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2. Sarilumab plus standard of care vs standard of care for the treatment of severe COVID-19: a phase 3, randomized, open-labeled, multi-center study (ESCAPE study)

Author

Agrati, Chiara, Andreoni, Massimo, Antinori, Andrea, Bai, Francesca, Beccacece, Alessia, Barreca, Filippo, Bertuccio, Maria Paola, Bini, Teresa, Boumis, Evangelo, Camici, Marta, Cauda, Roberto, Cerva, Carlotta, Cicalini, Stefania, Cingolani, Antonella, D'Arminio Monforte, Antonella, D'Urso, Angela, De Masi, Margherita, De Zottis, Federico, Del Borgo, Cosmo, Di Gennaro, Francesco, Emiliozzi, Arianna, Fantoni, Massimo, Fondaco, Laura, Fusto, Marisa, Gagliardini, Roberta, Giovannenze, Francesca, Grilli, Elisabetta, Iannetta, Marco, Iodice, Daniele, Lichtner, Miriam, Lorenzini, Patrizia, Maffongelli, Gaetano, Masone, Erminia, Massa, Barbara, Mastrorosa, Ilaria, Mazzotta, Valentina, Mencarini, Paola, Milozzi, Eugenia, Mondi, Annalisa, Mosti, Silvia, Murri, Rita, Negri, Marcantonio, Nicastri, Emanuele, Oliva, Gian Piero, Onnelli, Giovanna, Ottou, Sandrine, Pace, Pier Giorgio, Palmieri, Fabrizio, Paulicelli, Jessica, Pinnetti, Carmela, Plazzi, Maria Maddalena, Sarmati, Loredana, Segala, Francesco Vladimiro, Sorace, Chiara, Taddei, Eleonora, Vergori, Alessandra, Vitale, Pietro, Lamonica, Silvia, Girardi, Enrico, and Vaia, Francesco

Published
2023
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4. Clinical features and comorbidity pattern of HCV infected migrants compared to native patients in care in Italy: A real-life evaluation of the PITER cohort

Author

Mazzaro, Cesare, Bertola, Manuela, Schioppa, Ornella, Benedetti, Antonio, Schiadà, Laura, Cucco, Monica, Giacometti, Andrea, Brescini, Laura, Castelletti, Sefora, Fiorentini, Alessandro, Angarano, Gioacchino, Milella, Michele, Di Leo, Alfredo, Rendina, Maria, D'abramo, Fulvio Salvatore, Lillo, Chiara, Iannone, Andrea, Piazzolla, Mariano, Verucchi, Gabriella, Badia, Lorenzo, Piscaglia, Fabio, Benevento, Francesca, Serio, Ilaria, Castelli, Francesco, Zaltron, Serena, Spinetti, Angiola, Odolini, Silvia, Bruno, Raffaele, Mondelli, Mario, Chessa, Luchino, Loi, Martina, Torti, Carlo, Costa, Chiara, Mazzitelli, Maria, Pisani, Vincenzo, Scaglione, Vincenzo, Trecarichi, Enrico Maria, Zignego, Anna Linda, Monti, Monica, Madia, Francesco, Blanc, Pier Luigi, Attala, Letizia, Pierotti, Piera, Salomoni, Elena, Mariabelli, Elisa, Santantonio, Teresa Antonia, Bruno, Serena Rita, Cela, Ester Marina, Bassetti, Matteo, Mazzarello, Giovanni, Alessandrini, Anna Ida, Di Biagio, Antonio, Nicolini, Laura Ambra, Raimondo, Giovanni, Filomia, Roberto, Aghemo, Alessio, Meli, Rossella, Lazzarin, Adriano, Morsica, Giulia, Salpietro, Stefania, Galli, Massimo, Fracanzani, Anna Ludovica, Fatta, Erika, Lombardi, Rosa, Lampertico, Pietro, Borghi, Marta, D'ambrosio, Roberta, Degasperi, Elisabetta, Puoti, Massimo, Baiguera, Chiara, D'amico, Federico, Vinci, Maria, Rumi, Maria Grazia, Zuin, Massimo, Giorgini, Alessia, Zermiani, Paola, Andreone, Pietro, Caraceni, Paolo, Margotti, Marzia, Guarneri, Valeria, Villa, Erica, Bernabucci, Veronica, Bristot, Laura, Paradiso, Maria Luisa, Migliorino, Guglielmo, Beretta, Ilaria, Gambaro, Alessandra, Lapadula, Giuseppe, Spolti, Anna, Soria, Alessandro, Invernizzi, Pietro, Ciaccio, Antonio, LucÀ, Martina, Malinverno, Federica, Ratti, Laura, Coppola, Carmine, Amoruso, Daniela Caterina, Pisano, Federica, Scarano, Ferdinando, Staiano, Laura, Morisco, Filomena, Cossiga, Valentina, Gentile, Ivan, Buonomo, Antonio Riccardo, Foggia, Maria, Zappulo, Emanuela, Federico, Alessandro, Dallio, Marcello, Coppola, Nicola, Sagnelli, Caterina, Martini, Salvatore, Monari, Caterina, Nardone, Gerardo, Sgamato, Costantino, Chemello, Liliana, Cavalletto, Luisa, Sterrantino, Daniela, Russo, Francesco Paolo, Zanetto, Alberto, Zanaga, Paola, Barbaro, Francesco, Brancaccio, Giuseppina, Craxì, Antonio, Petta, Salvatore, Calvaruso, Vincenza, Crapanzano, Luciano, Madonia, Salvatore, Cannizzaro, Marco, Bruno, Erica Maria, Licata, Anna, Amodeo, Simona, Capitano, Adele Rosaria, Ferrari, Carlo, Laccabue, Diletta, Negri, Elisa, Orlandini, Alessandra, Pesci, Marco, Gulminetti, Roberto, Pagnucco, Layla, Parruti, Giustino, Di Stefano, Paola, Brunetto, Maurizia Rossana, Coco, Barbara, Massari, Marco, Corsini, Romina, Garlassi, Elisa, Andreoni, Massimo, Teti, Elisabetta, Cerva, Carlotta, Baiocchi, Lorenzo, Tata, Xhimi, Grassi, Giuseppe, Gasbarrini, Antonio, Pompili, Maurizio, De Siena, Martina, Taliani, Gloria, Biliotti, Elisa, Spaziante, Martina, Persico, Marcello, Masarone, Mario, Aglitti, Andrea, Calvanese, Gemma, Anselmo, Marco, De Leo, Pasqualina, Marturano, Monica, Saracco, Giorgio Maria, Ciancio, Alessia, Ieluzzi, Donatella, Quaranta, Maria Giovanna, Ferrigno, Luigina, D'Angelo, Franca, Saracino, Annalisa, and Kondili, Loeta A.

Published
2021
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5. Risk and predictive factors of prolonged viral RNA shedding in upper respiratory specimens in a large cohort of COVID-19 patients admitted to an Italian reference hospital

Author

Abbonizio, Maria Alessandra, Abdeddaim, Amina, Agostini, Elisabetta, Agrati, Chiara, Albarello, Fabrizio, Amadei, Gioia, Amendola, Alessandra, Antinori, Andrea, Antonica, Maria Assunta, Antonini, Mario, Bartoli, Tommaso Ascoli, Baldini, Francesco, Barbaro, Raffaella, Bartolini, Barbara, Bellagamba, Rita, Benigni, Martina, Bevilacqua, Nazario, Biava, Gianluigi, Bibas, Michele, Bordi, Licia, Bordoni, Veronica, Boumis, Evangelo, Branca, Marta, Buonomo, Rosanna, Busso, Donatella, Camici, Marta, Campioni, Paolo, Canichella, Flaminia, Capobianchi, Maria Rosaria, Capone, Alessandro, Caporale, Cinzia, Caraffa, Emanuela, Caravella, Ilaria, Carletti, Fabrizio, Castilletti, Concetta, Cataldo, Adriana, Cerilli, Stefano, Cerva, Carlotta, Chiappini, Roberta, Chinello, Pierangelo, Cianfarani, Maria Assunta, Ciaralli, Carmine, Cimaglia, Claudia, Cinicola, Nicola, Ciotti, Veronica, Cicalini, Stefania, Colavita, Francesca, Corpolongo, Angela, Cristofaro, Massimo, Curiale, Salvatore, D’Abramo, Alessandra, Dantimi, Cristina, De Angelis, Alessia, De Angelis, Giada, De Palo, Maria Grazia, De Zottis, Federico, Di Bari, Virginia, Di Lorenzo, Rachele, Di Stefano, Federica, D’Offizi, Gianpiero, Donno, Davide, Evangelista, Francesca, Faraglia, Francesca, Farina, Anna, Ferraro, Federica, Fiorentini, Lorena, Frustaci, Andrea, Fusetti, Matteo, Galati, Vincenzo, Gagliardini, Roberta, Gallì, Paola, Garotto, Gabriele, Gaviano, Ilaria, Tekle, Saba Gebremeskel, Giancola, Maria Letizia, Giansante, Filippo, Giombini, Emanuela, Granata, Guido, Greci, Maria Cristina, Grilli, Elisabetta, Grisetti, Susanna, Gualano, Gina, Iacomi, Fabio, Iaconi, Marta, Iannicelli, Giuseppina, Inversi, Carlo, Ippolito, Giuseppe, Lalle, Eleonora, Lamanna, Maria Elena, Lanini, Simone, Lapa, Daniele, Lepore, Luciana, Libertone, Raffaella, Lionetti, Raffaella, Liuzzi, Giuseppina, Loiacono, Laura, Lucia, Andrea, Lufrani, Franco, Macchione, Manuela, Maffongelli, Gaetano, Marani, Alessandra, Marchioni, Luisa, Mariano, Andrea, Marini, Maria Cristina, Maritti, Micaela, Mastrobattista, Annelisa, Mastrorosa, Ilaria, Matusali, Giulia, Mazzotta, Valentina, Mencarini, Paola, Meschi, Silvia, Messina, Francesco, Micarelli, Sibiana, Mogavero, Giulia, Mondi, Annalisa, Montalbano, Marzia, Montaldo, Chiara, Mosti, Silvia, Murachelli, Silvia, Musso, Maria, Nardi, Michela, Navarra, Assunta, Nicastri, Emanuele, Nocioni, Martina, Noto, Pasquale, Noto, Roberto, Oliva, Alessandra, Onnis, Ilaria, Ottou, Sandrine, Palazzolo, Claudia, Pallini, Emanuele, Palmieri, Fabrizio, Palombi, Giulio, Pareo, Carlo, Passeri, Virgilio, Pelliccioni, Federico, Penna, Giovanna, Petrecchia, Antonella, Petrone, Ada, Petrosillo, Nicola, Pianura, Elisa, Pinnetti, Carmela, Pisciotta, Maria, Piselli, Pierluca, Pittalis, Silvia, Pontarelli, Agostina, Proietti, Costanza, Puro, Vincenzo, Ramazzini, Paolo Migliorisi, Rianda, Alessia, Rinonapoli, Gabriele, Rosati, Silvia, Rubino, Dorotea, Rueca, Martina, Ruggeri, Alberto, Sacchi, Alessandra, Sampaolesi, Alessandro, Sanasi, Francesco, Santagata, Carmen, Scarabello, Alessandra, Scarcia, Silvana, Schininà, Vincenzo, Scognamiglio, Paola, Scorzolini, Laura, Stazi, Giulia, Strano, Giacomo, Taglietti, Fabrizio, Taibi, Chiara, Taloni, Giorgia, Nardi, Tetaj, Tonnarini, Roberto, Topino, Simone, Tozzi, Martina, Vaia, Francesco, Vairo, Francesco, Valli, Maria Beatrice, Vergori, Alessandra, Vincenzi, Laura, Visco-Comandini, Ubaldo, Vita, Serena, Vittozzi, Pietro, Zaccarelli, Mauro, Zanetti, Antonella, Zito, Sara, Lorenzini, Patrizia, Di Gennaro, Francesco, and Girardi, Enrico

