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1. Risk factors for cancer in patients with primary biliary cholangitis and autoimmune hepatitis and primary biliary cholangitis overlap syndrome

Author

Braga, Michelle Harriz, Cançado, Guilherme Grossi Lopes, Bittencourt, Paulo Lisboa, Couto, Cláudia Alves, Guedes, Laura Vilar, Lima, André Mourão Costa, Ferraz, Maria Lucia Gomes, Villela-Nogueira, Cristiane Alves, Nardelli, Mateus Jorge, Faria, Luciana Costa, Gomes, Nathalia Mota de Faria, Oliveira, Elze Maria Gomes, Rotman, Vivian, Oliveira, Maria Beatriz, da Cunha, Simone Muniz Carvalho Fernandes, Cunha-Silva, Marlone, Mendes, Liliana Sampaio Costa, Ivantes, Claudia Alexandra Pontes, Codes, Liana, de Almeida e Borges, Valéria Ferreira, Pace, Fabio Heleno de Lima, Pessoa, Mario Guimarães, Signorelli, Izabelle Venturini, Coral, Gabriela Perdomo, Filho, João Galizzi, Chagas, Aline Lopes, Terrabuio, Debora Raquel Benedita, and Cançado, Eduardo Luiz Rachid

Published
2023
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2. International study on the outcome of locoregional therapy for liver transplant in hepatocellular carcinoma beyond Milan criteria

Author

Boudjema, Karim, Bachellier, Philippe, Conti, Filomena, Scatton, Olivier, Muscari, Fabrice, Salame, Ephrem, Bernard, Pierre Henri, Francoz, Claire, Durand, Francois, Dharancy, Sébastien, Woehl, Marie-lorraine, Vanlemmens, Claire, Laurent, Alexis, Radenne, Sylvie, Dumortier, Jérôme, Abergel, Armand, Cherqui, Daniel, Barbier, Louise, Houssel-Debry, Pauline, Pageaux, Georges Philippe, Chiche, Laurence, Deledinghen, Victor, Hardwigsen, Jean, Gugenheim, J., Altieri, M., Hilleret, Marie Noelle, Decaens, Thomas, Duvoux, Christophe, Piñero, Federico, Chagas, Aline, Costa, Paulo, Cristina de Ataide, Elaine, Quiñones, Emilio, Duque, Sergio Hoyos, Marciano, Sebastián, Anders, Margarita, Varón, Adriana, Zerega, Alina, Poniachik, Jaime, Soza, Alejandro, Machaca, Martín Padilla, Arufe, Diego, Menéndez, Josemaría, Zapata, Rodrigo, Vilatoba, Mario, Muñoz, Linda, Menéndez, Ricardo Chong, Maraschio, Martín, Podestá, Luis G., Fauda, M., Campaña, A. Gonzalez, McCormack, Lucas, Mattera, Juan, Gadano, Adrian, Fatima Boin, Ilka S.F., Parente García, Jose Huygens, Carrilho, Flair, Silva, Marcelo, Notarpaolo, Andrea, Magini, Giulia, Miglioresi, Lucia, Gambato, Martina, Di Benedetto, Fabrizio, D’Ambrosio, Cecilia, Ettorre, Giuseppe Maria, Vitale, Alessandro, Burra, Patrizia, Fagiuoli, Stefano, Cillo, Umberto, Colledan, Michele, Pinelli, Domenico, Magistri, Paolo, Vennarecci, Giovanni, Colasanti, Marco, Giannelli, Valerio, Pellicelli, Adriano, Baccaro, Cizia, Degroote, Helena, Van Vlierberghe, Hans, Eduard, Callebout, Samuele, Iesari, Jeroen, Dekervel, Jonas, Schreiber, Jacques, Pirenne, Chris, Verslype, Dirk, Ysebaert, Peter, Michielsen, Valerio, Lucidi, Christophe, Moreno, Olivier, Detry, Jean, Delwaide, Roberto, Troisi, Paul, Lerut Jan, Costentin, Charlotte, Boin, Ilka F., Baccaro, Cinzia, Chagas, Aline Lopes, Di Benedetto, Fabrio, Gadano, Adrián, and Rubinstein, Fernando

Published
2021
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4. O-43 RISK FACTORS FOR CANCER DEVELOPMENT IN PATIENTS WITH PRIMARY BILIARY CHOLANGITIS

Author

Braga, Michelle Harriz, primary, Cançado, Guilherme Grossi Lopes, additional, Bittencourt, Paulo Lisboa, additional, Couto, Cláudia Alves, additional, Guedes, Laura Vilar, additional, Lima, André Mourão Costa, additional, Ferraz, Maria Lucia Gomes, additional, Villela-Nogueira, Cristiane Alves, additional, Mateus, Jorge Nardelli, additional, Faria, Luciana Costa, additional, Gomes, Nathalia Mota De Faria, additional, Elze, Maria Gomes Oliveira, additional, Rotman, Vivian, additional, Oliveira, Maria Beatriz, additional, Cunha, Simone Muniz Carvalho Fernandes, additional, Cunha-Silva, Marlone, additional, Mendes, Liliana Sampaio Costa, additional, Ivantes, Claudia Alexandra Pontes, additional, Codes, Liana, additional, Borges, Valéria Ferreira De Almeida, additional, Pace, Fabio Heleno De Lima, additional, Pessoa, Mario Guimarães, additional, Signorelli, Izabelle Venturini, additional, Coral, Gabriela Perdomo, additional, Filho, João Galizzi, additional, Chagas, Aline Lopes, additional, Terrabuio, Debora Raquel Benedita, additional, and Cançado, Eduardo Luiz Rachid, additional

