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441 results on '"Cesarini, David"'

1. Genetic architecture reconciles linkage and association studies of complex traits

Author

Sidorenko, Julia, Couvy-Duchesne, Baptiste, Kemper, Kathryn E., Moen, Gunn-Helen, Bhatta, Laxmi, Åsvold, Bjørn Olav, Mägi, Reedik, Ani, Alireza, Wang, Rujia, Nolte, Ilja M., Gordon, Scott, Hayward, Caroline, Campbell, Archie, Benjamin, Daniel J., Cesarini, David, Evans, David M., Goddard, Michael E., Haley, Chris S., Porteous, David, Medland, Sarah E., Martin, Nicholas G., Snieder, Harold, Metspalu, Andres, Hveem, Kristian, Brumpton, Ben, Visscher, Peter M., and Yengo, Loic

Published
2024
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2. Mendelian imputation of parental genotypes improves estimates of direct genetic effects

Author

Young, Alexander I, Nehzati, Seyed Moeen, Benonisdottir, Stefania, Okbay, Aysu, Jayashankar, Hariharan, Lee, Chanwook, Cesarini, David, Benjamin, Daniel J, Turley, Patrick, and Kong, Augustine

Subjects
Biological Sciences, Genetics, Human Genome, Aetiology, 2.1 Biological and endogenous factors, Generic health relevance, Genome-Wide Association Study, Genotype, Humans, Parents, Polymorphism, Single Nucleotide, Software, Medical and Health Sciences, Developmental Biology, Agricultural biotechnology, Bioinformatics and computational biology
Abstract

Effects estimated by genome-wide association studies (GWASs) include effects of alleles in an individual on that individual (direct genetic effects), indirect genetic effects (for example, effects of alleles in parents on offspring through the environment) and bias from confounding. Within-family genetic variation is random, enabling unbiased estimation of direct genetic effects when parents are genotyped. However, parental genotypes are often missing. We introduce a method that imputes missing parental genotypes and estimates direct genetic effects. Our method, implemented in the software package snipar (single-nucleotide imputation of parents), gives more precise estimates of direct genetic effects than existing approaches. Using 39,614 individuals from the UK Biobank with at least one genotyped sibling/parent, we estimate the correlation between direct genetic effects and effects from standard GWASs for nine phenotypes, including educational attainment (r = 0.739, standard error (s.e.) = 0.086) and cognitive ability (r = 0.490, s.e. = 0.086). Our results demonstrate substantial confounding bias in standard GWASs for some phenotypes.

Published
2022

3. Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals

Author

Okbay, Aysu, Wu, Yeda, Wang, Nancy, Jayashankar, Hariharan, Bennett, Michael, Nehzati, Seyed Moeen, Sidorenko, Julia, Kweon, Hyeokmoon, Goldman, Grant, Gjorgjieva, Tamara, Jiang, Yunxuan, Hicks, Barry, Tian, Chao, Hinds, David A, Ahlskog, Rafael, Magnusson, Patrik KE, Oskarsson, Sven, Hayward, Caroline, Campbell, Archie, Porteous, David J, Freese, Jeremy, Herd, Pamela, Watson, Chelsea, Jala, Jonathan, Conley, Dalton, Koellinger, Philipp D, Johannesson, Magnus, Laibson, David, Meyer, Michelle N, Lee, James J, Kong, Augustine, Yengo, Loic, Cesarini, David, Turley, Patrick, Visscher, Peter M, Beauchamp, Jonathan P, Benjamin, Daniel J, and Young, Alexander I

Subjects
Human Genome, Genetics, Pediatric, Aetiology, 2.1 Biological and endogenous factors, Genome-Wide Association Study, Humans, Multifactorial Inheritance, Polymorphism, Single Nucleotide, 23andMe Research Team, Social Science Genetic Association Consortium, Biological Sciences, Medical and Health Sciences, Developmental Biology
Abstract

We conduct a genome-wide association study (GWAS) of educational attainment (EA) in a sample of ~3 million individuals and identify 3,952 approximately uncorrelated genome-wide-significant single-nucleotide polymorphisms (SNPs). A genome-wide polygenic predictor, or polygenic index (PGI), explains 12-16% of EA variance and contributes to risk prediction for ten diseases. Direct effects (i.e., controlling for parental PGIs) explain roughly half the PGI's magnitude of association with EA and other phenotypes. The correlation between mate-pair PGIs is far too large to be consistent with phenotypic assortment alone, implying additional assortment on PGI-associated factors. In an additional GWAS of dominance deviations from the additive model, we identify no genome-wide-significant SNPs, and a separate X-chromosome additive GWAS identifies 57.

Published
2022

4. Resource profile and user guide of the Polygenic Index Repository

Author

Becker, Joel, Burik, Casper AP, Goldman, Grant, Wang, Nancy, Jayashankar, Hariharan, Bennett, Michael, Belsky, Daniel W, Karlsson Linnér, Richard, Ahlskog, Rafael, Kleinman, Aaron, Hinds, David A, Caspi, Avshalom, Corcoran, David L, Moffitt, Terrie E, Poulton, Richie, Sugden, Karen, Williams, Benjamin S, Harris, Kathleen Mullan, Steptoe, Andrew, Ajnakina, Olesya, Milani, Lili, Esko, Tõnu, Iacono, William G, McGue, Matt, Magnusson, Patrik KE, Mallard, Travis T, Harden, K Paige, Tucker-Drob, Elliot M, Herd, Pamela, Freese, Jeremy, Young, Alexander, Beauchamp, Jonathan P, Koellinger, Philipp D, Oskarsson, Sven, Johannesson, Magnus, Visscher, Peter M, Meyer, Michelle N, Laibson, David, Cesarini, David, Benjamin, Daniel J, Turley, Patrick, and Okbay, Aysu

Subjects
Epidemiology, Health Sciences, 2.6 Resources and infrastructure (aetiology), Aetiology, Data Analysis, Databases, Genetic, Genome-Wide Association Study, Humans, Multifactorial Inheritance, Polymorphism, Single Nucleotide, Polygenic score, Polygenic index, Repository, Measurement error, 23andMe Research Group, Biomedical and clinical sciences, Health sciences, Psychology
Abstract

Polygenic indexes (PGIs) are DNA-based predictors. Their value for research in many scientific disciplines is growing rapidly. As a resource for researchers, we used a consistent methodology to construct PGIs for 47 phenotypes in 11 datasets. To maximize the PGIs' prediction accuracies, we constructed them using genome-wide association studies-some not previously published-from multiple data sources, including 23andMe and UK Biobank. We present a theoretical framework to help interpret analyses involving PGIs. A key insight is that a PGI can be understood as an unbiased but noisy measure of a latent variable we call the 'additive SNP factor'. Regressions in which the true regressor is this factor but the PGI is used as its proxy therefore suffer from errors-in-variables bias. We derive an estimator that corrects for the bias, illustrate the correction, and make a Python tool for implementing it publicly available.

Published
2021

5. Problems with Using Polygenic Scores to Select Embryos

Author

Turley, Patrick, Meyer, Michelle N, Wang, Nancy, Cesarini, David, Hammonds, Evelynn, Martin, Alicia R, Neale, Benjamin M, Rehm, Heidi L, Wilkins-Haug, Louise, Benjamin, Daniel J, Hyman, Steven, Laibson, David, and Visscher, Peter M

Subjects
Reproductive Medicine, Biomedical and Clinical Sciences, Aging, Educational Status, Embryo, Mammalian, Fertilization in Vitro, Gene-Environment Interaction, Genetic Testing, Genetic Variation, Genome-Wide Association Study, Humans, Multifactorial Inheritance, Phenotype, Predictive Value of Tests, Preimplantation Diagnosis, Medical and Health Sciences, General & Internal Medicine, Biomedical and clinical sciences, Health sciences
Abstract

Companies have recently begun to sell a new service to patients considering in vitro fertilization: embryo selection based on polygenic scores (ESPS). These scores represent individualized predictions of health and other outcomes derived from genomewide association studies in adults to partially predict these outcomes. This article includes a discussion of many factors that lower the predictive power of polygenic scores in the context of embryo selection and quantifies these effects for a variety of clinical and nonclinical traits. Also discussed are potential unintended consequences of ESPS (including selecting for adverse traits, altering population demographics, exacerbating inequalities in society, and devaluing certain traits). Recommendations for the responsible communication about ESPS by practitioners are provided, and a call for a society-wide conversation about this technology is made. (Funded by the National Institute on Aging and others.).

