30 results on '"Ceska, Tom"'
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2. A conformation-selective monoclonal antibody against a small molecule-stabilised signalling-deficient form of TNF
3. Cycloalkane-modified amphiphilic polymers provide direct extraction of membrane proteins for CryoEM analysis
4. Crystal structure of dopamine D1 receptor in complex with G protein and a non-catechol agonist
5. Structural insights into the disruption of TNF-TNFR1 signalling by small molecules stabilising a distorted TNF
6. Crystal structure of the adenosine A 2A receptor bound to an antagonist reveals a potential allosteric pocket
7. Small molecules that inhibit TNF signalling by stabilising an asymmetric form of the trimer
8. Discovery and Characterization of a Novel Series of Chloropyrimidines as Covalent Inhibitors of the Kinase MSK1
9. GPCR structure, function, drug discovery and crystallography: report from Academia-Industry International Conference (UK Royal Society) Chicheley Hall, 1–2 September 2014
10. Structural basis for recognition of synaptic vesicle protein 2C by botulinum neurotoxin A
11. Cycloalkane-modified amphiphilic polymers provide direct extraction of membrane proteins for CryoEM analysis
12. Engineering the Fab fragment of the anti-IgE omalizumab to prevent Fab crystallization and permit IgE-Fc complex crystallization
13. Correction: Cryo-EM in drug discovery
14. Cryo-EM in drug discovery
15. Allosteric mechanism of action of the therapeutic anti-IgE antibody omalizumab
16. Structural basis for recognition of synaptic vesicle protein 2C by botulinum neurotoxin A
17. Small molecules that inhibit TNF signalling by stabilising an asymmetric form of the trimer.
18. Discovery of a Potent, Orally Bioavailable PI4KIIIβ Inhibitor (UCB9608) Able To Significantly Prolong Allogeneic Organ Engraftment in Vivo
19. Allosteric mechanism of action of the therapeutic anti-IgE antibody omalizumab
20. Computational design of an epitope-specific Keap1 binding antibody using hotspot residues grafting and CDR loop swapping
21. Extending the half-life of a fab fragment through generation of a humanized anti-human serum albumin Fv domain: An investigation into the correlation between affinity and serum half-life
22. Direct observation of DNA threading in flap endonuclease complexes
23. Structural basis for recognition of synaptic vesicle protein 2C by botulinum neurotoxin A
24. Crystal structure of the adenosine A2A receptor bound to an antagonist reveals a potential allosteric pocket.
25. Inside Cover: Binding Mode and Structure–Activity Relationships around Direct Inhibitors of the Nrf2–Keap1 Complex (ChemMedChem 4/2014)
26. Binding Mode and Structure–Activity Relationships around Direct Inhibitors of the Nrf2–Keap1 Complex
27. Achieving multi-isoform PI3K inhibition in a series of substituted 3,4-dihydro-2H-benzo[1,4]oxazines
28. Synthesis and SAR of aminopyrimidines as novel c-Jun N-terminal kinase (JNK) inhibitors
29. GPCR structure, function, drug discovery and crystallography: report from Academia-Industry International Conference (UK Royal Society) Chicheley Hall, 1–2 September 2014
30. Recognition of protein surfaces by aromatic oligoamide foldamers
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