Published
2023
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6. Early variation of inflammatory indexes refines prognostic prediction in patients with hepatocellular carcinoma under systemic treatment

Author

Fonseca, Leonardo G, primary, Uratani, Lucas Fernando, additional, Soares, Gabriella Fernandes, additional, Amaral, Paulo Siqueira, additional, Alencar, Regiane Saraiva Souza Melo, additional, Chagas, Aline Lopes, additional, Alves, Venancio Avancini Ferreira, additional, and Carrilho, Flair Jose, additional

Published
2022
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9. Hepatocellular carcinoma (HCC) in patients with Non-Alcoholic Fatty Liver Disease (NAFLD): screening, treatment and survival analysis in a Brazilian series

Author

Alencar, Regiane Saraiva de Souza Melo, primary, Oliveira, Claudia P., additional, Chagas, Aline Lopes, additional, Fonseca, Leonardo Gomes da, additional, Maccali, Claudia, additional, Saud, Lisa Rodrigues da Cunha, additional, Xerfan, Mariana Pinheiro, additional, Stefano, Jose Tadeu, additional, Herman, Paulo, additional, D'Albuquerque, Luiz Augusto Carneiro, additional, Alves, Venâncio Avancini Ferreira, additional, and Carrilho, Flair Jose, additional

Published
2022
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10. O-15 ABSENCE OF DISEASE REMISSION AS A RISK FACTOR FOR HEPATOCELLULAR CARCINOMA IN PATIENTS WITH AUTOIMMUNE HEPATITIS

Author

Vaz, Nayana Fonseca, Margon, Julia Fadini, Moutinho, Bruna Damasio, Braga, Michele Harriz, Tani, Claudia Megumi, Alengar, Regiane Saraiva de Souza Melo, Saud, Lisa Rodrigues da Cunha, Vezozzo, Denise Cerqueira Paranaguá, Deguti, Marta, Horvat, Natally, Cançado, Eduardo Luiz Rachid, Carrilho, Flair Jose, Chagas, Aline Lopes, and Terrabuio, Débora

Published
2021
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11. O-4 IMPACT OF BRIDGE THERAPY FOR HEPATOCELLULAR CARCINOMA IN PATIENTS SUBMITTED TO LIVER TRANSPLANTATION - BRAZILIAN MULTICENTER STUDY

Author

Margon, Julia Fadini, Chagas, Aline Lopes, Mattos, Angelo A., Diniz, Márcio Augusto, Gonçalves Felga, Guilherme Eduardo, Boin, Ilka de Fátima Santana Ferreira, da Silva, Rita de Cássia Martins Alves, da Silva, Renato Ferreira, Garcia, José Huygens Parente, Lima, Agnaldo Soares, Coelho, Júlio Cezar Uili, Bittencourt, Paulo Lisboa, Ferreira Alves, Venâncio Avancini, Carneiro D'Albuquerque, Luiz Augusto, and Carrilho, Flair José

Published
2021
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12. International study on the outcome of locoregional therapy for liver transplant in hepatocellular carcinoma beyond Milan criteria

Author

Degroote, Helena, primary, Piñero, Federico, additional, Costentin, Charlotte, additional, Notarpaolo, Andrea, additional, Boin, Ilka F., additional, Boudjema, Karim, additional, Baccaro, Cinzia, additional, Chagas, Aline Lopes, additional, Bachellier, Philippe, additional, Ettorre, Giuseppe Maria, additional, Poniachik, Jaime, additional, Muscari, Fabrice, additional, Di Benedetto, Fabrio, additional, Duque, Sergio Hoyos, additional, Salame, Ephrem, additional, Cillo, Umberto, additional, Gadano, Adrián, additional, Vanlemmens, Claire, additional, Fagiuoli, Stefano, additional, Rubinstein, Fernando, additional, Burra, Patrizia, additional, Cherqui, Daniel, additional, Silva, Marcelo, additional, Van Vlierberghe, Hans, additional, Duvoux, Christophe, additional, Conti, Filomena, additional, Scatton, Olivier, additional, Bernard, Pierre Henri, additional, Francoz, Claire, additional, Durand, Francois, additional, Dharancy, Sébastien, additional, Woehl, Marie-lorraine, additional, Laurent, Alexis, additional, Radenne, Sylvie, additional, Dumortier, Jérôme, additional, Abergel, Armand, additional, Barbier, Louise, additional, Houssel-Debry, Pauline, additional, Pageaux, Georges Philippe, additional, Chiche, Laurence, additional, Deledinghen, Victor, additional, Hardwigsen, Jean, additional, Gugenheim, J., additional, Altieri, M., additional, Hilleret, Marie Noelle, additional, Decaens, Thomas, additional, Chagas, Aline, additional, Costa, Paulo, additional, Cristina de Ataide, Elaine, additional, Quiñones, Emilio, additional, Marciano, Sebastián, additional, Anders, Margarita, additional, Varón, Adriana, additional, Zerega, Alina, additional, Soza, Alejandro, additional, Machaca, Martín Padilla, additional, Arufe, Diego, additional, Menéndez, Josemaría, additional, Zapata, Rodrigo, additional, Vilatoba, Mario, additional, Muñoz, Linda, additional, Menéndez, Ricardo Chong, additional, Maraschio, Martín, additional, Podestá, Luis G., additional, Fauda, M., additional, Campaña, A. Gonzalez, additional, McCormack, Lucas, additional, Mattera, Juan, additional, Gadano, Adrian, additional, Fatima Boin, Ilka S.F., additional, Parente García, Jose Huygens, additional, Carrilho, Flair, additional, Magini, Giulia, additional, Miglioresi, Lucia, additional, Gambato, Martina, additional, Di Benedetto, Fabrizio, additional, D’Ambrosio, Cecilia, additional, Vitale, Alessandro, additional, Colledan, Michele, additional, Pinelli, Domenico, additional, Magistri, Paolo, additional, Vennarecci, Giovanni, additional, Colasanti, Marco, additional, Giannelli, Valerio, additional, Pellicelli, Adriano, additional, Baccaro, Cizia, additional, Degroote, Helena, additional, Eduard, Callebout, additional, Samuele, Iesari, additional, Jeroen, Dekervel, additional, Jonas, Schreiber, additional, Jacques, Pirenne, additional, Chris, Verslype, additional, Dirk, Ysebaert, additional, Peter, Michielsen, additional, Valerio, Lucidi, additional, Christophe, Moreno, additional, Olivier, Detry, additional, Jean, Delwaide, additional, Roberto, Troisi, additional, and Paul, Lerut Jan, additional