Published
2021

6. Genomic analysis of diet composition finds novel loci and associations with health and lifestyle

Author

Meddens, S Fleur W, de Vlaming, Ronald, Bowers, Peter, Burik, Casper AP, Linnér, Richard Karlsson, Lee, Chanwook, Okbay, Aysu, Turley, Patrick, Rietveld, Cornelius A, Fontana, Mark Alan, Ghanbari, Mohsen, Imamura, Fumiaki, McMahon, George, van der Most, Peter J, Voortman, Trudy, Wade, Kaitlin H, Anderson, Emma L, Braun, Kim VE, Emmett, Pauline M, Esko, Tonũ, Gonzalez, Juan R, Kiefte-de Jong, Jessica C, Langenberg, Claudia, Luan, Jian’an, Muka, Taulant, Ring, Susan, Rivadeneira, Fernando, Snieder, Harold, van Rooij, Frank JA, Wolffenbuttel, Bruce HR, Smith, George Davey, Franco, Oscar H, Forouhi, Nita G, Ikram, M Arfan, Uitterlinden, Andre G, van Vliet-Ostaptchouk, Jana V, Wareham, Nick J, Cesarini, David, Harden, K Paige, Lee, James J, Benjamin, Daniel J, Chow, Carson C, and Koellinger, Philipp D

Subjects
Biomedical and Clinical Sciences, Nutrition and Dietetics, Prevention, Behavioral and Social Science, Genetics, Obesity, Human Genome, Nutrition, Diabetes, Aetiology, 2.1 Biological and endogenous factors, Cardiovascular, Metabolic and endocrine, Body Mass Index, Diabetes Mellitus, Type 2, Diet, Genome-Wide Association Study, Genomics, Humans, Life Style, 23andMe Research Team, EPIC- InterAct Consortium, Lifelines Cohort Study, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry, Clinical sciences, Biological psychology, Clinical and health psychology
Abstract

We conducted genome-wide association studies (GWAS) of relative intake from the macronutrients fat, protein, carbohydrates, and sugar in over 235,000 individuals of European ancestries. We identified 21 unique, approximately independent lead SNPs. Fourteen lead SNPs are uniquely associated with one macronutrient at genome-wide significance (P

Published
2021

7. Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus

Author

Mathieson, Iain, Day, Felix R., Barban, Nicola, Tropf, Felix C., Brazel, David M., Vaez, Ahmad, van Zuydam, Natalie, Bitarello, Bárbara D., Gardner, Eugene J., Akimova, Evelina T., Azad, Ajuna, Bergmann, Sven, Bielak, Lawrence F., Boomsma, Dorret I., Bosak, Kristina, Brumat, Marco, Buring, Julie E., Cesarini, David, Chasman, Daniel I., Chavarro, Jorge E., Cocca, Massimiliano, Concas, Maria Pina, Davey Smith, George, Davies, Gail, Deary, Ian J., Esko, Tõnu, Faul, Jessica D., Franco, Oscar, Ganna, Andrea, Gaskins, Audrey J., Gelemanovic, Andrea, de Geus, Eco J. C., Gieger, Christian, Girotto, Giorgia, Gopinath, Bamini, Grabe, Hans Jörgen, Gunderson, Erica P., Hayward, Caroline, He, Chunyan, van Heemst, Diana, Hill, W. David, Hoffmann, Eva R., Homuth, Georg, Hottenga, Jouke Jan, Huang, Hongyang, Hyppӧnen, Elina, Ikram, M. Arfan, Jansen, Rick, Johannesson, Magnus, Kamali, Zoha, Kardia, Sharon L. R., Kavousi, Maryam, Kifley, Annette, Kiiskinen, Tuomo, Kraft, Peter, Kühnel, Brigitte, Langenberg, Claudia, Liew, Gerald, Lind, Penelope A., Luan, Jian’an, Mägi, Reedik, Magnusson, Patrik K. E., Mahajan, Anubha, Martin, Nicholas G., Mbarek, Hamdi, McCarthy, Mark I., McMahon, George, Medland, Sarah E., Meitinger, Thomas, Metspalu, Andres, Mihailov, Evelin, Milani, Lili, Missmer, Stacey A., Mitchell, Paul, Møllegaard, Stine, Mook-Kanamori, Dennis O., Morgan, Anna, van der Most, Peter J., de Mutsert, Renée, Nauck, Matthias, Nolte, Ilja M., Noordam, Raymond, Penninx, Brenda W. J. H., Peters, Annette, Peyser, Patricia A., Polašek, Ozren, Power, Chris, Pribisalic, Ajka, Redmond, Paul, Rich-Edwards, Janet W., Ridker, Paul M., Rietveld, Cornelius A., Ring, Susan M., Rose, Lynda M., Rueedi, Rico, Shukla, Vallari, Smith, Jennifer A., Stankovic, Stasa, Stefánsson, Kári, Stöckl, Doris, Strauch, Konstantin, Swertz, Morris A., Teumer, Alexander, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Thurik, A. Roy, Timpson, Nicholas J., Turman, Constance, Uitterlinden, André G., Waldenberger, Melanie, Wareham, Nicholas J., Weir, David R., Willemsen, Gonneke, Zhao, Jing Hau, Zhao, Wei, Zhao, Yajie, Snieder, Harold, den Hoed, Marcel, Ong, Ken K., Mills, Melinda C., and Perry, John R. B.

Published
2023
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11. Multi-trait analysis of genome-wide association summary statistics using MTAG

Author

Turley, Patrick, Walters, Raymond K, Maghzian, Omeed, Okbay, Aysu, Lee, James J, Fontana, Mark Alan, Nguyen-Viet, Tuan Anh, Wedow, Robbee, Zacher, Meghan, Furlotte, Nicholas A, 23andMe Research Team, Social Science Genetic Association Consortium, Magnusson, Patrik, Oskarsson, Sven, Johannesson, Magnus, Visscher, Peter M, Laibson, David, Cesarini, David, Neale, Benjamin M, and Benjamin, Daniel J

Subjects
Biological Sciences, Genetics, Human Genome, Algorithms, Data Interpretation, Statistical, Datasets as Topic, Depression, Diagnostic Self Evaluation, Genetic Association Studies, Genome-Wide Association Study, Health, Humans, Meta-Analysis as Topic, Multifactorial Inheritance, Neuroticism, Phenotype, Polymorphism, Single Nucleotide, Quantitative Trait Loci, 23andMe Research Team, Social Science Genetic Association Consortium, Medical and Health Sciences, Developmental Biology, Agricultural biotechnology, Bioinformatics and computational biology
Abstract

We introduce multi-trait analysis of GWAS (MTAG), a method for joint analysis of summary statistics from genome-wide association studies (GWAS) of different traits, possibly from overlapping samples. We apply MTAG to summary statistics for depressive symptoms (N eff = 354,862), neuroticism (N = 168,105), and subjective well-being (N = 388,538). As compared to the 32, 9, and 13 genome-wide significant loci identified in the single-trait GWAS (most of which are themselves novel), MTAG increases the number of associated loci to 64, 37, and 49, respectively. Moreover, association statistics from MTAG yield more informative bioinformatics analyses and increase the variance explained by polygenic scores by approximately 25%, matching theoretical expectations.

Published
2018

12. Redefine statistical significance.

Author

Benjamin, Daniel J, Berger, James O, Johannesson, Magnus, Nosek, Brian A, Wagenmakers, E-J, Berk, Richard, Bollen, Kenneth A, Brembs, Björn, Brown, Lawrence, Camerer, Colin, Cesarini, David, Chambers, Christopher D, Clyde, Merlise, Cook, Thomas D, De Boeck, Paul, Dienes, Zoltan, Dreber, Anna, Easwaran, Kenny, Efferson, Charles, Fehr, Ernst, Fidler, Fiona, Field, Andy P, Forster, Malcolm, George, Edward I, Gonzalez, Richard, Goodman, Steven, Green, Edwin, Green, Donald P, Greenwald, Anthony G, Hadfield, Jarrod D, Hedges, Larry V, Held, Leonhard, Hua Ho, Teck, Hoijtink, Herbert, Hruschka, Daniel J, Imai, Kosuke, Imbens, Guido, Ioannidis, John PA, Jeon, Minjeong, Jones, James Holland, Kirchler, Michael, Laibson, David, List, John, Little, Roderick, Lupia, Arthur, Machery, Edouard, Maxwell, Scott E, McCarthy, Michael, Moore, Don A, Morgan, Stephen L, Munafó, Marcus, Nakagawa, Shinichi, Nyhan, Brendan, Parker, Timothy H, Pericchi, Luis, Perugini, Marco, Rouder, Jeff, Rousseau, Judith, Savalei, Victoria, Schönbrodt, Felix D, Sellke, Thomas, Sinclair, Betsy, Tingley, Dustin, Van Zandt, Trisha, Vazire, Simine, Watts, Duncan J, Winship, Christopher, Wolpert, Robert L, Xie, Yu, Young, Cristobal, Zinman, Jonathan, and Johnson, Valen E

Subjects
Data Interpretation, Statistical, Models, Statistical, Reproducibility of Results, Scholarly Communication
Abstract

We propose to change the default P-value threshold for statistical significance for claims of new discoveries from 0.05 to 0.005.

