29 results on '"Ceruti D"'
Search Results
2. Prescriptive appropriateness in primary cardiovascular prevention: Data from Niguarda hospital
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Maloberti, A., Ceruti, D., Gualini, E., Colombo, V., Giani, V., Milani, M., Sun, J., Alloni, M., and Giannattasio, C.
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- 2022
- Full Text
- View/download PDF
3. Prescriptive Appropriateness in Primary Cardiovascular Prevention: Data from Niguarda Hospital
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Maloberti, A, Ceruti, D, Gualini, E, Colombo, V, Giani, V, Milani, M, Sun, J, Alloni, M, Giannattasio, C, Maloberti, Alessandro, Ceruti, Davide, Gualini, Elena, Colombo, Valentina, Giani, Valentina, Milani, Martina, Sun, Jinwei, Alloni, Marta, Giannattasio, Cristina, Maloberti, A, Ceruti, D, Gualini, E, Colombo, V, Giani, V, Milani, M, Sun, J, Alloni, M, Giannattasio, C, Maloberti, Alessandro, Ceruti, Davide, Gualini, Elena, Colombo, Valentina, Giani, Valentina, Milani, Martina, Sun, Jinwei, Alloni, Marta, and Giannattasio, Cristina
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- 2022
4. P348 PRESCRIPTIVE APPROPRIATENESS IN PRIMARY CARDIOVASCULAR PREVENTION: DATA FROM NIGUARDA HOSPITAL
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Maloberti, A, primary, Ceruti, D, additional, Gualini, E, additional, Colombo, V, additional, Giani, V, additional, Milani, M, additional, Sun, J, additional, Alloni, M, additional, and Giannattasio, C, additional
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- 2022
- Full Text
- View/download PDF
5. Educación en niños asmáticos controlados en hospital Roberto del Río: Impacto en conocimientos, adherencia y control de la enfermedad
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Henríquez Y, María Teresita and Ceruti D, Eliana
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Asthma education ,asma pediátrica ,Educación en asma ,pediatric asthma - Abstract
Introducción: El objetivo fue optimizar los conocimientos, técnica inhalatoria, adherencia y el control del asma, mediante un taller de educación. Métodos: Se enrolaron pacientes asmáticos (edad: entre 5 y 14 años), con cuestionario CAN (Control del Asma en Niños). Los pacientes con puntaje mayor o igual a 8, se invitaron a un taller de educación, se evaluó conocimientos, técnica inhalatoria y se realizó una clase sobre asma. A los 6 meses, se reevaluaron con cuestionario CAN, prueba de conocimientos y técnica inhalatoria. Resultados: Se reclutaron 91 pacientes con CAN mayor o igual a 8, de los cuales asistieron 49 al taller. En la segunda etapa asistieron 40 pacientes. En el 52,5% de los pacientes, se logró puntaje CAN menor a 8 puntos. Se excluyeron 2 pacientes, por modificación del tratamiento, como resultado final 47,5 % de los pacientes, disminuyó su puntaje CAN a menos de 8. Conclusiones: La educación mejoró conocimientos, técnica inhalatoria y adherencia. Se deberían implementar talleres educativos en nuestra práctica clínica. Introduction: Today is clear the role of educational programs in the control of chronic diseases. The goal was optimize the knowledge, adhesion, inhalation technique and asthma control through an educational workshop. Methods: We enrolled asthmatic patients (age 5 to 14 years), with questionnaire "control of asthma in children " (CAN). Patients with an score greater than or equal to 8 were invited to the educational workshop with a class of asthma, after a evaluation of knowledge and inhalation technique. These patients were reevaluated 6 months later. Results: 91 patients were recruited with a CAN score greater than or equal to 8, only 49 attended the workshop and 40 attended the reevaluation. Of these, 52,5% of the patients achieved a CAN score less than 8. Two patients were excluded because of modification of treatment, resulting in 47,5% of patients with CAN score less than 8. Conclusion: The education improved the knowledge, inhalation technique and adherence. Educational workshop should be implemented in our clinical practice.