Published
2021
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13. Radiomic analysis of MRI to Predict Sustained Complete Response after Radiofrequency Ablation in Patients with Hepatocellular Carcinoma - A Pilot Study

Author

Horvat, Natally, primary, Araujo-Filho, Jose de Arimateia B., additional, Assuncao-Jr, Antonildes N., additional, Machado, Felipe Augusto de M., additional, Sims, John A., additional, Rocha, Camila Carlos Tavares, additional, Oliveira, Brunna Clemente, additional, Horvat, Joao Vicente, additional, Maccali, Claudia, additional, Puga, Anna Luísa Boschiroli Lamanna, additional, Chagas, Aline Lopes, additional, Menezes, Marcos Roberto, additional, and Cerri, Giovanni Guido, additional

Published
2021
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14. Hepatocellular carcinoma in patients with autoimmune hepatitis: prevalence and risk factors

Author

Vaz, Nayana Fonseca, primary, Margon, Julia Fadini, additional, Moutinho, Bruna Damasio, additional, Braga, Michele Harriz, additional, Tani, Claudia Megumi, additional, de Souza Melo Alencar, Regiane Saraiva, additional, da Cunha Saud, Lisa Rodrigues, additional, Paranaguá Vezozzo, Denise Cerqueira, additional, Deguti, Marta, additional, Horvat, Natally, additional, Rachid Cançado, Eduardo Luiz, additional, Carrilho, Flair Jose, additional, Chagas, Aline Lopes, additional, and Terrabuio, Débora, additional

Published
2020
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15. Management of Hepatocellular Carcinoma during the COVID-19 Pandemic - São Paulo Clínicas Liver Cancer Group Multidisciplinary Consensus Statement

Author

Chagas, Aline Lopes, primary, da Fonseca, Leonardo Gomes, additional, Coelho, Fabricio Ferreira, additional, da Cunha Saud, Lisa Rodrigues, additional, Abdala, Edson, additional, Andraus, Wellington, additional, Fiore, Lucas, additional, Moreira, Airton Mota, additional, Menezes, Marcos Roberto, additional, Carnevale, Francisco César, additional, Tani, Claudia Megumi, additional, Alencar, Regiane S.S.M, additional, D'Albuquerque, Luiz Augusto Carneiro, additional, Herman, Paulo, additional, and Carrilho, Flair José, additional

Published
2020
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16. BRAZILIAN SOCIETY OF HEPATOLOGY UPDATED RECOMMENDATIONS FOR DIAGNOSIS AND TREATMENT OF HEPATOCELLULAR CARCINOMA

Author

CHAGAS, Aline Lopes, primary, MATTOS, Angelo Alves de, additional, CARRILHO, Flair José, additional, BITTENCOURT, Paulo Lisboa, additional, VEZOZZO, Denise Cerqueira Paranaguá, additional, HORVAT, Natally, additional, ROCHA, Manoel de Souza, additional, ALVES, Venâncio Avancini Ferreira, additional, CORAL, Gabriela Perdomo, additional, ALVARES-DA-SILVA, Mario Reis, additional, BARROS, Fabio Marinho do Rego, additional, MENEZES, Marcos Roberto, additional, MONSIGNORE, Lucas Moretti, additional, COELHO, Fabricio Ferreira, additional, SILVA, Renato Ferreira da, additional, SILVA, Rita de Cássia Martins Alves, additional, BOIN, Ilka de Fatima Santana Ferreira, additional, D`ALBUQUERQUE, Luiz Augusto Carneiro, additional, GARCIA, José Huygens Parente, additional, FELGA, Guilherme Eduardo Gonçalves, additional, MOREIRA, Airton Mota, additional, BRAGHIROLI, Maria Ignez Freitas Melro, additional, HOFF, Paulo Marcelo Gehm, additional, MELLO, Vivianne Barretto de, additional, DOTTORI, Mariana Fonseca, additional, BRANCO, Tiago Pugliese, additional, SCHIAVON, Leonardo de Lucca, additional, and COSTA, Thaisa de Fátima Almeida, additional