Published
2018

16. The Promises and Pitfalls of Genoeconomics

Author

Benjamin, Daniel J., Cesarini, David, Chabris, Christopher F., Glaeser, Edward L., Laibson, David I., Guðnason, Vilmundur, Harris, Tamara B., Launer, Lenore J., Purcell, Shaun, Smith, Albert Vernon, Johannesson, Magnus, Magnusson, Patrik K.E., Beauchamp, Jonathan P., Christakis, Nicholas A., Atwood, Craig S., Hebert, Benjamin, Freese, Jeremy, Hauser, Robert M., Hauser, Taissa S., Grankvist, Alexander, Hultman, Christina M., and Lichtenstein, Paul

Published
2012
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22. Associations of autozygosity with a broad range of human phenotypes

Author

Clark, David W, Okada, Yukinori, Moore, Kristjan H S, Mason, Dan, Pirastu, Nicola, Gandin, Ilaria, Mattsson, Hannele, Barnes, Catriona L K, Lin, Kuang, Zhao, Jing Hua, Deelen, Patrick, Rohde, Rebecca, Schurmann, Claudia, Guo, Xiuqing, Giulianini, Franco, Zhang, Weihua, Medina-Gomez, Carolina, Karlsson, Robert, Bao, Yanchun, Bartz, Traci M, Baumbach, Clemens, Biino, Ginevra, Bixley, Matthew J, Brumat, Marco, Chai, Jin-Fang, Corre, Tanguy, Cousminer, Diana L, Dekker, Annelot M, Eccles, David A, van Eijk, Kristel R, Fuchsberger, Christian, Gao, He, Germain, Marine, Gordon, Scott D, de Haan, Hugoline G, Harris, Sarah E, Hofer, Edith, Huerta-Chagoya, Alicia, Igartua, Catherine, Jansen, Iris E, Jia, Yucheng, Kacprowski, Tim, Karlsson, Torgny, Kleber, Marcus E, Li, Shengchao Alfred, Li-Gao, Ruifang, Mahajan, Anubha, Matsuda, Koichi, Meidtner, Karina, Meng, Weihua, Montasser, May E, van der Most, Peter J, Munz, Matthias, Nutile, Teresa, Palviainen, Teemu, Prasad, Gauri, Prasad, Rashmi B, Priyanka, Tallapragada Divya Sri, Rizzi, Federica, Salvi, Erika, Sapkota, Bishwa R, Shriner, Daniel, Skotte, Line, Smart, Melissa C, Smith, Albert Vernon, van der Spek, Ashley, Spracklen, Cassandra N, Strawbridge, Rona J, Tajuddin, Salman M, Trompet, Stella, Turman, Constance, Verweij, Niek, Viberti, Clara, Wang, Lihua, Warren, Helen R, Wootton, Robyn E, Yanek, Lisa R, Yao, Jie, Yousri, Noha A, Zhao, Wei, Adeyemo, Adebowale A, Afaq, Saima, Aguilar-Salinas, Carlos Alberto, Akiyama, Masato, Albert, Matthew L, Allison, Matthew A, Alver, Maris, Aung, Tin, Azizi, Fereidoun, Bentley, Amy R, Boeing, Heiner, Boerwinkle, Eric, Borja, Judith B, de Borst, Gert J, Bottinger, Erwin P, Broer, Linda, Campbell, Harry, Chanock, Stephen, Chee, Miao-Li, Chen, Guanjie, Chen, Yii-Der I, Chen, Zhengming, Chiu, Yen-Feng, Cocca, Massimiliano, Collins, Francis S, Concas, Maria Pina, Corley, Janie, Cugliari, Giovanni, van Dam, Rob M, Damulina, Anna, Daneshpour, Maryam S, Day, Felix R, Delgado, Graciela E, Dhana, Klodian, Doney, Alexander S F, Dörr, Marcus, Doumatey, Ayo P, Dzimiri, Nduna, Ebenesersdóttir, S Sunna, Elliott, Joshua, Elliott, Paul, Ewert, Ralf, Felix, Janine F, Fischer, Krista, Freedman, Barry I, Girotto, Giorgia, Goel, Anuj, Gögele, Martin, Goodarzi, Mark O, Graff, Mariaelisa, Granot-Hershkovitz, Einat, Grodstein, Francine, Guarrera, Simonetta, Gudbjartsson, Daniel F, Guity, Kamran, Gunnarsson, Bjarni, Guo, Yu, Hagenaars, Saskia P, Haiman, Christopher A, Halevy, Avner, Harris, Tamara B, Hedayati, Mehdi, van Heel, David A, Hirata, Makoto, Höfer, Imo, Hsiung, Chao Agnes, Huang, Jinyan, Hung, Yi-Jen, Ikram, M Arfan, Jagadeesan, Anuradha, Jousilahti, Pekka, Kamatani, Yoichiro, Kanai, Masahiro, Kerrison, Nicola D, Kessler, Thorsten, Khaw, Kay-Tee, Khor, Chiea Chuen, de Kleijn, Dominique P V, Koh, Woon-Puay, Kolcic, Ivana, Kraft, Peter, Krämer, Bernhard K, Kutalik, Zoltán, Kuusisto, Johanna, Langenberg, Claudia, Launer, Lenore J, Lawlor, Deborah A, Lee, I-Te, Lee, Wen-Jane, Lerch, Markus M, Li, Liming, Liu, Jianjun, Loh, Marie, London, Stephanie J, Loomis, Stephanie, Lu, Yingchang, Luan, Jian’an, Mägi, Reedik, Manichaikul, Ani W, Manunta, Paolo, Másson, Gísli, Matoba, Nana, Mei, Xue W, Meisinger, Christa, Meitinger, Thomas, Mezzavilla, Massimo, Milani, Lili, Millwood, Iona Y, Momozawa, Yukihide, Moore, Amy, Morange, Pierre-Emmanuel, Moreno-Macías, Hortensia, Mori, Trevor A, Morrison, Alanna C, Muka, Taulant, Murakami, Yoshinori, Murray, Alison D, de Mutsert, Renée, Mychaleckyj, Josyf C, Nalls, Mike A, Nauck, Matthias, Neville, Matt J, Nolte, Ilja M, Ong, Ken K, Orozco, Lorena, Padmanabhan, Sandosh, Pálsson, Gunnar, Pankow, James S, Pattaro, Cristian, Pattie, Alison, Polasek, Ozren, Poulter, Neil, Pramstaller, Peter P, Quintana-Murci, Lluis, Räikkönen, Katri, Ralhan, Sarju, Rao, Dabeeru C, van Rheenen, Wouter, Rich, Stephen S, Ridker, Paul M, Rietveld, Cornelius A, Robino, Antonietta, van Rooij, Frank J A, Ruggiero, Daniela, Saba, Yasaman, Sabanayagam, Charumathi, Sabater-Lleal, Maria, Sala, Cinzia Felicita, Salomaa, Veikko, Sandow, Kevin, Schmidt, Helena, Scott, Laura J, Scott, William R, Sedaghati-Khayat, Bahareh, Sennblad, Bengt, van Setten, Jessica, Sever, Peter J, Sheu, Wayne H-H, Shi, Yuan, Shrestha, Smeeta, Shukla, Sharvari Rahul, Sigurdsson, Jon K, Sikka, Timo Tonis, Singh, Jai Rup, Smith, Blair H, Stančáková, Alena, Stanton, Alice, Starr, John M, Stefansdottir, Lilja, Straker, Leon, Sulem, Patrick, Sveinbjornsson, Gardar, Swertz, Morris A, Taylor, Adele M, Taylor, Kent D, Terzikhan, Natalie, Tham, Yih-Chung, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Tillander, Annika, Tracy, Russell P, Tusié-Luna, Teresa, Tzoulaki, Ioanna, Vaccargiu, Simona, Vangipurapu, Jagadish, Veldink, Jan H, Vitart, Veronique, Völker, Uwe, Vuoksimaa, Eero, Wakil, Salma M, Waldenberger, Melanie, Wander, Gurpreet S, Wang, Ya Xing, Wareham, Nicholas J, Wild, Sarah, Yajnik, Chittaranjan S, Yuan, Jian-Min, Zeng, Lingyao, Zhang, Liang, Zhou, Jie, Amin, Najaf, Asselbergs, Folkert W, Bakker, Stephan J L, Becker, Diane M, Lehne, Benjamin, Bennett, David A, van den Berg, Leonard H, Berndt, Sonja I, Bharadwaj, Dwaipayan, Bielak, Lawrence F, Bochud, Murielle, Boehnke, Mike, Bouchard, Claude, Bradfield, Jonathan P, Brody, Jennifer A, Campbell, Archie, Carmi, Shai, Caulfield, Mark J, Cesarini, David, Chambers, John C, Chandak, Giriraj Ratan, Cheng, Ching-Yu, Ciullo, Marina, Cornelis, Marilyn, Cusi, Daniele, Smith, George Davey, Deary, Ian J, Dorajoo, Rajkumar, van Duijn, Cornelia M, Ellinghaus, David, Erdmann, Jeanette, Eriksson, Johan G, Evangelou, Evangelos, Evans, Michele K, Faul, Jessica D, Feenstra, Bjarke, Feitosa, Mary, Foisy, Sylvain, Franke, Andre, Friedlander, Yechiel, Gasparini, Paolo, Gieger, Christian, Gonzalez, Clicerio, Goyette, Philippe, Grant, Struan F A, Griffiths, Lyn R, Groop, Leif, Gudnason, Vilmundur, Gyllensten, Ulf, Hakonarson, Hakon, Hamsten, Anders, van der Harst, Pim, Heng, Chew-Kiat, Hicks, Andrew A, Hochner, Hagit, Huikuri, Heikki, Hunt, Steven C, Jaddoe, Vincent W V, De Jager, Philip L, Johannesson, Magnus, Johansson, Åsa, Jonas, Jost B, Jukema, J Wouter, Junttila, Juhani, Kaprio, Jaakko, Kardia, Sharon L. R., Karpe, Fredrik, Kumari, Meena, Laakso, Markku, van der Laan, Sander W, Lahti, Jari, Laudes, Matthias, Lea, Rodney A, Lieb, Wolfgang, Lumley, Thomas, Martin, Nicholas G, März, Winfried, Matullo, Giuseppe, McCarthy, Mark I, Medland, Sarah E, Merriman, Tony R, Metspalu, Andres, Meyer, Brian F, Mohlke, Karen L, Montgomery, Grant W, Mook-Kanamori, Dennis, Munroe, Patricia B, North, Kari E, Nyholt, Dale R, O’connell, Jeffery R, Ober, Carole, Oldehinkel, Albertine J, Palmas, Walter, Palmer, Colin, Pasterkamp, Gerard G, Patin, Etienne, Pennell, Craig E, Perusse, Louis, Peyser, Patricia A, Pirastu, Mario, Polderman, Tinca J. C., Porteous, David J, Posthuma, Danielle, Psaty, Bruce M, Rioux, John D, Rivadeneira, Fernando, Rotimi, Charles, Rotter, Jerome I, Rudan, Igor, Den Ruijter, Hester M, Sanghera, Dharambir K, Sattar, Naveed, Schmidt, Reinhold, Schulze, Matthias B, Schunkert, Heribert, Scott, Robert A, Shuldiner, Alan R, Sim, Xueling, Small, Neil, Smith, Jennifer A, Sotoodehnia, Nona, Tai, E-Shyong, Teumer, Alexander, Timpson, Nicholas J, Toniolo, Daniela, Tregouet, David-Alexandre, Tuomi, Tiinamaija, Vollenweider, Peter, Wang, Carol A, Weir, David R, Whitfield, John B, Wijmenga, Cisca, Wong, Tien-Yin, Wright, John, Yang, Jingyun, Yu, Lei, Zemel, Babette S, Zonderman, Alan B, Perola, Markus, Magnusson, Patrik K. E., Uitterlinden, André G, Kooner, Jaspal S, Chasman, Daniel I, Loos, Ruth J. F., Franceschini, Nora, Franke, Lude, Haley, Chris S, Hayward, Caroline, Walters, Robin G, Perry, John R. B., Esko, Tōnu, Helgason, Agnar, Stefansson, Kari, Joshi, Peter K, Kubo, Michiaki, and Wilson, James F