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- 2013
6. Educación en niños asmáticos controlados en hospital Roberto del Río: Impacto en conocimientos, adherencia y control de la enfermedad
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María Teresita Henríquez Y and Eliana Ceruti D
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asma pediátrica ,General Medicine ,Educación en asma - Abstract
Introduccion: El objetivo fue optimizar los conocimientos, tecnica inhalatoria, adherencia y el control del asma, mediante un taller de educacion. Metodos: Se enrolaron pacientes asmaticos (edad: entre 5 y 14 anos), con cuestionario CAN (Control del Asma en Ninos). Los pacientes con puntaje mayor o igual a 8, se invitaron a un taller de educacion, se evaluo conocimientos, tecnica inhalatoria y se realizo una clase sobre asma. A los 6 meses, se reevaluaron con cuestionario CAN, prueba de conocimientos y tecnica inhalatoria. Resultados: Se reclutaron 91 pacientes con CAN mayor o igual a 8, de los cuales asistieron 49 al taller. En la segunda etapa asistieron 40 pacientes. En el 52,5% de los pacientes, se logro puntaje CAN menor a 8 puntos. Se excluyeron 2 pacientes, por modificacion del tratamiento, como resultado final 47,5 % de los pacientes, disminuyo su puntaje CAN a menos de 8. Conclusiones: La educacion mejoro conocimientos, tecnica inhalatoria y adherencia. Se deberian implementar talleres educativos en nuestra practica clinica.
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- 2013
7. Impacto del sobrepeso y la obesidad en el asma infantil
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Vidal G, Alberto, Escobar C, Ana María, Ceruti D, Eliana, Henríquez Y, María Teresita, and Medina R, María Eugenia
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función pulmonar ,obese ,sobrepeso ,Asthma control ,overweight ,lung function ,Control de asma ,obesidad - Abstract
Introducción: La evidencia sugiere que el sobrepeso y la obesidad alterarían el control y la función pulmonar de los niños asmáticos. Objetivo: Medir el impacto del sobrepeso y obesidad en el control y función pulmonar de una población de niños asmáticos persistentes. Material y Método: Se realizó evaluación nutricional, medición de control de asma y espirometría a niños asmáticos persistentes entre 5 y 15 anos, controlados en una Unidad de Enfermedades Respiratorias. Se determinó la presencia de síntomas de asma, los parámetros que permiten precisar su adecuado manejo y algunos factores predisponentes según estado nutricional. Las diferencias entre grupos se evaluaron a través del chi cuadrado de Mantel-Haenszel y el de tendencia, considerándose significativos valores de p < 0,05. Resultados: Se estudiaron a 219 niños, sexo masculino 60,3%, promedio de edad de 8,5 anos. La frecuencia de sobrepeso y obesidad alcanzó el 63,5%. Asmáticos eutróficos 36,5%, con sobrepeso 30,6% y obesos 32,9%. Asma no controlada (eutróficos 37,5%, con sobrepeso y obesidad 65,5%, p = 0,0001), espirometría alterada (eutróficos 27,5%, sobrepeso y obesidad 45,3%, p = 0,01). Tendencia lineal en asma no controlada (eutróficos 37,5%, sobrepeso 67,2%, obesos 63,9%p = 0.0008). Tendencia lineal en espirometría alterada (27,5%, 46,3%, 44,4%, p = 0,03), Conclusiones: Los asmáticos con sobrepeso y obesidad tienen una proporción significativamente mayor de asma no controlada y de espirometría alterada, que los asmáticos con estado nutricional normal. Existe una tendencia al aumento en las proporciones de asma no controlada y espirometría alterada al pasar de una categoría a otra de la clasificación nutricional. Introduction: Evidence suggests that overweight and obesity alter the control and lung function in asthmatic children. Aim: Measure the impact of overweight and obesity in the control and lung function of a population of persistent asthma in children. Material and Method: Nutritional evaluation, asthma control and spirometry were performed in patients with persistent asthma, 5 to 15 years of age controlled in a pediatric respiratory unit. We determined the presence of asthma symptoms, specific parameters for the management and predisposing factors according to the nutritional status. Differences between groups were evaluated using chisquare Mantel-Haenszel and trend; a p < 0.05 was considered significant. Results: 219 patientes were studied, males 60.3%, average age of8.5 years-old. The frequency of overweight and obesity reached 63.5%. Normal weight 36.5%, overweight 30.6% and obese 32.9%. Uncontrolled asthma (normal weight 37.5%, with overweight and obese 65.5%, p = 0.0001), abnormal spirometry (normal weight 27.5%, with overweight and obese 45.3%,p = 0.01). Uncontrolled asthma linear trend (normal weight 37.5%, overweight 67.2%, obese 63.9%, p = 0.0008). Abnormal spirometry linear trend (27.5%, 46.3%, 44.4%, p = 0.03). Conclusions: The asthmatics with overweight and obesity have a bigger proportion of uncontrolled asthma and abnormal spirometry than the asthmatics with normal weight. It exists a trend of uncontrolled asthma and abnormal spirometry when passing from one category to another of the nutritional classification.
