, Bonati, Leo, additional, Kaegi, Georg, additional, Escribano, Jose Bernardo, additional, Carrera, Emmanuel, additional, Nyffeler, Thomas, additional, Bolognese, Manuel, additional, Wegener, Susanne, additional, Luft, Andreas, additional, Medlin, Friedrich, additional, Renaud, Susanne, additional, Mono, Marie-Luise, additional, Remonda, Luca, additional, Machi, Paolo, additional, Psychogios, Marios, additional, Kaesmacher, Johannes, additional, Wardlaw, Joanna M, additional, and Cereda, Carlo W, additional
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- 2023
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24. Imaging Factors Associated With Poor Outcome in Patients With Basilar Artery Occlusion Treated With Endovascular Thrombectomy
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Heit, Jeremy J., primary, Mlynash, Michael, additional, Cereda, Carlo W., additional, Yuen, Nicole, additional, Lansberg, Maarten G., additional, Bianco, Giovanni, additional, Christensen, Soren, additional, Qureshi, Abid Y., additional, Hinduja, Archana, additional, Dehkharghani, Seena, additional, Goldman‐Yassen, Adam E., additional, Hsieh, Kevin Li‐Chun, additional, Giurgiutiu, Dan‐Victor, additional, Gibson, Dan, additional, Carrera, Emmanuel, additional, Alemseged, Fana, additional, Faizy, Tobias D., additional, Fiehler, Jens, additional, Pileggi, Marco, additional, Campbell, Bruce, additional, and Albers, Gregory W., additional
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- 2023
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25. Intravenous Thrombolysis 4.5–9 Hours After Stroke Onset: A Cohort Study from the TRISP Collaboration.
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Altersberger, Valerian L., Sibolt, Gerli, Enz, Lukas S., Hametner, Christian, Scheitz, Jan F., Henon, Hilde, Bigliardi, Guido, Strambo, Davide, Martinez‐Majander, Nicolas, Stolze, Lotte J., Heldner, Mirjam R., Grisendi, Ilaria, Jovanovic, Dejana R., Bejot, Yannick, Pezzini, Alessandro, Leker, Ronen R., Kägi, Georg, Wegener, Susanne, Cereda, Carlo W., and Ntaios, Georges
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MAGNETIC resonance angiography ,INTRACRANIAL hemorrhage ,COHORT analysis ,ISCHEMIC stroke ,THROMBOLYTIC therapy ,STROKE - Abstract
Objective: To investigate the safety and effectiveness of intravenous thrombolysis (IVT) >4.5–9 hours after stroke onset, and the relevance of advanced neuroimaging for patient selection. Methods: Prospective multicenter cohort study from the ThRombolysis in Ischemic Stroke Patients (TRISP) collaboration. Outcomes were symptomatic intracranial hemorrhage, poor 3‐month functional outcome (modified Rankin scale 3–6) and mortality. We compared: (i) IVT >4.5–9 hours versus 0–4.5 hours after stroke onset and (ii) within the >4.5–9 hours group baseline advanced neuroimaging (computed tomography perfusion, magnetic resonance perfusion or magnetic resonance diffusion‐weighted imaging fluid‐attenuated inversion recovery) versus non‐advanced neuroimaging. Results: Of 15,827 patients, 663 (4.2%) received IVT >4.5–9 hours and 15,164 (95.8%) within 4.5 hours after stroke onset. The main baseline characteristics were evenly distributed between both groups. Time of stroke onset was known in 74.9% of patients treated between >4.5 and 9 hours. Using propensity score weighted binary logistic regression analysis (onset‐to‐treatment time >4.5–9 hours vs onset‐to‐treatment time 0–4.5 hours), the probability of symptomatic intracranial hemorrhage (ORadjusted 0.80, 95% CI 0.53–1.17), poor functional outcome (ORadjusted 1.01, 95% CI 0.83–1.22), and mortality (ORadjusted 0.80, 95% CI 0.61–1.04) did not differ significantly between both groups. In patients treated between >4.5 and 9 hours, the use of advanced neuroimaging was associated with a 50% lower mortality compared with non‐advanced imaging only (9.9% vs 19.7%; ORadjusted 0.51, 95% CI 0.33–0.79). Interpretation: This study showed no evidence in difference of symptomatic intracranial hemorrhage, poor outcome, and mortality in selected stroke patients treated with IVT between >4.5 and 9 hours after stroke onset compared with those treated within 4.5 hours. Advanced neuroimaging for patient selection was associated with lower mortality. ANN NEUROL 2023;94:309–320 [ABSTRACT FROM AUTHOR]
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- 2023
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26. Emergency Department (ED) Triage for Transient Ischemic Attack (TIA)
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Cereda, Carlo W. and Olivot, Jean-Marc
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- 2018
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27. MRI or CT for Suspected Acute Stroke: Association of Admission Image Modality with Acute Recanalization Therapies, Workflow Metrics and Outcomes
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Fischer, Urs, Branca, Mattia, Bonati, Leo H, Carrera, Emmanuel, Vargas, Maria I, Platon, Alexandra, Kulcsar, Zsolt, Wegener, Susanne, Luft, Andreas, Seiffge, David J, Arnold, Marcel, Michel, Patrik, Strambo, Davide, Dunet, Vincent, De Marchis, Gian Marco, Schelosky, Ludwig, Andreisek, Gustav, Barinka, Filip, Peters, Nils, Fisch, Loraine, Nedeltchev, Krassen, Cereda, Carlo W, Kägi, Georg, Bolognese, Manuel, Salmen, Stephan, Sturzenegger, Rolf, Medlin, Friedrich, Berger, Christian, Renaud, Susanne, Bonvin, Christophe, Schaerer, Michael, Mono, Marie-Luise, Rodic, Biljana, Psychogios, Marios, Mordasini, Pasquale, Gralla, Jan, Kaesmacher, Johannes, and Meinel, Thomas R
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610 Medicine & health - Abstract
OBJECTIVE To examine rates of intravenous thrombolysis (IVT), mechanical thrombectomy (MT), door-to-needle (DTN) time, door-to-puncture(DTP) time, and functional outcome between patients with admission MRI versus CT. METHODS Observational cohort study of consecutive patients using a target trial design within the nationwide Swiss-Stroke-Registry from 01/2014 to 08/2020. Exclusion criteria included MRI contraindications, transferred patients, and unstable or frail patients. Multilevel mixed-effects logistic regression with multiple imputation was used to calculate adjusted odds ratios with 95% confidence intervals for IVT, MT, DTN, DTP, and good functional outcome (mRS 0-2) at 90 days. RESULTS Of the 11049 patients included (mean [SD] age, 71 [15] years; 4811 [44%] females; 69% ischemic stroke, 16% transient ischemic attack, 8% stroke mimics, 6% intracranial hemorrhage), 3741 (34%) received MRI and 7308 (66%) CT. Patients undergoing MRI had lower NIHSS (median [IQR] 2 [0-6] versus 4 [1-11]), and presented later after symptom onset (150 versus 123 min, P
