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Gutturals – uvulars, pharyngeals, and laryngeals – are relatively phonetically under-studied, with previous acoustic investigations being limited to a handful of languages (and mainly Arabic). The goal of this paper is twofold: (i) to provide an acoustic documentation of guttural fricatives /χ,ʁ,(ħ,ʕ),h/ in three under-documented languages/dialects – Emirati Arabic, Iraqi Central Kurdish, and Lebanese Western Armenian, and (ii) through this to test the reliability of remote data collection for the analysis of fricatives. Fifty-nine participants residing in United Arab Emirates, Iraq, and Lebanon (18-21 per language) completed an online audio-recording experiment. Word-initial, -medial, and -final fricatives in real words, embedded in carrier phrases, were measured for four spectral moments, relative intensity, and duration. The results showed consistent place and voicing differences in all three languages. Specifically, center of gravity and standard deviation of fricative noise were higher for uvulars and lower for pharyngeals and /h/. Voicing was consistently distinguished by duration, among other variables. Some positional and gender differences were also observed. Overall, the results obtained for fricatives in three languages are remarkably similar to those previously reported for Arabic and other languages, providing evidence for shared acoustic properties of gutturals, as well as confirming the validity of the remote audio recording method.

Folk medicine uses wild herbs, especially from the Lamiaceae family, such as oregano and lavender, in the treatment of many diseases. In the present study, we investigated the antibacterial activity of the essential oils of Origanum glandulosum Desf. and Lavandula dentata L. against multidrug-resistant Klebsiella pneumoniae strains. The chemical composition of essential oils and their effect on the ultrastructure of the tested bacteria and on the release of cellular components that absorb at 260 nm were studied. Furthermore, the cytotoxicity and the production of reactive oxygen species in human lymphocytes treated with essential oils were evaluated. Thymol (33.2%) was the major constituent in O. glandulosum, and β-pinene (17.3%) was the major constituent in L. dentata. We observed ultrastructural damage in bacteria and increased release of cellular material. Furthermore, ROS production in human lymphocytes treated with essential oils was lower than in untreated lymphocytes and no cytotoxicity was observed. Therefore, the essential oils of lavender and oregano could be used as a source of natural antibacterial and antioxidant agents with potential pharmacological applications.

Developments in robotic interventions have greatly affected the field of interventional radiology (IR), particularly when combined with imaging modalities such as fluoroscopy and cone-beam computed tomography (CBCT). The aim of this review is to compare and evaluate the safety, precision, and clinical outcomes of fluoroscopy and CBCT-guided robotic interventions in IR. An extensive search of the literature on PubMed and Google Scholar databases was conducted up to November 2024. Searched terms included "robotic interventions," "fluoroscopy guidance," "cone-beam CT guidance," and "robotic surgery." Literature review showed improved patient outcomes in robotic-assisted procedures, with fewer complications and higher success rates especially in anatomically challenging cases. Fluoroscopy-guided robotic interventions provide real-time imaging, allowing for accurate interventions while CBCT-guided procedures offer enhanced 3D visualization, reducing radiation exposure while maintaining high diagnostic accuracy and shorter needle puncture times. Both fluoroscopy and CBCT-guided robotic interventions play a critical role in advancing interventional radiology and are expected to improve procedural outcomes in IR., Competing Interests: Declaration of competing interest Dr. Ozen is consultant for Boston Sci, Cook Medical, Varian., (Copyright © 2024 Elsevier Inc. All rights reserved.)