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- 2012
8. Impacto del sobrepeso y la obesidad en el asma infantil
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Alberto Vidal G, Eliana Ceruti D, María Teresita Henríquez Y, Ana María Escobar C, and María Eugenia Medina R
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función pulmonar ,sobrepeso ,Control de asma ,General Medicine ,obesidad - Abstract
Introduccion: La evidencia sugiere que el sobrepeso y la obesidad alterarian el control y la funcion pulmonar de los ninos asmaticos. Objetivo: Medir el impacto del sobrepeso y obesidad en el control y funcion pulmonar de una poblacion de ninos asmaticos persistentes. Material y Metodo: Se realizo evaluacion nutricional, medicion de control de asma y espirometria a ninos asmaticos persistentes entre 5 y 15 anos, controlados en una Unidad de Enfermedades Respiratorias. Se determino la presencia de sintomas de asma, los parametros que permiten precisar su adecuado manejo y algunos factores predisponentes segun estado nutricional. Las diferencias entre grupos se evaluaron a traves del chi cuadrado de Mantel-Haenszel y el de tendencia, considerandose significativos valores de p < 0,05. Resultados: Se estudiaron a 219 ninos, sexo masculino 60,3%, promedio de edad de 8,5 anos. La frecuencia de sobrepeso y obesidad alcanzo el 63,5%. Asmaticos eutroficos 36,5%, con sobrepeso 30,6% y obesos 32,9%. Asma no controlada (eutroficos 37,5%, con sobrepeso y obesidad 65,5%, p = 0,0001), espirometria alterada (eutroficos 27,5%, sobrepeso y obesidad 45,3%, p = 0,01). Tendencia lineal en asma no controlada (eutroficos 37,5%, sobrepeso 67,2%, obesos 63,9%p = 0.0008). Tendencia lineal en espirometria alterada (27,5%, 46,3%, 44,4%, p = 0,03), Conclusiones: Los asmaticos con sobrepeso y obesidad tienen una proporcion significativamente mayor de asma no controlada y de espirometria alterada, que los asmaticos con estado nutricional normal. Existe una tendencia al aumento en las proporciones de asma no controlada y espirometria alterada al pasar de una categoria a otra de la clasificacion nutricional.
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- 2012
9. Educación en niños asmáticos controlados en hospital Roberto del Río: Impacto en conocimientos, adherencia y control de la enfermedad
- Author
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Henríquez, María Teresita, primary and Ceruti D, Eliana, additional
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- 2013
- Full Text
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10. Impacto del sobrepeso y la obesidad en el asma infantil
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Vidal G, Alberto, primary, Escobar C, Ana María, additional, Ceruti D, Eliana, additional, Henríquez Y, María Teresita, additional, and Medina R, María Eugenia, additional
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- 2012
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11. Etiología de las infecciones respiratorias bajas agudas en lactantes hospitalizados
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Ceruti D, Eliana, Díaz C, Armando, Vicente S, Manuela, Escobar C, Ana Maria, Martínez R, Fernando, Pinto M, Ricardo, León C, Agustín, Farias T, Pedro, and Torres I, Graciela
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etiología ,etiology ,respiratory tract infections ,lower respiratory infections ,infecciones respiratorias bajas - Published
- 1991
12. Etiología de las infecciones respiratorias bajas agudas en lactantes hospitalizados
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Agustín León C, Ricardo Pinto M, Pedro Farias T, Ana Maria Escobar C, Armando Díaz C, Graciela Torres I, Manuela Vicente S, Eliana Ceruti D, and Fernando Martínez R
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medicine.medical_specialty ,Respiratory tract infections ,etiología ,Pleural effusion ,business.industry ,medicine.disease_cause ,medicine.disease ,Gastroenterology ,infecciones respiratorias bajas ,Haemophilus influenzae ,Serology ,medicine.anatomical_structure ,White blood cell ,Internal medicine ,Pediatrics, Perinatology and Child Health ,Streptococcus pneumoniae ,medicine ,Etiology ,Chlamydia trachomatis ,business - Abstract
As a contribution to knowledge about the etiology of lower respiratory tract infections (LRI) in infants, 235 patients aged one year or less admitted to a children's hospital at northern metropolitan area of Santiago, Chile along years 1987 throughout 1989 with radiologically confirmed diagnosis were studied. Infants were eligible only if their symptoms lasted for not more than five days and their hospital stay was less than two days. Controls consisted on 74 healthy infants. A search for presumptive etiology was done by means of usual bacteriological procedures (pharyngeal swabs and blood cultures), plus latex test for type b Haemophilus influenzae (Hib) and Streptococcus pneumoniae (SP) in concentrated urine specimens; indirect immunofluorescence (IF) for specific Chlamydia trachomatis (CT) IgM; serological tests, isolation and IF in pharyngeal aspirates for syncytial respiratory virus (SRV), influenza, parainfluenzae and adenoviruses were also used. Evidence of viral infection was detected from 135/235 (57.5%) of cases and 21/74 (28.3%) controls, SRV being the most common. From 18/119 and 2/119 studied patients Hib and SP antigens were respectively detected, but urinary antigens were also present in 6/24 controls, raising questions about this test's specificity. IF titers of 1:32 or higher for CT were found in 5/80 patients, all younger than 5 months. It was possible to perform the whole set of available methods in 80 patients, in 70% of which some evidence of a known etiologic agent was found. Serology alone gave etiological clues in only 30% of these cases and usual microbiological cultures of throat swabs and blood from none of them. No combinations of age, fever, respiratory rate, apnea, bronchial obstructive syndrome, white blood cell counts over 15,000 or of band forms over 500 per cu mm, erythrocyte sedimentation rates, reactive C protein and x-ray findings allowed differential diagnosis between presumptive bacterial or viral etiology, except in one case of an infant presenting with pleural effusion and positive antigenuria for Hib.
