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3. A meta-analysis of echocardiographic measurements of the left heart for the development of normative reference ranges in a large international cohort: the EchoNoRMAL study

Author

Doughty, R. N., Gardin, J. M., Hobbs, F. D. R., McMurray, J. J. V., Nagueh, S. F., Poppe, K. K., Senior, R., Thomas, L., Whalley, G. A., Aune, E., Brown, A., Badano, L. P., Cameron, V., Chadha, D. S., Chahal, N., Chien, K. L., Daimon, M., Dalen, H., Detrano, R., Akif Duzenli, M., Ezekowitz, J., de Simone, G., Di Pasquale, P., Fukuda, S., Gill, P. S., Grossman, E., Hobbs, F. D. R., Kim, H. –K., Kuznetsova, T., Leung, N. K. W., Linhart, A., McDonagh, T. A., McGrady, M., McMurray, J. J. V., Mill, J. G., Mogelvang, R., Muiesan, M. L., Ng, A. C. T., Ojji, D., Otterstad, J. E., Petrovic, D. J., Poppe, K. K., Prendergast, B., Rietzschel, E., Schirmer, H., Schvartzman, P., Senior, R., Simova, I., Sliwa, K., Stewart, S., Squire, I. B., Takeuchi, M., Thomas, L., Whalley, G. A., Altman, D., Perera, R., Poppe, K. K., Triggs, C. M., Au Yeung, H., Beans Picón, G. A., Poppe, K. K., and Whalley, G. A.

Published
2014
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5. Fully Automatic Myocardial Segmentation of Contrast Echocardiography Sequence Using Random Forests Guided by Shape Model

Author

Li, Y, Ho, CP, Toulemonde, M, Chahal, N, Senior, R, Tang, MX, and Engineering & Physical Science Research Council (EPSRC)

Subjects
FOS: Computer and information sciences, Technology, LEFT-VENTRICLE, IMAGES, Computer Vision and Pattern Recognition (cs.CV), ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION, Computer Science - Computer Vision and Pattern Recognition, convolutional neural network, 09 Engineering, Engineering, statistical shape model, Imaging Science & Photographic Technology, Engineering, Biomedical, 08 Information And Computing Sciences, Science & Technology, Radiology, Nuclear Medicine & Medical Imaging, BOUNDARY DETECTION, Engineering, Electrical & Electronic, LOCALIZATION, contrast echocardiography, Nuclear Medicine & Medical Imaging, Computer Science, Computer Science, Interdisciplinary Applications, Life Sciences & Biomedicine, myocardial segmentation, Random forest
Abstract

Myocardial contrast echocardiography (MCE) is an imaging technique that assesses left ventricle function and myocardial perfusion for the detection of coronary artery diseases. Automatic MCE perfusion quantification is challenging and requires accurate segmentation of the myocardium from noisy and time-varying images. Random forests (RF) have been successfully applied to many medical image segmentation tasks. However, the pixel-wise RF classifier ignores contextual relationships between label outputs of individual pixels. RF which only utilizes local appearance features is also susceptible to data suffering from large intensity variations. In this paper, we demonstrate how to overcome the above limitations of classic RF by presenting a fully automatic segmentation pipeline for myocardial segmentation in full-cycle 2D MCE data. Specifically, a statistical shape model is used to provide shape prior information that guide the RF segmentation in two ways. First, a novel shape model (SM) feature is incorporated into the RF framework to generate a more accurate RF probability map. Second, the shape model is fitted to the RF probability map to refine and constrain the final segmentation to plausible myocardial shapes. We further improve the performance by introducing a bounding box detection algorithm as a preprocessing step in the segmentation pipeline. Our approach on 2D image is further extended to 2D+t sequence which ensures temporal consistency in the resultant sequence segmentations. When evaluated on clinical MCE data, our proposed method achieves notable improvement in segmentation accuracy and outperforms other state-of-the-art methods including the classic RF and its variants, active shape model and image registration., 11 pages, 9 figures, published in TMI

Published
2018

6. A meta-analysis of echocardiographic measurements of the left heart for the development of normative reference ranges in a large international cohort: the EchoNoRMAL study