Published
2019
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23. Financial Windfalls, Portfolio Allocations, and Risk Preferences

Author

Lindqvist, Erik, Briggs, Joseph, Cesarini, David, Östling, Robert, Chanwook Lee, Sean, Lindqvist, Erik, Briggs, Joseph, Cesarini, David, Östling, Robert, and Chanwook Lee, Sean

Abstract

We investigate the impact of financial windfalls on household portfolio choices and risk exposure. Exploiting the randomized assignment of lottery prizes in three Swedish lotteries, we find a windfall gain of $100K leads to a 5-percentage-point de- crease in the risky share of household portfolios. We show theoretically that negative wealth effects are consistent with both constant and decreasing relative risk aversion and analyze how our empirical estimates help distinguish between competing models of portfolio choice. We further show our results are quantitatively aligned with the predictions of a calibrated dynamic portfolio choice model with nontradable human capital and consumption habits.

Published
2023

24. Does Wealth Inhibit Criminal Behavior? Evidence From Swedish Lottery Winners and Their Children

Author

Lindqvist, Erik, Cesarini, David, Östling, Robert, Schroeder, Christofer, Lindqvist, Erik, Cesarini, David, Östling, Robert, and Schroeder, Christofer

Abstract

There is a well-established negative gradient between economic status and crime, but its underlying causal mechanisms are not well understood. We use data on four Swedish lotteries matched to data on criminal convictions to gauge the causal effect of financial windfalls on player`s own crime and their children`s delinquency. We estimate a positive but statistically insignificant effect of lottery wealth on players`own conviction risk. Our estimates allows us to rule out effects one fifth as large as the cross-sectional gradient between income and crime. We also estimate a less precise null effect of parental lottery wealth on child delinquency.

Published
2023

25. Fortunate Families? The Effects of Wealth on Marriage and Fertility.

Author

Lindqvist, Erik, Cesarini, David, Östling, Robert, Terskaya, Anastasia, Lindqvist, Erik, Cesarini, David, Östling, Robert, and Terskaya, Anastasia

Abstract

We estimate the effects of large, positive wealth shocks on marriage and fertility in a sample of Swedish lottery players. For male winners, wealth increases marriage formation and reduces divorce risk, suggesting wealth increases men’s attractiveness as prospective and current partners. Wealth also increases male fertility. The only discernible effect on female winners is that wealth increases their short-run (but not long-run) divorce risk. Our results for divorce are consistent with a model where the wealthier spouse retains most of his/her wealth in divorce. In support of this assumption, we show divorce settlements in Sweden often favor the richer spouse. JEL Codes: D1, J12, J13., We thank Eva Forslund and Ludovica Ciasullo for excellent research assistance and participants at multiple conferences and seminars for helpful feedback on earlier versions of this manuscript. The study was supported by the Swedish Research Council (421-2011-2139 and 2022-02686), the Handelsbanken Re- search Foundation (P2011:0032:1), Riksbankens Jubileumsfond (P15-0514:1) and the Ragnar Söderberg Foundation (E4/17). †Department of Economics, New York University, 19 W. 4th Street, 6FL, New York 10012, NBER, and Research Institute of Industrial Economics (IFN). E-mail: david.cesarini@nyu.edu. ‡Swedish Institute for Social Research (SOFI), Stockholm University, SE-106 91 Stockholm Sweden, and CEPR. E-mail: erik.lindqvist@sofi.su.se. §Department of Economics, Stockholm School of Economics, P.O. Box 6501, SE-113 83 Stockholm, Sweden. E-mail: robert.ostling@hhs.se. ¶Corresponding author. Department of Economics and IEB, Universidad de Barcelona, Carrer de John Maynard Keynes, 1, 11, 08034 Barcelona, Spain (e-mail: anastasiaterskaya@gmail.com).