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- 2022
28. Thrombectomy alone versus intravenous alteplase plus thrombectomy in patients with stroke: an open-label, blinded-outcome, randomised non-inferiority trial
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Fischer, Urs, primary, Kaesmacher, Johannes, additional, Strbian, Daniel, additional, Eker, Omer, additional, Cognard, Christoph, additional, Plattner, Patricia S, additional, Bütikofer, Lukas, additional, Mordasini, Pasquale, additional, Deppeler, Sandro, additional, Pereira, Vitor M, additional, Albucher, Jean François, additional, Darcourt, Jean, additional, Bourcier, Romain, additional, Benoit, Guillon, additional, Papagiannaki, Chrysanthi, additional, Ozkul-Wermester, Ozlem, additional, Sibolt, Gerli, additional, Tiainen, Marjaana, additional, Gory, Benjamin, additional, Richard, Sébastien, additional, Liman, Jan, additional, Ernst, Marielle Sophie, additional, Boulanger, Marion, additional, Barbier, Charlotte, additional, Mechtouff, Laura, additional, Zhang, Liqun, additional, Marnat, Gaultier, additional, Sibon, Igor, additional, Nikoubashman, Omid, additional, Reich, Arno, additional, Consoli, Arturo, additional, Lapergue, Bertrand, additional, Ribo, Marc, additional, Tomasello, Alejandro, additional, Saleme, Suzana, additional, Macian, Francisco, additional, Moulin, Solène, additional, Pagano, Paolo, additional, Saliou, Guillaume, additional, Carrera, Emmanuel, additional, Janot, Kevin, additional, Hernández-Pérez, María, additional, Pop, Raoul, additional, Schiava, Lucie Della, additional, Luft, Andreas R, additional, Piotin, Michel, additional, Gentric, Jean Christophe, additional, Pikula, Aleksandra, additional, Pfeilschifter, Waltraud, additional, Arnold, Marcel, additional, Siddiqui, Adnan H, additional, Froehler, Michael T, additional, Furlan, Anthony J, additional, Chapot, René, additional, Wiesmann, Martin, additional, Machi, Paolo, additional, Diener, Hans-Christoph, additional, Kulcsar, Zsolt, additional, Bonati, Leo H, additional, Bassetti, Claudio L, additional, Mazighi, Mikael, additional, Liebeskind, David S, additional, Saver, Jeffrey L, additional, Gralla, Jan, additional, Alonso, Angelika, additional, Arquizan, Caroline, additional, Barreau, Xavier, additional, Beaujeux, Rémy, additional, Behme, Daniel, additional, Boeckh-Behrens, Tobias, additional, Boehme, Christian, additional, Boix, Martí, additional, Boulouis, Grégoire, additional, Bricout, Nicolas, additional, Broc, Nicolas, additional, Cereda, Carlo W., additional, Chabert, Emmanuel, additional, Cho, Tae-Hee, additional, Cianfoni, Alessandro, additional, Costalat, Vincent, additional, Denier, Christian, additional, Di Maria, Frederico, additional, du Mesnil de Rochemont, Richard, additional, Fearon, Patricia, additional, Ferrier, Anna, additional, Fischer, Sebastian, additional, Gauberti, Maxime, additional, Gaudron, Marie, additional, Gimenez, Laetitia, additional, Globas, Christoph, additional, Görtler, Michael, additional, Goyal, Mayank, additional, Hilker-Roggendorf, Ruediger, additional, Hill, Michael D., additional, Hua, Vi Tuan, additional, Humbertjean, Lisa, additional, Jansen, Olav, additional, Jung, Simon, additional, Kägi, Georg, additional, Kelly, Michael E., additional, Kleffner, Ilka, additional, Knoflach, Michael, additional, Nedeltchev, Krassen, additional, Krause, Lars Udo, additional, Lappalainen, Kimmo, additional, Lefebvre, Margaux, additional, Leyon, Joe, additional, Liao, Liang, additional, Liegey, Jean-Sebastien, additional, Loehr, Christian, additional, Michel, Patrik, additional, Nannoni, Stefania, additional, Nicholson, Patrick, additional, Nico, Lorena, additional, Obadia, Michael, additional, Ognard, Julien, additional, Ogungbemi, Ayokunle, additional, Olivot, Jean-Marc, additional, Escalard, Simon, additional, Pasi, Marco, additional, Peeling, Lissa, additional, Perez, Jane, additional, Petersen, Martina, additional, Piechowiak, Eike, additional, Raposo, Roberto, additional, Räty, Silja, additional, Reitz, Sarah C., additional, Remollo, Sebastià, additional, Remonda, Luca, additional, Rennie, Ian, additional, Requena, Manuel, additional, Riabikin, Alexander, additional, Riva, Roberto, additional, Rouchaud, Aymeric, additional, Rosi, Andrea, additional, Rubiera, Marta, additional, Spelle, Laurent, additional, Schnieder, Marlena, additional, Schaafsma, Joanna D., additional, Schubert, Tilman, additional, Schulz, Jörg B., additional, Siddiqui, Mohammed, additional, Soize, Sébastien, additional, Sonnberger, Michael, additional, Touze, Emmanuel, additional, Triquenot, Aude, additional, Turc, Guillaume, additional, Vieira, Lucy, additional, Ben Hassen, Wagih, additional, Wagner, Judith N., additional, Wasser, Katrin, additional, Weber, Johannes, additional, Wenz, Holger, additional, Weisenburger-Lile, David, additional, Wodarg, Fritz, additional, Wolff, Valérie, additional, and Wunderlich, Silke, additional
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- 2022
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29. Factors Associated With Focal Computed Tomographic Perfusion Abnormalities in Supratentorial Transient Ischemic Attacks
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Meyer, Ivo A., Cereda, Carlo W., Correia, Pamela N., Zerlauth, Jean-Baptiste, Puccinelli, Francesco, Rotzinger, David C., Amiguet, Michael, Maeder, Philippe, Meuli, Reto A., and Michel, Patrik
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- 2018
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30. SARS-CoV-2 and Stroke Characteristics