Author

Anderson T., Dyck J., Ezekowitz J. A., Chirinos J. A., De Buyzere M. L., Gillebert T. C., Rietzschel E., Segers P., Van Daele C. M., Doughty R. N., Poppe K. K., Walsh H. A., Whalley G. A., Chen P. C., Chien K. L., Lin H. J., Su, T. C., Mogelvang R., Jensen J. S., Chadha D. S., Goel K., Misra A., Detrano R., Cameron V., Richards A. M., Troughton R., Di Pasquale P., Paterna S., Duzenli M. A., Hobbs F. D. R., Davies M. K., Davis R. C., Roalfe A., Calvert M., Freemantle N., Gill, P. S., Lip G. Y. H., Kuznetsova T., Staessen J. A., Dargie H. J., Ford I., McDonagh T. A., McMurray J. J. V., Grossman E., Galasko G., Lahiri A., Senior R., Blauwet L., Sliwa K., Stewart S., Brown A., Carrington M., Krum H., McGrady M., Zeitz C., Dalen H., Hansen H. E. M., Støylen A., Thorstensen A., Daimon M., Watanabe H., Yoshikawa J., Fukuda S., Kim H. K., Leung N. K. W., Linhart A., Chahal N., Chambers J. C., Kooner J., Davies J., Loke I., Ng, L., Squire I. B., Aune E., Otterstad J. E., Leung D. Y., Ng A. C. T., Ojji D., Arnold L., Coffey S., D'Arcy J., Hammond C., Mabbett C., Lima C., Loudon M., Pinheiro N., Prendergast B., Reynolds R., Badano L. P., Muraru D., Peluso D., Dal Bianco L., Petrovic D. J., Petrovic J., Schvartzman P., Fuchs F. D., Katova T., Simova I., Kaku K., Takeuchi M., Boyd A., Thomas L., Chia E. M., Schirmer H., Angelo L. C., Pereira A. C., Krieger J. E., Mill J. G., Rodrigues S. L., Muiesan M. L., Paini A., Rosei E. A., Salvetti M., Gardin J. M., Nagueh S. F., Altman D., Perera R., Triggs C. M., Au Yeung H., Beans Picon G. A., IZZO, RAFFAELE, DE LUCA, NICOLA, TRIMARCO, BRUNO, DE SIMONE, GIOVANNI, Anderson, T., Dyck, J., Ezekowitz, J. A., Chirinos, J. A., De Buyzere, M. L., Gillebert, T. C., Rietzschel, E., Segers, P., Van Daele, C. M., Doughty, R. N., Poppe, K. K., Walsh, H. A., Whalley, G. A., Izzo, Raffaele, DE LUCA, Nicola, Trimarco, Bruno, DE SIMONE, Giovanni, Chen, P. C., Chien, K. L., Lin, H. J., Su, T. C., Mogelvang, R., Jensen, J. S., Chadha, D. S., Goel, K., Misra, A., Detrano, R., Cameron, V., Richards, A. M., Troughton, R., Di Pasquale, P., Paterna, S., Duzenli, M. A., Hobbs, F. D. R., Davies, M. K., Davis, R. C., Roalfe, A., Calvert, M., Freemantle, N., Gill, P. S., Lip, G. Y. H., Kuznetsova, T., Staessen, J. A., Dargie, H. J., Ford, I., Mcdonagh, T. A., Mcmurray, J. J. V., Grossman, E., Galasko, G., Lahiri, A., Senior, R., Blauwet, L., Sliwa, K., Stewart, S., Brown, A., Carrington, M., Krum, H., Mcgrady, M., Zeitz, C., Dalen, H., Hansen, H. E. M., Støylen, A., Thorstensen, A., Daimon, M., Watanabe, H., Yoshikawa, J., Fukuda, S., Kim, H. K., Leung, N. K. W., Linhart, A., Chahal, N., Chambers, J. C., Kooner, J., Davies, J., Loke, I., Ng, L., Squire, I. B., Aune, E., Otterstad, J. E., Leung, D. Y., Ng, A. C. T., Ojji, D., Arnold, L., Coffey, S., D'Arcy, J., Hammond, C., Mabbett, C., Lima, C., Loudon, M., Pinheiro, N., Prendergast, B., Reynolds, R., Badano, L. P., Muraru, D., Peluso, D., Dal Bianco, L., Petrovic, D. J., Petrovic, J., Schvartzman, P., Fuchs, F. D., Katova, T., Simova, I., Kaku, K., Takeuchi, M., Boyd, A., Thomas, L., Chia, E. M., Schirmer, H., Angelo, L. C., Pereira, A. C., Krieger, J. E., Mill, J. G., Rodrigues, S. L., Muiesan, M. L., Paini, A., Rosei, E. A., Salvetti, M., Gardin, J. M., Nagueh, S. F., Altman, D., Perera, R., Triggs, C. M., Au Yeung, H., Beans Picon, G. A., and Badano, L

Subjects
Male, Pediatrics, International Cooperation, Left, Ethnic Group, Sex Factor, Ventricular Function, Left, Heart Ventricle, Cohort Studies, Echocardiography, Meta-analysis, Reference ranges, Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Atrial Function, Left, Ethnic Groups, Female, Heart Atria, Heart Ventricles, Humans, Middle Aged, Reference Standards, Sex Factors, Young Adult, Cardiology and Cardiovascular Medicine, Radiology, Nuclear Medicine and Imaging, Nuclear Medicine and Imaging, 80 and over, Ethnicity, Ventricular Function, Age Factor, Young adult, education.field_of_study, General Medicine, Atrial Function, Parametric Regression Method, Cohort, Cardiology, Radiology, Human, Cohort study, medicine.medical_specialty, Population, Internal medicine, medicine, Meta-analysi, Radiology, Nuclear Medicine and imaging, education, business.industry, Reference range, MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE, Quantile regression, Reference Standard, Normative, Cohort Studie, business
Abstract