Published
2023

26. Genome-wide association meta-analysis of 78,308 individuals identifies new loci and genes influencing human intelligence

Author

Sniekers, Suzanne, Stringer, Sven, Watanabe, Kyoko, Jansen, Philip R, Coleman, Jonathan R I, Krapohl, Eva, Taskesen, Erdogan, Hammerschlag, Anke R, Okbay, Aysu, Zabaneh, Delilah, Amin, Najaf, Breen, Gerome, Cesarini, David, Chabris, Christopher F, Iacono, William G, Ikram, M Arfan, Johannesson, Magnus, Koellinger, Philipp, Lee, James J, Magnusson, Patrik K E, McGue, Matt, Miller, Mike B, Ollier, William E R, Payton, Antony, Pendleton, Neil, Plomin, Robert, Rietveld, Cornelius A, Tiemeier, Henning, van Duijn, Cornelia M, and Posthuma, Danielle

Published
2017
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29. Smoking is associated with mosaic loss of chromosome Y

Author

Dumanski, Jan P., Rasi, Chiara, Lönn, Mikael, Davies, Hanna, Ingelsson, Martin, Giedraitis, Vilmantas, Lannfelt, Lars, Magnusson, Patrik K. E., Lindgren, Cecilia M., Morris, Andrew P., Cesarini, David, Johannesson, Magnus, Janson, Eva Tiensuu, Lind, Lars, Pedersen, Nancy L., Ingelsson, Erik, and Forsberg, Lars A.

Published
2015

30. Replicability and Robustness of Genome-Wide-Association Studies for Behavioral Traits

Author

the Social Science Genetics Association Consortium, Rietveld, Cornelius A., Conley, Dalton, Eriksson, Nicholas, Esko, Tõnu, Medland, Sarah E., Vinkhuyzen, Anna A. E., Yang, Jian, Boardman, Jason D., Chabris, Christopher F., Dawes, Christopher T., Domingue, Benjamin W., Hinds, David A., Johannesson, Magnus, Kiefer, Amy K., Laibson, David, Magnusson, Patrik K. E., Mountain, Joanna L., Oskarsson, Sven, Rostapshova, Olga, Teumer, Alexander, Tung, Joyce Y., Visscher, Peter M., Benjamin, Daniel J., Cesarini, David, and Koellinger, Philipp D.

Published
2014

32. Common genetic variants associated with cognitive performance identified using the proxy-phenotype method

Author

Rietveld, Cornelius A., Esko, Tõnu, Davies, Gail, Pers, Tune H., Turley, Patrick, Benyamin, Beben, Chabris, Christopher F., Emilsson, Valur, Johnson, Andrew D., Lee, James J., de Leeuw, Christiaan, Marioni, Riccardo E., Medland, Sarah E., Miller, Michael B., Rostapshova, Olga, van der Lee, Sven J., Vinkhuyzen, Anna A. E., Amin, Najaf, Conley, Dalton, Derringer, Jaime, van Duijn, Cornelia M., Fehrmann, Rudolf, Franke, Lude, Glaeser, Edward L., Hansell, Narelle K., Hayward, Caroline, Iacono, William G., Ibrahim-Verbaas, Carla, Jaddoe, Vincent, Karjalainen, Juha, Laibson, David, Lichtenstein, Paul, Liewald, David C., Magnusson, Patrik K. E., Martin, Nicholas G., McGue, Matt, McMahon, George, Pedersen, Nancy L., Pinker, Steven, Porteous, David J., Posthuma, Danielle, Rivadeneira, Fernando, Smith, Blair H., Starr, John M., Tiemeier, Henning, Timpson, Nicholas J., Trzaskowski, Maciej, Uitterlinden, André G., Verhulst, Frank C., Ward, Mary E., Wright, Margaret J., Smith, George Davey, Deary, Ian J., Johannesson, Magnus, Plomin, Robert, Visscher, Peter M., Benjamin, Daniel J., Cesarini, David, and Koellinger, Philipp D.

Published
2014

34. Genome-wide association study identifies 74 loci associated with educational attainment

Author

Okbay, Aysu, Beauchamp, Jonathan P., Fontana, Mark Alan, Lee, James J., Pers, Tune H., Rietveld, Cornelius A., Turley, Patrick, Chen, Guo-Bo, Emilsson, Valur, Meddens, S. Fleur W., Oskarsson, Sven, Pickrell, Joseph K., Thom, Kevin, Timshel, Pascal, de Vlaming, Ronald, Abdellaoui, Abdel, Ahluwalia, Tarunveer S., Bacelis, Jonas, Baumbach, Clemens, Bjornsdottir, Gyda, Brandsma, Johannes H., Pina Concas, Maria, Derringer, Jaime, Furlotte, Nicholas A., Galesloot, Tessel E., Girotto, Giorgia, Gupta, Richa, Hall, Leanne M., Harris, Sarah E., Hofer, Edith, Horikoshi, Momoko, Huffman, Jennifer E., Kaasik, Kadri, Kalafati, Ioanna P., Karlsson, Robert, Kong, Augustine, Lahti, Jari, Lee, Sven J. van der, deLeeuw, Christiaan, Lind, Penelope A., Lindgren, Karl-Oskar, Liu, Tian, Mangino, Massimo, Marten, Jonathan, Mihailov, Evelin, Miller, Michael B., van der Most, Peter J., Oldmeadow, Christopher, Payton, Antony, Pervjakova, Natalia, Peyrot, Wouter J., Qian, Yong, Raitakari, Olli, Rueedi, Rico, Salvi, Erika, Schmidt, Börge, Schraut, Katharina E., Shi, Jianxin, Smith, Albert V., Poot, Raymond A., St Pourcain, Beate, Teumer, Alexander, Thorleifsson, Gudmar, Verweij, Niek, Vuckovic, Dragana, Wellmann, Juergen, Westra, Harm-Jan, Yang, Jingyun, Zhao, Wei, Zhu, Zhihong, Alizadeh, Behrooz Z., Amin, Najaf, Bakshi, Andrew, Baumeister, Sebastian E., Biino, Ginevra, Bønnelykke, Klaus, Boyle, Patricia A., Campbell, Harry, Cappuccio, Francesco P., Davies, Gail, De Neve, Jan-Emmanuel, Deloukas, Panos, Demuth, Ilja, Ding, Jun, Eibich, Peter, Eisele, Lewin, Eklund, Niina, Evans, David M., Faul, Jessica D., Feitosa, Mary F., Forstner, Andreas J., Gandin, Ilaria, Gunnarsson, Bjarni, Halldórsson, Bjarni V., Harris, Tamara B., Heath, Andrew C., Hocking, Lynne J., Holliday, Elizabeth G., Homuth, Georg, Horan, Michael A., Hottenga, Jouke-Jan, de Jager, Philip L., Joshi, Peter K., Jugessur, Astanand, Kaakinen, Marika A., Kähönen, Mika, Kanoni, Stavroula, Keltigangas-Järvinen, Liisa, Kiemeney, Lambertus A. L. M., Kolcic, Ivana, Koskinen, Seppo, Kraja, Aldi T., Kroh, Martin, Kutalik, Zoltan, Latvala, Antti, Launer, Lenore J., Lebreton, Maël P., Levinson, Douglas F., Lichtenstein, Paul, Lichtner, Peter, Liewald, David C. M., Cohort Study, LifeLines, Loukola, Anu, Madden, Pamela A., Mägi, Reedik, Mäki-Opas, Tomi, Marioni, Riccardo E., Marques-Vidal, Pedro, Meddens, Gerardus A., McMahon, George, Meisinger, Christa, Meitinger, Thomas, Milaneschi, Yusplitri, Milani, Lili, Montgomery, Grant W., Myhre, Ronny, Nelson, Christopher P., Nyholt, Dale R., Ollier, William E. R., Palotie, Aarno, Paternoster, Lavinia, Pedersen, Nancy L., Petrovic, Katja E., Porteous, David J., Räikkönen, Katri, Ring, Susan M., Robino, Antonietta, Rostapshova, Olga, Rudan, Igor, Rustichini, Aldo, Salomaa, Veikko, Sanders, Alan R., Sarin, Antti-Pekka, Schmidt, Helena, Scott, Rodney J., Smith, Blair H., Smith, Jennifer A., Staessen, Jan A., Steinhagen-Thiessen, Elisabeth, Strauch, Konstantin, Terracciano, Antonio, Tobin, Martin D., Ulivi, Sheila, Vaccargiu, Simona, Quaye, Lydia, van Rooij, Frank J. A., Venturini, Cristina, Vinkhuyzen, Anna A. E., Völker, Uwe, Völzke, Henry, Vonk, Judith M., Vozzi, Diego, Waage, Johannes, Ware, Erin B., Willemsen, Gonneke, Attia, John R., Bennett, David A., Berger, Klaus, Bertram, Lars, Bisgaard, Hans, Boomsma, Dorret I., Borecki, Ingrid B., Bültmann, Ute, Chabris, Christopher F., Cucca, Francesco, Cusi, Daniele, Deary, Ian J., Dedoussis, George V., van Duijn, Cornelia M., Eriksson, Johan G., Franke, Barbara, Franke, Lude, Gasparini, Paolo, Gejman, Pablo V., Gieger, Christian, Grabe, Hans-Jörgen, Gratten, Jacob, Groenen, Patrick J. F., Gudnason, Vilmundur, van der Harst, Pim, Hayward, Caroline, Hinds, David A., Hoffmann, Wolfgang, Hyppönen, Elina, Iacono, William G., Jacobsson, Bo, Järvelin, Marjo-Riitta, Jöckel, Karl-Heinz, Kaprio, Jaakko, Kardia, Sharon L. R., Lehtimäki, Terho, Lehrer, Steven F., Magnusson, Patrik K. E., Martin, Nicholas G., McGue, Matt, Metspalu, Andres, Pendleton, Neil, Penninx, Brenda W. J. H., Perola, Markus, Pirastu, Nicola, Pirastu, Mario, Polasek, Ozren, Posthuma, Danielle, Power, Christine, Province, Michael A., Samani, Nilesh J., Schlessinger, David, Schmidt, Reinhold, Sørensen, Thorkild I. A., Spector, Tim D., Stefansson, Kari, Thorsteinsdottir, Unnur, Thurik, A. Roy, Timpson, Nicholas J., Tiemeier, Henning, Tung, Joyce Y., Uitterlinden, André G., Vitart, Veronique, Vollenweider, Peter, Weir, David R., Wilson, James F., Wright, Alan F., Conley, Dalton C., Krueger, Robert F., Davey Smith, George, Hofman, Albert, Laibson, David I., Medland, Sarah E., Meyer, Michelle N., Yang, Jian, Johannesson, Magnus, Visscher, Peter M., Esko, Tõnu, Koellinger, Philipp D., Cesarini, David, and Benjamin, Daniel J.