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Shahjouei, Shima, Tsivgoulis, Georgios, Farahmand, Ghasem, Koza, Eric, Mowla, Ashkan, Vafaei Sadr, Alireza, Kia, Arash, Vaghefi Far, Alaleh, Mondello, Stefania, Cernigliaro, Achille, Ranta, Annemarei, Punter, Martin, Khodadadi, Faezeh, Naderi, Soheil, Sabra, Mirna, Ramezani, Mahtab, Amini Harandi, Ali, Olulana, Oluwaseyi, Chaudhary, Durgesh, Lyoubi, Aicha, Campbell, Bruce C.V., Arenillas, Juan F., Bock, Daniel, Montaner, Joan, Aghayari Sheikh Neshin, Saeideh, Aguiar de Sousa, Diana, Tenser, Matthew S., Aires, Ana, Alfonso, Mercedes de Lera, Alizada, Orkhan, Azevedo, Elsa, Goyal, Nitin, Babaeepour, Zabihollah, Banihashemi, Gelareh, Bonati, Leo H., Cereda, Carlo W., Chang, Jason J., Crnjakovic, Miljenko, De Marchis, Gian Marco, Del Sette, Massimo, Ebrahimzadeh, Seyed Amir, Farhoudi, Mehdi, Gandoglia, Ilaria, Gonçalves, Bruno, Griessenauer, Christoph J., Murat Hanci, Mehmet, Katsanos, Aristeidis H., Krogias, Christos, Leker, Ronen R., Lotman, Lev, Mai, Jeffrey, Male, Shailesh, Malhotra, Konark, Malojcic, Branko, Mesquita, Teresa, Mir Ghasemi, Asadollah, Mohamed Aref, Hany, Mohseni Afshar, Zeinab, Moon, Jusun, Niemelä, Mika, Rezai Jahromi, Behnam, Nolan, Lawrence, Pandhi, Abhi, Park, Jong-Ho, Marto, João Pedro, Purroy, Francisco, Ranji-Burachaloo, Sakineh, Carreira, Nuno Reis, Requena, Manuel, Rubiera, Marta, Sajedi, Seyed Aidin, Sargento-Freitas, João, Sharma, Vijay K., Steiner, Thorsten, Tempro, Kristi, Turc, Guillaume, Ahmadzadeh, Yasaman, Almasi-Dooghaee, Mostafa, Assarzadegan, Farhad, Babazadeh, Arefeh, Baharvahdat, Humain, Cardoso, Fabricio Buchadid, Dev, Apoorva, Ghorbani, Mohammad, Hamidi, Ava, Hasheminejad, Zeynab Sadat, Hojjat-Anasri Komachali, Sahar, Khorvash, Fariborz, Kobeissy, Firas, Mirkarimi, Hamidreza, Mohammadi-Vosough, Elahe, Misra, Debdipto, Noorian, Ali Reza, Nowrouzi-Sohrabi, Peyman, Paybast, Sepideh, Poorsaadat, Leila, Roozbeh, Mehrdad, Sabayan, Behnam, Salehizadeh, Saeideh, Saberi, Alia, Sepehrnia, Mercedeh, Vahabizad, Fahimeh, Yasuda, Thomas Alexandre, Ghabaee, Mojdeh, Rahimian, Nasrin, Harirchian, Mohammad Hossein, Borhani-Haghighi, Afshin, Azarpazhooh, Mahmoud Reza, Arora, Rohan, Ansari, Saeed, Avula, Venkatesh, Li, Jiang, Abedi, Vida, and Zand, Ramin
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Adult ,Male ,Risk ,Original Contributions ,International Cooperation ,intracranial hemorrhages ,Clinical and Population Sciences ,Sinus Thrombosis, Intracranial ,Young Adult ,Humans ,Prospective Studies ,Aged ,Ischemic Stroke ,Venous Thrombosis ,neuroimaging ,Geography ,COVID-19 ,cerebrovascular disorders ,Middle Aged ,stroke ,Treatment Outcome ,ComputingMethodologies_DOCUMENTANDTEXTPROCESSING ,Female ,Health Expenditures - Abstract
Supplemental Digital Content is available in the text., Background and Purpose: Stroke is reported as a consequence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in several reports. However, data are sparse regarding the details of these patients in a multinational and large scale. Methods: We conducted a multinational observational study on features of consecutive acute ischemic stroke, intracranial hemorrhage, and cerebral venous or sinus thrombosis among SARS-CoV-2–infected patients. We further investigated the risk of large vessel occlusion, stroke severity as measured by the National Institutes of Health Stroke Scale, and stroke subtype as measured by the TOAST (Trial of ORG 10172 in Acute Stroke Treatment) criteria among patients with acute ischemic stroke. In addition, we explored the neuroimaging findings, features of patients who were asymptomatic for SARS-CoV-2 infection at stroke onset, and the impact of geographic regions and countries’ health expenditure on outcomes. Results: Among the 136 tertiary centers of 32 countries who participated in this study, 71 centers from 17 countries had at least 1 eligible stroke patient. Of 432 patients included, 323 (74.8%) had acute ischemic stroke, 91 (21.1%) intracranial hemorrhage, and 18 (4.2%) cerebral venous or sinus thrombosis. A total of 183 (42.4%) patients were women, 104 (24.1%) patients were
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- 2021
31. Central Retinal Artery Occlusion: Current Practice, Awareness and Prehospital Delays in Switzerland
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Ardila Jurado, Elena, Sturm, Veit, Brugger, Florian, Nedeltchev, Krassen, Arnold, Marcel, Bonati, Leo H, Carrera, Emmanuel, Michel, Patrik, Cereda, Carlo W, Bolognese, Manuel, Albert, Sylvan, Medlin, Friedrich, Berger, Christian, Schelosky, Ludwig, Renaud, Susanne, Niederhauser, Julien, Bonvin, Christophe, Mono, Marie-Luise, Rodic, Biljana, Tarnutzer, Alexander A, Schwegler, Guido, Salmen, Stephan, Luft, Andreas R, Peters, Nils, Vehoff, Jochen, Kägi, Georg, Swiss Stroke Registry Investigators, University of Zurich, and Kägi, Georg
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awareness ,central retinal artery occlusion (CRAO) ,incidence ,ischemic stroke ,prehospital ,2728 Neurology (clinical) ,Neurology ,2808 Neurology ,610 Medicine & health ,Neurology (clinical) ,10040 Clinic for Neurology - Abstract
Background and PurposeCentral retinal artery occlusion (CRAO) often leads to permanent monocular blindness. Hence, early recognition and rapid re-perfusion is of paramount importance. This study aims to describe prehospital pathways in CRAO compared to stroke and study the knowledge about CRAO.Methods(1) Description of baseline characteristics, prehospital pathways/delays, and acute treatment (thrombolysis/thrombectomy vs. standard of care) of patients with CRAO and ischemic stroke registered in the Swiss Stroke Registry. (2) Online survey about CRAO knowledge amongst population, general practitioners (GPs) and ophthalmologists in Eastern Switzerland.ResultsThree hundred and ninety seven CRAO and 32,816 ischemic stroke cases were registered from 2014 until 2019 in 20 Stroke Centers/Units in Switzerland. In CRAO, 25.6% arrived at the hospital within 4 h of symptom onset and had a lower rate of emergency referrals. Hence, the symptom-to-door time was significantly longer in CRAO compared to stroke (852 min. vs. 300 min). The thrombolysis/thrombectomy rate was 13.2% in CRAO and 30.9% in stroke. 28.6% of the surveyed population recognized CRAO-symptoms, 55.4% of which would present directly to the emergency department in contrast to 90.0% with stroke symptoms. Almost 100% of the ophthalmologist and general practitioners recognized CRAO as a medical emergency and 1/3 of them considered IV thrombolysis a potentially beneficial therapy.ConclusionsCRAO awareness of the general population and physician awareness about the treatment options as well as the non-standardized prehospital organization, seems to be the main reason for the prehospital delays and impedes treating CRAO patients. Educational efforts should be undertaken to improve awareness about CRAO.