Aim: To develop age-, sex-, and ethnic-Appropriate normative reference ranges for standard echocardiographic measurements of the left heart by combining echocardiographic measurements obtained from adult volunteers without clinical cardiovascular disease or significant cardiovascular risk factors, from multiple studies around the world.Methods and results: The Echocardiographic Normal Ranges Meta-Analysis of the Left heart (EchoNoRMAL) collaboration was established and population-based data sets of echocardiographic measurements combined to perform an individual person data meta-Analysis. Data from 43 studies were received, representing 51 222 subjects, of which 22 404 adults aged 18-80 years were without clinical cardiovascular or renal disease, hypertension or diabetes. Quantile regression or an appropriate parametric regression method will be used to derive reference values at the 5th and 95th centile of each measurement against age. Conclusion: This unique data set represents a large, multi-ethnic cohort of subjects resident in a wide range of countries. The resultant reference ranges will have wide applicability for normative data based on age, sex, and ethnicity. © The Author 2013.

Published
2013

7. High frame rate contrast echocardiography –in human demonstration

Author

Toulemonde, MEG, Corbett, R, Papadopoulou, V, Chahal, N, Li, Y, Leow, CH, Cosgrove, D, Eckersley, RJ, Duncan, N, Senior, R, Tang, MX, Imperial College Healthcare NHS Trust- BRC Funding, and Engineering & Physical Science Research Council (EPSRC)

Subjects
Cardiovascular System & Hematology, 1103 Clinical Sciences, 1102 Cardiovascular Medicine And Haematology
Published
2017

8. Reproducible computer assisted quantification of myocardial perfusion with contrast enhanced ultrasound

Author

Li, Y, Chahal, N, Senior, R, Tang, M, and Engineering & Physical Science Research Council (EPSRC)

Subjects
Technology, Science & Technology, Radiology, Nuclear Medicine & Medical Imaging, Computer-assisted quantification, 1103 Clinical Sciences, Acoustics, Myocardial contrast echocardiography, Coronary artery disease, ANGIOGRAPHY, Reproducibility, BLOOD-FLOW RESERVE, Myocardial perfusion, VARIABILITY, STRESS ECHOCARDIOGRAPHY, TOMOGRAPHY, CORONARY-ARTERY-DISEASE, INFARCTION, Life Sciences & Biomedicine
Abstract

Myocardial perfusion can be quantified by myocardial contrast echocardiography (MCE) and is used for the diagnosis of coronary artery disease (CAD). However, existing MCE quantification software is highly operator dependent and has poor reproducibility and ease of usage. The aim of this study was to develop robust and easy-to-use software that can perform MCE quantification accurately, reproducibly and rapidly. The developed software has the following features: (i) semi-automatic segmentation of the myocardium; (ii) automatic rejection of MCE data with poor image quality; (iii) automatic computation of perfusion parameters such as myocardial blood flow (MBF). MCE sequences of 18 individuals (9 normal, 9 with CAD) undergoing vasodilator stress with dipyridamole were analysed quantitatively using the software. When evaluated against coronary angiography, the software achieved a sensitivity of 71% and a specificity of 91% for hyperemic MBF. With the automatic rejection algorithm, the sensitivity and specificity further improved to 77% and 94%, respectively. For MBF reproducibility, the percentage agreement is 85% (κ = 0.65) for inter-observer variability and 88% (κ = 0.72) for intra-observer variability. The intra-class correlation coefficients are 0.94 (inter-observer) and 0.96 (intra-observer). The time taken to analyse one MCE sequence using the software is about 3 min on a PC. The software has exhibited good diagnostic performance and reproducibility for CAD detection and is rapid and user-friendly.

Published
2017

12. Ethnic-specific normative reference values for echocardiographic la and LV size, LV mass, and systolic function: The EchoNoRMAL study

Author

Poppe, K. K., Doughty, R. N., Gardin, J. M., Nagueh, S. F., Whalley, G. A., Cameron, V., Chadha, D. S., Chien, K. L., Detrano, R., Akif Duzenli, M., Ezekowitz, J., Di Pasquale, P., Mogelvang, R., Altman, D. G., Perera, R., Triggs, C. M., Au Yeung, H., Beans Picon, G. A., Anderson, T., Dyck, J., Ezekowitz, J. A., Chirinos, J. A., De Buyzere, M. L., Gillebert, T. C., Rietzschel, E., Segers, P., Van daele, C. M., Walsh, H. A., Izzo, R., De Luca, N., Trimarco, B., De Simone, G., Goel, K., Misra, A., Chen, P. C., Lin, H. J., T. C., Su, Richards, A. M., Troughton, R., Skov Jensen, J., Paterna, S., Hobbs, F. D. R., Davies, M. K., Davis, R. C., Roalfe, A., Calvert, M., Freemantle, N., Gill, P. S., Lip, G. Y. H., Kuznetsova, T., Staessen, J. A., Dargie, H. J., Ford, I., Mcdonagh, T. A., Mcmurray, J. J. V., Grossman, E., Galasko, G., Lahiri, A., Senior, R., Brown, A., Carrington, M., Krum, H., Mcgrady, M., Stewart, S., Zeitz, C., Blauwet, L., Sliwa, K., Dalen, H., Moelmen Hansen, H. E., Stoylen, A., Thorstensen, A., Daimon, M., Watanabe, H., Yoshikawa, J., Fukuda, S., Kim, H. K., Leung, N. K. W., Linhart, A., Chahal, N., Chambers, J. C., Kooner, J., Davies, J., Loke, I., Ng, L., Squire, I. B., Aune, E., Otterstad, J. E., Leung, D. Y., A. C. T., Ng, Ojji, D., Arnold, L., Coffey, S., D'Arcy, J., Hammond, C., Mabbett, C., Lima, C., Loudon, M., Pinheiro, N., Prendergast, B., Reynolds, R., Badano, L. P., Muraru, D., Peluso, D., DAL BIANCO, Laura, Petrovic, D. J., Petrovic, J., Schvartzman, P., Fuchs, F. D., Katova, T., Simova, I., Kaku, K., Takeuchi, M., Boyd, A., Chia, E. M., Thomas, L., Schirmer, H., Angelo, L. C., Pereira, A. C., Krieger, J. E., Mill, J. G., Rodrigues, S. L., Muiesan, Maria Lorenza, Paini, Anna, AGABITI ROSEI, Enrico, and Salvetti, Massimo