Published
2016
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38. GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment

Author

The LifeLines Cohort Study, Rietveld, Cornelius A., Medland, Sarah E., Derringer, Jaime, Yang, Jian, Esko, Tõnu, Martin, Nicolas W., Westra, Harm-Jan, Shakhbazov, Konstantin, Abdellaoui, Abdel, Agrawal, Arpana, Albrecht, Eva, Alizadeh, Behrooz Z., Amin, Najaf, Barnard, John, Baumeister, Sebastian E., Benke, Kelly S., Bielak, Lawrence F., Boatman, Jeffrey A., Boyle, Patricia A., Davies, Gail, de Leeuw, Christiaan, Eklund, Niina, Evans, Daniel S., Ferhmann, Rudolf, Fischer, Krista, Gieger, Christian, Gjessing, Håkon K., Hägg, Sara, Harris, Jennifer R., Hayward, Caroline, Holzapfel, Christina, Ibrahim-Verbaas, Carla A., Ingelsson, Erik, Jacobsson, Bo, Joshi, Peter K., Jugessur, Astanand, Kaakinen, Marika, Kanoni, Stavroula, Karjalainen, Juha, Kolcic, Ivana, Kristiansson, Kati, Kutalik, Zoltán, Lahti, Jari, Lee, Sang H., Lin, Peng, Lind, Penelope A., Liu, Yongmei, Lohman, Kurt, Loitfelder, Marisa, McMahon, George, Vidal, Pedro Marques, Meirelles, Osorio, Milani, Lili, Myhre, Ronny, Nuotio, Marja-Liisa, Oldmeadow, Christopher J., Petrovic, Katja E., Peyrot, Wouter J., Polašek, Ozren, Quaye, Lydia, Reinmaa, Eva, Rice, John P., Rizzi, Thais S., Schmidt, Helena, Schmidt, Reinhold, Smith, Albert V., Smith, Jennifer A., Tanaka, Toshiko, Terracciano, Antonio, van der Loos, Matthijs J. H. M., Vitart, Veronique, Völzke, Henry, Wellmann, Jürgen, Yu, Lei, Zhao, Wei, Allik, Jüri, Attia, John R., Bandinelli, Stefania, Bastardot, François, Beauchamp, Jonathan, Bennett, David A., Berger, Klaus, Bierut, Laura J., Boomsma, Dorret I., Bültmann, Ute, Campbell, Harry, Chabris, Christopher F., Cherkas, Lynn, Chung, Mina K., Cueca, Francesco, de Andrade, Mariza, De Jager, Philip L., De Neve, Jan-Emmanuel, Deary, Ian J., Dedoussis, George V., Deloukas, Panos, Dimitriou, Maria, Eiríksdóttir, Guðný, Elderson, Martin F., Eriksson, Johan G., Evans, David M., Faul, Jessica D., Ferrucci, Luigi, Garcia, Melissa E., Grönberg, Henrik, Guðnason, Vilmundur, Hall, Per, Harris, Juliette M., Harris, Tamara B., Hastie, Nicholas D., Heath, Andrew C., Hernandez, Dena G., Hoffmann, Wolfgang, Hofman, Adriaan, Holle, Rolf, Holliday, Elizabeth G., Hottenga, Jouke-Jan, Iacono, William G., Illig, Thomas, Järvelin, Marjo-Riitta, Kähönen, Mika, Kaprio, Jaakko, Kirkpatrick, Robert M., Kowgier, Matthew, Latvala, Antti, Launer, Lenore J., Lawior, Debbie A., Lehtimäki, Terho, Li, Jingmei, Lichtenstein, Paul, Lichtner, Peter, Liewald, David C., Madden, Pamela A., Magnusson, Patrik K. E., Mäkinen, Tomi E., Masala, Marco, McGue, Matt, Metspalu, Andres, Mielck, Andreas, Miller, Michael B., Montgomery, Grant W., Mukherjee, Sutapa, Nyholt, Dale R., Oostra, Ben A., Palmer, Lyle J., Palotie, Aarno, Penninx, Brenda W. J. H., Perola, Markus, Peyser, Patricia A., Preisig, Martin, Räikkönen, Katri, Raitakari, Olli T., Realo, Anu, Ring, Susan M., Ripatti, Samuli, Rivadeneira, Fernando, Rudan, Igor, Rustichini, Aldo, Salomaa, Veikko, Sarin, Antti-Pekka, Schlessinger, David, Scott, Rodney J., Snieder, Harold, St Pourcain, Beate, Starr, John M., Sul, Jae Hoon, Surakka, Ida, Svento, Rauli, Teumer, Alexander, Tiemeier, Henning, van Rooij, Frank J. A., Van Wagoner, David R., Vartiainen, Erkki, Viikari, Jorma, Vollenweider, Peter, Vonk, Judith M., Waeber, Gérard, Weir, David R., Wichmann, H.-Erich, Widen, Elisabeth, Willemsen, Gonneke, Wilson, James F., Wright, Alan F., Conley, Dalton, Davey-Smith, George, Franke, Lude, Groenen, Patrick J. F., Hofman, Albert, Johannesson, Magnus, Kardia, Sharon L. R., Krueger, Robert F., Laibson, David, Martin, Nicholas G., Meyer, Michelle N., Posthuma, Danielle, Thurik, A. Roy, Timpson, Nicholas J., Uitterlinden, André G., van Duijn, Cornelia M., Visscher, Peter M., Benjamin, Daniel J., Cesarini, David, and Koellinger, Philipp D.

Published
2013
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39. Molecular genetics and subjective well-being

Author

Rietveld, Cornelius A., Cesarini, David, Benjamin, Daniel J., Koellinger, Philipp D., De Neve, Jan-Emmanuel, Tiemeier, Henning, Johannesson, Magnus, Magnusson, Patrik K. E., Pedersen, Nancy L., Krueger, Robert F., and Bartels, Meike

Published
2013

41. Political Participation of Swedish Lottery Players

Author

Östling, Robert, Cesarini, David, Lindqvist, Erik, Oskarsson, Sven, Lindgren, Karl-Oskar, and Brännlund, Anton

Subjects
Economics, Political Science, FOS: Political science, Social and Behavioral Sciences
Abstract

This project will examine how substantial changes in wealth impact behaviors in two domains of political participation – turnout and political candidacy. The study draws on a sample of Swedish lottery players used in several recent quasi-experimental studies.

Published
2022
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43. The genetic architecture of economic and political preferences

Author

Benjamin, Daniel J., Cesarini, David, van der Loos, Matthijs J. H. M., Dawes, Christopher T., Koellinger, Philipp D., Magnusson, Patrik K. E., Chabris, Christopher F., Conley, Dalton, Laibson, David, Johannesson, Magnus, and Visscher, Peter M.