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- 1991
13. Chlamydia trachomatosis pneumonia
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León C, Agustín, Ceruti D, Eliana, Díaz C, Armando, Pinto M, Ricardo, and Farias T, Pedro
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Chlamydia trachomatosis ,pneumonia ,neumonía ,urologic and male genital diseases ,infecciones respiratorias bajas ,female genital diseases and pregnancy complications - Published
- 1990
14. Etiología de las infecciones respiratorias bajas agudas en lactantes hospitalizados.
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Ceruti D, Eliana, primary, Díaz C, Armando, additional, Vicente S, Manuela, additional, Escobar C, Ana Maria, additional, Martínez R, Fernando, additional, Pinto M, Ricardo, additional, León C, Agustín, additional, Farias T, Pedro, additional, and Torres I, Graciela, additional
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- 1991
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15. Etiología de las infecciones respiratorias agudas bajas en lactantes hospitalizados. 3a- parte: investigación de Chlamydia trachomatis
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León C, Agustín, primary, Ceruti D, Eliana, additional, Díaz C, Armando, additional, Pinto M, Ricardo, additional, and Farias T, Pedro, additional
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- 1990
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16. Etiología de las infecciones agudas del tracto respiratorio bajo (IRAB) en lactantes hospitalizados: estudios virológicos
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Eliana Ceruti D, Graciela Torres, Manuela Vicente S, Patricia Vernal S, Pedro Farias T, Armando Díaz C, Ana Maria Escobar C, and Fernando Martínez R
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virus parainfluenza tipo 3 ,Pediatrics, Perinatology and Child Health ,infección de tracto respiratorio ,neumonia viral ,adenovirus ,virus respiratorio sincicial - Published
- 1988
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17. Virological studies in infants with low respiratory tract infections and in healthy controls
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Escobar C, Ana Maria, Martínez R, Fernando, Ceruti D, Eliana, Díaz C, Armando, Vicente S, Manuela, Farias T, Pedro, Torres, Graciela, and Vernal S, Patricia
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viruses ,virus parainfluenza tipo 3 ,respiratory syncytial virus ,infección de tracto respiratorio ,pneumonia viral ,adeno viruses ,neumonia viral ,adenovirus ,respiratory tract infections ,para influenza type 3 virus ,virus respiratorio sincicial - Published
- 1988
18. Valor del recuento de Eosinófilos en secreción nasal en el diagnóstico diferencial de los cuadros bronquiales obstructivos del niño
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G Mallea, Eliana Ceruti D, Armando Díaz C, N Marinov, Carlos Casar C, Mireya Bravo L, Z Lamas, and M Silva
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Gynecology ,medicine.medical_specialty ,Allergy ,obstructive bronchitis ,business.industry ,Eosinofilos en secreción nasal ,Diagnostico diferencial ,Nasal allergy ,Obstructive bronchitis ,medicine.disease ,Sindrome Bronquial Obstructivo ,Eosinophiles count in nasal secretions ,Pediatrics, Perinatology and Child Health ,Non allergic ,Medicine ,business - Abstract