Subjects
Nuclear Medicine and Imaging, echocardiography, ethnic appropriate, reference ranges, Cardiology and Cardiovascular Medicine, Radiology, Nuclear Medicine and Imaging, Radiology
Published
2015

18. Ethnic-Specific Normative Reference Values for Echocardiographic LA and LV Size, LV Mass, and Systolic Function

Author

Poppe, K.K., primary, Doughty, R.N., additional, Gardin, J.M., additional, Hobbs, F.D.R., additional, McMurray, J.J.V., additional, Nagueh, S.F., additional, Senior, R., additional, Thomas, L., additional, Whalley, G.A., additional, Aune, E., additional, Brown, A., additional, Badano, L.P., additional, Cameron, V., additional, Chadha, D.S., additional, Chahal, N., additional, Chien, K.L., additional, Daimon, M., additional, Dalen, H., additional, Detrano, R., additional, Akif Duzenli, M., additional, Ezekowitz, J., additional, de Simone, G., additional, Di Pasquale, P., additional, Fukuda, S., additional, Gill, P.S., additional, Grossman, E., additional, Kim, H.-K., additional, Kuznetsova, T., additional, Leung, N.K.W., additional, Linhart, A., additional, McDonagh, T.A., additional, McGrady, M., additional, Mill, J.G., additional, Mogelvang, R., additional, Muiesan, M.L., additional, Ng, A.C.T., additional, Ojji, D., additional, Otterstad, J.E., additional, Petrovic, D.J., additional, Poppe, K.K., additional, Prendergast, B., additional, Rietzschel, E., additional, Schirmer, H., additional, Schvartzman, P., additional, Simova, I., additional, Sliwa, K., additional, Stewart, S., additional, Squire, I.B., additional, Takeuchi, M., additional, Altman, D.G., additional, Perera, R., additional, Triggs, C.M., additional, Au Yeung, H., additional, Beans Picón, G.A., additional, Anderson, T., additional, Dyck, J., additional, Ezekowitz, J.A., additional, Chirinos, J.A., additional, De Buyzere, M.L., additional, Gillebert, T.C., additional, Segers, P., additional, Van daele, C.M., additional, Walsh, H.A., additional, Izzo, R., additional, De Luca, N., additional, Trimarco, B., additional, Goel, K., additional, Misra, A., additional, Chen, P.-C., additional, Lin, H.-J., additional, Su, T.-C., additional, Richards, A.M., additional, Troughton, R., additional, Skov Jensen, J., additional, Paterna, S., additional, Davies, M.K., additional, Davis, R.C., additional, Roalfe, A., additional, Calvert, M., additional, Freemantle, N., additional, Lip, G.Y.H., additional, Staessen, J.A., additional, Dargie, H.J., additional, Ford, I., additional, Galasko, G., additional, Lahiri, A., additional, Carrington, M., additional, Krum, H., additional, Zeitz, C., additional, Blauwet, L., additional, Moelmen Hansen, H.E., additional, Støylen, A., additional, Thorstensen, A., additional, Watanabe, H., additional, Yoshikawa, J., additional, Chambers, J.C., additional, Kooner, J., additional, Davies, J., additional, Loke, I., additional, Ng, L., additional, Leung, D.Y., additional, Arnold, L., additional, Coffey, S., additional, d'Arcy, J., additional, Hammond, C., additional, Mabbett, C., additional, Lima, C., additional, Loudon, M., additional, Pinheiro, N., additional, Reynolds, R., additional, Muraru, D., additional, Peluso, D., additional, Dal Bianco, L., additional, Petrovic, J., additional, Fuchs, F.D., additional, Katova, T., additional, Kaku, K., additional, Boyd, A., additional, Chia, E.M., additional, Angelo, L.C., additional, Pereira, A.C., additional, Krieger, J.E., additional, Rodrigues, S.L., additional, Paini, A., additional, Agabiti Rosei, E., additional, and Salvetti, M., additional

Published
2015
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27. Do traditional risk stratification models for cerebrovascular events apply in irradiated head and neck cancer patients?