Background: Image-guided therapies (IGTs) are commonly used in oncology, but their role in adrenocortical carcinoma (ACC) is not well defined., Materials and Methods: A retrospective review of patients with ACC treated with IGTs. We assessed response to therapy using RECIST v1.1, time to next line of systemic therapy, disease control rate (DCR), local tumor progression-free survival (LTPFS), and complications of IGTs (based on the Common Terminology Criteria for Adverse Events [CTCAE] version 5.0)., Results: Our cohort included 26 patients (median age 56 years [range 38-76]; n = 18 female) who had 51 IGT sessions to treat 86 lesions. IGTs modalities included cryoablation (n = 49), microwave ablation (n = 21), combined microwave and bland trans-arterial embolization (n = 8), bland trans-arterial embolization alone (n = 3), radio-embolization (n = 3), and radiofrequency ablation (n = 2). DCR was 81.4% (70 out of 86), of which 66.3% of tumors showed complete response, 18.6% showed progressive disease, 8.1% showed partial response, and 7.0% showed stable disease. LTPFS rates were 73% and 63% at 1 and 2 years, respectively. Fourteen lesions underwent re-ablation for incomplete response on initial treatment. Sixteen patients (61.5%) received new systemic therapy following IGTs, with a median time to systemic therapy of 12.5 months (95% CI: 8.6 months upper limit not reached). There was 1 reported CTCAE grade 3 adverse event (biloma) following IGT., Conclusions: IGT use in properly selected patients with ACC is safe and associated with prolonged disease control and delay in the need for systemic therapy., (© The Author(s) 2024. Published by Oxford University Press.)

Background: Venous thromboembolism (VTE) is a leading cause of death in patients with cancer. Limited data exist about VTE in patients with adrenocortical carcinoma (ACC). The primary objective of this study was to identify the prevalence of VTE in a cohort of patients with ACC. Secondary objectives were to determine the impact of VTE events on overall survival (OS) and to describe the characteristics of VTE in patients with ACC., Patients and Methods: We retrospectively reviewed data from 289 patients with ACC cared for at a major referral center from February 2010 to June 2022., Results: VTE prevalence was 18.7% (54 events). Thirty patients (55.6%) had pulmonary embolism (PE); 12 patients (22.2%) had deep vein thrombosis (DVT); and 12 patients (22.2%) had both PE and DVT. VTE occurred after ACC diagnosis in 50 patients (92.6%) including 44 patients (88%) with stage 3 or 4 ACC. VTEs were CTCAE grade ≤2 in 32 cases (59.3%), grade 3 in 17 (31.5%), and grade 4 in 2 (3.7%). Thirteen patients (24%) died within 6 months after VTE diagnosis, although there was no statistically significant association between VTE and overall survival., Conclusion: Despite the potential to underestimate the prevalence of VTEs, we found a high frequency of VTE events in patients with ACC. A majority of VTEs occurred in the context of advanced ACC and we observed high short-term mortality. Further studies are needed to validate our findings and investigate mechanisms associated with VTE in ACC., (© The Author(s) 2024. Published by Oxford University Press.)

Objectives: Nargile (waterpipe) smoking has gained popularity in the Middle East and throughout the world. In this research, a new dynamic methodology was conceived. This methodology was deployed for direct in vitro assessment of cytotoxicity, genotoxicity, and apoptotic potential of smoke generated from a single nargile session. Materials and methods: A549 cells were deployed in a designed system to assess the cytotoxicity of generated smoke. The smoke was characterized using Gas chromatography-mass spectrometry (GC-MS) profiling for major organic compounds, whereas the remaining chemical and physical parameters were tabulated from published data. The cytoxicity of smoke generated from five commercial flavored tobacco products was assessed using the (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulphophenyl)-2-H-tetrazolium) (MTS) assay. The genotoxicity was also measured using the comet assay, while apopoptosis was evaluated using Annexin V/propidium iodide staining. Results: The data indicated acute cytotoxicity emanating from smoke products in all tested tobacco flavors. Significant loss of viability and mitochondrial activity was observed 40 min post smoke exposure (Double-Apple flavored), while DNA damage onset was reported as early as 20 min of exposure. Microscopical analysis showed a systematic increase in cell rounding post exposure indicating cellular loss of adhesion and potential membrane damages. Finally, the Annexin V/propidium iodide cellular staining showed signs of late apoptosis or necrosis in exposed cells. Conclusions: The presented data clearly indicated significant in vitro cytotoxicity, genotoxicity and apoptosis/necrosis associated with a 60-min single session of nargile smoking.