RESUMEN 1.— Se estudia el numero de eosinofilos en la se-creci6n nasal de tres grupos de pacientes: ni-nos asmdticos, ninos con sindrome bronquialobstructive no alergico y un grupo control deninos sanos.2.— Se describe la tecnica usada: metodo de Han-sel.3.— Los resultados permiten concluir que el re-cuento de eosinofilos en secrecion nasal esun metodo jdcil y que puede ser de utilidadpara el diagnostico diferencial de cuadrosbronquiales alergicos y no alergicos.SUMMARY 1.— The eosinophiles Count in the nasal secretions isstudied in the groups of children: asthmatics, nonallergic obstructive bronchitis and a healthy controlgroup.2.— The Hansel method, wich was used, is described.3.— The results lead us to conclude that the eosinophi-les count in naisal secretions is an easy to practicemethod and that it might be helpful in the differen-tial diagnosis allergic and non allergic conditionsof the bronchi. REFERENCIAS 1.— Cerutl E. Asma bronquial. En Meneghello J. Pe-diatria. Pag. 63. Intermedica, Buenos Aires, 1972.2.— Dees S. Asthma. En Kendig E, Disorders of theRespiratory Tract in Children. W. B. Sauders Co.Pag. 449.3.~Tujt L., Mueller II. Allergy in Children. W. B.Saunders, Philadelphia, 1970.4.— Rhyne M. Pruebas cutaneas: conceptos y realida-des. Clinicas Pediatricas de N. A., Febrero, 1969,pag. 227.5.— Mansmann H. Tratamiento del nino con asmabronquial. Clinicas pedia~tricas de N. A. Mayo,1968, pag. 357.6.— Eyermann C. Nasal manifestations of allergy. Ann.Otolaryng Rhin and Laryng 32: 808, 1927. Ci-tado por Murray y Anderson, The J. of Allergy,43: 1, 1969.7.— Murray A. and Anderson D. The epidemiologicalrelationship of clinical nasal allergy to eosinophilsand to goblet cells in the nasal smears. The J. ofAllergy, 43
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- 1973
19. Fibrosis quística del páncreas: Estudio Clínico, de Laboratorio y Exploración Funcional Respiratoria. Seguimiento a largo plazo
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Vivaruo G, Guillermo, primary, Cucllar C, Aurelio, additional, Antelo A, Osvaldo, additional, and Ceruti D, Eliana, additional
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- 1979
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20. Etiología de las infecciones agudas del tracto respiratorio bajo (IRAB) en lactantes hospitalizados: estudios virológicos
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Escobar C, Ana Maria, primary, Martínez R, Fernando, additional, Ceruti D, Eliana, additional, Díaz C, Armando, additional, Vicente S, Manuela, additional, Farias T, Pedro, additional, Torres, Graciela, additional, and Vernal S, Patricia, additional
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- 1988
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21. Valor del recuento de Eosinófilos en secreción nasal en el diagnóstico diferencial de los cuadros bronquiales obstructivos del niño
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DIAZ C, ARMANDO, primary, BRAVO L, MIREYA, additional, CERUTI D, ELIANA, additional, CASAR C, CARLOS, additional, SILVA, M, additional, LAMAS, Z, additional, MARINOV, N, additional, and MALLEA, G, additional
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- 1973
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22. Prescriptive Appropriateness in Primary Cardiovascular Prevention: Data from Niguarda Hospital
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A. Maloberti, D. Ceruti, E. Gualini, V. Colombo, V. Giani, M. Milani, J. Sun, M. Alloni, C. Giannattasio, Maloberti, A, Ceruti, D, Gualini, E, Colombo, V, Giani, V, Milani, M, Sun, J, Alloni, M, and Giannattasio, C
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Physiology ,Internal Medicine ,Cardiology and Cardiovascular Medicine ,arterial hypertension, treatment, appropriate - Published