Published
2012

45. Author Correction: Multi-trait analysis of genome-wide association summary statistics using MTAG

Author

Turley, Patrick, Walters, Raymond K., Maghzian, Omeed, Okbay, Aysu, Lee, James J., Fontana, Mark Alan, Nguyen-Viet, Tuan Anh, Wedow, Robbee, Zacher, Meghan, Furlotte, Nicholas A., 23andMe Research Team, Social Science Genetic Association Consortium, Magnusson, Patrik, Oskarsson, Sven, Johannesson, Magnus, Visscher, Peter M., Laibson, David, Cesarini, David, Neale, Benjamin M., and Benjamin, Daniel J.

Published
2019
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46. Publisher Correction: Multi-trait analysis of genome-wide association summary statistics using MTAG

Author

Turley, Patrick, Walters, Raymond K., Maghzian, Omeed, Okbay, Aysu, Lee, James J., Fontana, Mark Alan, Nguyen-Viet, Tuan Anh, Wedow, Robbee, Zacher, Meghan, Furlotte, Nicholas A., 23andMe Research Team, Social Science Genetic Association Consortium, Magnusson, Patrik, Oskarsson, Sven, Johannesson, Magnus, Visscher, Peter M., Laibson, David, Cesarini, David, Neale, Benjamin M., and Benjamin, Daniel J.

Published
2019
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47. Molecular Genetics and Economics

Author

Beauchamp, Jonathan P., Cesarini, David, Johannesson, Magnus, van der Loos, Matthijs J. H. M., Koellinger, Philipp D., Groenen, Patrick J. F., Fowler, James H., Rosenquist, J. Niels, Thurik, A. Roy, and Christakis, Nicholas A.

Published
2011

48. Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour

Author

Mills, Melinda C., Tropf, Felix C., Brazel, David M., van Zuydam, Natalie, Vaez, Ahmad, Agbessi, Mawussé, Ahsan, Habibul, Alves, Isabel, Andiappan, Anand Kumar, Arindrarto, Wibowo, Awadalla, Philip, Battle, Alexis, Beutner, Frank, Jan Bonder, Marc, Boomsma, Dorret I., Christiansen, Mark W., Claringbould, Annique, Deelen, Patrick, Esko, Tõnu, Favé, Marie-Julie, Franke, Lude, Frayling, Timothy, Gharib, Sina A., Gibson, Greg, Heijmans, Bastiaan T., Hemani, Gibran, Jansen, Rick, Kähönen, Mika, Kalnapenkis, Anette, Kasela, Silva, Kettunen, Johannes, Kim, Yungil, Kirsten, Holger, Kovacs, Peter, Krohn, Knut, Kronberg, Jaanika, Kukushkina, Viktorija, Kutalik, Zoltan, Lee, Bernett, Lehtimäki, Terho, Loeffler, Markus, Marigorta, Urko M., Mei, Hailang, Milani, Lili, Montgomery, Grant W., Müller-Nurasyid, Martina, Nauck, Matthias, Nivard, Michel G., Penninx, Brenda W. J. H., Perola, Markus, Pervjakova, Natalia, Pierce, Brandon L., Powell, Joseph, Prokisch, Holger, Psaty, Bruce M., Raitakari, Olli T., Ripatti, Samuli, Rotzschke, Olaf, Rüeger, Sina, Saha, Ashis, Scholz, Markus, Schramm, Katharina, Seppälä, Ilkka, Slagboom, Eline P., Stehouwer, Coen D. A., Stumvoll, Michael, Sullivan, Patrick, ‘t Hoen, Peter A. C., Teumer, Alexander, Thiery, Joachim, Tong, Lin, Tönjes, Anke, van Dongen, Jenny, van Iterson, Maarten, van Meurs, Joyce, Veldink, Jan H., Verlouw, Joost, Visscher, Peter M., Völker, Uwe, Võsa, Urmo, Westra, Harm-Jan, Wijmenga, Cisca, Yaghootkar, Hanieh, Yang, Jian, Zeng, Biao, Zhang, Futao, Isaacs, Aaron, Pool, René, Jan Hottenga, Jouke, van Greevenbroek, Marleen M. J., van der Kallen, Carla J. H., Schalkwijk, Casper G., Zhernakova, Sasha, Tigchelaar, Ettje F., Beekman, Marian, Deelen, Joris, van Heemst, Diana, van den Berg, Leonard H., van Duijn, Cornelia M., Hofman, Bert A., Uitterlinden, André G., Jhamai, P. Mila, Verbiest, Michael, Suchiman, H. Eka D., Verkerk, Marijn, van der Breggen, Ruud, van Rooij, Jeroen, Lakenberg, Nico, Mei, Hailiang, van Galen, Michiel, Bot, Jan, Zhernakova, Dasha V., van ’t Hof, Peter, Nooren, Irene, Moed, Matthijs, Vermaat, Martijn, Luijk, René, van Dijk, Freerk, Kielbasa, Szymon M., Swertz, Morris A., van Zwet, Erik. W., Akimova, Evelina T., Bergmann, Sven, Boardman, Jason D., Brumat, Marco, Buring, Julie E., Cesarini, David, Chasman, Daniel I., Chavarro, Jorge E., Cocca, Massimiliano, Concas, Maria Pina, Davey-Smith, George, Davies, Gail, Deary, Ian J., Franco, Oscar, Gaskins, Audrey J., de Geus, Eco J. C., Gieger, Christian, Girotto, Giorgia, Grabe, Hans Jörgen, Gunderson, Erica P., Harris, Kathleen Mullan, Hartwig, Fernando P., He, Chunyan, Hill, W. David, Homuth, Georg, Horta, Bernando Lessa, Huang, Hongyang, Hyppӧnen, Elina, Ikram, M. Arfan, Johannesson, Magnus, Kamali, Zoha, Kavousi, Maryam, Kraft, Peter, Kühnel, Brigitte, Langenberg, Claudia, Lind, Penelope A., Luan, Jian’an, Mägi, Reedik, Magnusson, Patrik K. E., Mahajan, Anubha, Martin, Nicholas G., Mbarek, Hamdi, McCarthy, Mark I., McMahon, George, McQueen, Matthew B., Medland, Sarah E., Meitinger, Thomas, Metspalu, Andres, Mihailov, Evelin, Missmer, Stacey A., Møllegaard, Stine, Mook-Kanamori, Dennis O., Morgan, Anna, van der Most, Peter J., de Mutsert, Renée, Nolte, Ilja M., Noordam, Raymond, Peters, Annette, Power, Chris, Redmond, Paul, Rich-Edwards, Janet W., Ridker, Paul M., Rietveld, Cornelius A., Ring, Susan M., Rose, Lynda M., Rueedi, Rico, Stefánsson, Kári, Stöckl, Doris, Strauch, Konstantin, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Thurik, A. Roy, Timpson, Nicholas J., Turman, Constance, Waldenberger, Melanie, Wareham, Nicholas J., Willemsen, Gonneke, Zhao, Jing Hau, Pers, Tune H., Snieder, Harold, Perry, John R. B., Ong, Ken K., den Hoed, Marcel, Barban, Nicola, Day, Felix R., Mills, M. C., Tropf, F. C., Brazel, D. M., van Zuydam, N., Vaez, A., Agbessi, M., Ahsan, H., Alves, I., Andiappan, A. K., Arindrarto, W., Awadalla, P., Battle, A., Beutner, F., Jan Bonder, M., Boomsma, D. I., Christiansen, M. W., Claringbould, A., Deelen, P., Esko, T., Fave, M. -J., Franke, L., Frayling, T., Gharib, S. A., Gibson, G., Heijmans, B. T., Hemani, G., Jansen, R., Kahonen, M., Kalnapenkis, A., Kasela, S., Kettunen, J., Kim, Y., Kirsten, H., Kovacs, P., Krohn, K., Kronberg, J., Kukushkina, V., Kutalik, Z., Lee, B., Lehtimaki, T., Loeffler, M., Marigorta, U. M., Mei, H., Milani, L., Montgomery, G. W., Muller-Nurasyid, M., Nauck, M., Nivard, M. G., Penninx, B. W. J. H., Perola, M., Pervjakova, N., Pierce, B. L., Powell, J., Prokisch, H., Psaty, B. M., Raitakari, O. T., Ripatti, S., Rotzschke, O., Rueger, S., Saha, A., Scholz, M., Schramm, K., Seppala, I., Slagboom, E. P., Stehouwer, C. D. A., Stumvoll, M., Sullivan, P., 't Hoen, P. A. C., Teumer, A., Thiery, J., Tong, L., Tonjes, A., van Dongen, J., van Iterson, M., van Meurs, J., Veldink, J. H., Verlouw, J., Visscher, P. M., Volker, U., Vosa, U., Westra, H. -J., Wijmenga, C., Yaghootkar, H., Yang, J., Zeng, B., Zhang, F., van Greevenbroek, M. M. J., Schalkwijk, C. G., Deelen, J., van Heemst, D., van Duijn, C. M., Hofman, B. A., Isaacs, A., Uitterlinden, A. G., Verbiest, M., Suchiman, H. E. D., Verkerk, M., van der Breggen, R., van Rooij, J., Lakenberg, N., Bot, J., Zhernakova, D. V., Luijk, R., Bonder, M. J., Swertz, M. A., van Zwet, E. W., Akimova, E. T., Bergmann, S., Boardman, J. D., Buring, J. E., Cesarini, D., Chasman, D. I., Chavarro, J. E., Cocca, M., Concas, M. P., Davey-Smith, G., Davies, G., Deary, I. J., Gaskins, A. J., de Geus, E. J. C., Gieger, C., Girotto, G., Grabe, H. J., Gunderson, E. P., Harris, K. M., Hartwig, F. P., He, C., Homuth, G., Horta, B. L., Jan Hottenga, J., Huang, H., Hyppӧnen, E., Ikram, M. A., Johannesson, M., Kamali, Z., Kavousi, M., Kraft, P., Kuhnel, B., Langenberg, C., Study, L. C., Lind, P. A., Luan, J., Magi, R., Magnusson, P. K. E., Mahajan, A., Martin, N. G., Mbarek, H., Mccarthy, M. I., Mcmahon, G., Mcqueen, M. B., Medland, S. E., Meitinger, T., Metspalu, A., Mihailov, E., Missmer, S. A., Mollegaard, S., Mook-Kanamori, D. O., Morgan, A., van der Most, P. J., de Mutsert, R., Noordam, R., Power, C., Redmond, P., Rich-Edwards, J. W., Ridker, P. M., Rietveld, C. A., Ring, S. M., Rose, L. M., Rueedi, R., Stefansson, K., Stockl, D., Strauch, K., Thurik, A. R., Timpson, N. J., Turman, C., Wareham, N. J., Willemsen, G., Zhao, J. H., Pers, T. H., Snieder, H., Perry, J. R. B., Ong, K. K., den Hoed, M., Barban, N., Day, F. R., Mills, Melinda C, Tropf, Felix C, Brazel, David M, van Zuydam, Natalie, Vaez, Ahmad, Pers, Tune H, Snieder, Harold, Perry, John RB, Ong, Ken K, den Hoed, Marcel, Barban, Nicola, Day, Felix R, Hyppӧnen, Elina, eQTLGen Consortium, BIOS Consortium, Human Reproductive Behaviour Consortium, Psychiatry, APH - Mental Health, Amsterdam Neuroscience - Complex Trait Genetics, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, APH - Digital Health, Consortium, eQTLGen, Consortium, BIOS, Consortium, Human Reproductive Behaviour, Mahajan, A, McCarthy, MI, Mills, Melinda C., Tropf, Felix C., Brazel, David M., Agbessi, Mawussé, Ahsan, Habibul, Alves, Isabel, Andiappan, Anand Kumar, Arindrarto, Wibowo, Awadalla, Philip, Battle, Alexi, Beutner, Frank, Jan Bonder, Marc, Boomsma, Dorret I., Christiansen, Mark W., Claringbould, Annique, Deelen, Patrick, Esko, Tõnu, Favé, Marie-Julie, Franke, Lude, Frayling, Timothy, Gharib, Sina A., Gibson, Greg, Heijmans, Bastiaan T., Hemani, Gibran, Jansen, Rick, Kähönen, Mika, Kalnapenkis, Anette, Kasela, Silva, Kettunen, Johanne, Kim, Yungil, Kirsten, Holger, Kovacs, Peter, Krohn, Knut, Kronberg, Jaanika, Kukushkina, Viktorija, Kutalik, Zoltan, Lee, Bernett, Lehtimäki, Terho, Loeffler, Marku, Marigorta, Urko M., Mei, Hailang, Milani, Lili, Montgomery, Grant W., Müller-Nurasyid, Martina, Nauck, Matthia, Nivard, Michel G., Penninx, Brenda W. J. H., Perola, Marku, Pervjakova, Natalia, Pierce, Brandon L., Powell, Joseph, Prokisch, Holger, Psaty, Bruce M., Raitakari, Olli T., Ripatti, Samuli, Rotzschke, Olaf, Rüeger, Sina, Saha, Ashi, Scholz, Marku, Schramm, Katharina, Seppälä, Ilkka, Slagboom, Eline P., Stehouwer, Coen D. A., Stumvoll, Michael, Sullivan, Patrick, ‘t Hoen, Peter A. C., Teumer, Alexander, Thiery, Joachim, Tong, Lin, Tönjes, Anke, van Dongen, Jenny, van Iterson, Maarten, van Meurs, Joyce, Veldink, Jan H., Verlouw, Joost, Visscher, Peter M., Völker, Uwe, Võsa, Urmo, Westra, Harm-Jan, Wijmenga, Cisca, Yaghootkar, Hanieh, Yang, Jian, Zeng, Biao, Zhang, Futao, Isaacs, Aaron, Pool, René, Jan Hottenga, Jouke, van Greevenbroek, Marleen M. J., van der Kallen, Carla J. H., Schalkwijk, Casper G., Zhernakova, Sasha, Tigchelaar, Ettje F., Beekman, Marian, Deelen, Jori, van Heemst, Diana, van den Berg, Leonard H., van Duijn, Cornelia M., Hofman, Bert A., Uitterlinden, André G., Jhamai, P. 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B., Ong, Ken K., Day, Felix R., Sociology [until 2010], Biological Psychology, APH - Methodology, Sociology and Social Gerontology, APH - Personalized Medicine, APH - Health Behaviors & Chronic Diseases, Management and Organisation, Urology, Medical Informatics, Department of Marketing Management, Epidemiology, Internal Medicine, Radiology & Nuclear Medicine, Neurology, Applied Economics, and Life Course Epidemiology (LCE)

