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Your search keyword '"Chabner, Karissa T."' showing total 13 results
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13 results on '"Chabner, Karissa T."'

1. Haematopoietic stem cells depend on G[α.sub.s]-mediated signalling to engraft bone marrow

Author

Adams, Gregor B., Alley, Ian R., Chung, Ung-il, Chabner, Karissa T., Jeanson, Nathaniel T., Celso, Cristina Lo, Marsters, Emily S., Chen, Min, Weinstein, Lee S., Lin, Charles P., Kronenberg, Henry M., and Scadden, David T.

Subjects
Bone marrow -- Transplantation, Hematopoietic stem cells -- Physiological aspects -- Properties -- Research -- Methods, Cellular signal transduction -- Physiological aspects -- Research -- Methods, Environmental issues, Science and technology, Zoology and wildlife conservation, Physiological aspects, Research, Properties, Methods
Abstract

Haematopoietic stem and progenitor cells (HSPCs) change location during development (1) and circulate in mammals throughout life 2, moving into and out of the bloodstream to engage bone marrow niches [...]

Published
2009

6. Therapeutic targeting of a stem cell niche

Author

Adams, Gregor B, primary, Martin, Roderick P, additional, Alley, Ian R, additional, Chabner, Karissa T, additional, Cohen, Kenneth S, additional, Calvi, Laura M, additional, Kronenberg, Henry M, additional, and Scadden, David T, additional

Published
2007
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10. Efficient generation of human T cells from a tissue-engineered thymic organoid

Author

Poznansky, Mark C., primary, Evans, Richard H., additional, Foxall, Russell B., additional, Olszak, Ivona T., additional, Piascik, Anita H., additional, Hartman, Kelly E., additional, Brander, Christian, additional, Meyer, Thomas H., additional, Pykett, Mark J., additional, Chabner, Karissa T., additional, Kalams, Spyros A., additional, Rosenzweig, Michael, additional, and Scadden, David T., additional

Published
2000
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11. Haematopoietic stem cells depend on Gαs-mediated signalling to engraft bone marrow.

Author

Adams, Gregor B., Alley, Ian R., Chung, Ung-il, Chabner, Karissa T., Jeanson, Nathaniel T., Lo Celso, Cristina, Marsters, Emily S., Chen, Min, Weinstein, Lee S., Lin, Charles P., Kronenberg, Henry M., and Scadden, David T.

Subjects
STEM cell research, BONE grafting, BONE marrow, FETAL development, G proteins, LABORATORY mice, CHEMOTAXIS, CYTOKINES
Abstract

Haematopoietic stem and progenitor cells (HSPCs) change location during development and circulate in mammals throughout life, moving into and out of the bloodstream to engage bone marrow niches in sequential steps of homing, engraftment and retention. Here we show that HSPC engraftment of bone marrow in fetal development is dependent on the guanine-nucleotide-binding protein stimulatory α subunit (Gαs). HSPCs from adult mice deficient in Gαs (Gαs-/-) differentiate and undergo chemotaxis, but also do not home to or engraft in the bone marrow in adult mice and demonstrate a marked inability to engage the marrow microvasculature. If deleted after engraftment, Gαs deficiency did not lead to lack of retention in the marrow, rather cytokine-induced mobilization into the blood was impaired. Testing whether activation of Gαs affects HSPCs, pharmacological activators enhanced homing and engraftment in vivo. Gαs governs specific aspects of HSPC localization under physiological conditions in vivo and may be pharmacologically targeted to improve transplantation efficiency. [ABSTRACT FROM AUTHOR]

Published
2009
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12. Corrigendum: Therapeutic targeting of a stem cell niche.

Author

Adams, Gregor B., Martin, Roderick P., Alley, Ian R., Chabner, Karissa T., Cohen, Kenneth S., Calvi, Laura M., Kronenberg, Henry M., and Scadden, David T.

Subjects
STEM cell treatment
Abstract

A correction to the article "Therapeutic Targeting of a Stem Cell Niche" that was published in the January 21, 2007 issue is presented.

Published
2008
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13. Corrigendum: Therapeutic targeting of a stem cell niche.

Author

Adams, Gregor B, Martin, Roderick P, Alley, Ian R, Chabner, Karissa T, Cohen, Kenneth S, Calvi, Laura M, Kronenberg, Henry M, and Scadden, David T

Subjects
STEM cells
Abstract

This article presents a correction of the January 2007 issue regarding a paper on targeting stem cell niches.

Published
2007
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