Published
2020
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18. RECOMMENDATIONS FOR INVASIVE PROCEDURES IN PATIENTS WITH DISEASES OF THE LIVER AND BILIARY TRACT: REPORT OF A JOINT MEETING OF THE BRAZILIAN SOCIETY OF HEPATOLOGY (SBH), BRAZILIAN SOCIETY OF DIGESTIVE ENDOSCOPY (SOBED) AND BRAZILIAN SOCIETY OF INTERVENTIONAL RADIOLOGY AND ENDOVASCULAR SURGERY (SOBRICE)

Author

SCHIAVON, Leonardo de Lucca, primary, EJIMA, Flávio Hayato, additional, MENEZES, Marcos Roberto de, additional, BITTENCOURT, Paulo Lisboa, additional, MOREIRA, Aírton Mota, additional, FARIAS, Alberto Queiroz, additional, CHAGAS, Aline Lopes, additional, ASSIS, André Moreira de, additional, MATTOS, Ângelo Zambam de, additional, SALOMÃO, Bruno Chaves, additional, TERRA, Carlos, additional, MARTINS, Fernanda Prata Borges, additional, CARNEVALE, Francisco Cesar, additional, REZENDE, Guilherme Ferreira da Motta, additional, PAULO, Gustavo Andrade de, additional, PEREIRA, Gustavo Henrique Santos, additional, MOTTA-LEAL-FILHO, Joaquim Maurício da, additional, MENESES, Juliana de, additional, COSTA, Lucas Santana Nova da, additional, CARNEIRO, Marcos de Vasconcelos, additional, ÁLVARES-DA-SILVA, Mário Reis, additional, SOARES, Mayra Veloso Ayrimoraes, additional, PEREIRA, Osvaldo Ignácio, additional, XIMENES, Rafael Oliveira, additional, DURANTE, Renata Filardi Simiqueli, additional, FERREIRA, Valério Alves, additional, and LIMA, Vinícius Machado de, additional

Published
2019
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19. FRI-462-A multicenter international study of sorafenib treatment in patients with hepatocellular carcinoma and chronic kidney disease undergoing hemodialysis

Author

Diaz-Gonzalez, Alvaro, primary, Sanduzzi-Zamparelli, Marco, additional, Fonseca, Leonardo Gomes da, additional, Costanzo, Giovan Giuseppe Di, additional, Alves, Rogério, additional, Iavarone, Massimo, additional, Leal, Cassia Regina G, additional, Sacco, Rodolfo, additional, Matilla, Ana M, additional, Guerra, Manuel Hernández, additional, Soteras, Gabriel Alejandro Aballay, additional, Marcus, Worns, additional, Pinter, Matthias, additional, Varela, Maria, additional, Ladekarl, Morten, additional, Chagas, Aline Lopes, additional, Minguez, Beatriz, additional, Ignacio, Juan, additional, Ruiz-Tapiador, Arenas, additional, Granito, Alessandro, additional, Sánchez, Yolanda, additional, Rojas, Angela, additional, Lope, Carlos Rodriguez De, additional, Álvares-Da-Silva, Mario Reis, additional, Pascual, Sonia, additional, Rimassa, Lorenza, additional, Lledó, José Luis, additional, Huertas, Carlos, additional, Sangro, Bruno, additional, Giannini, Edoardo Giovanni, additional, Delgado, Manuel, additional, Gómez, Mercedes Vergara, additional, Perello, Christie, additional, Lué, Alberto, additional, Sala, Margarita, additional, Moya, Adolfo Gallego, additional, Coll, Susana, additional, Alsina, Tania Hernaez, additional, Pinero, Federico, additional, Pereira, Gustavo, additional, França, Alex Vianey Callado, additional, Marín, Juan, additional, Anders, Maria Margarita, additional, Mello, Vivianne, additional, Lozano, María Del Mar, additional, Nault, Jean Charles, additional, Menéndez, José María, additional, Juarez, Ignacio Garcia, additional, Bruix, Jordi, additional, and Reig, Maria, additional

Published
2019
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20. Multimodality Screening of Hepatic Nodules in Patients With Congenital Heart Disease After Fontan Procedure: Role of Ultrasound, ARFI Elastography, CT, and MRI

Author

Horvat, Natally, primary, Rocha, Manoel Souza, additional, Chagas, Aline Lopes, additional, Oliveira, Brunna Clemente, additional, Pacheco, Mariana Poltronieri, additional, Binotto, Maria Angélica, additional, Ikari, Nana Miura, additional, Paranaguá-Vezozzo, Denise Cerqueira, additional, Leao-Filho, Hilton Muniz, additional, Vicentini, João Rafael Terneira, additional, Moreira da Silva Filho, Mauricio Ricardo, additional, Jatene, Marcelo Biscegli, additional, Carrilho, Flair José, additional, and Cerri, Giovanni Guido, additional

Published
2018
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22. Epidemiology of Liver Cancer in Latin America: Current and Future Trends.