- 2022
23. Prescriptive Appropriateness in an Outpatient Primary and Secondary Cardiovascular Prevention Service.
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Ceruti D, Tognola C, Algeri M, Shkodra A, Politi F, Bellantonio V, Gualini E, Le Van M, Campana M, Pedroli S, Tedeschi Polmonari P, Brucato F, Giannattasio C, and Maloberti A
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- Humans, Male, Female, Middle Aged, Retrospective Studies, Aged, Italy epidemiology, Practice Patterns, Physicians', Blood Pressure Monitoring, Ambulatory, Guideline Adherence, Electrocardiography, Practice Guidelines as Topic, Inappropriate Prescribing prevention & control, Exercise Test, Predictive Value of Tests, Antihypertensive Agents therapeutic use, Heart Disease Risk Factors, Outpatients, Secondary Prevention, Ambulatory Care, Hypertension epidemiology, Hypertension diagnosis, Hypertension physiopathology, Primary Prevention, Cardiovascular Diseases prevention & control, Cardiovascular Diseases epidemiology, Cardiovascular Diseases diagnosis, Echocardiography
- Abstract
Introduction: In the absence of appropriateness specific guidelines, one important cause of health resources waste could be overuse of diagnostic procedures. Since arterial hypertension is a very frequent disease there could be such a risk in its management., Aim: To evaluate the prescriptive appropriateness of non-invasive diagnostic tests (echocardiography, carotid ultrasound, ECG exercise test, 24 h Ambulatory Blood Pressure Monitoring-ABPM) in a primary and secondary prevention outpatient's service., Methods: 559 outpatients visits were retrospectively analysed and appropriateness of every prescription was evaluated. An integration of different Italian and European guidelines was used to define appropriateness., Results: 449 prescriptions were made (198 echocardiography, 148 carotid ultrasound, 85 24 h ABPM and 18 ECG exercise testing). General appropriate prescriptions prevalence was 40.3%, 24 h ABPM being the most appropriate one (49.4%) followed by echocardiography (43.9%), ECG exercise test, (38.9%) and carotid ultrasound (30.4%). Appropriateness was significantly higher for secondary prevention patients (61.6 vs. 35.3%, p < 0.001) particularly for heart and carotid ultrasound. Significant univariate correlations were identified between age, cardiovascular risk category, degree of prevention (primary vs. secondary), duration of hypertension and the presence of valvular heart disease and prescription appropriateness. However, at multivariate analysis these findings were not confirmed., Conclusions: Our study shows a relevant percentage of inappropriate prescriptions of non-invasive cardiologic exams particularly in the primary prevention setting., Competing Interests: Declarations. Conflict of interest: The authors declare they have no conflict of interest., (© 2024. The Author(s).)
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- 2025
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24. Vitamin D levels and lipid profile in children and adolescents: a tight correlation.
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Ceruti D, Colombo C, Loiodice M, DE Leo S, Calcaterra V, and Fabiano V
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- Humans, Child, Adolescent, Dietary Supplements, Triglycerides blood, Cholesterol, HDL blood, Cholesterol, LDL blood, Vitamin D blood, Vitamin D Deficiency complications, Vitamin D Deficiency blood, Lipids blood
- Abstract
Introduction: Vitamin D is an essential hormone for humans, playing an important role in musculoskeletal and calcium homeostasis. Its deficiency/insufficiency seems to contribute to the development of cardiometabolic diseases in adults: this correlation appears less clear for children and adolescents. The aim of this paper was to review literature data on the relationship between vitamin D and lipid profile alterations in pediatric population., Evidence Acquisition: We carried out a comprehensive research in electronic databases, including MEDLINE and PubMed up to December 2022, for cross-sectional or prospective studies that investigated the correlation between serum vitamin D levels and lipid profile in children and adolescents. At the end of the process, 37 articles were included in this review., Evidence Synthesis: According to our findings, vitamin D deficiency/insufficiency is strongly associated with lower high-density lipoprotein (HDL) cholesterol levels and higher levels of triglycerides and total cholesterol. Data about low-density lipoproteins (LDL) cholesterol are inconsistent. The potential role of vitamin D supplements for the prevention of cardiometabolic disease currently remains a speculation., Conclusions: An increasing number of studies shows how hypovitaminosis D in the pediatric age may play a role in the pathogenesis of metabolic disorders and lipid profile alterations. Data regarding the potential role of vitamin D supplements for the prevention of cardiometabolic disease are currently controversial. Further studies are needed to evaluate the causality of this association and to assess the underlying pathogenetic mechanisms.
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- 2024
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25. The impact of vitamin D status on lipid profiles and atherogenic dyslipidemia markers in children and adolescents with obesity.
