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783 results on '"Chae JI"'

1. Autophagy induction promotes renal cyst growth in polycystic kidney disease

Author

Eun Ji Lee, Je Yeong Ko, Sumin Oh, Jaehee Jun, Hyowon Mun, Chae Ji Lim, Seungwoon Seo, Hyuk Wan Ko, Hyunho Kim, Yun Kyu Oh, Curie Ahn, Minyong Kang, Min Jung Kim, Kyung Hyun Yoo, Goo Taeg Oh, and Jong Hoon Park

Subjects
Polycystic kidney, PKD, Autophagy, Ift46, Medicine, Medicine (General), R5-920
Abstract

Background: Polycystic kidney disease (PKD) involves renal cysts arising from proliferating tubular cells. Autophagy has been recently suggested as a potential therapeutic target in PKD, and mammalian target of rapamycin (mTOR) is a key negative regulator of autophagy. However, the effect of autophagy regulation on cystogenesis has not been elucidated in PKD mice. Methods: Clinical validation was performed using GEO datasets and autosomal dominant polycystic kidney disease (ADPKD) patient samples. Newly established PKD and LC3 transgenic mice were used for in vivo verifications, and additional tests were performed in vitro and in vivo using multiple autophagy drugs. Findings: Neither autophagy stimulation nor LC3 overexpression alleviated PKD. Furthermore, we observed the inhibitory effect of an autophagy inhibitor on cysts, indicating its possible therapeutic use in a specific group of patients with ADPKD. Interpretation: Our findings provide a novel insight into the pathogenesis related to autophagy in PKD, suggesting that drugs related to autophagy regulation should be considered with caution for treating PKD. Funding Sources: This work was supported by grants from the Bio & Medical Technology Development Program; the Collaborative Genome Program for Fostering New Post-Genome Industry of the NRF; the Basic Science Program.

Published
2020
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2. Momentum-space Langevin dynamics of holographic Wilsonian RG flow: self-interacting massive scalar field theory

Author

Chae, Ji-seong and Oh, Jae-Hyuk

Subjects
High Energy Physics - Theory
Abstract

We explore mathematical relationship between holographic Wilsonian renormalization group(HWRG) and stochastic quantization(SQ) motivated by the similarity of the monotonicity in RG flow with Langevin dynamics of non-equilibrium thermodynamics. We look at scalar field theory in AdS space with its generic mass, self-interaction, and boundary deformation in the momentum space. Identifying the stochastic time $t$ with radial coordinate $r$ in AdS, we establish maps between the fictitious time evolution of stochastic multi point correlation function and the radial evolution of multi-trace deformation, which respectively, express the relaxation process of Langevin dynamics and holographic RG flow. We especially consider marginal multi-trace deformation on the AdS boundary which is successfully captured by a Langevin dynamics of SQ., Comment: 55+1 pages, 3 figures, typos are corrected, conclusion section is added

Published
2024

4. Stochastic quantization and holographic Wilsonian renormalization group of scalar theory with generic mass, self-interaction and multiple trace deformation

Author

Kim, Gitae, Chae, Ji-seong, Shin, WooCheol, and Oh, Jae-Hyuk

Subjects
High Energy Physics - Theory
Abstract

We explore the mathematical relationship between holographic Wilsonian renormalization group(HWRG) and stochastic quantization(SQ) of scalar field theory with its generic mass, self-interaction and $n$-multiple-trace deformation on the $d$-dimensional conformal boundary defined in AdS$_{d+1}$ spacetime. We understand that once we define our Euclidean action, $S_E$ as $S_E\equiv -2S_B$, then the stochastic process will reconstruct the holographic Wilsonian renormalization group data via solving Langevin equation and computing stochastic correlation functions. The $S_B$ is given by $S_B=S_{\rm ct}+S_{\rm def}$, where $S_{\rm ct}$ is the boundary counter term and $S_{\rm def}$ is the boundary deformation which gives a boundary condition. In our study, we choose the boundary condition adding (marginal)$n$-multiple trace deformation to the holographic dual field theory. In this theory, we establish maps bewteen ficticious time, $t$ evolution of stochastic $n$-point, ($2n-2$)-point correlation functions and the (AdS)radial, $r$ evolution of $n$-multiple-trace and ($2n-2$)-multiple-trace deformations respectively once we take identifications of $r=t$ and between some of constants appearing in both sides., Comment: 41 pages and 3 figures, typos are corrected