Author

Carrilho, Flair Jose, Paranaguá-Vezozzo, Denise Cerqueira, Chagas, Aline Lopes, Alencar, Regiane Saraiva de Souza Melo, and da Fonseca, Leonardo Gomes

Subjects
LIVER cancer, EPIDEMIOLOGY of cancer, ETIOLOGY of diseases, FATTY liver, HEPATITIS B virus, HEPATITIS B
Abstract

Over 38,000 cases of hepatocellular carcinoma (HCC) are estimated to occur in Latin America annually. The region is characterized by sociocultural heterogeneity and economic disparities, which impose barriers in addressing this major health issue. A significant proportion of patients are still diagnosed in the later stages of the disease, although efforts to implement effective screening programs have been reported by referral centers. While viral hepatitis remains the predominant etiology of liver disease among HCC cases in Latin America, a high prevalence of fatty liver disease in the region is a matter of concern, reflecting the current scenario in many Western countries. In addition, other risk factors such as alcohol, aflatoxin, and early-onset HCC in hepatitis B virus infection contribute to the burden of HCC in Latin America. Interventions to increase screening coverage, expand healthcare access, and implement continuing medical training are key challenges to be overcome. [ABSTRACT FROM AUTHOR]

Published
2020
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23. Interferon lambda and hepatitis C virus core protein polymorphisms associated with liver cancer

Author

Moreira, João Paulo, primary, Malta, Fernanda de Mello, additional, Diniz, Márcio Augusto, additional, Kikuchi, Luciana, additional, Chagas, Aline Lopes, additional, Lima, Livia de Souza Botelho, additional, Gomes-Gouvêa, Michele Soares, additional, de Castro, Vanessa Fusco Duarte, additional, Santana, Rubia Anita Ferraz, additional, Sumita, Nairo Massakazu, additional, Paranagua Vezozzo, Denise Cerqueira, additional, Carrilho, Flair José, additional, and Pinho, João Renato Rebello, additional

Published
2016
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24. Serum lipidomic profiling as a useful tool for screening potential biomarkers of hepatitis B-related hepatocellular carcinoma by ultraperformance liquid chromatography–mass spectrometry

Author

Passos-Castilho, Ana Maria, primary, Carvalho, Valdemir Melechco, additional, Cardozo, Karina Helena Morais, additional, Kikuchi, Luciana, additional, Chagas, Aline Lopes, additional, Gomes-Gouvêa, Michele Soares, additional, Malta, Fernanda, additional, de Seixas-Santos Nastri, Ana Catharina, additional, Pinho, João Renato Rebello, additional, Carrilho, Flair José, additional, and Granato, Celso Francisco Hernandes, additional

Published
2015
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25. Early variation of inflammatory indexes refines prognostic prediction in patients with hepatocellular carcinoma under systemic treatment.

Author

Da Fonseca, Leonardo G., Uratani, Lucas Fernando, Soares, Gabriella Fernandes, Do Amaral, Paulo Siqueira, De Souza Melo Alencar, Regiane Saraiva, Chagas, Aline Lopes, Alves, Venancio Avancini Ferreira, and Carrilho, Flair Jose

Subjects
PLATELET lymphocyte ratio, NEUTROPHIL lymphocyte ratio, PROGNOSIS, IMMUNOREGULATION, REGRESSION analysis
Abstract

Prognostic markers in advanced hepatocellular carcinoma (HCC) are relevant for clinical decisions. Variations in inflammatory indexes, such as neutrophil-to-lymphocyte ratio (NLR) or platelet-to-lymphocyte ratio (PLR), may correlate with outcomes. In the present study, it was aimed to assess the prognostic role of inflammation indexes in patients with HCC and the evolutionary behavior of these variables within the first month of treatment in a cohort of patients treated with sorafenib from 2009-2021. Subgroups were divided based on the median of each variable ('low' or 'high)'. Survival was estimated using the Kaplan-Meier method. Hazard Ratio (HR) with 95% confidence interval (CI) were estimated using Cox regression models. A total of 373 patients were included, most Child-Pugh-A (83.1%) and BCLC-C (74%). Child-Pugh-A (P=0.011), performance status 0 (P<0.001), no ascites (P<0.001) and NLR<2.6 (P<0.001) were independently associated with improved survival. Baseline PLR was not correlated with survival (P=0.137). Patients who maintained low NLR at baseline and at 1 month (reference subgroup) had improved survival (18.6 months, 95% CI:15.4-22.0) compared with the subgroup that maintained high NLR at baseline and at 1 month (4.2 months, 95% CI:3.6-5.9), with HR: 3.80 (95% CI: 2.89-4.96). The subgroup with low NLR at baseline and high NLR at 1 month had a worse prognosis compared with the reference group (HR:1.4, 95% CI: 1.1-2.0), whereas the subgroup with high NLR at baseline and low at 1 month had similar outcome (HR:1.2, 95% CI: 0.8-1.6). It was concluded that evolutionary variation of NLR has a prognostic role in HCC patients under systemic therapy. This finding suggested that systemic inflammation and early modulation of the immune environment during treatment may correlate with outcomes. [ABSTRACT FROM AUTHOR]

