Search

Your search keyword '"Chacon, Alexander C."' showing total 20 results
Start Over Author "Chacon, Alexander C."
20 results on '"Chacon, Alexander C."'

5. Abstract 1605: "Reverse abscopal effect": Immunologically cold tumors alter systemic immunity and confer PD-1 resistance to immunologically hot tumors in synchronous melanoma

Author

Qin, Shuyang S., primary, Han, Booyeon J., additional, Chacon, Alexander C., additional, Melucci, Alexa D., additional, Williams, Alyssa R., additional, Jewell, Rachel, additional, Kim, Minsoo, additional, Linehan, David C., additional, Gerber, Scott A., additional, and Prieto, Peter A., additional

Published
2022
Full Text
View/download PDF

8. The impact of CA 19-9 on survival in patients with clinical stage I pancreatic cancer.

Author

Melucci, Alexa D., primary, Chacon, Alexander C, additional, Burchard, Paul R., additional, Ullman, Nicholas A., additional, Tsagkalidis, Vasleios, additional, Casabianca, Anthony S., additional, Reitz, Alexandra, additional, Swift, David A., additional, Goyal, Subir, additional, Switchenko, Jeffrey M., additional, Carpizo, Darren R., additional, and Shah, Mihir Maheshkumar, additional

Published
2022
Full Text
View/download PDF

12. Association of suboptimal lymph node yield with inferior survival in resected stage 1 colon cancer patients.

Author

Chacon, Alexander C, primary, Melucci, Alexa D., additional, Ullman, Nicholas A., additional, Burchard, Paul, additional, Casabianca, Anthony S., additional, Reitz, Alexandra, additional, Swift, David A., additional, Tsagkalidis, Vasileios, additional, Switchenko, Jeffrey M., additional, Goyal, Subir, additional, Carpizo, Darren R., additional, and Shah, Mihir Maheshkumar, additional

Published
2021
Full Text
View/download PDF

13. Intertumoral Genetic Heterogeneity Generates Distinct Tumor Microenvironments in a Novel Murine Synchronous Melanoma Model

Author

Qin, Shuyang S., primary, Han, Booyeon J., additional, Williams, Alyssa, additional, Jackson, Katherine M., additional, Jewell, Rachel, additional, Chacon, Alexander C., additional, Lord, Edith M., additional, Linehan, David C., additional, Kim, Minsoo, additional, Reuben, Alexandre, additional, Gerber, Scott A., additional, and Prieto, Peter A., additional

Published
2021
Full Text
View/download PDF

16. Intertumoral Genetic Heterogeneity Generates Distinct Tumor Microenvironments in a Novel Murine Synchronous Melanoma Model

Author

Qin, Shuyang S., primary, Han, Booyeon J., additional, Williams, Alyssa, additional, Jackson, Katherine M., additional, Jewell, Rachel, additional, Chacon, Alexander C., additional, Lord, Edith M., additional, Linehan, David C., additional, Kim, Minsoo, additional, Reuben, Alexandre, additional, Gerber, Scott A., additional, and Prieto, Peter A., additional

Published
2020
Full Text
View/download PDF

19. Effects of acute lipid overload on skeletal muscle insulin resistance, metabolic flexibility, and mitochondrial performance

Author

Dubé, John J., primary, Coen, Paul M., additional, DiStefano, Giovanna, additional, Chacon, Alexander C., additional, Helbling, Nicole L., additional, Desimone, Marisa E., additional, Stafanovic-Racic, Maja, additional, Hames, Kazanna C., additional, Despines, Alex A., additional, Toledo, Frederico G. S., additional, and Goodpaster, Bret H., additional

Published
2014
Full Text
View/download PDF

20. Effects of acute lipid overload on skeletal muscle insulin resistance, metabolic flexibility, and mitochondrial performance.

Author

Dubé JJ, Coen PM, DiStefano G, Chacon AC, Helbling NL, Desimone ME, Stafanovic-Racic M, Hames KC, Despines AA, Toledo FG, and Goodpaster BH

Subjects
Adult, Cell Respiration drug effects, Emulsions pharmacology, Energy Metabolism drug effects, Female, Glucose Clamp Technique, Humans, Male, Mitochondria, Muscle physiology, Phospholipids pharmacology, Soybean Oil pharmacology, Time Factors, Young Adult, Insulin Resistance, Lipids administration & dosage, Mitochondria, Muscle drug effects, Muscle, Skeletal drug effects, Muscle, Skeletal metabolism
Abstract

We hypothesized that acute lipid-induced insulin resistance would be attenuated in high-oxidative muscle of lean trained (LT) endurance athletes due to their enhanced metabolic flexibility and mitochondrial capacity. Lean sedentary (LS), obese sedentary (OS), and LT participants completed two hyperinsulinemic euglycemic clamp studies with and without (glycerol control) the coinfusion of Intralipid. Metabolic flexibility was measured by indirect calorimetry as the oxidation of fatty acids and glucose during fasted and insulin-stimulated conditions, the latter with and without lipid oversupply. Muscle biopsies were obtained for mitochondrial and insulin-signaling studies. During hyperinsulinemia without lipid, glucose infusion rate (GIR) was lowest in OS due to lower rates of nonoxidative glucose disposal (NOGD), whereas state 4 respiration was increased in all groups. Lipid infusion reduced GIR similarly in all subjects and reduced state 4 respiration. However, in LT subjects, fat oxidation was higher with lipid oversupply, and although glucose oxidation was reduced, NOGD was better preserved compared with LS and OS subjects. Mitochondrial performance was positively associated with better NOGD and insulin sensitivity in both conditions. We conclude that enhanced mitochondrial performance with exercise is related to better metabolic flexibility and insulin sensitivity in response to lipid overload., (Copyright © 2014 the American Physiological Society.)

Published
2014
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results