Published
2023
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5. Holographic entanglement entropy probe on spontaneous symmetry breaking with vector order

Author

Park, Chanyong, Kim, Gitae, Chae, Ji-seong, and Oh, Jae-Hyuk

Subjects
High Energy Physics - Theory
Abstract

We study holographic entanglement entropy in 5-dimensional charged black brane geometry obtained from Einstein-SU(2)Yang-Mills theory defined in asymptotically AdS space. This gravity system undergoes second order phase transition near its critical point affected by a spatial component of the Yang-Mills fields, which is normalizable mode of the solution. This is known as phase transition between isotropic and anisotropic phases. We get analytic solutions of holographic entanglement entropies by utilizing the solution of bulk spacetime geometry given in arXiv:1109.4592, where we consider subsystems defined on AdS boundary of which shapes are wide and thin slabs and a cylinder. It turns out that the entanglement entropies near the critical point shows scaling behavior such that for both of the slabs and cylinder, $\Delta_\varepsilon S\sim\left(1-\frac{T}{T_c}\right)^\beta$ and the critical exponent $\beta=1$, where $\Delta_\varepsilon S\equiv S^{iso}-S^{aniso}$, and $S^{iso}$ denotes the entanglement entropy in isotropic phase whereas $S^{aniso}$ denotes that in anisotropic phase. We suggest a quantity $O_{12}\equiv S_1-S_2$ as a new order parameter near the critical point, where $S_1$ is entanglement entropy when the slab is perpendicular to the direction of the vector order whereas $S_2$ is that when the slab is parallel to the vector order. $O_{12}=0$ in isotropic phase but in anisotropic phase, the order parameter becomes non-zero showing the same scaling behavior. Finally, we show that even near the critical point, the first law of entanglement entropy is hold. Especially, we find that the entanglement temperature for the cylinder is $\mathcal T_{cy}=\frac{c_{ent}}{a}$, where $c_{ent}=0.163004\pm0.000001$ and $a$ is the radius of the cylinder., Comment: 1+29 pages, 4 figures, typos are corrected, a few paragraphs are added in introduction and discussion section is added

Published
2022
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15. Ocular tropism of SARS-CoV-2 in animal models with retinal inflammation via neuronal invasion following intranasal inoculation

Author

Jeong, Gi Uk, Kwon, Hyung-Jun, Ng, Wern Hann, Liu, Xiang, Moon, Hyun Woo, Yoon, Gun Young, Shin, Hye Jin, Lee, In-Chul, Ling, Zheng Lung, Spiteri, Alanna G., King, Nicholas J. C., Taylor, Adam, Chae, Ji Soo, Kim, Chonsaeng, Ahn, Dae-Gyun, Kim, Kyun-Do, Ryu, Young Bae, Kim, Seong-Jun, Mahalingam, Suresh, and Kwon, Young-Chan

Published
2022
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25. Association between Complex ACTN3 and ACE Gene Polymorphisms and Elite Endurance Sports in Koreans: A Case–Control Study.

Author

Chae, Ji Heon, Eom, Seon-Ho, Lee, Sang-Ki, Jung, Joo-Ha, and Kim, Chul-Hyun

Subjects
*ENDURANCE sports, *AEROBIC metabolism, *ENDURANCE athletes, *ELITE athletes, *GENETIC polymorphisms
Abstract