Published
2023
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26. Use of Initial Modified RECIST Tumor Response Evaluation Criteria for Predicting Survival in Patients with Hepatocellular Carcinoma Undergoing Transarterial Chemoembolization with Drug-Eluting Beads

Author

Queiroz, Natália Sousa Freitas, primary, Kikuchi, Luciana, additional, Bezerra, Regis Otaviano Franca, additional, Alencar, Regiane S. S. M., additional, Chagas, Aline Lopes, additional, Tani, Cláudia Megumi, additional, Diniz, Márcio Augusto, additional, Santos, Aline Cristine Barbosa, additional, Moreira, Airton Mota, additional, Rocha, Manoel de Souza, additional, D’Albuquerque, Luiz Augusto Carneiro, additional, Carnevale, Francisco César, additional, and Carrilho, Flair José, additional

Published
2015
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28. A multicenter international study of sorafenib treatment in patients with hepatocellular carcinoma and chronic kidney disease undergoing hemodialysis

Author

Diaz-Gonzalez, Alvaro, Sanduzzi-Zamparelli, Marco, Gomes Da Fonseca, Leonardo, Di Costanzo, Giovan Giuseppe, Alves, Rogerio, Iavarone, Massimo, Leal, Cassia Regina G., Sacco, Rodolfo, Matilla, Ana M., Hernandez Guerra, Manuel, Aballay Soteras, Gabriel Alejandro, Marcus, Worns, Pinter, Matthias, Varela, Maria, Ladekarl, Morten, Chagas, Aline Lopes, Minguez, Beatriz, Arenas Ruiz-Tapiador, Juan Ignacio, Granito, Alessandro, Sanchez, Yolanda, Rojas, Angela, Rodriguez Lope, Carlos, Mario Alvares-da-Silva, Pascual, Sonia, Rimassa, Lorenza, Luis Lledo, Jose, Huertas, Carlos, Sangro, Bruno, Giannini, Edoardo Giovanni, Delgado, Manuel, Vergara Gomez, Mercedes, Perello, Christie, Lue, Alberto, Sala, Margarita, Gallego Moya, Adolfo, Coll, Susana, Hernaez Alsina, Tania, Pinero, Federico, Pereira, Gustavo, Callado Franca, Alex Vianey, Marin, Juan, Margarita Anders, Maria, Mello, Vivianne, Del Mar Lozano, Maria, Nault, Jean Charles, Maria Menendez, Jose, Garcia Juarez, Ignacio, Bruix, Jordi, Reig, Maria, Diaz-Gonzalez, A, Sanduzzi-Zamparelli, M, da Fonseca, L, Costanzo, GG, Alves, R, Iavarone, M, Leal, CRG, Sacco, R, Matilla, AM, Guerra, M, Soteras, GA, Marcus, W, Pinter, M, Varela, M, Ladekarl, M, Chagas, AL, Minguez, B, Ruiz-Tapiador, JI, Granito, A, Sanchez, Y, Rojas, A, De Lope, C, Alvares-Da-Silva, MR, Pascual, S, Rimassa, L, Lledo, J, Huertas, C, Sangro, B, Giannini, EG, Delgado, M, Gomez, MV, Perello, C, Lue, A, Sala, M, Moya, AG, Coll, S, Alsina, TH, Pinero, F, Pereira, G, Franca, AV, Marin, J, Anders, MM, Mello, V, Lozano, MD, Nault, JC, Menendez, JM, Juarez, IG, Bruix, J, and Reig, M

Subjects
Hepatocellular carcinoma, sorafenib, sorafenib, hemodialysis

29. FRI134 - Hepatocellular carcinoma in patients with autoimmune hepatitis: prevalence and risk factors.

Author

Vaz, Nayana Fonseca, Margon, Julia Fadini, Moutinho, Bruna Damasio, Braga, Michele Harriz, Tani, Claudia Megumi, de Souza Melo Alencar, Regiane Saraiva, da Cunha Saud, Lisa Rodrigues, Paranaguá Vezozzo, Denise Cerqueira, Deguti, Marta, Horvat, Natally, Rachid Cançado, Eduardo Luiz, Carrilho, Flair Jose, Chagas, Aline Lopes, and Terrabuio, Débora

Subjects
*HEPATOCELLULAR carcinoma, *CHRONIC active hepatitis, *LIVER diseases
Published
2020
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30. Treatment Outcomes in Patients with Advanced Fibrolamellar Hepatocellular Carcinoma Under Systemic Treatment: Analysis of Clinical Characteristics, Management, and Radiomics.

