1. Evidence of Zika Virus Reinfection by Genome Diversity and Antibody Response Analysis, Brazil.
- Author
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da Costa Castilho, Marcia, Bispo de Filippis, Ana Maria, Ceschini Machado, Lais, Vasconcelos de Lima Calvanti, Thaise Yasmine, Costa Lima, Morganna, Fonseca, Vagner, Giovanetti, Marta, Docena, Cassia, Menezes Neto, Armando, Aguiar Bôtto-Menezes, Camila Helena, Oliveira Kara, Edna, de La Barrera, Rafael, Modjarrad, Kayvon, Pereira Giozza, Silvana, Fernando Pereira, Gerson, Junior Alcantara, Luiz Carlos, Nicole Broutet, Nathalie Jeanne, Amaral Calvet, Guilherme, Luz Wallau, Gabriel, and Oliveira Franca, Rafael Freitas
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ANTIBODY diversity , *ZIKA virus , *ANTIBODY formation , *ZIKA virus infections , *REINFECTION , *ANTICARDIOLIPIN antibodies - Abstract
We generated 238 Zika virus (ZIKV) genomes from 135 persons in Brazil who had samples collected over 1 year to evaluate virus persistence. Phylogenetic inference clustered the genomes together with previously reported ZIKV strains from northern Brazil, showing that ZIKV has been remained relatively stable over time. Temporal phylogenetic analysis revealed limited within-host diversity among most ZIKV-persistent infected associated samples. However, we detected unusual virus temporal diversity from >5 persons, uncovering the existence of divergent genomes within the same patient. All those patients showed an increase in neutralizing antibody levels, followed by a decline at the convalescent phase of ZIKV infection. Of interest, in 3 of those patients, titers of neutralizing antibodies increased again after 6 months of ZIKV infection, concomitantly with real-time reverse transcription PCR re-positivity, supporting ZIKV reinfection events. Altogether, our findings provide evidence for the existence of ZIKV reinfection events. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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