ACTN3 R577X and ACE I/D polymorphisms are associated with endurance exercise ability. This case–control study explored the association of ACTN3 and ACE gene polymorphisms with elite pure endurance in Korean athletes, hypothesizing that individuals with both ACTN3 XX and ACE II genotypes would exhibit superior endurance. We recruited 934 elite athletes (713 males, 221 females) and selected 45 pure endurance athletes (36 males, 9 females) requiring "≥90% aerobic energy metabolism during sports events", in addition to 679 healthy non-athlete Koreans (361 males, 318 females) as controls. Genomic DNA was extracted and genotyped for ACTN3 R577X and ACE I/D polymorphisms. ACE ID (p = 0.090) and ACTN3 RX+XX (p = 0.029) genotype distributions were significantly different between the two groups. Complex ACTN3-ACE genotypes also exhibited significant differences (p = 0.014), with dominant complex genotypes positively affecting endurance (p = 0.039). The presence of RX+II or XX+II was associated with a 1.763-fold higher likelihood of possessing a superior endurance capacity than that seen in healthy controls (90% CI = 1.037–3.089). Our findings propose an association of combined ACTN3 RX+XX and ACE II genotypes with enhanced endurance performance in elite Korean athletes. While causality remains to be confirmed, our study highlights the potential of ACTN3-ACE polymorphisms in predicting elite endurance. [ABSTRACT FROM AUTHOR]

Published
2024
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31. A Cell‐Penetrant Peptide Disrupting the Transcription Factor CP2c Complexes Induces Cancer‐Specific Synthetic Lethality

Author

Son, Seung Han, primary, Kim, Min Young, additional, Choi, Sungwoo, additional, Kim, Ji Sook, additional, Lee, Yong Sang, additional, Lee, Sangwon, additional, Lee, Yeon Ju, additional, Lee, Jin Youn, additional, Lee, Seol Eui, additional, Lim, Young Su, additional, Ha, Dae Hyun, additional, Oh, Eonju, additional, Won, Young‐Bin, additional, Ji, Chang‐Jun, additional, Park, Mi Ae, additional, Kim, Boram, additional, Byun, Kyu Tae, additional, Chung, Min Sung, additional, Jeong, Jaemin, additional, Choi, Dongho, additional, Baek, Eun Jung, additional, Cho, Eung‐Ho, additional, Kim, Sang‐Bum, additional, Je, A. Reum, additional, Kweon, Hee‐Seok, additional, Park, Hyun Sook, additional, Park, Dongsun, additional, Bae, June Sung, additional, Jang, Se Jin, additional, Yun, Chae‐Ok, additional, Chae, Ji Hyung, additional, Lee, Jin‐Won, additional, Lee, Su‐Jae, additional, Kim, Chan Gil, additional, Kang, Ho Chul, additional, Uversky, Vladimir N., additional, and Kim, Chul Geun, additional

Published
2023
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33. Predictive Value of Ultrasound-Measured Quadriceps Depth and Frailty Status for Hypotension in Older Patients Undergoing Reverse Total Shoulder Arthroplasty in the Beach Chair Position under General Anesthesia.

Author

An, Sang-Mee, Lee, Hyun Jung, Woo, Jae Hee, Chae, Ji Seon, and Shin, Sang-jin

Subjects
REVERSE total shoulder replacement, TOTAL shoulder replacement, OLDER patients, GENERAL anesthesia, QUADRICEPS muscle, RECEIVER operating characteristic curves
Abstract

The beach chair position (BCP) is widely used in shoulder surgery; however, it frequently leads to hypotension. Hypotension in BCP is prevalent among older patients who are at risk of secondary complications such as ischemic injuries. Therefore, this prospective study aimed to investigate the association and predictive value of frailty, as assessed by ultrasound-measured quadriceps depth and questionnaire, in patients aged ≥65 years undergoing elective shoulder surgery under general anesthesia. A multivariable logistic regression analysis was performed to identify independent risk factors for hypotension in BCP under general anesthesia. Receiver operating characteristic curves were constructed to assess the predictive values of various parameters. The results indicated that a quadriceps depth < 2.3 cm and BCP for an extended period significantly increased the risk of hypotension. The combined consideration of quadriceps depth < 2.3 cm and frailty demonstrated markedly superior predictive power compared with each factor individually. In conclusion, the study findings facilitate the screening and identification of risk factors for older patients undergoing surgery in BCP, thereby enhancing perioperative management. [ABSTRACT FROM AUTHOR]

Published
2024
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