Author

Gujral, D. M., Shah, B. N., Chahal, N. S., Bhattacharyya, S., Senior, R., Harrington, K. J., and Nutting, C. M.

Subjects
CEREBROVASCULAR disease, CANCER patients, HEAD & neck cancer, RADIOTHERAPY, ELECTROTHERAPEUTICS
Abstract

Background: Primary radical radiotherapy (RT) for head and neck cancer (HNC) often results in significant radiation dose to the carotid arteries. Aim: We assessed whether HNC patients are at increased risk of a cerebrovascular event primarily due to RT or other risk factors for atherosclerosis by (i) risk-stratifying patients according to validated QRISK-2 and QSTROKE scores and (ii) comparing the prevalence of carotid artery stenosis (CAS) in irradiated and unirradiated carotid arteries. Design: HNC patients treated with an RT dose >50 Gy to one side of the neck ≥2 years previously were included. Methods: QRISK-2 (2014) and Q-STROKE (2014) scores were calculated. We compared the prevalence of CAS in segments of the common carotid artery on the irradiated and unirradiated sides of the neck. Results: Fifty patients (median age of 58 years (interquartile range (IQR) 50-62)) were included. The median QRISK-2 score was 10% (IQR 4.4-15%) and the median QSTROKE score was 3.4% (IQR 1.4-5.3%). For both scores, no patient was classified as high risk. Thirty-eight patients (76%) had CAS in one or both arteries. There was a significant difference in the number of irradiated arteries with stenosis (N=37) compared with unirradiated arteries (N=16) (P<0.0001). There were more plaques on the irradiated artery compared with the unirradiated side - 64/87 (73.6%) versus 23/87 (26.4%), respectively (P<0.001). Conclusions: Traditional vascular risk factors do not play a role in radiation-induced carotid atherosclerosis. Clinicians should be aware that traditional risk prediction models may under-estimate stroke risk in these patients. [ABSTRACT FROM AUTHOR]

Published
2016
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36. Poster session I * Thursday 9 December 2010, 08:30-12:30