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Calcaterra V, Fabiano V, De Silvestri A, Colombo C, Tranfaglia V, Loiodice M, Ceruti D, and Zuccotti G
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- Humans, Child, Male, Female, Adolescent, Case-Control Studies, Age Factors, Risk Assessment, Cross-Sectional Studies, Prevalence, Risk Factors, Vitamin D Deficiency blood, Vitamin D Deficiency epidemiology, Vitamin D Deficiency diagnosis, Vitamin D blood, Vitamin D analogs & derivatives, Pediatric Obesity blood, Pediatric Obesity diagnosis, Pediatric Obesity epidemiology, Biomarkers blood, Dyslipidemias blood, Dyslipidemias epidemiology, Dyslipidemias diagnosis, Lipids blood, Atherosclerosis blood, Atherosclerosis epidemiology, Atherosclerosis diagnosis
- Abstract
Background and Aim: Adequate serum vitamin D levels correlate with a more favorable lipid profile compared to deficient levels. Despite the well-established prevalence of vitamin D deficiency in children with obesity, studies investigating its influence on lipid profiles in this population are scarce. We explored the impact of vitamin D status on lipid profiles and markers of atherogenic dyslipidemia in a cohort of children and adolescents with obesity., Methods and Results: A total of 271 Caucasian children and adolescents with overweight/obesity and a control group of 54 pediatric patients with normal weight. All participants underwent outpatient visits for the assessment of clinical parameters and venous blood collection for biochemical analysis such as triglycerides (TG)/HDL-C ratio, LDL-C/HDL-C ratio, atherogenic index of plasma AIP), vitamin D level. Individuals with obesity displayed severe vitamin D deficiency (25-OH-D ≤10 ng/ml) at a higher frequency compared to those with normal weight (p = 0.03). In patients with overweight/obesity and low 25-OH-D levels show higher values of glycemia (p = 0.001), insulin resistance (HOMA-IR and TRYG p < 0.001), TG (p < 0.001), TG/HDL-C (p = 0.001), AIP (p < 0.001), SBP (p = 0.01), and DBP (p = 0.04). In normal-weight individuals with low 25-OH- D levels an increased values of glycemia (p = 0.01), insulin resistance (HOMA-IR p = 0.01 and TRYG p = 0.002), TG (p = 0.01), TG/HDL-C (p = 0.02), AIP (p = 0.01). A direct correlation between 25-OH-D levels and metabolic parameters is observed., Conclusions: A correlation between vitamin D levels and the lipid/atherosclerotic profile was recorded. Vitamin D deficiency may represent a preventable and easily treatable cardiometabolic risk factor, emphasizing the importance of early intervention and preventive measures., Competing Interests: Declaration of competing interest The authors declare that they have no conflict of interests., (Copyright © 2024 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.)
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- 2024
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26. Impact of systemic treatments for advanced thyroid cancer on the adrenal cortex.
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Colombo C, Ceruti D, Succi M, De Leo S, Trevisan M, Moneta C, and Fugazzola L
- Subjects
- Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Adrenal Insufficiency drug therapy, Adrenocorticotropic Hormone blood, Antineoplastic Agents adverse effects, Antineoplastic Agents therapeutic use, Fatigue etiology, Hydrocortisone, Phenylurea Compounds adverse effects, Phenylurea Compounds therapeutic use, Quinazolines therapeutic use, Quinolines therapeutic use, Quinolines adverse effects, Adrenal Cortex drug effects, Adrenal Cortex metabolism, Piperidines adverse effects, Piperidines therapeutic use, Thyroid Neoplasms drug therapy, Thyroid Neoplasms pathology
- Abstract
Background: Fatigue is a frequent adverse event during systemic treatments for advanced thyroid cancer, often leading to reduction, interruption, or discontinuation. We were the first group to demonstrate a correlation between fatigue and primary adrenal insufficiency (PAI)., Aim: The objective was to assess the entire adrenal function in patients on systemic treatments., Methods: ACTH, cortisol and all the hormones produced by the adrenal gland were evaluated monthly in 36 patients (25 on lenvatinib, six on vandetanib, and five on selpercatinib). ACTH stimulation tests were performed in 26 cases., Results: After a median treatment period of 7 months, we observed an increase in ACTH values in 80-100% of patients and an impaired cortisol response to the ACTH test in 19% of cases. Additionally, dehydroepiandrosterone sulphate, ∆-4-androstenedione and 17-OH progesterone levels were below the median of normal values in the majority of patients regardless of the drug used. Testosterone in females and oestradiol in males were below the median of normal values in the majority of patients on lenvatinib and vandetanib. Finally, aldosterone was below the median of the normal values in most cases, whilst renin levels were normal. Metanephrines and normetanephrines were always within the normal range. Replacement therapy with cortisone acetate improved fatigue in 14/17 (82%) patients with PAI., Conclusion: Our data confirm that systemic treatments for advanced thyroid cancer can lead to impaired cortisol secretion. A reduction in the other hormones secreted by the adrenal cortex has been first reported and should be considered in the more appropriate management of these fragile patients.
- Published
- 2024
- Full Text
- View/download PDF
27. Management of hypertension during lenvatinib for advanced thyroid cancer: a suggested diagnostic and therapeutic algorithm.