Subjects
Male, demography, genetic variants, reproductive biology, externalising behavior, environmental effects, Disease, Genome-wide association studies, Behavioral Neuroscience, 0302 clinical medicine, genetics, media_common, fertility, 0303 health sciences, Reproduction, Incidence (epidemiology), Coitus, Age Factors, Longevity, sexual intercourse, health, Spermatid differentiation, Single Nucleotide, Reproduction/genetics, 3. Good health, Behavioural genetics, Parturition/genetics, Female, infertility, Infertility, genetic variant, Adolescent, Social Psychology, media_common.quotation_subject, Experimental and Cognitive Psychology, Polymorphism, Single Nucleotide, Article, 03 medical and health sciences, SDG 3 - Good Health and Well-being, Reproductive biology, medicine, Humans, Polymorphism, behavioural genetics, first sexual intercourse, Genetic Association Studies, Demography, 030304 developmental biology, Parturition, Coitus/physiology, medicine.disease, externalising behaviour, Sexual intercourse, Fertility, age, 030217 neurology & neurosurgery, first birth
Abstract

Age at first sexual intercourse and age at first birth have implications for health and evolutionary fitness. In this genome-wide association study (age at first sexual intercourse, N = 387,338; age at first birth, N = 542,901), we identify 371 single-nucleotide polymorphisms, 11 sex-specific, with a 5–6% polygenic score prediction. Heritability of age at first birth shifted from 9% [CI = 4–14%] for women born in 1940 to 22% [CI = 19–25%] for those born in 1965. Signals are driven by the genetics of reproductive biology and externalising behaviour, with key genes related to follicle stimulating hormone (FSHB), implantation (ESR1), infertility and spermatid differentiation. Our findings suggest that polycystic ovarian syndrome may lead to later age at first birth, linking with infertility. Late age at first birth is associated with parental longevity and reduced incidence of type 2 diabetes and cardiovascular disease. Higher childhood socioeconomic circumstances and those in the highest polygenic score decile (90%+) experience markedly later reproductive onset. Results are relevant for improving teenage and late-life health, understanding longevity and guiding experimentation into mechanisms of infertility.

Published
2021
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49. Reply to Helle et al

Author

Cesarini, David A., Lindqvist, Erik, and Wallace, Björn

Published
2010

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