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- 2022
32. Association of the COVID‐19 Outbreak with Acute Stroke Care in Switzerland
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De Marchis, Gian Marco, Wright, Patrick R., Michel, Patrik, Strambo, Davide, Carrera, Emmanuel, Dirren, Elisabeth, Luft, Andreas R, Wegener, Susanne, Cereda, Carlo W, K��gi, Georg, Vehoff, Jochen, Gensicke, Henrik, Lyrer, Philippe, Nedeltchev, Krassen, Khales, Timo, Bolognese, Manuel, Salmen, Stephan, Sturzenegger, Rolf, Bonvin, Christophe, Berger, Christian, Schelosky, Ludwig, Mono, Marie���Luise, Rodic, Biljana, von Reding, Andrea, Schwegler, Guido, Tarnutzer, Alexander A., Medlin, Friedrich, Humm, Andrea M., Peters, Nils, Beyeler, Morin, Kriemler, Lilian, Bervini, David, Fandino, Javier, Hemkens, Lars G., Mordasini, Pasquale, Arnold, Marcel, Fischer, Urs, Bonati, Leo H., and Swiss Stroke Registry Investigators
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Stroke ,Neurology ,SARS-CoV-2 ,Communicable Disease Control ,COVID-19 ,Humans ,610 Medicine & health ,Neurology (clinical) ,Pandemics ,Retrospective Studies ,Stroke/epidemiology ,Stroke/therapy ,Switzerland/epidemiology ,epidemiology ,stroke ,610 Medizin und Gesundheit ,Switzerland - Abstract
In Switzerland, the COVID-19 incidence during the first pandemic wave was high. Our aim was to assess the association of the outbreak with acute stroke care in Switzerland in spring 2020. This was a retrospective analysis based on the Swiss Stroke Registry, which includes consecutive patients with acute cerebrovascular events admitted to Swiss Stroke Units and Stroke Centers. A linear model was fitted to the weekly admission from 2018 and 2019 and was used to quantify deviations from the expected weekly admissions from 13 March to 26 April 2020 (the "lockdown period"). Characteristics and 3-month outcome of patients admitted during the lockdown period were compared with patients admitted during the same calendar period of 2018 and 2019. In all, 28,310 patients admitted between 1 January 2018 and 26 April 2020 were included. Of these, 4491 (15.9%) were admitted in the periods March 13-April 26 of the years 2018-2020. During the lockdown in 2020, the weekly admissions dropped by up to 22% compared to rates expected from 2018 and 2019. During three consecutive weeks, weekly admissions fell below the 5% quantile (likelihood 0.38%). The proportion of intracerebral hemorrhage amongst all registered admissions increased from 7.1% to 9.3% (p = 0.006), and numerically less severe strokes were observed (median National Institutes of Health Stroke Scale from 3 to 2, p = 0.07). Admissions and clinical severity of acute cerebrovascular events decreased substantially during the lockdown in Switzerland. Delivery and quality of acute stroke care were maintained.
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- 2022
33. Risk factors, aetiology and outcome of ischaemic stroke in young adults: the Swiss Young Stroke Study (SYSS)
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Goeggel Simonetti, Barbara, Mono, Marie-Luise, Huynh-Do, Uyen, Michel, Patrik, Odier, Celine, Sztajzel, Roman, Lyrer, Philippe, Engelter, Stefan T., Bonati, Leo, Gensicke, Henrik, Traenka, Christopher, Tettenborn, Barbara, Weder, Bruno, Fischer, Urs, Galimanis, Aekaterini, Jung, Simon, Luedi, Rudolf, De Marchis, Gian Marco, Weck, Anja, Cereda, Carlo W., Baumgartner, Ralf, Bassetti, Claudio L., Mattle, Heinrich P., Nedeltchev, Krassen, and Arnold, Marcel
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- 2015
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34. Endovascular Treatment for Acute Ischemic Stroke With or Without General Anesthesia: A Matched Comparison
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Wagner, Benjamin, primary, Lorscheider, Johannes, additional, Wiencierz, Andrea, additional, Blackham, Kristine, additional, Psychogios, Marios, additional, Bolliger, Daniel, additional, De Marchis, Gian Marco, additional, Engelter, Stefan T., additional, Lyrer, Philippe, additional, Wright, Patrick R., additional, Fischer, Urs, additional, Mordasini, Pasquale, additional, Nannoni, Stefania, additional, Puccinelli, Francesco, additional, Kahles, Timo, additional, Bianco, Giovanni, additional, Carrera, Emmanuel, additional, Luft, Andreas R., additional, Cereda, Carlo W., additional, Kägi, Georg, additional, Weber, Johannes, additional, Nedeltchev, Krassen, additional, Michel, Patrik, additional, Gralla, Jan, additional, Arnold, Marcel, additional, Bonati, Leo H., additional, Anon, Javier, additional, Clarke, Sandra, additional, Diepers, Michael, additional, Gruber, Philipp, additional, Martin, Eileen, additional, Remonda, Luca, additional, Schweikert, Andreas, additional, Zupa., Vedrana, additional, Altersberger, Valerian, additional, Brehm, Alex, additional, Dittrich, Tolga, additional, El Mekabaty, Amgad, additional, Fladt, Joachim, additional, Fisch, Urs, additional, Gensicke, Henrik, additional, Hert, Lisa, additional, Manuzzi, Sabrina, additional, Maurer, Marina, additional, Meya, Louisa, additional, Peters, Nils, additional, Polymeris, Alexandros, additional, Thilemann, Sebastian, additional, Traenka, Christopher, additional, Tsogkas, Ioannes, additional, Zietz, Anaelle, additional, Goeldlin, Martina, additional, Heldner, Mirjam, additional, Jung, Simon, additional, Kaesmacher, Johannes, additional, Mamaari, Basel, additional, Meinel, Thomas, additional, Mueller, Madlaine, additional, Sarykaya, Hakan, additional, Seiffge, David, additional, Siepen, Bernhard, additional, Vynkier, Jan, additional, Eskandari, Ashraf, additional, Pantazou, Vasiliki, additional, Strambo, Davide, additional, Frangi, Jane, additional, Sihabdeen, Shairin, additional, Vehoff, Jochen, additional, Katan, Mira, additional, Mueller, Achim, additional, and Wegener, Susanne, additional
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- 2022
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35. Effect of admission time on provision of acute stroke treatment at stroke units and stroke centers—An analysis of the Swiss Stroke Registry
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Altersberger, Valerian L, primary, Wright, Patrick R, additional, Schaedelin, Sabine A, additional, De Marchis, Gian Marco, additional, Gensicke, Henrik, additional, Engelter, Stefan T, additional, Psychogios, Marios, additional, Kahles, Timo, additional, Goeldlin, Martina, additional, Meinel, Thomas R, additional, Mordasini, Pasquale, additional, Kaesmacher, Johannes, additional, von Hessling, Alexander, additional, Vehoff, Jochen, additional, Weber, Johannes, additional, Wegener, Susanne, additional, Salmen, Stephan, additional, Sturzenegger, Rolf, additional, Medlin, Friedrich, additional, Berger, Christian, additional, Schelosky, Ludwig, additional, Renaud, Susanne, additional, Niederhauser, Julien, additional, Bonvin, Christophe, additional, Schaerer, Michael, additional, Mono, Marie-Luise, additional, Rodic, Biljana, additional, Schwegler, Guido, additional, Peters, Nils, additional, Bolognese, Manuel, additional, Luft, Andreas R, additional, Cereda, Carlo W, additional, Kägi, Georg, additional, Michel, Patrick, additional, Carrera, Emmanuel, additional, Arnold, Marcel, additional, Fischer, Urs, additional, Nedeltchev, Krassen, additional, and Bonati, Leo H, additional