Published
2021
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6. Utility of Liver Biopsy in the Diagnosis and Management of Possible Drug-Induced Liver Injury in Patients Receiving Antituberculosis Therapy: A Retrospective Study

Author

Gualano, Gina, primary, Zace, Drieda, additional, Mosti, Silvia, additional, Mencarini, Paola, additional, Musso, Maria, additional, Libertone, Raffaella, additional, Cerva, Carlotta, additional, Goletti, Delia, additional, Rianda, Alessia, additional, Del Nonno, Franca, additional, Falasca, Laura, additional, and Palmieri, Fabrizio, additional

Published
2023
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8. Integrase strand transfer inhibitor-based regimen is related with a limited HIV-1 V3 loop evolution in clinical practice

Author

Alteri, Claudia, Scutari, Rossana, Bertoli, Ada, Armenia, Daniele, Gori, Caterina, Fabbri, Gabriele, Mastroianni, Claudio Maria, Cerva, Carlotta, Cristaudo, Antonio, Vicenti, Ilaria, Bruzzone, Bianca, Zazzi, Maurizio, Andreoni, Massimo, Antinori, Andrea, Svicher, Valentina, Ceccherini-Silberstein, Francesca, Perno, Carlo Federico, and Santoro, Maria Mercedes

Published
2019
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9. Sarilumab plus standard of care vs standard of care for the treatment of severe COVID-19: a phase 3, randomized, open-labeled, multi-center study (ESCAPE study)

Author

Mastrorosa, Ilaria, primary, Gagliardini, Roberta, additional, Segala, Francesco Vladimiro, additional, Mondi, Annalisa, additional, Lorenzini, Patrizia, additional, Cerva, Carlotta, additional, Taddei, Eleonora, additional, Bai, Francesca, additional, Vergori, Alessandra, additional, Negri, Marcantonio, additional, Pinnetti, Carmela, additional, Cicalini, Stefania, additional, Murri, Rita, additional, Mazzotta, Valentina, additional, Camici, Marta, additional, Mosti, Silvia, additional, Bini, Teresa, additional, Maffongelli, Gaetano, additional, Beccacece, Alessia, additional, Milozzi, Eugenia, additional, Iannetta, Marco, additional, Lamonica, Silvia, additional, Fusto, Marisa, additional, Plazzi, Maria Maddalena, additional, Ottou, Sandrine, additional, Lichtner, Miriam, additional, Fantoni, Massimo, additional, Andreoni, Massimo, additional, Sarmati, Loredana, additional, Cauda, Roberto, additional, Girardi, Enrico, additional, Nicastri, Emanuele, additional, D'Arminio Monforte, Antonella, additional, Palmieri, Fabrizio, additional, Cingolani, Antonella, additional, Vaia, Francesco, additional, Antinori, Andrea, additional, Agrati, Chiara, additional, Barreca, Filippo, additional, Bertuccio, Maria Paola, additional, Boumis, Evangelo, additional, D'Urso, Angela, additional, De Masi, Margherita, additional, De Zottis, Federico, additional, Del Borgo, Cosmo, additional, Di Gennaro, Francesco, additional, Emiliozzi, Arianna, additional, Fondaco, Laura, additional, Giovannenze, Francesca, additional, Grilli, Elisabetta, additional, Iodice, Daniele, additional, Masone, Erminia, additional, Massa, Barbara, additional, Mastrorosa, Ilaria, additional, Mencarini, Paola, additional, Oliva, Gian Piero, additional, Onnelli, Giovanna, additional, Pace, Pier Giorgio, additional, Paulicelli, Jessica, additional, Sorace, Chiara, additional, and Vitale, Pietro, additional

Published
2023
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10. Characterization of the immune impairment of tuberculosis and COVID-19 coinfected patients

Author

Najafi-Fard, Saeid, primary, Aiello, Alessandra, additional, Navarra, Assunta, additional, Cuzzi, Gilda, additional, Vanini, Valentina, additional, Migliori, Giovanni Battista, additional, Gualano, Gina, additional, Cerva, Carlotta, additional, Grifoni, Alba, additional, Sette, Alessandro, additional, Vaia, Francesco, additional, Palmieri, Fabrizio, additional, and Goletti, Delia, additional

Published
2023
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11. Microbiologic characteristics and predictors of mortality in bloodstream infections in intensive care unit patients: A 1-year, large, prospective surveillance study in 5 Italian hospitals

Author

Delle Rose, Diego, Sordillo, Pasquale, Gini, Sabina, Cerva, Carlotta, Boros, Stefano, Rezza, Giovanni, Meledandri, Marcello, Gallo, Maria Teresa, Prignano, Grazia, Caccese, Roberta, D'Ambrosio, Mario, Citterio, Giorgia, Rocco, Monica, Leonardis, Francesca, Natoli, Silvia, Fontana, Carla, Favaro, Marco, Celeste, Maria Grazia, Franci, Tiziana, Testore, Gian Piero, Andreoni, Massimo, and Sarmati, Loredana

Published
2015
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12. Hepatitis B virus reactivation sustained by a hepatitis B virus surface antigen immune-escape mutant isolate in a patient who was hepatitis B core antibody positive during treatment with sofosbuvir and velpatasvir for hepatitis C virus infection: a case report

Author

Foroghi Biland, Luca, Ferrari, Ludovica, Malagnino, Vincenzo, Teti, Elisabetta, Cerva, Carlotta, Gentile, Adele, Aragri, Marianna, Salpini, Romina, Svicher, Valentina, Andreoni, Massimo, and Sarmati, Loredana

Published
2019
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14. Highly Sensitive HBsAg, Anti-HBc and Anti HBsAg Titres in Early Diagnosis of HBV Reactivation in Anti-HBc-Positive Onco-Haematological Patients

Author

Cerva, Carlotta, primary, Salpini, Romina, additional, Alkhatib, Mohammad, additional, Malagnino, Vincenzo, additional, Piermatteo, Lorenzo, additional, Battisti, Arianna, additional, Bertoli, Ada, additional, Gersch, Jeff, additional, Holzmayer, Vera, additional, Kuhns, Mary, additional, Cloherty, Gavin, additional, Ferrari, Ludovica, additional, Laura, Campogiani, additional, Teti, Elisabetta, additional, Cantonetti, Maria, additional, Arcese, William, additional, Ceccherini-Silberstein, Francesca, additional, Perno, Carlo-Federico, additional, Andreoni, Massimo, additional, Svicher, Valentina, additional, and Sarmati, Loredana, additional

Published
2022
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15. Sarilumab Plus Standard of Care Versus Standard of Care for the Treatment of Severe COVID-19: A Phase 3, Randomized, Open-Labeled, Multi-Center Study (ESCAPE Study)

Author

Mastrorosa, Ilaria, primary, Gagliardini, Roberta, additional, Segala, Francesco, additional, Mondi, Annalisa, additional, Lorenzini, Patrizia, additional, Cerva, Carlotta, additional, Taddei, Eleonora, additional, Bai, Francesca, additional, Vergori, Alessandra, additional, Marcantonio, Negri, additional, Pinnetti, Carmela, additional, Cicalini, Stefania, additional, Murri, Rita, additional, Mazzotta, Valentina, additional, Camici, Marta, additional, Mosti, Silvia, additional, Bini, Teresa, additional, Maffongelli, Gaetano, additional, Beccacece, Alessia, additional, Milozzi, Eugenia, additional, Iannetta, Marco, additional, Lamonica, Silvia, additional, Fusto, Marisa, additional, Plazzi, Maria Maddalena, additional, Ottou, Sandrine, additional, Lichtner, Miriam, additional, Fantoni, Massimo, additional, Andreoni, Massimo, additional, Sarmati, Loredana, additional, Cauda, Roberto, additional, Girardi, Enrico, additional, Nicastri, Emanuele, additional, D'Arminio Monforte, Antonella, additional, Palmieri, Fabrizio, additional, Cingolani, Antonella, additional, Vaia, Francesco, additional, Antinori, Andrea, additional, and Group, ESCAPE Study, additional

Published
2022
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16. Highly sensitive HBsAg, anti-HBc and anti HBsAg titres in Early Diagnosis of HBV Reactivation in Anti-HBc-Positive onco-haematological Patients.

Author

Cerva, Carlotta, primary, Salpini, Romina, additional, Alkhatib, Mohammad, additional, Malagnino, Vincenzo, additional, Piermatteo, Lorenzo, additional, Battisti, Arianna, additional, Bertoli, Ada, additional, Gersch, Jeff, additional, Holzmayer, Vera, additional, Kuhns, Mary, additional, Cloherty, Gavin, additional, Ferrari, Ludovica, additional, Laura, Campogiani, additional, Teti, Elisabetta, additional, Cantonetti, Maria, additional, Arcese, William, additional, Ceccherini-Silberstein, Francesca, additional, Perno, Carlo-Federico, additional, Andreoni, Massimo, additional, Svicher, Valentina, additional, and Sarmati, Loredana, additional

Published
2021
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17. Microbiologic characteristics and predictors of mortality in bloodstream infections in intensive care unit patients: A 1-year, large, prospective surveillance study in 5 Italian hospitals

Author

Rose, Diego Delle, Sordillo, Pasquale, Gini, Sabina, Cerva, Carlotta, Boros, Stefano, Rezza, Giovanni, Meledandri, Marcello, Gallo, Maria Teresa, Prignano, Grazia, Caccese, Roberta, DʼAmbrosio, Mario, Citterio, Giorgia, Rocco, Monica, Leonardis, Francesca, Natoli, Silvia, Fontana, Carla, Favaro, Marco, Celeste, Maria Grazia, Franci, Tiziana, Testore, Gian Piero, Andreoni, Massimo, and Sarmati, Loredana

Published
2015
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18. HBeAg Levels Vary across the Different Stages of HBV Infection According to the Extent of Immunological Pressure and Are Associated with Therapeutic Outcome in the Setting of Immunosuppression-Driven HBV Reactivation

Author

Piermatteo, Lorenzo, primary, Alkhatib, Mohammad, additional, D’Anna, Stefano, additional, Malagnino, Vincenzo, additional, Bertoli, Ada, additional, Andreassi, Eleonora, additional, Basile, Elisa, additional, Iuvara, Alessandra, additional, De Cristofaro, Maria, additional, Cappiello, Giuseppina, additional, Cerva, Carlotta, additional, Minichini, Carmine, additional, Pisaturo, Mariantonietta, additional, Starace, Mario, additional, Coppola, Nicola, additional, Fontana, Carla, additional, Grelli, Sandro, additional, Ceccherini-Silberstein, Francesca, additional, Andreoni, Massimo, additional, Gill, Upkar S., additional, Kennedy, Patrick T. F., additional, Sarmati, Loredana, additional, Salpini, Romina, additional, and Svicher, Valentina, additional