Author

Kuznetsov, V. A., primary, Kozhurina, A. O., additional, Plusnin, A. V., additional, Szulik, M., additional, Sredniawa, B., additional, Streb, W., additional, Lenarczyk, R., additional, Stabryla-Deska, J., additional, Sedkowska, A., additional, Kowalski, O., additional, Kalarus, Z., additional, Kukulski, T., additional, Katova, T. M., additional, Nesheva, A., additional, Simova, I., additional, Hristova, K., additional, Kostova, V., additional, Boiadjiev, L., additional, Dimitrov, N., additional, Papamichalis Michalis, M. P., additional, Sitafidis George, S. G., additional, Dimopoulos Basilios, B. D., additional, Kelepesis Glafkos, G. K., additional, Economou Dimitrios, D. E., additional, Skoularigis John, J. S., additional, Triposkiadis Filippos, F. T., additional, Attenhofer Jost, C. H., additional, Pfyffer, M., additional, Naegeli, B., additional, Levis, P., additional, Faeh-Gunz, A., additional, Brunner-Larocca, H. P., additional, Velasco Del Castillo, M. S., additional, Cacicedo, A., additional, Onaindia, J. J., additional, Gonzalez Ruiz, J., additional, Subinas, A., additional, Alarcon, J. A., additional, Quintana, O., additional, Rodriguez, I., additional, Laraudogoitia, E., additional, Lam, Y.-Y., additional, Henein, M. Y., additional, Mazzone, A., additional, Vianello, A., additional, Perlini, S., additional, Corciu, A. I., additional, Cappelli, S., additional, Cerillo, A., additional, Chiappino, D., additional, Berti, S., additional, Glauber, M., additional, Herrmann, S., additional, Niemann, M., additional, Stoerk, S., additional, Strotmann, J., additional, Voelker, W., additional, Ertl, G., additional, Weidemann, F., additional, Yong, Z. Y., additional, Boerlage - Van Dijk, K., additional, Koch, K. T., additional, Vis, M. M., additional, Bouma, B. J., additional, Henriques, J. P. S., additional, Cocchieri, R., additional, De Mol, B. A. J. M., additional, Piek, J. J., additional, Baan, J., additional, Keenan, N. G. J., additional, Cueff, C., additional, Cimadevilla, C., additional, Brochet, E., additional, Lepage, L., additional, Detaint, D., additional, Iung, B., additional, Vahanian, A., additional, Messika-Zeitoun, D., additional, Otsuka, T., additional, Suzuki, M., additional, Yoshikawa, H., additional, Hashimoto, G., additional, Osaki, T., additional, Tsuchida, T., additional, Matsuyama, M., additional, Yamashita, H., additional, Ozaki, S., additional, Sugi, K., additional, Garcia Alonso, C. J., additional, Vallejo Camazon, N., additional, Ferrer Sistach, E., additional, Camara, M. L., additional, Lopez Ayerbe, J., additional, Bosch Carabante, C., additional, Espriu Simon, M., additional, Gual Capllonch, F., additional, Bayes Genis, A., additional, Deswarte, G., additional, Vanesson, C., additional, Polge, A. S., additional, Huchette, D., additional, Modine, T., additional, Marboeuf, P., additional, Lamblin, N., additional, Bauters, C., additional, Deklunder, G., additional, Le Tourneau, T., additional, Agricola, A., additional, Gullace, M., additional, Stella, S., additional, D'amato, R., additional, Slavich, M., additional, Oppizzi, M., additional, Ancona, M., additional, Margonato, A., additional, Le Ven, F., additional, Etienne, Y., additional, Jobic, Y., additional, Frachon, I., additional, Castellant, P., additional, Fatemi, M., additional, Blanc, J. J., additional, Muratori, M., additional, Montorsi, P., additional, Maffessanti, F., additional, Gripari, P., additional, Teruzzi, G., additional, Ghulam Ali, S., additional, Fusini, L., additional, Celeste, F., additional, Pepi, M., additional, Goebel, B., additional, Haugaa, K., additional, Meyer, K., additional, Otto, S., additional, Lauten, A., additional, Jung, C., additional, Edvardsen, T., additional, Figulla, H. R., additional, Poerner, T. C., additional, Aksoy, H., additional, Okutucu, S., additional, Evranos, B., additional, Aytemir, K., additional, Kaya, E. B., additional, Kabakci, G., additional, Tokgozoglu, L., additional, Ozkutlu, H., additional, Oto, A., additional, Valeur, N., additional, Pedersen, H. H., additional, Videbaek, R., additional, Hassager, C., additional, Svendsen, J. H., additional, Kober, L., additional, Tigen, M. K., additional, Karaahmet, T., additional, Gurel, E., additional, Pala, S., additional, Dundar, C., additional, Basaran, Y., additional, Caldararu, C. I., additional, Ene, E., additional, Dorobantu, M., additional, Vatasescu, R. G., additional, Cikes, M., additional, Bijnens, B., additional, Gasparovic, H., additional, Siric, F., additional, Velagic, V., additional, Lovric, D., additional, Samardzic, J., additional, Ferek-Petric, B., additional, Milicic, D., additional, Biocina, B., additional, Kjaergaard, J., additional, Ghio, S., additional, St John Sutton, M., additional, Moreau, O., additional, Kervio, G., additional, Thebault, C., additional, Leclercq, C., additional, Donal, E., additional, Mornos, C., additional, Rusinaru, D., additional, Petrescu, L., additional, Cozma, D., additional, Ionac, A., additional, Pescariu, S., additional, Dragulescu, S. I., additional, Petrovic, M. Z., additional, Vujisic-Tesic, B., additional, Milasinovic, G., additional, Petrovic, M. T., additional, Nedeljkovic, I., additional, Zamaklar-Trifunovic, D., additional, Calovic, Z., additional, Jelic, V., additional, Boricic, M., additional, Petrovic, I., additional, Kuchynka, P., additional, Palecek, T., additional, Simek, S., additional, Nemecek, E., additional, Horak, J., additional, Hulinska, D., additional, Schramlova, J., additional, Vitkova, I., additional, Aster, V., additional, Linhart, A., additional, Paluszkiewicz, L., additional, Guersoy, D., additional, Ozegowski, S., additional, Spiliopoulos, S., additional, Koerfer, R., additional, Tenderich, G., additional, Gaggl, M., additional, Heinze, G., additional, Sunder-Plassmann, G., additional, Graf, S., additional, Zehetmayer, M., additional, Voigtlaender, T., additional, Mannhalter, C., additional, Paschke, E., additional, Fauler, G., additional, Mundigler, G., additional, Tesic, M., additional, Trifunovic, D., additional, Djordjevic-Dikic, A., additional, Petrovic, O., additional, Petrovic, M., additional, Beleslin, B., additional, Ostojic, M., additional, Draganic, G., additional, Correia, C. 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H., additional, Larsson, M., additional, Kremer, F., additional, Kouznetsova, T., additional, Bjallmark, A., additional, Lind, B., additional, Brodin, L.-A., additional, D'hooge, J., additional, Caputo, M., additional, Antonelli, G., additional, Lisi, M., additional, Giacomin, E., additional, Moustafa, S., additional, Alharthi, M., additional, Deng, Y., additional, Chandrasekaran, K., additional, Mookadam, F., additional, Hayashi, S. Y., additional, Nascimento, M. M., additional, Lindholm, B., additional, Seeberger, A., additional, Nowak, J., additional, Riella, M. C., additional, Brodin, L. 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F., additional, Simpson, J., additional, Ancona, R., additional, Comenale Pinto, S., additional, Caso, P., additional, Severino, S., additional, Nunziata, L., additional, Roselli, T., additional, Dussault, C., additional, Lafitte, S., additional, Habib, G., additional, Reant, P., additional, Derumeaux, G., additional, Thibault, H., additional, Kaladaridis, A., additional, Agrios, I. A., additional, Pamboucas, C. P., additional, Mesogitis, S. M., additional, Vasiladiotis, N. V., additional, Bramos, D. B., additional, Toumanidis, S. T. T., additional, Martiniello, A. R., additional, Santangelo, G., additional, Pedrizzetti, G., additional, Tonti, G., additional, Cioppa, C., additional, Cavallaro, M., additional, Calvi, V., additional, and Chianese, R., additional