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- 2022
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36. Endovascular Treatment for Acute Ischemic Stroke With or Without General Anesthesia: A Matched Comparison
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Wagner, Benjamin, Lorscheider, Johannes, Wiencierz, Andrea, Blackham, Kristine, Psychogios, Marios, Bolliger, Daniel, De Marchis, Gian Marco, Engelter, Stefan T, Lyrer, Philippe, Wright, Patrick R, Fischer, Urs, Mordasini, Pasquale, Nannoni, Stefania, Puccinelli, Francesco, Kahles, Timo, Bianco, Giovanni, Carrera, Emmanuel, Luft, Andreas R, Cereda, Carlo W, Kägi, Georg, Weber, Johannes, Nedeltchev, Krassen, Michel, Patrik, Gralla, Jan, Arnold, Marcel, and Bonati, Leo H
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610 Medicine & health - Abstract
BACKGROUND Endovascular treatment in large artery occlusion stroke reduces disability. However, the impact of anesthesia type on clinical outcomes remains uncertain. METHODS We compared consecutive patients in the Swiss Stroke Registry with anterior circulation stroke receiving endovascular treatment with or without general anesthesia (GA). The primary outcome was disability on the modified Rankin Scale after 3 months, analyzed with ordered logistic regression. Secondary outcomes included dependency or death (modified Rankin Scale score ≥3), National Institutes of Health Stroke Scale after 24 hours, symptomatic intracranial hemorrhage with ≥4 points worsening on National Institutes of Health Stroke Scale within 7 days, and mortality. Coarsened exact matching and propensity score matching were performed to adjust for indication bias. RESULTS One thousand two hundred eighty-four patients (GA: n=851, non-GA: n=433) from 8 Stroke Centers were included. Patients treated with GA had higher modified Rankin Scale scores after 3 months than patients treated without GA, in the unmatched (odds ratio [OR], 1.75 [1.42-2.16]; P
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- 2022
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37. sj-docx-1-eso-10.1177_23969873221094408 – Supplemental material for Effect of admission time on provision of acute stroke treatment at stroke units and stroke centers—An analysis of the Swiss Stroke Registry
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Altersberger, Valerian L, Wright, Patrick R, Schaedelin, Sabine A, De Marchis, Gian Marco, Gensicke, Henrik, Engelter, Stefan T, Psychogios, Marios, Kahles, Timo, Goeldlin, Martina, Meinel, Thomas R, Mordasini, Pasquale, Kaesmacher, Johannes, von Hessling, Alexander, Vehoff, Jochen, Weber, Johannes, Wegener, Susanne, Salmen, Stephan, Sturzenegger, Rolf, Medlin, Friedrich, Berger, Christian, Schelosky, Ludwig, Renaud, Susanne, Niederhauser, Julien, Bonvin, Christophe, Schaerer, Michael, Mono, Marie-Luise, Rodic, Biljana, Schwegler, Guido, Peters, Nils, Bolognese, Manuel, Luft, Andreas R, Cereda, Carlo W, Kägi, Georg, Michel, Patrick, Carrera, Emmanuel, Arnold, Marcel, Fischer, Urs, Nedeltchev, Krassen, and Bonati, Leo H
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FOS: Clinical medicine ,Cardiology ,Medicine ,110904 Neurology and Neuromuscular Diseases - Abstract
Supplemental material, sj-docx-1-eso-10.1177_23969873221094408 for Effect of admission time on provision of acute stroke treatment at stroke units and stroke centers—An analysis of the Swiss Stroke Registry by Valerian L Altersberger, Patrick R Wright, Sabine A Schaedelin, Gian Marco De Marchis, Henrik Gensicke, Stefan T Engelter, Marios Psychogios, Timo Kahles, Martina Goeldlin, Thomas R Meinel, Pasquale Mordasini, Johannes Kaesmacher, Alexander von Hessling, Jochen Vehoff, Johannes Weber, Susanne Wegener, Stephan Salmen, Rolf Sturzenegger, Friedrich Medlin, Christian Berger, Ludwig Schelosky, Susanne Renaud, Julien Niederhauser, Christophe Bonvin, Michael Schaerer, Marie-Luise Mono, Biljana Rodic, Guido Schwegler, Nils Peters, Manuel Bolognese, Andreas R Luft, Carlo W Cereda, Georg Kägi, Patrick Michel, Emmanuel Carrera, Marcel Arnold, Urs Fischer, Krassen Nedeltchev and Leo H Bonati in European Stroke Journal
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- 2022
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38. Early versus late start of direct oral anticoagulants after acute ischaemic stroke linked to atrial fibrillation: an observational study and individual patient data pooled analysis
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De Marchis, Gian Marco Seiffge, David J. Schaedelin, Sabine and Wilson, Duncan Caso, Valeria Acciarresi, Monica Tsivgoulis, Georgios Koga, Masatoshi Yoshimura, Sohei Toyoda, Kazunori and Cappellari, Manuel Bonetti, Bruno Macha, Kosmas and Kallmuenzer, Bernd Cereda, Carlo W. Lyrer, Philippe Bonati, Leo H. Paciaroni, Maurizio Engelter, Stefan T. Werring, David J.
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cardiovascular diseases - Abstract
Objective The optimal timing to start direct oral anticoagulants (DOACs) after an acute ischaemic stroke (AIS) related to atrial fibrillation (AF) remains unclear. We aimed to compare early (5 days of AIS) DOAC-start. Methods This is an individual patient data pooled analysis of eight prospective European and Japanese cohort studies. We included patients with AIS related to non-valvular AF where a DOAC was started within 30 days. Primary endpoints were 30-day rates of recurrent AIS and ICH. Results A total of 2550 patients were included. DOACs were started early in 1362 (53%) patients, late in 1188 (47%). During 212 patient-years, 37 patients had a recurrent AIS (1.5%), 16 (43%) before a DOAC was started; 6 patients (0.2%) had an ICH, all after DOAC-start. In the early DOAC-start group, 23 patients (1.7%) suffered from a recurrent AIS, while 2 patients (0.1%) had an ICH. In the late DOAC-start group, 14 patients (1.2%) suffered from a recurrent AIS; 4 patients (0.3%) suffered from ICH. In the propensity score-adjusted comparison of late versus early DOAC-start groups, there was no statistically significant difference in the hazard of recurrent AIS (aHR=1.2, 95% CI 0.5 to 2.9, p=0.69), ICH (aHR=6.0, 95% CI 0.6 to 56.3, p=0.12) or any stroke. Conclusions Our results do not corroborate concerns that an early DOAC-start might excessively increase the risk of ICH. The sevenfold higher risk of recurrent AIS than ICH suggests that an early DOAC-start might be reasonable, supporting enrolment into randomised trials comparing an early versus late DOAC-start.