Published
2021
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19. Common and Rare Hematological Manifestations and Adverse Drug Events during Treatment of Active TB: A State of Art

Author

Minardi, Maria Letizia, primary, Fato, Ilenia, additional, Di Gennaro, Francesco, additional, Mosti, Silvia, additional, Mastrobattista, Annelisa, additional, Cerva, Carlotta, additional, Libertone, Raffaella, additional, Saracino, Annalisa, additional, Goletti, Delia, additional, Girardi, Enrico, additional, Andreoni, Massimo, additional, Palmieri, Fabrizio, additional, and Gualano, Gina, additional

Published
2021
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20. Predicting respiratory failure in patients infected by SARS-CoV-2 by admission sex-specific biomarkers

Author

Pagano, MARIA TERESA, Daniela, Peruzzu, Busani, Luca, Marina, Pierdominici, Anna, Ruggieri, Andrea, Antinori, Gianpiero, D'Offizi, Nicola, Petrosillo, Fabrizio, Palmieri, Pierluca, Piselli, Cicalini, Stefania, Stefania, Notari, Nicastri, Emanuele, Chiara, Agrati, Ippolito, Giuseppe, Vaia, Francesco, Maria Cristina Gagliardi, Capobianchi, Maria Rosaria, Ortona, Elena, Manuela, Macchione, Rachele Di Lorenzo, Marta, Camici, Roberta, Gagliardini, Vita, Serena, Maffongelli, Gaetano, Eugenia, Milozzi, Francesca, Faraglia, Cerva, Carlotta, Silvia, Mosti, Davide Roberto Donno, Pierangelo, Chinello, Bordoni, Veronica, Alessandra, Sacchi, Tartaglia, Eleonora, Rita, Casetti, Grassi, Germana, Eleonora, Cimini, Maria Luisa Dupuis, Anticoli, Simona, Fecchi, Katia, Bellenghi, Maria, Puglisi, Rossella, Gianfranco, Mattia, Giada Pontecorvi and, Pagano, M. T., Peruzzu, D., Busani, L., Pierdominici, M., Ruggieri, A., Antinori, A., D'Offizi, G., Petrosillo, N., Palmieri, F., Piselli, P., Cicalini, S., Notari, S., Nicastri, E., Agrati, C., Ippolito, G., Vaia, F., Gagliardi, M. C., Capobianchi, M. R., Ortona, E., Macchione, M., Di Lorenzo, R., Camici, M., Gagliardini, R., Vita, S., Maffongelli, G., Milozzi, E., Faraglia, F., Cerva, C., Mosti, S., Donno, D. R., Chinello, P., Bordoni, V., Sacchi, A., Tartaglia, E., Casetti, R., Grassi, G., Cimini, E., Dupuis, M. L., Anticoli, S., Fecchi, K., Bellenghi, M., Puglisi, R., Mattia, G., and Pontecorvi, G.

Subjects
Adult, Male, ARDS, medicine.medical_specialty, Angiotensins, Physiology, Angiotensin1-7, Respiratory monitoring, Gender Studies, Angiotensin, Endocrinology, Internal medicine, Medicine, QP1-981, Humans, Testosterone, Respiratory system, angiotensin1-7, biomarkers, COVID-19, estrogen, gender, sex, testosterone, Respiratory Distress Syndrome, Sex Characteristics, Estradiol, business.industry, SARS-CoV-2, Research, Gender, Biomarker, Middle Aged, medicine.disease, Estrogen, Hospitalization, Respiratory failure, Absolute neutrophil count, Biomarker (medicine), Sex, Female, Angiotensin-Converting Enzyme 2, business, Respiratory Insufficiency, Biomarkers, Hormone, Human
Abstract

Background Several biomarkers have been identified to predict the outcome of COVID-19 severity, but few data are available regarding sex differences in their predictive role. Aim of this study was to identify sex-specific biomarkers of severity and progression of acute respiratory distress syndrome (ARDS) in COVID-19. Methods Plasma levels of sex hormones (testosterone and 17β-estradiol), sex-hormone dependent circulating molecules (ACE2 and Angiotensin1-7) and other known biomarkers for COVID-19 severity were measured in male and female COVID-19 patients at admission to hospital. The association of plasma biomarker levels with ARDS severity at admission and with the occurrence of respiratory deterioration during hospitalization was analysed in aggregated and sex disaggregated form. Results Our data show that some biomarkers could be predictive both for males and female patients and others only for one sex. Angiotensin1-7 plasma levels and neutrophil count predicted the outcome of ARDS only in females, whereas testosterone plasma levels and lymphocytes counts only in males. Conclusions Sex is a biological variable affecting the choice of the correct biomarker that might predict worsening of COVID-19 to severe respiratory failure. The definition of sex specific biomarkers can be useful to alert patients to be safely discharged versus those who need respiratory monitoring.

Published
2021

21. HBcAb Positivity Increases the Risk of Severe Hepatic Fibrosis Development in HIV/HCV-Positive Subjects from the ICONA Italian Cohort of HIV-Infected Patients

Author

Malagnino, Vincenzo, Cerva, Carlotta, Cingolani, Antonella, Ceccherini-Silberstein, Francesca, Vergori, Alessandra, Cuomo, Gianluca, Perno, Carlo Federico, Puoti, Massimo, d'Arminio Monforte, Antonella, Cozzi-Lepri, Alessandro, Andreoni, Massimo, Sarmati, Loredana, d’Arminio Monforte (President), Icona Fundation Study Group. Board of Directors: A., Antinori (Vice-President), A., Andreoni, M., Castagna, A., Castelli, F., Cauda, R., Di Perri, G., Galli, M., Iardino, R., Ippolito, G., Lazzarin, A., Marchetti, G. C., Rezza, G., von Schloesser, F., d’Arminio Monforte, P. Viale. Scientific Secretary: A., Antinori, A., Ceccherinisilberstein, F., Cozzi-Lepri, A., Girardi, E., Gori, A., Lo Caputo, S., Maggiolo, F., Mussini, C., Puoti, M., Antinori, C. F. Perno. Steering Committee: A., Bai, F., Bandera, A., Bonora, S., Borderi, M., Calcagno, A., Capobianchi, M. R., Ceccherini-Silberstein, F., Cicalini, S., Cingolani, A., Cinque, P., d’Arminio Monforte, A., Di Biagio, A., Gagliardini, R., Gianotti, N., Guaraldi, G., Lapadula, G., Lichtner, M., Lai, A., Madeddu, G., Marchetti, G., Merlini, E., Nozza, S., Perno, C. F., Piconi, S., Pinnetti, C., Quiros Roldan, E., Rossotti, R., Rusconi, S., Santoro, M. M., Saracino, A., Sarmati, L., Spagnuolo, V., Svicher, V., Taramasso, L., Cozzi-Lepri, Statistical and Monitoring Team: A., Fanti, I., Galli, L., Lorenzini, P., Rodanó, A., Macchia, M., Bove, A. Tavelli. Community Advisory Board: A., Camposeragna, A., Errico, M., Manfredini, M., Perziano, A., Carletti, V. Calvino. Biological Bank INMI: F., Carrara, S., Di Caro, A., Graziano, S., Petroni, F., Prota, G., Giacometti, S. Truffa. Participating Physicians and Centers: Italy: A., Costantini, A., Barocci (Ancona), V., Angarano, G., Monno, L., Milano (Bari), E., F. Maggiolo, C. Suardi (Bergamo), Viale, P., Donati, V., Verucchi (Bologna), G., Castelnuovo, F., Minardi, C., Quiros Roldan (Brescia), E., B. Menzaghi, C. Abeli (Busto Arsizio), L. Chessa, F. Pes (Cagliarti), B. Cacopardo, B. Celesia (Catania), J. Vecchiet, K. Falasca (Chieti), A. Pan, S. Lorenzotti (Cremona), L. Sighinolfi, D. Segala (Ferrara), P. Blanc, F. Vichi (Firenze), Cassola, G., Bassetti, M., Alessandrini, A., Bobbio, N., Mazzarello (Genova), G., M. Lichtner, L. Fondaco (Latina), P. Bonfanti, C. Molteni (Lecco), A. Chiodera, P. Milini (Macerata), G. Nunnari, G. Pellicanò (Messina), Rizzardini, G., Cannizzo, E. S., Moioli, M. C., Piolini, R., Bernacchia, D., Poli, A., Tincati (Milano), C., C. Mussini, C. Puzzolante (Modena), C. Migliorino, G. Lapadula (Monza), Sangiovanni, V., Borgia, G., Esposito, V., Di Flumeri, G., Gentile, I., Rizzo (Napoli), V., A. M. Cattelan, S. Marinello (Padova), A. Cascio, M. Trizzino (Palermo), D. Francisci, E. Schiaroli (Perugia), G. Parruti, F. Sozio (Pescara), C. Lazzaretti, R. Corsini (Reggio Emilia), Cristaudo, A., Vullo, V., Acinapura, R., Lamonica, S., Capozzi, M., Mondi, A., Rivano Capparuccia, M., Iaiani, G., Latini, A., Onnelli, G., Plazzi, M. M., De Girolamo, G., Vergori (Roma), A., M. Cecchetto, F. Viviani (Rovigo), G. Madeddu, A. De Vito (Sassari), B. Rossetti, F. Montagnani (Siena), A. Franco, R. Fontana Del Vecchio (Siracusa), Di Giuli (Terni), C., Caramello, P., Orofino, G. C., Sciandra (Torino), M., Londero (Udine), A., V. Manfrin, G. Battagin (Vicenza), G. Starnini, A. Ialungo (Viterbo)., Malagnino, V, Cerva, C, Cingolani, A, Ceccherini-Silberstein, F, Vergori, A, Cuomo, G, Perno, C, Puoti, M, D'Arminio Monforte, A, Cozzi-Lepri, A, Andreoni, M, Sarmati, L, Malagnino, V., Cerva, C., Cingolani, A., Ceccherini-Silberstein, F., Vergori, A., Cuomo, G., Perno, C. F., Puoti, M., D'Arminio Monforte, A., Cozzi-Lepri, A., Andreoni, M., Sarmati, L., ICONA Foundation Study, Group, Castagna, A., Malagnino V., Cerva C., Cingolani A., Ceccherini-Silberstein F., Vergori A., Cuomo G., Perno C.F., Puoti M., D'Arminio Monforte A., Cozzi-Lepri A., Andreoni M., and Sarmati L.A Castagna, F Castelli, R Cauda, G Di Perri, M Galli, R Iardino, G Ippolito, A Lazzarin, G C Marchetti, G Rezza, F von Schloesser, E Girardi, A Gori, S Lo Caputo, F Maggiolo, F Bai, A Bandera, S Bonora, M Borderi, A Calcagno, M R Capobianchi, S Cicalini, P Cinque, A Di Biagio, R Gagliardini, N Gianotti, G Guaraldi, G Lapadula, M Lichtner, A Lai, S Lo Caputo, G Madeddu, G Marchetti, E Merlini, C Mussini, S Nozza, S Piconi, C Pinnetti, E Quiros Roldan, R Rossotti, S Rusconi, M M Santoro, A Saracino, V Spagnuolo, V Svicher, L Taramasso, I Fanti, L Galli, P Lorenzini, A Rodanó, M Macchia, A Tavelli, A Bove, A Camposeragna, M Errico, M Manfredini, A Perziano, V Calvino, F Carletti, S Carrara, A Di Caro, S Graziano, F Petroni, G Prota, S Truffa, A Giacometti, A Costantini, V Barocci, G Angarano, L Monno, E Milano, C Suardi, V Donati, G Verucchi, F Castelnuovo, C Minardi, B Menzaghi, C Abeli, L Chessa, F Pes, B Cacopardo, B Celesia, J Vecchiet, K Falasca, A Pan, S Lorenzotti, L Sighinolfi, D Segala, P Blanc, F Vichi, G Cassola, M Bassetti, A Alessandrini, N Bobbio, G Mazzarello, M Lichtner, L Fondaco, P Bonfanti, C Molteni, A Chiodera, P Milini, G Nunnari, G Pellicanò, , G Rizzardini, E S Cannizzo, M C Moioli, R Piolini, D Bernacchia, A Poli, C Tincati, C Puzzolante, C Migliorino, G Lapadula, V Sangiovanni, G Borgia, V Esposito, G Di Flumeri, I Gentile, V Rizzo, A M Cattelan, S Marinello, A Cascio, M Trizzino, D Francisci, E Schiaroli, G Parruti, F Sozio, C Lazzaretti, R Corsini, A Antinori, A Cristaudo, V Vullo, R Acinapura, S Lamonica, M Capozzi, A Mondi, M Rivano Capparuccia, G Iaiani, A Latini, G Onnelli, M M Plazzi, G De Girolamo, M Cecchetto, F Viviani, G Madeddu, A De Vito, B Rossetti, F Montagnani, A Franco, R Fontana Del Vecchio, C Di Giuli, P Caramello, G C Orofino, M Sciandra, A Londero, V Manfrin, G Battagin, G Starnini, A Ialungo