Author

Da Fonseca LG, Yamamoto VJ, Trinconi Cunha M, Torre GS, Araujo RLC, Fonseca GM, Chen ATC, Chagas AL, Herman P, Alves VAF, and Carrilho FJ

Abstract

Purpose: Fibrolamellar hepatocellular carcinoma (FLHCC) is a rare primary liver malignancy often diagnosed at advanced stages. While there are limited data on the efficacy of specific agents, we aim to report outcomes of patients treated with systemic therapies and explore prognostic factors., Patients and Methods: Medical records of patients treated between 2010 and 2022 were reviewed. Treatments were defined after multidisciplinary assessment. Descriptive statistics were used for baseline demographics. Time-to-event outcomes were estimated using the Kaplan-Meier method, compared by log-rank and adjusted by a regression model. Radiomic features (including size, shape, and texture) of the primary lesion were extracted and dimensionality reduced. An unsupervised Gaussian Mixture Model (GMM) clustering was performed, and survival was compared between clusters., Results: We identified 23 patients: 12 males, with a median age of 23.6 years. At diagnosis, 82.6% had metastases, most frequently to the lungs (39.1%), lymph nodes (39.1%), and peritoneum (21.7%). Patients received a median of three lines (1-8) of treatment, including different regimens. Sorafenib (39.1%), capecitabine (30.4%), and capecitabine/interferon (13%) were the most used first-line regimens. The median time-to-failure was 3.8 months (95% CI: 3.2-8.7). Capecitabine + interferon (42.1%) and platinum combinations (39.1%) were the most used second-line regimens, with a time-to-failure of 3.5 months (95% CI: 1.5-11.6). Median overall survival was 26.7 months (95% CI: 15.1-40.4). A high baseline neutrophil-to-lymphocyte ratio (NLR) was associated with worse survival (p=0.02). Radiomic features identified three clusters, with one cluster (n=6) having better survival (40.4 vs 22.6 months, p=0.039). Tumor sphericity in the arterial phase was the most relevant characteristic associated with a better prognosis (accuracy=0.93)., Conclusion: FLHCC has unique features compared to conventional HCC, including young onset, gender balance, and absence of hepatopathy. Systemic therapies can provide encouraging survival, but lack of uniformity precludes defining a preferable regimen. Radiomics and NLR were suggested to correlate with prognosis and warrant further validation., Competing Interests: Da Fonseca LG received fees from Bayer, BMS, AstraZeneca, and Roche. The authors report no other conflicts of interest in this work., (© 2023 Da Fonseca et al.)

Published
2023
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31. BRAZILIAN SOCIETY OF HEPATOLOGY UPDATED RECOMMENDATIONS FOR SYSTEMIC TREATMENT OF HEPATOCELLULAR CARCINOMA.

Author

Chagas AL, Leal CRG, Mello VB, Barros FMDR, Bittencourt PL, Mattos AA, Aroucha D, Fonseca LGD, Silva JRL, Dottori MF, Teixeira R, Mendes LSC, Rezende REF, Filgueira NA, Coutinho AK, Araújo Neto JM, Coelho HSM, Pessoa MG, Cheinquer H, Parise ER, França A, Álvares-DA-Silva MR, Carrilho FJ, Coral GP, Pinto PTA, Pereira LMMB, Paraná R, Alves RCP, and Brandão-Mello CE

Subjects
Humans, Brazil, Societies, Medical, Carcinoma, Hepatocellular diagnosis, Liver Neoplasms drug therapy, Liver Neoplasms diagnosis, Gastroenterology
Abstract

Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related mortality worldwide. The Brazilian Society of Hepatology (SBH) published in 2020 the updated recommendations for the diagnosis and treatment of HCC. Since then, new data have emerged in the literature, including new drugs approved for the systemic treatment of HCC that were not available at the time. The SBH board conducted an online single-topic meeting to discuss and review the recommendations on the systemic treatment of HCC. The invited experts were asked to conduct a systematic review of the literature on each topic related to systemic treatment and to present the summary data and recommendations during the meeting. All panelists gathered together for discussion of the topics and elaboration of the updated recommendations. The present document is the final version of the reviewed manuscript containing the recommendations of SBH and its aim is to assist healthcare professionals, policy-makers, and planners in Brazil and Latin America with systemic treatment decision-making of patients with HCC.

Published
2023
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32. Feasibility of SBRT for hepatocellular carcinoma in Brazil - a prospective pilot study.

Author

Chen ATC, Payão F, Chagas AL, De Souza Melo Alencar RS, Tani CM, da Conceição Vasconcelos KGM, de Souza Rocha M, de Andrade Carvalho H, Hoff PMG, and Carrilho FJ

Abstract

Background: The aim of the study was to evaluate the feasibility and safety of stereotactic body radiotherapy (SBRT) for the treatment of hepatocellular carcinoma in Brazil. SBRT is an evolving treatment in HCC patients not candidates to other local therapies. Its adoption in clinical practice has been heterogeneous, with lack of data on its generalizability in the Brazilian population., Materials and Methods: We conducted a prospective pilot study involving HCC patients after failure or ineligibility for transarterial chemoembolization. Patients received SBRT 30 to 50 Gy in 5 fractions using an isotoxic prescription approach. This study is registered at clinicaltrials.gov NCT02221778., Results: From Nov 2014 through Aug 2019, 26 patients received SBRT with 40 Gy median dose. Underlying liver disease was hepatitis C, hepatitis B and alcohol-related in, respectively, 50%, 23% and 19% of patients. Median lesion size was 3.8 cm (range, 1.5-10 cm), and 46% had multiple lesions. Thirty-two percent had tumor vascular thrombosis; median pretreatment alpha-fetoprotein (AFP) was 171.7 ng/mL (range, 4.2-5,494 ng/mL). 1y-local progression-free survival (PFS) was 86% (95% CI: 61% to 95%), with higher local control in doses ≥ 45Gy (p = 0.037; HR = 0.12). 1y-liver PFS, distant PFS and OS were, respectively, 52%, 77% and 79%. Objective response was seen in 89% of patients, with 3 months post-SBRT median AFP of 12 ng/mL (2.4-637 ng/mL). There were no grade 3 or 4 clinical toxicities. Grade 3 or 4 laboratory toxicities occurred in 27% of patients., Conclusion: SBRT is feasible and safe in patients unresponsive or ineligible for TACE in Brazil. Our study suggests doses ≥ 45 Gy yields better local control., Competing Interests: Conflict of interest None declared., (© 2021 Greater Poland Cancer Centre.)

