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2 results on '"Cetare Mohsenzadeh-Green"'

1. Characterization of Adaptive-like γδ T Cells in Ugandan Infants during Primary Cytomegalovirus Infection

Author

Jessica Tuengel, Sanya Ranchal, Alexandra Maslova, Gurpreet Aulakh, Maria Papadopoulou, Sibyl Drissler, Bing Cai, Cetare Mohsenzadeh-Green, Hugo Soudeyns, Sara Mostafavi, Peter van den Elzen, David Vermijlen, Laura Cook, and Soren Gantt

Subjects
CMV, gamma delta T cell, gammadelta, Vδ1, Vδ3, Vγ8, Microbiology, QR1-502
Abstract

Gamma-delta (γδ) T cells are unconventional T cells that help control cytomegalovirus (CMV) infection in adults. γδ T cells develop early in gestation, and a fetal public γδ T cell receptor (TCR) clonotype is detected in congenital CMV infections. However, age-dependent γδ T cell responses to primary CMV infection are not well-understood. Flow cytometry and TCR sequencing was used to comprehensively characterize γδ T cell responses to CMV infection in a cohort of 32 infants followed prospectively from birth. Peripheral blood γδ T cell frequencies increased during infancy, and were higher among CMV-infected infants relative to uninfected. Clustering analyses revealed associations between CMV infection and activation marker expression on adaptive-like Vδ1 and Vδ3, but not innate-like Vγ9Vδ2 γδ T cell subsets. Frequencies of NKG2C+CD57+ γδ T cells were temporally associated with the quantity of CMV shed in saliva by infants with primary infection. The public γδ TCR clonotype was only detected in CMV-infected infants

Published
2021
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2. Characterization of Adaptive-like γδ T Cells in Ugandan Infants during Primary Cytomegalovirus Infection

Author

Cetare Mohsenzadeh-Green, Bing Cai, David Vermijlen, Hugo Soudeyns, Laura Cook, Maria Papadopoulou, Soren Gantt, Jessica Tuengel, Sara Mostafavi, Sibyl Drissler, Gurpreet Aulakh, Peter van den Elzen, Alexandra Maslova, and Sanya Ranchal

Subjects
Male, Vγ9negVδ2, Cytomegalovirus, Lymphocyte Activation, NKG2C, Cohort Studies, 0302 clinical medicine, HLA-E, T-Lymphocyte Subsets, Uganda, Prospective Studies, Gamma delta T cell, Pathologie maladies infectieuses, Child, Intraepithelial Lymphocytes, 0303 health sciences, education.field_of_study, medicine.diagnostic_test, Age Factors, CMV, virus diseases, Receptors, Antigen, T-Cell, gamma-delta, Flow Cytometry, QR1-502, gammadelta, 3. Good health, Infectious Diseases, medicine.anatomical_structure, Child, Preschool, Cytomegalovirus Infections, Vγ8, Female, Gammadelta, Adult, gamma delta T cell, T cell, Population, Congenital cytomegalovirus infection, Receptors, Antigen, T-Cell, Vδ3, Biology, Microbiology, Article, Flow cytometry, Vδ1, 03 medical and health sciences, Virology, medicine, Humans, education, 030304 developmental biology, Fetus, CCMV, immune ontogeny, T-cell receptor, Infant, Newborn, Infant, medicine.disease, Immune ontogeny, cCMV, Immunology, Sciences pharmaceutiques, 030215 immunology
Abstract

Gamma-delta (γδ) T cells are unconventional T cells that help control cytomegalovirus (CMV) infection in adults. γδ T cells develop early in gestation, and a fetal public γδ T cell receptor (TCR) clonotype is detected in congenital CMV infections. However, age-dependent γδ T cell responses to primary CMV infection are not well-understood. Flow cytometry and TCR sequencing was used to comprehensively characterize γδ T cell responses to CMV infection in a cohort of 32 infants followed prospectively from birth. Peripheral blood γδ T cell frequencies increased during infancy, and were higher among CMV-infected infants relative to uninfected. Clustering analyses revealed associations between CMV infection and activation marker expression on adaptive-like Vδ1 and Vδ3, but not innate-like Vγ9Vδ2 γδ T cell subsets. Frequencies of NKG2C+CD57+ γδ T cells were temporally associated with the quantity of CMV shed in saliva by infants with primary infection. The public γδ TCR clonotype was only detected in CMV-infected infants, SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2021

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