Subjects
HBsAg, medicine.medical_specialty, Hepatitis C virus, Liver fibrosis, Human immunodeficiency virus (HIV), OBI, medicine.disease_cause, anti-HBc, HBV, HIV/HBV coinfection, liver fibrosis, Gastroenterology, Major Articles, NO, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Hiv infected patients, 030212 general & internal medicine, Hepatitis B virus, business.industry, liver fibrosi, virus diseases, Settore MED/17, digestive system diseases, Anti-HBc, HIV-HBV coinfection, HBV, Liver fibrosis, OBI, Infectious Diseases, AcademicSubjects/MED00290, HIV-HBV coinfection, Oncology, Cohort, 030211 gastroenterology & hepatology, business, Hepatic fibrosis
Abstract

Background The aim of this study was to investigate the impact of anti-HBc (HBcAb) positivity on the progression of liver fibrosis (Fibrosis-4 score >3.25) in the Italian cohort of HIV-infected individuals naïve to antiretroviral treatment (ICONA). Methods All patients with FIB-4 Results Patients who were HBcAb+/HCV-/HBs antigen (HBsAg)- and HCV+/HBcAb+/HBsAg- or HBsAg+/HBcAb+/HCV- had CD4+ cell counts below the nadir and significantly higher prevalence of AIDS diagnosis at baseline than the other groups (P < .0001). A Cox regression model adjusted for age, HIV transmission mode, country of birth, and alcohol consumption showed a higher relative risk (HR) of progression to FIB-4 >3.25 in HCV+/HBcAb+/HBsAg- patients (HR, 7.2; 95% CI, 3 8–13.64). Conclusions HBcAb+ contributes to liver damage in HIV+/HCV+/HBcAb+/HBsAg- subjects. A careful monitoring for signs of previous HBV infection is needed in this kind of patients.

Published
2021

22. Risk and predictive factors of prolonged viral RNA shedding in upper respiratory specimens in a large cohort of COVID-19 patients admitted to an Italian reference hospital

Author

Mondi, Annalisa, primary, Lorenzini, Patrizia, additional, Castilletti, Concetta, additional, Gagliardini, Roberta, additional, Lalle, Eleonora, additional, Corpolongo, Angela, additional, Valli, Maria Beatrice, additional, Taglietti, Fabrizio, additional, Cicalini, Stefania, additional, Loiacono, Laura, additional, Di Gennaro, Francesco, additional, D’Offizi, Gianpiero, additional, Palmieri, Fabrizio, additional, Nicastri, Emanuele, additional, Agrati, Chiara, additional, Petrosillo, Nicola, additional, Ippolito, Giuseppe, additional, Vaia, Francesco, additional, Girardi, Enrico, additional, Capobianchi, Maria Rosaria, additional, Antinori, Andrea, additional, Zito, Sara, additional, Abbonizio, Maria Alessandra, additional, Abdeddaim, Amina, additional, Agostini, Elisabetta, additional, Albarello, Fabrizio, additional, Amadei, Gioia, additional, Amendola, Alessandra, additional, Antonica, Maria Assunta, additional, Antonini, Mario, additional, Bartoli, Tommaso Ascoli, additional, Baldini, Francesco, additional, Barbaro, Raffaella, additional, Bartolini, Barbara, additional, Bellagamba, Rita, additional, Benigni, Martina, additional, Bevilacqua, Nazario, additional, Biava, Gianluigi, additional, Bibas, Michele, additional, Bordi, Licia, additional, Bordoni, Veronica, additional, Boumis, Evangelo, additional, Branca, Marta, additional, Buonomo, Rosanna, additional, Busso, Donatella, additional, Camici, Marta, additional, Campioni, Paolo, additional, Canichella, Flaminia, additional, Capone, Alessandro, additional, Caporale, Cinzia, additional, Caraffa, Emanuela, additional, Caravella, Ilaria, additional, Carletti, Fabrizio, additional, Cataldo, Adriana, additional, Cerilli, Stefano, additional, Cerva, Carlotta, additional, Chiappini, Roberta, additional, Chinello, Pierangelo, additional, Cianfarani, Maria Assunta, additional, Ciaralli, Carmine, additional, Cimaglia, Claudia, additional, Cinicola, Nicola, additional, Ciotti, Veronica, additional, Colavita, Francesca, additional, Cristofaro, Massimo, additional, Curiale, Salvatore, additional, D’Abramo, Alessandra, additional, Dantimi, Cristina, additional, De Angelis, Alessia, additional, De Angelis, Giada, additional, De Palo, Maria Grazia, additional, De Zottis, Federico, additional, Di Bari, Virginia, additional, Di Lorenzo, Rachele, additional, Di Stefano, Federica, additional, Donno, Davide, additional, Evangelista, Francesca, additional, Faraglia, Francesca, additional, Farina, Anna, additional, Ferraro, Federica, additional, Fiorentini, Lorena, additional, Frustaci, Andrea, additional, Fusetti, Matteo, additional, Galati, Vincenzo, additional, Gallì, Paola, additional, Garotto, Gabriele, additional, Gaviano, Ilaria, additional, Tekle, Saba Gebremeskel, additional, Giancola, Maria Letizia, additional, Giansante, Filippo, additional, Giombini, Emanuela, additional, Granata, Guido, additional, Greci, Maria Cristina, additional, Grilli, Elisabetta, additional, Grisetti, Susanna, additional, Gualano, Gina, additional, Iacomi, Fabio, additional, Iaconi, Marta, additional, Iannicelli, Giuseppina, additional, Inversi, Carlo, additional, Lamanna, Maria Elena, additional, Lanini, Simone, additional, Lapa, Daniele, additional, Lepore, Luciana, additional, Libertone, Raffaella, additional, Lionetti, Raffaella, additional, Liuzzi, Giuseppina, additional, Lucia, Andrea, additional, Lufrani, Franco, additional, Macchione, Manuela, additional, Maffongelli, Gaetano, additional, Marani, Alessandra, additional, Marchioni, Luisa, additional, Mariano, Andrea, additional, Marini, Maria Cristina, additional, Maritti, Micaela, additional, Mastrobattista, Annelisa, additional, Mastrorosa, Ilaria, additional, Matusali, Giulia, additional, Mazzotta, Valentina, additional, Mencarini, Paola, additional, Meschi, Silvia, additional, Messina, Francesco, additional, Micarelli, Sibiana, additional, Mogavero, Giulia, additional, Mondi, Annalisa, additional, Montalbano, Marzia, additional, Montaldo, Chiara, additional, Mosti, Silvia, additional, Murachelli, Silvia, additional, Musso, Maria, additional, Nardi, Michela, additional, Navarra, Assunta, additional, Nocioni, Martina, additional, Noto, Pasquale, additional, Noto, Roberto, additional, Oliva, Alessandra, additional, Onnis, Ilaria, additional, Ottou, Sandrine, additional, Palazzolo, Claudia, additional, Pallini, Emanuele, additional, Palombi, Giulio, additional, Pareo, Carlo, additional, Passeri, Virgilio, additional, Pelliccioni, Federico, additional, Penna, Giovanna, additional, Petrecchia, Antonella, additional, Petrone, Ada, additional, Pianura, Elisa, additional, Pinnetti, Carmela, additional, Pisciotta, Maria, additional, Piselli, Pierluca, additional, Pittalis, Silvia, additional, Pontarelli, Agostina, additional, Proietti, Costanza, additional, Puro, Vincenzo, additional, Ramazzini, Paolo Migliorisi, additional, Rianda, Alessia, additional, Rinonapoli, Gabriele, additional, Rosati, Silvia, additional, Rubino, Dorotea, additional, Rueca, Martina, additional, Ruggeri, Alberto, additional, Sacchi, Alessandra, additional, Sampaolesi, Alessandro, additional, Sanasi, Francesco, additional, Santagata, Carmen, additional, Scarabello, Alessandra, additional, Scarcia, Silvana, additional, Schininà, Vincenzo, additional, Scognamiglio, Paola, additional, Scorzolini, Laura, additional, Stazi, Giulia, additional, Strano, Giacomo, additional, Taibi, Chiara, additional, Taloni, Giorgia, additional, Nardi, Tetaj, additional, Tonnarini, Roberto, additional, Topino, Simone, additional, Tozzi, Martina, additional, Vairo, Francesco, additional, Vergori, Alessandra, additional, Vincenzi, Laura, additional, Visco-Comandini, Ubaldo, additional, Vita, Serena, additional, Vittozzi, Pietro, additional, Zaccarelli, Mauro, additional, and Zanetti, Antonella, additional

Published
2021
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23. Increase in Tuberculosis Diagnostic Delay during First Wave of the COVID-19 Pandemic: Data from an Italian Infectious Disease Referral Hospital

Author

Di Gennaro, Francesco, primary, Gualano, Gina, additional, Timelli, Laura, additional, Vittozzi, Pietro, additional, Di Bari, Virginia, additional, Libertone, Raffaella, additional, Cerva, Carlotta, additional, Pinnarelli, Luigi, additional, Nisii, Carla, additional, Ianniello, Stefania, additional, Mosti, Silvia, additional, Bevilacqua, Nazario, additional, Iacomi, Fabio, additional, Mondi, Annalisa, additional, Topino, Simone, additional, Goletti, Delia, additional, Vaia, Francesco, additional, Ippolito, Giuseppe, additional, Girardi, Enrico, additional, and Palmieri, Fabrizio, additional

Published
2021
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24. Plant microRNAs from Moringa oleifera Regulate Immune Response and HIV Infection

Author

Minutolo, Antonella, primary, Potestà, Marina, additional, Roglia, Valentina, additional, Cirilli, Marco, additional, Iacovelli, Federico, additional, Cerva, Carlotta, additional, Fokam, Joseph, additional, Desideri, Alessandro, additional, Andreoni, Massimo, additional, Grelli, Sandro, additional, Colizzi, Vittorio, additional, Muleo, Rosario, additional, and Montesano, Carla, additional