Published
2021
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33. Multimodality Screening of Hepatic Nodules in Patients With Congenital Heart Disease After Fontan Procedure: Role of Ultrasound, ARFI Elastography, CT, and MRI.

Author

Horvat N, Rocha MS, Chagas AL, Oliveira BC, Pacheco MP, Binotto MA, Ikari NM, Paranaguá-Vezozzo DC, Leao-Filho HM, Vicentini JRT, Moreira da Silva Filho MR, Jatene MB, Carrilho FJ, and Cerri GG

Subjects
Adult, Cross-Sectional Studies, Elasticity Imaging Techniques, Female, Heart Defects, Congenital complications, Heart Defects, Congenital diagnostic imaging, Humans, Liver Diseases complications, Male, Multimodal Imaging, Predictive Value of Tests, Young Adult, Fontan Procedure, Heart Defects, Congenital surgery, Liver Diseases diagnostic imaging, Magnetic Resonance Imaging, Tomography, X-Ray Computed, Ultrasonography
Abstract

Objective: Currently, there is no consensus in the literature regarding the screening of hepatic nodules in patients who have undergone the Fontan procedure. The objectives of this study are to evaluate in this population the frequency of hepatic nodules at ultrasound (US), CT, and MRI; to measure liver stiffness using acoustic radiation force impulse (ARFI) elastography; and to investigate predictive factors for hepatic nodules., Subjects and Methods: In this cross-sectional study, 49 patients who underwent the Fontan procedure were prospectively recruited from August 2014 through June 2016. These patients underwent clinical evaluation for hepatic disorders, ARFI elastography, US, CT, and MRI., Results: Most of the patients had no symptoms, and hepatic nodules were detected in three of 49 (6.1%) patients at US, 14 of 44 (31.8%) patients at CT, and 19 of 48 (39.6%) patients at MRI. Liver stiffness at ARFI elastography was significantly higher in patients with hepatic nodules than in patients without such nodules (2.64 ± 0.81 m/s vs 1.94 ± 0.49 m/s; p = 0.002) and was a significant predictor of hepatic nodule (AUC, 0.767; p = 0.002). No clinical or laboratory data had any significant correlation with the existence of hepatic nodules, including time since Fontan procedure., Conclusion: In our study, more than one-third of patients had hepatic nodules at CT or MRI, but US did not detect most hepatic nodules. Liver stiffness at ARFI elastography was significantly higher in patients with hepatic nodules, and it may help guiding which patient should be further imaged with CT or MRI.

Published
2018
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34. Hepatocellular Carcinoma Related to Schistosoma mansoni Infection: Case Series and Literature Review.

Author

Toda KS, Kikuchi L, Chagas AL, Tanigawa RY, Paranaguá-Vezozzo DC, Pfiffer T, Rocha Mde S, Alves VA, and Carrilho FJ

Abstract

Background and Aims: Schistosomiasis is a major chronic disease of humans in endemic regions, and infected individuals may develop a spectrum of pathology, including hepatic fibrosis, hepatosplenomegaly, and portal hypertension. Hepatocellular carcinoma (HCC) is considered the fifth most common cancer in the world, and there is limited and controversial evidence suggesting that Schistosoma mansoni infection may be a possible risk factor for HCC. The aim of this study was to report a case series of patients with HCC and S. mansoni infection and to conduct a literature review on the topic., Methods: From January 2002 to January 2015, an institutional database was screened retrospectively to identify patients with HCC and S. mansoni infection at a single center in the Department of Gastroenterology of University of São Paulo School of Medicine and Hospital das Clínicas, Brazil., Results: Seven cases were included. The mean age of patients was 62.1±10.3 years; six (85.7%) were male and one (14.3%) was female. All cases had positive epidemiology, coming from endemic areas of S. mansoni infection in Brazil, and four (57.1%) had previous complications (upper gastrointestinal bleeding) related to portal hypertension or surgery intervention (splenectomy) performed more than 10 years before the HCC diagnosis. Nontumoral portal vein thrombosis was identified in five (71.4%) patients. All patients had negative serology for HCV, and four (57.1%) had positivity of HBVcore antibodies without evidence of viral replication. According to BCLC staging, one (14.3%) patient was BCLC A and received TACE instead of RFA because HCC size was >30 mm; three (42.8%) BCLC B patients received sorafenib instead of local regional treatment due to the presence of nontumoral TPV. During follow-up, all patients developed tumoral progression and died., Conclusions: It remains unclear if S. mansoni infection alone has carcinogenic potential. The available literature indicates that S. Mansoni, in the presence of HBV and HCV infections, likely acts as a cofactor for the hepatic lesion and potentiates injury.

Published
2015
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