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- 2022
39. Safety and Outcome of Revascularization Treatment in Patients With Acute Ischemic Stroke and COVID-19: The Global COVID-19 Stroke Registry
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Marto, João Pedro, Strambo, Davide, Ntaios, George, Nguyen, Thanh N, Herzig, Roman, Czlonkowska, Anna, Demeestere, Jelle, Mansour, Ossama Yassin, Salerno, Alexander, Wegener, Susanne, Baumgartner, Philipp, Cereda, Carlo W, Bianco, Giovanni, Beyeler, Morin, Arnold, Marcel, Carrera, Emmanuel, Machi, Paolo, Altersberger, Valerian, Bonati, Leo, Gensicke, Henrik, Bolognese, Manuel, Peters, Nils, Wetzel, Stephan, Magriço, Marta, Ramos, João Nuno, Sargento-Freitas, João, Machado, Rita, Maia, Carolina, Machado, Egídio, Nunes, Ana Paiva, Ferreira, Patricia, Pinho E Melo, Teresa, Dias, Mariana Carvalho, Paula, André, Correia, Manuel Alberto, Castro, Pedro, Azevedo, Elsa, Albuquerque, Luís, Alves, José Nuno, Ferreira-Pinto, Joana, Meira, Torcato, Pereira, Liliana, Rodrigues, Miguel, Araujo, Andre Pinho, Rodrigues, Marta, Rocha, Mariana, Pereira-Fonseca, Ângelo, Ribeiro, Luís, Varela, Ricardo, Malheiro, Sofia, Cappellari, Manuel, Zivelonghi, Cecilia, Sajeva, Giulia, Zini, Andrea, Gentile, Mauro, Forlivesi, Stefano, Migliaccio, Ludovica, Sessa, Maria, La Gioia, Sara, Pezzini, Alessandro, Sangalli, Davide, Zedde, Marialuisa, Pascarella, Rosario, Ferrarese, Carlo, Beretta, Simone, Diamanti, Susanna, Schwarz, Ghil, Frisullo, Giovanni, Marcheselli, Simona, Seners, Pierre, Sabben, Candice, Escalard, Simon, Piotin, Michel, Maïer, Benjamin, Charbonnier, Guillaume, Vuillier, Fabrice, Legris, Loïc, Cuisenier, Pauline, Vodret, Francesca R, Marnat, Gaultier, Liegey, Jean-Sebastien, Sibon, Igor, Flottmann, Fabian, Broocks, Gabriel, Gloyer, Nils-Ole, Bohmann, Ferdinand O, Schaefer, Jan Hendrik, Nolte, Christian, Audebert, Heinrich J, Siebert, Eberhard, Sykora, Marek, Lang, Wilfried, Ferrari, Julia, Mayer-Suess, Lukas, Knoflach, Michael, Gizewski, Elke Ruth, Stolp, Jeffrey, Stolze, Lotte J, Coutinho, Jonathan M, Nederkoorn, Paul, van den Wijngaard, Ido, De Meris, Joke, Lemmens, Robin, De Raedt, Sylvie, Vandervorst, Fenne, Rutgers, Matthieu Pierre, Guilmot, Antoine, Dusart, Anne, Bellante, Flavio, Calleja-Castaño, Patricia, Ostos, Fernando, González-Ortega, Guillermo, Martín-Jiménez, Paloma, García-Madrona, Sebastian, Cruz-Culebras, Antonio, Vera, Rocio, Matute, Maria Consuelo, Fuentes, Blanca, Alonso-de-Leciñana, María, Rigual, Ricardo, Díez-Tejedor, Exuperio, Perez-Sanchez, Soledad, Montaner, Joan, Díaz-Otero, Fernando, Pérez-de-la-Ossa, Natalia, Flores-Pina, Belén, Muñoz-Narbona, Lucia, Chamorro, Angel, Rodríguez-Vázquez, Alejandro, Renú, Arturo, Ayo-Martin, Oscar, Hernández-Fernández, Francisco, Segura, Tomas, Tejada-Meza, Herbert, Sagarra-Mur, Daniel, Serrano-Ponz, Marta, Hlaing, Thant, See, Isaiah, Simister, Robert, Werring, David, Kristoffersen, Espen Saxhaug, Nordanstig, Annika, Jood, Katarina, Rentzos, Alexandros, Šimůnek, Libor, Krajíčková, Dagmar, Krajina, Antonín, Mikulik, Robert, Cviková, Martina, Vinklárek, Jan, Školoudík, David, Roubec, Martin, Hurtikova, Eva, Hrubý, Rostislav, Ostry, Svatopluk, Skoda, Ondrej, Pernicka, Marek, Jurak, Lubomir, Eichlová, Zuzana, Jíra, Martin, Kovar, Martin, Panský, Michal, Mencl, Pavel, Palouskova, Hana, Tomek, Aleš, Janský, Petr, Olšerová, Anna, Sramek, Martin, Havlicek, Roman, Malý, Petr, Trakal, Lukáš, Fiksa, Jan, Slovák, Matěj, Karlinski, Michal Adam, Nowak, Maciej, Sienkiewicz-Jarosz, Halina, Bochynska, Anna, Wrona, Pawel, Homa, Tomasz, Sawczynska, Katarzyna, Slowik, Agnieszka, Wlodarczyk, Ewa, Wiacek, Marcin, Tomaszewska-Lampart, Izabella, Sieczkowski, Bartosz, Bartosik-Psujek, Halina, Bilik, Marta, Bandzarewicz, Anna, Dorobek, Malgorzata, Zielinska-Turek, Justyna, Nowakowska-Kotas, Marta, Obara, Krystian, Urbanowski, Paweł, Budrewicz, Slawomir, Guziński, Maciej, Świtońska, Milena, Rutkowska, Iwona, Sobieszak-Skura, Paulina, Labuz-Roszak, Beata M, Debiec, Aleksander, Staszewski, Jacek, Stępień, Adam, Zwiernik, Jacek, Wasilewski, Grzegorz, Tiu, Cristina, Terecoasă, Elena Oana, Radu, Razvan Alexandru, Negrila, Anca, Dorobat, Bogdan, Panea, Cristina, Tiu, Vlad, Petrescu, Simona, Ozdemir, Atilla, Mahmoud, Mostafa, El-Samahy, Hussam, Abdelkhalek, Hazem, Al-Hashel, Jasem, Ismail, Ismail Ibrahim, Salmeen, Athari, Ghoreishi, Abdoreza, Sabetay, Sergiu Ionut, Gross, Hana, Klein, Piers, Abdalkader, Mohamad, Jabbour, Pascal, El Naamani, Kareem, Tjoumakaris, Stavropoula, Abbas, Rawad, Mohamed, Ghada A, Chebl, Alex, Min, Jiangyong, Hovingh, Majesta, Tsai, Jenney P, Khan, Muhib, Nalleballe, Krishna, Onteddu, Sanjeeva, Masoud, Hesham, Michael, Mina, Kaur, Navreet, Maali, Laith, Abraham, Michael G, Khandelwal, Priyank, Bach, Ivo, Ong, Melody, Babici, Denis, Khawaja, Ayaz M, Hakemi, Maryam, Rajamani, Kumar, Cano-Nigenda, Vanessa, Arauz, Antonio, Amaya, Pablo, Llanos, Natalia, Arango, Akemi, Vences, Miguel Ángel, Barrientos Guerra, Jose Dominguo, Caetano, Rayllene, Martins, Rodrigo Targa, Scollo, Sergio Daniel, Yalung, Patrick Matic, Nagendra, Shashank, Gaikwad, Abhijit, Seo, Kwon-Duk, Georgiopoulos, Georgios, Nogueira, Raul G, Michel, Patrik, Neurology, Clinical sciences, Neuroprotection & Neuromodulation, Faculty of Medicine and Pharmacy, Biology, and Brussels Heritage Lab
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Fibrinolytic Agents/therapeutic use ,Cerebral Hemorrhage/complications ,Stroke/epidemiology ,Brain Ischemia/complications ,Treatment Outcome ,Ischemic Stroke/epidemiology ,COVID-19/complications ,Humans ,Cohort studies ,Endovascular Procedures/adverse effects ,Registries ,Neurology (clinical) ,610 Medicine & health ,Intracranial Hemorrhages/etiology ,Thrombolytic Therapy/adverse effects ,Research Article - Abstract
Background and ObjectivesCOVID-19–related inflammation, endothelial dysfunction, and coagulopathy may increase the bleeding risk and lower the efficacy of revascularization treatments in patients with acute ischemic stroke (AIS). We aimed to evaluate the safety and outcomes of revascularization treatments in patients with AIS and COVID-19.MethodsThis was a retrospective multicenter cohort study of consecutive patients with AIS receiving intravenous thrombolysis (IVT) and/or endovascular treatment (EVT) between March 2020 and June 2021 tested for severe acute respiratory syndrome coronavirus 2 infection. With a doubly robust model combining propensity score weighting and multivariate regression, we studied the association of COVID-19 with intracranial bleeding complications and clinical outcomes. Subgroup analyses were performed according to treatment groups (IVT-only and EVT).ResultsOf a total of 15,128 included patients from 105 centers, 853 (5.6%) were diagnosed with COVID-19; of those, 5,848 (38.7%) patients received IVT-only and 9,280 (61.3%) EVT (with or without IVT). Patients with COVID-19 had a higher rate of symptomatic intracerebral hemorrhage (SICH) (adjusted OR 1.53; 95% CI 1.16–2.01), symptomatic subarachnoid hemorrhage (SSAH) (OR 1.80; 95% CI 1.20–2.69), SICH and/or SSAH combined (OR 1.56; 95% CI 1.23–1.99), 24-hour mortality (OR 2.47; 95% CI 1.58–3.86), and 3-month mortality (OR 1.88; 95% CI 1.52–2.33). Patients with COVID-19 also had an unfavorable shift in the distribution of the modified Rankin score at 3 months (OR 1.42; 95% CI 1.26–1.60).DiscussionPatients with AIS and COVID-19 showed higher rates of intracranial bleeding complications and worse clinical outcomes after revascularization treatments than contemporaneous non–COVID-19 patients receiving treatment. Current available data do not allow direct conclusions to be drawn on the effectiveness of revascularization treatments in patients with COVID-19 or to establish different treatment recommendations in this subgroup of patients with ischemic stroke. Our findings can be taken into consideration for treatment decisions, patient monitoring, and establishing prognosis.Trial Registration InformationThe study was registered under ClinicalTrials.gov identifierNCT04895462.