Published
2021
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25. Appraisal of a Simple and Effective RT-qPCR Assay for Evaluating the Reverse Transcriptase Activity in Blood Samples from HIV-1 Patients

Author

Macchi, Beatrice, primary, Frezza, Caterina, additional, Marino-Merlo, Francesca, additional, Minutolo, Antonella, additional, Stefanizzi, Valeria, additional, Balestrieri, Emanuela, additional, Cerva, Carlotta, additional, Sarmati, Loredana, additional, Andreoni, Massimo, additional, Grelli, Sandro, additional, and Mastino, Antonio, additional

Published
2020
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26. Cryptic HBV Replicative Activity Is Frequently Revealed in Anti-HBc-Positive/HBsAg-Negative Patients with HIV Infection by Highly Sensitive Molecular Assays, and Can Be Predicted by Integrating Classical and Novel Serological HBV Markers

Author

Salpini, Romina, primary, Malagnino, Vincenzo, additional, Piermatteo, Lorenzo, additional, Mulas, Tiziana, additional, Alkhatib, Mohammad, additional, Scutari, Rossana, additional, Teti, Elisabetta, additional, Cerva, Carlotta, additional, Yu La Rosa, Katia, additional, Brugneti, Marta, additional, Bertoli, Ada, additional, Rossi, Benedetta, additional, Holzmayer, Vera, additional, Gersch, Jeffrey, additional, Kuhns, Mary, additional, Cloherty, Gavin, additional, Ceccherini-Silberstein, Francesca, additional, Perno, Carlo-Federico, additional, Iannetta, Marco, additional, Andreoni, Massimo, additional, Sarmati, Loredana, additional, and Svicher, Valentina, additional

Published
2020
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27. Concurrent cavitary pulmonary tuberculosisand COVID-19 pneumonia with in vitro immune cell anergy:a case report.

Author

Musso, Maria, primary, Gennaro, Francesco Di, additional, Gualano, Gina, additional, Mosti, Silvia, additional, Cerva, Carlotta, additional, Fard, Saeid Najafi, additional, Libertone, Raffaella, additional, Bari, Virginia Di, additional, Cristofaro, Massimo, additional, Tonnarini, Roberto, additional, Goletti, Delia, additional, and Palmieri, Fabrizio, additional

Published
2020
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28. Quantitative HBeAg varies in the different phases of HBV infection, and can predict therapeutic outcome in the setting of immunosuppression driven HBV reactivation

Author

Piermatteo, Lorenzo, primary, Salpini, Romina, additional, Alkhatib, Mohammad, additional, Bertoli, Ada, additional, Iuvara, Alessandra, additional, De Cristofaro, Maria, additional, Cappiello, Giuseppina, additional, Cerva, Carlotta, additional, Minichini, Carmine, additional, Starace, Mario, additional, Pisaturo, Mariantonietta, additional, Coppola, Nicola, additional, Fontana, Carla, additional, Sarmati, Loredana, additional, Andreoni, Massimo, additional, Mario, Angelico, additional, Grelli, Sandro, additional, Silberstein, Francesca Ceccherini, additional, Perno, Carlo Federico, additional, and Svicher, Valentina, additional

Published
2020
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29. The integrated use of accurate virological and serological HBV markers can help identifying HBsAg-negative/anti-HBC-positive patients at higher risk of HBV-reactivation and optimizing the duration of prophylaxis in oncohematological setting

Author

Salpini, Romina, primary, Cerva, Carlotta, additional, Alkhatib, Mohammad, additional, Piermatteo, Lorenzo, additional, Battisti, Arianna, additional, Malagnino, Vincenzo, additional, Fabeni, Lavinia, additional, Cantonetti, Maria, additional, Arcese, William, additional, Silberstein, Francesca Ceccherini, additional, Perno, Carlo Federico, additional, Andreoni, Massimo, additional, Sarmati, Loredana, additional, and Svicher, Valentina, additional

Published
2020
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30. A Hyper-Glycosylation of HBV Surface Antigen Correlates with HBsAg-Negativity at Immunosuppression-Driven HBV Reactivation in Vivo and Hinders HBsAg Recognition In Vitro

Author

Salpini, Romina, primary, Piermatteo, Lorenzo, additional, Battisti, Arianna, additional, Colagrossi, Luna, additional, Aragri, Marianna, additional, Yu La Rosa, Katia, additional, Bertoli, Ada, additional, Saccomandi, Patrizia, additional, Lichtner, Miriam, additional, Marignani, Massimo, additional, Maylin, Sarah, additional, Delaugerre, Constance, additional, Morisco, Filomena, additional, Coppola, Nicola, additional, Marrone, Aldo, additional, Iapadre, Nerio, additional, Cerva, Carlotta, additional, Aquaro, Stefano, additional, Angelico, Mario, additional, Sarmati, Loredana, additional, Andreoni, Massimo, additional, Verheyen, Jens, additional, Ceccherini-Silberstein, Francesca, additional, Levrero, Massimo, additional, Perno, Carlo Federico, additional, Belloni, Laura, additional, and Svicher, Valentina, additional

Published
2020
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31. Key mutations in the C-terminus of the HBV surface glycoprotein correlate with lower HBsAg levels in vivo, hinder HBsAg secretion in vitro and reduce HBsAg structural stability in the setting of HBeAg-negative chronic HBV genotype-D infection

Author

Salpini, Romina, primary, Battisti, Arianna, additional, Piermatteo, Lorenzo, additional, Carioti, Luca, additional, Anastasiou, Olympia E., additional, Gill, Upkar S., additional, Di Carlo, Domenico, additional, Colagrossi, Luna, additional, Duca, Leonardo, additional, Bertoli, Ada, additional, La Rosa, Katia Yu, additional, Fabeni, Lavinia, additional, Iuvara, Alessandra, additional, Malagnino, Vincenzo, additional, Cerva, Carlotta, additional, Lichtner, Miriam, additional, Mastroianni, Claudio M., additional, De Sanctis, Giuseppe Maria, additional, Paoloni, Maurizio, additional, Marignani, Massimo, additional, Pasquazzi, Caterina, additional, Iapadre, Nerio, additional, Parruti, Giustino, additional, Vecchiet, Jacopo, additional, Sarmati, Loredana, additional, Andreoni, Massimo, additional, Angelico, Mario, additional, Grelli, Sandro, additional, T. Kennedy, Patrick, additional, Verheyen, Jens, additional, Aquaro, Stefano, additional, Ceccherini-Silberstein, Francesca, additional, Perno, Carlo Federico, additional, and Svicher, Valentina, additional

Published
2020
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32. Naïve/Effector CD4 T cell ratio as a useful predictive marker of immune reconstitution in late presenter HIV patients: A multicenter study

Author

Bordoni, Veronica, primary, Brando, Bruno, additional, Piselli, Pierluca, additional, Forini, Olindo, additional, Perna, Federico Enrico, additional, Atripaldi, Umberto, additional, Carputo, Sara, additional, Garziano, Federica, additional, Trento, Elisabetta, additional, D’Agosto, Giovanna, additional, Latini, Alessandra, additional, Colafigli, Manuela, additional, Cristaudo, Antonio, additional, Sacchi, Alessandra, additional, Andreoni, Massimo, additional, De Carli, Gabriella, additional, Orchi, Nicoletta, additional, Grelli, Sandro, additional, Gatti, Arianna, additional, Cerva, Carlotta, additional, Minutolo, Antonella, additional, Potestà, Marina, additional, Di Martino, Maria Luisa, additional, Ortu, Francesco, additional, Selva, Paola, additional, Del Pup, Laura, additional, Guarnori, Irene, additional, Lorenzini, Patrizia, additional, Capuano, Giusy, additional, Antinori, Andrea, additional, and Agrati, Chiara, additional

Published
2019
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33. HEV SEROPREVALENCE IN HIV-1 INFECTED PATIENTS IN A ROMAN HOSPITAL IS ASSOCIATED WITH OTHER VIRAL HEPATITIS COINFECTION HISTORY

Author

Yagai Bouba, Cerva, Carlotta, Piermatteo, Lorenzo, Giovinazzo, Alessandro, Malagnino, Vincenzo, Ciotti, Marco, Armenia, Daniele, Stingone, Christof, Duranti, Federica, Spalliera, Ilaria, Kenyon, Elisa, Guenci, Tania, Foroghi, Luca, Paba, Pierpaolo, Bertoli, Ada, Teti, Elisabetta, Svicher, Valentina, Sarmati, Loredana, Santoro, Maria Mercedes, Grelli, Sandro, Andreoni, Massimo, and Ceccherini-Silberstein, Francesca

Published
2019
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35. Remission of an HHV8-related extracavitary primary effusion lymphoma in an HIV-positive patient during antiretroviral treatment containing dolutegravir

Author

Campogiani, Laura, primary, Cerva, Carlotta, additional, Maffongelli, Gaetano, additional, Teti, Elisabetta, additional, Pupo, Livio, additional, Vaccarini, Sara, additional, Cantonetti, Maria, additional, Pennica, Alfredo, additional, Andreoni, Massimo, additional, and Sarmati, Loredana, additional

Published
2019
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36. SAT-190-Specific genetic elements in HBsAg C-terminus profoundly affect HBsAg levels in vivo, hamper HBsAg secretion in vitro and alter HBsAg structural stability in HBeAg-negative chronic HBV genotype D infection

Author

Piermatteo, Lorenzo, primary, Battisti, Arianna, additional, Carioti, Luca, additional, Anastasiou, Olympia, additional, Gill, Upkar S., additional, Colagrossi, Luna, additional, Bertoli, Ada, additional, Aragri, Marianna, additional, Iuvara, Alessandra, additional, Malagnino, Vincenzo, additional, Cerva, Carlotta, additional, Lichtner, Miriam, additional, Mastroianni, Claudio M., additional, Sanctis, Giuseppe Maria De, additional, Maurizio, Paoloni, additional, Marignani, Massimo, additional, Pasquazzi, Caterina, additional, Iapadre, Nerio, additional, Mari, Terenzio, additional, Parruti, Giustino, additional, Vecchiet, Jacopo, additional, Sarmati, Loredana, additional, Andreoni, Massimo, additional, Mario, Angelico, additional, Grelli, Sandro, additional, Kennedy, Patrick, additional, Verheyen, Jens, additional, Silberstein, Francesca Ceccherini, additional, Perno, Carlo Federico, additional, Svicher, Valentina, additional, and Salpini, Romina, additional

Published
2019
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37. SAT-196-The integrated use of highly sensitive HBV markers can predict HBV reactivation in HBsAg-negative/Anti-HBc positive patients from oncohematological setting

Author

Salpini, Romina, primary, Cerva, Carlotta, additional, Battisti, Arianna, additional, Piermatteo, Lorenzo, additional, Sacco, Angelica, additional, Malagnino, Vincenzo, additional, Arcese, William, additional, Cantonetti, Maria, additional, Silberstein, Francesca Ceccherini, additional, Perno, Carlo Federico, additional, Andreoni, Massimo, additional, Sarmati, Loredana, additional, and Svicher, Valentina, additional

Published
2019
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40. Awareness, discussion and non-prescribed use of HIV pre-exposure prophylaxis among persons living with HIV/AIDS in Italy: a Nationwide, cross-sectional study among patients on antiretrovirals and their treating HIV physicians