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2010
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37. Poster session III * Friday 10 December 2010, 08:30-12:30

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Guldbrand, D., primary, Goetzsche, O., additional, Eika, B., additional, Watanabe, N., additional, Taniguchi, M., additional, Akagi, T., additional, Koide, N., additional, Sano, S., additional, Orbovic, B., additional, Obrenovic-Kircanski, B., additional, Ristic, S., additional, Soskic, L. J., additional, Alhabshan, F., additional, Jijeh, A., additional, Abo Remsh, H., additional, Alkhaldi, A., additional, Najm, H. K., additional, Gasior, Z., additional, Skowerski, M., additional, Kulach, A., additional, Szymanski, L., additional, Sosnowski, M., additional, Wang, M., additional, Siu, C. W., additional, Lee, K., additional, Yue, W. S., additional, Yan, G. H., additional, Lee, S., additional, Lau, C. P., additional, Tse, H. F., additional, O'connor, K., additional, Rosca, M., additional, Magne, J., additional, Romano, G., additional, Moonen, M., additional, Pierard, L. A., additional, Lancellotti, P., additional, Floria, M., additional, De Roy, L., additional, Blommaert, D., additional, Jamart, J., additional, Dormal, F., additional, Lacrosse, M., additional, Arsenescu Georgescu, C., additional, Mizariene, V., additional, Bucyte, S., additional, Bertasiute, A., additional, Pociute, E., additional, Zaliaduonyte-Peksiene, D., additional, Baronaite-Dudoniene, K., additional, Sileikiene, R., additional, Vaskelyte, J., additional, Jurkevicius, R., additional, Dencker, M., additional, Thorsson, O., additional, Karlsson, M. K., additional, Linden, C., additional, Wollmer, P., additional, Andersen, L. B., additional, Catalano, O., additional, Perotti, M. R., additional, Colombo, E., additional, De Giorgi, M., additional, Cattaneo, M., additional, Cobelli, F., additional, Priori, S. G., additional, Ober, C., additional, Iancu Adrian, I. A., additional, Andreea Parv, P. A., additional, Cadis Horatiu, C. H., additional, Ober Mihai, O. M., additional, Chmielecki, M., additional, Fijalkowski, M., additional, Galaska, R., additional, Dubaniewicz, W., additional, Lewicki, L., additional, Targonski, R., additional, Ciecwierz, D., additional, Puchalski, W., additional, Koprowski, A., additional, Rynkiewicz, A., additional, Hristova, K., additional, La Gerche, A., additional, Katova, T. Z., additional, Kostova, V., additional, Simova, Y., additional, Kempny, A., additional, Diller, G. P., additional, Orwat, S., additional, Kaleschke, G., additional, Kerckhoff, G., additional, Schmidt, R., additional, Radke, R. M., additional, Baumgartner, H., additional, Smarz, K., additional, Zaborska, B., additional, Jaxa-Chamiec, T., additional, Maciejewski, P., additional, Budaj, A., additional, Kiotsekoglou, A., additional, Govind, S. C., additional, Gadiyaram, V., additional, Moggridge, J. C., additional, Govindan, M., additional, Gopal, A. S., additional, Ramesh, S. S., additional, Brodin, L. A., additional, Saha, S. 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Published
2010
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45. Ethnic-Specific Normative Reference Values for Echocardiographic LA and LV Size, LV Mass, and Systolic Function The EchoNoRMAL Study