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- 2022
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40. A benchmarking tool to evaluate computer tomography perfusion infarct core predictions against a DWI standard
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Cereda, Carlo W, Christensen, Søren, Campbell, Bruce CV, Mishra, Nishant K, Mlynash, Michael, Levi, Christopher, Straka, Matus, Wintermark, Max, Bammer, Roland, Albers, Gregory W, Parsons, Mark W, and Lansberg, Maarten G
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- 2016
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41. Safety and Outcome of Revascularization Treatment in Patients With Acute Ischemic Stroke and COVID-19: The Global COVID-19 Stroke Registry.
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Marto, João Pedro, Strambo, Davide, Ntaios, George, Nguyen, Thanh N., Herzig, Roman, Czlonkowska, Anna, Demeestere, Jelle, Mansour, Ossama Yassin, Salerno, Alexander, Wegener, Susanne, Baumgartner, Philipp, Cereda, Carlo W., Bianco, Giovanni, Beyeler, Morin, Arnold, Marcel, Carrera, Emmanuel, Machi, Paolo, Altersberger, Valerian, Bonati, Leo, and Gensicke, Henrik
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- 2023
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42. Intravenous Thrombolysis in Patients With Ischemic Stroke Aged ≥90 Years: A Cohort Study From the TRISP Collaboration.
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Altersberger, Valerian L., Rusche, Norman, Martinez-Majander, Nicolas, Hametner, Christian, Scheitz, Jan F., Henon, Hilde, Dell'Acqua, Maria Luisa, Strambo, Davide, Stolp, Jeffrey, Heldner, Mirjam R., Grisendi, Ilaria, Jovanovic, Dejana R., Bejot, Yannick, Pezzini, Alessandro, Leker, Ronen R., Kägi, Georg, Wegener, Susanne, Cereda, Carlo W., Lindgren, Erik, and Ntaios, George
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- 2022
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43. ANA Investigates: Basilar Artery Stroke
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Johansen, Michelle C., primary, Cereda, Carlo W., additional, and Heit, Jeremy J., additional
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- 2022
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44. Abstract 126: Cerebral Perfusion Imaging And Posterior Circulation ASPECTS Identify Stroke Patients Who Benefit From Basilar Artery Thrombectomy
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Heit, Jeremy J, primary, Bianco, Giovanni, additional, Mlynash, Michael, additional, Yuen, Nicole, additional, Qureshi, Abid Y, additional, Hinduja, Archana, additional, Dehkharghani, Seena, additional, Goldman-Yassen, Adam, additional, Hsieh, Kevin Li-Chun, additional, Giurgiutiu, Dan-victor, additional, Gibson, Daniel, additional, Carrera, Emmanuel, additional, Alemseged, Fana, additional, Faizy, Tobias D, additional, Fiehler, Jens, additional, Pileggi, Marco, additional, Lansberg, Maarten G, additional, Campbell, Bruce, additional, Albers, Gregory W, additional, and Cereda, Carlo W, additional
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- 2022
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45. Abstract WP75: Sex Differences In The Outcomes Of Intravenous Thrombolysis In Acute Ischemic Stroke Patients With Preadmission Use Of Antiplatelet Agents: A Population-based Study In The Swiss Stroke Registry
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Noseda, Roberta, primary, Rea, Federico, additional, Pagnamenta, Alberto, additional, Bianco, Giovanni, additional, Sihabdeen, Shairin, additional, agazzi, pamela, additional, Seiffge, David, additional, Michel, Patrik, additional, Nedeltchev, Krassen, additional, Bonati, Leo, additional, Kägi, Georg, additional, Niederhauser, Julien, additional, Nyffeler, Thomas, additional, Luft, Andreas, additional, Schelosky, Ludwig, additional, Medlin, Friedrich, additional, Rodic, Biljana, additional, Peters, Nils, additional, Renaud, Susanne, additional, Mono, Marie-Luise, additional, Carrera, Emmanuel, additional, Fischer, Urs, additional, Ceschi, Professor Alessandro, additional, and Cereda, Carlo W, additional
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- 2022
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46. Perfusion Imaging Predicts Favorable Outcomes after Basilar Artery Thrombectomy
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Cereda, Carlo W., primary, Bianco, Giovanni, additional, Mlynash, Michael, additional, Yuen, Nicole, additional, Qureshi, Abid Y., additional, Hinduja, Archana, additional, Dehkharghani, Seena, additional, Goldman‐Yassen, Adam E., additional, Hsieh, Kevin Li‐Chun, additional, Giurgiutiu, Dan‐Victor, additional, Gibson, Dan, additional, Carrera, Emmanuel, additional, Alemseged, Fana, additional, Faizy, Tobias D., additional, Fiehler, Jens, additional, Pileggi, Marco, additional, Campbell, Bruce, additional, Albers, Gregory W., additional, and Heit, Jeremy J., additional
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- 2021
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47. Measurement of Midregional Pro-Atrial Natriuretic Peptide to Discover Atrial Fibrillation in Patients With Ischemic Stroke
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Schweizer, Juliane, Arnold, Markus, König, Inke R, Bicvic, Antonela, Westphal, Laura P, Schütz, Valerie, Inauen, Corinne, Scherrer, Natalie, Luft, Andreas, Galovic, Marian, Ferreira Atuesta, Carolina, Pokorny, Thomas, Arnold, Marcel, Fischer, Urs, Bonati, Leo H, De Marchis, Gian Marco, Kahles, Timo, Nedeltchev, Krassen, Cereda, Carlo W, Kägi, Georg, Bustamante, Alejandro, Montaner, Joan, Ntaios, Georg, Sagris, Dimitrios, Foerch, Christian, Spanaus, Katharina, von Eckardstein, Arnold, Katan, Mira, University of Zurich, Arnold, Markus, Arnold, Marcel, Swiss National Science Foundation, Swiss Heart Foundation, and Baasch Medicus Foundation
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610 Medicine & health ,Biomarker ,Midregional pro-atrial natriuretic peptide ,Risk Assessment ,Risk prediction ,2705 Cardiology and Cardiovascular Medicine ,10040 Clinic for Neurology ,Cohort Studies ,540 Chemistry ,Atrial Fibrillation ,Humans ,Cardiology and Cardiovascular Medicine ,Atrial Natriuretic Factor ,Biomarkers ,Stroke etiology ,10038 Institute of Clinical Chemistry ,Ischemic Stroke - Abstract