Author

Palummieri, Antonio, De Carli, Gabriella, Rosenthal, Éric, Cacoub, Patrice, Mussini, Cristina, Puro, Vincenzo, Ladisa, Nicoletta, Maggiolo, Franco, Rizzi, Marco, Calza, Leonardo, Colangeli, Vincenzo, Girometti, Nicolò, Ferraresi, Alice, Focà, Emanuele, Giorgetti, Pier Francesco, Pezzoli, Maria Chiara, Celesia, Benedetto Maurizio, Pinzone, Marilia Rita, Bruno, Tiziana, Viada, Alberto, Vitullo, Davide, Guardigni, Viola, Sighinolfi, Laura, Ambu, Silvia, Bartolozzi, Dario, Campolmi, Irene, Meli, Massimo, Pozzi, Marco, Sterrantino, Gaetana, Matarazzo, Filippo, Purificato, Francesco, Anzalone, Enza, Luciano, Sarracino, Lichtner, Miriam, Raffaella, Marocco, Mercurio, Vito Sante, Lorena, Paula Castelli, Martorelli, Paoli, Linzalone, Angela, Esoka, Franklyn, Raise, Eseme Enzo, Bossolasco, Simona, Castagna, Antonella, Cernuschi, Massimo, Cinque, Paola, Fumagalli, Luca, Gaiera, Giovanni, Gianotti, Nicola, Guffanti, Monica, Maillard, Miriam, Nozza, Silvia, Spagnuolo, Vincenzo, Uberti-Foppa, Caterina, Borghi, Vanni, Cristina Mussini, Null, Chessa, Luchino, Matta, Laura, Pasetto, Maria Cristina, D'Esposito, Giuseppe, Franco, Alfredo, Izzo, Crescenzo Maria, Manzillo, Elio, Marocco, Alessandro, Micillo, Raffaele, Pizzella, Teresa, Martini, Salvatore, Moretti, Maria Vittoria, Schiaroli, Elisabetta, Catalani, Corrado, Giorgi, Marina, Menichini, Beatrice, Trezzi, Michele, Migliore, Simona, Ballardini, Giuseppe, Barchi, Enrico, Garlassi, Elisa, Magnani, Giacomo, Prati, Francesca, Testa, Lucia, Ursitti, Maria Alessandra, Zoboli, Giuliana, Teti, Elisabetta, Buonomini, Anna Rita, Cerva, Carlotta, Giovanni D'Anna, Null, Ilari, Barbara, Malagnino, Vincenzo, Sarmati, Loredana, Ammassari, Adriana, Bellagamba, Rita, Evangelo, Boumis, Cicalini, Stefania, Liuzzi, Giuseppina, Loiacono, Laura, Migliorisi, Paolo, Nicastri, Emanuele, Pinnetti, Carmela, Sampaolesi, Alessandro, Tommasi, Chiara, Zaccarelli, Mauro, Angileri, Rosalia, Coscia, Maria, D'Ettorre, Gabriella, Fantauzzi, Alessandra, Iaiani, Giancarlo, Mezzaroma, Ivano, Paoletti, Francesca, Zaccaria, Maria, De Luca, Andrea, Rossetti, Barbara, Pomi, Manola, Carnicelli, Nicoletta, Gonnelli, Angela, Marri, Daniele, Toscano, Lucia, Armignacco, Orlando, Caterini, Anna Rita, Caterini, Antonio Luciano, Di Filippo, Barbara, Ialungo, Anna Maria, Rastrelli, Elena, Sabatini, Rita, Palummieri, A, De Carli, G, Rosenthal, É, Cacoub, P, Mussini, C, Puro, V, the PrEPventHIV Italy Study, Group, Castagna, A, Spagnuolo, V, and Uberti-Foppa, C

Subjects
0301 basic medicine, Male, Anti-HIV agents, Pediatrics, Health Knowledge, Attitudes, Practice, Cross-sectional study, Alternative medicine, Psychological intervention, Human immunodeficiency virus (HIV), HIV Infections, Self Medication, Anti-HIV agent, Logistic regression, medicine.disease_cause, Pre-exposure prophylaxis, Sexual and Gender Minorities, 0302 clinical medicine, Surveys and Questionnaires, 030212 general & internal medicine, HIV physician, Dosing regimen, virus diseases, Persons Living with HIV/AIDS (PLWHA), Infectious Diseases, Italy, HIV physicians, Female, Research Article, Adult, medicine.medical_specialty, Sexual Behavior, HIV prevention, lcsh:Infectious and parasitic diseases, 03 medical and health sciences, Acquired immunodeficiency syndrome (AIDS), Physicians, medicine, Humans, lcsh:RC109-216, Acquired Immunodeficiency Syndrome, business.industry, medicine.disease, 030112 virology, Pre-Exposure Prophylaxis (PrEP), Cross-Sectional Studies, Family medicine, Pre-Exposure Prophylaxis, business
Abstract

Background Before Pre-Exposure Prophylaxis (PrEP) was officially recommended and made available, a few surveys among gay and bisexual men, and persons living with HIV/AIDS (PLWHA), identified an informal use of antiretrovirals (ARVs) for PrEP among HIV-negative individuals. Before PrEP availability in Italy, we aimed to assess whether PLWHA in Italy shared their ARVs with HIV-negative individuals, whether they knew people who were on PrEP, and describe the level of awareness and discussion on this preventive measure among them and people in their close circle. Methods Two anonymous questionnaires investigating personal characteristics and PrEP awareness, knowledge, and experience were proposed to HIV specialists and their patients on ARVs in a one-week, cross-sectional survey (December 2013–January 2014). Among PLWHA, a Multivariable Logistic Regression analysis was conducted to identify factors associated with PrEP discussion with peers (close circle and/or HIV associations), and experience (use in close circle and/or personal ARV sharing). Results Eighty-seven specialists in 31 representative Infectious Diseases departments administered the questionnaire to 1405 PLWHA. Among specialists, 98% reported awareness, 65% knew the dosage schedule, and 14% had previously suggested or prescribed PrEP. Among PLWHA, 45.6% were somehow aware, discussed or had direct or indirect experience of PrEP: 38% “had heard” of PrEP, 24% were aware of studies in HIV-negative individuals demonstrating a risk reduction through the use of ARVs, 22% had discussed PrEP, 12% with peers; 9% reported PrEP use in close circle and 1% personal ARV sharing. Factors predictive of either PrEP discussion with peers or experience differed between men and women, but across all genders were mainly related to having access to information, with HIV association membership being the strongest predictor. Conclusions At a time and place where there were neither official information nor proposals or interventions to guide public policies on PrEP in Italy, a significant number of PLWHA were aware of it, and approximately 10% reported PrEP use in their close circle, although they rarely shared their ARVs with uninfected people for this purpose. Official policies and PrEP availability, along with implementation programs, could avoid risks from uncontrolled PrEP procurement and self-administration practices. Electronic supplementary material The online version of this article (10.1186/s12879-017-2819-5) contains supplementary material, which is available to authorized users.

Published
2017

41. Comparative evaluation of subtyping tools for surveillance of newly emerging HIV-1 strains

Author

Fabeni, Lavinia, Berno, Giulia, Fokam, Joseph, Bertoli, Ada, Alteri, Claudia, Gori, Caterina, Forbici, Federica, Takou, Desirã, Vergori, Alessandra, Zaccarelli, Mauro, Maffongelli, Gaetano, Borghi, Vanni, Latini, Alessandra, Pennica, Alfredo, Mastroianni, Claudio Maria, Montella, Francesco, Mussini, Cristina, Andreoni, Massimo, Antinori, Andrea, Perno, Carlo Federico, Santoro, Maria Mercedes, Armenia, Daniele, Bellocchi, Maria Concetta, Biddittu, Andrea, Bruni, Massimiliano, Buonomini, Anna Rita, Carioti, Luca, Ceccherini Silberstein, Francesca, Cerva, Carlotta, Cesta, Novella, Di Carlo, Domenico, Dori, Luca, Foroghi, Luca, Gentilotti, Elisa, Giannella, Sara, Guenci, Tania, Malagnino, Vincenzo, Ricciardi, Alessandra, Romani, Marzia, Salpini, Omina, Sarmati, Loredana, Scutari, Rossana, Serafini, Valentina, Sordillo, Pasquale, Stazi, Francesca, Stingone, Cristof, Svicher, Valentina, Teti, Elisabetta, Viscione, Magdalena, Abbate, Isabella, Acinapura, Rosa, Alba, Lucia, Ammassari, Adriana, Baldini, Franco, Bellagamba, Rita, Boumis, Evangelo, Capobianchi, Maria Rosaria, Carta, Stefania, Cicalini, Stefania, Continenza, Fabio, De Carli, Gabriella, D'Arrigo, Roberta, D'Offizi, Gianpiero, Fedele, Valentina, Galati, Vincenzo, Giannetti, Alberto, Girardi, Enrico, Grisetti, Susanna, Libertone, Raffaella, Liuzzi, Giuseppina, Lorenzini, Patrizia, Maddaluno, Rita, Mariano, Andrea, Navarra, Assunta, Nicastri, Emanuele, Nurra, Giuseppina, Orchi, Nicoletta, Palummieri, Antonio, Pinnetti, Carmela, Pittalis, Silvia, Pizzi, Daniele, Puro, Vincenzo, Sampaolesi, Alessandro, Sciarrone, Maria Rosaria, Scognamiglio, Paola, Sias, Catia, Visco Comandini, Ubaldo, Colafigli, Manuela, Cristaudo, Antonio, Giuliani, Massimo, Pacifici, Anna, Di Sora, Fiorella, Iebba, Filippo, Lichtner, Miriam, Marocco, Raffaella, Bernardi, Stefania, Anzalone, Enza, Bonaventura, Maria Elena, Marchili, Mauro, Pitorri, Antonella, Di Francesco, Luigi Falconi, Di Giammartino, Dante, Caterini, Antonio, Armignacco, Orlando, Mariani, Rinalda, Paoloni, Maurizio, Parruti, Giustino, Pieri, Alessandro, Sozio, Federica, Cellini, Antonio, Grimaldi, Alessandro, Mariani, Maurizio, Picchi, Giovanna, Gennari, William, Nanfack, Aubin J., Ndjolo, Alexis, and Torimiro, Judith N.