- Author
-
Colombo C, Ceruti D, De Leo S, Bilo G, Trevisan M, Giancola N, Moneta C, Parati G, Persani L, and Fugazzola L
- Subjects
- Incidence, Proteinuria chemically induced, Humans, Follow-Up Studies, Retrospective Studies, Male, Female, Adult, Middle Aged, Aged, Aged, 80 and over, Hypertension chemically induced, Hypertension epidemiology, Antineoplastic Agents adverse effects, Antineoplastic Agents therapeutic use, Thyroid Neoplasms drug therapy, Phenylurea Compounds adverse effects, Phenylurea Compounds therapeutic use, Quinolines adverse effects, Quinolines therapeutic use
- Abstract
Background: Hypertension (HTN) is the most frequent adverse event during treatment with lenvatinib (LEN), but data on its best management are limited., Aim: The objective of this study was to assess incidence, features and best management of LEN-related HTN in a consecutive single tertiary-care centre cohort., Methods: Twenty-nine patients were followed up for a mean time of 29.8 months (6-77 months)., Results: After a mean follow-up of 6.8 months, HTN was recorded in 76% of cases, as a de novo occurrence in half of them. HTN significantly correlated with LEN dose and was of grade 1, grade 2 and grade 3 in 5%, 50% and 45% of patients, respectively. The majority (77%) of patients with HTN developed proteinuria. There was no correlation between HTN and proteinuria or clinical features or best morphological response or any other adverse event (AE), with the exception of diarrhoea. Patients with or without pre-existing HTN or any other cardiovascular disease had a similar incidence of HTN during LEN, thus excluding the impact of this potential predisposing factor. After evaluation by a dedicated cardiologist, medical treatment was introduced in 21/22 patients (polytherapy in 20 of them). The most frequently used drugs were calcium channel blockers (CCBs) due to their effect on vasodilation. In case of poor control, CCBs were associated with one or more anti-hypertensive drug., Conclusion: HTN is a frequent and early AE in patients on LEN treatment. We suggest a diagnostic and therapeutic algorithm to be applied in clinical practice to allow efficient HTN control and improve patient compliance, reducing LEN discontinuation.
- Published
- 2023
- Full Text
- View/download PDF
28. Persistent Thyroid Carcinoma and Pregnancy: Outcomes in an Italian Series and Review of the Literature.
- Author
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Colombo C, De Leo S, Giancola N, Trevisan M, Ceruti D, Frattini F, Persani L, and Fugazzola L
- Abstract
Scanty data are available on the progression risk in patients with persistent thyroid cancer (TC) before pregnancy. We aimed to evaluate this topic in our series and to review available literature data. This was a retrospective study performed in a tertiary care Italian TC center. We included 8 patients with persistent papillary TC who became pregnant after initial treatments (mean time interval of 62 months). Seven patients had the structural disease (lung and/or neck node metastases), while one patient had biochemical persistence. During a mean follow-up of 97 months, none of the patients showed disease progression either during pregnancy or during a follow-up of at least 12 months after delivery, and no additional treatments were needed. A sequential biochemical evaluation showed that thyroglobulin levels can significantly increase during pregnancy, returning to preconception levels after delivery. In conclusion, our data confirm that pregnancy is not associated with disease progression in patients with stable local and/or distant persistence before conception. Thus, pregnancy should not be contraindicated in metastatic women, although a precise clinical characterization, including the disease stage at diagnosis, the ATA risk class, and the dynamic risk stratification, should be conducted before conception.
- Published
- 2022
- Full Text
- View/download PDF
29. Gonadotropin-releasing hormone agonist (GnRH-A) in hirsutism.
- Author
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Falsetti L, Pasinetti E, and Ceruti D
- Subjects
- Adult, Androgens blood, Bone Density drug effects, Contraceptives, Oral, Combined administration & dosage, Cyproterone Acetate administration & dosage, Ethinyl Estradiol administration & dosage, Female, Follicle Stimulating Hormone blood, Hair growth & development, Hirsutism blood, Hirsutism etiology, Humans, Leuprolide adverse effects, Leuprolide pharmacology, Luteinizing Hormone blood, Polycystic Ovary Syndrome complications, Prolactin blood, Severity of Illness Index, Sex Hormone-Binding Globulin analysis, Hirsutism drug therapy, Leuprolide therapeutic use
- Abstract
Twenty-five women presenting moderate-severe PCOS-dependant hirsuitism were treated for 6 months with GnRH-A (Group A) or pill-combined and GnRH (Group B). Both therapeutic regimens significantly decreased androgen plasma levels. Hair diameter reduced in Group A by 22-34% and in Group B by 25-35%, while hirsuitism score respectively decreased by 22 and 24%. Clinical results, overlapping in the two groups, prove that GnRH-A are active in hirsuitism. Side effects, however, especially a decreased bone density (3.9%) in Group A make it necessary an association with oral contraceptive.
- Published
- 1994
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