232 results on '"Chackalamannil, Samuel"'
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2. Preface
3. Case History: Vorapaxar (Zontivity®): A First-in-class Protease-activated Receptor-1 (PAR-1) Antagonist Antiplatelet Agent
4. Discovery of hydroxy pyrimidine Factor IXa inhibitors
5. Antiplatelet Agents
6. Direct plasma analysis of drug compounds using monolithic column liquid chromatography and tandem mass spectrometry
7. The Discovery of Vorapaxar (SCH 530348), a Thrombin Receptor (Protease Activated Receptor-1) Antagonist with Potent Antiplatelet Effects
8. Synthesis of mono- and difluoronaphthoic acids
9. Stereochemistry of the oxidation of imines derived from substtituted cyclohexanones: axial vs equatorial attack and evidence for delivery by an adjacent hydroxyl group
10. Total synthesis of (+)-himbacine and (+)-himbeline
11. Discovery of MK-8282 as a Potent G-Protein-Coupled Receptor 119 Agonist for the Treatment of Type 2 Diabetes
12. Asymmetric synthesis of substituted 2-azaspiro(3.5)nonan-1-ones: an enantioselective synthesis of the cholesterol absorption inhibitor (+)-SCH 54016
13. Design, synthesis, and structure-activity relationship studies of himbacine derived muscarinic receptor antagonists
14. Total synthesis of (-)-himgaline
15. Design and Synthesis of P2–P4 Macrocycles Containing a Unique Spirocyclic Proline: A New Class of HCV NS3/4A Inhibitors
16. Discovery of nor-seco himbacine analogs as thrombin receptor antagonists
17. Vorapaxar: From Lead Identification to FDA Approval
18. Discovery of MK-8831, A Novel Spiro-Proline Macrocycle as a Pan-Genotypic HCV-NS3/4a Protease Inhibitor
19. Discovery of a nortropanol derivative as a potent and orally active GPR119 agonist for type 2 diabetes
20. Azabicyclic sulfonamides as potent 11β-HSD1 inhibitors
21. Diaryl piperidines as CB 1 receptor antagonists
22. The discovery of azepane sulfonamides as potent 11β-HSD1 inhibitors
23. A highly efficient total synthesis of (+)-himbacine
24. Himbacine-Derived Thrombin Receptor Antagonists: C7-Spirocyclic Analogues of Vorapaxar
25. Novel Quinoline-Based P2–P4 Macrocyclic Derivatives As Pan-Genotypic HCV NS3/4a Protease Inhibitors
26. Himbacine-Derived Thrombin Receptor Antagonists: C7-Aminomethyl and C9a-Hydroxy Analogues of Vorapaxar
27. Biaryl and heteroaryl derivatives of SCH 58261 as potent and selective adenosine A 2A receptor antagonists
28. Design, synthesis, and evaluation of fused heterocyclic analogs of SCH 58261 as adenosine A 2A receptor antagonists
29. Discovery of a vorapaxar analog with increased aqueous solubility
30. Antiplatelet Agents
31. ChemInform Abstract: Design, Synthesis, and Structure-Activity Relationship Studies of Himbacine Derived Muscarinic Receptor Antagonists.
32. ChemInform Abstract: Total Synthesis of (+)-Himbacine and (+)-Himbeline.
33. ChemInform Abstract: A Facile Diels-Alder Route to Dihydronaphthofuranones.
34. ChemInform Abstract: Total Synthesis of Himandravine.
35. ChemInform Abstract: Synthesis of Mono- and Difluoronaphthoic Acids.
36. Diaryl piperidines as CB1 receptor antagonists
37. Himbacine derived thrombin receptor (PAR-1) antagonists: SAR of the pyridine ring
38. The Role of Exploratory Drug Metabolism and Pharmacokinetics in New Drug Research: Case Study-Selection of a Thrombin Receptor Antagonist for Development
39. Himbacine derived thrombin receptor antagonists: Discovery of a new tricyclic core
40. Design, synthesis, and evaluation of fused heterocyclic analogs of SCH 58261 as adenosine A2A receptor antagonists
41. Biaryl and heteroaryl derivatives of SCH 58261 as potent and selective adenosine A2A receptor antagonists
42. Discovery of a Novel, Orally Active Himbacine-Based Thrombin Receptor Antagonist (SCH 530348) with Potent Antiplatelet Activity
43. Identification of Novel Cannabinoid CB1 Receptor Antagonists by Using Virtual Screening with a Pharmacophore Model
44. Heterotricyclic Himbacine Analogs as Potent, Orally Active Thrombin Receptor (Protease Activated Receptor-1) Antagonists
45. Total Synthesis of (‐)‐Himgaline (I).
46. Metabolism-Based Identification of a Potent Thrombin Receptor Antagonist
47. Thrombin Receptor (Protease Activated Receptor‐1) Antagonists as Potent Antithrombotic Agents with Strong Antiplatelet Effects
48. Total Synthesis of (−)-Himgaline
49. Himbacine derived thrombin receptor (PAR-1) antagonists: Structure–activity relationship of the lactone ring
50. Thrombin receptor (PAR-1) antagonists as novel antithrombotic agents
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