Subjects
0301 basic medicine, Microbiology (medical), Settore MED/17 - Malattie Infettive, Human immunodeficiency virus (HIV), Context (language use), HIV Infections, Biology, medicine.disease_cause, Sensitivity and Specificity, Genetic diversity, Comparative evaluation, 03 medical and health sciences, HIV Protease, Virology, Genotype, Circulating recombinant forms, HIV-1, Phylogeny, Subtypes, Subtyping automated tools, Databases, Genetic, medicine, Humans, CRFS, Automation, Laboratory, Base Sequence, Sequence Analysis, RNA, circulating recombinant forms, genetic diversity, phylogeny, subtypes, subtyping automated tools, microbiology, Gold standard (test), Subtyping, HIV Reverse Transcriptase, Molecular Typing, 030104 developmental biology, Epidemiological surveillance
Abstract

HIV-1 non-B subtypes/circulating recombinant forms (CRFs) are increasing worldwide. Since subtype identification can be clinically relevant, we assessed the added value in HIV-1 subtyping using updated molecular phylogeny (Mphy) and the performance of routinely used automated tools. Updated Mphy (2015 updated reference sequences), used as a gold standard, was performed to subtype 13,116 HIV-1 protease/reverse transcriptase sequences and then compared with previous Mphy (reference sequences until 2014) and with COMET, REGA, SCUEAL, and Stanford subtyping tools. Updated Mphy classified subtype B as the most prevalent (73.4%), followed by CRF02_AG (7.9%), C (4.6%), F1 (3.4%), A1 (2.2%), G (1.6%), CRF12_BF (1.2%), and other subtypes (5.7%). A 2.3% proportion of sequences were reassigned as different subtypes or CRFs because of misclassification by previous Mphy. Overall, the tool most concordant with updated Mphy was Stanford-v8.1 (95.4%), followed by COMET (93.8%), REGA-v3 (92.5%), Stanford-old (91.1%), and SCUEAL (85.9%). All the tools had a high sensitivity (≥98.0%) and specificity (≥95.7%) for subtype B. Regarding non-B subtypes, Stanford-v8.1 was the best tool for C, D, and F subtypes and for CRFs 01, 02, 06, 11, and 36 (sensitivity, ≥92.6%; specificity, ≥99.1%). A1 and G subtypes were better classified by COMET (92.3%) and REGA-v3 (98.6%), respectively. Our findings confirm Mphy as the gold standard for accurate HIV-1 subtyping, although Stanford-v8.1, occasionally combined with COMET or REGA-v3, represents an effective subtyping approach in clinical settings. Periodic updating of HIV-1 reference sequences is fundamental to improving subtype characterization in the context of an effective epidemiological surveillance of non-B strains.

Published
2017

42. Infectious disease ward admission positively influences P. jiroveci pneumonia (PjP) outcome: A retrospective analysis of 116 HIV-positive and HIV-negative immunocompromised patients

Author

Ricciardi, Alessandra, primary, Gentilotti, Elisa, additional, Coppola, Luigi, additional, Maffongelli, Gaetano, additional, Cerva, Carlotta, additional, Malagnino, Vincenzo, additional, Mari, Alessia, additional, Di Veroli, Ambra, additional, Berrilli, Federica, additional, Apice, Fabiana, additional, Toschi, Nicola, additional, Di Cave, David, additional, Parisi, Saverio Giuseppe, additional, Andreoni, Massimo, additional, and Sarmati, Loredana, additional

Published
2017
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43. A snapshot of virological presentation and outcome of immunosuppression‐driven HBV reactivation from real clinical practice: Evidence of a relevant risk of death and evolution from silent to chronic infection.

Author

Salpini, Romina, Battisti, Arianna, Colagrossi, Luna, Di Carlo, Domenico, Fabeni, Lavinia, Piermatteo, Lorenzo, Cerva, Carlotta, Lichtner, Miriam, Mastroianni, Claudio, Marignani, Massimo, Maylin, Sarah, Delaugerre, Constance, Morisco, Filomena, Coppola, Nicola, Marrone, Aldo, Angelico, Mario, Sarmati, Loredana, Andreoni, Massimo, Perno, Carlo‐Federico, and Ceccherini‐Silberstein, Francesca

Subjects
RITUXIMAB, LIVER failure, PHOTOGRAPHS, THERAPEUTICS, IMMUNOSUPPRESSIVE agents, TERMINALLY ill
Abstract

The study was undertaken in order to provide a snapshot from real clinical practice of virological presentation and outcome of patients developing immunosuppression‐driven HBV reactivation. Seventy patients with HBV reactivation were included (66.2% treated with rituximab, 10% with corticosteroids and 23.8% with other immunosuppressive drugs). Following HBV reactivation, patients received anti‐HBV treatment for a median (IQR) follow‐up of 31(13‐47) months. At baseline‐screening, 72.9% of patients were HBsAg‐negative and 27.1% HBsAg‐positive. About 71.4% had a diagnosis of biochemical reactivation [median (IQR) HBV DNA and ALT: 6.9 (5.4‐7.8) log IU/mL and 359 (102‐775) U/L]. Moreover, 10% of patients died from hepatic failure. Antiviral prophylaxis was documented in 57.9% and 15.7% of HBsAg‐positive and HBsAg‐negative patients at baseline‐screening (median [IQR] prophylaxis duration: 24[15‐33] and 25[17‐36] months, respectively). Notably, HBV reactivation occurred 2‐24 months after completing the recommended course of anti‐HBV prophylaxis in 35.3% of patients. By analysing treatment outcome, the cumulative probability of ALT normalization and of virological suppression was 97% and 69%, respectively. Nevertheless, in patients negative to HBsAg at baseline‐screening, only 27% returned to HBsAg‐negative status during prolonged follow‐up, suggesting the establishment of chronic infection. In conclusion, most patients received a diagnosis of HBV reactivation accompanied by high ALT and 10% died for hepatic failure, supporting the importance of strict monitoring for an early HBV reactivation diagnosis. Furthermore, HBV reactivation correlates with high risk of HBV chronicity in patients negative for HBsAg at baseline‐screening, converting a silent into a chronic infection, requiring long‐term antiviral treatment. Finally, a relevant proportion of patients experienced HBV reactivation after completing the recommended course of anti‐HBV prophylaxis, suggesting the need to reconsider proper duration of prophylaxis particularly in profound immunosuppression. [ABSTRACT FROM AUTHOR]

Published
2019
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44. Infectious disease ward admission positively influences P. jiroveci pneumonia (PjP) outcome: A retrospective analysis of 116 HIV-positive and HIV-negative immunocompromised patients

Author

Ricciardi, Alessandra, Gentilotti, Elisa, Coppola, Luigi, Maffongelli, Gaetano, Cerva, Carlotta, Malagnino, Vincenzo, Mari, Alessia, Di Veroli, Ambra, Berrilli, Federica, Apice, Fabiana, Toschi, Nicola, Di Cave, David, Parisi, Saverio Giuseppe, Andreoni, Massimo, and Sarmati, Loredana

Subjects
Medicine and Health Sciences, Infectious Diseases, Pulmonology, Respiratory Infections, Pneumonia, Public and Occupational Health, Preventive Medicine, Prophylaxis, Biology and Life Sciences, Microbiology, Medical Microbiology, Microbial Pathogens, Viral Pathogens, Immunodeficiency Viruses, HIV, Pathology and Laboratory Medicine, Pathogens, Organisms, Viruses, Biology and life sciences, RNA viruses, Retroviruses, Lentivirus, Hematology, Surgical and Invasive Medical Procedures, Transplantation, Organ Transplantation, Lung Transplantation, Respiratory System Procedures, Mathematical and Statistical Techniques, Statistical Methods, Multivariate Analysis, Physical Sciences, Mathematics, Statistics (Mathematics)
Abstract

P. jiroveci (Pj) causes a potentially fatal pneumonia in immunocompromised patients and the factors associated with a bad outcome are poorly understood. A retrospective analysis on Pj pneumonia (PjP) cases occurring in Tor Vergata University Hospital, Italy, during the period 2011–2015. The patients’ demographic, clinical and radiological characteristics and the Pj genotypes were considered. The study population included 116 patients, 37.9% of whom had haematological malignancy or underwent haematological stem cell transplantation (HSCT), 22.4% had HIV infection, 16.4% had chronic lung diseases (CLD), 7.8% had a solid cancer, and 3.4% underwent a solid organ transplant (SOT). The remaining 12.1% had a miscellaneous other condition. At univariate analysis, being older than 60 years was significantly correlated with a severe PjP (OR [95%CI] 2.52 [0.10–5.76]; p = 0.031) and death (OR [95%CI] 2.44 [1.05–5.70]; p = 0.036), while a previous trimethoprim/sulfamethoxazole (TMP/SMX) prophylaxis were significantly associated with a less severe pneumonia (OR[95%CI] 0.35 [0.15–0.84], p = 0.023); moreover, death due to PjP was significantly more frequent in patients with CLD (OR[95%CI] 3.26 [1.17–9.05]; p = 0.019) while, admission to the Infectious Diseases Unit was significantly associated with fewer deaths (OR[95%CI] 0.10 [0.03–0.36], p = 0.002). At multivariate analysis, a better PjP outcome was observed in patients taking TMP/SMX prophylaxis and that were admitted to the Infectious Diseases Unit (OR[95%CI] 0.27 [0.07–1.03], p = 0.055, OR[95%CI] 0.16 [0.05–0.55]; p = 0.004, respectively). In conclusion, in our study population, TMP/SMX prophylaxis and infectious disease specialist approach were variables correlated with a better PjP outcome.

Published
2017
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45. Increased Association of Pulmonary Thromboembolism and Tuberculosis during COVID-19 Pandemic: Data from an Italian Infectious Disease Referral Hospital.

Author

Di Bari, Virginia, Gualano, Gina, Musso, Maria, Libertone, Raffaella, Nisii, Carla, Ianniello, Stefania, Mosti, Silvia, Mastrobattista, Annelisa, Cerva, Carlotta, Bevilacqua, Nazario, Iacomi, Fabio, Mondi, Annalisa, Topino, Simone, Goletti, Delia, Girardi, Enrico, and Palmieri, Fabrizio

Subjects
TUBERCULOSIS, PULMONARY embolism, COMMUNICABLE diseases, COVID-19 pandemic, ADULT respiratory distress syndrome, CHEST pain
Abstract

Pulmonary thromboembolism (PTE) has been associated with tuberculosis (TB), but the true incidence is unknown. The aim of our study was to retrospectively evaluate the PTE prevalence in TB patients hospitalized at the National Institute for Infectious Diseases L. Spallanzani during the January 2016–December 2021 period. Retrospective data collection and evaluation were conducted. Among 1801 TB patients, 29 (1.61%) exhibited PTE. Twenty (69%) had comorbidities; eleven (37.9%) had predisposing factors for PTE. Nineteen (65.5%) had extensive TB disease. The commonest respiratory symptoms were cough (37.9%), dyspnea (31%), chest pain (10.3%), and hemoptysis (6.9%). Twenty-five (86.2%) had elevated serum D-dimer levels. An increased prevalence of PTE from 0.6% in the pre-COVID-19 pandemic period to 4.6% in the pandemic period was found. Acute respiratory failure and extensive TB disease increased significantly in the pandemic period. The increase in PTE could be explained by the increased severity of TB in patients in the pandemic period and by increased clinical suspicion and, consequently, increased requests for D-dimer testing, including in patients with non-COVID-19 pneumonia. Patients with extensive pulmonary disease are at high risk of developing PTE. Clinicians should be aware of this potentially life-threatening complication of TB, and patients should receive a thromboembolism risk assessment. [ABSTRACT FROM AUTHOR]

Published
2022
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46. FRI396 - The integrated use of accurate virological and serological HBV markers can help identifying HBsAg-negative/anti-HBC-positive patients at higher risk of HBV-reactivation and optimizing the duration of prophylaxis in oncohematological setting.