Author

Poppe KK, Doughty RN, Gardin JM, Hobbs FD, McMurray JJ, Nagueh SF, Senior R, Thomas L, Whalley GA, Aune E, Brown A, Badano LP, Cameron V, Chadha DS, Chahal N, Chien KL, Daimon M, Dalen H, Detrano R, Akif Duzenli M, Ezekowitz J, Di Pasquale P, Fukuda S, Gill PS, Grossman E, Kim HK, Kuznetsova T, Leung NK, Linhart A, McDonagh TA, McGrady M, Mill JG, Mogelvang R, Muiesan ML, Ng AC, Ojji D, Otterstad JE, Petrovic DJ, Prendergast B, Rietzschel E, Schirmer H, Schvartzman P, Simova I, Sliwa K, Stewart S, Squire IB, Takeuchi M, Altman DG, Perera R, Triggs CM, Au Yeung H, Beans Picón GA, Anderson T, Dyck J, Ezekowitz JA, Chirinos JA, De Buyzere ML, Gillebert TC, Segers P, Van Daele CM, Walsh HA, de Simone G, Goel K, Misra A, Chen PC, Lin HJ, Su TC, Richards AM, Troughton R, Skov Jensen J, Paterna S, Davies MK, Davis RC, Roalfe A, Calvert M, Freemantle N, Lip GY, Staessen JA, Dargie HJ, Ford I, Galasko G, Lahiri A, Carrington M, Krum H, Zeitz C, Blauwet L, Moelmen Hansen HE, Støylen A, Thorstensen A, Watanabe H, Yoshikawa J, Chambers JC, Kooner J, Davies J, Loke I, Ng L, Leung DY, Arnold L, Coffey S, d'Arcy J, Hammond C, Mabbett C, Lima C, Loudon M, Pinheiro N, Reynolds R, Muraru D, Peluso D, Dal Bianco L, Petrovic J, Fuchs FD, Katova T, Kaku K, Boyd A, Chia EM, Angelo LC, Pereira AC, Krieger JE, Rodrigues SL, Paini A, Agabiti Rosei E, Salvetti M., DE SIMONE, GIOVANNI, IZZO, RAFFAELE, DE LUCA, NICOLA, TRIMARCO, BRUNO, Poppe, Kk, Doughty, Rn, Gardin, Jm, Hobbs, Fd, Mcmurray, Jj, Nagueh, Sf, Senior, R, Thomas, L, Whalley, Ga, Aune, E, Brown, A, Badano, Lp, Cameron, V, Chadha, D, Chahal, N, Chien, Kl, Daimon, M, Dalen, H, Detrano, R, Akif Duzenli, M, Ezekowitz, J, DE SIMONE, Giovanni, Di Pasquale, P, Fukuda, S, Gill, P, Grossman, E, Kim, Hk, Kuznetsova, T, Leung, Nk, Linhart, A, Mcdonagh, Ta, Mcgrady, M, Mill, Jg, Mogelvang, R, Muiesan, Ml, Ng, Ac, Ojji, D, Otterstad, Je, Petrovic, Dj, Prendergast, B, Rietzschel, E, Schirmer, H, Schvartzman, P, Simova, I, Sliwa, K, Stewart, S, Squire, Ib, Takeuchi, M, Altman, Dg, Perera, R, Triggs, Cm, Au Yeung, H, Beans Picón, Ga, Anderson, T, Dyck, J, Ezekowitz, Ja, Chirinos, Ja, De Buyzere, Ml, Gillebert, Tc, Segers, P, Van Daele, Cm, Walsh, Ha, Izzo, Raffaele, DE LUCA, Nicola, Trimarco, Bruno, de Simone, G, Goel, K, Misra, A, Chen, Pc, Lin, Hj, Su, Tc, Richards, Am, Troughton, R, Skov Jensen, J, Paterna, S, Davies, Mk, Davis, Rc, Roalfe, A, Calvert, M, Freemantle, N, Lip, Gy, Staessen, Ja, Dargie, Hj, Ford, I, Galasko, G, Lahiri, A, Carrington, M, Krum, H, Zeitz, C, Blauwet, L, Moelmen Hansen, He, Støylen, A, Thorstensen, A, Watanabe, H, Yoshikawa, J, Chambers, Jc, Kooner, J, Davies, J, Loke, I, Ng, L, Leung, Dy, Arnold, L, Coffey, S, D'Arcy, J, Hammond, C, Mabbett, C, Lima, C, Loudon, M, Pinheiro, N, Reynolds, R, Muraru, D, Peluso, D, Dal Bianco, L, Petrovic, J, Fuchs, Fd, Katova, T, Kaku, K, Boyd, A, Chia, Em, Angelo, Lc, Pereira, Ac, Krieger, Je, Rodrigues, Sl, Paini, A, Agabiti Rosei, E, and Salvetti, M.

Subjects
echocardiography, reference ranges, ethnic appropriate
Abstract

ObjectivesThis study sought to derive age-, sex-, and ethnic-appropriate adult reference values for left atrial (LA) and left ventricular (LV) dimensions and volumes, LV mass, fractional shortening, and ejection fraction (EF) derived from geographically diverse population studies.BackgroundThe current recommended reference values for measurements from echocardiography may not be suitable to the diverse world population to which they are now applied.MethodsPopulation-based datasets of echocardiographic measurements from 22,404 adults without clinical cardiovascular or renal disease, hypertension, or diabetes were combined in an individual person data meta-analysis. Quantile regression was used to derive reference values at the 95th percentile (upper reference value [URV]) and fifth percentile (lower reference value [LRV]) of each measurement against age (treated as linear), separately within sex and ethnic groups.ResultsThe URVs for left ventricular end-diastolic volume (LVEDV), LV end-systolic volume, and LV stroke volume (SV) were highest in Europeans and lowest in South Asians. Important sex and ethnic differences remained after indexation by body surface area or height for these measurements, as well as for the LRV for SV. LVEDV and SV decreased with increasing age for all groups. Importantly, the LRV for EF differed by ethnicity; there was a clear apparent difference between Europeans and Asians. The URVs for LV end-diastolic diameter and LV end-systolic diameter were higher for Europeans than those for East Asian, South Asian, and African people, particularly among men. Similarly, the URVs for LA diameter and volume were highest for Europeans.ConclusionsSex- and/or ethnic-appropriate echocardiographic reference values are indicated for many measurements of LA and LV size, LV mass, and EF. Reference values for LV volumes and mass also differ across the age range.

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