[Background] Midregional pro-atrial natriuretic peptide (MR-proANP) is a promising biomarker to differentiate the underlying etiology of acute ischemic stroke (AIS)., [Objectives] This study aimed to determine the role of MR-proANP for classification as cardioembolic (CE) stroke, identification of newly diagnosed atrial fibrillation (NDAF), and risk assessment for major adverse cardiovascular events (MACE)., [Methods] This study measured MR-proANP prospectively collected within 24 hours after symptom-onset in patients with AIS from the multicenter BIOSIGNAL (Biomarker Signature of Stroke Aetiology) cohort study. Primary outcomes were CE stroke etiology and NDAF after prolonged cardiac monitoring, as well as a composite outcome of MACE (recurrent cerebrovascular events, myocardial infarction, or cardiovascular death) within 1 year. Logistic/Poisson and subproportional hazard regression were applied to evaluate the association between MR-proANP levels and outcomes. Additionally, a model for prediction of NDAF was derived and validated as a decision tool for immediate clinical application., [Results] Between October 1, 2014, and October 31, 2017, this study recruited 1,759 patients. Log10MR-proANP levels were associated with CE stroke (OR: 7.96; 95% CI: 4.82-13.14; risk ratio: 3.12; 95% CI: 2.23-4.37), as well as NDAF (OR: 35.3; 95% CI: 17.58-71.03; risk ratio: 11.47; 95% CI: 6.74-19.53), and MACE (subdistributional HR: 2.02; 95% CI: 1.32-3.08) during follow-up. The model to predict NDAF including only age and MR-proANP levels had a good discriminatory capacity with an area under the curve of 0.81 (95% CI: 0.76-0.86), was well calibrated (calibration in the large: −0.086; calibration slope 1.053), and yielded higher net-benefit compared with validated scores to predict NDAF (AS5F score, CHA2DS2-VASc [Congestive Heart Failure, Hypertension, Age ≥65 or ≥75, Diabetes, Prior Cardioembolic Event, (female) Sex, or Vascular Disease] score)., [Conclusions] MR-proANP is a valid biomarker to determine risk of NDAF and MACE in patients with AIS and can be used as a decision tool to identify patients for prolonged cardiac monitoring. (Biomarker Signature of Stroke Aetiology Study: The BIOSIGNAL study [BIOSIGNAL]; NCT02274727), This study was supported by the Swiss National Science Foundation (grant 142422), the Swiss Heart Foundation, and the Baasch Medicus Foundation.
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- 2021
48. Early versus late start of direct oral anticoagulants after acute ischaemic stroke linked to atrial fibrillation: an observational study and individual patient data pooled analysis
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De Marchis, Gian Marco, primary, Seiffge, David J., additional, Schaedelin, Sabine, additional, Wilson, Duncan, additional, Caso, Valeria, additional, Acciarresi, Monica, additional, Tsivgoulis, Georgios, additional, Koga, Masatoshi, additional, Yoshimura, Sohei, additional, Toyoda, Kazunori, additional, Cappellari, Manuel, additional, Bonetti, Bruno, additional, Macha, Kosmas, additional, Kallmünzer, Bernd, additional, Cereda, Carlo W., additional, Lyrer, Philippe, additional, Bonati, Leo H., additional, Paciaroni, Maurizio, additional, Engelter, Stefan T., additional, and Werring, David J., additional
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- 2021
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49. Etiology, 3-Month Functional Outcome and Recurrent Events in Non-Traumatic Intracerebral Hemorrhage
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Goeldlin, Martina B, Mueller, Achim, Siepen, Bernhard M, Mueller, Madlaine, Strambo, Davide, Michel, Patrik, Schaerer, Michael, Cereda, Carlo W, Bianco, Giovanni, Lindheimer, Florian, Berger, Christian, Medlin, Friedrich, Backhaus, Roland, Peters, Nils, Renaud, Susanne, Fisch, Loraine, Niederhaeuser, Julien, Carrera, Emmanuel, Dirren, Elisabeth, Bonvin, Christophe, Sturzenegger, Rolf, Kahles, Timo, Nedeltchev, Krassen, Kaegi, Georg, Vehoff, Jochen, Rodic, Biljana, Bolognese, Manuel, Schelosky, Ludwig, Salmen, Stephan, Mono, Marie-Luise, Polymeris, Alexandros A, Engelter, Stefan T, Lyrer, Philippe, Wegener, Susanne, Luft, Andreas R, Z'Graggen, Werner, Bervini, David, Volbers, Bastian, Dobrocky, Tomas, Kaesmacher, Johannes, Mordasini, Pasquale, Meinel, Thomas R, Arnold, Marcel, Fandino, Javier, Bonati, Leo H, Fischer, Urs, Seiffge, David J, and SSR Investigators
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Cerebral hemorrhage ,Etiology ,Ischemic stroke ,Outcome ,610 Medicine & health ,Neurology (clinical) ,cardiovascular diseases ,Cardiology and Cardiovascular Medicine - Abstract
BACKGROUND AND PURPOSE Knowledge about different etiologies of non-traumatic intracerebral hemorrhage (ICH) and their outcomes is scarce. METHODS We assessed prevalence of pre-specified ICH etiologies and their association with outcomes in consecutive ICH patients enrolled in the prospective Swiss Stroke Registry (2014 to 2019). RESULTS We included 2,650 patients (mean±standard deviation age 72±14 years, 46.5% female, median National Institutes of Health Stroke Scale 8 [interquartile range, 3 to 15]). Etiology was as follows: hypertension, 1,238 (46.7%); unknown, 566 (21.4%); antithrombotic therapy, 227 (8.6%); cerebral amyloid angiopathy (CAA), 217 (8.2%); macrovascular cause, 128 (4.8%); other determined etiology, 274 patients (10.3%). At 3 months, 880 patients (33.2%) were functionally independent and 664 had died (25.1%). ICH due to hypertension had a higher odds of functional independence (adjusted odds ratio [aOR], 1.33; 95% confidence interval [CI], 1.00 to 1.77; P=0.05) and lower mortality (aOR, 0.64; 95% CI, 0.47 to 0.86; P=0.003). ICH due to antithrombotic therapy had higher mortality (aOR, 1.62; 95% CI, 1.01 to 2.61; P=0.045). Within 3 months, 4.2% of patients had cerebrovascular events. The rate of ischemic stroke was higher than that of recurrent ICH in all etiologies but CAA and unknown etiology. CAA had high odds of recurrent ICH (aOR, 3.38; 95% CI, 1.48 to 7.69; P=0.004) while the odds was lower in ICH due to hypertension (aOR, 0.42; 95% CI, 0.19 to 0.93; P=0.031). CONCLUSIONS Although hypertension is the leading etiology of ICH, other etiologies are frequent. One-third of ICH patients are functionally independent at 3 months. Except for patients with presumed CAA, the risk of ischemic stroke within 3 months of ICH was higher than the risk of recurrent hemorrhage.
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- 2021
50. Obstructive and Central Sleep Apnea in First Ever Ischemic Stroke are Associated with Different Time Course and Autonomic Activation
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Riglietti, Alessia, primary, Fanfulla, Francesco, additional, Pagani, Massimo, additional, Lucini, Daniela, additional, Malacarne, Mara, additional, Manconi, Mauro, additional, Ferretti, Guido, additional, Esposito, Fabio, additional, Cereda, Carlo W, additional, and Pons, Marco, additional
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- 2021
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