Author

Salpini, Romina, Cerva, Carlotta, Alkhatib, Mohammad, Piermatteo, Lorenzo, Battisti, Arianna, Malagnino, Vincenzo, Fabeni, Lavinia, Cantonetti, Maria, Arcese, William, Silberstein, Francesca Ceccherini, Perno, Carlo Federico, Andreoni, Massimo, Sarmati, Loredana, and Svicher, Valentina

Subjects
*VIRAL hepatitis, *HEPATITIS B
Published
2020
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47. HBeAg Levels Vary across the Different Stages of HBV Infection According to the Extent of Immunological Pressure and Are Associated with Therapeutic Outcome in the Setting of Immunosuppression-Driven HBV Reactivation

Author

Carla Fontana, Patrick T F Kennedy, Elisa Basile, Carlotta Cerva, Valentina Svicher, Maria De Cristofaro, A. Iuvara, L. Piermatteo, Stefano D’Anna, Francesca Ceccherini-Silberstein, Mariantonietta Pisaturo, Loredana Sarmati, Carmine Minichini, Mohammad Alkhatib, Mario Starace, Romina Salpini, Eleonora Andreassi, Sandro Grelli, Massimo Andreoni, Upkar S. Gill, Ada Bertoli, Vincenzo Malagnino, Nicola Coppola, Giuseppina Cappiello, Piermatteo, Lorenzo, Alkhatib, Mohammad, D'Anna, Stefano, Malagnino, Vincenzo, Bertoli, Ada, Andreassi, Eleonora, Basile, Elisa, Iuvara, Alessandra, De Cristofaro, Maria, Cappiello, Giuseppina, Cerva, Carlotta, Minichini, Carmine, Pisaturo, Mariantonietta, Starace, Mario, Coppola, Nicola, Fontana, Carla, Grelli, Sandro, Ceccherini-Silberstein, Francesca, Andreoni, Massimo, Gill, Upkar S, Kennedy, Patrick T F, Sarmati, Loredana, Salpini, Romina, Svicher, Valentina, Piermatteo, L., Alkhatib, M., D'Anna, S., Malagnino, V., Bertoli, A., Andreassi, E., Basile, E., Iuvara, A., De Cristofaro, M., Cappiello, G., Cerva, C., Minichini, C., Pisaturo, M., Starace, M., Coppola, N., Fontana, C., Grelli, S., Ceccherini-Silberstein, F., Andreoni, M., Gill, U. S., Kennedy, P. T. F., Sarmati, L., Salpini, R., and Svicher, V.

Subjects
Treatment response, medicine.medical_specialty, HBsAg, QH301-705.5, medicine.medical_treatment, viruses, Hbv reactivation, HBV reactivation, Medicine (miscellaneous), HBeAg, Gastroenterology, General Biochemistry, Genetics and Molecular Biology, Article, Internal medicine, medicine, HBV, Biology (General), Natural course, business.industry, virus diseases, Immunosuppression, cccDNA, Settore MED/17, digestive system diseases, Chronic infection, business
Abstract

HBeAg is a marker of HBV-activity, and HBeAg-loss predicts a favorable clinical outcome. Here, we characterize HBeAg-levels across different phases of HBV infection, their correlation with virological/biochemical markers and the virological response to anti-HBV therapy. Quantitative HBeAg (qHBeAg, DiaSorin) is assessed in 101 HBeAg+ patients: 20 with acute-infection, 20 with chronic infection, 32 with chronic hepatitis and 29 with immunosuppression-driven HBV-reactivation (HBV-R). A total of 15/29 patients with HBV-R are monitored for &gt, 12 months after starting TDF/ETV. qHBeAg is higher in immunosuppression-driven HBV-R (median[IQR]:930[206–1945]PEIU/mL) and declines in chronic hepatitis (481[28–1393]PEIU/mL, p = 0.03), suggesting HBeAg production, modulated by the extent of immunological pressure. This is reinforced by the negative correlation between qHBeAg and ALT in acute infection (Rho = −0.66, p = 0.006) and chronic hepatitis (Rho = −0.35, p = 0.05). Interestingly, qHBeAg strongly and positively correlates with qHBsAg across the study groups, suggesting cccDNA as a major source of both proteins in the setting of HBeAg positivity (with limited contribution of integrated HBV-DNA to HBsAg production). Focusing on 15 patients with HBV-R starting TDF/ETV, virological suppression and HBeAg-loss are achieved in 60% and 53.3%. Notably, the combination of qHBeAg &gt, 2000 PEIU/mL + qHBsAg &gt, 52,000 IU/mL at HBV-R is the only factor predicting no HBeAg loss (HBeAg loss: 0% with vs. 72.7% without qHBeAg &gt, 52,000 IU/mL, p = 0.03). In conclusion, qHBeAg varies over the natural course of HBV infection, according to the extent of immunological pressure. In the setting of HBV-R, qHBeAg could be useful in predicting the treatment response under immunosuppression.

Published
2021

48. A hyper-glycosylation of HBV surface antigen correlates with HBsAg-Negativity at immunosuppression-driven HBV reactivation in vivo and hinders HBsAg recognition in vitro

Author

Francesca Ceccherini-Silberstein, Carlotta Cerva, Ada Bertoli, Carlo Federico Perno, Massimo Marignani, Miriam Lichtner, Aldo Marrone, L. Colagrossi, Jens Verheyen, Valentina Svicher, Katia Yu La Rosa, N. Iapadre, Constance Delaugerre, L. Piermatteo, Massimo Levrero, Sarah Maylin, Marianna Aragri, Nicola Coppola, Loredana Sarmati, Stefano Aquaro, A. Battisti, Romina Salpini, Laura Belloni, Massimo Andreoni, Mario Angelico, Patrizia Saccomandi, Filomena Morisco, Salpini, R., Piermatteo, L., Battisti, A., Colagrossi, L., Aragri, M., Rosa, K. Y. L., Bertoli, A., Saccomandi, P., Lichtner, M., Marignani, M., Maylin, S., Delaugerre, C., Morisco, F., Coppola, N., Marrone, A., Iapadre, N., Cerva, C., Aquaro, S., Angelico, M., Sarmati, L., Andreoni, M., Verheyen, J., Ceccherini-Silberstein, F., Levrero, M., Perno, C. F., Belloni, L., Svicher, V., Salpini, Romina, Piermatteo, Lorenzo, Battisti, Arianna, Colagrossi, Luna, Aragri, Marianna, Yu La Rosa, Katia, Bertoli, Ada, Saccomandi, Patrizia, Lichtner, Miriam, Marignani, Massimo, Maylin, Sarah, Delaugerre, Constance, Morisco, Filomena, Coppola, Nicola, Marrone, Aldo, Iapadre, Nerio, Cerva, Carlotta, Aquaro, Stefano, Angelico, Mario, Sarmati, Loredana, Andreoni, Massimo, Verheyen, Jen, Ceccherini-Silberstein, Francesca, Levrero, Massimo, Federico Perno, Carlo, Belloni, Laura, and Svicher, Valentina

Subjects
0301 basic medicine, Male, HBsAg, Glycosylation, lcsh:QR1-502, Medizin, medicine.disease_cause, lcsh:Microbiology, HBV, HBV reactivation, N-linked glycosylation, 0302 clinical medicine, biology, virus diseases, Middle Aged, Infectious Diseases, 030211 gastroenterology & hepatology, Female, Antibody, Hepatitis B virus, Article, Cell Line, 03 medical and health sciences, Antigen, In vivo, Virology, medicine, Humans, Hepatitis B Antibodies, Aged, Immune Evasion, Hepatitis, Immunosuppression Therapy, Hepatitis B Surface Antigens, business.industry, medicine.disease, In vitro, Settore MED/17, digestive system diseases, 030104 developmental biology, Reinfection, Mutation, biology.protein, Virus Activation, business
Abstract

Immune-suppression driven Hepatitis B Virus (HBV)-reactivation poses serious concerns since it occurs in several clinical settings and can result in severe forms of hepatitis. Previous studies showed that HBV strains, circulating in patients with HBV-reactivation, are characterized by an enrichment of immune-escape mutations in HBV surface antigen (HBsAg). Here, we focused on specific immune-escape mutations associated with the acquisition of N-linked glycosylation sites in HBsAg (NLGSs). In particular, we investigated profiles of NLGSs in 47 patients with immunosuppression-driven HBV-reactivation and we evaluated their impact on HBsAg-antigenicity and HBV-replication in vitro. At HBV-reactivation, despite a median serum HBV-DNA of 6.7 [5.3&ndash, 8.0] logIU/mL, 23.4% of patients remained HBsAg-negative. HBsAg-negativity at HBV-reactivation correlated with the presence of &gt, 1 additional NLGSs (p &lt, 0.001). These NLGSs are located in the major hydrophilic region of HBsAg (known to be the target of antibodies) and resulted from the single mutation T115N, T117N, T123N, N114ins, and from the triple mutant S113N+T131N+M133T. In vitro, NLGSs strongly alter HBsAg antigenic properties and recognition by antibodies used in assays for HBsAg-quantification without affecting HBsAg-secretion and other parameters of HBV-replication. In conclusion, additional NLGSs correlate with HBsAg-negativity despite HBV-reactivation, and hamper HBsAg-antigenicity in vitro, supporting the role of NGSs in immune-escape and the importance of HBV-DNA for a proper diagnosis of HBV-reactivation.

Published
2020

49. FRI402 - Quantitative HBeAg varies in the different phases of HBV infection, and can predict therapeutic outcome in the setting of immunosuppression driven HBV reactivation.

Author

Piermatteo, Lorenzo, Salpini, Romina, Alkhatib, Mohammad, Bertoli, Ada, Iuvara, Alessandra, De Cristofaro, Maria, Cappiello, Giuseppina, Cerva, Carlotta, Minichini, Carmine, Starace, Mario, Pisaturo, Mariantonietta, Coppola, Nicola, Fontana, Carla, Sarmati, Loredana, Andreoni, Massimo, Mario, Angelico, Grelli, Sandro, Silberstein, Francesca Ceccherini, Perno, Carlo Federico, and Svicher, Valentina

Subjects
*IMMUNOSUPPRESSION, *INFECTION, *VIRAL hepatitis, *HEPATITIS B
Published
2020
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50. HBcAb Positivity Increases the Risk of Severe Hepatic Fibrosis Development in HIV/HCV-Positive Subjects From the ICONA Italian Cohort of HIV-Infected Patients.

Author

Malagnino V, Cerva C, Cingolani A, Ceccherini-Silberstein F, Vergori A, Cuomo G, Perno CF, Puoti M, d'Arminio Monforte A, Cozzi-Lepri A, Andreoni M, and Sarmati L

Abstract

Background: The aim of this study was to investigate the impact of anti-HBc (HBcAb) positivity on the progression of liver fibrosis (Fibrosis-4 score >3.25) in the Italian cohort of HIV-infected individuals naïve to antiretroviral treatment (ICONA)., Methods: All patients with FIB-4 <3.25 at baseline were evaluated prospectively: 6966 people with HIV (PWH) were screened and classified based on hepatitis B virus (HBV) and hepatitis C virus (HCV) serology., Results: Patients who were HBcAb+/HCV-/HBs antigen (HBsAg)- and HCV+/HBcAb+/HBsAg- or HBsAg+/HBcAb+/HCV- had CD4+ cell counts below the nadir and significantly higher prevalence of AIDS diagnosis at baseline than the other groups ( P < .0001). A Cox regression model adjusted for age, HIV transmission mode, country of birth, and alcohol consumption showed a higher relative risk (HR) of progression to FIB-4 >3.25 in HCV+/HBcAb+/HBsAg- patients (HR, 7.2; 95% CI, 3 8-13.64)., Conclusions: HBcAb+ contributes to liver damage in HIV+/HCV+/HBcAb+/HBsAg- subjects. A careful monitoring for signs of previous HBV infection is needed in this kind of patients., (© The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America.)

Published
2020
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